CN101502281A - Method for preparing nitric oxide releasing tablet - Google Patents
Method for preparing nitric oxide releasing tablet Download PDFInfo
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- CN101502281A CN101502281A CNA2009100145118A CN200910014511A CN101502281A CN 101502281 A CN101502281 A CN 101502281A CN A2009100145118 A CNA2009100145118 A CN A2009100145118A CN 200910014511 A CN200910014511 A CN 200910014511A CN 101502281 A CN101502281 A CN 101502281A
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- nitric oxide
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- oxide releasing
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Abstract
The present invention relates to a method for preparing a nitric oxide releasing tablet. The nitric oxide releasing tablet is prepared through uniformly mixing the synthesized adduct comprising polyamine and nitric oxide, solid acid and furnace-dried water absorber, comminuting and tabletting. The tablet can automatically release nitric oxide in damp environment and has the advantages of simple processing technique and suitability for industrial mass production. The tablet of the invention is suitable for storing and executing fresh-keeping to the fruits of yangtao, Feicheng peach, apple, strawberry, plum, etc., and the gardening products of vegetable, cut flower, etc., and the agricultural product.
Description
(1) technical field
The present invention relates to the preparation method of nitric oxide releasing tablet, this tablet can be applied to the preservation and freshness of gardening products such as fruits such as Kiwi berry, Feicheng-peach, apple, strawberry, plum and vegetables, Fresh Cutting flower and agricultural product.
(2) background technology
The generation and the effect of Leshem in 1996 and the endogenous nitric oxides of Haramaty reported first industrial crops (NO), and propose with the regulatory factor of NO as fruit maturation, after this further discover, the endogenous NO amount that fruit produces reduces gradually, ethylene levels raises gradually, NO is relevant with the biosynthesis of gardening product ethene, and NO can suppress fruit maturation and aging.Calendar year 2001 Leshem etc. has proposed the concrete binding mode of NO in the ethene regulation and control: two rate-limiting enzyme acc oxidases during the NO ethene suppressing is synthetic and ACC synthase activity, thus reduce the rate of release of ethene and related substances thereof.A large amount of research has proved that the NO with suitable physiological concentration handles gardening product, can not damage fruit, effectively ethene suppressing generates and effect on the contrary, prolong the shelf-life of adopting the back fruit, this mainly shows the physiological effect of following several respects: (1) NO can reduce the moisture loss of gardening product, and this may suppress respiration with NO, reduce moisture transpiration, to reduce the nutriment loss relevant.The NO of debita spissitudo handles the appearance that can delay gardening product respiratory climacterics such as Kiwi berry, tomato, strawberry, reduces the fruits respiratory peak value.(2) NO can make gardening product keep better hardness, the softening of inhibition fruits such as it may change by metabolism and the enzymatic activity that influence the fruit cell wall, biomembrane fat acid compositions, the peroxidating of film fat.(3) NO handles and can delay the decomposition of Kiwi berry pericarp chlorophyll significantly, suppresses the pericarp annesl, makes the kiwifruit fruit long period keep green.(4) NO handles white ripe phase winter-jujube fruit, can significantly reduce the content of acetaldehyde and ethanol in the duration of storage fruit, thereby slows down the softening speed of brown stain.(5) handle the peach fruit with NO and occur slightly damaging to plants caused by sudden drop in temperature behind storage 40d, discover that NO can improve cryopreservation peach fruit exo2PG and endo2PG activity, and reduce PME and inscribe 1, the 4-dextranase activity loses thereby alleviate low temperature peach fruit wadding.
The NO processing mode adopts modes such as gas is stifling, solution leaching more.Because NO is a kind of hydroxyl radical gas molecule, easily by the oxygen reaction in air or the water, so NO preserves, transports and uses and must carry out under oxygen free condition.Preservation and use are very inconvenient and can not carry out industrial treatment.Like this, remarkable although NO handles the fresh preservation effect, also be difficult to use in fresh-keeping industry.Based on this, the present invention proposes a kind of preparation method of nitric oxide releasing tablet, this tablet can at room temperature be preserved the several months, preserves more than 1 year at 0 ℃.Its application process is that tablet and fruit are sealed in the container, and tablet can absorb the moisture of respiration of fruits effect generation and slowly discharge NO, handles bringing great convenience to NO, and is easy to industrialization.
(3) summary of the invention
The objective of the invention is to handle the deficiency that fruits and vegetables exist in order to overcome existing NO, a kind of new nitric oxide releasing tablet is provided, preparation technology is simple, but industrialized mass.
Technical scheme of the present invention is: according to document (Hrabie J A, Klose J R, Wink D A, Keefer L K.J.Org.Chem., 1993,58:1472～1476.) synthetic nitric oxide donors, press proper proportion mixing porphyrize with the water absorbing agent after solid acid, the oven dry, make tablet.
Nitric oxide donors described in the technique scheme is polyamines and nitric oxide production adduct.
Solid acid described in the technique scheme can be citric acid, tartaric acid, malic acid etc.
Water absorbing agent described in the technique scheme can be macromolecule water absorbent material, wheat or the cornstarch etc. of chemical synthesis.
The ratio of above-mentioned nitric oxide donors, solid acid, its each composition of water absorbing agent is by weight as follows:
Nitric oxide donors: 0.4%～6%
Solid acid: 30%～50%
Water absorbing agent: 40%～90%
Compared with prior art, advantage of the present invention is:
1. tablet producing technology is simple, and low, the high efficiency of cost has vast market prospect.
2. tablet and fruit are sealed in the container, tablet can absorb the spontaneous slow release NO of moisture, this method is handled fruit, easy and simple to handle, safe, to the fruit and vegetable food non-residual toxicity, can be widely used in the preservation and freshness of fruit such as Kiwi berry, Feicheng-peach, apple, strawberry, plum and gardening products such as vegetables and flowers, have very high value.
(4) description of drawings
Fig. 1 is the technology of the present invention process chart.
1 is synthetic nitric oxide donors among the figure, the 2nd, and the oven dry water absorbing agent, the 3rd, weigh, the 4th, mixing grinds, and the 5th, compressing tablet, the 6th, finished product.
Fig. 2 is the pictorial diagram of nitric oxide releasing tablet among the present invention.
Fig. 3 is NO concentration changes with time figure when divinyl triamine and nitric oxide adduct release tablet discharge NO and handle the apple fruit among the present invention.
Fig. 4 is spermine and nitric oxide adduct release tablet release NO and the real-time NO concentration changes with time of processing kiwi fruit figure among the present invention.
(5) specific embodiment
Below will the present invention is further illustrated by concrete example.
Embodiment one:
(1) divinyl triamine and nitric oxide adduct is synthetic
5.00g divinyl triamine is dissolved in the 150mL anhydrous acetonitrile, after the logical nitrogen 15min deoxygenation, feeds NO gas reaction 24h.The logical nitrogen in back that reacts completely is removed residue NO gas, the reactant mixture suction filtration, and vacuum drying gets 7.14g divinyl triamine and nitric oxide adduct.
(2) preparation of divinyl triamine and nitric oxide adduct release tablet
The oven dry wheaten starch takes by weighing 100mg divinyl triamine and nitric oxide adduct, 500mg citric acid respectively, the 1000mg wheaten starch is put in porphyrize mixing in the mortar, is pressed into 10.
Referring to accompanying drawing 3, with the ISO-NOPF200 electrode in conjunction with 1 divinyl triamine in Apollo 1000 free radical analyzers (U.S. WPI company) the monitorings 1L container and nitric oxide adduct NO that release tablet discharges over time, the result shows reach the highest 125 μ LL when 150min
-1, after this reduce gradually.After putting into the 250g apple, NO concentration reduces in the container, reaches the highest 102 μ LL when 180min
-1Illustrate that apple can fast Absorption divinyl triamine and the NO that produces of nitric oxide adduct release tablet, thereby cause that NO concentration reduces in the container.
Embodiment two:
(1) spermine and nitric oxide adduct is synthetic
The 5.00g spermine is dissolved in the 150mL anhydrous acetonitrile, after the logical nitrogen 15min deoxygenation, feeds NO gas reaction 20h.The logical nitrogen in back that reacts completely is removed residue NO gas, the reactant mixture suction filtration, and vacuum drying gets 6.39g spermine and nitric oxide adduct.
(2) preparation of spermine and nitric oxide adduct release tablet
The oven dry wheaten starch takes by weighing 100mg spermine and nitric oxide adduct, 420mg citric acid respectively, the 1000mg wheaten starch is put in porphyrize mixing in the mortar, is pressed into 10.
Referring to accompanying drawing 4,1 spermine and nitric oxide adduct release tablet are put into the 4L container, in conjunction with putting in Apollo 1000 free radical analyzers (U.S. WPI company) the monitorings container and the concentration of NO when not putting Kiwi berry, the result shows when not putting Kiwi berry that when 270min NO concentration reaches the highest 87 μ LL in the container with the ISO-NOPF200 electrode
-1, and NO concentration is low when not putting Kiwi berry all the time when putting Kiwi berry, reaches the highest 61 μ LL when 300min
-1, illustrate that Kiwi berry can the fast Absorption spermine and the NO that produces of nitric oxide adduct release tablet, thereby cause that NO concentration reduces in the container.
Preparation technology of the present invention is simple, and low, the high efficiency of cost has vast market prospect.Handle fruit with this method, easy and simple to handle, safe, to the fruit and vegetable food non-residual toxicity, can be widely used in the preservation and freshness of fruit such as Kiwi berry, Feicheng-peach, apple, strawberry, plum and gardening products such as vegetables and flowers, have very high value.
Claims (5)
1. the preparation method of a nitric oxide releasing tablet, it is characterized in that: this tablet is made up of nitric oxide donors, solid acid, water absorbing agent, and the ratio of its each composition is by weight as follows:
Nitric oxide donors: 0.4%～6%
Solid acid: 30%～50%
Water absorbing agent: 40%～90%
2. the preparation method of nitric oxide releasing tablet according to claim 1 is characterized in that described nitric oxide donors can be the polyamines and the nitric oxide adduct of preparation.
3. the preparation method of nitric oxide releasing tablet according to claim 1 is characterized in that described solid acid can be citric acid, tartaric acid, malic acid etc.
4. the preparation method of nitric oxide releasing tablet according to claim 1 is characterized in that described water absorbing agent can be macromolecule water absorbent material, wheat or the cornstarch etc. of chemical synthesis.
5. the preparation method of nitric oxide releasing tablet according to claim 1, it is characterized in that with the water absorbing agent after above-mentioned polyamines and nitric oxide adduct and solid acid, the oven dry in proportion behind the mixing compressing tablet make.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN2009100145118A CN101502281B (en) | 2009-02-26 | 2009-02-26 | Method for preparing nitric oxide releasing tablet |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100145118A CN101502281B (en) | 2009-02-26 | 2009-02-26 | Method for preparing nitric oxide releasing tablet |
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| Publication Number | Publication Date |
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| CN101502281A true CN101502281A (en) | 2009-08-12 |
| CN101502281B CN101502281B (en) | 2012-05-30 |
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| CN2009100145118A Expired - Fee Related CN101502281B (en) | 2009-02-26 | 2009-02-26 | Method for preparing nitric oxide releasing tablet |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102845513A (en) * | 2012-09-17 | 2013-01-02 | 浙江农林大学 | Method for accelerating wound healing of sweet potatoes |
| CN104397148A (en) * | 2014-11-24 | 2015-03-11 | 柳州市天姿园艺有限公司 | Special preservative for prunes |
| CN107183169A (en) * | 2017-07-11 | 2017-09-22 | 山东农业大学 | A kind of fresh preserving agent for fruit and vegetable and preparation method thereof |
| CN115926352A (en) * | 2022-09-30 | 2023-04-07 | 陕西科技大学 | Fresh-keeping preparation for prefabricated vegetables, preparation method and application |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101195029A (en) * | 2006-12-06 | 2008-06-11 | 姜广良 | Application method of nitric oxide donator in enteron mucosal disease |
-
2009
- 2009-02-26 CN CN2009100145118A patent/CN101502281B/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102845513A (en) * | 2012-09-17 | 2013-01-02 | 浙江农林大学 | Method for accelerating wound healing of sweet potatoes |
| CN104397148A (en) * | 2014-11-24 | 2015-03-11 | 柳州市天姿园艺有限公司 | Special preservative for prunes |
| CN107183169A (en) * | 2017-07-11 | 2017-09-22 | 山东农业大学 | A kind of fresh preserving agent for fruit and vegetable and preparation method thereof |
| CN115926352A (en) * | 2022-09-30 | 2023-04-07 | 陕西科技大学 | Fresh-keeping preparation for prefabricated vegetables, preparation method and application |
| CN115926352B (en) * | 2022-09-30 | 2023-11-17 | 陕西科技大学 | Prefabricated vegetable fresh-keeping preparation, preparation method and application |
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| Publication number | Publication date |
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| CN101502281B (en) | 2012-05-30 |
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