CN101564557A - Method for preparing antibiosis self-expanding material of one-off cervix dilator - Google Patents
Method for preparing antibiosis self-expanding material of one-off cervix dilator Download PDFInfo
- Publication number
- CN101564557A CN101564557A CNA200910039678XA CN200910039678A CN101564557A CN 101564557 A CN101564557 A CN 101564557A CN A200910039678X A CNA200910039678X A CN A200910039678XA CN 200910039678 A CN200910039678 A CN 200910039678A CN 101564557 A CN101564557 A CN 101564557A
- Authority
- CN
- China
- Prior art keywords
- chitosan
- polyvinyl alcohol
- antibiosis
- self
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
The invention relates to a method for preparing an antibiosis self-expanding material of a one-off cervix dilator. The method comprises the steps of: mixing chitosan or chitosan derivative with polyvinyl alcohol solution; carrying out cross-linking to form compound gel; and carrying out washing, drying, mould-pressing and shaping to obtain polyvinyl alcohol-chitosan or polyvinyl alcohol-chitosan derivative compound compressed sponge which has not only excellent water-absorbing expandability, wet mechanical strength and biological compatibility but also antibiosis and inflammation-diminishing effects. The polyvinyl alcohol- chitosan or polyvinyl alcohol-chitosan derivative compound compressed sponge can be used for preparing antibiosis one-off cervix dilator and can alleviate pain of patients in operation as well as reduce operation difficulty and occurrence of operation complicating diseases.
Description
Technical field
The present invention relates to the medical macromolecular materials field, refer in particular to a kind of preparation method that is used for the antibiosis self-expanding material of one-off cervix dilator.
Background technology
Cervical dilator is a kind of department of obstetrics and gynecology, family planning section medical surgical instrument commonly used.On the one hand, artificial abortion operation or in order to reduce the complication that some high risk pregnancy causes and to reduce perinatal mortality rate and the induced labor operation implemented needs the cervix uteri connective tissue effectively to soften and to expand; On the other hand, as Wicresoft of a kind of gynecological Clinics and Practices technology, the various operations of hysteroscope operation and mediation thereof are because of its non-incision, little, the reservation uterus of wound, do not influence the ovary endocrine function, preserve quality of life, do not have the complication of opening abdomen, hospital stays is short, post-operative recovery is fast, and advantages such as good operation effect are brought great convenience for the gynaecopathia diagnosis and treatment, and cervix dilating is extremely important to carrying out the hysteroscope operation smoothly.The cervical dilator of traditional usefulness is the dilator bar of the different-diameter made by metal or rigid plastics clinically, mode cervix dilating with the rigid expansion of physics, this mode often causes operating time longer, cause big pain to the patient, and cause vulneratio uteri, embryo's damage and untoward reaction such as hemorrhage easily.
For the slow expansion that realizes cervix uteri, alleviate patient's misery, reduce the generation of operating difficulty and complication, the slow expanding one-off cervix dilator bar that people utilize the imbibition characteristic of the good medical macromolecular materials of biocompatibility to make to have the self-expanding performance.The medical macromolecular materials of using comprise [1. Liu Hibisci Mutabilis, Xu Jine such as natural seaweed, gelatin, hydrophilic polyurethane compressed sponge, polyvinyl formal compressed sponge, the Sargassum dilator bar is to non-gravid woman's cervical dilatation observation on effect, the Qingdao medical and health, 36 (3): 166-167 (2004).2. Chinese patent CN 2061461U: gelatin cervical dilatation bolt; 3. United States Patent (USP): Osmoticcervical dilator, No.4467806.).But these self-expanding medical macromolecular materials still come with some shortcomings, and for example Sargassum dilator bar, gelatin dilator bar are after cervix uteri place absorb body fluids expands, and intensity decreases when taking out fracture and broken phenomenon may take place.Besides, existing self-expanding material lacks antibacterial and anti-inflammation functions, owing in the cervical canal of normal women, often there is some conditioned pathogen to exist, and many patients' endocervix organizes and often has the damage that brings because of inflammation or operation, therefore prevents the infection in the cervical dilatation operation very important.
Polyvinyl alcohol is a kind of hydrophilic synthesized polymer material that has good biocompatibility and have no side effect, and has suction self-expanding performance, and existing abroad polyvinyl formal compressed sponge is used for the product of one-off cervix dilator bar.Chitosan is as a kind of natural cationic polysaccharide, not only have hypotoxicity, excellent biological compatibility and biodegradability, and chitosan and derivant thereof have broad-spectrum antiseptic and antiinflammation preferably, can effectively suppress microbial growths such as antibacterial, fungus, prevents traumatic infection.It is a kind of biodegradable anti-inflammation hemostasia material compositions and the preparation method of component with the chitosan that Chinese patent CN1385216 discloses.
Summary of the invention
The present invention is directed to the deficiencies in the prior art, main purpose is to provide a kind of preparation method that is used for the antibiosis self-expanding material of one-off cervix dilator, make with this antibiosis self-expanding material to be that the one-off cervix dilator of substrate preparation not only has good imbibition, hygrometric state mechanical strength and biocompatibility, and have the effect of anti-inflammation.
To achieve these goals, the present invention adopts following technical scheme:
A kind of preparation method that is used for the antibiosis self-expanding material of one-off cervix dilator comprises following concrete steps:
(1) mixed solution of preparation polyvinyl alcohol and chitosan or chitosan derivatives;
(2) add chemical cross-linking agent in the mixed solution of step (1), mix, inject mould, standing and reacting obtains polyvinyl alcohol-chitosan or polyvinyl alcohol-chitosan derivatives composite aquogel;
(3) gained composite aquogel water is cleaned, drying, compression molding obtains polyvinyl alcohol-chitosan or polyvinyl alcohol-chitosan derivatives compound compressed sponge.
Preferred version of the present invention is as follows:
The preferred deacetylation of described chitosan is 70%～100%, molecular weight is 2000～1,000,000 chitosan.
The preferred carboxymethyl chitosan of described chitosan derivatives, sulphation chitosan and chitosan quaternary amine.
In the preferred glutaraldehyde of described chemical cross-linking agent, formaldehyde, acetaldehyde, the epoxychloropropane one or more.
The concentration of polyvinyl alcohol is 40～150g/L in the described mixed solution of step (1), and the mass ratio of chitosan or chitosan derivatives and polyvinyl alcohol is (0.1～20): 100.
The standing and reacting temperature is a room temperature to 60 ℃ in the step (2), dry preferably freeze drying in the step (3).
The invention has the advantages that the polyvinyl alcohol-chitosan or the polyvinyl alcohol-chitosan derivatives composite aquogel of preparation chemical crosslinking, then through cleaning, dry, compression molding, make polyvinyl alcohol-chitosan or polyvinyl alcohol-chitosan derivatives compressed sponge, promptly obtain a kind of antibiosis self-expanding material that is used for one-off cervix dilator, it not only has good imbibition, hygrometric state mechanical strength and biocompatibility, and has an effect of anti-inflammation, alternative existing self-expanding macromolecular material is used to prepare the one-off cervix dilator bar with anti-microbial property, alleviates patient's misery in operation, reduce the generation of operating difficulty and complication.
The specific embodiment
Below in conjunction with specific embodiment the present invention is further described.
Embodiment 1
(1) 4.0g polyvinyl alcohol and 0.4g chitosan (deacetylation 90%, molecular weight 20000) heating for dissolving are cooled to room temperature in the acetic acid,diluted of 80mL, obtain polyvinyl alcohol/chitosan mixed solution;
(2) glutaraldehyde solution of the 0.32mol/L of adding 20mL in the polyvinyl alcohol-chitosan mixed solution of step (1) preparation fully stirs, and in 60 ℃ of reactions 1 hour, room temperature left standstill 24 hours, obtained crosslinked polyvinyl alcohol-chitosan plural gel.
(3) polyvinyl alcohol-chitosan plural gel water that obtains is fully cleaned, lyophilization, compression molding obtains polyvinyl alcohol-chitosan compressed sponge rod again.After this compressed sponge rod suction diameter expansion 300%, tensile strength is 1.8MPa, is 90.4% to staphylococcus aureus ATCC6538 bacteriostasis rate, and strong bacteriostasis is arranged, and can be used as the antibiosis self-expanding material of one-off cervix dilator.
Embodiment 2
(1) 10.0g polyvinyl alcohol and 2.0g chitosan (deacetylation 100%, molecular weight 5000) heating for dissolving are cooled to room temperature in the acetic acid,diluted of 80mL, obtain polyvinyl alcohol-chitosan mixed solution;
(2) glutaraldehyde solution of the 0.43mol/L of adding 20mL in the polyvinyl alcohol-chitosan mixed solution of step (1) preparation fully stirs, and in 50 ℃ of reactions 1 hour, room temperature left standstill 24 hours, obtained crosslinked polyvinyl alcohol-chitosan plural gel.
(3) polyvinyl alcohol-chitosan plural gel water that obtains is fully cleaned, lyophilization, compression molding obtains polyvinyl alcohol-chitosan compressed sponge rod again.After this compressed sponge rod suction diameter expansion 300%, tensile strength is 2.1MPa, is 92.1% to staphylococcus aureus ATCC6538 bacteriostasis rate, and strong bacteriostasis is arranged, and can be used as the antibiosis self-expanding material of one-off cervix dilator.
Embodiment 3
(1) with 10.0g polyvinyl alcohol and 0.5g sulphation chitosan heating for dissolving in the water of 80mL, be cooled to room temperature, obtain polyvinyl alcohol-sulphation chitosan mixed solution;
(2) formalin of the 0.43mol/L of adding 20mL in the polyvinyl alcohol-sulphation chitosan mixed solution of step (1) preparation, fully stir, in 50 ℃ of reactions 2 hours, room temperature left standstill 24 hours, obtained crosslinked polyvinyl alcohol-sulphation chitosan plural gel.
(3) polyvinyl alcohol-sulphation chitosan plural gel water that obtains is fully cleaned, lyophilization, compression molding obtains polyvinyl alcohol-sulphation chitosan compressed sponge rod again.After this compressed sponge rod suction diameter expansion 300%, tensile strength is 2.2MPa, is 91.4% to staphylococcus aureus ATCC6538 bacteriostasis rate, and strong bacteriostasis is arranged, and can be used as the antibiosis self-expanding material of one-off cervix dilator.
Embodiment 4
(1) with 10.0g polyvinyl alcohol and 1.0g carboxymethyl chitosan heating for dissolving in the water of 80mL, be cooled to room temperature, obtain polyvinyl alcohol-carboxymethyl chitosan mixed solution;
(2) glutaraldehyde solution of the 0.43mol/L of adding 20mL in the polyvinyl alcohol-carboxymethyl chitosan mixed solution of step (1) preparation fully stirs, and in 50 ℃ of reactions 24 hours, obtains crosslinked polyvinyl alcohol-carboxymethyl chitosan plural gel.
(3) polyvinyl alcohol-carboxymethyl chitosan plural gel water that obtains is fully cleaned, lyophilization, compression molding obtains polyvinyl alcohol-carboxymethyl chitosan compressed sponge rod again.After this compressed sponge rod suction diameter expansion 300%, tensile strength is 2.0MPa, is 80.1% to staphylococcus aureus ATCC6538 bacteriostasis rate, and bacteriostasis is arranged, and can be used as the antibiosis self-expanding material of one-off cervix dilator.
Embodiment 5
(1) with 10.0g polyvinyl alcohol and 0.8g chitosan quaternary amine heating for dissolving in the water of 80mL, be cooled to room temperature, obtain polyvinyl alcohol-chitosan quaternary amine mixed solution;
(2) glutaraldehyde solution of the 0.43mol/L of adding 20mL in the polyvinyl alcohol-chitosan quaternary amine mixed solution of step (1) preparation fully stirs, and in 50 ℃ of reactions 24 hours, obtains crosslinked polyvinyl alcohol-chitosan quaternary amine pluralgel.
(3) polyvinyl alcohol-chitosan quaternary amine pluralgel water that obtains is fully cleaned, lyophilization, compression molding obtains polyvinyl alcohol-chitosan quaternary amine compressed sponge rod again.After this compressed sponge rod suction diameter expansion 300%, tensile strength is 2.2MPa, is 95.0% to staphylococcus aureus ATCC6538 bacteriostasis rate, and strong bacteriostasis is arranged, and can be used as the antibiosis self-expanding material of one-off cervix dilator.
To sum up each embodiment as can be known, polyvinyl alcohol-chitosan that the present invention is prepared or polyvinyl alcohol-chitosan derivatives compound compressed sponge not only has good imbibition, hygrometric state mechanical strength and biocompatibility, and has an effect of anti-inflammation, alternative existing self-expanding macromolecular material is used to prepare the one-off cervix dilator bar with anti-microbial property, alleviates the generation of patient's misery, minimizing operating difficulty and complication in operation.
The above, it only is preferred embodiment of the present invention, be not that technical scope of the present invention is imposed any restrictions, so every foundation technical spirit of the present invention all still belongs in the scope of technical solution of the present invention any trickle modification, equivalent variations and modification that above embodiment did.
Claims (10)
1, a kind of preparation method that is used for the antibiosis self-expanding material of one-off cervix dilator is characterized in that: may further comprise the steps
(1) mixed solution of preparation polyvinyl alcohol and chitosan;
(2) add chemical cross-linking agent in the mixed solution of step (1), mix, inject mould, standing and reacting obtains polyvinyl alcohol-chitosan composite aquogel;
(3) gained composite aquogel water is cleaned, drying, compression molding obtains polyvinyl alcohol-chitosan compound compressed sponge.
2, the preparation method that is used for the antibiosis self-expanding material of one-off cervix dilator according to claim 1 is characterized in that: described chitosan selects that deacetylation is 70%～100% for use, molecular weight is 2000～1,000,000 chitosan.
3, the preparation method that is used for the antibiosis self-expanding material of one-off cervix dilator according to claim 1, it is characterized in that: the concentration of polyvinyl alcohol is 40～150g/L in the described mixed solution of step (1), and the mass ratio of chitosan and polyvinyl alcohol is (0.1～20): 100.
4, the preparation method that is used for the antibiosis self-expanding material of one-off cervix dilator according to claim 1 is characterized in that: described chemical cross-linking agent is one or more in glutaraldehyde, formaldehyde, acetaldehyde, the epoxychloropropane.
5, the preparation method that is used for the antibiosis self-expanding material of one-off cervix dilator according to claim 1 is characterized in that: the described standing and reacting temperature of step (2) is a room temperature to 60 ℃, and the described drying of step (3) is lyophilization.
6, a kind of preparation method that is used for the antibiosis self-expanding material of one-off cervix dilator is characterized in that: may further comprise the steps
(1) mixed solution of preparation polyvinyl alcohol and chitosan derivatives;
(2) add chemical cross-linking agent in the mixed solution of step (1), mix, inject mould, standing and reacting obtains polyvinyl alcohol-chitosan derivatives composite aquogel;
(3) gained composite aquogel water is cleaned, drying, compression molding obtains polyvinyl alcohol-chitosan derivatives compound compressed sponge.
7, the preparation method that is used for the antibiosis self-expanding material of one-off cervix dilator according to claim 6 is characterized in that: described chitosan derivatives is selected carboxymethyl chitosan, sulphation chitosan or chitosan quaternary amine for use.
8, the preparation method that is used for the antibiosis self-expanding material of one-off cervix dilator according to claim 6, it is characterized in that: the concentration of polyvinyl alcohol is 40～150g/L in the described mixed solution of step (1), and the mass ratio of chitosan derivatives and polyvinyl alcohol is (0.1～20): 100.
9, the preparation method that is used for the antibiosis self-expanding material of one-off cervix dilator according to claim 6 is characterized in that: described chemical cross-linking agent is one or more in glutaraldehyde, formaldehyde, acetaldehyde, the epoxychloropropane.
10, the preparation method that is used for the antibiosis self-expanding material of one-off cervix dilator according to claim 6 is characterized in that: the described standing and reacting temperature of step (2) is a room temperature to 60 ℃, and the described drying of step (3) is lyophilization.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910039678.XA CN101564557B (en) | 2009-05-25 | 2009-05-25 | Method for preparing antibiosis self-expanding material of one-off cervix dilator |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910039678.XA CN101564557B (en) | 2009-05-25 | 2009-05-25 | Method for preparing antibiosis self-expanding material of one-off cervix dilator |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101564557A true CN101564557A (en) | 2009-10-28 |
| CN101564557B CN101564557B (en) | 2014-01-01 |
Family
ID=41281032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200910039678.XA Active CN101564557B (en) | 2009-05-25 | 2009-05-25 | Method for preparing antibiosis self-expanding material of one-off cervix dilator |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101564557B (en) |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102921097A (en) * | 2011-08-10 | 2013-02-13 | 史凤阳 | Liquid absorbing expansion type tract dilator |
| CN102921098A (en) * | 2011-08-10 | 2013-02-13 | 辽宁爱母医疗科技有限公司 | Application of water absorbing material to medical tract dilator |
| CN103528474A (en) * | 2013-05-17 | 2014-01-22 | 哈尔滨欧替药业有限公司 | Detection method for vaginal expansion plug |
| CN104558988A (en) * | 2013-10-11 | 2015-04-29 | 上海工程技术大学 | High-elasticity strong-hydroscopicity chitosan sponge allowing normal-temperature drying and preparation method thereof |
| CN104998298A (en) * | 2015-06-16 | 2015-10-28 | 常州大学 | Chitosan support achieving directional hole forming and preparation method of chitosan support |
| CN106137454A (en) * | 2016-08-02 | 2016-11-23 | 青海省畜牧兽医科学院 | A kind of assembly of cervical dilatation before cattle embryo transfer |
| CN107510880A (en) * | 2017-03-28 | 2017-12-26 | 杭州爱光医疗器械有限公司 | Disposable micro- noninvasive injecting type cervical dilator and its processing method |
| WO2018113147A1 (en) * | 2016-12-20 | 2018-06-28 | 欣乐加生物科技有限公司 | Dry gel sponge of super water-absorbent polymer hydrogel, preparation method therefor and use thereof |
| CN110177595A (en) * | 2016-10-06 | 2019-08-27 | 麦迪凯姆技术有限股份公司 | Combined osmotic hydrogel cervical dilator and preparation method thereof |
| CN110585570A (en) * | 2019-09-17 | 2019-12-20 | 北京中杰瑞康科技发展有限责任公司 | Liquid-absorbing expansion self-adaptive and antibacterial dilating cervical dilator and preparation method thereof |
| CN111195173A (en) * | 2018-11-19 | 2020-05-26 | 江苏昌吉永生物科技股份有限公司 | Injection type hemostatic applicator and preparation method thereof |
| CN113119369A (en) * | 2021-05-24 | 2021-07-16 | 爱光生物医药(南昌)有限公司 | Method for forming inert end part of disposable cervical dilating rod |
-
2009
- 2009-05-25 CN CN200910039678.XA patent/CN101564557B/en active Active
Non-Patent Citations (3)
| Title |
|---|
| 吴国杰: "壳聚糖／聚乙烯醇水凝胶的硬度研究", 《材料导报》 * |
| 吴国杰: "聚乙烯醇-壳聚糖互穿网络水凝胶的合成与性能研究", 《现代化工》 * |
| 吴炜亮: "聚乙烯醇—壳聚糖水凝胶机械性能的研究", 《广东工业大学学报》 * |
Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2742966A4 (en) * | 2011-08-10 | 2015-04-01 | Liaoning Aimu Medical Science & Technology Co Ltd | Application of water-absorption material in medical cavity channel expander |
| CN102921098A (en) * | 2011-08-10 | 2013-02-13 | 辽宁爱母医疗科技有限公司 | Application of water absorbing material to medical tract dilator |
| CN102921097A (en) * | 2011-08-10 | 2013-02-13 | 史凤阳 | Liquid absorbing expansion type tract dilator |
| CN103528474B (en) * | 2013-05-17 | 2016-03-30 | 哈尔滨欧替药业有限公司 | A kind of detection method for vaginal expansion plug |
| CN103528474A (en) * | 2013-05-17 | 2014-01-22 | 哈尔滨欧替药业有限公司 | Detection method for vaginal expansion plug |
| CN104558988A (en) * | 2013-10-11 | 2015-04-29 | 上海工程技术大学 | High-elasticity strong-hydroscopicity chitosan sponge allowing normal-temperature drying and preparation method thereof |
| CN104998298A (en) * | 2015-06-16 | 2015-10-28 | 常州大学 | Chitosan support achieving directional hole forming and preparation method of chitosan support |
| CN106137454A (en) * | 2016-08-02 | 2016-11-23 | 青海省畜牧兽医科学院 | A kind of assembly of cervical dilatation before cattle embryo transfer |
| CN106137454B (en) * | 2016-08-02 | 2018-01-09 | 青海省畜牧兽医科学院 | A kind of component for cervical dilatation before ox embryo transfer |
| CN110177595A (en) * | 2016-10-06 | 2019-08-27 | 麦迪凯姆技术有限股份公司 | Combined osmotic hydrogel cervical dilator and preparation method thereof |
| EP3560524A4 (en) * | 2016-12-20 | 2020-08-05 | Solaplus Biotechnology Co., Ltd | Dry gel sponge of super water-absorbent polymer hydrogel, preparation method therefor and use thereof |
| WO2018113147A1 (en) * | 2016-12-20 | 2018-06-28 | 欣乐加生物科技有限公司 | Dry gel sponge of super water-absorbent polymer hydrogel, preparation method therefor and use thereof |
| RU2759898C2 (en) * | 2016-12-20 | 2021-11-18 | Солаплас Байотекнолоджи Ко., Лтд | Superabsorbent polymer hydrogel xerogel sponge, method for production and application thereof |
| CN107510880A (en) * | 2017-03-28 | 2017-12-26 | 杭州爱光医疗器械有限公司 | Disposable micro- noninvasive injecting type cervical dilator and its processing method |
| CN107510880B (en) * | 2017-03-28 | 2024-01-19 | 杭州市第一人民医院 | Disposable minimally invasive injection cervical dilator and processing method thereof |
| CN111195173A (en) * | 2018-11-19 | 2020-05-26 | 江苏昌吉永生物科技股份有限公司 | Injection type hemostatic applicator and preparation method thereof |
| CN110585570A (en) * | 2019-09-17 | 2019-12-20 | 北京中杰瑞康科技发展有限责任公司 | Liquid-absorbing expansion self-adaptive and antibacterial dilating cervical dilator and preparation method thereof |
| CN110585570B (en) * | 2019-09-17 | 2022-06-14 | 北京中杰瑞康科技有限公司 | Liquid-absorbing expansion self-adaptive and antibacterial dilating cervical dilator and preparation method thereof |
| CN113119369A (en) * | 2021-05-24 | 2021-07-16 | 爱光生物医药(南昌)有限公司 | Method for forming inert end part of disposable cervical dilating rod |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101564557B (en) | 2014-01-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101564557B (en) | Method for preparing antibiosis self-expanding material of one-off cervix dilator | |
| CN105194740B (en) | A kind of post-operation adhesion preventing hydrogel and preparation method thereof | |
| CN109942905B (en) | Composite hydrogel material and preparation method thereof | |
| CN101574539B (en) | Gelatin sponge and preparation method thereof | |
| US7262181B2 (en) | Water soluble cellulose etherified derivatives styptic materials | |
| CN102526795A (en) | Chitosan-based styptic sponge and preparation method thereof | |
| CN108273121B (en) | Metakaolin based hemostatic sponge material and preparation method thereof | |
| CN102139123A (en) | Method for preparing intra-operative hemostatic material by cross emulsification of plant starch | |
| CN101695581A (en) | Method for preparing human-like collagen haemostatic sponge in scale | |
| CN107261193B (en) | Hemostatic material and preparation method thereof | |
| CN112121032B (en) | Hydrogel patch for skin care and preparation method thereof | |
| CN1775302A (en) | Chitose-gelatine sponge wound dressing preparing method | |
| CN106110367A (en) | Based on natural polymer MULTILAYER COMPOSITE medical dressing and preparation method thereof | |
| CN102144988A (en) | Chitosan cervix uteri anti-microbial membrane and preparation method thereof | |
| CN113663120A (en) | Hemostatic sponge cushion core and preparation method thereof | |
| CN109111591A (en) | It is a kind of carry medicine styptic sponge preparation method and its preparation load medicine styptic sponge | |
| CN105497964A (en) | Fucoidin-alginate sponge and preparation method thereof | |
| CN107349464B (en) | Preparation method of novel medical hemostatic gel dressing | |
| CN105854161A (en) | Cervical anti-adhesion dilating rod as well as preparation method and application thereof | |
| CN113425889B (en) | Antibacterial hemostatic sponge and preparation method and application thereof | |
| CN106913899A (en) | Plant polyose styptic sponge is prepared using secondary freezing | |
| CN104558988A (en) | High-elasticity strong-hydroscopicity chitosan sponge allowing normal-temperature drying and preparation method thereof | |
| KR102294242B1 (en) | Instrument for preventing adhesion of uterine cervix with dressing material | |
| JP2004323454A (en) | Medicinal agent | |
| Zhang et al. | Body temperature-induced adhesive hyaluronate/gelatin-based hybrid hydrogel dressing for promoting skin regeneration |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |