CN101491543A - Use of sea collagen peptide in preparing medicine or food capable of improving senility memory function - Google Patents
Use of sea collagen peptide in preparing medicine or food capable of improving senility memory function Download PDFInfo
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- CN101491543A CN101491543A CNA2008102283955A CN200810228395A CN101491543A CN 101491543 A CN101491543 A CN 101491543A CN A2008102283955 A CNA2008102283955 A CN A2008102283955A CN 200810228395 A CN200810228395 A CN 200810228395A CN 101491543 A CN101491543 A CN 101491543A
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Abstract
The invention relates to a marine collagen peptide product and application of the marine collagen peptide product in preparing a medicine or food for improving senile memory. Marine collagen peptide is a group of oligopeptide mixtures with low molecular weight produced by hydrolyzing fishskins of marine fishes (salmon, tilapia, and the like). 70 to 80 percent of molecular weight of oligopeptide is distributed between 200 and 1000Da. The marine collagen peptide product has the characteristics of easy absorption, quick absorption, low viscosity, good water solubility, and the like. An experiment proves that a senile mouse is provided with the marine collagen peptide so as to can remarkably improve the abilities of passive avoidance, active avoidance and spatial memory exploration of the senile mouse, and the marine collagen peptide product has the efficacy of improving the senile memory.
Description
Technical field
The present invention relates to a kind of marine bioactivity oligopeptide and new purposes thereof, is the purposes of marine collagen in improving senile memory medicine or food of extracting from marine fishes specifically.Belong to medicine, health care of food field.
Background technology
Aged tendency of population is one of human great social problem geared to the 21st century, will constitute the principal character of 21 century human social development.Along with aged tendency of population, " first killer " of cerebral retrogressive disease and cognitive function decline will the becoming mankind, particularly elderly population.It is reported that there is hypomnesis in 50% left and right sides main suit in the mid-aged population; Objective memory inspection can reach 32%～78% according to the unusual rate of different memory of testing method.At present the old dysmnesia patient in whole world number is about 2,000 ten thousand, and China patient number has reached 500-600 ten thousand, and among the old people of over-65s, nearly 5% suffers from dysmnesia, the age in the old people more than 85 years old this ratio near 50%.Old dysmnesia have now become the social problem of a serious harm human health, bring heavy spirit and financial burden for individual, family and society.Because memory is one of important content of big senior cognition functions of brain, up to the present, medical educational circles does not also find out effective method for treatment.
Hypomnesis also is one of early stage performance of old cognitive dysfunction disease (as dementia, parkinson disease etc.) except the influence life.Studies show that simple amnemonic old people has quite a few people to develop into dementia through in a few years.Alzheimer disease (Alzheimer ' s disease, AD) be a kind of chronic brain degeneration disease, mainly show as carrying out property memory, attention, orientation force and computing capability forfeiture, and involve language function, can cause at last losing self care ability fully, die from multiple complications.And the AD course of disease is very long sustainable 20 years, all is white elephant and misery to individual, family and society.In western countries, AD has become the 4th cause of the death after cardiovascular disease, malignant tumor and apoplexy.Along with the arriving of China's population aging society, AD also will become significant public health problem of China.Update shows China more than 60 years old in the population, and the AD prevalence is about about 5%, i.e. the existing AD patient about 6,000,000 of China.Therefore AD has become one of principal disease of current social serious threat China old people life.
Because old and feeble mechanism is not illustrated as yet fully, also lack effective treatment means for a series of old degenerative disease (as AD, parkinson disease etc.) that takes place in the aging course clinically at present.Therefore, in advance/the old amnemonic generation of early prevention, by a series of intervention means (as behavior, functional food etc.) elderly population is intervened, improve old man memory, improve the quality of living, and realize that successful aging all has great scientific meaning, also be one of key subjects of current biomedical research area research.
Biologically active peptide is meant the peptide matters with special physiological function.The Bayliss of London University's medical college in 1902 and Startling have found a kind ofly can cause the active material of pancreatic secretion from the gastrointestinal of animal, are called secretin, and this is the human biological activity peptide matters of finding for the first time.After this, be accompanied by the develop rapidly of biochemistry and Protocols in Molecular Biology, the research of peptide has obtained breakthrough, has become the new focus of present research.
Peptide and protein all are the chemical compounds that aminoacid is connected to form with amido link, and the aminoacid degree of polymerization of peptide is little than polymerization degree of protein.In addition; biologically active peptide has demonstrated antioxidation, antibiotic, antitumor, protection cardiovascular, immunomodulating, the anti-ageing biological action of waiting for a long time; and these functions are that single amino acids and parent protein are irreplaceable; these bioactive peptide be can use and medicine, vaccine and health product etc. can be used as; at present, R and D biologically active peptide based food has become a focus in international health product industry.Chinese patent application 01126649.X discloses the albumen-10.34 that a kind of polypeptide-human contains L-lactic acid dehydrogenase activity site, the polynucleotide of this polypeptide of encoding and produce the effect that the method for this peptide species and this polypeptide are used for the treatment of multiple diseases such as, renal failure not normal as the rhythm of the heart, metabolic cataract, peripheral neuropathy, infection through the DNA recombinant technique.Chinese patent application number 01126663.5 discloses the albumen-8.8 of a kind of polypeptide-human's phosphoric acid transferring enzyme system phosphorylation site, the encode polynucleotide of this polypeptide and produce the method for this peptide species and the method that this polypeptide is used for the treatment of multiple disease through the DNA recombinant technique,, renal failure not normal, metabolic cataract, peripheral neuropathy, infection etc. as the rhythm of the heart.
The ocean is the abundantest field of resource on the earth, since the ecological environment of marine organisms species than the terrestrial organism complexity many, it gives halobiontic some special chemical constitution is still undiscovered in the terrestrial life body, and this makes the ocean become the resource treasure-house of original new drug and functional health-care food.Since the seventies in 20th century, people have isolated the novel and special high activity of hundreds thousand of kinds of chemical constitutions, the bioactive substance of high-drug-effect from marine organisms, comprise peptide class, protein-based, polysaccharide, alkaloids, terpenoid, Macrocyclic polyester class etc.The peptide class is the hugest compounds of quantity in the marine bioactivity material, reaches tens thousand of kinds more than, and a lot of marine peptide classes have physiologically actives such as antioxidation, immunomodulating, resisting hypertension, antitumor, inhibition platelet aggregation.
The research that improves the senile memory effect for the marine bioactivity peptide at present also seldom, if reach and improve senile memory by the exploitation health food, the effect of prevention senile dementia generation, not only economy but also practicality will be brought very big prospect to the health-care industry of China.
Summary of the invention
The purpose of this invention is to provide a kind of low-molecular-weight marine collagen (MCPs) and improve the medicine of senile memory or the purposes in the food in preparation.
Marine collagen peptide product provided by the invention is the one group of low-molecular-weight oligo peptide that is produced through hydrolysis by the fish skin of marine fishes (Oncorhynchi, tilapia etc.).Peptide molecular weight is distributed as:＜130 Da contain 16.48%, 130～500 Da and contain 47.90%, 500～1000 Da and contain 22.13%, 1000～2000 Da and contain 10.63%, 2000～3000 Da and contain 2.18%, and＞3000Da contains 0.67%.Various amino acid contents are: aspartic acid 7.29%, glutamic acid 12.22%, serine 4.23%, histidine 1.61%, glycine 13.46%, threonine 2.53%, arginine 6.08%, alanine 6.59%, tyrosine 0.003%, cystine 1.21%, valine 2.94%, methionine 0.03%, phenylalanine 2.51%, isoleucine 2.57%, leucine 4.64%, lysine 5.66%, proline 6.71%, total amino acids 80.28%.In addition, also have easy absorption, absorb characteristics such as fast, low viscosity, good water solubility.
Wherein said medicine is powder, granule, capsule, tablet, pill.
Wherein said food is starch-based product, milk and milk products, bean product, baking goods.
Description of drawings:
Fig. 1 be in the step down test preparation of the present invention to preclinical influence.
Fig. 2 is the influence of preparation of the present invention in the space search test to the target quadrant persistent period.
Fig. 3 for preparation of the present invention in the space search test to passing through the influence of number of times.
Specific embodiments
The present invention is further illustrated below in conjunction with specific embodiments, and these examples should be understood that only to illustrate, but not limit the scope of the invention by any way.
Embodiment: marine collagen improves the experimental study of aged C57BL/6J mouse memory function
60 of the female C57BL/6J mices of cleaning level at test 15 monthly ages of employing, 15 of 3 monthly age C57BL/6J mices are provided by Department Of Medicine, Peking University's Experimental Animal Center, and SPF level Animal House is raised, 25 ℃ of feeding environment temperature, humidity 60%RH.Adaptability is raised after 3 days aged mouse is divided into aged matched group and basic, normal, high three marine collagen intervention group by body weight, feed MCP replaces the special processing feedstuff of 0,0.225%, 0.450% and 1.350% crude protein respectively, the feed of freely drinking water of the common mice growth of young C57BL/6J matched group feed feedstuff, all animals.Intervene the test of 5 months laggard capable behavioristicss, comprise step down test, the test of Morris water maze and shuttle box test,, detect antioxidase SOD activity and peroxidating product MDA level in the liver organization afterwards with sacrifice of animal.The result shows that marine collagen can improve the aged mouse memory function, improves its passive avoidance, active avoidance and spatial memory exploring ability (figure), and this improvement effect may partly realize by improving the body antioxidant activity
The result shows that preparation of the present invention has the function of improving old memory.
Preparation of the present invention is to the influence of aged Mus active avoidance response rate in table 1 shuttle box test
*: compared significant difference with aged control
#: compared significant difference with young control.
In the table 2Morris water maze test, preparation of the present invention is to the influence of aged Mus escape latency
*: compared significant difference with aged control, P＜0.05
#: compared significant difference with young control, P＜0.05.
Table 3 preparation of the present invention is to the influence of antioxidase SOD in the aged mouse liver organization and peroxidating product MDA
*: compared significant difference with aged control, P＜0.05
#: compared significant difference with young control, P＜0.05.
Claims (4)
1, a kind of marine collagen peptide product is characterized in that: the one group of low-molecular-weight oligo peptide that is produced through hydrolysis by the fish skin of marine fishes (Oncorhynchi, tilapia etc.).Peptide molecular weight is distributed as:＜130Da contains 16.48%, 130～500Da and contains 47.90%, 500～1000Da and contain 22.13%, 1000～2000Da and contain 10.63%, 2000～3000Da and contain 2.18%, and＞3000Da contains 0.67%.Various amino acid contents are: aspartic acid 7.29%, glutamic acid 12.22%, serine 4.23%, histidine 1.61%, glycine 13.46%, threonine 2.53%, arginine 6.08%, alanine 6.59%, tyrosine 0.003%, cystine 1.21%, valine 2.94%, methionine 0.03%, phenylalanine 2.51%, isoleucine 2.57%, leucine 4.64%, lysine 5.66%, proline 6.71%, total amino acids 80.28%.In addition, also have easy absorption, absorb characteristics such as fast, low viscosity, good water solubility.
2, the described marine collagen peptide product of claim 1 improves purposes in senile memory medicine or the food in preparation.
3, as claim 2, wherein said medicine is powder, granule, capsule, tablet, pill, oral liquid.
4, as claim 2, wherein said food is starch-based product, milk and milk products, bean product, baking goods.
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2008102283955A CN101491543A (en) | 2008-10-30 | 2008-10-30 | Use of sea collagen peptide in preparing medicine or food capable of improving senility memory function |
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| CNA2008102283955A CN101491543A (en) | 2008-10-30 | 2008-10-30 | Use of sea collagen peptide in preparing medicine or food capable of improving senility memory function |
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| CN101491543A true CN101491543A (en) | 2009-07-29 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102406174A (en) * | 2011-12-02 | 2012-04-11 | 安徽燕之坊食品有限公司 | Functional food composite and application |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102406174A (en) * | 2011-12-02 | 2012-04-11 | 安徽燕之坊食品有限公司 | Functional food composite and application |
| CN102406174B (en) * | 2011-12-02 | 2013-06-05 | 安徽燕之坊食品有限公司 | Functional food composite and application |
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Open date: 20090729 |