CN101596341A - A kind of ultra-low frequency transcranial magnetic stimulation device and preparation method thereof - Google Patents

Abstract

The invention discloses a kind of ultra-low frequency transcranial magnetic stimulation device, this device comprises the hollow coil that is superimposed more than or, described hollow coil is formed by the lead coiling, and the hollow space of hollow coil can hold human or animal's part or all of head; The internal diameter of described hollow coil is 30-500mm, and resistance is 1-30 ohm, and wire diameter is 0.1-5mm.Correspondingly, the invention also discloses the method for preparing ultra-low frequency transcranial magnetic stimulation device.Ultra-low frequency transcranial magnetic stimulation device of the present invention, be used to make the intrasonic electric current to produce the intrasonic time-varying magnetic field, the stimulation magnetic field that it produced can cover the brain universe, and can produce the magnetic field of sufficient intensity in the brain universe, the intensity in hub of a spool Dian Chu magnetic field can reach 800 Gausses, can guarantee curative effect.

Description

A kind of ultra-low frequency transcranial magnetic stimulation device and preparation method thereof

Technical field

The present invention relates to the transcranial magnetic stimulation technical field, relate in particular to a kind of ultra-low frequency transcranial magnetic stimulation device and preparation method thereof.

Background technology

Transcranial magnetic stimulation (Transcranial Magnetic Stimulation, TMS) be that a kind of the action of a magnetic field that utilizes is in central nervous system (mainly being brain), produce faradic current and the cell that excites nerve generation action potential at brain, thereby cause that a series of plysiochemical reaction influences the technology of brain function.Transcranial magnetic stimulation technology (TMS) is as a kind of important method that is used for the treatment of central nervous system disease, it has the benefit that obviously is better than electricity irritation, reason is electricity irritation meeting decay rapidly in being transmitted to by the stimulation location process, and employing transcranial magnetic stimulation technology (TMS), the magnetic signal lowland of can decaying hardly sees through skull and stimulates cerebral cortex, and transcranial magnetic stimulation technology (TMS) is not limited to stimulation to brain in actual applications, and the magnetic that peripheral nervous muscle equally also can be accepted transcranial magnetic stimulation technology (TMS) stimulates.

At present, (Transcranial Magnetic Stimulation, TMS) product mainly is that pulsed magnetic stimulates to the transcranial magnetic stimulation of prior art, has pulse magnetic stimulator, dipulse magnetic stimulator and continuous impulse to stimulate instrument three classes.It all has very widely in the treatment field of nerve research diagnostic field and central nervous system disease uses, but curative effect has more dispute.

Existing transcranial magnetic stimulation instrument adopts pulse current produce to stimulate more and since the frequency of pulse current be at random, high frequency, the magnetic field of generation also is high frequency, the space penetration power is strong.Therefore, existing transcranial magnetic stimulation instrument adopts the circular coil of one or more horizontal layout usually, and the side that during use is coil is facing to the position that needs to stimulate.Because the magnetic stimulating coil side is facing to brain, if when the frequency in magnetic field is very low, because very serious space attenuation is arranged, the magnetic field intensity that arrives brain can be very low, has a strong impact on therapeutic effect.

Chinese patent CN200520109760 discloses a kind of central nervous system's magnetic stimulating device, though this device can realize that the brain universe is carried out magnetic to stimulate, but the transcranial magnetic stimulation coil that it adopts is aimed at the pulse current design, because coil radius is too small, coil can not produce enough big thorn exciting field, if the coil in will inventing, be used for by the intrasonic electric current generation intrasonic time-varying magnetic field of frequency less than 0.2Hz, the characteristic of the space attenuation in the ULF magnetic field that produce this moment is obvious, the magnetic that coil can't satisfy the brain universe at all stimulates requirement, has a strong impact on therapeutic effect.

Summary of the invention

In view of this, technical problem solved by the invention is, a kind of ultra-low frequency transcranial magnetic stimulation device is provided, adopt hollow structure, preferred apery brain hemispherical hollow design, during treatment, human or animal's head is positioned over the coil hollow space, can guarantee under the prerequisite that magnetic field intensity requires that the brain universe is carried out magnetic to stimulate.

Technical problem solved by the invention also is, a kind of ultra-low frequency transcranial magnetic stimulation device is provided, and can guarantee under the prerequisite that magnetic field intensity requires, and is applicable in the transcranial magnetic stimulation instrument that adopts the intrasonic electric current to produce the intrasonic time-varying magnetic field.

In order to solve above technical problem, embodiments of the invention provide a kind of ultra-low frequency transcranial magnetic stimulation device, comprise the hollow coil that is superimposed more than or, described hollow coil is formed by the lead coiling, and the hollow space of hollow coil can hold human or animal's part or all of head; The internal diameter of described hollow coil is 30-500mm, and resistance is 1-30 ohm, and wire diameter is 0.1-5mm.

Because ultra-low frequency transcranial magnetic stimulation of the present invention adopts the design of apery brain hemispherical with coil, coil is wrapped on the hemispherical coil rack of apery brain, the thorn exciting field that is produced covers the brain universe, can the effective stimulus cerebral deep, make the brain top layer accept effective strong stimulation, be applicable in the transcranial magnetic stimulation instrument that adopts the intrasonic electric current to produce the intrasonic time-varying magnetic field.

As to improvement of the technical scheme, a kind of ultra-low frequency transcranial magnetic stimulation device that the embodiment of the invention provides further comprises some or all of in the following technical characterictic:

Wherein, described hollow coil superposes near the axis of hollow coil or axis.

Preferably, this ultra-low frequency transcranial magnetic stimulation device also disposes coil rack with the support as the hollow coil, is installed on correspondingly in the medical apparatus and instruments so that it can be effective and reasonable.

Further preferably, described coil rack is set to hollow structure, and this hollow structure is used for placing human or animal's head when treatment; With described hollow coil accordingly, the hollow structure that is provided with on the described coil rack also adopts anti-human brain hemisphere design.Described lead goes in ring and is wound in described coil rack.

Preferably, in order to twine described coil effectively, easily, described coil rack arranged outside has at least one coil groove;

Described coil groove is an axle with the axis of described coil rack, around being arranged on the described coil rack;

Described lead is wound in the described coil groove.

Preferably, described coil groove is set to a plurality of, and described lead is wound in respectively in the described coil groove, and separates by the groove edge between the coil groove.More preferably, described coil groove is set to four.

Further, according to the needs of treatment, required magnetic stimulates magnetic field intensity and distribution can make correspondingly adjustment, and therefore the internal diameter of described coil groove can be adjusted as the case may be.

In order to reach good curative effect and convenient the use, described coil rack is set to the hemispherical hollow housing or the cylindrical hollow housing of apery brain.

Further, in order to reduce the magnetic field intensity loss, the coil rack that ultra-low frequency transcranial magnetic stimulation device of the present invention adopts uses the magnetic field low-loss material to process.

Correspondingly, the invention also discloses a kind of method for preparing ultra-low frequency transcranial magnetic stimulation device, it comprises the steps:

(1) according to " Biot's one Sa cuts down Er Dinglv ", for satisfying desired magnetic field intensity, adopt the finite element simulation analytical method, can draw the parameter of coil, these parameters comprise the internal diameter of coil, thickness, highly, the number of turn, resistance, and the line of enamel-covered wire footpath.Go out to satisfy the transcranial magnetic stimulation coil that different treatments require according to parameter designing then, perhaps can change the intensity and the distribution of thorn exciting field, to satisfy different treatment requirements by adjusting coil parameter.

(2) when concrete coiling, can calculate the weight of required lead according to resistance, the line footpath of lead, the proportion of lead; Weight with control coil during coiling replaces the control number of turn, makes more convenient like this.

(3) need be in a plurality of coil grooves during coiling, can earlier the lead coiling of whole coil grooves be finished, whole again dipping lacquer is fixed.

According to above-mentioned preparation method, for the thorn exciting field that ultra-low frequency transcranial magnetic stimulation device of the present invention is produced reaches requirement of strength, according to " Biot Savart law "

$B=\frac{{\mathrm{\μ}}_0}{4\mathrm{\π}}\∫\frac{\mathrm{Idl}\×\stackrel{\→}{r}}{r^2}$

As can be seen, for satisfying desired magnetic field intensity B, adopt the finite element simulation analytical method from formula, can draw the parameter of coil, these parameters comprise the internal diameter of coil, thickness, highly, the number of turn, resistance, and the line of enamel-covered wire footpath.Go out to satisfy the transcranial magnetic stimulation coil that different treatments require according to parameter designing then, perhaps can change the intensity and the distribution of thorn exciting field, to satisfy different treatment requirements by adjusting coil parameter.

A kind of transcranial magnetic stimulation coil that adopts embodiments of the invention to provide has following beneficial effect at least:

Because transcranial magnetic stimulation of the present invention adopts the design of apery brain hemispherical with coil, coil is wrapped on the hemispherical coil rack of apery brain, the thorn exciting field that produced covers the brain universe, can the effective stimulus cerebral deep, or make the brain top layer accept effective strong stimulation; Be applicable in the transcranial magnetic stimulation instrument that adopts the intrasonic electric current to produce the intrasonic time-varying magnetic field.

Ultra-low frequency transcranial magnetic stimulation device of the present invention can be used to make the intrasonic electric current to produce the intrasonic time-varying magnetic field, and can produce the magnetic field of sufficient intensity in the brain universe, and the intensity in hub of a spool Dian Chu magnetic field can reach 800 Gausses, can guarantee curative effect.

Description of drawings

Fig. 1 is the structure chart of a kind of ultra-low frequency transcranial magnetic stimulation device of providing of the embodiment of the invention one;

Fig. 2 is the structure chart of a kind of ultra-low frequency transcranial magnetic stimulation device of providing of the embodiment of the invention two;

Fig. 3 is the magnetic field distribution figure of a kind of ultra-low frequency transcranial magnetic stimulation device of providing of the embodiment of the invention two;

Fig. 4 is the magnetic induction line scattergram of a kind of ultra-low frequency transcranial magnetic stimulation device of providing of the embodiment of the invention two.

The specific embodiment

In order to make technical problem to be solved by this invention, technical scheme and beneficial effect clearer,, the present invention is further elaborated below in conjunction with drawings and Examples.Should be pointed out that specific embodiment described herein only in order to explanation the present invention, and be not used in qualification the present invention.

As shown in Figure 1, a kind of ultra-low frequency transcranial magnetic stimulation device that the embodiment of the invention one provides, comprise hollow coil 12 and as the coil rack 11 of hollow coil support, hollow coil 12 is formed by the lead coiling, the hollow space of hollow coil 12 can hold human or animal's part or all of head, coil rack 11 is set to the hemispherical hollow housing of apery brain, and lead 12 goes in ring and is wound in hemisphere hollow shape housing.

In the embodiment of the invention one, coil rack is provided with a coil groove 111, and coil groove 111 both sides are provided with groove edge 115.During specific implementation, coil groove 111 is an axle with the axis of hemispherical shell, and around being arranged on the hemispherical shell, lead is wound in the coil groove 111.In the present embodiment, in the online ring recess 111 of lead uniform winding, the stimulation Distribution of Magnetic Field that coil is produced is even, improves the curative effect that magnetic stimulates.Groove edge 115 can be limited in coil 12 fixed winding scope, prevents that coil from coming off and phenomenon such as skew.Certainly in other embodiments, coil groove and the hollow coil that wherein is provided with also can the axis of hemispherical shell near the position be spool, around being arranged on the hemispherical shell.

The centre zone at hemispherical shell top is provided with opening 1, is provided with a boss around the opening 1, forms a coil official hats and canopies 114; Coil official hats and canopies 114 is provided with screw 114, and screw 114 is used for fixing coil rack 11, perhaps ancillary equipment is fixed on the coil rack 11.The centre zone of hemispherical shell bottom is provided with opening 2 113, coil groove 111 is on the capable coil rack 11 that is arranged between opening 1 and the opening 2 113 of the axle collar with the axis of hemispherical shell, and based on this, coil 12 also is wrapped on the coil rack 11 between opening 1 and the opening 2 113, not only can make the internal diameter of coil enough big by this canoe, can allow the head of larger volume to enter, and make the magnetic field of generation can cover the brain universe to realize good magnetic effect of stimulation.

Adopt the transcranial magnetic stimulation coil of the embodiment of the invention one, hollow coil 12 is wrapped on the hemispherical coil rack 11 of apery brain, the thorn exciting field that produced covers the brain universe, can the effective stimulus cerebral deep, or make the brain top layer accept effective strong stimulation; And can enough big radius be arranged hollow coil 12, be applicable in the transcranial magnetic stimulation instrument that adopts the intrasonic electric current to produce the intrasonic time-varying magnetic field.

As shown in Figure 2, as a kind of optimal technical scheme to the embodiment of the invention one, a kind of ultra-low frequency transcranial magnetic stimulation device that the embodiment of the invention two provides, hollow coil 22 and as the coil rack 21 of hollow coil support, hollow coil 22 is formed by the lead coiling, the hollow space of hollow coil 22 can hold human or animal's part or all of head, and coil rack 21 is set to the hemispherical hollow housing of apery brain, and lead 22 goes in ring and is wound in hemisphere hollow shape housing.

Different with embodiment one is, among the embodiment, coil rack is provided with four coil grooves 211, and lead 22 is wound in respectively in the coil groove 211, and separates by the groove edge 215 between the coil groove.During specific implementation, coil groove 211 is an axle with the axis of hemispherical shell, around being arranged on the hemispherical shell, lead is wound in the coil groove 211, and the interval between the groove edge 215 is identical, in identical at interval coil groove 211, can make transcranial magnetic stimulation even the lead uniform winding, improve the curative effect that magnetic stimulates with the stimulation Distribution of Magnetic Field that device produces.In addition, lead is wound in respectively in the coil groove 211, can be by adjusting the coil parameter in each groove respectively, and adjusting stimulates DISTRIBUTION OF MAGNETIC FIELD and intensity, uses and designs all very conveniently, and can satisfy different treatment requirements.

The centre zone at hemispherical shell top is provided with opening 1, is provided with a boss around the opening 1, forms a coil official hats and canopies 214; Coil official hats and canopies 114 is provided with screw 214, and screw 214 is used for fixing coil rack 21, perhaps ancillary equipment is fixed on the coil rack 21.The centre zone of hemispherical shell bottom is provided with opening 2 213, coil groove 211 is on the capable coil rack 21 that is arranged between opening 1 and the opening 2 213 of the axle collar with the axis of hemispherical shell, in the present embodiment, because the interval between the groove edge 215 is identical, four coil grooves 211 are evenly distributed on the coil rack 21 between opening 1 and the opening 2 213.

In addition, in order further to reduce the loss of the magnetic thorn exciting field that coil produced, the transcranial magnetic stimulation coil that provides among the embodiment of the invention one and the embodiment two, its coil rack that adopts use the magnetic field low-loss material to process.

As shown in Figure 3, when the transcranial magnetic stimulation with embodiment two is used for the ultra low frequency magnetic stimulation system with coil, among Fig. 3, four stimulating coils of 31 expressions, 32 expression magnetic stimulated zone, in therapeutic process, brain places the magnetic stimulated zone.By it can also be seen that the DISTRIBUTION OF MAGNETIC FIELD situation among the figure, 35 is high magnetic field area, 33 is the low-intensity magnetic field zone, 34 is the marginal moderate high magnetic field area of magnetic field intensity, magnetic stimulated zone 32 is in high-intensity magnetic field and moderate high magnetic field area 34 scopes substantially, brain receiving coil magnetic in this zone stimulates, and therapeutic effect is good.

As shown in Figure 4,4 stimulating coils of 41 expressions, 42 expression magnetic stimulated zone, in therapeutic process, brain places the magnetic stimulated zone, and as can be seen from the figure, the magnetic field intensity of magnetic stimulated zone 42 is more uniform, reaches designing requirement.

The ultra-low frequency transcranial magnetic stimulation device that provides among the embodiment of the invention one and the embodiment two, its design principle are based on all that " Biot Savart law " realize, suc as formula one:

Formula one:

$B=\frac{{\mathrm{\μ}}_0}{4\mathrm{\π}}\∫\frac{\mathrm{Idl}\×\stackrel{\→}{r}}{r^2}$

For the thorn exciting field that ultra-low frequency transcranial magnetic stimulation device of the present invention is produced reaches requirement of strength, under the condition of known magnetic field intensity B, adopt the finite element simulation analytical method, can draw the parameter of coil, these parameters comprise the internal diameter of hollow coil, thickness, highly, the number of turn, resistance, and the line of enamel-covered wire footpath.Go out to satisfy the transcranial magnetic stimulation coil that different treatments require according to parameter designing then, perhaps can change the intensity and the distribution of thorn exciting field, to satisfy different treatment requirements by adjusting coil parameter.

Illustrate that below in conjunction with embodiment the internal diameter of the coil of ultra-low frequency transcranial magnetic stimulation device of the present invention, resistance are, thickness, the adjustable range of wire diameter is with further announcement the present invention.

Embodiment three

When ultra-low frequency transcranial magnetic stimulation device only is provided with a coil, the lead uniform winding in the coil groove, in order to reach the magnetic field of designing requirement, can be according to the parameter designing coil in the table 1.

Table 1

The coil numbering	Internal diameter/mm	Thickness/mm	Wire diameter/mm	Resistance/ohm
					1	300	18	2	5

Certainly, according to " Biot Savart law ", the parameter in the last table also can be carried out suitable adjustment, is as the criterion to realize purpose of the present invention.

Embodiment four

When ultra-low frequency transcranial magnetic stimulation device only is provided with two coils, in each coil groove, the lead uniform winding, in order to reach the magnetic field of designing requirement, can be according to the parameter designing coil of table 2 to the table 4.

Table 2

The coil numbering	Internal diameter/mm	Thickness/mm	Wire diameter/mm	Resistance/ohm
					1	30	15	0.1	30
2	45	18	0.1	30

Table 3

The coil numbering	Internal diameter/mm	Thickness/mm	Wire diameter/mm	Resistance/ohm
					1	300	23	1.0	10
2	320	22	1.1	9.5

Table 4

The coil numbering	Internal diameter/mm	Thickness/mm	Wire diameter/mm	Resistance/ohm
					1	500	20	5	1
2	450	20	5	1

According to " Biot Savart law ", the parameter in above-mentioned each table also can be carried out suitable adjustment, is as the criterion to realize purpose of the present invention.

Embodiment five

When ultra-low frequency transcranial magnetic stimulation device only is provided with three coils, in each coil groove, the lead uniform winding, in order to reach the magnetic field of designing requirement, can be according to the parameter designing coil in the table 5.

Table 5

The coil numbering	Internal diameter/mm	Thickness/mm	Wire diameter/mm	Resistance/ohm
					1	400	18	3.5	3
2	380	19	3.5	3.2
					3	350	20	3.5	3.8

According to " Biot Savart law ", the parameter in above-mentioned each table also can be carried out suitable adjustment, is as the criterion to realize purpose of the present invention.

Embodiment six

When ultra-low frequency transcranial magnetic stimulation device only is provided with four coils, in each coil groove, the lead uniform winding, in order to reach the magnetic field of designing requirement, can be according to the parameter designing coil in the table 6.

Table 6

The coil numbering	Internal diameter/mm	Thickness/mm	Wire diameter/mm	Resistance/ohm
					1	250	25	1.0	6
2	260	25	1.0	6.2
					3	270	25	1.1	6.3
4	280	25	1.1	6.5

According to " Biot Savart law ", the parameter in above-mentioned each table also can be carried out suitable adjustment, is as the criterion to realize purpose of the present invention.

In above-mentioned each table:

Internal diameter is meant in this group coil winding scope, the meansigma methods of the internal diameter that is wound part of coil rack;

Thickness is exactly the width of coil groove herein;

Line directly is meant the line footpath of lead in the coil;

Resistance is meant the resistance of every group of coil.

The transcranial magnetic stimulation coil that adopts the coil parameter in above-mentioned each table to design can realize that the magnetic stimulus frequency of exporting is 0.001HZ～20HZ, and adjustable continuously now by 1 millihertz; Can reach maximum magnetic field strength in addition is 800 Gausses, and magnetic field intensity is adjustable continuously; The waveform of output is the stack of single sine wave or a plurality of sine waves.

The above is the specific embodiment of the present invention; certainly can not limit the present invention's interest field with this; should be understood that; for those skilled in the art; under the prerequisite that does not break away from the principle of the invention; can also make some improvement and change, these improvement and change also are considered as protection scope of the present invention.

Claims (10)

1, a kind of ultra-low frequency transcranial magnetic stimulation device, it is characterized in that: this device comprises the hollow coil that is superimposed more than or, described hollow coil is formed by the lead coiling, and the hollow space of hollow coil can hold human or animal's part or all of head; The internal diameter of described hollow coil is 30-500mm, and resistance is 1-30 ohm, and wire diameter is 0.1-5mm.

2, ultra-low frequency transcranial magnetic stimulation device according to claim 1 is characterized in that: described hollow coil superposes near the axis of hollow coil or axis.

3, ultra-low frequency transcranial magnetic stimulation device according to claim 1 is characterized in that: also dispose coil rack with the support as the hollow coil.

4, ultra-low frequency transcranial magnetic stimulation device according to claim 2 is characterized in that:

Described coil rack is set to hollow structure, and this hollow structure is used for placing human or animal's head when treatment;

Described lead goes in ring and is wound in described coil rack.

5, according to claim 2 or 3 described ultra-low frequency transcranial magnetic stimulation devices, it is characterized in that:

Described coil rack arranged outside has at least one coil groove;

Described coil groove is an axle with the axis of described coil rack, around being arranged on the described coil rack;

Described lead is wound in the described coil groove.

6, ultra-low frequency transcranial magnetic stimulation device according to claim 4 is characterized in that:

Described coil groove is set to a plurality of, and described lead is wound in respectively in the described coil groove, and separates by the groove edge between the coil groove.

7, ultra-low frequency transcranial magnetic stimulation device according to claim 4 is characterized in that: the internal diameter of described coil groove can be adjusted as the case may be.

8, ultra-low frequency transcranial magnetic stimulation device according to claim 2 is characterized in that: described coil rack is set to the hemispherical hollow housing or the cylindrical hollow housing of apery brain.

9, ultra-low frequency transcranial magnetic stimulation device according to claim 2 is characterized in that: its coil rack that adopts uses the magnetic field low-loss material to process.

10, a kind of method for preparing ultra-low frequency transcranial magnetic stimulation device as claimed in claim 1 comprises:

(1) according to " Biot Savart law ", for satisfying desired magnetic field intensity, adopt the finite element simulation analytical method, can draw the parameter of coil, these parameters comprise the internal diameter of coil, thickness, highly, the number of turn, resistance, and the line of enamel-covered wire footpath.Go out to satisfy the transcranial magnetic stimulation coil that different treatments require according to parameter designing then, perhaps can change the intensity and the distribution of thorn exciting field, to satisfy different treatment requirements by adjusting coil parameter.

(2) when concrete coiling, can calculate the weight of required lead according to resistance, the line footpath of lead, the proportion of lead; Weight with control coil during coiling replaces the control number of turn, makes more convenient like this.

(3) need be in a plurality of coil grooves during coiling, can earlier the lead coiling of whole coil grooves be finished, whole again dipping lacquer is fixed.

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