CN101579437B - Medicinal dripping pill for treating adiposity - Google Patents
Medicinal dripping pill for treating adiposity Download PDFInfo
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- CN101579437B CN101579437B CN2008101067836A CN200810106783A CN101579437B CN 101579437 B CN101579437 B CN 101579437B CN 2008101067836 A CN2008101067836 A CN 2008101067836A CN 200810106783 A CN200810106783 A CN 200810106783A CN 101579437 B CN101579437 B CN 101579437B
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- polyethylene glycol
- dropping ball
- medicinal dropping
- weight portion
- medicinal
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Abstract
The invention discloses a medicinal dripping pill for treating adiposity, which consists of composition intermediates of red infested rice, arborvitae seed, cooked rehmannia and polyethylene glycol. The composition intermediates can be prepared from dry paste of extract of bulk drug prepared by the prior method. The medicinal dripping pill has remarkable effect of treating the adiposity and no side effects.
Description
Technical field
The present invention relates to a kind of medicinal dropping ball, particularly relate to a kind of medicinal dropping ball of treatment of obesity.
Background technology
Obesity be meant the body fat overheap and (or) distribute unusually, be a kind of multifactorial chronic metabolic disease.Inherited genetic factors, high heat, high fat diet, physical exertion are fat main cause less.The fat epidemic diseases that threatens human health that become, and suspend etc. closely related with many chronic diseases such as hypertension, dyslipidemias, diabetes, hyperlipemia, breathing sleep.Therefore, obesity is paid close attention to by the medical research person day by day.Appetite suppressant, the medicine of digesting and assimilating blocade, increase energy expenditure and Chinese medicine etc. all have therapeutical effect to obesity.
Summary of the invention
The object of the invention is to provide a kind of medicinal dropping ball of treatment of obesity.
Another object of the present invention is to provide the preparation method and the new purposes of this medicinal dropping ball.
Drop pill of the present invention is to make with the raw material of following weight portion:
Composition intermediates: Polyethylene Glycol=1: 1～4.Preferred weight part of described drop pill raw material is: composition intermediates: Polyethylene Glycol=1: 2.5,3.0 or 1: 3.5.Described Polyethylene Glycol can be a Polyethylene Glycol
2000～20000, comprise Polyethylene Glycol
2000, Polyethylene Glycol
4000, Polyethylene Glycol
6000, Polyethylene Glycol
10000Or Polyethylene Glycol
20000Deng, preferred Polyethylene Glycol
4000
The crude drug of the pharmaceutical composition intermediate of medicinal dropping ball of the present invention consists of:
Monas cuspurpureus Went 1-5 weight portion Semen Platycladi 3-8 weight portion Radix Rehmanniae Preparata 1-5 weight portion
The crude drug composition of the pharmaceutical composition intermediate of medicinal dropping ball of the present invention is preferably:
Monas cuspurpureus Went 3 weight portion Semen Platycladi 5 weight portion Radix Rehmanniaes Preparata 3 weight portions
The crude drug composition of the pharmaceutical composition intermediate of medicinal dropping ball of the present invention is preferably:
Monas cuspurpureus Went 2 weight portion Semen Platycladi 7 weight portion Radix Rehmanniaes Preparata 4 weight portions
The crude drug composition of the pharmaceutical composition intermediate of medicinal dropping ball of the present invention is preferably:
Monas cuspurpureus Went 4 weight portion Semen Platycladi 4 weight portion Radix Rehmanniaes Preparata 2 weight portions
Described composition intermediates can prepare the dried cream of each extracts of bulk drugs according to a conventional method respectively and mix and make; Also can according to a conventional method each crude drug co-extracted be prepared into the dried cream of extracts of bulk drugs and make; Described conventional method includes but not limited to water extracting method, and decoction and alcohol sedimentation technique, water extract-alcohol precipitation are crossed macropore adsorption column method, supercritical extraction etc.
The preparation method of medicinal dropping ball of the present invention is: after the Polyethylene Glycol heat fused, add composition intermediates, mix homogeneously, 75 ± 2 ℃ of insulations; Go in the coolant with dropping-pill machine, wherein the temperature of coolant is 20 ± 2 ℃, after the molding drop pill is taken out, and removes the coolant on surface, and packing promptly.Described coolant can be selected from any one in dimethicone, liquid paraffin or the vegetable oil.
Medicinal dropping ball treatment of obesity effect of the present invention significantly and have no side effect.
The present invention utilizes the solid dispersion technology principle to prepare drop pill, confirms through the test of groping property of repeated multiple times molding, with Polyethylene Glycol especially Polyethylene Glycol
4000(PEG
4000) be substrate, a system effect is best.PEG
4000After appropriate ratio and medicament mixed, the easiest fusion or the uniform dispersion of miscible formation, also the easiest dissolubility and the dissolution velocity of making type and can improving medicine.
Experiment and embodiment are used to further specify but are not limited to the present invention below.
Experimental example 1 medicinal dropping ball of the present invention (forming by water extract) reaches more than 95% through clinical treatment obesity 160 routine patient's total effective rates, obesity case diagnosis standard and criterion of therapeutical effect are pressed the Ministry of Public Health standard and are confirmed, 130 routine produce effects wherein, 20 examples effectively, 10 examples are invalid.See the following form
| Criterion of therapeutical effect | Produce effects (routine number) | Effectively (routine number) | Invalid (routine number) |
| 160 examples | 130 examples | 20 examples | 10 examples |
| Effective percentage | 81％ | 13％ | 6％ |
Experimental example 2 airpillow-dry condition researchs
Composition intermediates is 40～60 ℃, 60～80 ℃, 80～100 ℃ by temperature of charge, 20～25 liters/hour of hydrojet speed, 25～35 liters/hour, 35～40 liters/hour screen the result: when temperature of charge was 40～60 ℃, temperature of charge was low excessively, powder is difficult for dry, easily caking.Hydrojet speed is 20～25 liters/hour, and hydrojet speed is low, and flow is little, influences efficient.Hydrojet speed is 35～40 liters/hour, and hydrojet speed is fast, and powder is difficult for fully dry, easily caking.When temperature of charge was 80～100 ℃, temperature of charge was too high, may cause the decomposition of effective ingredient in the composition intermediates.So selecting temperature of charge is that the condition of 25～35 liters/hour of 60～80 ℃, hydrojet speed is carried out airpillow-dry as the airpillow-dry condition.
Experimental example 3 drop pill adjuvant screening experiment of the present invention
To The selection result, be that index is estimated with hardness, roundness, dissolve scattered time limit, yield, stability on the 7th, simultaneously test drop pill adjuvant is screened.The results are shown in following table.
Table 1 drop pill development mesostroma and coolant The selection result table
The result shows, uses PEG respectively separately
4000, PEG
6000, PEG
10000And S-40 is when doing substrate, no matter composition intermediates: adjuvant=1: 2.5, still be at 1: 3.0 1: 3.5, what molding effect was best is to use PEG separately
4000Do substrate, medicine and substrate composition be at 1: 3.0 o'clock, integration the highest (24).
Experimental example 4 optimum process condition screening experiment
Respectively the medicine in the drop pill development of the present invention is investigated with ratio (A), fluid temperature (B), coolant temperature three kinds of factors such as (C) of substrate with orthogonal experiment, every factor is got three levels; With hardness, roundness, dissolve scattered time limit, yield evaluation index as this product key property, set standards of grading and test and assess, and do statistical analysis, find out optimum process condition.The set A of orthogonal test, B, three kinds of factors of C all have certain influence to droplet ball Forming Quality of the present invention.Wherein A factor extreme difference maximum (5.667) proves that the A factor is the main factor of influence test; Next is B factor (extreme difference is 1.667); Be C factor (extreme difference is 2.500) once more; That is: A＞B＞C.A in the A factor
3(be A
K3) value maximum (18.667), prove A
3Be the auxilliary proportioning of best medicine; B in the B factor
2(be B
K2) value maximum (16.667), prove B
2Be the suitableeest fluid temperature; C in the C factor
2And C
3(be C
K2And C
K3) be worth big (16.000), prove C
2Or C
3Be the suitableeest condensing agent temperature.The main factor that the A factor is really tested for influence, and tool significant difference P＜0.05=, the B factor also has clearly influence to test, and the C factor also has certain influence to result of the test.The result shows that the optimum condition of proportioning raw materials and technical study is A
3B
2C
3Be that the drop pill raw material is composition intermediates: PEG
4000=1: 3.0, fluid temperature should be 75 ± 2 ℃; Coolant temperature is 20 ± 2 ℃.
Following embodiment all can realize the effect of above-mentioned experimental example.
The specific embodiment:
Embodiment 1:
Monas cuspurpureus Went 3kg Semen Platycladi 5kg Radix Rehmanniae Preparata 3kg
Said medicine is made the dried cream of water extract respectively according to common process, mixes, and gets composition intermediates; According to weight ratio is composition intermediates: PEG
4000=1: 3.0 ratio adds PEG
4000,, the preparation method of drop pill is: after the Polyethylene Glycol heat fused, add composition intermediates, mix homogeneously, 75 ± 2 ℃ of insulations; Go in the coolant with dropping-pill machine, wherein the temperature of coolant is 20 ± 2 ℃, after the molding drop pill is taken out, and removes the coolant on surface, and packing promptly.
Embodiment 2:
Monas cuspurpureus Went 2kg Semen Platycladi 7kg Radix Rehmanniae Preparata 4kg
Said medicine is made the dried cream of alcohol extract respectively according to common process, mixes, and gets composition intermediates; According to weight ratio is composition intermediates: PEG
6000=1: 3.5 ratio adds PEG
6000, the preparation method of drop pill is: after the Polyethylene Glycol heat fused, add composition intermediates, mix homogeneously, 75 ± 2 ℃ of insulations; Go in the coolant with dropping-pill machine, wherein the temperature of coolant is 20 ± 2 ℃, after the molding drop pill is taken out, and removes the coolant on surface, and packing promptly.
Embodiment 3:
Monas cuspurpureus Went 4kg Semen Platycladi 4kg Radix Rehmanniae Preparata 2kg
Said medicine is made water extract-alcohol precipitation according to the common process co-extracted and is crossed the dried cream of macroporous resin adsorption column extract, mixes, and gets composition intermediates; According to weight ratio is composition intermediates: PEG
4000=1: 2.5 ratio adds PEG
4000, the preparation method of drop pill is: after the Polyethylene Glycol heat fused, add composition intermediates, mix homogeneously, 75 ± 2 ℃ of insulations; Go in the coolant with dropping-pill machine, wherein the temperature of coolant is 20 ± 2 ℃, after the molding drop pill is taken out, and removes the coolant on surface, and packing promptly.
Embodiment 4:
Monas cuspurpureus Went 2kg Semen Platycladi 6kg Radix Rehmanniae Preparata 2kg
Said medicine is made water extract-alcohol precipitation according to the common process co-extracted and is crossed the dried cream of macroporous resin adsorption column extract, mixes, and gets composition intermediates; According to weight ratio is composition intermediates: PEG
4000=1: 3.0 ratio adds PEG
4000, the preparation method of drop pill is: after the Polyethylene Glycol heat fused, add composition intermediates, mix homogeneously, 75 ± 2 ℃ of insulations; Go in the coolant with dropping-pill machine, wherein the temperature of coolant is 20 ± 2 ℃, after the molding drop pill is taken out, and removes the coolant on surface, and packing promptly.
Embodiment 5:
Monas cuspurpureus Went 4kg Semen Platycladi 3kg Radix Rehmanniae Preparata 5kg
Said medicine is made the dried cream of super zero boundary extract according to the common process co-extracted, mixes, and gets composition intermediates; According to weight ratio is composition intermediates: PEG
4000=1: 3.0 ratio adds PEG
4000, the preparation method of drop pill is: after the Polyethylene Glycol heat fused, add composition intermediates, mix homogeneously, 75 ± 2 ℃ of insulations; Go in the coolant with dropping-pill machine, wherein the temperature of coolant is 20 ± 2 ℃, after the molding drop pill is taken out, and removes the coolant on surface, and packing promptly.
Claims (13)
1. the medicinal dropping ball of a treatment of obesity is characterized in that this medicinal dropping ball is to make with the raw material of following weight portion: composition intermediates: Polyethylene Glycol=1: 1～4; The crude drug of making composition intermediates consists of: Monas cuspurpureus Went 1-5 weight portion Semen Platycladi 3-8 weight portion Radix Rehmanniae Preparata 1-5 weight portion, described Polyethylene Glycol is a Polyethylene Glycol
2000～20000
2. medicinal dropping ball according to claim 1 is characterized in that this medicinal dropping ball is to make with the raw material of following weight portion: composition intermediates: Polyethylene Glycol=1: 2.5.
3. medicinal dropping ball according to claim 1 is characterized in that this medicinal dropping ball is to make with the raw material of following weight portion: composition intermediates: Polyethylene Glycol=1: 3.0.
4. medicinal dropping ball according to claim 1 is characterized in that this medicinal dropping ball is to make with the raw material of following weight portion: composition intermediates: Polyethylene Glycol=1: 3.5.
5. as the described medicinal dropping ball of one of claim 1-4, it is characterized in that described Polyethylene Glycol
2000～ 20000Comprise Polyethylene Glycol
2000, Polyethylene Glycol
4000, Polyethylene Glycol
6000, Polyethylene Glycol
10000Or Macrogol 2000 0.
6. medicinal dropping ball as claimed in claim 5 is characterized in that the preferred Polyethylene Glycol of described Polyethylene Glycol
4000
7. as the described medicinal dropping ball of one of claim 1-4, the crude drug that it is characterized in that making the pharmaceutical composition intermediate of this medicinal dropping ball consists of:
Monas cuspurpureus Went 3 weight portion Semen Platycladi 5 weight portion Radix Rehmanniaes Preparata 3 weight portions.
8. as the described medicinal dropping ball of one of claim 1-4, the crude drug that it is characterized in that making the pharmaceutical composition intermediate of this medicinal dropping ball consists of:
Monas cuspurpureus Went 2 weight portion Semen Platycladi 7 weight portion Radix Rehmanniaes Preparata 4 weight portions
9. as the described medicinal dropping ball of one of claim 1-4, the crude drug that it is characterized in that making the pharmaceutical composition intermediate of this medicinal dropping ball consists of:
Monas cuspurpureus Went 4 weight portion Semen Platycladi 4 weight portion Radix Rehmanniaes Preparata 2 weight portions.
10. as the described medicinal dropping ball of one of claim 1-4, it is characterized in that described composition intermediates prepares the dried cream of each extracts of bulk drugs according to a conventional method respectively and mixes and make.
11., it is characterized in that described composition intermediates is prepared into the dried cream of extracts of bulk drugs with each crude drug co-extracted according to a conventional method and makes as the described medicinal dropping ball of one of claim 1-4.
12., it is characterized in that this method is: after the Polyethylene Glycol heat fused, add composition intermediates, mix homogeneously, 75 ± 2 ℃ of insulations as the preparation method of one of claim 1-4 described medicinal dropping ball; Go in the coolant with dropping-pill machine, wherein the temperature of coolant is 20 ± 2 ℃, after the molding drop pill is taken out, and removes the coolant on surface, and packing promptly; Described coolant is selected from any one in dimethicone, liquid paraffin or the vegetable oil.
13. as the application of the described medicinal dropping ball of one of claim 1-4 in the medicine of preparation treatment of obesity.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101067836A CN101579437B (en) | 2008-05-15 | 2008-05-15 | Medicinal dripping pill for treating adiposity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101067836A CN101579437B (en) | 2008-05-15 | 2008-05-15 | Medicinal dripping pill for treating adiposity |
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| Publication Number | Publication Date |
|---|---|
| CN101579437A CN101579437A (en) | 2009-11-18 |
| CN101579437B true CN101579437B (en) | 2011-06-15 |
Family
ID=41361842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008101067836A Active CN101579437B (en) | 2008-05-15 | 2008-05-15 | Medicinal dripping pill for treating adiposity |
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|---|---|
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1192928A (en) * | 1997-03-11 | 1998-09-16 | 凉城县鸿茅酒厂 | Production process for medicinal liquor |
| CN101020034A (en) * | 2007-04-02 | 2007-08-22 | 李宏良 | Prepn process of medicine for treating cerebral apoplexy and its sequela |
| CN101152344A (en) * | 2007-09-24 | 2008-04-02 | 王孝文 | Wine capable of strengthening spleen and replenishing qi and prolonging life |
-
2008
- 2008-05-15 CN CN2008101067836A patent/CN101579437B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1192928A (en) * | 1997-03-11 | 1998-09-16 | 凉城县鸿茅酒厂 | Production process for medicinal liquor |
| CN101020034A (en) * | 2007-04-02 | 2007-08-22 | 李宏良 | Prepn process of medicine for treating cerebral apoplexy and its sequela |
| CN101152344A (en) * | 2007-09-24 | 2008-04-02 | 王孝文 | Wine capable of strengthening spleen and replenishing qi and prolonging life |
Non-Patent Citations (2)
| Title |
|---|
| 戴伟等.红曲胶囊调节血脂作用的人体试食研究.《预防医学文献信息》.2003,第9卷(第5期),第563-564页. * |
| 王小娟等.红曲复方制剂对大鼠血脂调节功能的影响.《陕西医学杂志》.2007,第36卷(第1期),第35-37页. * |
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|---|---|
| CN101579437A (en) | 2009-11-18 |
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