CN101591234A - A kind of method of producing magnesium citrate - Google Patents
A kind of method of producing magnesium citrate Download PDFInfo
- Publication number
- CN101591234A CN101591234A CNA2008100434039A CN200810043403A CN101591234A CN 101591234 A CN101591234 A CN 101591234A CN A2008100434039 A CNA2008100434039 A CN A2008100434039A CN 200810043403 A CN200810043403 A CN 200810043403A CN 101591234 A CN101591234 A CN 101591234A
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- China
- Prior art keywords
- magnesium
- magnesium citrate
- crystallization
- citrate
- magnesiumcarbonate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Abstract
The present invention relates to a kind of method of producing magnesium citrate, the characteristics of this method are that it utilizes magnesiumcarbonate or magnesium oxide or magnesium hydroxide to make magnesium citrate for the reaction of raw material and edible citric acid, obtain magnesium citrate after through overcooling, crystallization, with hot deionized water washing, drying, the finished product magnesium citrate of present method can be granular or Powdered, quality meets and exceeds the standard of American Pharmacopeia USP30/NF25, on specification, can control lead content＜0.000010% with the inventive method, according to the market requirement, sub-sieve gets granular and powder-product.
Description
Technical field
The present invention relates to a kind of method of producing magnesium citrate.
Background technology
At present, there is not the detail file introduction to produce the method for magnesium citrate at home as yet, more do not see disclosed patent is arranged, the magnesium citrate product is abroad as medicine and edible raw material, bring plumbous class heavy metal easily into when producing magnesium citrate at present, and general production method can not get crystallization or powdered magnesium citrate.
Summary of the invention
The present invention is directed to above production shortcoming, a kind of method of producing magnesium citrate is provided, it utilizes magnesiumcarbonate or magnesium oxide or magnesium hydroxide to make magnesium citrate for the reaction of raw material and edible citric acid, through overcooling, crystallization, with hot deionized water washing, obtain magnesium citrate after the drying, the technical characterictic that the present invention produces the processing method of magnesium citrate is: add dilute acetic acid solution again after magnesiumcarbonate or magnesium oxide or magnesium hydroxide are raw material and edible citric acid reaction, the content that control is plumbous, it is embodied as: a adds dissolving and filtration in the entry with citric acid, when temperature after heating reaches 70 ℃, begin magnesiumcarbonate or magnesium oxide or magnesium hydroxide are added gradually, its weight ratio is 0.55/0.29/0.41: 1, and the reaction soln pH value is between 5-8; B adds dilute acetic acid solution, the content that control is plumbous; C requires to carry out sub-sieve according to granularity after overcooling, crystallization, washing, drying, makes finished lemon acid magnesium crystallization or pulvis, make particle as need, available 3% the maltodextrin bubble of heating becomes pasty state, dries again by extruder grain with the pulverulent material mixing, makes particle.
Invention relates to a kind of method of producing magnesium citrate, and the end product quality of this technology meets and exceeds the standard of American Pharmacopeia USP30/NF25, lead content＜0.000010%, and according to the market requirement, sub-sieve gets granular and powder-product.
Embodiment
A kind of method of producing magnesium citrate provided by the invention is: it utilizes magnesiumcarbonate or magnesium oxide or magnesium hydroxide to make magnesium citrate for the reaction of raw material and edible citric acid, obtain magnesium citrate after through overcooling, crystallization, with hot deionized water washing, drying, it is embodied as:
A adds in the entry dissolving with citric acid and filters, and when temperature after heating reaches 70 ℃, begins magnesiumcarbonate or magnesium oxide or magnesium hydroxide are added gradually, and its weight ratio is 0.55/0.29/0.41: 1, and the reaction soln pH value is between 5-8;
B adds a small amount of dilute acetic acid;
C requires to carry out sub-sieve according to granularity after overcooling, crystallization, washing, drying, makes finished lemon acid magnesium crystallization or pulvis; Make particle as need, available 3% the maltodextrin bubble of heating becomes pasty state, dries again by extruder grain with the pulverulent material mixing, makes particle.
Adopt products obtained therefrom quality index of the present invention to be:
| Content (in the magnesium butt) | 14.5-16.4％ |
| Telling test | Pass Test |
| Weight loss on drying | ＜29％ |
| PH value | 5.0-9.0 |
| Muriate (CL) | ＜0.05％ |
| Vitriol (SO4) | ＜0.2％ |
| Arsenic (As) | ＜0.0003％ |
| Plumbous (Pb) | ＜0.000010％ |
| Heavy metal (in Pb) | ＜0.0010％ |
| Iron (Fe) | ＜0.02％ |
| Calcium contents (Ca) | ＜1.0％ |
| The organic volatile material | Pass Test |
| Granularity (granular) 20-80 order | ＞95％ |
Claims (3)
1, a kind of method of producing magnesium citrate, it utilizes magnesiumcarbonate or magnesium oxide or magnesium hydroxide to make magnesium citrate for the reaction of raw material and edible citric acid, through overcooling, crystallization, wash with hot deionized water, obtain magnesium citrate after the drying, it is characterized in that:
A adds in the entry dissolving with citric acid and filters, and when temperature after heating reaches 70 ℃, begins magnesiumcarbonate or magnesium oxide or magnesium hydroxide are added gradually, and the reaction soln pH value is between 5-8;
B adds a small amount of dilute acetic acid;
C requires to carry out sub-sieve according to granularity after overcooling, crystallization, washing, drying, makes finished lemon acid magnesium crystallization or pulvis.
2, a kind of method of producing magnesium citrate according to claim 1, it is characterized in that: its weight ratio of magnesiumcarbonate or magnesium oxide or magnesium hydroxide and edible citric acid is 0.55/0.29/0.41 among the step a: 1.
3, a kind of method of producing magnesium citrate according to claim 1 is characterized in that: available 3% the maltodextrin bubble of heating becomes pasty state behind the step c, dries again by extruder grain with the pulverulent material mixing, makes particle.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100434039A CN101591234A (en) | 2008-05-26 | 2008-05-26 | A kind of method of producing magnesium citrate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100434039A CN101591234A (en) | 2008-05-26 | 2008-05-26 | A kind of method of producing magnesium citrate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101591234A true CN101591234A (en) | 2009-12-02 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2008100434039A Pending CN101591234A (en) | 2008-05-26 | 2008-05-26 | A kind of method of producing magnesium citrate |
Country Status (1)
| Country | Link |
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| CN (1) | CN101591234A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102875363A (en) * | 2012-11-07 | 2013-01-16 | 如皋市江北添加剂有限公司 | Production technology of low-lead calcium citrate |
| CN104447272A (en) * | 2014-11-14 | 2015-03-25 | 宁乡新阳化工有限公司 | Production method of magnesium citrate anhydrous |
| CN106854155A (en) * | 2015-12-08 | 2017-06-16 | 中粮生物化学（安徽）股份有限公司 | A kind of preparation of magnesium salts of citric acid and preparation method thereof and the magnesium salts containing the citric acid |
| WO2018094753A1 (en) * | 2016-11-25 | 2018-05-31 | 南通市飞宇精细化学品有限公司 | Method for preparing magnesium citrate |
| WO2018094754A1 (en) * | 2016-11-25 | 2018-05-31 | 南通市飞宇精细化学品有限公司 | Method for preparing selenium citrate |
| CN109392948A (en) * | 2018-12-26 | 2019-03-01 | 安阳全丰生物科技有限公司 | A kind of fosthiazate granule and preparation method thereof |
| RU2748796C1 (en) * | 2020-10-21 | 2021-05-31 | Акционерное общество "Научно-производственное предприятие "Радий" | Method for producing magnesium citrate and its derivatives |
-
2008
- 2008-05-26 CN CNA2008100434039A patent/CN101591234A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102875363A (en) * | 2012-11-07 | 2013-01-16 | 如皋市江北添加剂有限公司 | Production technology of low-lead calcium citrate |
| CN104447272A (en) * | 2014-11-14 | 2015-03-25 | 宁乡新阳化工有限公司 | Production method of magnesium citrate anhydrous |
| CN106854155A (en) * | 2015-12-08 | 2017-06-16 | 中粮生物化学（安徽）股份有限公司 | A kind of preparation of magnesium salts of citric acid and preparation method thereof and the magnesium salts containing the citric acid |
| WO2018094753A1 (en) * | 2016-11-25 | 2018-05-31 | 南通市飞宇精细化学品有限公司 | Method for preparing magnesium citrate |
| WO2018094754A1 (en) * | 2016-11-25 | 2018-05-31 | 南通市飞宇精细化学品有限公司 | Method for preparing selenium citrate |
| CN109392948A (en) * | 2018-12-26 | 2019-03-01 | 安阳全丰生物科技有限公司 | A kind of fosthiazate granule and preparation method thereof |
| RU2748796C1 (en) * | 2020-10-21 | 2021-05-31 | Акционерное общество "Научно-производственное предприятие "Радий" | Method for producing magnesium citrate and its derivatives |
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| C12 | Rejection of a patent application after its publication | ||
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Application publication date: 20091202 |