CN101606715A - A kind of preparation method who disturbs anionic food-grade amino acid ferrous chelate compound that do not contain - Google Patents
A kind of preparation method who disturbs anionic food-grade amino acid ferrous chelate compound that do not contain Download PDFInfo
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- CN101606715A CN101606715A CNA200810062256XA CN200810062256A CN101606715A CN 101606715 A CN101606715 A CN 101606715A CN A200810062256X A CNA200810062256X A CN A200810062256XA CN 200810062256 A CN200810062256 A CN 200810062256A CN 101606715 A CN101606715 A CN 101606715A
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Abstract
Disturb anionic food-grade amino acid ferrous chelate compound preparation method a kind of not containing, it selects for use amino acid and source of iron as primary raw material, it is characterized in that selecting for use glycine, methionine, glutamic acid, lysine etc. as amino acid starting material, select for use pure iron element, ferrocyanide, ferrous hydroxide and ferrous carbonate etc. to be source of iron, amino acid and source of iron reaction mol ratio are 1: 1～6: 1; Amino acid is dissolved in the water; add source of iron; non-interference anion reducing agent or complex reducing agent are added in nitrogen protection down; as citric acid, ascorbic acid, acetate, carbonic acid etc.; regulate pH value 3～8; be heated to 40-100 ℃; stirring reaction 5～70 hours; evaporation and concentration; 50～100% ethanol waters extractions, also directly spray-drying or roller drying obtain required product; can add auxiliary agents such as maltodextrin, cyclodextrin in the product, have product and do not contain the characteristics such as anion, ferrous content height, preparation technology are simple of disturbing.
Description
Technical field:
The present invention relates to a kind of preparation technology who disturbs anionic food enrichment amino acid ferrous chelate compound that do not contain.
Background technology
Iron is a kind of important trace element that needed by human body is wanted, and is closely related with the manufacturing of ferroheme, myoglobins and cytochromes.According to the report of WHO (World Health Organization), the about 2,000,000,000 population anaemias in the present whole world, asiderosis is the most general nutritive disease in a kind of whole world.In China, the iron deficiency phenomenon is also very general, and among some regional infant and the students in middle and primary schools, Patients with iron deficiency anemia is up to 64.4%.As seen, asiderosis and hypoferric anemia are extremely serious problems.
In diet, on the one hand the iron in the food when the small intestine film absorbs, easily with material formation infusible precipitates such as oxalates, phytates, the absorptivity of reduction iron; On the other hand in the food ferrous ion ratio seldom, and unstable, very easily be oxidized to the ferric ion that is difficult for by human body absorbed.Studies show that the dipeptides complex compound that amino acid becomes with the ferrous ion chelating enters mucomembranous cell in the mode of active transport from enteron aisle, can directly be absorbed by human body by small intestine, perhaps in other words, iron can enter enteron aisle as carrier molecule by amino acid.Improve absorptivity greatly, and mouthfeel is good, little to GI excitant, side effect is little, in microelement-supplementing, can also replenish the amino acid of needed by human,, youth adult to treating and children's hypoferric anemia is very effective, it is a kind of comparatively desirable iron supplement nutritional enhancer, as glycine relative molecular mass minimum in amino acid, glycin chelated iron is easier to be absorbed by the body and to utilize, ferrous bisglycinate chelate compound assimilation effect is 2.3 times of ferrous glycine compound, and both all are better than ferrous sulfate.
China's the mid-80, the amino acid ferrous chelate compound that begins one's study has been obtained certain progress now.But amino acid ferrous chelate compound mainly is a feed addictive, and is also rare as food enrichment.Commercially available amino acid-ferrous product major part contains " disturbing anion ", for example, be in the feedstock production ferrous bisglycinate chelate with the ferrous sulfate, metal sulfate and amino acid are difficult to react completely, with the frerrous chloride is in the feedstock production, and frerrous chloride and chelating amino acids reaction also are difficult to carry out fully.Sulfate ion separates very difficultly in the product with chlorion, and these disturb anion to cause obtaining the ferrous bisglycinate chelate product of high Fe content, and human body is had harm, must spends the salt that a large amount of costs is handled these difficulty separation.
This patent adopts an amount of pure iron element, ferrocyanide, ferrous hydroxide and ferrous carbonate etc. and pure amino acid, dipeptides, polypeptide or protein hydrolysate, and add non-interference anion reducing agent, as ascorbic acid, acetate, citric acid etc., under suitable liquid condition, react, metal and amino acid are interacted, form the amino acid ferrous chelate compound that contains reducing agent.
Reducing agent is not only protected ferrous not oxidized and nutritious value in the amino acid ferrous chelate compound, and in addition, amino acid ferrous chelate compound provides one to replenish amino acid whose source, and this also helps keeping fit.
Summary of the invention:
The objective of the invention is to overcome and disturb anionic influence, provide a kind of preparation technology simply, not contain to disturb anion, food-grade amino acid ferrous chelate compound preparation technology easy to utilize.This method is: react in solution by amino acid and source of iron and make; this source of iron comprises in pure iron element, ferrocyanide, ferrous hydroxide and the ferrous carbonate etc. to be selected; logical nitrogen protection in the chelatropic reaction process; and add non-interference anion reducing agent or complex reducing agent, there is reaction down as ascorbic acid, acetate, citric acid, carbonic acid etc.These materials are useful, can be used as buffer and stop amino acid ferrous chelate compound to be destroyed by the acid medium in the stomach in intestines and stomach, make them directly enter small intestine and are absorbed; At last, separate unnecessary source of iron, adopt ethanolic solution to precipitate and wash-out, amino acid ferrous chelate compound in the product and unreacted amino acid are separated, also directly spray-drying or roller drying, obtain the amino acid ferrous chelate compound product, in spray-drying or roller dry run, also can add auxiliary agents such as maltodextrin.
Term " is interfered anion ", is meant sulfate, nitrate, chloride etc., and these anion not only have drawback, and is considered to can absorb by interfering ion in biosystem.For example, sulfate ion is considered to disturb by human and animal's intestinal walls the absorption of amino-acid chelate, clearly, there is multiple reason not absorb these amino-acid chelates, on the other hand, anion such as citric acid, ascorbate, heavy carbonate and similar salt are not " interfering anion ", but useful.In intestines and stomach, thereby they can be used as buffer and stop amino-acid chelate to be destroyed by the acid medium in the stomach to make them directly enter small intestine and be absorbed.
Do not contain the interference anion in the synthetic product of this method, amino acid ferrous chelate compound ferrous content height, reconstitution rate be greater than 95%, and oxidation stability, aqueous stability are good.Preparation technology of the present invention is simple, is convenient to industrial-scale production, and cost is lower, and the product physicochemical property is stable.
The specific embodiment:
Below in conjunction with accompanying drawing and specific embodiment, the present invention will be described in detail, and specific embodiment is seen shown in the accompanying drawing 1.
Embodiment 1
Select glycine and reduced iron powder as primary raw material, mol ratio is 1: 1; Earlier glycine is dissolved in the water, nitrogen protection adds reduced iron powder down, is 6 with the lemon acid for adjusting pH value; Water-bath is heated to 40 ℃, stirs reaction down 24 hours; The centrifugation reduced iron powder, evaporation and concentration is the extraction of 90% ethanol water with concentration, and drying obtains food-grade Ferrous glycinate product, and ferrous content is 17%.
Embodiment 2
Select for use glycine and ferrous hydroxide as primary raw material, mol ratio is 2: 1; Earlier glycine is dissolved in the water, nitrogen protection adds fresh ferrous hydroxide down, and regulating the pH value with ascorbic acid is 6; Be heated to 60 ℃, stir reaction down 48 hours; After evaporation and concentration to a small amount of solid is separated out, be the extraction of 70% ethanol water with concentration, drying obtains food-grade Ferrous glycinate product, and ferrous content is 16%.
Embodiment 3
Select for use methionine and ferrous carbonate as primary raw material, molar ratio is 2: 1; Earlier glycine is dissolved in the water, nitrogen protection adds fresh ferrous carbonate down, and regulating the pH value with ascorbic acid is 5, is heated to 70 ℃, under agitation reacts 18 hours; Evaporation and concentration, the roller drying obtains food-grade Ferrous glycinate product.
Embodiment 4
Select for use methionine and ferrous hydroxide as primary raw material, mol ratio is 2: 1; Earlier glycine is dissolved in the water, under nitrogen protection, adds fresh ferrous hydroxide, add an amount of ascorbic acid, be heated to 50 ℃, under agitation reacted 40 hours; Evaporation and concentration, spray-drying obtains food-grade ferrous methionine chelate product.
Embodiment 5
Select for use glycine and ferrous hydroxide as primary raw material, mol ratio is 2: 1; Earlier glycine is dissolved in the water, adds fresh ferrous hydroxide under nitrogen protection, add citric acid, consumption is 1/10th of a glycine weight, is heated to 50 ℃, under agitation reacts 50 hours; Evaporation and concentration, spray-drying is added a certain amount of maltodextrin, obtains food-grade Ferrous glycinate product, and ferrous content is 18%.
Embodiment 6
Select for use glycine and reduced iron powder as primary raw material, mol ratio is 1.5: 1; Earlier glycine is dissolved in the water, under nitrogen protection, adds reduced iron powder, be 5 with the lemon acid for adjusting pH value after, be heated to 50 ℃, under agitation reacted 72 hours; Separate iron powder, evaporation and concentration, spray-drying obtains food-grade Ferrous glycinate product, and ferrous content is 18%.
Claims (5)
1. one kind does not contain the preparation method who disturbs anionic food-grade amino acid ferrous chelate compound, it selects for use amino acid and source of iron as primary raw material, it is characterized in that selecting for use glycine, methionine, glutamic acid, lysine etc. as amino acid starting material, select for use pure iron element, ferrocyanide, ferrous hydroxide and ferrous carbonate etc. to be source of iron, the reaction molar ratio of amino acid and source of iron is 1: 1～6: 1; Amino acid is dissolved in the water, adds source of iron, nitrogen protection is added non-interference anion reducing agent or complex reducing agent down, as citric acid, ascorbic acid, acetate, carbonic acid etc., regulates the pH value 3～8, is heated to 40-100 ℃, stirs reaction down 5～70 hours; Evaporation and concentration, with concentration is 50～100% ethanol waters extractions, and directly spray-drying or roller drying are not contained the anionic food-grade amino acid ferrous chelate compound product of interference yet, in spray-drying or roller dry run, can add auxiliary agents such as maltodextrin;
2. according to the right 1 described preparation method who disturbs anionic food-grade amino acid ferrous chelate compound that do not contain, it is characterized in that selecting for use glycine, methionine, glutamic acid, lysine etc. as amino acid starting material;
3. according to the right 1 described preparation method who disturbs anionic food-grade amino acid ferrous chelate compound that do not contain, it is characterized in that selecting for use pure iron element, ferrocyanide, ferrous hydroxide and ferrous carbonate etc. to be source of iron, the reaction molar ratio of amino acid and iron is 1: 1～6: 1;
4. according to the right 1 described preparation method who disturbs anionic food-grade amino acid ferrous chelate compound that do not contain, it is characterized in that adding under the nitrogen protection non-interference anion reducing agent or complex reducing agent, as citric acid, ascorbic acid, acetate, carbonic acid etc., and regulate the pH value 3～8;
5. according to the right 1 described preparation method who disturbs anionic food-grade amino acid ferrous chelate compound that do not contain, after it is characterized in that chelatropic reaction, evaporation and concentration, with concentration is the extractions of 50～100% ethanol waters, also directly the method for spray-drying or roller drying obtains the amino acid ferrous chelate compound product, in spray-drying or roller dry run, can add auxiliary agents such as maltodextrin, do not contained and disturbed anionic food-grade amino acid ferrous chelate compound product.
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| CNA200810062256XA CN101606715A (en) | 2008-06-17 | 2008-06-17 | A kind of preparation method who disturbs anionic food-grade amino acid ferrous chelate compound that do not contain |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103224546A (en) * | 2013-05-06 | 2013-07-31 | 广州天科生物科技有限公司 | Hydration amino formyl glycine dipeptide chelating iron and preparation method thereof |
| CN106397234A (en) * | 2016-09-05 | 2017-02-15 | 河北东华冀衡化工有限公司 | Preparation method of interfering ion-free ferrous glycinate |
| CN107698455A (en) * | 2017-10-20 | 2018-02-16 | 衡阳德邦新金生物科技有限公司 | A kind of ferrous bisglycinate chelate and circulating mother liquor recovery process |
| CN108264546A (en) * | 2016-12-30 | 2018-07-10 | 河北凯盛医药科技有限公司 | Succinyl casein-ferrous iron and its preparation method and application |
| CN110003036A (en) * | 2019-04-24 | 2019-07-12 | 河北力维素科技有限公司 | A kind of amino acid-ferrous preparation method |
| CN110128307A (en) * | 2019-06-12 | 2019-08-16 | 禄丰天宝磷化工有限公司 | A kind of preparation method of stable amino acid-ferrous complex |
| CN110511155A (en) * | 2019-08-15 | 2019-11-29 | 河北力维素科技有限公司 | A kind of preparation method of asparatate mineral sequestration object and its salt |
| CN111777523A (en) * | 2020-06-08 | 2020-10-16 | 四川爱隆植物营养科技有限公司 | Preparation method of glycine iron chelate |
| CN113575967A (en) * | 2021-08-04 | 2021-11-02 | 吴善艳 | Formula reagent with iron supplementing function and preparation method thereof |
| CN115918885A (en) * | 2022-12-08 | 2023-04-07 | 益盐堂（应城）健康盐制盐有限公司 | Anti-caking edible salt and preparation method thereof |
-
2008
- 2008-06-17 CN CNA200810062256XA patent/CN101606715A/en active Pending
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103224546A (en) * | 2013-05-06 | 2013-07-31 | 广州天科生物科技有限公司 | Hydration amino formyl glycine dipeptide chelating iron and preparation method thereof |
| CN106397234A (en) * | 2016-09-05 | 2017-02-15 | 河北东华冀衡化工有限公司 | Preparation method of interfering ion-free ferrous glycinate |
| CN108264546A (en) * | 2016-12-30 | 2018-07-10 | 河北凯盛医药科技有限公司 | Succinyl casein-ferrous iron and its preparation method and application |
| CN107698455A (en) * | 2017-10-20 | 2018-02-16 | 衡阳德邦新金生物科技有限公司 | A kind of ferrous bisglycinate chelate and circulating mother liquor recovery process |
| CN110003036A (en) * | 2019-04-24 | 2019-07-12 | 河北力维素科技有限公司 | A kind of amino acid-ferrous preparation method |
| CN110128307A (en) * | 2019-06-12 | 2019-08-16 | 禄丰天宝磷化工有限公司 | A kind of preparation method of stable amino acid-ferrous complex |
| CN110128307B (en) * | 2019-06-12 | 2021-06-29 | 天宝动物营养科技股份有限公司 | Preparation method of stable ferrous amino acid complex |
| CN110511155A (en) * | 2019-08-15 | 2019-11-29 | 河北力维素科技有限公司 | A kind of preparation method of asparatate mineral sequestration object and its salt |
| CN111777523A (en) * | 2020-06-08 | 2020-10-16 | 四川爱隆植物营养科技有限公司 | Preparation method of glycine iron chelate |
| CN113575967A (en) * | 2021-08-04 | 2021-11-02 | 吴善艳 | Formula reagent with iron supplementing function and preparation method thereof |
| CN115918885A (en) * | 2022-12-08 | 2023-04-07 | 益盐堂（应城）健康盐制盐有限公司 | Anti-caking edible salt and preparation method thereof |
| CN115918885B (en) * | 2022-12-08 | 2024-02-27 | 益盐堂（应城）健康盐制盐有限公司 | Anti-caking edible salt and preparation method thereof |
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Open date: 20091223 |