CN101534648B - 使用mntf肽及其类似物治疗神经紊乱的方法 - Google Patents

使用mntf肽及其类似物治疗神经紊乱的方法 Download PDF

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Publication number
CN101534648B
CN101534648B CN2007800419244A CN200780041924A CN101534648B CN 101534648 B CN101534648 B CN 101534648B CN 2007800419244 A CN2007800419244 A CN 2007800419244A CN 200780041924 A CN200780041924 A CN 200780041924A CN 101534648 B CN101534648 B CN 101534648B
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China
Prior art keywords
mntf
peptide
mice
animals
disease
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Expired - Fee Related
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CN2007800419244A
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English (en)
Chinese (zh)
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CN101534648A (zh
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P-Y·D·寇
M·S·金迪
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Genervon Biopharmaceuticals LLC
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Genervon Biopharmaceuticals LLC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN2007800419244A 2006-11-10 2007-11-13 使用mntf肽及其类似物治疗神经紊乱的方法 Expired - Fee Related CN101534648B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US85802206P 2006-11-10 2006-11-10
US60/858,022 2006-11-10
PCT/US2007/023951 WO2008057609A2 (en) 2006-11-10 2007-11-13 Methods of treating neuronal disorders using mntf peptides and analogs thereof

Publications (2)

Publication Number Publication Date
CN101534648A CN101534648A (zh) 2009-09-16
CN101534648B true CN101534648B (zh) 2013-12-11

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Family Applications (1)

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CN2007800419244A Expired - Fee Related CN101534648B (zh) 2006-11-10 2007-11-13 使用mntf肽及其类似物治疗神经紊乱的方法

Country Status (9)

Country Link
US (1) US8673852B2 (cg-RX-API-DMAC10.html)
EP (1) EP2086331B1 (cg-RX-API-DMAC10.html)
JP (1) JP5336384B2 (cg-RX-API-DMAC10.html)
CN (1) CN101534648B (cg-RX-API-DMAC10.html)
AU (1) AU2007317730B2 (cg-RX-API-DMAC10.html)
CA (1) CA2669658C (cg-RX-API-DMAC10.html)
DK (1) DK2086331T3 (cg-RX-API-DMAC10.html)
ES (1) ES2407454T3 (cg-RX-API-DMAC10.html)
WO (1) WO2008057609A2 (cg-RX-API-DMAC10.html)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8846615B2 (en) * 2008-02-21 2014-09-30 Genervon Biopharmaceuticals, LLC MNTF peptides
RU2012123642A (ru) * 2009-12-11 2014-01-20 Кейз Вестерн Ризев Юнивесити Аналоги инсулина, содержащие хлорированные аминокислоты
GB201015569D0 (en) * 2010-09-16 2010-10-27 Medical Res Council Blood assay for prions
WO2016210123A1 (en) 2015-06-26 2016-12-29 Genervon Biopharmaceuticals, LLC Methods of using gm604 in modulating als disease biomarkers leading to prognosis and therapeutic treatment for als disease
WO2018119018A1 (en) * 2016-12-23 2018-06-28 Genervon Biopharmaceuticals, LLC Methods of using gm6 in diagnosing and treating alzheimer's disease
WO2018129421A1 (en) * 2017-01-09 2018-07-12 Genervon Biopharmaceuticals, LLC A promising drug candidate for parkinson's disease
AU2019277920A1 (en) * 2018-05-31 2021-01-07 Immunity Pharma Ltd. Compositions and methods of using same for treating amyotrophic lateral sclerosis (ALS)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6309877B1 (en) * 1996-09-27 2001-10-30 Km Biotech, Inc. Polynucleotides encoding motoneuronotrophic factors
US6841531B2 (en) * 1996-09-27 2005-01-11 Genervon Biopharmaceuticals Llc Methods and use of motoneuronotrophic factors
WO2004065410A2 (en) * 2003-01-21 2004-08-05 Genervon Biopharmaceuticals Llc Mntf peptides and compositions and methods of use

Also Published As

Publication number Publication date
EP2086331A4 (en) 2010-08-25
ES2407454T3 (es) 2013-06-12
CN101534648A (zh) 2009-09-16
WO2008057609A3 (en) 2008-12-18
WO2008057609A8 (en) 2008-08-28
AU2007317730A1 (en) 2008-05-15
JP5336384B2 (ja) 2013-11-06
CA2669658A1 (en) 2008-05-15
JP2010509345A (ja) 2010-03-25
HK1137623A1 (en) 2010-08-06
WO2008057609A4 (en) 2009-01-29
EP2086331A2 (en) 2009-08-12
CA2669658C (en) 2017-12-12
WO2008057609A2 (en) 2008-05-15
US20090048162A1 (en) 2009-02-19
AU2007317730B2 (en) 2014-01-09
EP2086331B1 (en) 2013-03-27
DK2086331T3 (da) 2013-05-27
US8673852B2 (en) 2014-03-18

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