CN101479268B - 2-0’-甲基腺苷衍生物及其用作制备腺苷受体的激动剂或拮抗剂的应用 - Google Patents

2-0’-甲基腺苷衍生物及其用作制备腺苷受体的激动剂或拮抗剂的应用 Download PDF

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Publication number
CN101479268B
CN101479268B CN2007800239044A CN200780023904A CN101479268B CN 101479268 B CN101479268 B CN 101479268B CN 2007800239044 A CN2007800239044 A CN 2007800239044A CN 200780023904 A CN200780023904 A CN 200780023904A CN 101479268 B CN101479268 B CN 101479268B
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China
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pain
disease
methoxyl group
amino
adenosine
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Expired - Fee Related
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CN2007800239044A
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English (en)
Chinese (zh)
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CN101479268A (zh
Inventor
爱德华·丹尼尔·萨沃里
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Cambridge Biotechnology Ltd
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Cambridge Biotechnology Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN2007800239044A 2006-06-27 2007-06-26 2-0’-甲基腺苷衍生物及其用作制备腺苷受体的激动剂或拮抗剂的应用 Expired - Fee Related CN101479268B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
SE06013973 2006-06-27
SE0601397-3 2006-06-27
SE0601397 2006-06-27
US83740206P 2006-08-11 2006-08-11
US60/837,402 2006-08-11
PCT/EP2007/056377 WO2008000744A2 (en) 2006-06-27 2007-06-26 2-0'-methyladen0sine derivatives and their use as agonists or antagonists of an adenosine receptor

Publications (2)

Publication Number Publication Date
CN101479268A CN101479268A (zh) 2009-07-08
CN101479268B true CN101479268B (zh) 2012-08-08

Family

ID=38573394

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2007800239044A Expired - Fee Related CN101479268B (zh) 2006-06-27 2007-06-26 2-0’-甲基腺苷衍生物及其用作制备腺苷受体的激动剂或拮抗剂的应用

Country Status (10)

Country Link
US (1) US7820811B2 (https=)
EP (1) EP2081932A2 (https=)
JP (1) JP2009541437A (https=)
CN (1) CN101479268B (https=)
AU (1) AU2007263727A1 (https=)
BR (1) BRPI0713902A2 (https=)
CA (1) CA2654371A1 (https=)
NZ (1) NZ573307A (https=)
RU (1) RU2009102536A (https=)
WO (1) WO2008000744A2 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007263728A1 (en) * 2006-06-27 2008-01-03 Biovitrum Ab (Publ) Adenosine derivatives for the treatment of pain
WO2012048013A2 (en) * 2010-10-06 2012-04-12 Inhibitex, Inc. Phosphorodiamidate derivatives of guanosine nucleoside compounds for treatment of viral injections

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0269574A2 (en) * 1986-11-27 1988-06-01 Nippon Zoki Pharmaceutical Co. Ltd. Novel adenosine derivatives and pharmaceutical compositions containing them as an active ingredient
EP0490818A1 (en) * 1990-12-07 1992-06-17 Sandoz Ltd. 6-cyclohexyl-2'-0-methyl-adenosine hydrate and uses thereof
EP0601322A2 (en) * 1992-10-27 1994-06-15 Nippon Zoki Pharmaceutical Co., Ltd. Adenosindeaminase inhibitor

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5968914A (en) 1987-10-28 1999-10-19 Pro-Neuron, Inc. Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
ATE269870T1 (de) * 1989-10-24 2004-07-15 Isis Pharmaceuticals Inc 2'-modifizierte oligonukleotide
US5877180A (en) 1994-07-11 1999-03-02 University Of Virginia Patent Foundation Method for treating inflammatory diseases with A2a adenosine receptor agonists
ATE236922T1 (de) 1997-06-03 2003-04-15 Itochu Techno Chem Inc Natürliche antitumor- oder antivirale substanzen und ihre anwendung
US6576619B2 (en) 1999-05-24 2003-06-10 Cv Therapeutics, Inc. Orally active A1 adenosine receptor agonists
MXPA04012779A (es) 2002-06-28 2005-08-19 Idenix Cayman Ltd Profarmacos de 2'- y 3'-nucleosido para tratar infecciones por flaviviridae.
GB0228723D0 (en) 2002-12-09 2003-01-15 Cambridge Biotechnology Ltd Treatment of pain
GB0305150D0 (en) 2003-03-07 2003-04-09 Cambridge Biotechnology Ltd Use of therapeutic compounds
GB0305153D0 (en) 2003-03-07 2003-04-09 Cambridge Biotechnology Ltd Identification of therapeutic compounds
GB0305149D0 (en) 2003-03-07 2003-04-09 Cambridge Biotechnology Ltd Compounds for the treatment of pain
GB0328323D0 (en) 2003-12-05 2004-01-07 Cambridge Biotechnology Ltd Synthesis of 2-substituted adenosines
CA2557285A1 (en) * 2004-03-05 2005-09-15 Cambridge Biotechnology Limited Adenosine receptor agonists
AU2007263728A1 (en) * 2006-06-27 2008-01-03 Biovitrum Ab (Publ) Adenosine derivatives for the treatment of pain

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0269574A2 (en) * 1986-11-27 1988-06-01 Nippon Zoki Pharmaceutical Co. Ltd. Novel adenosine derivatives and pharmaceutical compositions containing them as an active ingredient
EP0490818A1 (en) * 1990-12-07 1992-06-17 Sandoz Ltd. 6-cyclohexyl-2'-0-methyl-adenosine hydrate and uses thereof
EP0601322A2 (en) * 1992-10-27 1994-06-15 Nippon Zoki Pharmaceutical Co., Ltd. Adenosindeaminase inhibitor

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Jayson M. Rieger,et al..Design, Synthesis, and Evaluation of Novel A2A Adenosine Receptor Agonists.《J. Med. Chem.》.2001,第44卷(第4期),531-539. *
JaysonM.Rieger et al..Design
Suhaib M. Siddiqi,et al..Search for New Purine- and Ribose-Modified Adenosine Analogs as Selective Agonists and Antagonists at Adenosine Receptors.《J. Med. Chem.》.1995,第38卷(第7期),1174–1188. *

Also Published As

Publication number Publication date
WO2008000744A2 (en) 2008-01-03
BRPI0713902A2 (pt) 2012-11-27
US20080009461A1 (en) 2008-01-10
NZ573307A (en) 2012-02-24
CA2654371A1 (en) 2008-01-03
WO2008000744A3 (en) 2008-02-28
RU2009102536A (ru) 2010-08-10
CN101479268A (zh) 2009-07-08
JP2009541437A (ja) 2009-11-26
US7820811B2 (en) 2010-10-26
EP2081932A2 (en) 2009-07-29
AU2007263727A1 (en) 2008-01-03

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