CN101524561A - Cap-shaped contraceptive gel preparation - Google Patents
Cap-shaped contraceptive gel preparation Download PDFInfo
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- CN101524561A CN101524561A CN200810084904A CN200810084904A CN101524561A CN 101524561 A CN101524561 A CN 101524561A CN 200810084904 A CN200810084904 A CN 200810084904A CN 200810084904 A CN200810084904 A CN 200810084904A CN 101524561 A CN101524561 A CN 101524561A
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- preparation
- gel
- gel preparation
- hat
- contraceptive
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Abstract
The invention relates to a cap-shaped contraceptive gel preparation, which is compounded by carboxymethylcellulose sodium and other gels. The cap-shaped contraceptive gel preparation has the advantages that: 1, the preparation can rapidly absorb water (tissue fluid) in cervical ostium, is expanded and dissolved, and generates biological adhesion which is firmly adhered on the cervical ostium and covers the cervical ostium to achieve the aim of contraception; 2, after the gel entering cervix is dissolved, a protective layer with high gel viscosity is formed in the cervical ostium to deactivate sperm so as to achieve the effect of contraception; 3, the preparation can be biodegraded in a human body and has no residue and no toxic and side effects; and 4, the preparation is convenient to use and easy to be accepted by a user.
Description
Technical field
The present invention relates to a kind ofly be composited the hat gel preparation of practising contraception with sodium carboxymethyl cellulose and other gel.
Background technology
At present, method of contraception consists essentially of: condom, contraceptive diaphragm, oral contraceptive, spermicide etc.Condom can bring both sides' sense of discomfort, and contraceptive diaphragm easily comes off, and causes the danger of becoming pregnant, and oral contraceptive, spermicide can bring side effect to health.
Summary of the invention
In order to overcome the deficiency that condom, contraceptive diaphragm, oral contraceptive, spermicide have side effects, the invention provides a kind of gel preparation that is composited with sodium carboxymethyl cellulose and other gel.
Described sodium carboxymethyl cellulose accounts for the weight of this suppository 0.1%～60%.
Described gel is: the mixture of one or more in carbomer, methylcellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose, hydroxypropyl emthylcellulose, carboxymethyl starch sodium, sodium alginate, trehalose, chitosan, hyaluronate sodium, Polyethylene Glycol, polyvinyl alcohol, polyvinylpyrrolidone, maltodextrin, pulullan polysaccharide, arabic gum, locust bean gum, pectin, Konjac glucomannan, guar gum, POLY-karaya, xanthan gum, carrageenan, agar, the gelatin.
Described preparation be shaped as hat.
The technical solution adopted for the present invention to solve the technical problems is:
1. at first, sodium carboxymethyl cellulose and other one or more gels are mixed in proportion;
2. proper amount of deionized water, glycerol, tween 80 are added in 1., under 50 ℃～90 ℃ temperature, stir, make the gel paste raw materials;
3. treat to pass through when paste raw materials 2. temperature are reduced to 45 ℃ die forming;
4. after cooling, solidifying, make the contraceptive gel preparation of hat.
The invention has the beneficial effects as follows: 1. preparation can absorb water (tissue fluid) expansion dissolving rapidly at the orifice of uterus place, produces bioadhesive, firmly adheres to orifice of uterus, and covers in orifice of uterus, reaches the contraception purpose; 2. after entering the gel dissolving at cervix uteri place, in orifice of uterus, form the high protective layer of gel viscosity, thereby sperm is lost vigor and reach contraceptive effect; 3. preparation in vivo can biodegradation, noresidue and toxic and side effects; 4. easy to use, easily accepted by user.
Description of drawings
The present invention is described further below in conjunction with drawings and Examples:
Among the figure: 1. Bi Yun gel preparation front view, 2. the contraception the gel preparation vertical view.
The specific embodiment
Embodiment 1:
In the gel preparation of 1000g contraception:
(1) with 580g sodium carboxymethyl cellulose, 300g polyvinyl alcohol mix homogeneously;
(2) 100g glycerol, 20g tween 80,2000ml deionized water are added in (1), under 50 ℃～90 ℃ temperature, stir, make the gel paste raw materials;
When (3) treating that material temperature is reduced to 45 ℃, pass through die forming;
(4) after cooling, solidifying, make the contraceptive gel preparation of hat.
Embodiment 2:
In the gel preparation of 1000g contraception:
(1) with 500g sodium carboxymethyl cellulose, 80g carboxymethyl starch sodium, 300g polyvinyl alcohol mix homogeneously;
(2) 100g glycerol, 20g tween 80,2000ml deionized water are added in (1), under 50 ℃～90 ℃ temperature, stir, make the gel paste raw materials;
When (3) treating that material temperature is reduced to 45 ℃, pass through die forming;
(4) after cooling, solidifying, make the contraceptive gel preparation of hat.
Embodiment 3:
In the gel preparation of 1000g contraception:
(1) with 500g sodium carboxymethyl cellulose, 80g chitosan, 300g polyvinyl alcohol mix homogeneously;
(2) 100g glycerol, 20g tween 80,2000ml deionized water are added in (1), under 50 ℃～90 ℃ temperature, stir, make the gel paste raw materials;
When (3) treating that material temperature is reduced to 45 ℃, pass through die forming;
(4) after cooling, solidifying, make the contraceptive gel preparation of hat.
Claims (5)
1. the contraceptive gel preparation of a hat contains sodium carboxymethyl cellulose.
2. the contraceptive gel preparation of a hat contains sodium carboxymethyl cellulose and other gel is composited.
3. the contraceptive gel preparation of hat according to claim 1, it is characterized in that: carboxymethyl cellulose accounts for the weight of this unguentum 0.1%～60%.
4. the contraceptive gel preparation of hat according to claim 1 is characterized in that: preparation be shaped as hat.
5. the contraceptive gel preparation of hat according to claim 2, it is characterized in that: other gel is: the mixture of one or more in carbomer, methylcellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose, hydroxypropyl emthylcellulose, carboxymethyl starch sodium, sodium alginate, trehalose, chitosan, hyaluronate sodium, Polyethylene Glycol, polyvinyl alcohol, polyvinylpyrrolidone, maltodextrin, pulullan polysaccharide, arabic gum, locust bean gum, pectin, Konjac glucomannan, guar gum, POLY-karaya, xanthan gum, carrageenan, agar, the gelatin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810084904A CN101524561A (en) | 2008-03-07 | 2008-03-07 | Cap-shaped contraceptive gel preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810084904A CN101524561A (en) | 2008-03-07 | 2008-03-07 | Cap-shaped contraceptive gel preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101524561A true CN101524561A (en) | 2009-09-09 |
Family
ID=41092727
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200810084904A Pending CN101524561A (en) | 2008-03-07 | 2008-03-07 | Cap-shaped contraceptive gel preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101524561A (en) |
-
2008
- 2008-03-07 CN CN200810084904A patent/CN101524561A/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| DD01 | Delivery of document by public notice |
Addressee: Dalian Yongxing Pharma Incubator Co., Ltd. Teng Xishan Document name: Notification that Application Deemed to be Withdrawn |
|
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20090909 |