CN101519401B - Intermediate (S)-2-(2-thiophene ethylamine)(2-chlorphenyl)methyl acetate of clopidogrel and method for preparing salts thereof - Google Patents
Intermediate (S)-2-(2-thiophene ethylamine)(2-chlorphenyl)methyl acetate of clopidogrel and method for preparing salts thereof Download PDFInfo
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- CN101519401B CN101519401B CN 200810033932 CN200810033932A CN101519401B CN 101519401 B CN101519401 B CN 101519401B CN 200810033932 CN200810033932 CN 200810033932 CN 200810033932 A CN200810033932 A CN 200810033932A CN 101519401 B CN101519401 B CN 101519401B
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- thiophene
- para
- methyl ester
- tartrate
- acid
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- 0 COC(C(c1ccccc1Cl)N)=* Chemical compound COC(C(c1ccccc1Cl)N)=* 0.000 description 4
- UTWOZNRDJNWTPS-UHFFFAOYSA-N COC(C(c(cccc1)c1Cl)N)=O Chemical compound COC(C(c(cccc1)c1Cl)N)=O UTWOZNRDJNWTPS-UHFFFAOYSA-N 0.000 description 1
- LMIZLNPFTRQPSF-UHFFFAOYSA-N NC(C(O)=O)c1ccccc1Cl Chemical compound NC(C(O)=O)c1ccccc1Cl LMIZLNPFTRQPSF-UHFFFAOYSA-N 0.000 description 1
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- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
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Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN 200810033932 CN101519401B (en) | 2008-02-27 | 2008-02-27 | Intermediate (S)-2-(2-thiophene ethylamine)(2-chlorphenyl)methyl acetate of clopidogrel and method for preparing salts thereof |
Applications Claiming Priority (1)
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CN 200810033932 CN101519401B (en) | 2008-02-27 | 2008-02-27 | Intermediate (S)-2-(2-thiophene ethylamine)(2-chlorphenyl)methyl acetate of clopidogrel and method for preparing salts thereof |
Publications (2)
Publication Number | Publication Date |
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CN101519401A CN101519401A (en) | 2009-09-02 |
CN101519401B true CN101519401B (en) | 2012-12-05 |
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CN 200810033932 Active CN101519401B (en) | 2008-02-27 | 2008-02-27 | Intermediate (S)-2-(2-thiophene ethylamine)(2-chlorphenyl)methyl acetate of clopidogrel and method for preparing salts thereof |
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CN (1) | CN101519401B (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103172527A (en) * | 2011-12-26 | 2013-06-26 | 湖北德洲科技发展有限公司 | Method for preparing clopidogrel synthetic intermediate-L-2-chlorophenylglycine methyl ester |
CN103980288A (en) * | 2014-06-03 | 2014-08-13 | 成都医路康医学技术服务有限公司 | Production process of clopidogrel |
CN110862372B (en) * | 2019-12-03 | 2024-01-12 | 江西川奇药业有限公司 | Synthesis of clopidogrel intermediate (S) -2- (2-thiophenoethylamine) - (2-chlorophenyl) -methyl acetate |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100999525A (en) * | 2006-10-18 | 2007-07-18 | 深圳信立泰药业有限公司 | Preparation process of clopidogre and its salt |
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- 2008-02-27 CN CN 200810033932 patent/CN101519401B/en active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN100999525A (en) * | 2006-10-18 | 2007-07-18 | 深圳信立泰药业有限公司 | Preparation process of clopidogre and its salt |
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CN101519401A (en) | 2009-09-02 |
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Legal Events
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C06 | Publication | ||
PB01 | Publication | ||
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20090902 Assignee: Jiangsu Baju Pharmaceutical Co., Ltd. Assignor: East China University of Science and Technology|Shanghai Huali biopharmaceutical Co Ltd Contract record no.: 2014320000198 Denomination of invention: Preparation of clopidogrel intermediate (S) -2- (2- thiophene) (2- chloro) methyl acetate and its salts Granted publication date: 20121205 License type: Exclusive License Record date: 20140311 |
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LICC | Enforcement, change and cancellation of record of contracts on the licence for exploitation of a patent or utility model | ||
CP01 | Change in the name or title of a patent holder | ||
CP01 | Change in the name or title of a patent holder |
Address after: 200231 four floor, block B, 18 lane, 1305 lane, Huajing Road, Shanghai. Co-patentee after: East China University of Science and Technology Patentee after: Shanghai Huali bio medicine Limited by Share Ltd Address before: 200231 four floor, block B, 18 lane, 1305 lane, Huajing Road, Shanghai. Co-patentee before: East China University of Science and Technology Patentee before: Shanghai Huali Biopharmaceutical Co., Ltd. |