CN101501694B - 用于对蛋白质聚集进行预测以及设计聚集抑制剂的方法 - Google Patents

用于对蛋白质聚集进行预测以及设计聚集抑制剂的方法 Download PDF

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CN101501694B
CN101501694B CN2007800290322A CN200780029032A CN101501694B CN 101501694 B CN101501694 B CN 101501694B CN 2007800290322 A CN2007800290322 A CN 2007800290322A CN 200780029032 A CN200780029032 A CN 200780029032A CN 101501694 B CN101501694 B CN 101501694B
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amino acid
peptide
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sequence
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CN101501694A (zh
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卡伊·J·科尔霍夫
赫苏斯·苏尔多
米凯莱·文德鲁斯科洛
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Lonza Biologics PLC
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    • G16B15/00—ICT specially adapted for analysing two-dimensional [2D] or three-dimensional [3D] molecular structures, e.g. structural or functional relations or structure alignment
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CN2007800290322A 2006-08-04 2007-07-24 用于对蛋白质聚集进行预测以及设计聚集抑制剂的方法 Expired - Fee Related CN101501694B (zh)

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US82155306P 2006-08-04 2006-08-04
US60/821,553 2006-08-04
PCT/GB2007/002789 WO2008015384A1 (en) 2006-08-04 2007-07-24 Method for predicting protein aggregation and designing aggregation inhibitors

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CN101501694A CN101501694A (zh) 2009-08-05
CN101501694B true CN101501694B (zh) 2011-11-30

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US (1) US8290713B2 (cg-RX-API-DMAC7.html)
EP (1) EP2047393A1 (cg-RX-API-DMAC7.html)
JP (1) JP2009545756A (cg-RX-API-DMAC7.html)
KR (1) KR20090047470A (cg-RX-API-DMAC7.html)
CN (1) CN101501694B (cg-RX-API-DMAC7.html)
AU (1) AU2007280282B2 (cg-RX-API-DMAC7.html)
CA (1) CA2657847A1 (cg-RX-API-DMAC7.html)
EA (1) EA016884B1 (cg-RX-API-DMAC7.html)
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CN108780098A (zh) * 2016-01-06 2018-11-09 剑桥企业有限公司 基于化学动力学识别新型蛋白质聚集抑制剂的方法

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RU2442793C2 (ru) 2005-11-30 2012-02-20 Эбботт Лэборетриз АНТИТЕЛА ПРОТИВ ГЛОБУЛОМЕРА Аβ, ИХ АНТИГЕНСВЯЗЫВАЮЩИЕ ЧАСТИ, СООТВЕТСТВУЮЩИЕ ГИБРИДОМЫ, НУКЛЕИНОВЫЕ КИСЛОТЫ, ВЕКТОРЫ, КЛЕТКИ-ХОЗЯЕВА, СПОСОБЫ ПОЛУЧЕНИЯ УКАЗАННЫХ АНТИТЕЛ, КОМПОЗИЦИИ, СОДЕРЖАЩИЕ УКАЗАННЫЕ АНТИТЕЛА, ПРИМЕНЕНИЯ УКАЗАННЫХ АНТИТЕЛ И СПОСОБЫ ИСПОЛЬЗОВАНИЯ УКАЗАННЫХ АНТИТЕЛ
PL1976877T5 (pl) 2005-11-30 2017-09-29 Abbvie Inc Przeciwciała monoklonalne przeciwko białku amyloidu beta oraz ich zastosowania
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
US8895004B2 (en) 2007-02-27 2014-11-25 AbbVie Deutschland GmbH & Co. KG Method for the treatment of amyloidoses
GB2455102A (en) * 2007-11-28 2009-06-03 Cambridge Entpr Ltd Protein Aggregation Prediction Systems
WO2009128948A1 (en) 2008-04-17 2009-10-22 Peptimmune, Inc. Design and synthesis of directed sequence polymer compositions and antibodies thereof for the treatment of protein conformational disorders
CN110187119B (zh) * 2008-10-31 2022-07-29 耶鲁大学 子痫前期检测和治疗的方法和组合物
JP2013508308A (ja) * 2009-10-23 2013-03-07 ガーバン インスティテュート オブ メディカル リサーチ 修飾可変ドメイン分子、ならびにその産生および使用方法
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CN104502219B (zh) * 2014-12-18 2017-09-29 江苏大学 一种淀粉样多肽聚集抑制剂及其抑制效果评估和验证方法
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CN106501550A (zh) * 2016-12-09 2017-03-15 江苏大学 基于原子力显微镜氨基酸影响鱼蛋白聚集行为的评价方法
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108780098A (zh) * 2016-01-06 2018-11-09 剑桥企业有限公司 基于化学动力学识别新型蛋白质聚集抑制剂的方法
CN108780098B (zh) * 2016-01-06 2021-12-17 剑桥企业有限公司 基于化学动力学识别新型蛋白质聚集抑制剂的方法

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AU2007280282B2 (en) 2012-02-02
EA200970180A1 (ru) 2009-08-28
WO2008015384A1 (en) 2008-02-07
US8290713B2 (en) 2012-10-16
IL196551A (en) 2013-01-31
AU2007280282A1 (en) 2008-02-07
HK1131239A1 (en) 2010-01-15
EP2047393A1 (en) 2009-04-15
EA016884B1 (ru) 2012-08-30
WO2008015384A8 (en) 2008-05-15
KR20090047470A (ko) 2009-05-12
CA2657847A1 (en) 2008-02-07
IL196551A0 (en) 2009-11-18
US20100160602A1 (en) 2010-06-24
CN101501694A (zh) 2009-08-05
JP2009545756A (ja) 2009-12-24
SG173405A1 (en) 2011-08-29

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