CN101628079A - Medicinal composition used for treating male sterility and preparation method thereof - Google Patents
Medicinal composition used for treating male sterility and preparation method thereof Download PDFInfo
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- CN101628079A CN101628079A CN200810116838A CN200810116838A CN101628079A CN 101628079 A CN101628079 A CN 101628079A CN 200810116838 A CN200810116838 A CN 200810116838A CN 200810116838 A CN200810116838 A CN 200810116838A CN 101628079 A CN101628079 A CN 101628079A
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Abstract
The invention provides a medicinal composition used for treating male sterility and a preparation method thereof. The composition is prepared from the following raw materials in proportion by weight: 10 to 30 portions of desertliving cistanche, 5 to 30 portions of epimedium herb, 10 to 30 portions of medicinal indianmulberry root, 5 to 30 portions of epimedium, 5 to 20 portions of prepared common monkshood daughter root, 5 to 20 portions of cassia bark, 5 to 20 portions of common macrocarpium fruit, 5 to 20 portions of barbary wolfberry fruit, 5 to 20 portions of common yam rhizome, 5 to 20 portions of Chinese magnoliavine fruit , 5 to 15 portions of common curculigo rhizome, 5 to 30 portions of cooked rehmannia root, 5 to 20 portions of manyflower solomonseal rhizome, 5 to 20 portions of tuber fleeceflower root , 5 to 20 portions of Chinese angelica and 5 to 20 portions of eucommia bark which can be made into clinically acceptable medicinal preparations through adopting modern preparation techniques. The medicinal composition has the efficacies of supplementing kidney yang, boosting essence blood and nourishing yin and invigorating yang, and is used to treat male sterility, limp aching lumbus and knees, impotence and premature ejaculation, fatigued spirit and lack of strength, and other diseases caused by deficiency of the kidney yang.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition and preparation method thereof, particularly relate to a kind of pharmaceutical composition for the treatment of male sterility and preparation method thereof, belong to the novel technique field.
Background technology
In recent years, people from portion survey data shows that the ratio of male sterility is the trend of rising among the married crowd of China.
The paathogenic factor of male sterility is very complicated, and is relevant with factors such as weakness due to chronic disease, intemperate sexual intercourse and environment, bad life habits, operating pressures.
The male sterility clinical manifestation is sterile for a long time for wedding, often with impotence and premature ejaculation, and soreness of the waist and knees, symptoms such as lethargy not only influence patient's body quality of life, and have a strong impact on goodwill as between spouses, family harmony, concerning China's population quality and safety, should cause that various circles of society pay much attention to.
Summary of the invention
One of the object of the invention is to provide a kind of pharmaceutical composition for the treatment of male sterility, and this pharmaceutical composition has kidney-replenishing, benefiting essence-blood, and the effect of YIN nourishing and YANG strengthening is used for the disease such as male sterility, soreness of the waist and knees, impotence and premature ejaculation, spiritlessness and weakness due to the insufficiency of kidney-YANG.
Two of the object of the invention is to provide this preparation of drug combination method.
The pharmaceutical composition of treatment male sterility provided by the invention is on the experiential basis of clinical treatment infertility for many years, selected Chinese crude drug with kidney-replenishing, benefiting essence-blood, controlling nocturnal emission with astringent drugs reducing urination, effect of warming kidney and strengthening yang, through the science compatibility, adopt modern preparation technique, be processed into acceptable drug preparation clinically, as tablet, capsule, granule, syrup, oral liquid, soft capsule, the arbitrary dosage form of pill.
The pharmaceutical composition of treatment male sterility provided by the invention is to be made by following raw materials by weight proportions:
Herba Cistanches 10～30 weight portion Herba Epimedii 5～30 weight portions
Radix Morindae Officinalis 10～30 weight portion Herba Epimedii 5～30 weight portions
Radix Aconiti Lateralis Preparata 5～20 weight portion Cortex Cinnamomis 5～20 weight portions
Fructus Corni 5～20 weight portion Fructus Lycii 5～20 weight portions
Rhizoma Dioscoreae 5～20 weight portion Fructus Schisandrae Chinensis 5～20 weight portions
Rhizoma Curculiginis 5～15 weight portion Radix Rehmanniae Preparata 5～30 weight portions
Rhizoma Polygonati 5～20 weight portion Radix Polygoni Multiflori 5～20 weight portions
Radix Angelicae Sinensis 5～20 weight portion Cortexs Eucommiae 5～20 weight portions
Further, the pharmaceutical composition of treatment male sterility provided by the invention can be adopted as following raw materials by weight proportions especially and make:
Herba Cistanches 30 weight portion Herba Epimedii 20 weight portions
Radix Morindae Officinalis 20 weight portion Herba Epimedii 15 weight portions
Radix Aconiti Lateralis Preparata 10 weight portion Cortex Cinnamomis 15 weight portions
Fructus Corni 10 weight portion Fructus Lycii 10 weight portions
Rhizoma Dioscoreae 10 weight portion Fructus Schisandrae Chinensis 15 weight portions
Rhizoma Curculiginis 10 weight portion Radix Rehmanniae Preparata 15 weight portions
Rhizoma Polygonati 10 weight portion Radix Polygoni Multiflori 10 weight portions
The Radix Angelicae Sinensis 10 weight portion Cortexs Eucommiae 10 weight portions
The preparation of drug combination method of treatment male sterility provided by the invention is as follows:
(1) gets Herba Cistanches, Herba Epimedii, Fructus Corni, Fructus Schisandrae Chinensis, be ground into coarse powder, measure 50%～95% alcohol reflux 2～3 times with 6～10 times, each 1～3 hour, extract pure liquid and filter merging filtrate, decompression recycling ethanol and to be concentrated into relative density be 1.10～1.35 clear paste, standby; Medicinal residues are waved diffusing ethanol, and are standby;
(2) get Radix Morindae Officinalis, Herba Epimedii, Radix Aconiti Lateralis Preparata, Cortex Cinnamomi, Fructus Lycii, Rhizoma Dioscoreae, Rhizoma Curculiginis, Radix Rehmanniae Preparata, Rhizoma Polygonati, Radix Polygoni Multiflori, Radix Angelicae Sinensis, the Cortex Eucommiae, be ground into coarse powder, add above-mentioned medicinal residues, decoct 2～3 times with 8～12 times of water gagings, each 1～2 hour, decocting liquid filtered, merging filtrate, be evaporated to relative density and be 1.10～1.35 clear paste, standby;
(3) get above-mentioned clear paste, merge, formulation method adds pharmaceutical adjunct routinely, molding, and packing, check, promptly.
The specific embodiment
Embodiment 1
Prescription is formed:
Herba Cistanches 150g Herba Epimedii 100g Radix Morindae Officinalis 100g Herba Epimedii 75g
Radix Aconiti Lateralis Preparata 50g Cortex Cinnamomi 75g Fructus Corni 50g Fructus Lycii 50g
Rhizoma Dioscoreae 50g Fructus Schisandrae Chinensis 75g Rhizoma Curculiginis 50g Radix Rehmanniae Preparata 75g
Rhizoma Polygonati 50g Radix Polygoni Multiflori 50g Radix Angelicae Sinensis 50g Cortex Eucommiae 50g
Dextrin 55g
Make 1000 altogether
Preparation method:
(1) gets Herba Cistanches, Herba Epimedii, Fructus Corni, Fructus Schisandrae Chinensis, be ground into coarse powder,, extract pure liquid and filter with 10 times of amount 85% alcohol reflux 2 hours; Medicinal residues add 8 times of amount 85% alcohol reflux 2 hours, extract pure liquid and filter; Medicinal residues add 8 times of amount 85% alcohol reflux 2 hours again, extract pure liquid and filter; Merging filtrate, decompression recycling ethanol and to be concentrated into relative density be 1.25 clear paste, standby; Medicinal residues are waved diffusing ethanol, and are standby;
(2) get Radix Morindae Officinalis, Herba Epimedii, Radix Aconiti Lateralis Preparata, Cortex Cinnamomi, Fructus Lycii, Rhizoma Dioscoreae, Rhizoma Curculiginis, Radix Rehmanniae Preparata, Rhizoma Polygonati, Radix Polygoni Multiflori, Radix Angelicae Sinensis, the Cortex Eucommiae, be ground into coarse powder, add above-mentioned medicinal residues, decocted 2 hours with 12 times of water gagings, decocting liquid filters; Medicinal residues add 10 times of water gagings and decocted 1.5 hours, and decocting liquid filters; Medicinal residues add 10 times of water gagings again and decocted 1 hour, and decocting liquid filters, and merging filtrate is evaporated to relative density and is 1.25 clear paste, and is standby;
(3) get above-mentioned clear paste, merge, drying is ground into fine powder, gets dry extract, and is standby;
(4) get above-mentioned dry extract, add dextrin, mix homogeneously, the magnesium stearate of adding 0.4%, mix homogeneously, encapsulated, packing, check, promptly.
Embodiment 2
Prescription is formed:
Herba Cistanches 150g Herba Epimedii 100g Radix Morindae Officinalis 100g Herba Epimedii 75g
Radix Aconiti Lateralis Preparata 50g Cortex Cinnamomi 75g Fructus Corni 50g Fructus Lycii 50g
Rhizoma Dioscoreae 50g Fructus Schisandrae Chinensis 75g Rhizoma Curculiginis 50g Radix Rehmanniae Preparata 75g
Rhizoma Polygonati 50g Radix Polygoni Multiflori 50g Radix Angelicae Sinensis 50g Cortex Eucommiae 50g
Starch 150g
Make 1000 altogether
Preparation method:
(1) gets Herba Cistanches, Herba Epimedii, Fructus Corni, Fructus Schisandrae Chinensis, be ground into coarse powder,, extract pure liquid and filter with 10 times of amount 85% alcohol reflux 2 hours; Medicinal residues add 10 times of amount 85% alcohol reflux 2 hours, extract pure liquid and filter; Medicinal residues add 10 times of amount 85% alcohol reflux 2 hours again, extract pure liquid and filter; Merging filtrate, decompression recycling ethanol and to be concentrated into relative density be 1.20 clear paste, standby; Medicinal residues are waved diffusing ethanol, and are standby;
(2) get Radix Morindae Officinalis, Herba Epimedii, Radix Aconiti Lateralis Preparata, Cortex Cinnamomi, Fructus Lycii, Rhizoma Dioscoreae, Rhizoma Curculiginis, Radix Rehmanniae Preparata, Rhizoma Polygonati, Radix Polygoni Multiflori, Radix Angelicae Sinensis, the Cortex Eucommiae, be ground into coarse powder, add above-mentioned medicinal residues, decocted 2 hours with 12 times of water gagings, decocting liquid filters; Medicinal residues add 10 times of water gagings and decocted 1.5 hours, and decocting liquid filters; Medicinal residues add 10 times of water gagings again and decocted 1 hour, and decocting liquid filters, and merging filtrate is evaporated to relative density and is 1.20 clear paste, and is standby;
(3) get above-mentioned clear paste, merge, add starch, mix homogeneously is made granule, drying, and granulate gets granule, and is standby;
(4) get above-mentioned granule, add 0.5% magnesium stearate, mix homogeneously, packing, packing, check, promptly.
Claims (3)
1, the pharmaceutical composition of treatment male sterility is characterized in that this pharmaceutical composition is to be made by following raw materials by weight proportions:
Herba Cistanches 10～30 weight portion Herba Epimedii 5～30 weight portions
Radix Morindae Officinalis 10～30 weight portion Herba Epimedii 5～30 weight portions
Radix Aconiti Lateralis Preparata 5～20 weight portion Cortex Cinnamomis 5～20 weight portions
Fructus Corni 5～20 weight portion Fructus Lycii 5～20 weight portions
Rhizoma Dioscoreae 5～20 weight portion Fructus Schisandrae Chinensis 5～20 weight portions
Rhizoma Curculiginis 5～15 weight portion Radix Rehmanniae Preparata 5～30 weight portions
Rhizoma Polygonati 5～20 weight portion Radix Polygoni Multiflori 5～20 weight portions
Radix Angelicae Sinensis 5～20 weight portion Cortexs Eucommiae 5～20 weight portions.
2, the pharmaceutical composition of treatment male sterility as claimed in claim 1 is characterized in that this pharmaceutical composition is to be made by following raw materials by weight proportions:
Herba Cistanches 30 weight portion Herba Epimedii 20 weight portions
Radix Morindae Officinalis 20 weight portion Herba Epimedii 15 weight portions
Radix Aconiti Lateralis Preparata 10 weight portion Cortex Cinnamomis 15 weight portions
Fructus Corni 10 weight portion Fructus Lycii 10 weight portions
Rhizoma Dioscoreae 10 weight portion Fructus Schisandrae Chinensis 15 weight portions
Rhizoma Curculiginis 10 weight portion Radix Rehmanniae Preparata 15 weight portions
Rhizoma Polygonati 10 weight portion Radix Polygoni Multiflori 10 weight portions
The Radix Angelicae Sinensis 10 weight portion Cortexs Eucommiae 10 weight portions.
3, the preparation of drug combination method of treatment male sterility as claimed in claim 1 or 2 is as follows:
(1) gets Herba Cistanches, Herba Epimedii, Fructus Corni, Fructus Schisandrae Chinensis, be ground into coarse powder, measure 50%～95% alcohol reflux 2～3 times with 6～10 times, each 1～3 hour, extract pure liquid and filter merging filtrate, decompression recycling ethanol and to be concentrated into relative density be 1.10～1.35 clear paste, standby; Medicinal residues are waved diffusing ethanol, and are standby;
(2) get Radix Morindae Officinalis, Herba Epimedii, Radix Aconiti Lateralis Preparata, Cortex Cinnamomi, Fructus Lycii, Rhizoma Dioscoreae, Rhizoma Curculiginis, Radix Rehmanniae Preparata, Rhizoma Polygonati, Radix Polygoni Multiflori, Radix Angelicae Sinensis, the Cortex Eucommiae, be ground into coarse powder, add above-mentioned medicinal residues, decoct 2～3 times with 8～12 times of water gagings, each 1～2 hour, decocting liquid filtered, merging filtrate, be evaporated to relative density and be 1.10～1.35 clear paste, standby;
(3) get above-mentioned clear paste, merge, formulation method adds pharmaceutical adjunct routinely, molding, and packing, check, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810116838A CN101628079A (en) | 2008-07-18 | 2008-07-18 | Medicinal composition used for treating male sterility and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810116838A CN101628079A (en) | 2008-07-18 | 2008-07-18 | Medicinal composition used for treating male sterility and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101628079A true CN101628079A (en) | 2010-01-20 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200810116838A Pending CN101628079A (en) | 2008-07-18 | 2008-07-18 | Medicinal composition used for treating male sterility and preparation method thereof |
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| CN (1) | CN101628079A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104740123A (en) * | 2015-03-11 | 2015-07-01 | 雷少华 | Traditional Chinese medicine mixture for treating impotence |
| CN106177789A (en) * | 2016-08-29 | 2016-12-07 | 徐焕柱 | A kind of Chinese medicine preparation treating male sterility |
| CN112891505A (en) * | 2021-04-25 | 2021-06-04 | 曾雨晴 | Spleen-tonifying and kidney-tonifying composition, preparation method and application thereof |
-
2008
- 2008-07-18 CN CN200810116838A patent/CN101628079A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104740123A (en) * | 2015-03-11 | 2015-07-01 | 雷少华 | Traditional Chinese medicine mixture for treating impotence |
| CN106177789A (en) * | 2016-08-29 | 2016-12-07 | 徐焕柱 | A kind of Chinese medicine preparation treating male sterility |
| CN112891505A (en) * | 2021-04-25 | 2021-06-04 | 曾雨晴 | Spleen-tonifying and kidney-tonifying composition, preparation method and application thereof |
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Open date: 20100120 |