CN101495167A - Antimicrobial vascular access device - Google Patents

Abstract

A medical device includes a body and an interior surface of the body that communicates with a fluid capable of delivering a pathogen to the interior surface. The medical device may also have an energy source coupled with the vascular access device that provides energy to the interior surface of the body to repress pathogenic activity. A method of repressing pathogenic activity in a vascular access device includes providing a body having an interior surface and energizing the vascular access device to repress pathogenic activity on the interior surface.

Description

Antimicrobial vascular access device

Technical field

The present invention relates to utilize the fluid transport therapy of antimicrobial vascular access device.Fluid transport therapy is one of modal health care procedures.Be in hospital, home care receive fluid, medicament and blood products with other patient by the vascular access device that inserts vascular system.Fluid transport therapy can be used to handle to infect, anesthesia or pain relieving are provided, nutritional support is provided, treat carcinous growth, keep blood pressure and the rhythm of the heart or a lot of other clinical significant purposes.

Background technology

Fluid transport therapy becomes easy because of vascular access device.Vascular access device can insert the vascular system at patient's periphery and center.This vascular access device is short-term (a couple of days), mid-term (several weeks) or long-term (several months is to the several years) stop therein.Vascular access device can be used to successive infusion treatment or be used for intermittent treatment.

Common vascular access device is a plastic catheter of inserting patient's vascular.Catheter length can change between many centimetres (inserting for the center) several centimetres (inserting for periphery).Conduit can insert through skin, perhaps implants the patient skin below by surgical operation.Conduit or any other access device that is attached thereto can have single intra-cavity or be used for injecting simultaneously a plurality of inner chambers of multiple fluid.

The near-end of vascular access device generally comprises Rule (Luer) joint, can connect other armarium on it.For example, fluid delivery apparatus can be connected with vascular access device by an end, and the other end is connected with venous transfusion (IV) bag.Fluid delivery apparatus is the fluid conduit systems that is used for injecting continuously fluid and medicament.Usually, the IV access device is a vascular access device, and it can connect another vascular access device, seals or seals this vascular access device and allow the intermittence of fluid and medicament to inject and input.The IV access device can comprise housing and be used for the barrier film of closed system.This barrier film can be opened with plush copper Rule (Luer) of blunt intubate or armarium.

Can cause significant sickness rate and even mortality rate with the fluid transport therapy complications associated with arterial system.A kind of significant complication is the relevant hematogenous infection (CRBSI) of conduit.In the hospital of the U.S., annual estimation will take place 250,000-400, the hematogenous infection (BSI) that 000 routine central venous catheter (CVC) is relevant.The mortality rate that causes thus is estimated as 12%-25%/each infection, and each incident needs 25,000-56,000 dollar healthcare network expense.

Regularly rinser, non-sterile insertion technology or after inserting conduit the arbitrary end of pathogenic bacteria by fluid flow path enter this path and all can cause the vascular access device infection, it causes CRBSI.Studies show that: the danger of CRBSI increases along with the increase of conduit dwell period.When vascular access device was subjected to polluting, pathogenic bacteria sticked on the vascular access device, breeds and forms biomembrane.This biomembrane can be resisted most biocide, and provides supplementary source for the pathogenic bacteria that enters patient's blood flow and inducing B SI.

Therefore need be used to suppress, limit or otherwise eliminate vascular access device and pollute system, apparatus and method with the dangerous and generation that reduces CRBSIs.

Summary of the invention

The present invention is in response to that problem in this area that does not solve fully as yet by current available vascular turnover system, apparatus and method and demand develop.Therefore, danger and the generation of pollution to reduce CRBSI of vascular access device forbidden, limits or otherwise eliminated to the system that is developed, apparatus and method.

Armarium can be the vascular access device that comprises main body and body inner surface.The inner surface participant is delivered to this surperficial fluid communication with pathogenic bacteria.Provide energy to suppress pathogenic activity with the coupled energy source of this vascular access device to body inner surface.This armarium has internal structure, main body outer surface and the external magnet that contacts the main body outer surface of contact body inner surface.In this embodiment, energy source is the action of a magnetic field power between external magnet and the internal structure of being in that can cause internal structure motion.

Body inner surface can be formed by decomposable biocompatible material.This inner surface can be formed by conductive material, and wherein energy source is the battery that transmits electric current to conductive material.This inner surface can also comprise heat conductor, and wherein energy source is to the heat conductor transfer of heat.Energy source can comprise make inner surface fast, repeatedly the motion agitator, wave producer or antibacterial applicator.Energy source can also be enough to suppress the electric current of pathogenic activity and comprise the anti-bacterial fluid that is applied on the body inner surface to fluid transmission size and persistent period with ultraviolet light emission to the inner surface of main body.

The method that suppresses the pathogenic activity in the vascular access device can comprise vascular access device that the main body with band inner surface is provided and provide energy to suppress the pathogenic activity on the inner surface to vascular access device.

Provide energy can comprise exciting magnet with upset reside in pathogenic bacteria on the inner surface, make inner surface decompose, to inner surface provide electric current, to heat conductor heat, make the inner surface vibration, produce and to inner surface transmit a series of ripples, to inner surface carry out disinfection, inside surface emitting ultraviolet light and/or wash vascular access device with anti-bacterial fluid.

Armarium can also comprise instrument that inserts patient's vascular system and the instrument that is used to suppress pathogenic bacteria.Pathogenic bacteria can reside in the instrument that is used for inserting patient's vascular system.The instrument that is used to suppress can comprise energy source.

These and other feature and advantage of the present invention can be incorporated among some embodiment of the present invention, and will become more obvious from following description and the claim of being submitted to, perhaps can be by being understood according to the such the present invention of enforcement who states below.The present invention does not require all favorable characteristics described here and all advantages is all incorporated among each embodiment of the present invention.

Description of drawings

Obtain the mode of above-mentioned and further feature of the present invention and advantage for easy to understand, will be by the present invention who is briefly described in the above being described more specifically with reference to specific embodiment of the present invention, wherein said specific embodiment is shown in the accompanying drawing of being submitted to.These accompanying drawings have only been described exemplary embodiments of the present invention, therefore should not be understood as that to limit the scope of the invention.

Fig. 1 is the perspective view that connects the Extravascular system of patient's vascular system;

Fig. 2 is the side view with the vascular access device that revolves ring;

Fig. 3 is the cross-sectional view that the vascular access device of Fig. 2 A-A along the line obtains;

Fig. 4 is the cross-sectional view with vascular access device of plastic hoop;

Fig. 5 is the partial cross section view that the vascular access device of Fig. 4 A-A along the line obtains;

Fig. 6 is the cross-sectional view with the vascular access device that decomposes the surface;

Fig. 7 is the partial cross section view with vascular access device of electrically conductive inner surface;

Fig. 8 is the membranous cross-sectional view with vascular access device of heat conductor;

Fig. 9 is the membranous cross-sectional view with vascular access device of agitator;

Figure 10 is the cross-sectional view with the coupled vascular access device of wave producer;

Figure 11 is the side view with the coupled vascular access device of supersonic generator;

Figure 12 is the cross-sectional view with the coupled vascular access device of lobate stopper that is added with medicine;

Figure 13 is the side view with vascular access device of the protection block that is added with medicine, and wherein the protection block is shown in an open position;

Figure 14 is the side view of the vascular access device of Figure 13, and wherein the protection block is in the close position;

Figure 15 is the transparent side view of vascular access device and the side view with block of ultraviolet LED bulb;

Figure 16 is the transparent side view of the alternative embodiment of the vascular access device of Figure 15 and block;

Figure 17 is the membranous partial cross section view with the coupled vascular access device of ultraviolet source;

Figure 18 is vascular access device and ultraviolet light isolator and the perspective view that exposes device;

Figure 19 is the transparent side view that has with the Extravascular system and the vascular access device of the coupled ultraviolet source of conduit;

Figure 20 is and the perspective side elevation view of the coupled vascular access device of ultraviolet source that wherein said ultraviolet source then is coupled with conduit;

Figure 21 is the cross-sectional view of blocking a shot with the coupled sterilization of the side view of vascular access device;

Figure 22 is the cross-sectional view of the battery of vascular access device, conduit and ground connection;

Figure 23 is the cross-sectional view with the coupled vascular access device in flushing pressure unit;

Figure 24 is the more detailed cross-sectional view of the vascular access device of Figure 23.

The specific embodiment

Currently preferred embodiments of the present invention will be by obtaining best understanding with reference to the accompanying drawings, and wherein similarly reference number is indicated consistent or functionally similar element.Will readily appreciate that: the part of the present invention that illustrates with describe, in general terms as herein accompanying drawing can be set up and be designed to various not isostructures.Therefore, do not wish desired scope of the present invention is caused restriction as the following more detailed explanation that accompanying drawing is described, and only be used to describe currently preferred embodiments of the present invention.

Referring now to Fig. 1,, vascular access device (equipment that also claims vascular external equipment, vein access device, access port and/or or a same-action attached with Extravascular system) 10 is used to pass skin 14 and enter patient 18 vascular 16 by conduit 12 guiding substances.Vascular access device 10 comprises main body 20 with inner chamber and the barrier film of being located in the inner chamber 22.Barrier film 22 has slit 24, and independently vascular external equipment 26 (such as syringe) can be introduced vascular access device 10 with material by slit 24.

Equipment 10 also comprises (below with reference to the accompanying drawings discuss) energy source, and it can suppress vascular access device 10 and/or connect pathogenic activity in the Extravascular system 28 of vascular access device 10.Energy source suppresses pathogenic activity to be reduced in the probability that bloodstream infection takes place in attached patient's body that any miscellaneous equipment on vascular access device 10 or the Extravascular system 28 arranged.

Pathogenic bacteria is access arrangement 10 or system 28 in several ways.For example, pathogenic bacteria just existed in equipment 10 or the system 28 before first the use.At the slit 24 that passes diaphragm 22 during, bring pathogenic bacteria into equipment 10 in outer surface that also can slave unit, the outer surface of autonomous device 26 and/or the surrounding with structure (such as the tip 30 of autonomous device 26) insertion equipment 10.From the fluid of autonomous device 26 injected systems, can introduce pathogenic bacteria.When use equipment 10, pathogenic bacteria can enter by the end 32 through conduit 12 during blood drawing or blood back and enter system 28 from vascular 16 at last.

As run through whole description described, energy source suppresses pathogenic activity by pathogenic bacteria being formed following active a kind of or combination, that is: remove, expulsion (dislodging), suppress growth, be attracted to a certain position, push away a certain position, surface or structure that pathogenic bacteria and/or its are adhered to come off, decompose, destroy, kill, heat, shear, interrupt, stop growth or propagation, irradiation, energising, flushing and/or other similar procedure or effect.Energy source comprises electricity, ultrasound wave, ultraviolet, magnetic, machinery, nanometer oscillator, agitator, white light, plasma, heat, electron beam and other similar energy source.Pathogenic bacteria comprises if enter patient and/or host's vascular system can cause disease, infects the host or in others there are the medium of harm or potential hazard in patient and/or host that it comprises protein, protozoon and/or other harmful microorganism and/or medium and products thereof of pathogenic bacteria, antibacterial, parasite, microorganism, fungus, virus, nursing pathogenic bacteria.At last, pathogenic activity comprise intrusion, propagation, resident from the teeth outwards, growth, propagation, tissue, development, evolve and/or other similarly enters and the activity of generation equipment 10, system 28 and/or vascular 16 in.

Referring now to Fig. 2,, vascular access device 10 comprise around the outer surface of equipment 10 revolve the ring 34.Revolve ring 34 and comprise that being embedded in it leads intravital Magnet 36.Magnet 36 provides the energy source of the action of a magnetic field power form, and described active force reaches internal structure 38 (Fig. 3) by the main body 20 of equipment 10.

Referring now to Fig. 3,, shows the cross section of the equipment 10 of Fig. 2 that A-A along the line obtains.As shown in Figure 3, the action of a magnetic field power externally transmitted between Magnet 36 and the internal structure 38 by the main body 20 by equipment 10 of external magnet 36 and being associated with internal structure 38.Internal structure 38 can be corresponding Magnet, ferrum or other metal, and/or other can be subjected to the magnetic conductive material of the action of a magnetic field power influence.The internal structure 38 externally following work of effect of Magnet 36 moves with the inner surface 40 along equipment 10 or advances.Therefore, when the outer surface 42 of operator's winding apparatus 10 moved or otherwise engages external magnet 36, internal structure 38 and external magnet 36 together moved to wipe, to stir or otherwise to upset inner surface 40 and resident thereon pathogenic bacteria 44 off.

Therefore, Fig. 2 and 3 embodiment provide a kind of vascular access device 10 with the action of a magnetic field power, and described the action of a magnetic field power can clear up, eliminate, upsets or the pathogenic bacteria 44 on the inner surface 40 of agitating equipment 10 otherwise.In use, operator are regularly revolved ring 34 on the outside of slewing 10.Revolve Magnet 36 on the ring and drag or influence magnetic strigil or internal structure 38 on the inboard, the biomembrane of any formation is cleared inner surface 40.In alternative embodiment, revolve ring 34 and can on an end of ring 34, comprise weight, so that any motion of equipment 10 all will cause weight at a direction pulling of gravity and/or momentum lower edge ring 34, make weight can make ring 34 with respect to equipment 10 rotations or rotation.When ring 34 rotated automatically because of the motion of equipment 10, internal structure 38 was with the inner surface of cleaning equipment 10.

Referring now to Fig. 4,, shows the cross section of vascular access device 10.Be positioned at the external magnet 52 that ring 46 on the outer surface 48 of equipment 10 comprises the knob 50 on the outer surface that is attached in ring 46 and is embedded in the plastics of ring 46.With closely similar with reference to figure 2 and 3 embodiment that describe, the external magnet 52 of the embodiment of Fig. 4 is as energy source, and it provides the action of a magnetic field power to influence inner magnet 54.Yet the inner magnet 54 of the embodiment of Fig. 4 comprises the antibiotic liner 56 that surrounds inner magnet 54.When the outer surface 48 of ring 46 winding apparatus 10 rotates, inner magnet 54 or other similar structures will be followed the path of external magnet 52, make the inner surface 58 of 56 pairs of equipment 10 of antibiotic liner clean.

Referring now to Fig. 5,, the partial cross sectional illustration of Fig. 4 has gone out the vascular access device 10 of Fig. 4.Fig. 5 shows plastic hoop 46, and it is contained in the external magnet 52 on the outer surface 48 of main body 20 of equipment 10.External magnet 52 applies the action of a magnetic field power by main body 20 to corresponding magnetisable material or inner magnet 54.Inner magnet 54 is attached with antibiotic wiper or antibiotic liner 56.Antibiotic liner 56 forms horse-shoe bend with corresponding with shape, size and the size of inner surface 58.Therefore, also can comprise along the antibiotic liner 56 of the antibiotic liner extension 60 of the arbitrary portion of inner surface 58 and be formed at the arbitrary portion that to clear up inner surface 58 when starting.

Therefore, the embodiment that describes with reference to Figure 4 and 5 provides the antibiotic liner of the body inner surface of the external magnet of outer surface of main body of contact vascular access device and respective inner Magnet and contact arrangement.When mobile external magnet, the magnetic energy source is moved inner magnet and corresponding antibiotic liner, thus the cleaning equipment inner surface.Compare with the embodiment that describe with reference to figure 2 and 3, the embodiment that describes with reference to Figure 4 and 5 provides a kind of chemical reaction, and it is used for killing pathogenic bacteria when pathogenic bacteria contacts antibiotic liner.And comprise internal structure or the Magnet of mechanically eliminating or otherwise destroy or eliminate the pathogenic bacteria that is touched with reference to figure 2 and 3 embodiment that describe.

The replacement of the embodiment that describes as reference Fig. 2-5, some embodiment can comprise other mechanical agitation in the inside of equipment 10.For example, can in equipment 10, leave pin or ball.Operator can rock equipment 10 so that pin or ball the are beated inner surface of collision equipment 10, thus the fluid there stirred.

With reference now to Fig. 6,, vascular access device 10 comprises decomposition surface 62 on the inner surface 64 of equipment 10.This decomposes surface 62 and is formed by decomposable biocompatible material, and described material can be dissolved in that infusion enters or pass through saline or other common venous transfusion of equipment 10.Surface 62 also can be designed to and particular fluid one same-action, and described particular fluid has the characteristic that can decompose surface 62 with the speed of needs.The purpose of decomposing surface 62 is to stop biomembranous formation by the fluidic inner surface 64 of contact injection is come off.Decomposing surperficial 62 makes the pathogenic bacteria biomembrane attracted to or be bonded in subsequently on the protein layer that forms on the surface 62 very difficult at the growth on the surface 62, protein in formation on the surface 62 or corresponding pathogenic bacteria.Because surface 62 is decomposed and come off from inner surface 64, described surface, biomembrane granule, protein and other pathogenic bacteria are advanced and enter patient's vascular system along the fluid path of equipment 10 with the surface 62 that comes off.Because pathogenic bacteria was not long enough to form deleterious bacterial cultures and/or biomembrane in the 62 last time of staying of surface, therefore compare with high-grade (advanced) injury that bacterial cultures caused, it is less to the injury that the patient causes that they invade patient's vascular system, and may the patient not damaged.Decomposing surface 62 can be applied on any vascular access device 10 that comprises intravenous catheter.

Referring now to Fig. 7,, the partial cross section view of vascular access device 10 has represented a kind of energy source that comprises battery 66, and the conductive material on the inner surface 72 of equipment 10 passed to electric current by lead 68 by described battery 66, such as metal coating 70.Battery 66 can be positioned on the arbitrary portion of equipment, and preferred on the outer surface 74 of equipment 10, near lead 68 and metal coating 70.Battery 66 provides electric current to metal level 70, so that the microorganism of the close inner surface 72 in the fluid path or pathogenic bacteria do not stick on surface 72 or the metal coating 70.Electric current needn't be by force to being enough to kill pathogens; Its needs do not stop it expulsion pathogenic bacteria or protein and do not form deleterious biomembrane subsequently on metal coatings 70.In alternative embodiment, there is not metal coating 70.On the contrary, the solution of contact inner surface 72 passed to electric current by lead 68.This solution is harmful to biomembranous environment in providing expulsion pathogenic bacteria or protein or otherwise making pathogenic bacteria or protein can not occur and form subsequently.

Referring now to Fig. 8,, the cross-sectional illustration of the barrier film 22 of vascular access device 10 goes out to have on the inner surface 78 of the equipment of being positioned at 10, near or heat conductor, heating element heater or other resistive film heater 76.Heat conductor 76 can be positioned at the inner surface 78 of barrier film 22 or equipment 10 other arbitrary portion, go up or near.Energy source (such as battery 80) provides energy to resistive film heater 76, makes heater 76 be heated to harmful or fatal level with regard to pathogenic bacteria.The main body of barrier film 22 can be formed by silicones or other material that can resist the excessive temperature up to 500 to 600.Therefore, heat conductor 76 can be heated to deleterious temperature with regard to pathogenic bacteria, simultaneously the material of the other parts of barrier film 22 or equipment 10 is not damaged or destroys.During use, by operator's manual triggers and/or by the external power source on the outer surface that is rotated in equipment 10, battery 80 can regularly and automatically transmit energy to heat conductor 76.When external power source was attached on the equipment 10,76 of heat conductors can be started working according to the automatic or manual program according to operator's requirement.

Referring now to Fig. 9,, shows the cross-sectional view of the barrier film 22 of vascular access device 10.Barrier film 22 comprises the agitator 88 on the outer surface 82 that is attached to barrier film 22, and agitator 88 is the form with the attached piece 84 of piezoelectric element 86.Agitator 88 form with outer surface 82 repeatedly and Fast Collision, make inner surface 90 fast vibrations of barrier film 22 and the opposite side of collision barrier film 22.When inner surface 90 fast vibrations collisions opposite side 92, the slit 24 of barrier film 22 in, form heat and friction, thereby suppress the interior pathogenic activity of slit 24 by killing the antibacterial that rests on the there.

Referring now to Figure 10,, vascular access device 10 can comprise hand-held wave producer 94, perhaps otherwise is coupled with hand-held wave producer 94.Wave producer 94 can place the over top of vascular access device, and operator can open generator 94 to send microwave or shock wave to the direction of equipment 10.The generation of microwave or shock wave is according to specific circulation, and it comprises pulse frequency, wavelength, amplitude, cycle and persistent period.Microwave can be used to stimulate antibacterial or other pathogenic cell, makes described cell overheated and dead.Shock wave can be used to shred antibacterial or other pathogenic cell or it is separated with near other hazardous medium.Therefore the embodiment that describes with reference to Figure 10 provides the energy source for the wave producer that can suppress pathogenic bacteria.

Referring now to Figure 11,, vascular access device 10 is kept by supersonic generator 96 on its outer surface.Operator can be with supersonic generator 96 as a kind of energy source, and it is used to any antibacterial and any biomembrane of smashing on the inner surface that is formed on equipment 10 in the equipment of killing 10.Supersonic generator 96 can also be fixedly connected on the equipment 10 to rock and to kill any pathogenic bacteria in the equipment 10.

Referring now to Figure 12,, the cross section of vascular access device shows the lobate stopper 98 that is added with medicine, and it is as the antibacterial applicator.This antibacterial applicator is the chemical energy source of the pathogenic bacteria on a kind of inner surface 100 that can suppress the equipment of staying 10.In the use of equipment 10, stopper 98 can be as required or demand be operated personnel and insert and extract.

Referring now to Figure 13,, the side view of vascular access device 10 shows the protection block 102 on the end face 104 of the equipment of being integrated in 10.Protection block 102 comprises the lobate stopper of describing with reference to Figure 12 that is added with medicine.Over cap 102 also pivots on hinge 106, and described hinge 106 is attached with the end face 104 of equipment 10.

Referring now to Figure 14,, the vascular access device 10 of Figure 13 is illustrated, and wherein protection block 102 is in the close position.When protection block 102 was in the close position, the lobate stopper that is added with medicine inserted the slit 24 of the barrier film 22 of equipment 10, so that be added with the inner surface that may have pathogenic bacteria on its of stopper contact arrangement 10 of medicine.The dosing surface or the antibacterial that are added with the liner of medicine or stopper will killing pathogenic bacteria.The stopper of describing referring to Figure 13 and 14 that is added with medicine can comprise headliner 108 (shown in Figure 13), it provides medicine or other antibacterial of saturated reserves, and described medicine or antibacterial can be by capillarities or otherwise advanced and finally arrive at the inner surface of equipment 10 along the length that is added with the stopper of medicine.

Referring now to Figure 15,, can clear up the built-in vascular access device 10 that pathogenic bacteria is arranged of its main body by energy source, wherein said energy source is to the arbitrary portion emission ultraviolet light of the inner surface 110 of main body 20.The energy source that sends ultraviolet light can be the block 112 with ultraviolet LED bulb, and wherein bulb is plush copper Rule (Luer) of autonomous device 26 (Fig. 1) or most advanced and sophisticated 30 shape.Block 112 comprises the ultraviolet LED bulb 114 that energy is provided by battery 116.Bulb 114 is opened when block 112 is attached on the equipment 10.Bulb 114 can be by operator's manual unlocking, perhaps 112 opens automatically with the interconnect function of equipment 10 because of blocking a shot.For example, when block 112 was screwed on the screw thread of equipment 10, two contact points that connect battery 116 and bulb 114 can align, and made circuit between bulb 114 and the battery 116 be switched on bulb 114 and were illuminated.

The ultraviolet LED bulb 114 of block 112 can be used to provide necessary strength and persistent period with the pathogenic bacteria in the suppression equipment 10.In alternative embodiment, the ultraviolet LED bulb needn't run through the slit 24 of barrier film 22 just can be according to the barrier film 22 of saturating equipment 10.In another embodiment, the ultraviolet LED bulb slit 24 that needn't run through shell 20 or barrier film 22 just can send the ultraviolet light by the shell 20 of equipment 10.

Referring now to Figure 16,, the embodiment that describes referring to Figure 15 can improve the energy source that suppresses pathogenic bacteria with ultraviolet light to provide with other scheme or structure.In alternative embodiment shown in Figure 16, the vascular access device that contains pathogenic bacteria can be sterilized with the rinse solution 120 of ultraviolet source 118 and injection device 10.Rinse solution 120 is designed to best ultraviolet light be reached through rinse solution 120 from light source 118 all inner surfacies 122 of equipment 10.As a supplement or replace, the embodiment that describes referring to Figure 16 can comprise intravenous catheter or other structure 124, and it provides from light source 118 along the catheter length transmission ultraviolet light reflexive or the fluorescence emission of ultraviolet light with all parts to inner surface 122.In this way, the various embodiment that describe referring to Figure 16 provide ultraviolet light are reached in the equipment 10 to suppress the means of pathogenic bacteria.

Referring now to Figure 17,, ultraviolet light energy source 126 is inserted into the slit 24 of the barrier film 22 of vascular access device 10.UV source 26 is molding LED covers of light guide or customization, and its shape is made into to be suitable for being installed in the slit 24 of barrier film 22.The shape of light source 126 makes light source directly to launch ultraviolet lights to the inner surface 128 of equipment 10.In case of necessity, the shape that can revise light source 126 is to allow directly ultraviolet light to be injected or any inner surface 128 of directive vascular access device 10.This modification will provide can the maximum ultraviolet source 126 that suppresses pathogenic activity.

Referring now to Figure 18,, vascular access device 10 can and expose device (exposer) 130 by hand-held ultraviolet light isolator to be surrounded fully or covers.Hand-held ultraviolet source 130 is included as around the pipeline 134 that stretches out of equipment 10 necessary otch 132 is installed.In the time of above placing equipment 10, hand-hold light source 130 will provide an isolated environment, and its zone that may contain pathogenic bacteria on vascular access device 10 or its inside provides high-intensity ultraviolet light.When starting, hand-hold light source 130 will provide to pathogenic bacteria is enough to suppress its active ultraviolet light.

Referring now to Figure 19,, vascular access device 10 can be attached with ultraviolet light energy source 136.Ultraviolet source 136 is attached in the fluid path downstream of Extravascular system 28, and wherein said system 28 is attached with equipment 10.For example, light source 136 can be attached on the replacement path (alternate pathway) 138 of conduit 140, wherein conduit 140 connection devices 10.Ultraviolet source 136 is injected the main body of conduit 140 through replacing path 138 with ultraviolet light then, and finally enters and the inner surface 142 of collision equipment 10.Ultraviolet light will be along the whole length suppression equipment 10 in the ultraviolet light path between light source 136 and the equipment 10 and/or the pathogenic bacteria of conduit 140 inside.In the process of vascular external system 28 application of substances, fluid or other medicines, light source 136 can regularly start and/or close.

Referring now to Figure 20,, the alternative embodiment of the embodiment that describes referring to Figure 19 is illustrated.In this embodiment, ultraviolet source 144 directly is attached on the vascular access device 10 in placed in-line mode.Therefore, the bottom of vascular access device 10 is connected to the top of light source 144, and the bottom of light source 144 is connected to conduit 146.The mode that the light source 144 of Figure 20 suppresses pathogenic bacteria is similar to the light source 136 of Figure 19.

Referring now to Figure 21,, the inner surface of the 148 pairs of vascular access devices 10 of blocking a shot by sterilizing carries out disinfection.Sterilization block 148 is with a plurality of characteristics combination embodiment together among the previous embodiment (for example embodiment that describes referring to Figure 12-17).Identical with present embodiment is, the feature of any embodiment that described in the literary composition can make up the energy source that can suppress pathogenic bacteria according to the principle of the invention to form with any feature of any other embodiment of describing in the literary composition.

As shown in figure 21, sterilization block 148 comprises battery 150, and it provides power to optical fiber rod 152.Optical fiber rod 152 provides ultraviolet light to the inner surface of equipment 10.The surface of optical fiber rod 152 is ground into and allows optical fiber rod 152 along the inner surface emission ultraviolet light of outward direction to equipment 10.Sterilization block 148 can also comprise medicine or antibacterial 154 on the surface within it.When sterilization block 148 engaged fully with vascular access device 10, optical fiber rod 152 was inserted into, and near or the inner surface of equipment oriented 10,148 the inner surface 154 of blocking a shot is placed with the end face 156 of equipment 10 and directly contacts.Then, 152 pairs of equipment inner surfacies of rod carry out disinfection, and the end face 156 of 154 pairs of equipment 10 of antibacterial carries out disinfection simultaneously.Sterilization block 148 is perhaps opened because of 148 junction apparatus 10 of blocking a shot automatically by operator's manual unlocking.

Sterilization block 148 can be launched ultraviolet light when engaging fully with equipment 10, and only is continuously the requisite a period of time of pathogenic bacteria in the suppression equipment 10.Light continue emission described in case of necessity between after, sterilization block 148 will stop at emission light in the equipment 10.Yet because block 148 still engages with equipment 10, antibacterial 154 will continue the slit 24 of the end face 156 of equipment 10 and barrier film 22 is protected and sterilized, to forbid any pathogenic bacteria intrusion equipment 10 when 148 junction apparatus 10 are blocked a shot in sterilization.When operator prepare after a while with equipment 10 when the patient injects fluid and/or blood detached the patient, operator will sterilize to block a shot and 148 move apart equipment 10.

Referring now to Figure 22,, vascular access device 10 comprises battery 158, and it is fixed on the main body 20 of vascular access device 10.Battery 158 comprises button 160, and operator can push or handle this button to start the operation of battery 158.In the operating process, battery 158 reaches inner chamber 166 by lead 162 with the outer surface 164 of electric current slave unit 10.So conduit 170 that electric current is flowed through and is contained in the fluid in the inner chamber 166 and enters adjacency along the length direction 168 of equipment 10.Electric current enters earth lead 174 from the inner chamber 172 of conduit 170 then.Earth lead 174 is then with the earth of electric current band from inner chamber 172 access arrangements 10 outsides.As an alternative, earth lead 174 returns to battery 158 to preserve electric charge for using in the future with electric current.

In use, the electric current of capacity passed the fluid of inner chamber 166 and 172 to suppress pathogenic bacteria from battery 158.Earth lead 174 is preferably placed between battery 158 and the patient, and is configured to prevent that the patient from receiving any electric current that enters patient's vascular system from battery 158.In the use of equipment 10, operator can be discharged into electric current in the equipment 10 from battery at optional preferred moment control button 160.

Referring now to Figure 23,, flushing pressure unit 176 is attached with vascular access device 10.Fluid is being sent into or is sending equipment 10 fast by inlet flow path 178 and output flow path 180 forward or on the opposite direction in flushing pressure unit 176.Flushing pressure unit 176 can inject any chloride sterilant fluid.The preferred operations that the inflow of equipment 10 and outflow direction can be vibrated and can be suppressed pathogenic activity to provide.When being rinsed pressure unit 176 and receiving, can be collected from the fluid of equipment 10, and assess after a while or otherwise analyze to determine whether equipment 10 has bred pathogenic bacteria.By analyzing, the characteristic of pathogenic bacteria can obtain confirming, and leaves appropriate processing scheme can for the patient of equipment 10 and/or affixation devices 10 based on the fluid assessment result.

Referring now to Figure 24,, the vascular access device of Figure 23 10 illustrates with cross-sectional view.Input fluid valve 178 comprises the flushing end 182 of bottom of the main body 20 of insertion equipment 10.The lower lumen 184 of flushing end 182 shutoff equipment 10.Flushing end 182 is the main body 20 of access arrangement 10 by running through sealing member 186, and wherein said sealing member 186 was opened by hinge through inserting flushing in most advanced and sophisticated 182 o'clock.When flushing end 182 was removed, sealing member 186 recovered its home position, and the main body 20 of formation and equipment 10 is continuously in case the fluid stopping body leaves equipment 10 by sealing member 186 and permission equipment 10 bears the wall of normal running.

Flushing end 182 comprises hand-hole 188 in its surface.Antimicrobial or other antimicrobial fluid pours the inner chamber 190 of equipment 10 by hand-hole 188.Hole 188 is positioned on the lip-deep different key positions of flushing end 182, sprays to the inner surface 192 of equipment 10 fast along all directions with the fluids that allow 188 injections from the hole.Because fluid sprays to all inner surfacies 192 fast, so surface 192 is cleared up and the pathogenic bacteria on it is inhibited.Then, fluid 194 is brought pathogenic bacteria and other deleterious material the end 30 of autonomous device 26 in the upward direction, perhaps by output flow path 180 shown in Figure 23.Fluidic direction 194 can be reverse, injects so that fluid passes through the regular inlet port or the slit 24 of barrier film 22, and leave by sealing member 186 after a while.Saline and/or any other fluid can push or push away inner chamber 190 by the hole of any amount in the main body 20 of end 30, flushing end 182 and/or equipment 10.

The present invention can realize with other particular form, and do not deviate from this generalized description and below the structure, method or other fundamental characteristics that require.It is illustrative, and not restrictive that described embodiment all only is considered as in all fields.Therefore, scope of the present invention is represented by the claim of being submitted to, rather than is represented by the description of front.Should be included in their scope in the implication of the equivalent of these claim and all conversion in the scope.

Claims (33)

1. armarium, it comprises:

Vascular access device, it comprises main body and body inner surface, wherein body inner surface and the fluid communication that pathogenic bacteria can be delivered to body inner surface; With

The energy source that links to each other with vascular access device, wherein energy source provides the energy that is enough to suppress pathogenic activity to body inner surface.

2. armarium as claimed in claim 1 also comprises:

The internal structure that contacts with body inner surface;

The main body outer surface; And

The external magnet of contact main body outer surface;

Wherein energy source is the action of a magnetic field power between Magnet and the internal structure externally, and

Wherein the motion of external magnet causes the motion of internal structure.

3. armarium as claimed in claim 1, wherein, body inner surface is formed by decomposable biocompatible material.

4. armarium as claimed in claim 1, wherein, body inner surface is formed by conductive material, and energy source is the battery that transmits electric current to conductive material.

5. armarium as claimed in claim 1, wherein, body inner surface comprises heat conductor, and energy source is to the heat conductor transfer of heat.

6. armarium as claimed in claim 1, wherein, energy source is to make fast and the repeatedly agitator of motion of body inner surface.

7. armarium as claimed in claim 1, wherein, energy source is a wave producer.

8. armarium as claimed in claim 1, wherein, energy source is the antibacterial applicator.

9. armarium as claimed in claim 1, wherein, energy source with ultraviolet light emission to body inner surface.

10. armarium as claimed in claim 1, wherein, energy source transmits its size and the persistent period is enough to suppress the electric current of pathogenic activity to fluid.

11. armarium as claimed in claim 1, wherein, energy source comprises the anti-bacterial fluid that is applied on the body inner surface.

12. a method that suppresses the pathogenic activity in the vascular access device, it comprises:

Vascular access device with main body is provided, and described main body has inner surface; And

Provide energy to suppress the pathogenic activity on the inner surface to vascular access device.

13. method as claimed in claim 12 wherein, provides energy to comprise that exciting magnet resides in pathogenic bacteria on the inner surface with upset.

14. method as claimed in claim 12 wherein, provides energy to comprise inner surface is decomposed.

15. method as claimed in claim 12 wherein, provides energy to comprise to inner surface electric current is provided.

16. method as claimed in claim 12, wherein, inner surface comprises heat conductor, wherein provides energy to comprise heat conductor is heated.

17. method as claimed in claim 12 wherein, provides energy to comprise and makes the inner surface vibration.

18. method as claimed in claim 12 wherein, provides energy to comprise to form and transmits a series of ripples to inner surface.

19. method as claimed in claim 12 wherein, provides energy to comprise inner surface is carried out disinfection.

20. method as claimed in claim 12 wherein, provides energy to comprise inside surface emitting ultraviolet light.

21. method as claimed in claim 12 wherein, provides energy to comprise with anti-bacterial fluid and washes vascular access device.

22. an armarium, it comprises:

Be used to enter the access to plant of patient's vascular system; And

Be used to suppress the restraining device of pathogenic bacteria, wherein pathogenic bacteria resides in and is used to enter in the device of patient's vascular system, and described restraining device comprises energy source.

23. armarium as claimed in claim 22, wherein said access to plant comprises:

Vascular access device, it comprises main body and body inner surface, wherein body inner surface and the fluid communication that pathogenic bacteria can be delivered to inner surface; And

Wherein energy source links to each other with vascular access device, and wherein energy source provides the energy that is enough to suppress pathogenic activity to body inner surface.

24. armarium as claimed in claim 23 also comprises:

The internal structure that contacts with body inner surface;

The main body outer surface; And

The external magnet of contact main body outer surface;

Wherein energy source is the action of a magnetic field power between Magnet and the internal structure externally, and

Wherein the motion of external magnet causes the motion of internal structure.

25. armarium as claimed in claim 23, wherein, body inner surface is formed by decomposable biocompatible material.

26. armarium as claimed in claim 23, wherein, body inner surface is formed by conductive material, and energy source is the battery that transmits electric current to conductive material.

27. armarium as claimed in claim 23, wherein, body inner surface comprises heat conductor, and energy source is to the heat conductor transfer of heat.

28. armarium as claimed in claim 23, wherein, energy source is to make fast and the repeatedly agitator of motion of inner surface.

29. armarium as claimed in claim 23, wherein, energy source is a wave producer.

30. armarium as claimed in claim 23, wherein, energy source is the antibacterial applicator.

31. armarium as claimed in claim 23, wherein, energy source with ultraviolet light emission to body inner surface.

32. armarium as claimed in claim 23, wherein, energy source transmits its size and the persistent period is enough to suppress the electric current of pathogenic activity to fluid.

33. armarium as claimed in claim 23, wherein, energy source comprises the anti-bacterial fluid that is applied on the body inner surface.

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