CN101631527A

CN101631527A - Topical compositions with suspended particulates

Info

Publication number: CN101631527A
Application number: CN200880008039A
Authority: CN
Inventors: 袁浩明; 桑德拉·朱迪思·圭拉-维加; 威廉·马里奥·伦泽蒂; 雷切尔·孔茨
Original assignee: Reckitt Benckiser LLC
Current assignee: Reckitt Benckiser LLC
Priority date: 2007-03-14
Filing date: 2008-01-25
Publication date: 2010-01-20
Also published as: GB2447478A; AR065780A1; WO2008110740A1; GB2447520A; GB0712987D0; GB0704884D0; ZA200906178B

Abstract

Provided are aqueous foaming topical compositions which provides a topical antimicrobial benefit contain a dispersion of stably suspended cosmetic particulate materials. The antimicrobial benefit is provided by selicylic acid in conjunction with at least one further antimicrobial active compound. The thickener system comprises a polyacrylate crosspolymer and one or more polysaccharide polymers.

Description

Topical composition with suspended particulates

Technical field

The present invention relates to especially be fit to be applied to the foaming topical compositions of human skin.More specifically, compositions of the present invention relates to topical composition, and described topical composition can provide good foaming characteristic, and, except cleaning benefit is provided, can also be in order to the antimicrobial benefit to be provided.

Background technology

This is extensively known in cosmetics, dermatological and field of pharmacology for topical composition.Most of topical compositions are intended to provide after being applied to human skin the particular benefits of at least a (but providing two kinds or two or more usually).For example, personal care composition (the main plan is the conventional Clean-soap of human skin, as washes one's hands with soap or shower soap) is extensively known at cosmetics and personal care product field.When main cleaning benefit was provided, these personal care compositions also provided ancillary benefit usually, as moistening and nourishes rough skin.

Compositions of the present invention aims to provide at least two kinds of major technique benefits, first kind of technical benefits provides effective cleaning, second kind of technical benefits is to reduce the harmful microbe effect, especially reduces the gram-positive microorganism on the local surfaces (for example skin, hair and scalp etc.) and/or the effect of gram-negative micro-organism.Compositions of the present invention can also provide one or more other ancillary technique benefit, for example conditioning skin and/or moistening skin.Utilize existing one or more optional components that are included in preparation of the present invention or the compositions, other optional ancillary benefit can also be provided.Hereinafter will specifically come discussed in more detail with reference to one or more following embodiment that provided.

Summary of the invention

According to an aspect of the present invention, provide be applied to human body especially skin or hair and most preferably being be applied to skin through improved foaming topical compositions, described compositions provides effective cleaning and harmful microbe to reduce simultaneously, especially reduces to be present in lip-deep gram-positive microorganism of the body local of using described topical composition and/or gram-negative micro-organism.

According to a second aspect of the invention, provide as the described foaming topical compositions of first aspect present invention, wherein, described topical composition provides after being applied to human body at least 30 minutes, be preferably at least 45 minutes, more preferably at least 60 minutes harmful microorganism reduces.

According to a further aspect in the invention, provide manufacturing or the production method through improved foaming topical compositions as herein described.

In accordance with a further aspect of the present invention, skin is provided and comprise hair other body surfaces through improved processing method, described method imagined use cleaning effective dose and/or antimicrobial effective dose foaming topical compositions as herein described so that effective cleaning and/or antimicrobial benefit to be provided.

By understanding other features and advantages of the present invention to following detailed description of the present invention and claims.

According to an aspect of the present invention, provide the aqueous foaming topical compositions, described aqueous foaming topical compositions can provide the topical anti-microbial benefit, and comprises:

The anion surfactant component preferably must comprise one or more anion sulfate acid salt surfactants;

Non-essential but preferred cosurfactant component, preferred especially beet alkali surface activator;

Thickener system, it must comprise polyacrylate cross linked polymer thickener component and one or more polysaccharide polymers, described one or more polysaccharide polymers are selected from xanthan gum, guar gum, locust bean gum, Tragacanth or their derivant, particularly guar gum or guar derivative;

Antimicrobial components, at least a other antimicrobially active compounds or material that it must comprise salicylic acid, Salicylate or salicylate and can effectively resist gram negative bacteria and/or gram positive bacteria;

The cosmetics particulate constituent;

One or more selectable components of other component compatibility that optionally can be used for making described topical composition to have the aesthetics of one or more expectations or technical benefits and exist with described compositions;

Wherein, described topical composition has acid pH, is preferably about pH below 5, and in addition, wherein said compositions shows the viscosity at least about 500 centipoises in the time of 20 ℃, preferably shows the viscosity at least about 4000 centipoises in the time of 20 ℃.

Preferably, aqueous foaming topical compositions of the present invention with local surfaces, demonstrate antimicrobial efficacy when for example human body skin, other body surfaces or other similar substrates contact, and after being applied to local surfaces, body surface or other similar substrates at least 30 minutes, be preferably at least 45 minutes, provided harmful microorganism to reduce in more preferably at least 60 minutes.

According to a further aspect in the invention, the method of the Local treatment of human body or its part is provided, and described method has been imagined the step of aqueous foaming topical compositions to provide clean and/or topical anti-microbial to handle to the human body of using described compositions or its part has been provided.

The method of the aqueous foaming topical compositions of the suspension that forms the stable storing that comprises the cosmetics particulate constituent is provided according to another aspect of the invention.

These and other aspects of the present invention provide as described in this manual.

Compositions of the present invention must comprise one or more anion surfactants and/or its salt form.The example of anion surfactant comprises pure sulfuric ester (salt) and sulphonic acid ester (salt); alcohol phosphate ester (salt) and phosphonate ester (salt); alkyl sulfate; alkyl diphenyl base ether sulfonic acid ester (salt); alkyl sulfate (salt); alkyl ether sulphate (salt); the sulfuric ester of alkyl phenoxy poly ethyleneoxy ethanol (salt); alkyl monoglyceride sulfuric ester (salt); alkyl sulfonic ester (salt); alkyl ether sulphate (salt); alpha-olefin sulphonic acid ester (salt); β-alkoxy alkane sulphonic acid ester (salt); alkyl ether sulphonic acid ester (salt); ethoxylated alkyl sulphonic acid ester (salt); alkyl aryl sulfonate (salt); alkyl aryl sulfate (salt); alkyl monoglyceride sulphonic acid ester (salt); alkyl carboxylic acid ester's (salt); alkyl ether carboxylate (salt); alkyl alkoxy carboxylate (salt) with 1～5 mole ethylene oxide; alkyl polyglycol ether sulfuric ester (salt) (contain and be at most 10 moles ethylene oxide); sulfosuccinate (salt); OPEO or NPE phosphate ester (salt); taurine ester (salt); fat amido esilate (salt); fatty acid amide polyoxyethylene sulfuric ester (salt); acylglycerol sulphonic acid ester (salt); fatty oil base glycerol sulfuric ester (salt); alkyl phenol ethylene oxide ether sulfuric ester (salt); alkane sulfuric ester (salt); alkyl phosphate (salt); isethionic acid ester (salt); N-acyl taurate (salt); alkyl Succinamate (salt) and sulfosuccinate (salt); alkyl polysaccharide sulfuric ester (salt); alkyl poly glucoside sulfuric ester (salt); alkyl polyethoxy carboxylate (salt) and sarcosinate (salt) or their mixture.

Other examples of anion surfactant comprise formula (ROSO ₃) _xM or (RSO ₃) _xThe water soluble salt of M or acid, wherein R is preferably C ₆～C ₂₄Alkyl is preferably and has C ₁₀～C ₂₀The alkyl of moieties or hydroxy alkyl, more preferably C ₁₂～C ₁₈Alkyl or hydroxy alkyl, M is H or unit price, bivalence or Tricationic, alkali metal cation (for example sodium ion, potassium ion, lithium ion) for example, perhaps ammonium or have substituent ammonium (for example ammonium methyl cation, Dimethyl Ammonium cation and trimethyl ammonium cation and quaternary ammonium cation, as tetramethyl-ammonium and lupetidine cation with derived from the quaternary ammonium cation of alkylamine such as ethamine, diethylamine, triethylamine and their mixture etc., or the like), and x is an integer, be preferably 1～3, most preferably be 1.With trade mark Hostapur and the commercially available material of Biosoft is the example of these anion surfactants.

More other examples of the anion surfactant that can use in compositions of the present invention comprise alkyl-diphenyl-ether sulfonate and alkyl carboxylate.Other anion surfactants can comprise following salt (for example comprise sodium salt, potassium salt, ammonium salt and have substituent ammonium salt, as monoethanolamine salt, diethanolamine salt and triethanolamine salt): soap, C ₆-C ₂₀Linear alkylbenzene sulfonate (LAS), C ₆-C ₂₂Primary alkyl or secondary alkyl sulfonate, C ₆-C ₂₄Sulfonation polycarboxylic acids, C that the sulfonation of alkene sulfonate, the thermal decomposition product by alkali earth salt prepares ₆-C ₂₄Alkyl polyglycol ether sulfate, alkyl sulfate such as C _14-16Methyl ester sulfate; Acylglycerol sulfonate, fatty oil base glycerol sulfate, alkyl phenol ethylene oxide ether sulfate, alkane sulfonate, alkylphosphonic, isethionate such as acyl-hydroxyethyl sulfonate, N-acyl taurine salt, amber alkyl amide salts and sulfosuccinate, sulfosuccinic acid monoesters (especially saturated and undersaturated C ₁₂-C ₁₈Monoesters), sulfosuccinic acid diesters (especially saturated and undersaturated C ₆-C ₁₄Diester), the sulfate of the sulfate of acyl sarcosinates, alkyl polysaccharide such as alkyl polyglucoside, branched primary alkyl sulphates, alkyl polyethoxy carboxylate are suc as formula RO (CH ₂CH ₂O) _kCH ₂COO ^-M ⁺, wherein R is C ₈-C ₂₂Alkyl, k are 0～10 integers, and M is the solubility salt-forming cation.

Can be simultaneously also can be included as the anionic compound of surfactant and hydrotropic solvent, and or as the part of described anion surfactant component hereinafter or as cosurfactant.Exemplary hydrotropic solvent especially comprises benzene sulfonate, naphthalene sulfonate, C ₁-C ₁₁Alkylbenzenesulfonate, naphthalene sulfonate, C ₅-C ₁₁Alkylsulfonate, C ₆-C ₁₁Alkyl sulfate, alkyl diphenyl ether disulfonate and phosphate ester hydrotropic solvent etc.Water-soluble helping property chemical compound of the present invention provides with the salt form that has suitable counter ion such as one or more alkali metal ion or alkaline-earth metal ions such as sodium or potassium ion, especially sodium ion usually.Yet, other water-soluble cationics such as ammonium ion, single low alkyl group, two low alkyl groups and three low alkyl groups are C _1-4The alkanol ammonium can be used for substituting described alkali metal cation.The exemplary alkyl benzene sulfonate comprises for example cumene sulfonate, xylenesulfonate, toluene fulfonate, cumene sulfonate and their mixture.Exemplary C ₅-C ₁₁Alkylsulfonate comprises hexyl sulfonate, octyl group sulfonate and hexyl/octyl group sulfonate and their mixture.Water-soluble the helping property chemical compound that is particularly useful comprises benzene sulfonate, o-toluene sulfonic acid salt, m-toluene sulfonic acid salt and tosilate; 2,3-xylenesulfonate, 2,4-xylenesulfonate and 4,6-xylenesulfonate; Cumene sulfonate; Wherein these exemplary water soluble additives are generally its salt form, comprise sodium salt and potassium salt form.

It is desirable to, the anion surfactant component of compositions of the present invention must comprise one or more anion sulfate acid salt surfactants, described anion sulfate acid salt surfactant can provide good foaming characteristic in use, and ability flushing after being applied to skin or other local surfaces.By non-limiting way of example, it is alkyl sulfate that the particularly preferred anion surfactant of this function can be provided, especially alkyl ether sulfate, particularly C ₈-C ₁₈Alkyl ether sulfate; Observe according to the inventor, and comprise alpha-alkene sulfonate, especially C at a lot of other anion surfactants commonly used in personal cleaning compositions known in the art ₁₂-C ₁₆Alkene sulfonate such as sodium lauryl sulphate are compared, the more anti-flushing on its local surfaces of using of described alkyl sulfate.These foaming characteristic anion surfactants, especially preferred alkyl ether sulfate reveals high foaming characteristic and the good foam of sending out to compositions table of the present invention.Equally, it is most preferred that, described anion surfactant component comprises one or more alkyl sulfate analog anion surfactants, especially alkyl ether sulfate analog anion surfactants, the particularly described anion surfactant of one or more following embodiment.It is desirable to, the major part of described anion surfactant component is made of one or more alkyl sulfates, especially alkyl ether sulfate, preferred at least 60 weight %, more preferably at least 70 weight %, the described anion surfactant component of further preferred at least 75 weight % comprises alkyl sulfate, particularly alkyl ether sulfate.In some especially preferred embodiment, described anion surfactant component comprises one or more alkyl sulfates of at least 90 weight %, especially one or more alkyl ether sulfates, more preferably described anion surfactant component is substantially by one or more alkyl sulfates, and especially one or more alkyl ether sulfates constitute.

Described anion surfactant component can exist with any effective dose, and with respect to formed the wherein gross weight of the compositions of a part by it, the amount that is preferably with 1 weight %～30 weight % exists.Yet preferably, with respect to formed the wherein gross weight of the foaming topical compositions of a part by it, described anion surfactant ingredients constitute 3 weight %～25 weight % are preferably 10 weight %～20 weight %.By with reference to one or more embodiment, the especially preferred amount of described anion surfactant is disclosed.

Compositions of the present invention can comprise, and preferably comprising one or more really is selected from the cosurfactant of other surfactants of non-ionic surface active agent, amphoteric surfactant and zwitterionic surfactant as described anion surfactant component.Some preferred embodiment in, the cosurfactant component is to exist, and most preferably is beet alkali surface activator.

Exemplary available non-ionic surface active agent is those non-ionic surface active agents that comprise hydrophobicity base portion and hydrophilic chain part, described hydrophobicity base portion such as chain alkyl or alkylated aryl, described hydrophilic chain partly comprise the ethyoxyl of enough numbers and/or propoxyl group part so that described non-ionic surface active agent dissolves at least in part or can be scattered in the water.As limiting examples, these ionic surfactant pack are drawn together polyglycol ether, the polyglycol ether of Sorbitol, ethylene oxide the oxypropylene block copolymer, (C of ethoxylated alkylphenol, ethoxylation and propoxylated fatty alcohol, methyl glucoside ₆-C ₂₄) ethoxylation ester, ethylene oxide and the long-chain amine of fatty acid or the condensation product of amide, and their mixture.Other exemplary ionic surfactant pack are drawn together but are not limited to: methyl gluceth-10, PEG-20 methyl glucose distearate, PEG-20 methyl glucose sesquistearate, C ₁₁-C ₁₅Alkanol polyethers-20, spermol polyethers-8, spermol polyethers-12, dodecylphenol polyethers-12, laureth-15, PEG-20 Oleum Ricini, polysorbate20, stearyl alcohol polyethers-20, polyoxyethylene-10 cetyl ether, polyoxyethylene-10 stearyl ether, polyoxyethylene-20 cetyl ether, polyoxyethylene-10 oleyl ether, polyoxyethylene-20 oleyl ether, ethoxylated nonylphenol, ethoxylation octyl phenol, ethoxylation dodecylphenol or ethoxylized fatty alcohol (C ₆-C ₂₂) (comprising 3～20 ethylene oxide units), polyoxyethylene-20 isocetyl ether, polyoxyethylene-23 glycerol monolaurate, polyoxyethylene-20 glyceryl stearate, the PPG-10 methyl glucose ether, the PPG-20 methyl glucose ether, polyoxyethylene-20 sorbitan monoester, Emulsifier EL-80, polyoxyethylene-15 tridecyl ether, polyoxyethylene-6 tridecyl ether, laureth-2, laureth-3, laureth-4, the PEG-3 Oleum Ricini, PEG 600 dioleates, PEG 400 dioleates and their mixture.Though also can adopt this not concrete open in this area known other non-ionic surface active agents.Described non-ionic surface active agent can be used as the unification compound and exists, and perhaps the mixture with two or more non-ionic surface active chemical compounds exists.

Exemplary available amphoteric surfactant comprises the derivant of the secondary amine and the tertiary amine of the aliphatic group with straight chain or branching, and a substituent group in the wherein said aliphatic substituent group contains 8～18 carbon atoms of having an appointment, at least one described aliphatic substituent group contains the anionic water-soluble group, for example carboxyl, sulfonic group or sulfate.The limiting examples that falls into the chemical compound of this description comprises: 3-(dodecyl amino) sodium propionate, 3-(dodecyl amino) propane-1-sodium sulfonate, 2-(dodecyl amino) sodium ethyl sulfate, 2-(dimethylamino) sodium stearate, 3-(N-carboxyl methyl dodecyl amino) propane-1-disodium sulfonate, octadecyl Disodium iminodiacetate, 1-carboxyl methyl-2-undecyl imidazole sodium and N, N-two (2-ethoxy)-2-sulfato-3-dodecyloxy propylamine sodium.Other exemplary available amphoteric surfactantes comprise sarcosinate, taurine ester, amide sulfosuccinate and betanin, and described betanin comprises the phosphate ester betanin.Specifically do not enumerate but other amphoteric surfactantes of being known in the art though also can adopt at this.

When having the cosurfactant component, wish that it contains one or more betanins.Exemplary available beet alkali surface activator can be represented by following general formula:

Wherein: R ₁Be the alkyl that contains 8～18 carbon atoms, the perhaps acylamino-of representing by following general formula:

Wherein: R is the alkyl with 8～18 carbon atoms, and a is that value is the integer of 1～4 (comprising end value), R ₂Be C ₁～C ₄Alkylene.

The example of preferred betanin has dodecyldimethylammonium hydroxide inner salt, cetyl dimethyl betaine, dodecyl acylamino-propyl-dimethyl betanin, myristyl dimethyl betaine, myristyl acylamino-propyl-dimethyl betanin, dodecyl dimethyl caproic acid ammonium, especially cocoamidopropyl.

Mentioned as mentioned, some preferred embodiment in, the cosurfactant component is to exist, in some especially preferred embodiment, beet alkali surface activator is to exist.When existing, described cosurfactant component can exist with any effective dose, and with respect to formed the wherein gross weight of the described compositions of a part by it, preferably the amount with 0.01 weight %～10 weight % exists.Yet preferably, with respect to formed the wherein gross weight of the topical composition of a part by it, described cosurfactant ingredients constitute 0.1 weight %～8 weight % is preferably 0.5 weight %～5 weight %.

In some preferred implementation, be present in single surfactant in the compositions of the present invention and be the surfactant of getting rid of other kinds and only with one or more anion surfactants of one or more beet alkali surface activators coexistences.

Non-essential but preferably other can to have component be foam booster, it can improve the bubbling character of existing anion surfactant.The preferred foam accelerator-based be in making the compositions thickening, bubble strengthen and one or more alkanolamides of foam stabilization, and is to exist in preferred implementation of the present invention.Provide this foaming to promote the exemplary alkanolamide of function to include but not limited to: coconut oleoyl amine MEA, coconut oleoyl amine DEA, soy amide DEA, lauramide DEA, oleamide MIPA, stearmide MEA, myristamide MEA, lauramide MEA, decyl amide DEA, Oleum Ricini amide DEA, myristamide DEA, stearmide DEA, oleamide DEA, Adeps Bovis seu Bubali amide DEA, lauramide MIPA, Adeps Bovis seu Bubali amide MEA, isostearoyl amine DEA, isostearoyl amine MEA and their mixture.

When existing, with respect to having been formed the wherein gross weight of the topical composition of a part by it, the amount of described one or more alkanolamides is about 10 weight % at the most, but preferred content is about 0.1 weight %～10 weight %.

Compositions of the present invention also must comprise thickener system, described thickener system must comprise polyacrylate cross linked polymer thickening agent and one or more polysaccharide polymers, described polysaccharide polymer for example is xanthan gum, guar gum, locust bean gum, Tragacanth or their derivant, particularly guar gum.

It is desirable to, described polyacrylate cross linked polymer thickening agent shows 10,000～18,000 viscosity, described viscosity obtains by using Brookfield RVT viscometer at 20rpm the gel that is formed by the 2 weight % dispersion liquids of described polyacrylate cross linked polymer thickening agent in 25 ℃ water to be measured.Especially preferred polyacrylate cross linked polymer thickening agent is that according to description, it is C with the commercially available polyacrylate cross linked polymer thickening agent of trade name CARBOPOL AQUA CC (from Noveon) _1-4The cross-linked acrylic acid ester copolymer of alkyl (methyl) acrylate amine functional monomer and hydrophobe.Advantageously, with respect to formed the wherein gross weight of the topical composition of a part by it, described polyacrylate cross linked polymer thickening agent exists with the amount of about 0.1 weight %～about 0.6 weight %.In some preferred implementation, polyacrylate cross linked polymer thickening agent has only CARBOPOL AQUA CC, and does not comprise other polyacrylate-type thickeners.

Thickener component also must comprise one or more polysaccharide polymers that are selected from xanthan gum, guar gum, locust bean gum, Tragacanth or their derivant, particularly guar gum.Advantageously, guar gum is derived from the polysaccharide of Guar beans platymiscium such as hydroxypropyl guar gum, but preferably, described guar gum is the cationic derivative of guar gum, for example with the commercially available melon that hydroxypropyl-trimethyl ammonium chloride of trade name JAGUAR C-162 (from Rhodia).

Though do not wish to be subject to following situation, but the inventor observes, even the combination of preferred polyacrylate cross linked polymer thickening agent and preferred polysaccharide polymer is subsequently at disadvantageous condition of storage, particularly (for example at high temperature, at least 50 ℃, particularly at least 60 ℃) store a week down, be preferably for two weeks, still can provide effect surprising thickening benefit, the excellent suspension of cosmetics particulate constituent also can be provided simultaneously.

Compositions of the present invention can comprise not other thickening agents that can have a negative impact to favourable technical characteristic of the present invention, particularly storage stability characteristic alternatively.These thickening agents can be the annexing ingredients of thickener system of the present invention.

As other optional thickener component, compositions of the present invention can also comprise one or more polysaccharide thickener component such as cellulose, other polycarboxylic acid ester polymers, other polyacrylamides, clay and their mixture such as naturally occurring or modification.

The plain class thickening agent of exemplary fiber is natural existence or based on the thickening agent through modification or treated naturally occurring cellulosic material, for example cellulose, alkylcellulose or cellulose derivative comprise methyl fiber ethyl cellulose, hydroxy methocel, hydroxyethyl-cellulose, hydroxypropyl cellulose, carboxymethyl cellulose, carboxymethyl hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl emthylcellulose, ethyl hydroxy methocel and ethylhydroxyethylcellulose.

It is desirable to, thickener system of the present invention exists with enough amounts, so that the viscosity that compositions of the present invention records in room temperature is at least 500 centipoises.Thickener system should exist with enough amounts, so that adopt Brookfield PV-III type viscometer with No. 63 rotors in 6rpm when room temperature (about 20 ℃) is measured, the final viscosity of compositions according to the order of preferred property rising at least: 500 centipoises, 750 centipoises, 900 centipoises, 1000 centipoises, 1200 centipoises, 1400 centipoises, 1500 centipoises, 1700 centipoises, 1900 centipoises, 2000 centipoises, 2200 centipoises, 2400 centipoises, 2600 centipoises, 2800 centipoises, 3000 centipoises, 3200 centipoises, 3400 centipoises, 3500 centipoises, 3600 centipoises, 3800 centipoises especially preferably are at least about 4000 centipoises.It is desirable to, thickener system of the present invention exists with enough amounts, so that the viscosity that compositions of the present invention records in room temperature is at most 15000 centipoises.Thickener system should exist with enough amounts, so that adopt Brookfield PV-III type viscometer with No. 63 rotors in 6rpm during at indoor temperature measurement, the final viscosity of compositions according to the order of preferred property rising at the most: 15000 centipoises, 14000 centipoises, 13500 centipoises, 13000 centipoises, 12500 centipoises, 12000 centipoises, 11500 centipoises, 11000 centipoises, 10500 centipoises, 10000 centipoises, 9500 centipoises, 9000 centipoises, 8000 centipoises, 8500 centipoises, special preferred viscosities is up to about 7500 centipoises.

For obtaining the required viscosity in the above-mentioned preferable range, though thickener system of the present invention can exist with different amounts, and can exist with any effective dose, but advantageously, with respect to formed the wherein gross weight of the topical composition of a part by it, thickener system exists with the amount of 0.05 weight %～15 weight %.Yet, preferably, order according to the rising of preferred property, with respect to formed the wherein gross weight of the topical composition of a part by it, described thickener system accounts for: 0.1 weight %, 0.5% weight %, 1 weight %, 1.5 weight %, 2 weight %, 2.5 weight % are preferably at least 3 weight % especially.Preferably, order according to the rising of preferred property, with respect to formed the wherein gross weight of the topical composition of a part by it, thickener system of the present invention accounts for 15 weight %, 14 weight %, 13 weight %, 12.5 weight %, 12 weight %, 11 weight %, 10.5 weight %, 10 weight %, 9.5 weight %, 9 weight % at the most, is preferably 8 weight % at the most especially.

In some especially preferred embodiment, remove the polyacrylate cross linked polymer and be selected from xanthan gum, guar gum, locust bean gum, Tragacanth or their derivant, particularly outside one or more polysaccharide polymers of guar gum or guar derivative, compositions does not comprise every other thickening agent.

Compositions of the present invention also must comprise the cosmetics particulate constituent, it is desirable to its dispersion and being suspended in the compositions.The cosmetics microgranule can be to be solid any microparticle material under room temperature (about 20 ℃) temperature and atmospheric pressure, and it can disadvantageous chemical reaction not take place with all the other components of compositions of the present invention.Advantageously, described cosmetics microgranule is insoluble in all the other components of compositions of the present invention, especially make compositions be higher than the temperature of room temperature, particularly at least 50 ℃, the temperature that is preferably at least 60 ℃ kept 24 hours, also like this when being preferably 48 hours at least at least.It is desirable to, described cosmetics particulate constituent demonstrates at least 70 ℃, is preferably at least 100 ℃, more preferably at least 120 ℃, most preferably is at least 130 ℃ fusing point.With respect to formed wherein one or more all the other components of the compositions of the present invention of a part by it, described cosmetics particulate constituent can be an adsorptivity, also can be non-adsorptivity.

Advantageously, the cosmetics particulate constituent can be inorganic or organic, and is laminar or spherical, that is, be pearl or oval-shaped.They can have regular substantially geometry is under the spherical or bar-shaped situation at it for example, also can have irregular geometry for example under its situation for the microparticle material through pulverizing.The exemplary materials that can be used for described cosmetics particulate constituent comprises: the inorganic particles granule that forms by Talcum, Muscovitum, silicon dioxide, Kaolin, boron nitride, such as carbonate, hydroxyapatite, hollow silicon dioxide microsphere, glass microcapsule and ceramic microcapsule, inorganic pigment and their mixture such as deposition calcium carbonate, magnesium carbonate and magnesium bicarbonates.The exemplary materials that can be used for described cosmetics particulate constituent comprises: by such as polyamide polyamide-based powder such as (nylon), polyethylene, polypropylene, polyester, such as acrylic polymers such as polymethyl methacrylates, politef (special teflon) and derived from plant, the crystalline wax of mineral oil or oil or microwax, by such as the formed hollow polymer microsphere of polyvinylidene chloride/acrylonitrile, starch, alginate, the organic fine particles granule that organic dyestuff or pigment and their mixture form.Can use the particulate mixture of two or more cosmetics that the cosmetics particulate constituent is provided.Be preferably providing of cosmetics particulate constituent and peel off the material of benefit.

Preferably, these cosmetics microgranules have about 100 μ m～about 1000 μ m, are preferably about 100 μ m～about 600 μ m, most preferably are the apparent diameter of about 250 μ m～about 600 μ m.Apparent diameter corresponding to basic granules wherein along the diameter of a circle of its minimum dimension (being thickness for thin slice) inscribe.

A preferred class cosmetics microparticle material is based on naturally occurring wax or comprise the synthetic wax of microwax.Exemplary available wax comprises any wax in those the common useful waxes that are used for cosmetics and dermatological.The wax of exemplary natural origin comprises, for example Cera Flava, Brazil wax, candelilla wax, coronule Brazil wax, Japan wax, cork fibrous wax (cork fibre wax) or cerosin, paraffin, montan wax, microwax, lanolin wax, montanin wax, ceresine and such as hydrogenated oil and fats such as hydrogenated jojoba oil.The wax in exemplary synthetic source comprises, for example the polymeric Tissuemat E of derived from ethylene, be 50 ℃ by the synthetic wax that obtains of Fischer-Tropsch, in temperature, when being preferably more than 60 ℃ the ester and the glyceride of solid fatty acid, and silicone wax, being 50 ℃ in temperature for example, is the ester of poly-(two) methylsiloxane of solid alkyl, alkoxyl and/or poly-(two) methylsiloxane when being preferably more than 60 ℃.Can according to conventional methods these waxes be formed microgranule, for example pearl or ball.

Cosmetics particulate constituent of the present invention can provide with any effective dose, but it is desirable to, and exists with the satisfied amount of user that makes compositions aesthetically.The cosmetics particulate constituent is made by indivedual cosmetics microparticle materials, described cosmetics microparticle material can have consistent chemistry or physical composition, and/or have consistent size or size and/or a consistent color, but this is not necessary, and mixture or can be according to different indivedual cosmetics microparticle materials of chemistry and/or physical composition and/or size or size and/or color differentiating as cosmetics particulate constituent of the present invention can be provided.Though cosmetics particulate constituent of the present invention can provide with any effective dose, advantageously, described cosmetics particulate constituent accounts at least 0.01 weight % of topical composition, is preferably at least 0.05 weight %, most preferably is at least 0.1 weight %.Similarly, advantageously, described cosmetics particulate constituent accounts for by it and has formed the wherein 10 weight % at the most of the topical composition of a part, is preferably 5 weight % at the most, and more preferably 2 weight % at the most most preferably are 2 weight % at the most.

In a preferred embodiment, even be present in dispersive cosmetics microgranule in this bulk phase of topical composition subsequently at disadvantageous condition of storage, particularly (for example at high temperature, at least 50 ℃, particularly at least 60 ℃) store a week (being preferably for two weeks) down, still between the storage life, demonstrate surprising good stable.

According to especially preferred embodiment, foaming topical compositions demonstrates the suspension of the excellence of dispersive cosmetics microgranule, make and manually to shake freshly prepd compositions of the present invention tempestuously, then for example by when room temperature (about 20 ℃) is statically placed in it desktop or made it recover resting state other surperficial last 48 hours, most of dispersive cosmetics granules initial range with respect to the bottom of the existing container of compositions of the present invention when returning to resting state after acutely manually shaking can not descend or rise above 5%, being preferably can not descend or rise surpasses 3%, and most preferably being can not descend or rise surpasses 2%." great majority " dispersive cosmetics microgranule is meant at least 90%, is preferably at least 95%, most preferably be at least 97% physically be present in dispersive cosmetics microgranule in the described compositions.Because the cosmetics microgranule of suspended dispersed does not demonstrate perceptible moving in long-time, so this is the especially attractive characteristic feature of the preferred implementation of compositions of the present invention.It is desirable to, after being that room temperature is placed 72 hours with resting state, after more preferably 168 hours, and then after more preferably 10 days, and then when measuring after more preferably 14 days, with respect to its initial range apart from the bottom of the existing container of compositions of the present invention, at least 90%, be preferably at least 95%, the dispersive cosmetics microgranule that most preferably is in this bulk phase that physically is present in compositions of at least 97% surpasses 5% handling can not descend or rise when returning to resting state after shaking, and most preferably being can not descend or rise above 2%.

In some especially preferred embodiment of the present invention, after room temperature kept for 3 weeks with resting state, particularly after 4 weeks, be scattered at least 90% in the topical composition, be preferably at least 95%, most preferably be at least 97% dispersive cosmetics microgranule and can not descend or raise and surpass 5%, be preferably 2%.

In some especially preferred embodiment of the present invention, in 40 ℃, be preferably 50 ℃, and then more preferably 55 ℃, most preferably be at least 60 ℃ kept for 1 week with resting state after, be preferably at least 2 weeks after, be scattered at least 90% in the topical composition, be preferably at least 95%, most preferably be at least 97% dispersive cosmetics microgranule and can not descend or raise and surpass 5%, be preferably 2%.

Compositions of the present invention also must comprise antimicrobial components, it must comprise salicylic acid or its salt form, and at least a other antimicrobially active compounds or material, described antimicrobially active compounds or material are highly resistant to gram negative bacteria and/or gram positive bacteria, and with described compositions in other component compatibility of existing.

Salicylic acid or its salt form of antimicrobial effective dose are provided to compositions of the present invention.Also imagine in compositions of the present invention and except most preferred salicylic acid, also comprise, perhaps replace salicylic acid and comprise salicylate (comprising its monooctyl ester, pentyl ester, phenyl ester, benzene methyl, menthyl ester, glyceride and dipropylene glycol ester), it is believed that salicylate is highly resistant to gram-positive microorganism and/or gram-negative micro-organism equally.

Though having observed other organic acid that are selected from citric acid, lactic acid and glycolic, the inventor when local application, also can provide the antimicrobial benefit, yet because they are more soluble in water than salicylic acid, thereby when local application than salicylic acid or salicylate is easier is washed off or wash out, therefore they only provide instant benefit, and are not specially adapted to provide comparatively persistent antimicrobial benefit.

With respect to formed the wherein gross weight of the compositions of the present invention of a part by it, salicylic acid, Salicylate and/or salicylate are with the amount of about 0.001 weight %～3 weight %, preferably with the amount of 0.01 weight %～2 weight %, but the most desirable less percentage by weight with about 0.05 weight %～0.5 weight % exists.

Except that salicylic acid or its salt form, compositions of the present invention also must comprise other kind of antimicrobially active compounds or material, described antimicrobially active compounds or material are highly resistant to gram negative bacteria and/or gram positive bacteria, and with described compositions in other component compatibility of existing.The exemplary useful chemical compound and the material that can be used as described another antimicrobially active compounds or material comprise one or more antimicrobials, it comprises: pyrithione (particularly Zinc Pyrithione is also referred to as ZPT), dimethyl dihydroxymethyl hydantoin (Glydant

), methylchloroisothiazandnone/Methylisothiazolinone (Kathon CG

), sodium sulfite, sodium sulfite, (Germall 115 for imidazolidinyl urea

), diazonium ureine (Germaill II

), benzyl alcohol, 2-bromo-2-nitropropane-1,3-glycol (Bronopol

), formalin (formaldehyde), butyl carbamic acid iodo propylene ester (Polyphase P 100

), chloroacetamide, Methanamide, methyl dibromo nitrile glutaronitrile (1,2-two bromo-2,4-dicyanobutane or Tektamer

), glutaraldehyde, 5-bromo-5-nitro-1,3-dioxane (Bronidox

), phenethanol, o-phenyl phenol/o-Phenylphenol Sodium salt tetrahydrate, hydroxymethyl Glycine sodium (Suttocide A

), polymethoxy bicyclic oxazolidine (Nuosept C

), (2,6-dimethyl-1,3-diox-4-yl) acetas (dimethoxane), thiomersalate (thimersal), dichlorbenzyl alcohol, captan, adermykon (chlorphenenesin), dichlorophen, methaform, glycerol monolaurate, halogenated diphenyl ether is as 2,4,4 '-three chloro-2 '-hydroxyl-diphenyl ether (Triclosan

Or TCS), 2,2 '-dihydroxy-5,5 '-two bromo-diphenyl ethers, phenolic compound such as phenol, the 2-methylphenol, the 3-methylphenol, the 4-methylphenol, the 4-ethyl-phenol, 2, the 4-xylenol, 2, the 5-xylenol, 3, the 4-xylenol, 2, the 6-xylenol, 4-n-pro-pyl phenol, 4-normal-butyl phenol, 4-n-pentyl phenol, the 4-tert-amyl phenol, 4-n-hexyl phenol, 4-n-heptyl phenol, monoalkyl halogenated phenol and many halogenated alkyls phenol and aromatic series halogenated phenol such as parachlorophenol, the methyl parachlorophenol, the ethyl parachlorophenol, the n-pro-pyl parachlorophenol, the normal-butyl parachlorophenol, the n-pentyl parachlorophenol, the sec-amyl parachlorophenol, the n-hexyl parachlorophenol, the cyclohexyl parachlorophenol, the n-heptyl parachlorophenol, the n-octyl parachlorophenol, o-chlorphenol, the methyl o-chlorphenol, the ethyl o-chlorphenol, the n-pro-pyl o-chlorphenol, the normal-butyl o-chlorphenol, the n-pentyl o-chlorphenol, the tertiary pentyl o-chlorphenol, the n-hexyl o-chlorphenol, the n-heptyl o-chlorphenol, adjacent benzyl parachlorophenol, methyl parachlorophenol between adjacent benzyl, adjacent benzyl-, between-the dimethyl parachlorophenol, adjacent phenylethyl parachlorophenol, methyl parachlorophenol between adjacent phenylethyl, 3-methyl parachlorophenol, 3,5-dimethyl parachlorophenol, 6-ethyl-3-methyl parachlorophenol, 6-n-pro-pyl-3-methyl parachlorophenol, 6-isopropyl-3-methyl parachlorophenol, 2-ethyl-3,5-dimethyl parachlorophenol, 6-sec-butyl-3-methyl parachlorophenol, 2-isopropyl-3,5-dimethyl parachlorophenol, 6-diethylmethyl-3-methyl parachlorophenol, 6-isopropyl-2-ethyl-3-methyl parachlorophenol, 2-sec-amyl-3,5-dimethyl parachlorophenol, 2-diethylmethyl-3,5-dimethyl parachlorophenol, 6-secondary octyl-3-methyl parachlorophenol, parachlorometacresol, p bromophenol, the methyl p bromophenol, the ethyl p bromophenol, the n-pro-pyl p bromophenol, the normal-butyl p bromophenol, the n-pentyl p bromophenol, the sec-amyl p bromophenol, the n-hexyl p bromophenol, the cyclohexyl p bromophenol, adjacent bromophenol, the adjacent bromophenol of tertiary pentyl, the adjacent bromophenol of n-hexyl, n-pro-pyl-, between-the adjacent bromophenol of dimethyl, the 2-phenylphenol, 4-chloro-2-methylphenol, 4-chloro-3-methylphenol, 4-chloro-3, the 5-xylenol, 2,4-two chloro-3, the 5-xylenol, 3,4,5,6-tetrabromobisphenol-methylphenol, 5-methyl-2-amyl phenol, 4-isopropyl-3-methylphenol, parachlorometaxylenol, dichloro meta xylenol(DCMX, chlorothymol, 5-chloro-2-hydroxy diphenyl methane, resorcinol and derivant thereof comprise methylresorcinol, ethyl resorcinol, the n-pro-pyl resorcinol, n-butyl resorcinol, the n-pentyl resorcinol, the n-hexyl resorcinol, the n-heptyl resorcinol, the n-octyl resorcinol, the n-nonyl resorcinol, the phenyl resorcinol, the benzyl resorcinol, the phenethyl resorcinol, the phenyl propyl resorcinol, to the chlorophenylmethyl resorcinol, 5-chloro-2,4 dihydroxy diphenyl methanes, 4 '-chloro-2,4-dihydroxy diphenyl methane, 5-bromo-2,4-dihydroxy diphenyl methane and 4 '-bromo-2,4-dihydroxy diphenyl methane, bisphenol compound is as 2,2 '-methylene two (4-chlorophenol), 2,2 '-methylene two (3,4, the 6-trichlorophenol, 2,4,6,-T), 2,2 '-methylene two (4-chloro-6-bromophenol), two (2-hydroxyls-3, the 5-Dichlorobenzene base) sulfide and two (2-hydroxyl-5-chlorophenylmethyl) sulfide, benzoate (nipalgin) is as methyl hydroxybenzoate, propylparaben, butoben, ethyl hydroxybenzoate, the nipalgin isopropyl ester, the nipalgin isobutyl ester, the nipalgin benzene methyl, methyl nipalgin sodium and propyl group nipalgin sodium, halogenation carbanilide (for example 3,4,4 '-trichlorine carbanilide (Triclocarban

Or TCC), 3-trifluoromethyl-4,4 '-dichloro carbanilide, 3,3 ', 4-trichlorine carbanilide and 2,4-two chloro-3,5-meta-xylene phenol (" DCMX ").Preferred described phenol non-cationic antimicrobial wherein especially preferably is used in parachlorometacresol (" PCMC "), particularly parachlorometaxylenol (" PCMX ") in the compositions of the present invention.

With respect to formed the wherein gross weight of the compositions of the present invention of a part by it, described one or more other antimicrobially active compounds or material exist with the amount of about 0.001 weight %～3 weight %, preferably the amount with 0.1 weight %～2 weight % exists, but the most desirable amount with about 0.1 weight %～0.5 weight % exists.

The inventor also finds, excellent antimicrobial efficacy can be provided in the time of in foaming topical compositions of the present invention also remains on specific acid pH scope, described pH is preferably about below 6, be preferably about 2～5.5, order according to the rising of preferred property, described pH more preferably at least 2.2,2.4,2.5,2.6,2.8,3,3.2,3.4,3.5,3.6,3.8,4,4.1 and 4.2, meanwhile with the order of preferred property rising, described pH is at the most 5.5,5.4,5.2,5,4.8,4.7,4.6,4.5,4.4 and 4.3.

Do not wish to be confined to following supposition, it is believed that and select salicylic acid, Salicylate and/or salicylate and one or more other antimicrobially active compounds or material, can when being locally applied to human body skin, provide harmful microbe is killed fast, and more persistent antimicrobial benefit may also can be provided.This antimicrobial benefit is very beneficial for the control body odour, and the pure and fresh common sensation after the use compositions of the present invention is provided.

Topical composition of the present invention can comprise and can be used for making described topical composition to have one or more other the selectable components of one or more desired aesthetics or technical benefits.In some of the preferred embodiment of the invention,, can consider one or more selectable components described below as necessary component according to particularly preferred embodiment.These selectable components are included in additive common in cosmetics, pharmacy or the dermatological field and adjuvant, as hydrophilic or lipotropy gellant, hydrophilic or lipotropy activating agent, wetting agent, opacifiers, antiseptic, antioxidant, solvent (especially organic solvent), pH regulator agent, pH buffer agent, chelating agen, aromatic, the spice that fragrant benefit can be provided or other materials, filler, antiseptic, dyestuff or coloring agent and light stabilizer (comprising UV (ultraviolet) absorbent).The consumption of various described additives and adjuvant is its conventional amount used in described field, for example accounts for 0.01%～10% of described composition total weight.

A kind of selectable components that can be included in the compositions of the present invention is a latex.Described latex is used to compositions that the emulsifying effect is provided.They are such materials: be generally the non-soluble polymer in the carrier or emulsion, dispersion liquid or the suspension of copolymer.Described carrier can be aqueous solvent, aqueous solvent/ORGANIC SOLVENT MIXTURES or organic solvent.Described latex can be based on homopolymer or copolymer.It is envisaged that described copolymer contains two or more different monomers, described two or more different monomers connect with block arrangement or random arrangement.

The exemplary copolymers that is applicable to described latex emulsion comprises the copolymer that is formed by following material: the C of styrene, α-Jia Jibenyixi, divinylbenzene, acrylic acid, methacrylic acid, acrylic or methacrylic acid ₁～C ₂₀Ester, acrylamide, Methacrylamide, maleic acid, vinyl acetate .beta.-methylacrylic acid, vinyl neodecanoate and butenoic acid.The example of carboxylate type copolymer is polyacrylate and the poly-methyl acrylate and the free acid form of styrene/acrylic Arrcostab and partial esterification.Wherein, previous materials is poly-(butyl methacrylate), poly-(acrylic acid methyl ester .), poly-(methyl methacrylate), poly-(acrylic acid/acrylic acid C ₁～C ₂₀Arrcostab) and poly-(methacrylic acid/methacrylic acid C ₁～C ₂₀Arrcostab).These copolymers can prepare corresponding monomer polymerization by the oil-in-water or the water-in-oil emulsion polymerization technique of routine.Alternatively, pseudo-latex can be by with prefabricated polymer and/C ₁～C ₂₀The alkanol esterification prepares.The average diameter of dispersive polymer can be about 0.001 micron～about 120 microns, be preferably about 0.01 micron～about 1 micron, most preferably be about 0.1 micron～about 0.5 micron.

The number-average molecular weight of polymer of the present invention can for about 1,000～about 1,000,000, be preferably about 2,000～about 500,000, most preferably be about 5,000～about 20,000.

Can use various technology known in the art to prepare the particulate latex of non-soluble polymer.These technology especially comprise in batches, semicontinuous and inoculation emulsion polymerization technology etc.

Available particularly preferred latex in the present invention be at present with trade mark ACUSOL (from Rohm﹠amp; Haas Inc.) commercially available latex.Described latex be characterised in that pH be about 2～about 3, have in water about 0.1 micron～about 0.5 micron of about 40% solid and a particle diameter.Concrete ACUSOL polymer comprises the ACUSOLOP301 that is described to the phenylethylene ethylene/propenoic acid ester polymer latex, be described to the ACUSOLOP302 of phenylethylene ethylene/propenoic acid ester/divinyl benzene copolymer latex, be described to the ACUSOL OP303 of styrene/acrylamide copolymer latex, be described to the ACUSOLOP305 of the latex of styrene/PEG-10 maleate/Nonyl pheno (10) ether maleate/acrylate copolymer and phenylethylene ethylene/propenoic acid ester/PEG-10 dimaleate copolymer.Other in the present invention available preferred latexes comprise those styrene/polyvinyl pyrrolidone copolymer and styrene/acrylic emulsion.These preferred latexes comprise operable styrene/polyvinyl pyrrolidone copolymer, for example comprise that POLECTRON 430 is (from ISPTechnologies, Inc.) and phenylethylene ethylene/propenoic acid ester/divinyl benzene copolymer sodium salt and Nonyl pheno (4) ether ammonium sulfate; Styrene/PEG-10 maleate/Nonyl pheno (10) ether maleate/acrylate copolymer sodium salt and Nonyl pheno (4) ether ammonium sulfate; Styrene/acrylamide copolymer and Nonyl pheno (4) ether ammonium sulfate; Phenylethylene ethylene/propenoic acid ester copolymer and sodium lauryl sulphate and octyl phenol polyoxy ethylene (9) ether; Phenylethylene ethylene/propenoic acid ester copolymer sodium salt and sodium lauryl sulphate and tridecyl polyoxyethylene (7) ether; Methacrylate/styrol copolymer sodium salt and sodium lauryl sulphate and tridecyl polyoxyethylene (7) ether and dodecyl diphenyl oxidation thing-sodium disulfonate; With the phenylethylene ethylene/propenoic acid ester copolymer sodium salt (from CSA, Inc., Greenville, S.C.).

According to some preferred embodiment, when described latex is present in the compositions, with respect to formed the wherein gross weight of the described topical composition of a part by it, described latex can exist with the amount of about 5 weight % at the most, preferably the amount with about 0.001 weight %～about 3 weight % exists, preferably the amount with about 0.1 weight %～about 1.2 weight % exists, and the amount that most preferably is with about 0.1 weight %～about 1 weight % exists.Simultaneously, the amount of the non-soluble polymer that exists in described latex can be preferably about 0.1 weight %～about 60 weight % for about 0.01 weight %～about 90 weight % of described latex, and optimum is about 10 weight %～about 50 weight %.

Topical composition also can be a cation polyquaternary ammonium salt type polymer.This is extensively known in the topical composition field for this material.Can use this type of cationic polymer of various grades, especially: polyquaternary ammonium salt 1; Polyquaternary ammonium salt 2; The copolymer of hydroxy ethyl cellulose and diallyldimethylammonium chloride (commercially available) as polyquaternary ammonium salt 4; The homopolymer of diallyldimethylammonium chloride (commercially available) as polyquaternary ammonium salt 5; Dimethyl diallyl ammonium chloride homopolymer (commercially available) as polyquaternary ammonium salt 6; The copolymer of diallyldimethylammonium chloride and acrylamide (commercially available) as polyquaternary ammonium salt 7; Methyl and stearyl (steardyl) dimethyl amino ethyl methacrylate is through the quaternised polyquaternary ammonium salt of dimethyl disulfide acid esters (commercially available as polyquaternary ammonium salt 8); Poly dimethyl amino-ethyl methacrylate is through the quaternised polyquaternary ammonium salt of bromomethane (commercially available as polyquaternary ammonium salt 9); The polyquaternary ammonium salt (commercially available) that the epoxide reaction that is replaced by hydroxy ethyl cellulose and trimethyl ammonium forms as polyquaternary ammonium salt 10; React the polyquaternary amine polymer (commercially available) that forms by ethenyl pyrrolidone and dimethyl amino ethyl methacrylate as polyquaternary ammonium salt 11; React the polyquaternary ammonium salt (commercially available) that makes by ethyl methacrylate/methylpropenoic acid rosin ester/methacrylic acid diethylamino ethyl ester copolymer and dimethyl disulfide acid esters as polyquaternary ammonium salt 12; The polyammonium salt (commercially available) that makes by the reaction of ethyl methacrylate/methacrylic acid grease/methacrylic acid diethylamino ethyl ester copolymer and dimethyl disulfide acid esters as polyquaternary ammonium salt 12; The polyquaternary ammonium salt (commercially available) that makes by the reaction of ethyl methacrylate/methacrylic acid grease/methacrylic acid diethylamino ethyl ester copolymer and dimethyl disulfide acid esters as polyquaternary ammonium salt 13; Polyquaternary ammonium salt 14; The copolymer of Methacrylamide and Beta-methyl acryloxy ethyl-trimethyl salmiac (commercially available) as polyquaternary ammonium salt 15; The polyquaternary ammonium salt (commercially available) that forms by methyl chloride vinyl imidazole salt and vinyl pyrrolidone as polyquaternary ammonium salt 16; The polyquaternary ammonium salt (commercially available) that makes by the reaction of adipic acid and dimethylaminopropyl amine and Dichloroethyl ether as polyquaternary ammonium salt 17; The polyquaternary ammonium salt that the reaction of union diacid and dimethylaminopropyl amine and Dichloroethyl ether makes (commercially available) as polyquaternary ammonium salt 18; By polyvinyl alcohol and 2, the polyquaternary ammonium salt (commercially available) that the 3-epoxy-the propylamine reaction makes as polyquaternary ammonium salt 19; By polyethylene octadecyl ether and 2, the polyquaternary ammonium salt (commercially available) that the reaction of 3-epoxy propylamine makes as polyquaternary ammonium salt 20; The copolymer of acrylic acid and dimethyl diallyl ammonium chloride (commercially available) as polyquaternary ammonium salt 22; The polyquaternary ammonium salt (commercially available) that the epoxide reaction that is replaced by hydroxy ethyl cellulose and lauryl dimethyl ammonium makes as polyquaternary ammonium salt 24; React the block copolymer (commercially available) that forms by polyquaternary ammonium salt 2 and polyquaternary ammonium salt 17 as polyquaternary ammonium salt 27; The polyquaternary ammonium salt (commercially available) that constitutes by vinyl pyrrolidone and dimethylaminopropyl methyl acrylamide monomer as polyquaternary ammonium salt 28; With propylene oxide reaction and by the quaternised chitosan of chloropropylene oxide (commercially available) as polyquaternary ammonium salt 29; Polyquaternary ammonium salt 30; The polyquaternary ammonium salt (commercially available) that the reaction of DMAPA acrylate/acrylic acid/propylene nitrogen (acrylonitrogen) copolymer and diethyl sulfide acid esters makes as polyquaternary ammonium salt 31; Polyquaternary ammonium salt 32; Polyquaternary ammonium salt 33; Polyquaternary ammonium salt 34; Polyquaternary ammonium salt 35; Polyquaternary ammonium salt 36; Polyquaternary ammonium salt 37; The polyquaternary ammonium salt of the terpolymer of acrylic acid/diallyldimethylammonium chloride/acrylamide (commercially available) as polyquaternary ammonium salt 39; Polyquaternary ammonium salt 42; The polymer (commercially available) of the copolymer of acrylamide, acrylamido oxypropyl trimethyl ammonium chloride, 2-acylamino-propyl group acrylamide sulphonic acid ester and DMAPA as polyquaternary ammonium salt 43; The polyquaternary ammonium salt (commercially available) that constitutes by vinyl pyrrolidone and quaternized imidazoline monomer as polyquaternary ammonium salt 44; Polyquaternary ammonium salt 45; The polyquaternary ammonium salt (commercially available) that makes by caprolactam and vinyl pyrrolidone and the reaction of methyl ethylene imidazoles as polyquaternary ammonium salt 46; The polychlorostyrene quaternary ammonium salt (commercially available) that forms by acrylic acid and methacrylamidopropyltrimethyl trimethyl ammonium chloride and methacrylic acid polyisocyanate polyaddition as polyquaternary ammonium salt 47; The copolymer (commercially available) of methacryl ethyl betanin, methacrylic acid 2-hydroxyethyl ester and methacryl ethyl-trimethyl salmiac as polyquaternary ammonium salt 48; The copolymer of methacryl ethyl betanin, PEG-9 methacrylate and methacryl ethyl-trimethyl salmiac (commercially available) as polyquaternary ammonium salt 49; Polyquaternary ammonium salt 50; Polyquaternary ammonium salt 51; Polyquaternary ammonium salt 52; The copolymer of acrylic acid, acrylamide and methacrylamidopropyltrimethyl trimethyl ammonium chloride (commercially available) as polyquaternary ammonium salt 53; The polyquaternary ammonium salt (commercially available) that makes by the reaction of aspartic acid and C6～C18 alkylamine and dimethylamino propylamine and sodium chloroacetate as polyquaternary ammonium salt 54; React the polychlorostyrene quaternary ammonium (commercially available) that forms as polyquaternary ammonium salt 55 by vinyl pyrrolidone, dimethylaminopropyl Methacrylamide and methacrylamido propyl group lauryl dimethyl ammonium chloride; And the polyquaternary ammonium salt (commercially available) that constitutes by isophorone diisocyanate, butanediol and dihydroxy ethyl dimethyl methyl ammonium sulfate monomer as polyquaternary ammonium salt 56.Above-mentioned each cationic polymer especially at InternationalCosmetic Ingredient Dictionary and Handbook, all has description in the 2nd volume (the 9th edition, 2002) the 1311st page～the 1319th page at document.Though other polyquaternary ammonium salt chemical compounds are not specifically enumerated at this, can be used in the compositions of the present invention yet.Especially preferred is polyquaternary ammonium salt 7.

When existing, with respect to formed the wherein gross weight of the topical composition of a part by it, advantageously described one or more cation polyquaternary ammonium salt type polymer exist with the amount of about 0.001 weight %～2.5 weight %, preferably the amount with 0.01 weight %～2 weight % exists, but it would be desirable that the less percentage by weight with about 0.05 weight %～1 weight % exists.

Described topical composition can comprise one or more antiseptic.Exemplary available antiseptic comprises the compositions that comprises following substances: nipalgin (comprising methyl hydroxybenzoate and ethyl hydroxybenzoate), glutaraldehyde, formaldehyde, 2-bromo-2-nitropropane-1,3-glycol, 5-chloro-2-methyl-4-isothiazoline-3-ketone, 2-methyl-4-isothiazoline-3-ketone and their mixture.An exemplary compositions is the combination of 5-chloro-2-methyl-4-isothiazoline-3-ketone and 2-methyl-4-isothiazoline-3-ketone, wherein, with respect to the total amount of described antiseptic, arbitrary component can be present in the mixture with any amount between 0.001 weight %～99.99 weight %.Reason for availability, most preferred antiseptic is the antiseptic of selling as antiseptic composition with trade name KATHON CG/ICP (from Rohmand Haas Inc.), and it comprises the mixture of 5-chloro-2-methyl-4-isothiazoline-3-ketone and 2-methyl-4-isothiazoline-3-ketone.Other available antiseptic compositions comprise KATHON CG/ICP II (from Rohm and Haas Inc.), PROXEL (from Zeneca), SUTTOCIDE A (from SuttonLaboratories) and TEXTAMER 38AD (from Calgon Corp.).When existing, the content of described antiseptic is for through finding especially effectively to delay or suppress any amount that harmful microorganism is grown in described topical composition in room temperature preservation reaches the process of several months.In the time of in being present in compositions, according to some preferred embodiment, with respect to formed the wherein gross weight of the described topical composition of a part by it, described antiseptic composition advantageously exists with the amount of about 1.5 weight % at the most, preferably the amount with about 0.00001 weight %～about 0.5 weight % exists, and the amount that most preferably is with about 0.0001 weight %～0.1 weight % exists.

Described topical composition can comprise the filler of one or more powder types.As limiting examples, these powder comprise the Magnesiumaluminumsilicate of Chalk, Talcum, Kaolin, starch, smectite clay, chemical modification, organically-modified montmorillonitic clay, aluminium hydrosilicate, aerosil, starch ocentyl succinic aluminum and their mixture.In the time of in being present in compositions, according to some preferred implementation, with respect to having been formed the wherein gross weight of the described topical composition of a part by it, one or more filleies can exist with the amount of about 5 weight % at the most, and preferably the amount with about 0.001 weight %～about 5 weight % exists.

Described topical composition can comprise fragrance components, this fragrance components can be based on natural aromatic agent and synthetic aromatising agent, and modal is the mixture or the blend of multiple described aromatic, share with carrier such as organic solvent or ORGANIC SOLVENT MIXTURES alternatively, described aromatic is dissolved in, is suspended in or is scattered in the described carrier.Mode by limiting examples, the natural aromatic agent comprises flower (Bulbus Lilii, lavandula angustifolia, Flos Rosae Rugosae, jasmine, orange blossom, the fragrant cananga), stem and leaf (Flos Pelargonii, Herba Pogostemonis, Citrus), fruit (Pimpinella anisum Linn., coriander, caraway, Juniperus oxycedrus), peel (bergamot, Fructus Citri Limoniae, orange), root (Semen Myristicae, Radix Angelicae Sinensis, Herba Apii graveolentis, Elettaria cardamomum (L.) Maton, Costus speciosus, Rhizoma Iridis Tectori, Rhizoma Acori Graminei), timber (Masson Pine, sandalwood, lignum-vitae, Cupressus funebris Endl., rosewood), medicinal herbs and grass (tarragon, lemon grass (Cymbopogon citratus), Salvia japonica Thunb., Herba thymi vulgaris), needle and branch (PiceameyeriRehd. Et Wils., fir, pinaster, short living pinaster), resin and face cream (galbanum, elemi, Benzoinum, Myrrha, Olibanum, Stigma Croci) extract, and other other extracts, as acetaminol and menthol.It can advantageously contain menthol, because can also provide feel cool when local application.Also can use animal material, for example civet and castoreum.Typical synthetic perfume chemical compound is the product of ester, ether, aldehyde, ketone, pure and mild hydro carbons.The ester perfume examples for compounds has phenylmethyl acetate, phenoxyethyl isobutanoate, to tert-butylcyclohexyl acetas, linalyl acetate, the former ester of acetic acid dimethyl benzene methyl, phenylethyl acetas, linalyl benzoate, Formic acid benzylester, ethyl methyl phenyl glycinate, 2-Propenyl 3-cyclohexylpropanoate, styralyl propionate and salicylic acid benzene methyl.Ether comprises for example benzyl ethylether, and aldehyde comprises straight chain alkanal, citral, citronellal, citronellyl oxygen acetaldehyde, cyclamen aldehyde, hydroxycitronellal, lilestralis and the clean red aldehyde of ripple that for example contains 8～18 carbon atoms.The example of suitable ketone has ionoionone, α-Yi Jiajiziluolantong and vertofix coeur.The alcohol that is fit to has anethole, citronellol, acetaminol, isoeugenol, geraniol, linalool, the pure and mild terpinol of phenethyl.Described hydro carbons mainly comprises terpenes and face cream.Yet the mixture that preferably uses different flavor compounds is with the satisfied fragrance of common formation.Other suitable spice quintessence oils are the relatively low volatile quintessence oils that have that are used as aromatised fraction usually.Example has sage oil, chamomile oil, Oleum Caryophylli, melissa oil, Oleum menthae, Cortex Cinnamomi leaf oil, limette caul-fat, oleum juniperi e baccarae, vetiver oil, Olibanum oil, galbanum oil, labolanum oil and lavandin oil.Other useful Available Materials have farnesol (being 3,7,11-trimethyl 12-2,6, the chemical popular name of 10-three enols) in described fragrance components, and it can obtain from several commercial source, and can be used in the cosmetic composition, mainly as fragrance components.Though do not wish to be subject to hereinafter, guess the antimicrobial efficacy when containing farnesol can improve described compositions in local application with its normal mode use.When using described compositions, these can advantageously reduce the malodorous existence due to the microorganism of existence, and therefore improve the sensation of health " pure and fresh ".

In the time of in being present in compositions, according to some preferred embodiment, described fragrance components can be existed by any effective dose of the user identification of described topical composition making it, yet, advantageously with respect to formed the wherein gross weight of the described compositions of a part by it, exist with the amount of about 0.5 weight % at the most, preferably the amount with about 0.00001 weight %～about 0.3 weight % exists, and most preferably the amount with about 0.0001 weight %～0.25 weight % exists.

Compositions of the present invention can comprise one or more coloring agent, for example known in the art can be used for cosmetics or topical composition, can be used for making compositions of the present invention to have the dyestuff or the pigment of desirable color or tone.Can adopt with any coloring agent of other component compatibility that form described topical composition, and can exist with any amount that can effectively obtain desirable visual effect.Exemplary colorants comprises pigment, especially inorganic red pigment such as ferrum oxide, hydrated ferric oxide. and iron titanate; Inorganic brown such as gamma-iron oxide; Inorganic yellow pigment such as iron oxide yellow and loess; Inorganic black pigment such as iron oxide black and white carbon black; Inorganic violet pigment such as manganese violet and cobalt violet; Inorganic viridine green such as chromic oxide gel, chromium oxide, cobalt oxide and cobalt titanate; Inorganic blue pigment such as Prussian blue and ultramarine blue; The tar pigment color forms sediment; The natural dye color forms sediment; And the synthetic resin powder complex of the above inorganic pigment etc.Advantageously, with respect to be made of the wherein gross weight of the described compositions of a part coloring agent, one or more coloring agent can exist with the amount of about 0.001 weight %～about 0.1 weight %.

Described topical composition can comprise one or more wetting agents, comprise polyhydroxy-alcohol, described polyhydroxy-alcohol comprises ployalkylene glycol and the many alcohol of alkylene and derivant thereof or the like, comprising propylene glycol, dipropylene glycol, polypropylene glycol, Polyethylene Glycol and derivant thereof, Sorbitol, hydroxypropyl Sorbitol, erythritol, threitol, tetramethylolmethane, xylitol, glucitol, mannitol, hexanediol, butanediol (for example 1, the 3-butanediol), hexanetriol (for example 1,2,6-hexanetriol), glycerol, ethoxylated glycerol and propoxylated glycerol.Other available wetting agents comprise 2-Pyrrolidone-5-carboxylic acid sodium, guanidine; Glycolic and glycollate (for example alcohol acid phosphate and glycolic season alkylammonium); Lactic acid and lactate (for example DL-Lactic acid ammonium salt. and lactic acid season alkylammonium); With its various forms of Aloes (aloe vera) (for example Aloe gel); Hyaluronic acid and its derivant (for example salt derivative, as hyaluronate sodium); The lactamide monoethanolamine; The acetamide monoethanolamine; Urea; And panthenol.Described wetting agent can use separately or can comprise two or more wetting agents in topical composition of the present invention.In described wetting agent, because Aloe is the product of natural origin, the Aloe of therefore preferred one or more forms.When having wetting agent, according to some preferred embodiment, one or more wetting agents that can contain effective dose, with respect to formed the wherein gross weight of the described compositions of a part by wetting agent, described wetting agent can advantageously be 0.01 weight %～2.5 weight %, is preferably 0.01 weight %～2 weight %.

Foaming topical compositions of the present invention can comprise one or more components, especially can comprise one or more quintessence oils, and it is through selecting so that so-called " aromatotherapy benefit " to be provided to user.Quintessence oil is the compound mixture of different organic molecules such as terpenes, alcohol, ester, aldehyde, ketone and phenol.These quintessence oils extract flower, stem, leaf, root and the skin from natural plant such as armaticity plant usually.Though quintessence oil can use separately, the blend that also often adopts quintessence oil is to provide fragrant benefit of associating and possible treatment benefit.

Provide the various quintessence oils of aromatotherapy benefit to join in the topical composition of the present invention with single quintessence oil or as the mixture of two or more quintessence oils.Also should recognize when using, provide the quintessence oil of aromatotherapy benefit to comprise fragrance components discussed above by all or part of alternative other fragrance components arbitrarily, this is because many quintessence oil abnormal smells from the patients strong and fragrant (odiferous) that the aromatotherapy benefit is provided.Provide these quintessence oils of aromatotherapy benefit to use separately, use or be used in combination with other fragrance components as the blend of quintessence oil or mixture, described other fragrance components can be synthetic make or natural origins, but not necessarily derived from or contain quintessence oil itself.Usually, because its effectiveness, quintessence oil being dispersed in liquid-carrier such as one or more organic solvents usually provides, and described quintessence oil dissolves in described liquid-carrier or disperses.

As limiting examples, can be used on provides the exemplary available quintessence oil of aromatotherapy benefit to comprise in the topical composition of the present invention: oleum abietis, Amyris balsamifera bark oil (AmyrisBalsamifera oil), Oleum Anisi Stellati, savory oil (Balm Mint oil), basil oil, laurel oil, monarda oil, oleum bergamottae, birch oil, bitter orange oil, cabbage rose oil (Cabbage Rose oil), calendula oil, California Semen Myristicae oil, Camellia oil, bird SHUJIAO resin (Capsicum Frutescersoleoresin), caraway oil, Cardamom oil, Cedar oil, Japanese cypress oil, Chamomile oil, Oleum Cinnamomi, citronella oil, Salvia Sclare L.oil, Oleum Caryophylli, Folium Caryophylli oil, Fructus Coriandri oil, coriander seed oil, cyperus esculentus oil, pitch, eucalyptus citriodora oil, Eucalyptus Globulus oil, fennel oil, the Florida gardenia flower oil, Herba Erodii oil, oil of ginger, oil of grapefruit, hop oil, Herba Hyperici perforati oil, Caulis et Folium Hyptidis suaveolentis oil, purple Chinese scholartree oil (Indigo Bushoil), Jasmin oil, Juniperus communis L. oil (Juniperus Communis Oil), Cedrus deoclar (Roxb.) G. Don oil, labdanum oil, laurel fat, lavandin oil, Oleum lavandula angustifolia, Fructus Citri Limoniae oil, Indian oil of verbena, Leptospermum scoparium oil, white lemon oil, basswood oil, litsea cubeba oil, lovage oil, tangerine oil, the Cinnamomum japonica haze wax, Matricariae aetheroleum, Morocco's chamomile oil, muskrat oil, Myrrha, myrtol, Norway spruce oil, Semen Myristicae oil, potted flower muirapauma oil (Olax Dissitiflora Oil), Olibanum oil, opopanax oil, orange blossom oil, orange oil, palmarosa oil, parsley seed oil, passionflower oil, patchouli oil, Flos Pelargonii oil, Fructus Piperis peppermint oil, Oleum Pini, pine tar, pine nut oil, Oleum Pini, pinaster seed oil, oil of rosemary, Oleum Rosae Rugosae, rosewood oil, Rue oil., sage oil, the synthetism wood oil, Oleum Santali albi, sandarac, sassafras oil, tumbling mustard oil (Sisymbrium Ino Oil), Oleum Menthae Rotundifoliae, Majorana hortensis oil, sweet violet vegetable oil, tar, thyme oil, vetiver oil, wild Oleum menthae, the sea sandalwood oil, Yarrow oils, Cananga odorata oil or their combination in any.

The preferred quintessence oil that the aromatotherapy benefit is provided that is used for topical composition of the present invention comprises one or more quintessence oils that are selected from chamomile oil, lavandin oil, Oleum lavandula angustifolia, oil of grapefruit, Fructus Citri Limoniae oil, white lemon oil, tangerine oil, orange blossom oil and orange oil.Chamomile oil can be used for promoting that pure and fresh and tempting fragrance also can provide the benefit of relieving stress to the user of described topical composition.Oleum lavandula angustifolia and lavandin can be used for the benefit that promotes pure and fresh and tempting fragrance and relieving stress can be provided the user of described topical composition.In oil of grapefruit, Fructus Citri Limoniae oil, white lemon oil, tangerine oil, orange blossom oil and the orange oil one or more provide pure and fresh Citrus flavor in use and can have the treatment benefit that can experience.

When using in the present invention, with respect to the gross weight of described compositions, these one or more quintessence oils that aromatotherapy benefit is provided exist with the amount of about 0.00001 weight %～about 1 weight %.Preferably, one or more quintessence oils that the aromatotherapy benefit is provided exist with the amount of about 0.00005 weight %～about 0.75 weight % of the gross weight of described compositions, and more preferably the amount with about 0.0001 weight %～about 0.5 weight % exists.Should be understood that, these provide one or more quintessence oils of aromatotherapy benefit to use with the optional fragrance components of describing before, perhaps do not use, and can completely or partially replace described fragrance components and use with described fragrance components.

Described topical composition can comprise one or more antioxidant ingredients.The example of antioxidant is including, but not limited to water soluble antioxidant such as sulfhydryl compound and derivant (for example sodium metabisulfite and N-acetyl-cysteine), thioctic acid and dihydrolipoic acid, resveratrol, lactoferrin, glutathion and ascorbic acid and ascorbic acid derivates (for example ascorbyl palmitate and ascorbic acid polypeptide).Be useful in oil-soluble inhibitor in the compositions of the present invention including, but not limited to Yoshinox BHT, retinoid, tocopherols for example tocopherol acetate and tocotrienol, and ubiquinone.Contain the natural extract that is useful in the antioxidant in the topical composition of the present invention including, but not limited to extract that contains flavone and isoflavonoid and derivant thereof and the extract that contains resveratrol etc.The example of this class natural extract comprises Semen Vitis viniferae, green tea, Cortex Pini Massonianae and propolis etc.When existing, with respect to be made of the wherein gross weight of the described topical composition of a part it, the gross weight of described antioxidant is no more than 5 weight % usually, and preferably the amount with 0.0001 weight %～4 weight % exists.In some preferred implementation, must there be one or more antioxidant ingredients.

Optionally, described topical composition can comprise one or more vitamin.The example of addible vitamin comprises vitamin A such as vitamin A oil, retinol, retinyl acetate and retinyl palmitate; Vitamin B comprises vitamin B ₂As riboflavin, Riboflavine Tertrabutyrate and flavin adenine nucleotide, vitamin B ₆Example hydrochloric acid pyridoxol, pyridoxol dicaprylate and pyridoxol tripalmitate, vitamin B ₁₂And derivant, and vitamin B ₁₅And derivant; Vitamin C is as L-ascorbic acid, L-Vitamin C dipalmitate, (L-ascorbic acid)-2-sodium sulfate and L-ascorbic acid diphosphonic acid dipotassium; Vitamin D is as ergocalciferol and cholecalciferol (cholecarciferol); Vitamin E is as alpha-tocopherol, betatocopherol, Gamma-Tocopherol, dl-alpha-tocopherol acetate, dl-Tocopheryl Nicotinate and dl-alpha-tocofecol succinic acid ester.When existing, according to some preferred implementation, one or more vitamin can comprise effective amount, with respect to be made of the wherein gross weight of the described compositions of a part vitamin, advantageously comprise 0.0001 weight %～1 weight %, preferably comprise 0.001 weight %～0.75 weight %.

Described topical composition can comprise one or more light stabilizers and UV absorbent.These materials are known to can be used in cosmetics or the topical composition and makes described compositions have to a certain degree stability, and described compositions can contain one or more and be exposed to the component that some light source for example can affect adversely when sunlight, fluorescence light source.The effect that may be present in the coloring agent in the described compositions can be stablized or improve to known other described materials.Can use to provide protection to prevent any cosmetic material or the chemical compound of its light degradation or photooxidative degradation for one or more components in the compositions of the present invention.

Exemplary light stabilizing agent and UV absorbent comprise: triazine comprises the s-triazine, pyrrolotriazine derivatives for example 2,4,6-three phenylaminos-(to carbon-2 '-ethyl-1 '-hexyloxy)-1,3,5-triazine, isomery triazine (anisotriazine), ethylhexyl triazinone, diethylhexyl butyrylamino triazinone, 2,4,6-three (diisobutyl 4 '-aminobenzene methylene maleate)-s-triazine and octyl triazone; Benzotriazole and derivant thereof, for example drometrizole trisiloxanes, ethylene (benzotriazole base) tetramethyl butyl phenol; Benzophenone cpd and derivant thereof for example 2-hydroxyl-4-methoxy benzophenone, 2-hydroxyl-4-methoxyl group-4 '-methyldiphenyl ketone, the 2-just own ester of (4-diethylamino-2-hydroxy benzoyl) benzoic acid and 2,2 '-dihydroxy-4-methoxy benzophenone and those materials of selling with trade name UVINUL by BASF at present; The sulfonic acid of benzophenone, for example 2-hydroxyl-4-methoxy benzophenone-5-sulfonic acid; The ester of benzylidene malonic acid, for example the 4-methoxybenzene methylene malonic acid 2-ethyl hexyl ester of benzylidene malonic acid; Benzoxazole derivative, for example 2,4-two [5-1 (dimethyl propyl) benzoxazole-2-base (4-phenyl) imino group]-6-(2-ethylhexyl) imino group-1,3,5-triazines; The sulfonic acid of 3-benzylidene camphene, for example 4-(the inferior bornyl methyl (bornylidenmethyl) of 2-oxygen-3-)-benzenesulfonic acid and 2-methyl-5-(2-oxygen-Ya bornyl) sulfonic acid; The ester of cinnamic acid and cinnamamide, cinnamic acid, for example ethylhexyl methoxy cinnamate, methoxy cinnamic acid isopropyl ester, methoxy cinnamic acid isopentyl ester, DEA Methoxycinnamate, diisopropyl methyl cinnamic acid ester, glycerol ethylhexoate dimethoxy-cinnamic acid ester, 4-methoxy cinnamic acid 2-ethyl hexyl ester, 4-methoxy cinnamic acid propyl diester, 4-methoxy cinnamic acid isopentyl ester, 2-cyano group-3,3-phenyl-cinnamic acid 2-ethyl hexyl ester (octocrilene); Propane-1,3-diketone, 1-(4-tert-butyl-phenyl)-3-(4 '-methoxyl group-phenyl)-propane-1 for example, 3-diketone; Phenyl benzimidazole and sulfonated benzimidazole imidazoles, for example 2-Phenylbenzimidazole-5-sulfonic acid, phenyl bisbenzimidazole tetrasulfonic acid disodium; Salicyclic acid derivatives (comprising salicylic ester), for example ethylhexyl salicylate, dipropylene glycol salicylate, TEA salicylate, salicylic acid 2-Octyl Nitrite, salicylic acid 4-cumene methyl ester, the high menthol ester of salicylic acid; Based on the derivant of chemical compound or this chemical compound of benzylidene Camphora, for example 3-benzylidene Camphora, 3-benzylidene norcamphor, 4-UVINUL MBC95, benzylidene camphorsulfonic acid, Camphora dimethyl sulfate benzalkonium, terephthaldehyde pitch two camphorsulfonic acids, polyacrylamide amino methyl benzylidene Camphora and derivant thereof; 4-amino benzoic Acid and derivant thereof, for example 4-(dimethylamino) benzoic acid 2-Octyl Nitrite, 4-(dimethylamino) benzoic acid 2-monooctyl ester and 4-(dimethylamino) amyl benzoate.Can be as any above material that acid provides with free acid form or as for example its alkali metal salt, alkali salt, ammonium salt, alkylammonium salt, the use of alkanol ammonium salt form of its salt.

Exemplary and the preferred described material of present commercially available acquisition comprises following one or more: CIBAFAST H liquid, and it is described to benzotriazole base butylphenol sodium sulfonate and butylol polyether-3 and tributyl citrate; TINOGARD HS, it is described to benzotriazole base butylphenol sodium sulfonate; TINOGARD AS, it is described to bumetrizole; TINOGARD TL, it is described to 124 Triazole dodecyl paracresol; And TINOGARD Q, it is described to three (tetramethyl hydroxy piperidine alcohol) citrate, at present these materials all can from Ciba SpecialtyChemicals (Muttenz, CH.) commercially available.Especially preferred this type of material is those products of selling with trade mark UVINUL (from BASF), and especially UVINUL MS 40.

When existing, described one or more light stabilizers and UV absorbent can comprise with any effective dose; Advantageously, with respect to formed the wherein gross weight of the described compositions of a part by it, these materials exist with the amount of 0.0001 weight %～1 weight %, and preferably the amount with 0.001 weight %～0.25 weight % exists.

For regulating the pH of compositions of the present invention, can in described compositions, comprise one or more pH regulator agent and one or more pH buffer agents with effective dose.As limiting examples, the pH regulator agent comprises phosphorus-containing compound, unit price and multivalent salts such as silicate, carbonate and borate, some bronsted lowry acids and bases bronsted lowry, tartrate and some acetate.Other exemplary pH regulator agent comprise mineral acid, alkaline compositions and organic acid, only need a spot of described pH regulator agent usually.As other limiting examples, the pH buffer compositions comprises alkali metal phosphate, polyphosphate, pyrophosphate, triphosphate, tetraphosphate, silicate, metasilicate, polysilicate, carbonate, hydroxide and their mixture.Some salt, for example alkali earth metal phosphate and carbonate, hydroxide also can be used as buffer agent.Also be suitable as buffer agent such as aluminosilicate (zeolite), borate, aluminate and some organic material such as materials such as gluconate, succinate, maleate and alkali salt thereof.When existing, described pH regulator agent, particularly pH buffer agent exist with the pH that keeps compositions of the present invention in required or target pH scope with effective dose.Advantageously, they usually with as the existing more on a small quantity of 0.001 weight %～1.5 weight %, but it is desirable to exist with the amount of 0.01 weight %～1 weight %.With reference to one or more following examples exemplary and preferred pH buffer agent and pH regulator agent are described.

Compositions of the present invention can comprise one or more chelating agen.Exemplary available chelating agen comprises those chelating agen known in the art, comprises the following chelating agen as limiting examples: aminopolycanboxylic acid and salt thereof are connected with plural substituent group on the wherein said amino nitrogen.Preferred chelating agen comprises acid and salt, particularly sodium salt and the potassium salt of ethylenediaminetetraacetic acid, diethylenetriamine pentaacetic acid, N-Oxyethylethylenediaminetriacetic acid, and the sodium salt that wherein adopts ethylenediaminetetraacetic acid is especially favourable.Can not contain these chelating agen, perhaps can contain less amount usually, as with as described in the weight of chelating agen and/or its salt form count 0.001 weight %～0.5 weight %.It is desirable to, the content of these chelating agen in compositions of the present invention is 0.01 weight %～0.5 weight %, but it would be desirable the less percentage by weight of about 0.01 weight %～0.2 weight %.

As mentioned above, compositions of the present invention in fact mainly is an aqueous.Add water so that compositions of the present invention reaches 100 weight %.Described water can be tap water, but is preferably distilled water, and most preferably is deionized water or " soft " water.If described water is tap water, then it does not preferably contain any objectionable impurities such as Organic substance or inorganic matter substantially, especially is present among the hard water thereby may causes the effect of the component that exists in the topical composition of the present invention the inorganic salt of adverse effect.Water constitutes the major part of compositions of the present invention, and, with respect to formed the wherein gross weight of the described topical composition of a part by it, water must exist with the amount of at least 50 weight %, the amount that is preferably with at least 60 weight % exists, more preferably the amount with at least 65 weight % exists, and then more preferably exists with the amount of 70 weight %.

In another aspect, the present invention has also imagined to be provided cleaning and/or the method for antimicrobial benefit is provided skin or other local surfaces, and described method has been imagined with cleaning and/or antimicrobial effective dose and come local application aqueous foaming topical compositions as described here.Preferably, provide persistent antimicrobial benefit according to said method to skin or other local surfaces of applying said compositions.

Though the main uses of topical composition disclosed herein is to be applied to skin and provides cleaning and/or antimicrobial benefit to be provided to it and to be envisioned at the allotter that is used for this processing, but should be understood that, it should be interpreted as restricted qualification, and other forms of compositions of the present invention and other purposes all clearly are envisioned within the scope of the present invention as facial cleanser, emulsion, emulsifiable paste, facial cleansing cream, massage material, liquid toilet cleaning soap and hair products such as shampoo, Rinsing or other hairs or scalp care product.Topical composition of the present invention can be formulated as washing liquid, cream or gel, and it can be transparent, translucent or opaque.Some preferred embodiment in, described topical composition is as translucent or clear composition, being preferably clear composition provides.

Described compositions can be packaged in the suitable containers that the desired use with its viscosity and consumer matches.For example, washing liquid or emulsifiable paste can be packaged in the bottle, perhaps can be packaged together in the propellant actuated aerosol device with propellant or can be packaged in the container that disposes manual pump.Compositions of the present invention can provide and be kept in the non-distortion bottle, but more preferably, and if can be distributed easily by consumer in the pipe of described compositions or the deformable bottle at squeezable container provides.Therefore, the closed container that compositions of the present invention described herein is housed that provides on the one hand more of the present invention.

What also it should be clearly understood that is that the local application of described topical composition disclosed herein can be applied to any part of skin or health, comprises skins such as face, cervical region, chest, back, arm, axillary fossa, hand, shank and scalp.Topical composition disclosed herein also can be used for hair.

Be envisioned in use, user takes out a certain amount of topical composition described herein and it is applied to any other parts of skin or health, preferably before using described topical composition with site of administration with water-wet (for example flushing).User can rub described topical composition to produce soap bubble or foam at the skin of being used or other part places of health, can be contemplated that thereafter user can wash treated zone with flowing water flow when shower (for example) or by immersing in the water when bath in a tub (for example).After this, also imagining other parts of the skin of user or health can be through air-dry or use one or more towel to sop up unnecessary moisture content.Therefore, another aspect of the present invention relates to the application of foaming topical compositions described herein.

The specific embodiment

Following examples have been described exemplary formulation of the present invention and preferred implementation.Should be understood that these embodiment only provide in the mode of describing, those skilled in the art can make easily and drop on other the useful preparations within the present invention and the claims scope and do not depart from scope and spirit of the present invention.

Embodiment

The of the present invention many topical compositions that make according to the present invention described below prepare according to following general program:

To being equipped with Routine Test Lab to add 65 ℃～70 ℃ deionized water or soft water of amount with agitator, in the first suitable container of the unlimited size of air through measuring.Under agitation in water, add thickener component subsequently, it is mixed until evenly,, be mixed to few 30 minutes after having added described anion surfactant after this succeeded by adding anion surfactant.

Simultaneously, to equally opening wide and be equipped with another laboratory to add 65 ℃～70 ℃ deionized water or soft water of another equal portions in the second suitable container of the size of agitator to air, under agitation in this water, add antimicrobial components and cosurfactant component (if existence), and stir continuously until obtaining uniform mixture.Described anion surfactant has mixed at least 30 minutes in first container after, the content of second container is under agitation added in first container.

To equally opening wide and be equipped with another laboratory to add 65 ℃～70 ℃ deionized water or soft water of another equal portions in the 3rd suitable container of the size of agitator to air, under agitation in this water, add ethylene glycol and salicylic acid, and stir to mix, until the mixture that makes homogenizing.Then, the content of the 3rd container is under agitation added in first container of uniform homogeneous blend of the content that has first and second containers.

To equally to air open wide and be equipped with another laboratory with the 4th suitable container of the size of agitator in, 65 ℃～70 ℃ deionized water or soft water adding another equal portions, under agitation in this water, add such as any buffer agent and chelating agen such as citric acid, citric acid dehydrates, until the mixture that makes homogenizing.Next, the content of the 4th container under agitation added have, in first container of the uniform homogeneous blend of the content of the second and the 3rd container, after this, the content of first container under agitation is cooled to 40 ℃, subsequently to wherein adding any aromatic, antiseptic or coloring agent (dyestuff, pigment) component, and homogenize.Obtain target viscosities if desired, then can in the compositions in stirring, add sodium chloride.Then, the speed of agitator is slowed to minima, and under this condition, add the cosmetics particulate constituent in the compositions in first container, and make among its this bulk phase that is evenly dispersed in topical composition.The pH of the topical composition during assessment mixes if desired, can under agitation add a spot of acid or alkali, is adjusted into 4～4.5 with the pH with compositions.

Shown in following table 1 and table 2, in following compositions, each component is used with state that its respective vendor was provided, and it may contain " active matter " that is less than 100 weight %, and perhaps the form with " active matter " that contain 100 weight % appointed compounds provides.

Every kind of compositions comprises " capacity " deionized water (q.s.) so that concrete compositions reaches 100 weight portions.

^*Use Brookfield PV-III type viscometer when 6rpm moves, to measure in room temperature (about 20 ℃) with No. 63 rotors

Be used to make described in the characteristic such as following table 2 of concrete component of the foregoing description.In some preparation, find to add a spot of sodium chloride and help controlling the thickening degree of final composition, thereby help the final viscosity of control combination thing.

Stability test:

In the compositions of different temperatures, to estimate its storage stability with different time interval evaluation table 1.

Add the compositions of equal portions in vial to transparent laboratory,, and under indicated room temperature and hot conditions, store described bottle sealing through measuring.With the test the visualization outcome record in following table.

Compositions to the equal portions through measuring is carried out the freeze-thaw stability evaluation, wherein, room temperature (68,20 ℃), freezing and make it restore to room temperature after and the characteristic of observing described compositions at 4 ℃ low temperature.

The outcome record of described test is in following table 3.

Antimicrobial efficacy:

The topical anti-microbial effect of estimating compositions of the present invention is tested in---chemosterilant and antibacterial---antimicrobial acivity evaluation with quantitative suspension according to EN12054.This test is used for estimating tested compositions in health and the surgery antimicrobial efficacy of wiping away hands liquid (handrub) and handwashing liquid application.

According to EN12054, the compositions that pH is adjusted to the disclosed embodiments 1 in 4.35 the as above table 1 is estimated.For every kind of aggressivity organism, in each test, carry out parallel assay twice.Following table 4 has write down the log that is realized for same aggressivity organism ₁₀Reduce and log minimizing %.

Foregoing shows that the compositions display of embodiments of the invention 1 goes out excellent antimicrobial acivity.

The present invention is easy to adopt various modification and alternative form, but should be understood that, is not to be intended to the present invention is limited to disclosed concrete form by the specific embodiment of the present invention shown in the by way of example; On the contrary, its purpose is to contain and drops on as represented scope of the present invention of claims and all modifications form, equivalents and the alternative form within the main idea.

Claims

1. aqueous topical composition that the topical anti-microbial benefit is provided, described compositions comprises:

Optional but preferred cosurfactant component, preferred especially beet alkali surface activator;

Thickener system, described thickener system must comprise polyacrylate cross linked polymer thickener component and one or more polysaccharide polymers, described polysaccharide polymer is selected from xanthan gum, guar gum, locust bean gum, Tragacanth or their derivant, particularly guar gum or guar derivative;

Antimicrobial components, described antimicrobial components must comprise salicylic acid, Salicylate or salicylate and be highly resistant to gram negative bacteria and/or at least a other antimicrobially active compounds or the material of gram positive bacteria;

The cosmetics particulate constituent;

Optional one or more selectable components, described selectable components can be used for making described topical composition have the aesthetics of one or more expectations or technical benefits and with other component compatibility that are present in described compositions;

Wherein, described topical composition has acid pH, preferably has about pH below 5, and in addition, wherein said compositions is 25 ℃ of viscosity that show at least about 500 centipoises.

2. aqueous topical composition as claimed in claim 1, described compositions is 25 ℃ of viscosity that show at least about 1000 centipoises.

3. aqueous topical composition as claimed in claim 1, described compositions is 25 ℃ of viscosity that show at least about 2000 centipoises.

4. aqueous topical composition as claimed in claim 1, described compositions is 25 ℃ of viscosity that show at least about 3000 centipoises.

5. aqueous topical composition as claimed in claim 1, described compositions is 25 ℃ of viscosity that show at least about 9000 centipoises.

6. aqueous topical composition as claimed in claim 1, wherein, described cosmetics particulate constituent shows at least 70 ℃ fusing point.

7. aqueous topical composition as claimed in claim 1, wherein, described cosmetics particulate constituent shows at least 100 ℃ fusing point.