CN101564495A - Series medicaments for psychosis negative four-step therapy - Google Patents

Abstract

The invention discloses series medicaments for psychosis negative four-step therapy and belongs to the technical fields of Chinese medicaments. For negative initial stage symptoms, a true yin guarding decoction prepared from ganoderma sinense, Chinese magnoliavine fruit, Chinese wolfberry, white mume flower, flower of silktree albizzia, bark of silktree albizzia, thinleaf milkwort root-bark and the like is applied; for negative light stage symptoms, a yang-strengthening and yin-repressing decoction prepared from heterophylly falsestarwort root, the ganoderma sinense, tall gastrodia tuber, raidx astragali, manyflower solomonseal rhizome and the like is applied besides the true yin guarding decoction; for negative moderate stage symptoms, a yang-strengthening and consciousness-restoring decoction prepared form the ginseng, the ganoderma sinense, the tall gastrodia tuber, officinal magnolia bark, the white mume flower and the like is applied besides the yang-strengthening and yin-repressing decoction; and for negative severe stage symptoms, a yang-warming and exciting decoction prepared from the ginseng, the ganoderma sinense, the tall gastrodia tuber and the like is applied besides the yang-strengthening and consciousness-restoring decoction. Based on negative category and the four-step therapy of psychosis, the series medicaments are applied according to different properties and stages. And the series medicaments achieve exact treatment effect, high cure rate and no relapse.

Description

Series medicaments for psychosis negative four-step therapy

Technical field

The present invention relates to technical field of Chinese medicines, be specially series medicaments for psychosis negative four-step therapy.

Background technology

Psychosis is a kind of very complicated difficult disease, and the course of disease is long, radical cure is difficult, makes the patient can't orthobiosis and work, and brings white elephant for family and society.Because the Chinese and western medicine basic theories is different with the starting point, the Chinese and western drugs role also is not quite similar.To same a kind of disease, western medicine is conceived to the control of nervus centralis, and used Western medicine can suppress or excitement the nerve that the patient carries out in various degree as stable, chlorpromazine, clozapine, trifluoperazine, penfluridol etc., and advantage is: recent instant effect.Shortcoming is: long-range weak curative effect or finally lose curative effect and take side effect for a long time strong greater than curative effect, dependency addiction, in case drug withdrawal, easily recurrence.Can damage hepatic and renal function again, cause many diseases.As: hypertension, diabetes, granulocytopenia etc.Take for a long time and can cause lethargy, stiff blunt, puffiness due to deficiency is unable, and brain is in a trance.And patient can increase the weight of the state of an illness to the feared state of mind of these medicines, so that causes vicious cycle.To be Western medicine be conceived to neural temporary transient control to psychotic treatment to reason, and the patient is carrying out corresponding sign when checking to neural, brain, as brain CT, and electroencephalogram, magnetic resonance can not be found any problem.Although this illustrates this treatment superficial phenomenon instant effect, is a kind of Therapeutic Method of conservative maintenance.

Theory of Chinese medical science thinks that the people always has the seven emotions and the six sensory pleasures, when people when meeting with setback, will produce various thought pressures and mental burden on life and cause, can reduce several emotions such as " happiness, anger, melancholy, think of, compassions, fear, shy " in the theory of Chinese medical science.When a certain emotion runs up to a certain degree, will have influence on the balance of inside of human body internal organs by quantitative change to qualitative change, and then cause spiritual aspect to go wrong.Though with treatment by Chinese herbs this when sick the used time long than the Western medicine time, advantage also is tangible.Calculate total course of treatment by recovery from illness, treatment by Chinese herbs is faster than Western medicine.Short treating period, expense is low.Crucial difference is: Western medicine is finally disabled, and Chinese medicine is finally cured.Traditional tcm therapy requires comprehensive measure, but because psychosis is a kind of very complicated difficult disease, the different obtained effects of the method for controlling of executing have very significant difference.

The uncommon. A Disen in American scholar south is with conclusion two major types of schizophrenia system.Promptly negative and positive.Be subjected to the attention of various countries and adopt, make the situation of world's schizophrenia typing confusion that one basic standard arranged, and distant corresponding and propose in Chinese bimillennium approximately " difficult through ".The theory of " be mad the Double Ninth Festival, and overabundant yin is insane ".19 syndromes have been contained in the wherein negative four big primary symptom contents.30 syndromes have been contained in the sun disease four big primary symptom contents.Substantially all psychosiss have been summarized, negative and male fundamental symptoms.

Feminine gender is the resembling of " deficiency " of traditional Chinese medical science understanding.What deficiency? be exactly insufficiency of vital energy and blood, insufficiency of kidney-YANG, the active substance in vivo deficiency of functions of physical supply, the scarce capacity of meridians conduction.Such as plant, there is not competent liquid manure sunlight listless cannot not wither strongly.Full of life and energy, broken off the water food, will become the disease worm and rely cat.Someone says that negative patient's living standard is not low, can not be nutrition problem.This is the unilateral view that know only a part of the story.The people is a superior being, and all vital movements all have the participation of emotion consciousness.Digestive organs are more unexceptional.Mental maladjustment, negative feeling directly influences precise and tiny the digesting and assimilating and utilizing in vivo of grain rice, affects food quantitative change and qualitative change in vivo.Healthy people can digest and assimilate the water food, becomes energy.The supply vital movement is required.This type of patient then becomes water food into phlegm-damp or unnecessary fat, makes us puffiness due to deficiency, or becomes the dead blood of old expectorant and make us becoming thin.So negative patient's " deficiency " though the indigestion and loss of appetite phenomenon of lack of appetite is arranged, neither singly can solve with tonic.Promptly be integration of edible and medicinal herbs, but the homology same sex not.Medicine has specific intelligence, not comparability of food is arranged, the effect that can not replace.Resembling of negative patient so " deficiency ".Must fill its weak point with relevant medicine.Negative and positive are unities of opposites, and solitary YIN is not given birth to, and lonely sun is not long.The negative patient lacks is exactly manlyly to rouse oneself, so, supporing yang be when be engaged in earlier.

Make a general survey of Chinese medicine at all times, with psychosis typing prescription, (doctor trained in Western medicine is according to the symptom typing, and the traditional Chinese medical science is according to the pulse condition typing) fails type is write out a prescription by stages separately, and this is mistaken ideas.All types of psychotic symptoms are not sick complete sending out, increase the weight of but constantly develop, and be the result of quantitative change qualitative change.Pathotype moves, the different course of disease stages, and different evolution process, the symptom of expression is different.As the prescription of finalizing the design, a journey is constant, takes measures regardless of changes in circumstances exactly.Will in initial phase or slight phase, who can make a definite diagnosis it develop into schizophrenia such as the state of an illness? whom has can affirm that it can not increase the weight of to become Split disease again? so typing must be only and shoot the arrow at the target by stages.Try provincial authoritative mental hospital, countries in the world, the permanent patient more than 10 years is all arranged in which hospital.The oral chemical drugs of their tens of year's harvest cars cannot be cured all one's life, and is enough to illustrate dead end, and the rehabilitation persistent ailment must look for another way.Therefore divide the peculiar property of disease according to essence.Clinical practice, course of disease evolving stage, by stages, the flexible treatment that pathological changes side becomes is only effective treatment of real system in the type.

Summary of the invention

Discovering according to long-term clinical observation, is not separately schizophrenia, and all functional psychosiss all are along just sending out symptom, and---this four steps track of mild---moderate symptom---severe symptom develops.Taking a turn for the better also is to return according to this former road of four step tracks, i.e. four-step therapeutics.Be acute evolving stage weak point, chronic evolving stage is long.

The purpose of this invention is to provide a kind of series medicaments for psychosis negative four-step therapy, this medicine is classified and four-step therapeutics based on psychosis negative, according to different character, and the different stages, to execute and control different medicines, curative effect is sure, and the cure rate height does not have recurrence.

Relevant by stages in medicine series provided by the present invention and psychosis negative and the four kinds of types, negative symptoms defines as follows:

Negative four primary symptoms	Syndrome	Severe phase syndrome	Moderate phase syndrome	Slight phase syndrome	The initial phase syndrome
						One, flat affect or blunt	1, facial expression seldom changes; 2, autokinesis reduces; 3, the posture expression is poor; The contact of 4 expressions in the eyes is poor; 5, apathy reaction; 6, emotion is not appropriate; 7, intonation lacks fluctuation.	1, apathy reaction; 2, emotion is not appropriate; 3, facial expression seldom changes; 4, the posture expression is poor.	1, expression in the eyes contact differs from 2, intonation lacks fluctuation.	1, autokinesis reduces.	More preceding fatiguability, weak
Two, the poverty of thought	1, flat, monotonous language; 2, language content poorness; 3, speech is interrupted; 4, reply blunt.	1, flat, monotonous language; Weary 2, speech is interrupted.	1, reply blunt.	1, language content poorness.	1, more preceding language reduces; 2, forgetful, dream is many.
						Three, aboulia	1, clothing and Personal hygiene are poor; 2, work and study can not be lasting; 3, body is moving less; 4, amusement excitement reduces; 5, sexual activity reduces; 6, intimate sense lacks; 7, friend-making interest descends.	1, body is moving less; 2, intimate sense lacks	1, clothing and Personal hygiene are poor; 2, amusement excitement reduces; 3, sexual activity reduces;	1, work and study can not be lasting; 2, friend-making interest descends.	1, initiative is more preceding poor; 2, sleep more and do not recover from fatigue.
Four, attention deficit disorder	1, do not note social activity; Note when 2, talking not concentrating.	1, do not note social activity; Note when 2, talking not concentrating.	Note when 1, talking not concentrating.	1, do not note social activity.	1, more preceding social activity is low.

The technical scheme that technical solution problem of the present invention is taked is:

Scheme one, series medicaments for psychosis negative four-step therapy, it is characterized in that, for negative severe phase symptom, be to be made by following bulk drugs: Radix Ginseng 15, Ganoderma sinense Zhao Xu et Zhang 15, Rhizoma Gastrodiae 15, Cortex Magnoliae Officinalis 10, Flos Pruni mume 6, Flos Albiziae 20, Rhizoma Chuanxiong 12, Radix Angelicae Sinensis 15, Rhizoma Atractylodis Macrocephalae preparata 15, Fructus Hordei Germinatus (parched to brown) 10, Fructus Crataegi (parched to brown) 10, Massa Medicata Fermentata (parched to brown) 10, Rhizoma Anemones Altaicae 12, Cortex Cinnamomi 10, Ramulus Cinnamomi 15, the Radix Astragali 20 and Rhizoma Zingiberis 6 are fried in shallow oil Tang Ri clothes secondary; Lignum Aquilariae Resinatum 1.5, Cornu Cervi Pantotrichum 1.5 and Aspongopus 1.5 are ground into powder early, take after mixing it with water for late twice.For ease of distinguishing the excited soup of this medicine called after warming YANG.

The side separates: Radix Ginseng, the Radix Astragali, Rhizoma Gastrodiae, Ganoderma sinense Zhao Xu et Zhang, Cornu Cervi Pantotrichum, Aspongopus, Cortex Cinnamomi, Ramulus Cinnamomi, Rhizoma Zingiberis are monarch.Deep the moon fills the air internal organs, and non-one or two flavors can be competent at, need entire team to set out, and with great strength and vigour, the YANG invigorating the moon that disappears is inspired yang-energy, and exertion is spiritual.Qi of zang-fu viscera, the sun of integral body, exhaustive, Rhizoma Gastrodiae is a key medicine of controlling brain, all encephalopathys of controlling are essential, have the supporing yang merit of eliminating the phlegm and having one's ideas straightened out of arresting convulsion concurrently.With all monarch drug connection 5, more attain curative effect.Cloudy gas is vigorous, and positive internal organs must decrease, and the paddy sea must stagnate.With JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) (Fructus Hordei Germinatus (parched to brown), Fructus Crataegi (parched to brown) and Massa Medicata Fermentata (parched to brown)), Rhizoma Atractylodis Macrocephalae preparata, Cortex Magnoliae Officinalis are minister, and the consumer product dredge stasis of jointly launching an attack is destroyed the decadent force easily, and push away wall and fall wall, and making does not cloudyly have institute and comply with, and Yang Dean deposits.The assistant Rhizoma Anemones Altaicae is eliminated phlegm for resuscitation simply, is intended to the moon and goes out to have the road, and sun goes into to have door.Flos Pruni mume, Flos Albiziae, Lignum Aquilariae Resinatum, fragrance diffusion, meaning is pleased in refreshment, and disappear resentment and Rhizoma Acori Graminei of resolving depression is adjuvant drug altogether.Rhizoma Chuanxiong, make when being classified as, the gas medicine in the blood draws all medicines, drives outside cloudy turbid and the internal organs blood network, carries the sun of all medicines, and the circumfluence whole body is irrigated in the extremity bones of the body collectively.So execute and control, cloudy turbid be so incensed that sun and loose, Kidney-Yin unit, De Yang and giving birth to makes a general survey of YIN pathogen to cause a disease, not outer cold-phlegm, tired, the blood clotting of wetting and so on.Hereat, all heresies are with cutting down, and Zhu Yangqi advances, and take into account each other, and treating both the principal and the secondary aspects of a disease at the same time is imitated with boiling Tang Poxue, wouldn't the disease of feminine gender speed be separated? but this side's YANG invigorating is high excessively, can not use for a long time, one course of treatment of 15-30 agent, potion on the one, divide early, late secondary clothes down.The YANG invigorating refreshment soup at negative moderate phase symptom is used in easy second step treatment of remission instead.

Scheme two, series medicaments for psychosis negative four-step therapy, it is characterized in that, for negative moderate phase symptom, be to be made by following bulk drugs: Radix Ginseng 15, Ganoderma sinense Zhao Xu et Zhang 15, Rhizoma Gastrodiae 15, Cortex Magnoliae Officinalis 10, Flos Pruni mume 6, Flos Albiziae 20, Rhizoma Chuanxiong 12, Radix Angelicae Sinensis 15, Rhizoma Atractylodis Macrocephalae preparata 15, Fructus Hordei Germinatus (parched to brown) 10, Fructus Crataegi (parched to brown) 10, Massa Medicata Fermentata (parched to brown) 10 and Rhizoma Anemones Altaicae 12 are fried in shallow oil Tang Ri clothes secondary; Lignum Aquilariae Resinatum 1.5, Cornu Cervi Pantotrichum 1.5 and Aspongopus 1.5 are ground into powder early, take after mixing it with water for late twice.For ease of distinguishing this medicine called after YANG invigorating refreshment soup.

The side separates: with Radix Ginseng, the Radix Astragali, Ganoderma sinense Zhao Xu et Zhang, Rhizoma Gastrodiae, Cornu Cervi Pantotrichum, Aspongopus is monarch, continues to build Yuanyang, and brain-care shakes and sends out spirit.JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) (Fructus Hordei Germinatus (parched to brown), Fructus Crataegi (parched to brown) and Massa Medicata Fermentata (parched to brown)), Rhizoma Atractylodis Macrocephalae preparata are minister, the internal organs of space taste middle-jiao yang, function of the spleen and stomach.Make central hinge life active, reach down on logical, ascending the clear and descending the turbid is intended to that Earth produces myriads of things, and training mends that day after tomorrow life is basic, and cloudy gas is crossed Sheng, and middle-jiao yang, function of the spleen and stomach must be hindered, and ten thousand can not neglect.Flos Pruni mume, Flos Albiziae, Lignum Aquilariae Resinatum are adjuvant drug, and sweet perfumes are diffused all around, and the moon that disappears is warded off dirty, and meaning is pleased in refreshment.The warm medicine that Rhizoma Anemones Altaicae is eliminated phlegm for resuscitation, fluent yang-energy.Be intended to the moon and go out to have the road, sun goes into to have door.Assist a ruler in governing a country the monarch and his subjects and make curative effect altogether.Rhizoma Chuanxiong, make when being classified as, the gas medicine in the blood draws all medicines and drives outside cloudy turbid and the internal organs blood network, carries the sun of all medicines, and the circumfluence whole body is irrigated the extremity bones of the body collectively.So execute art, reinforcing YIN-essence must press down, weak positive must assisting, and its disease must be separated.One course of treatment of 15-30 agent, potion on the one, divide early, late secondary clothes down.But the positive work partially of this side is for a long time with fearing.Cardinal symptom is eliminated, and in easy the 3rd step, continues and uses the invigorating YANG at the slight phase symptom of feminine gender to press down cloudy soup.

Scheme three, series medicaments for psychosis negative four-step therapy, it is characterized in that, for the slight phase symptom of feminine gender, be to make: Radix Pseudostellariae 15, Ganoderma sinense Zhao Xu et Zhang 10, Rhizoma Gastrodiae 15, the Radix Astragali 15, Rhizoma Polygonati 15, Fructus Hordei Germinatus (parched) 12, Rhizoma Atractylodis Macrocephalae preparata 12, Flos Pruni mume 5, Flos Albiziae 15, Cortex Albiziae 15, Radix Bupleuri 15, Os Draconis 30, Dens Draconis 20, Concha Ostreae 20, Caulis Polygoni Multiflori 15, Radix Angelicae Sinensis 15 and Rhizoma Chuanxiong 12 by following bulk drugs.For ease of distinguishing, this medicine called after invigorating YANG presses down cloudy soup.

Usual method is fried in shallow oil soup, and potion on the one divides morning, late secondary clothes down.The 15-30 agent is a course of treatment.

The side separates: this phase only needs strengthening vital QI to eliminate pathogenic factors, and Yin Yang balancing is for then.Radix Pseudostellariae, the Radix Astragali, Rhizoma Polygonati, Ganoderma sinense Zhao Xu et Zhang, the strong kidney of Rhizoma Gastrodiae QI invigorating, brain-care, sedate is calmed the nerves, strengthening by means of tonics, inspiring enthusiasm is monarch; Fructus Hordei Germinatus (parched), Rhizoma Atractylodis Macrocephalae preparata is opened spleen and is good for the stomach, and care middle-jiao yang, function of the spleen and stomach is adjuvant drug.Being intended to central hinge, is to close the overall situation, and last sending up the lucid YANG is gone into brain, and the kidney-Yang of receiving is down gone into kidney.Flos Pruni mume, Flos Albiziae, Cortex Albiziae, Radix Bupleuri are minister, soothe the spirit and please meaning, relieve the lonliness and grief and allay sorrow, and resolving depression is held concurrently anti-depressed.Os Draconis, Dens Draconis, Concha Ostreae, tranquillization with heavy prescription and have Guyang not loose the power that YANG hyperactivity suppressing is containing.5 Caulis Polygoni Multiflori nourishing blood to tranquillize the mind add deep sleep with fixed its will again, are adjuvant drug altogether.Rhizoma Chuanxiong makes when being classified as, blood circulation promoting and blood stasis dispelling and tissue regeneration promoting.People's life, QI and blood is for supporting, and the Fu Shengzhu disease is relevant with QI and blood invariably, hereat, the QI and blood people having the same aspiration and interest, female general rules together, and monarch is made curative effect altogether and how to be taken a disease invariably more you.One course of treatment of 15-30 agent, though sickly heal a course of treatment, be not knock off in.Because sick body restores as yet, in case recurrence changed for the 4th step into, continuous using at the medicine of negative initial phase symptom defended tenaciously kidney-Yang soup continuation treatment.

Scheme four, series medicaments for psychosis negative four-step therapy, it is characterized in that, for negative initial phase symptom, be to make: Ganoderma sinense Zhao Xu et Zhang 15, Fructus Schisandrae Chinensis 15, Fructus Lycii 6, Flos Pruni mume 6, Flos Albiziae 15, Cortex Albiziae 15, Radix Polygalae 9, Radix Bupleuri 15, Fructus Mori 15, Rhizoma Polygonati 15, Fructus Ligustri Lucidi 15, the Radix Astragali 15, Semen Cuscutae 10, Rhizoma Chuanxiong 12, Radix Angelicae Sinensis 15, Os Draconis 30, Dens Draconis 20 and Concha Ostreae 25 by following bulk drugs.For ease of distinguishing, this medicine called after is defended tenaciously kidney-Yang soup.

Usual method is fried in shallow oil soup, and potion on the one divides morning, late secondary clothes down.One course of treatment of 15-30 agent.

The side separates: the initial phase symptom, and the negative patient belongs to natural endowment more, and the people of feminine gender claims introvert.Congenital personality defective will need replenish the day after tomorrow, and the yang-energy of body enriches with regard to improving cloudy crossing to be contained.Kidney-Yin kidney-Yang, or say nephroyin and nephroyang, have the kidney being a ZANG-organ containing both water and fire under one's command by kidney.Hereat, this phase only need be replenished kidney yang, and gasification kidney water, water is cold coagulation and cloth profit not, the not scorching and Wen Xun of sun, promptly anti-six evils's invasion, the seven emotions that disappear again civil strike.Fructus Schisandrae Chinensis, Fructus Lycii, Fructus Mori, Semen Cuscutae, Ganoderma sinense Zhao Xu et Zhang, Rhizoma Polygonati, Fructus Ligustri Lucidi, the Radix Astragali are monarch's kidney-replenishing, the kidney qi of receiving in the side, the Fructus Alpiniae Oxyphyllae of calming the nerves, and strengthening by means of tonics is inspired enthusiasm.Flos Pruni mume, Flos Albiziae, Cortex Albiziae, Radix Polygalae, the happy feelings of Radix Bupleuri are pleased meaning, and allaying sorrow is sad, clever brain sedate, and it is minister that accent reaches irritability.Os Draconis, Dens Draconis, Concha Ostreae, for assistant, help the monarch and his subjects' tranquilizing the mind, the perfume (or spice) of the sleeping sweet power of sleeping, the fragrant refreshing peace that is intended to sleep, refreshing peace will is fixed, the will rule is distinguished intelligence, distinguishes that then broken the doubting of intelligence explain the puzzle, and does not have the institute of doubt and is stranded, then brain is clever wakes up, the mind not disorderly, minor illness is from dispelling, and anosisly prevents certainly.Rhizoma Chuanxiong, make when being classified as, the gas medicine in the blood, QI and blood is full of freely, and female handsome healthy, smoothness does not hinder, and takes the sun of all medicines, and drum shakes and does not stop, and the moon is held back sun and is shaken, and life is active, so do not recur after recovering.

This medicine is classified and four-step therapeutics based on psychosis negative, according to different character, and the different stages, to execute and control different medicines, curative effect is sure, and the cure rate height does not have recurrence.

The clinical practice situation of this medicine series:

Adopt single at random blind method to be divided into experimental group and matched group, each 140 example.Experimental group the inventive method, matched group adopts conventional chemical medicine treatment (as using oral clozapine).

The recovery from illness standard is: 1, mental symptom complete obiteration, and particularly original hallucinatory-paranoid syndrome shape disappears, and is emotionally stable, and the volitional behavior aspect is no abnormal.2, insight recovers, promptly patient the morbid state of self is experienced fully realize, judgment; 3, adapt to social environment, recovery social ability, can be competent at sick preceding work, study and work; 4, after the state of an illness returns to above-mentioned level, to keep at least more than two months and just cure at last.

Table one: experimental group treatment situation

Annotate: the severe phase, the patient was in the time of 9 months, had two examples out of touch, not at the row of statistics.

Table two: two groups of recovery from illness numbers compare:

Above experimental result shows: the inventive method medicine series, and to the psychotic positive symptom of thorough radical cure, curative effect is sure, and disease heals invariably.Other difference of state of an illness level just, the course of treatment length difference.If patient and Seek early medical advice, disease is not controlled earlier, just can not develop into moderate and severe.Even moderate, severe patient as long as adhere to being used this method, finally can both thoroughly cure.Changed psychosis and taken medicine throughout one's life, final disabled adverse consequences.Fact proved that the ancient Chinese medicine former worthies say real: the Chinese traditional treatment psychosis " ten give birth to its ten, hundred give birth to its hundred, disease invariably more you ".

For effect of the present invention is described, now provide following model case:

Model case one, negative symptoms severe phase patient.

Pan Zhiyin people from Shanghe County, man, 46 years old.Introverted, vanity is strong, medical history 3 days, teachers training school's graduation.The discovery object is overstepped the limit.Sweet anger dare not be sayed, morbidity gradually.Examined negative schizophrenia in certain province mental hospital in 2005, treated 6 months.Though clothes sulpiride, Wei Sitong medicine effectively and are not healed, the state of an illness is more serious after the drug withdrawal.Came my institute's first visit on March 9th, 2008.The disease meeting is amimia, and yellow skin is simple and unadorned, the whole face dirt, and the hair beard is fluffy and disorderly, wears clothes dirty and not whole.Lower one's head and say no words, expression in the eyes is ineffective.Qiang Wenneng answers, and part is kept to the point, the language dullness.Ask that the household learns, since disease, the friend colleague, tool does not does not come and go, and father and mother brother tool is not got close to.Wife does not strike back when being hit, and does not retort when sworn at.Though snap head off, also unmoved.Do not wash one's face, do not brush teeth.Do not change underwear in 2 years, the back of the body camel of bending over, stride is crooked, and pale tongue with white fur is thick, and corpulent tongue is big, it is unable to loll, and tongue can not stretched lip, and deep pulse is like volt, and is thin and delicate unable, the typical negative symptoms severe phase behind one step of throwing " the excited soup of warming YANG ", 25 doses of medicines, washes one's face and brushes teeth, and more changes one's clothes.Oneself go to the dining room to get food, haircut is shaved, and language increases, the severe transference cure.Probably warming YANG give birth to dry, use second step " YANG invigorating refreshment soup " 30 doses of medicines instead after, go into the street voluntarily and buy newspaper, fruit.Mountain-climbing is played, and the speech happiness is laughed at, talk active, moderate transference cure.Probably YANG invigorating too, use 15 doses of the 3rd slight phases in step " invigorating YANG presses down cloudy soup " instead after, spirit is normal, goes on 15 doses, meets the people and treats thing, reading is read newspaper.Recover the study excitement, and be determined to be back on the job.Be anti-recurrence, correct the natural endowment body of the moon partially, used for the 4th step " defending tenaciously kidney-Yang soup " instead to be apt to thereafter 20 doses of drug withdrawal recoveries from illness.Total courses of treatment 3 wheat harvesting period.Though struggle for a divorce with wife, still there is not the recurrence sign, good so far.

This medicine series is treated negative severe patient's 50 examples, minimal ages 17 years old, maximum 47 years old age, 27 years old mean age, 2 months the shortest courses of treatment, 12 months the longest courses of treatment, average course of treatment 7 months.Adhered to covering four steps, none person of not healing.

Model case two, negative symptoms moderate phase patient.

Wang Changyi, people from Hebei, woman 23 years old, unmarried, big single-minded grade, English Major.Due to illness discontinue one's studies.Introverted unsociable and eccentric, because of learning pressure is big, be at odds with the classmate again.Criticized by teacher, morbidity gradually, medical history 4 years.Lived 3 times in certain province mental hospital, examined negative schizophrenia, sulpiride, clozapine, perphenazine and so on.Beginning effectively stagnated protracted course of disease afterwards.On April 20th, 2005 examined, and disease meeting coloured light is simple and unadorned in vain, and expression in the eyes is dull ineffective, and question and answer are kept to the point, and it is blunt to reply, and tongue is thin, and tongue is white, and deep pulse is unable.Be diagnosed as the moderate negative symptoms, behind second step " YANG invigorating refreshment soup " 30 doses of medicines, active speech increases.Main washing one's face brushed teeth, and washes clothes, and whole bed is seen TV, the program of watching video shows, and energy and TV programme happiness are synchronously laughed at.Probably YANG invigorating too, scorching bright the moon, use 30 doses of the 3rd slight phases in step " invigorating YANG presses down cloudy soup " instead after, withdraw Western medicine, recover normal, the rich reality of expressing one's feelings, expression in the eyes is flexible, and the speech ceremony is refined in manner, action degree of having, life is orderly for preventing recurrence, uses the 4th step " defending tenaciously kidney-Yang soup " 20 doses instead, to be apt to thereafter.Total 2 months 0 20 days course of treatment, thoroughly cure the back and do manual work, dried private tutor earns money, so far not recurrence.

This medicine series is treated negative moderate phase patient 50 examples, minimal ages 16 years old, maximum 45 years old age, 25 years old half mean age, 1 month the shortest course of treatment, 11 months the longest courses of treatment, average course of treatment 6 months.Adhere to covering none person of not healing of patient in three steps.

Model case three negative symptomses are slight phase patient.

Chen Liang show woman, 21 years old, junior college, accounting profession, people from Zhucheng, Weifang, introverted the school freshman, docility, vanity is strong, and is actively eager to learn, learns the good performance show, and because of a total marks of the examination downslide, the state of mind is annoyed, feels not had face.Inferior to others, be reluctant to show up in public, be reluctant to participate in morning exercises, physical training.Poverty of speech, autokinesis reduces, and the friend-making excitement descends, and can not learn lastingly.On August 9th, 2008 examined, and the disease meeting is simple and unadorned in vain, feeling the pulse, two cun chis are heavy and soft, and two close inadequate four to unable, according to main suit's symptom, the disease arteries and veins closes ginseng, echos for the 3rd step, the negative moderate phase, execute by the 3rd step side's medicine " invigorating YANG presses down cloudy soup " and to control 25 doses, transference cure, probably YANG invigorating is too, use the 4th step " defending tenaciously kidney-Yang soup " 20 doses instead, drug withdrawal is gone to school, and achievement rises, so far not recurrence, and introduce 10 years psychiatric histories of its cousin, come to seek medical advice.

Negative slight phase patient patient 20 examples of this medicine series treatment.Minimum 16 years old, maximum 28 years old, 22 years old mean age, 1 month the shortest course of treatment, 3 months the longest courses of treatment, average course of treatment one and a half months, none person of not healing entirely.

Model case four negative symptoms initial phase patients.

Cui Ran, man 21 years old, sophomore, legal profession, introvert.First visit on May 2 in 2005.Many because of reciting problem, learning pressure is big, the positive loss of heart kidney, and the sleep table is shallow, and dreaminess is forgetful.Do not recover from fatigue after sleeping, fatiguability, it is more preceding low to make friends, diet still can, do not have other discomforts.Feeling the pulse cun chi pulse is heavy, unable.The disease arteries and veins closes ginseng, echos the 4th step side's medicine standard.Throw " defending tenaciously kidney-Yang soup " 20 doses.Primary symptom all disappears.The clothes that continue are consolidated curative effect for 10 doses, finish college smoothly.So far employment is good, has stopped psychotic generation.

This medicine series treatment negative symptoms initial phase patient, 20 examples.Minimal ages 18 years old, maximum 30 years old age.24 years old mean age, 20 days the shortest courses of treatment, 40 days the longest courses of treatment, average course of treatment one month.Without sleeping pill, none person of not healing.

For negative symptoms initial phase and slight phase patient, initiatively the hospitalier seldom, majority develops into the moderate phase and just seeks medical advice, though because initial phase and slight phase symptom occurs as insomnia, the sleep table is shallow, uncomfortable, is that majority are tired nervous, the normal problem that occurs.As not noting social activity, friend-making interest descends, and autokinesis reduces, the language content poorness.This is the ubiquitous problem of introvert, also is introvert people's consistent performance.Though with a difference is preceding arranged, not clearly, out in the cold mostly.As for work and study can not be lastingly this be only the most obvious, this symptom that arouses attention because adhere to study, durable work, to people's person's character, running counter to person's character is exactly disease in being only., the appearance of this symptom, again with usual fatigue after reacting phase approximate.So, be subjected to general ignorance equally.It does not know that this is the symbol that disease takes place silently.How this class patient does not seek medical advice, and sees a doctor exactly and neither at first go psychiatric department.And lose other polyclinics.Looking under the situation of not having other corresponding signs, again by " anosis release ".If come here to seek medical advice, according to existing symptom, switch to two cun chi pulses resemble heavy and soft, two close chi pulses inadequate four to and unable, according to above symptom, can make a definite diagnosis errorless.Execute by the three-four step side's medicine and to control the 20-30 agent and can fully recover, can stop to develop into the possibility of negative Split disease thus fully.What the 4th step negative symptoms initial phase " was defended tenaciously kidney-Yang soup " is also advantageous in that, has no side effect, for a long time the no fraud of clothes; Initial phase 10-20 agent recovery from illness prevents to develop psychotic possibility; For the people of negative personality, clothes 10-15 agent can prevent primary disease to take place before per season.

The specific embodiment

At four kinds of primary symptoms of psychosis negative: the flat affect or blunt, the poverty of thought, aboulia, attention deficit disorder.

Series medicaments for psychosis negative four-step therapy:

One step of severe phase medicine	Two step of moderate phase medicine	Slight three step of phase medicine	Four step of initial phase medicine
				The excited soup of warming YANG: form: (g) Radix Ginseng 15, Ganoderma sinense Zhao Xu et Zhang 15, Rhizoma Gastrodiae 15, Cortex Magnoliae Officinalis 10, Flos Pruni mume 6, Flos Albiziae 20, Rhizoma Chuanxiong 12, Radix Angelicae Sinensis 15, Rhizoma Atractylodis Macrocephalae preparata 15, Fructus Hordei Germinatus (parched to brown) 10, Fructus Crataegi (parched to brown) 10, Massa Medicata Fermentata (parched to brown) 10, Rhizoma Anemones Altaicae 12, Cortex Cinnamomi 10, Ramulus Cinnamomi 15, the Radix Astragali 20 and Rhizoma Zingiberis 6, decoction; Lignum Aquilariae Resinatum 1.5, Cornu Cervi Pantotrichum 1.5 and Aspongopus 1.5 are ground into powder and take after mixing it with water.Every day potion, early, late secondary clothes down.One course of treatment of 15-30 agent.	YANG invigorating refreshment soup: form: (g) Radix Ginseng 15, Ganoderma sinense Zhao Xu et Zhang 15, Rhizoma Gastrodiae 15, Cortex Magnoliae Officinalis 10, Flos Pruni mume 6, Flos Albiziae 20, Rhizoma Chuanxiong 12, Radix Angelicae Sinensis 15, Rhizoma Atractylodis Macrocephalae preparata 15, Fructus Hordei Germinatus (parched to brown) 10, Fructus Crataegi (parched to brown) 10, Massa Medicata Fermentata (parched to brown) 10 and Rhizoma Anemones Altaicae 12, decoction, Lignum Aquilariae Resinatum 1.5, Cornu Cervi Pantotrichum 1.5 and Aspongopus 1.5 are ground into powder and take after mixing it with water.Every day potion, early, late secondary clothes down.30 dose of one course of treatment of 15-.	Invigorating YANG presses down cloudy soup: form: (g) Radix Pseudostellariae 15, Ganoderma sinense Zhao Xu et Zhang 10, Rhizoma Gastrodiae 15, the Radix Astragali 15, Rhizoma Polygonati 15, Fructus Hordei Germinatus (parched) 12, Rhizoma Atractylodis Macrocephalae preparata 12, Flos Pruni mume 5, Flos Albiziae 15, Cortex Albiziae 15, Radix Bupleuri 15, Os Draconis 30, Dens Draconis 20, Concha Ostreae 20, Caulis Polygoni Multiflori 15, Radix Angelicae Sinensis 15 and Rhizoma Chuanxiong 12; Usual method decocting soup, every day potion, early, late secondary clothes down.30 dose of one course of treatment of 15-.	Defend tenaciously kidney-Yang soup: form: (g) Ganoderma sinense Zhao Xu et Zhang 15, Fructus Schisandrae Chinensis 15, Fructus Lycii 6, Flos Pruni mume 6, Flos Albiziae 15, Cortex Albiziae 15, Radix Polygalae 9, Radix Bupleuri 15, Fructus Mori 15, Rhizoma Polygonati 15, Fructus Ligustri Lucidi 15, the Radix Astragali 15, Semen Cuscutae 10, Rhizoma Chuanxiong 12, Radix Angelicae Sinensis 15, Os Draconis 30, Dens Draconis 20 and Concha Ostreae 25. usual method decocting soup, every day potion, early, late secondary clothes down.One course of treatment of 15-30 agent.

For meeting the psychosis negative initial phase, impose and defend tenaciously kidney-Yang soup, only do negative the 4th step treatment.

For meeting the slight phase of psychosis negative, impose invigorating YANG and press down cloudy soup, do negative the 3rd step treatment, reach after the 3rd step therapeutic purposes the 4th step treatment of turning out cloudy property and impose and defend tenaciously kidney-Yang soup, to more.

For meeting the psychosis negative moderate phase, impose YANG invigorating refreshment soup, do negative second step treatment, reach turning out cloudy property the 3rd step treatment after the second step therapeutic purposes, through negative the 4th step, to more.

For meeting the psychosis negative severe phase, impose the excited soup of warming YANG, do negative first step treatment, reach second step of turning out cloudy property after the first step therapeutic purposes, the treatment of the 3rd, the 4th step, to more.

The present invention also can cooperate Western medicine and psychotherapy, and effect is better.

Claims (4)

1, series medicaments for psychosis negative four-step therapy, it is characterized in that, for negative initial phase symptom, be to make: Ganoderma sinense Zhao Xu et Zhang 15, Fructus Schisandrae Chinensis 15, Fructus Lycii 6, Flos Pruni mume 6, Flos Albiziae 15, Cortex Albiziae 15, Radix Polygalae 9, Radix Bupleuri 15, Fructus Mori 15, Rhizoma Polygonati 15, Fructus Ligustri Lucidi 15, the Radix Astragali 15, Semen Cuscutae 10, Rhizoma Chuanxiong 12, Radix Angelicae Sinensis 15, Os Draconis 30, Dens Draconis 20 and Concha Ostreae 25, decoction by following bulk drugs.

2, series medicaments for psychosis negative four-step therapy according to claim 1, it is characterized in that, for the slight phase symptom of feminine gender, also comprise by following bulk drugs and making: Radix Pseudostellariae 15, Ganoderma sinense Zhao Xu et Zhang 10, Rhizoma Gastrodiae 15, the Radix Astragali 15, Rhizoma Polygonati 15, Fructus Hordei Germinatus (parched) 12, Rhizoma Atractylodis Macrocephalae preparata 12, Flos Pruni mume 5, Flos Albiziae 15, Cortex Albiziae 15, Radix Bupleuri 15, Os Draconis 30, Dens Draconis 20, Concha Ostreae 20, Caulis Polygoni Multiflori 15, Radix Angelicae Sinensis 15 and Rhizoma Chuanxiong 12; Decoction.

3, series medicaments for psychosis negative four-step therapy according to claim 2, it is characterized in that, for negative moderate phase symptom, also comprise by following bulk drugs and making: Radix Ginseng 15, Ganoderma sinense Zhao Xu et Zhang 15, Rhizoma Gastrodiae 15, Cortex Magnoliae Officinalis 10, Flos Pruni mume 6, Flos Albiziae 20, Rhizoma Chuanxiong 12, Radix Angelicae Sinensis 15, Rhizoma Atractylodis Macrocephalae preparata 15, Fructus Hordei Germinatus (parched to brown) 10, Fructus Crataegi (parched to brown) 10, Massa Medicata Fermentata (parched to brown) 10 and Rhizoma Anemones Altaicae 12, decoction; Lignum Aquilariae Resinatum 1.5, Cornu Cervi Pantotrichum 1.5 and Aspongopus 1.5 are ground into powder and take after mixing it with water.

4, series medicaments for psychosis negative four-step therapy according to claim 3, it is characterized in that, for negative severe phase symptom, also comprise by following bulk drugs and making: Radix Ginseng 15, Ganoderma sinense Zhao Xu et Zhang 15, Rhizoma Gastrodiae 15, Cortex Magnoliae Officinalis 10, Flos Pruni mume 6, Flos Albiziae 20, Rhizoma Chuanxiong 12, Radix Angelicae Sinensis 15, Rhizoma Atractylodis Macrocephalae preparata 15, Fructus Hordei Germinatus (parched to brown) 10, Fructus Crataegi (parched to brown) 10, Massa Medicata Fermentata (parched to brown) 10, Rhizoma Anemones Altaicae 12, Cortex Cinnamomi 10, Ramulus Cinnamomi 15, the Radix Astragali 20 and Rhizoma Zingiberis 6, decoction; Lignum Aquilariae Resinatum 1.5, Cornu Cervi Pantotrichum 1.5 and Aspongopus 1.5 are ground into powder and take after mixing it with water.