CN101553500B - Gnrh(促性腺激素释放激素)肽衍生物 - Google Patents

Gnrh(促性腺激素释放激素)肽衍生物 Download PDF

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Publication number
CN101553500B
CN101553500B CN200780026537.3A CN200780026537A CN101553500B CN 101553500 B CN101553500 B CN 101553500B CN 200780026537 A CN200780026537 A CN 200780026537A CN 101553500 B CN101553500 B CN 101553500B
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China
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gnrh
ltrp
lhis
cells
plglu
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Expired - Fee Related
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English (en)
Chinese (zh)
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CN101553500A (zh
Inventor
R·P·米勒
S·R·莫兹利
R·洛佩斯德马图拉纳加门迪亚
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Medical Research Council
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Medical Research Council
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN200780026537.3A 2006-06-16 2007-05-01 Gnrh(促性腺激素释放激素)肽衍生物 Expired - Fee Related CN101553500B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201210447203.6A CN102977188B (zh) 2006-06-16 2007-05-01 Gnrh(促性腺激素释放激素)肽衍生物

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US80504206P 2006-06-16 2006-06-16
US60/805,042 2006-06-16
US80518106P 2006-06-19 2006-06-19
US60/805,181 2006-06-19
GB0616111.1 2006-08-12
GBGB0616111.1A GB0616111D0 (en) 2006-06-16 2006-08-12 Agents, methods and uses
PCT/GB2007/001586 WO2007144554A2 (en) 2006-06-16 2007-05-01 Gnrh (gonadotropin-releasing hormone) peptide variants
US12/308,482 US9388216B2 (en) 2006-06-16 2007-05-01 Methods of treating reproductive cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201210447203.6A Division CN102977188B (zh) 2006-06-16 2007-05-01 Gnrh(促性腺激素释放激素)肽衍生物

Publications (2)

Publication Number Publication Date
CN101553500A CN101553500A (zh) 2009-10-07
CN101553500B true CN101553500B (zh) 2014-01-01

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ID=38626706

Family Applications (2)

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CN200780026537.3A Expired - Fee Related CN101553500B (zh) 2006-06-16 2007-05-01 Gnrh(促性腺激素释放激素)肽衍生物
CN201210447203.6A Expired - Fee Related CN102977188B (zh) 2006-06-16 2007-05-01 Gnrh(促性腺激素释放激素)肽衍生物

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CN201210447203.6A Expired - Fee Related CN102977188B (zh) 2006-06-16 2007-05-01 Gnrh(促性腺激素释放激素)肽衍生物

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Country Link
US (1) US9388216B2 (https=)
EP (1) EP2029618B1 (https=)
JP (2) JP5290163B2 (https=)
CN (2) CN101553500B (https=)
GB (1) GB0616111D0 (https=)
WO (1) WO2007144554A2 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101864398B (zh) * 2009-09-03 2012-11-14 李吉祐 一种抗促性腺激素释放激素受体的单克隆抗体与应用
US20120004182A1 (en) * 2010-07-02 2012-01-05 Carsten Gruendker Pharmaceutical compositions and methods for induction and enhancement of apoptosis in tumor cells
EP2447276A1 (en) * 2010-10-27 2012-05-02 Ferring B.V. Process for the manufacture of Degarelix and its intermediates
CN102675420B (zh) * 2011-03-17 2014-08-27 屏东科技大学 一种促进鱼类卵黄生成的合成胜肽及其用途
CN108524919A (zh) 2012-05-17 2018-09-14 延伸生物科学股份有限公司 用于改进的药物递送的载体
US9789197B2 (en) 2014-10-22 2017-10-17 Extend Biosciences, Inc. RNAi vitamin D conjugates
US9585934B2 (en) 2014-10-22 2017-03-07 Extend Biosciences, Inc. Therapeutic vitamin D conjugates
WO2016065052A1 (en) 2014-10-22 2016-04-28 Extend Biosciences, Inc. Insulin vitamin d conjugates
US9526768B2 (en) 2014-11-13 2016-12-27 Jennifer Mai Compositions for the treatment of cancer
AU2018209239B2 (en) * 2017-01-20 2023-02-02 ISR Immune System Regulation Holding AB (publ) Novel compounds (immunorhelins- intracellular infections)
CN110381977A (zh) 2017-01-20 2019-10-25 免疫系统调节控股有限公司 已知化合物的治疗细胞内感染的新用途
EP3571213A1 (en) 2017-01-20 2019-11-27 Immune System Regulation Holding AB Novel compounds (immunorhelins)
WO2018153961A1 (en) 2017-02-22 2018-08-30 Immune System Regulation Holding Ab Gonadotropin-releasing hormones for use as adjuvant immunotherapeutics
CN107995138B (zh) * 2017-12-29 2020-10-23 中国电子科技集团公司第二十研究所 Sccpm系统的联合迭代载波同步与解调方法
CN111875673B (zh) * 2020-07-31 2022-03-11 江苏莱森生物科技研究院有限公司 一种具有抗肿瘤活性的多肽及其用途
CN115326937B (zh) * 2021-05-11 2024-06-18 山东省食品药品检验研究院 一种基因毒杂质捕捉用固相探针及其使用方法与应用
EP4593867A2 (en) 2022-09-30 2025-08-06 Extend Biosciences, Inc. Long-acting parathyroid hormone

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1179181A (zh) * 1995-02-10 1998-04-15 萨斯喀彻温大学 GnRH－白细胞毒素嵌合体
CN1200674A (zh) * 1994-07-22 1998-12-02 汉普顿路医学院 为长期治疗方案确立基础(tonic)卵巢雌激素分泌

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2029018A1 (en) 1989-11-01 1991-05-02 Robert P. Millar Analogues of gonadotropin releasing hormone
US6664369B1 (en) 1994-08-10 2003-12-16 Creighton University GnRH analogues with antitumour effects and pharmaceutical compositions thereof
CA2264562C (en) 1996-08-30 2012-01-03 Peptech Limited Sustained peptide-release formulation
GB2343182A (en) 1998-10-27 2000-05-03 Ferring Bv Use of GnRH-II and analogues thereof for the treatment of osteoporosis
GB2344287A (en) 1998-12-03 2000-06-07 Ferring Bv Controlled release pharmaceutical formulation
US6323179B1 (en) 1999-10-15 2001-11-27 Theresa Siler-Khodr Chicken GNRH analogs and uses thereof in regulation of fertility and pregnancy
US7109171B2 (en) 2000-02-28 2006-09-19 Praecis Pharmaceuticals Inc. Methods for treating FSH related conditions with GnRH antagonists
US7834141B1 (en) 2000-03-31 2010-11-16 Theresa Siler-Khodr Non-mammalian GnRH analogs and uses thereof in tumor cell growth regulation and cancer therapy
US20040152639A1 (en) 2001-08-28 2004-08-05 Siler-Khodr Theresa M. Non-mammalian GnRH analogs and uses thereof in regulation of fertility and pregnancy
AU2003210062A1 (en) 2002-05-03 2003-11-17 Hyuk-Bang Kwon Agonists and antagonists of gonadotropin-releasing hormone-2, and use thereof
ES2259418T3 (es) * 2002-07-22 2006-10-01 Ardana Bioscience Limited Metodo de deteccion sistematica y farmaco candidato antitumor.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1200674A (zh) * 1994-07-22 1998-12-02 汉普顿路医学院 为长期治疗方案确立基础(tonic)卵巢雌激素分泌
CN1179181A (zh) * 1995-02-10 1998-04-15 萨斯喀彻温大学 GnRH－白细胞毒素嵌合体

Also Published As

Publication number Publication date
EP2029618B1 (en) 2015-08-12
JP5290163B2 (ja) 2013-09-18
CN102977188A (zh) 2013-03-20
US9388216B2 (en) 2016-07-12
WO2007144554A2 (en) 2007-12-21
JP2009539952A (ja) 2009-11-19
WO2007144554A3 (en) 2008-02-14
GB0616111D0 (en) 2006-09-20
CN102977188B (zh) 2015-07-15
JP2013056883A (ja) 2013-03-28
CN101553500A (zh) 2009-10-07
US20100234303A1 (en) 2010-09-16
EP2029618A2 (en) 2009-03-04

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