CN101503408B - 8-[3-氨基-哌啶-1-基]-黄嘌呤化合物 - Google Patents

8-[3-氨基-哌啶-1-基]-黄嘌呤化合物 Download PDF

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Publication number
CN101503408B
CN101503408B CN2009101274493A CN200910127449A CN101503408B CN 101503408 B CN101503408 B CN 101503408B CN 2009101274493 A CN2009101274493 A CN 2009101274493A CN 200910127449 A CN200910127449 A CN 200910127449A CN 101503408 B CN101503408 B CN 101503408B
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China
Prior art keywords
methyl
amino
xanthine
butyne
esi
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Expired - Lifetime
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CN2009101274493A
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English (en)
Chinese (zh)
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CN101503408A (zh
Inventor
弗兰克·希梅尔斯巴赫
埃尔克·兰格科普夫
马赛厄斯·埃克哈特
迈克尔·马克
罗兰·梅尔
拉尔夫·R·H·洛茨
莫哈迈德·塔达约恩
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Boehringer Ingelheim International GmbH
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Boehringer Ingelheim Pharma GmbH and Co KG
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Priority claimed from DE10312353A external-priority patent/DE10312353A1/de
Application filed by Boehringer Ingelheim Pharma GmbH and Co KG filed Critical Boehringer Ingelheim Pharma GmbH and Co KG
Publication of CN101503408A publication Critical patent/CN101503408A/zh
Application granted granted Critical
Publication of CN101503408B publication Critical patent/CN101503408B/zh
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Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
CN2009101274493A 2002-08-21 2003-08-18 8-[3-氨基-哌啶-1-基]-黄嘌呤化合物 Expired - Lifetime CN101503408B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10238243A DE10238243A1 (de) 2002-08-21 2002-08-21 8-[3-Amino-piperidin-1-yl]-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
DE10238243.3 2002-08-21
DE10312353A DE10312353A1 (de) 2003-03-20 2003-03-20 8-[3-Amino-piperidin-1-yl]-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
DE10312353.9 2003-03-20

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNB03819760XA Division CN100522962C (zh) 2002-08-21 2003-08-18 8-[3-氨基-哌啶-1-基]-黄嘌呤,其制备方法及作为药物制剂的用途

Publications (2)

Publication Number Publication Date
CN101503408A CN101503408A (zh) 2009-08-12
CN101503408B true CN101503408B (zh) 2013-04-24

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CN200910127450.6A Expired - Lifetime CN101503409B (zh) 2002-08-21 2003-08-18 8-[3-氨基-哌啶-1-基]-黄嘌呤，其制备方法及作为药物制剂的用途
CN2009101274493A Expired - Lifetime CN101503408B (zh) 2002-08-21 2003-08-18 8-[3-氨基-哌啶-1-基]-黄嘌呤化合物

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Country Status (4)

Country Link
CN (2) CN101503409B (de)
DE (1) DE10238243A1 (de)
UA (1) UA97468C2 (de)
ZA (1) ZA200500087B (de)

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DE102005035891A1 (de) 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
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AR074990A1 (es) 2009-01-07 2011-03-02 Boehringer Ingelheim Int Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
AR075204A1 (es) * 2009-01-29 2011-03-16 Boehringer Ingelheim Int Inhibidores de dpp-4 y composiciones farmaceuticas que los comprenden, utiles para tratar enfermedades metabolicas en pacientes pediatricos, particularmente diabetes mellitus tipo 2
AR077642A1 (es) 2009-07-09 2011-09-14 Arena Pharm Inc Moduladores del metabolismo y el tratamiento de trastornos relacionados con el mismo
EA034869B1 (ru) 2009-11-27 2020-03-31 Бёрингер Ингельхайм Интернациональ Гмбх Лечение генотипированных пациентов с диабетом ингибиторами дпп-4, такими как линаглиптин
CN102869667A (zh) * 2010-02-19 2013-01-09 贝林格尔.英格海姆国际有限公司 三环吡啶衍生物、包含此化合物的药物、其用途及其制备方法
BR112012025592A2 (pt) 2010-04-06 2019-09-24 Arena Pharm Inc moduladores do receptor de gpr119 e o tratamento de distúrbios relacionados com os mesmos
BR112012028136A2 (pt) 2010-05-05 2016-08-09 Boehringer Ingelheim Int terapia de combinaçao
KR20130093012A (ko) 2010-06-24 2013-08-21 베링거 인겔하임 인터내셔날 게엠베하 당뇨병 요법
PE20131371A1 (es) 2010-09-22 2013-11-25 Arena Pharm Inc Moduladores del receptor gpr119 y el tratamiento de trastornos relacionados con este
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
CN102617566B (zh) * 2011-01-30 2015-03-04 山东轩竹医药科技有限公司 吡啶并咪唑烷衍生物
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CN104478880B (zh) * 2014-12-26 2016-03-02 浙江永太科技股份有限公司 作为dpp-iv抑制剂的双胍衍生物
CN104478879B (zh) * 2014-12-26 2016-03-02 浙江永太科技股份有限公司 一种作为二肽基肽酶-4抑制剂的化合物
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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599338A (en) * 1984-01-17 1986-07-08 Adir, S.A.R.L. Antimigraine 8-[3-(4-aminocarbonyl piperazino and piperidino) propyl[xanthines

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599338A (en) * 1984-01-17 1986-07-08 Adir, S.A.R.L. Antimigraine 8-[3-(4-aminocarbonyl piperazino and piperidino) propyl[xanthines

Also Published As

Publication number Publication date
CN101503409A (zh) 2009-08-12
CN101503409B (zh) 2014-01-22
ZA200500087B (en) 2006-07-26
DE10238243A1 (de) 2004-03-04
CN101503408A (zh) 2009-08-12
UA97468C2 (ru) 2012-02-27

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