CN101601970B - Filter and pipeline system used for cerebrospinal fluid purification device - Google Patents

Filter and pipeline system used for cerebrospinal fluid purification device Download PDF

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Publication number
CN101601970B
CN101601970B CN200910000344.1A CN200910000344A CN101601970B CN 101601970 B CN101601970 B CN 101601970B CN 200910000344 A CN200910000344 A CN 200910000344A CN 101601970 B CN101601970 B CN 101601970B
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filter
cerebrospinal fluid
purification
kettle
exhaust
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CN200910000344.1A
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CN101601970A (en
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王拥军
张星虎
王缨
吴志敏
程庆伟
叶文渊
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D63/00Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02Hollow fibre modules
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D71/00Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06Organic material
    • B01D71/66Polymers having sulfur in the main chain, with or without nitrogen, oxygen or carbon only
    • B01D71/68Polysulfones; Polyethersulfones

Abstract

The invention discloses a filter and a corresponding pipeline system used for a cerebrospinal fluid purification device. The filter comprises a casing and filter cores and adopts a three-cavity three-opening structure type, and the filter cores are hollow fibrous membranes and are in a parallel arrangement structure. In the invention, cerebrospinal fluid with pathogenic bacteria and blood cells flows in a membrane internal cavity at the time of purification operation, the purified cerebrospinal fluid is filtered out from a membrane side hole, the invention effectively filters and removes the pathogenic bacteria and the blood cells in the cerebrospinal fluid and also has the function of self cleaning, the blockage of a filter membrane is unlikely to occur, the filter area in a smaller cavity body is increased, the volume of the cerebrospinal fluid filter reaches minimum, and the clinical use requirement is met. Corresponding to the filter, a corresponding disposable pipeline system is also provided, the entire filter and the entire pipeline system are made into whole sealing connection and are matched with the existing device for disposable use, medical source type infection which can be caused by connection operation does not exist, and the clinical problems of purification, extraction and back importation of the cerebrospinal fluid can be effectively solved.

Description

The filter and the pipe-line system that are used for cerebrospinal fluid purification device
Technical field
The present invention relates to a kind of cerebrospinal fluid external drainage displacement purge therapeutic system, relate in particular to a kind of filter that is used for cerebrospinal fluid purification device and reach, be applied to clinical monitoring treatment encephalic illness patient by its pipe-line system of forming.
Background technology
Cerebrospinal fluid cerebral spinal fluid (CSF) is the colourless transparent liquid that riddles in ventricular system, myelocoele and the subarachnoid space; Include inorganic ions, glucose and a small amount of albumen; Cell seldom; Be mainly monocyte and lymphocyte, its function is equivalent to the lymph liquid in the peripheral tissues, and central nervous system is played buffering, protection, nutrition, transportation metabolite and keeps normal intracranial pressure.In clinical; Because hematocele, myelencephalon inflammation or the like in brain trauma cerebral hemorrhage, headstroke cerebral hemorrhage, cerebral aneurysm cerebral hemorrhage, cerebrovascular malformation cerebral hemorrhage, the brain operation brain; Make the cerebrospinal fluid in the brain become muddy courage and uprightness or inflammatory cerebrospinal fluid, can cause the patient to produce serious clinical symptoms even life danger clinically.
Autocerebrospinal purification is a difficult problem that perplexs the clinical treatment treatment means for many years, and is main because the total amount of human body cerebrospinal fluid is merely 70-160ml, is the great fluctuation process of crossing of avoiding intracranial pressure when clinical extraction and feedback; Once draw and the feedback amount is merely 10-20ml, and the time of drawing and feeding back is slow relatively, it is more little good more therefore to require the minimum of therapy system pipeline to deposit capacity; Traditional filter is the monofilm structure; Two chambeies, two shape of the mouth as one speaks formulas as shown in Figure 1 mainly constitute two chambers by shell 103 and inner filter membrane 104, and cerebrospinal fluid is got into by arrival end 102; After filter membrane 104 filters; Flow out by the port of export 101 after removing wherein germ, haemocyte, do not influence filtration, need do the filter membrane area very greatly for guaranteeing that the filter membrane mesh can progressively not blocked; This just causes filter volume and structure bigger, is not suitable for the clinical requirement that cerebrospinal fluid filters.
In addition; Still there is not a kind of disposable pipeline that is used for cerebrospinal fluid displacement, purification in clinical; Like Chinese patent 200520110390.4 disclosed cerebrospinal fluid purification devices, be the purification treatment operation of temporarily building the cerebrospinal fluid that pipe-line system realizes instrument in the existing operation, use general pipeline, joint, filter to form temporary system; Doctor's workload is big in connecting line and operating process, and the contaminated chance of interface increases.
Summary of the invention
The purpose of this invention is to provide a kind of new filter that cerebrospinal fluid filters that is used for; Have little volume, can self-cleaning, be difficult for taking place filter membrane and stop up; A kind of pipe-line system of using this filter also is provided simultaneously; Whole filter and pipe-line system are made totally-enclosed connection, and disposable use does not exist owing to be operatively connected and issuable hospital-acquired infection.
The objective of the invention is to realize through following technical scheme:
A kind of filter that is used for cerebrospinal fluid purification device comprises shell and filter core, it is characterized in that structural shape is three mouthfuls in three chambeies, and said filter core is a hollow-fibre membrane, is the structure that is arranged in parallel.
Said sheathing material is a Merlon, and said hollow-fibre membrane is the polyether sulfone hollow-fibre membrane, and its hole is 80A ° to 100A °; Adopt polyurethane glue to be enclosed in admittedly in the shell, form the structural shape in three mouthfuls in three chambeies, during purification run; Cerebrospinal fluid after the cerebrospinal fluid of disease carrying germ, haemocyte flows in the film inner chamber, purifies leaches from the film side opening, has the self-cleaning function in germ in effective filtering cerebrospinal fluid and the haemocyte, is difficult for taking place filter membrane and stops up; Filter membrane is made up of the hollow-fibre membrane of multiply parallel connection dense arrangement; Thereby in littler cavity, increased filter area, made the volume of cerebrospinal fluid filter reach minimum, satisfied clinical instructions for use.
A kind of one-shot tube road system that is used for cerebrospinal fluid purification device that uses this filter also is provided in addition; Each parts of pipeline are made of one with filter; Satisfy clinical disposable use, do not need interim assembling, can effectively avoid being operatively connected and issuable hospital-acquired infection.The characteristics of this pipe-line system are:
The cerebrospinal purification of filter 2 outlet 24 is in order through feeding back pump line 51, exhaust kettle 41 backs through three-way pipe and tube connector 6 with draw pump line 52 and join;
The cerebrospinal fluid of filter 2 is drawn import 25 and is joined through three-way pipe 33 and exhaust kettle 42 and buffer solution bag 9;
The cerebrospinal fluid of filter 2 draw outlet 26 through three-way pipe 32 and fairlead 6 with draw pump line 52 and join, also join through three-way pipe 34 and discarded liquid bag 8.
Further, for making things convenient for detector tube intracranial pressure and loine pressure state, said exhaust kettle 41, exhaust kettle 42 all are connected to the cone joint 7 that can be connected usefulness with the sensor protection cover.
Said feedback pump line 51, draw pump line 52 and be silica gel hose, can be used with occlusion pump.
Said three-way pipe and connection all adopt the medical PVC plastics to process with pipeline, guarantee safe in utilization.
For making things convenient for the use of pipe-line system, said tube connector 6 front ends are equipped with band wing cone joint 17 and can join with lumbar puncture needle.
Description of drawings
According to accompanying drawing and embodiment the present invention is done further explain below.
Fig. 1 is traditional cerebrospinal fluid filter structure schematic representation;
Fig. 2 is the structural representation that is used for the filter of cerebrospinal fluid purification device of the present invention;
Fig. 3 is an one-shot tube of the present invention road system diagram.
Among the figure:
101, the port of export; 102, arrival end; 103, shell; 104, filter membrane.
21, shell; 22, polyurethane glue; 23, filter core; 24, cerebrospinal purification outlet; 25, cerebrospinal fluid is drawn import; 26, cerebrospinal fluid is drawn outlet.
2, filter; 31,32,33,34, three-way pipe; 41,42, exhaust kettle; 51, feed back pump line; 52, draw pump line; 6, tube connector; 7, cone joint; 8, discarded liquid bag; 9, buffer solution bag; 10, band wing female cone joint; 11,12,13,14,15, electronic pipe clamp; 16, manual pipe clamp; 17, band wing cone joint.
The specific embodiment
As shown in Figure 2, the filter that is used for cerebrospinal fluid purification device of the present invention comprises the shell 21 and filter core 23 of Merlon; Filter core 23 can adopt the polyether sulfone hollow-fibre membrane, is arranged in parallel about 2000, and its membrane pores is 80A ° to 100A °; Two ends employing polyurethane glue 22 is fixed and is sealed, and structural shape is three mouthfuls in three chambeies, and three mouthfuls are respectively cerebrospinal purification outlet 24; Cerebrospinal fluid is drawn import 25, and cerebrospinal fluid is drawn outlet 26; Form three chambeies respectively at these three opening parts; During use, cerebrospinal fluid is drawn import 25 by cerebrospinal fluid and is got into the import cavity, distributes to filter core 23; And draw outlet 26 by cerebrospinal fluid and flow out; Carry out side in cerebrospinal purification outlet 24 simultaneously and take out, germ and haemocyte in the cerebrospinal fluid are stopped by hollow-fibre membrane, can feed back after the cerebrospinal fluid of purification is drawn out of; The cerebrospinal fluid that germ that is stopped by hollow-fibre membrane and haemocyte flow in again can tunicle is taken away, and can not block the hole of filter core 23 and influences clean-up effect.Filter core 23 is made up of the hollow-fibre membrane of multiply parallel connection dense arrangement, thereby in littler cavity, has increased filter area, makes the volume of cerebrospinal fluid filter reach minimum, satisfies clinical instructions for use.
Fig. 3 has provided a kind of disposable pipe-line system of using aforementioned filter; Each parts of pipeline are made of one with pipeline; Satisfy clinical disposable use; Can cooperate patent 200520110390.4 disclosed cerebrospinal fluid purification devices to use, can effectively avoid being operatively connected and issuable hospital-acquired infection, reduce workload.Its concrete implementation is:
The cerebrospinal purification of filter 2 outlet 24 is in order through feeding back pump line 51, exhaust kettle 41 backs through three-way pipe and tube connector 6 with draw pump line 52 and join; The cerebrospinal fluid of filter 2 is drawn import 25 and is joined through three-way pipe 33 and exhaust kettle 42 and buffer solution bag 9, have before the buffer solution bag 9 one have a wing female cone joint 10 branch road, control with manual pipe clamp 16 and can conveniently discharge liquid; The cerebrospinal fluid of filter 2 draw outlet 26 through three-way pipe 32 and tube connector 6 with draw pump line 52 and join, also join through three-way pipe 34 and discarded liquid bag 8.For making things convenient for detector tube intracranial pressure and loine pressure state, said exhaust kettle 41, exhaust kettle 42 all are connected to the cone joint 7 that can be connected usefulness with the sensor protection cover.Feed back pump line 51, draw pump line 52, can be used with occlusion pump for silica gel hose.Three-way pipe and connect and all to adopt the medical PVC plastics to process with pipeline is guaranteed safe in utilizationly, and for making things convenient for the use of pipe-line system, said tube connector 6 front ends are equipped with band wing cone joint 17 and can join with patient's lumbar puncture needle.
When cooperating patent 200520110390.4 disclosed cerebrospinal fluid purification devices to use; As shown in Figure 3; To draw pump line 52, feed back pump line 51 and be installed in respectively and draw pump and feed back on the pump; Pipeline position shown in corresponding electronic pipe clamp 11,12,13,14,15 is contained in respectively on the instrument, waste fluid bag 8 is hung on the electronic scale with buffer solution bag 9, can realize following process through programme-control:
1, pipeline preliminary filling
At first the band wing cone joint of tube connector 6 17 is connected with the container that physiological saline or artificial cerebrospinal fluid are housed and carries out the pipeline preliminary filling, open the manual pipe clamp 16 of waste fluid bag 8 exits, click " pipeline preliminary filling " key, begin the pipeline preliminary filling by system prompt.Preliminary filling is in proper order:
A) preliminary filling exhaust kettle 42 system modes are: the pump of drawing of drawing pump line 52 places begins to rotate, and electronic pipe clamp 11 is opened, and all the other electronic pipe clamps are closed.At this moment, the manual pipe clamp 16 of exhaust kettle 42 upper end blast pipes is shown in an open position, treat that exhaust kettle 42 is full of liquid after, close manual pipe clamp 16, press system prompt, carry out next step operation, beginning preliminary filling bumping bag 9.
B) preliminary filling bumping bag system mode is: electronic pipe clamp 11,15 is opened, and all the other electronic pipe clamps are closed.Electronic pipe clamp 15 was closed after priming fluid got into bumping bag and reaches set amount, drew pump and stopped automatically, and the priming fluid in this moment buffer solution bag 9 is closed manual pipe clamp 16 on it after through the emptying of inlet branch road, carries out next step operation, the preliminary filling circulation line.
C) preliminary filling circulating pipe system state is: electronic pipe clamp 11,14 is opened, and all the other electronic pipe clamps are closed.After priming fluid entering waste fluid bag 8 reaches ormal weight, carry out next step operation, the preliminary filling recirculation line.
D) preliminary filling recirculation line system mode is: the feedback pump that feeds back pump line 51 places begins to rotate, and electronic pipe clamp 11,12,14 is opened, and all the other electronic pipe clamps are closed.Manual unlocking pipeline exhaust this moment kettle 41 upper end blast pipe pipe clamps 16, treat that the exhaust kettle is full of liquid after, close manual pipe clamp 16; Carry out next step operation, the purging system pipeline.
E) purging system pipeline, system mode are that electronic pipe clamp 11,12,13,14 is opened, and electronic pipe clamp 15 is closed.After treating that waste fluid bag 8 reaches the capacity of setting, preliminary filling finishes.This moment, the exhaust outlet with exhaust kettle 41,42 was connected on the sensor protection shield joint of connecting with " intracranial pressure ", " pressing behind the pump " two pressure monitoring points (cut-in pressure sensor) through cone joint 7 respectively; Open the manual pipe clamp 16 that links to each other with exhaust kettle 41,42 simultaneously, folder closes the manual pipe clamp 16 of waste fluid bag exit.
2, cerebrospinal fluid is drawn
The band wing cone joint 17 of fairlead 6 is connected patient's lumbar puncture needle; This moment, electronic pipe clamp 11,15 was opened; Other electronic pipe clamps are closed; Draw pump and with set point speed extruding pump line 52 cerebrospinal fluid is led in the buffer solution bag 9, after the amount of drawing reached setting value, system got into the feedback stage automatically under programme-control.
3, cerebrospinal fluid feeds back
Electronic pipe clamp 12,13,14,15 is opened; Electronic pipe clamp 11 is closed; Feed back pump and from buffer solution bag 9, extract cerebrospinal fluid out purification and feedback with setting value flow velocity extruding pump line 51; Draw pump simultaneously with the work of system default value flow velocity, the cerebrospinal fluid that does not purify is flowed, in filter 2 inner chamber Rapid Cycle up to meeting the requirements of the feedback amount.
Be used the pipe-line system of filter of the present invention and composition; Can accomplish preliminary filling; And draw and feed back constantly hocketing of process to set little cubical content through above-mentioned cerebrospinal fluid, and can effectively advance patient's cerebrospinal fluid is carried out corresponding purified treatment, process operation is easy; Do not need to assemble pipeline temporarily, effectively improve the reliability of operation.

Claims (7)

1. one-shot tube road device that is used for cerebrospinal fluid purification device; It is characterized in that including the filter (2) that is used for cerebrospinal fluid purification device; This filter comprises shell and filter core; The structural shape that it is characterized in that this filter is three mouthfuls in three chambeies, and three mouthfuls are respectively that import is drawn in cerebrospinal purification outlet, cerebrospinal fluid, cerebrospinal fluid is drawn outlet, forms three chambeies respectively at these three opening parts;
Said filter core is a hollow-fibre membrane, is the structure that is arranged in parallel;
Each parts of pipeline are made of one with pipeline;
The cerebrospinal purification of filter (2) outlet (24) is in order through feeding back pump line (51), the first exhaust kettle (41) back through first three-way pipe (31) and fairlead (6) with draw pump line (52) and join;
The cerebrospinal fluid of filter (2) is drawn import (25) and is joined through second three-way pipe (33) and the second exhaust kettle (42) and buffer solution bag (9);
The cerebrospinal fluid of filter (2) draw outlet (26) through the 3rd three-way pipe (32) and fairlead (6) with draw pump line (52) and join, also join through the 4th three-way pipe (34) and discarded liquid bag (8).
2. device according to claim 1; It is characterized in that; Said hollow-fibre membrane is the polyether sulfone hollow-fibre membrane, and its hole is that
Figure FSB00000765413100011
is to
Figure FSB00000765413100012
3. device according to claim 1 is characterized in that, the material of said shell is a Merlon.
4. device according to claim 1 is characterized in that the said first exhaust kettle (41), the second exhaust kettle (42) all are connected to the cone joint (7) that can be connected usefulness with the sensor protection cover.
5. device according to claim 1, it is characterized in that said feedback pump line (51), drawing pump line (52) is silica gel hose.
6. device according to claim 1 is characterized in that each three-way pipe and connects all adopting the medical PVC plastics to process with pipeline.
7. according to described any device of claim 1 to 6, it is characterized in that said fairlead (6) front end is equipped with the band wing cone joint (17) that can join with lumbar puncture needle.
CN200910000344.1A 2009-01-06 2009-01-06 Filter and pipeline system used for cerebrospinal fluid purification device Expired - Fee Related CN101601970B (en)

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CN200910000344.1A CN101601970B (en) 2009-01-06 2009-01-06 Filter and pipeline system used for cerebrospinal fluid purification device

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CN101601970B true CN101601970B (en) 2012-06-27

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110575573B (en) * 2019-09-24 2020-12-22 福建医科大学附属第一医院 Disposable pipeline installation system for continuous purification treatment of artificial cerebrospinal fluid

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5017293A (en) * 1989-08-24 1991-05-21 Pfizer Hospital Products Group, Inc. Multi-pass blood washing and plasma removal device and method

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5017293A (en) * 1989-08-24 1991-05-21 Pfizer Hospital Products Group, Inc. Multi-pass blood washing and plasma removal device and method

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