CN101478957A - Disposable infusion device with linear peristaltic pump - Google Patents
Disposable infusion device with linear peristaltic pump Download PDFInfo
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- CN101478957A CN101478957A CNA2007800201282A CN200780020128A CN101478957A CN 101478957 A CN101478957 A CN 101478957A CN A2007800201282 A CNA2007800201282 A CN A2007800201282A CN 200780020128 A CN200780020128 A CN 200780020128A CN 101478957 A CN101478957 A CN 101478957A
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- actuation button
- pump
- medicine
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Abstract
The invention discloses a portable infusion device, comprising a base part contacting a patient's skin and a reservoir for holding a liquid medicament to be infused into the patient. The reservoir has an outlet through which the medicament flows. The infusion device further comprises a flexible cannula communicating with the outlet of the reservoir and a pump conducting the medicament to flow downwards.
Description
Priority request
This application requires the U.S. Provisional Application No.60/809 that submits on May 31st, 2006 be merged in by reference, and 957 and the novel application No.11/516 of U.S. utility that submitted in 6th in JIUYUE in 2006,456 priority.
Background technology
Showed already that the strictness control for insulin administration in type i diabetes (being generally young hair style) and type ii diabetes (being generally the late hair style of adult) had improved these patients' quality of life and holistic health level.The administration of insulin is to implement so that diet is compensated with the basic needs that satisfy the patient and by short-acting insulin by the subcutaneous injection protamine zine insulin.Recently, the development of electronic external insulin infusion pumps has allowed at the lasting transfusion of keeping the Semilente Insulin that the basis needs and at the compensation dosage of diet.These transfusion systems have demonstrated the control that has improved blood sugar level, yet they but have the shortcoming of size, cost and complexity aspect, and these shortcomings have hindered a lot of patients to accept the hypodermoclysis of this technology with alternate standard.Basis and the pre-meal insulin with the supply aequum controlled and need be programmed to these pumps electronically.
Therefore, in this technical field, exist to be used for basis needs and need before the meal, the simple demand of Mechanical Driven infusion set, this infusion set directly is attached to health and and without any need for electronic device medicine-feeding rate is programmed.Be similar to prior art, preferably insulin be transported in the subcutaneous tissue by skin by little, sheet-metal duct (sleeve pipe).The present invention, in its various embodiment, purpose provides such device.
Summary of the invention
The invention provides a kind of infusion set of wearing, it comprises: the base portion of contact patient skin; And reservoir, this reservoir is arranged to hold the liquid medicine with carrying below patient skin.This reservoir has outlet, and medicine flows by this outlet.This device also comprises flexible conduit that is communicated with the outlet of reservoir and the pump that causes medicine to flow down along conduit.
Described pump is arranged to act on conduit so that makes drug flow.This device also can comprise the valve of the upstream that is positioned at pump, and when described pumping action during in conduit, this valve blocks conduit with respect to reservoir.Described pump can be a peristaltic pump, comprises linear peristaltic pump.
This device also can comprise a pair of relative actuation button that is coupled to described pump, and when side by side being depressed, this actuation button causes described pumping action consequently medicine to be flowed down along conduit on conduit.
This device also can comprise the spring that is associated with each actuation button, and this spring is biased to the starting position with actuation button.Described pump can comprise at least one press member that conductive pipe is exerted pressure, and this at least one press member can be integrally formed into an actuation button.Described pump can comprise a pair of press member that the opposite side of conductive pipe is exerted pressure.Each press member all can be integrally formed into an actuation button.On the preferably elongated and opposite side that be placed in conduit of press member.Press member can for example separate from conduit on the opposite side of conduit, and along the direction of reservoir in more close gradually mode at interval.
This device also can comprise and prevents medicine check-valves that reflux, that be positioned at described pump downstream.This device also can comprise the actuator that activates described pump, and this check-valves can be arranged to cut out in response to actuator.Check-valves can be coupled to actuator.Cause after fluid medicine flows at described pump, the check-valves that is positioned at described pump downstream can closure catheter for closing drip from reservoir to prevent medicine.
In another embodiment, the invention provides a kind of infusion set of wearing, it comprises: the base portion of contact patient skin; Reservoir is arranged to hold the liquid medicine with carrying, and has outlet below patient skin, medicine flows by this outlet; With the flexible conduit that is communicated with the outlet of reservoir.This device also comprises the peristaltic pump that acts on the conduit so that medicine is flowed down along conduit, and causes peristaltic pump to act on supravasal a pair of actuation button when side by side being depressed.
This device also can comprise and prevents medicine check-valves that reflux, that be positioned at the peristaltic pump downstream.Check-valves can be coupled at least one actuation button.Peristaltic pump can comprise a pair of press member on the opposite side that places conduit.Press member can be elongated, on the opposite side of conduit, separates from conduit, and along the direction of reservoir in more close gradually mode at interval.Each press member all can be plastics and with the relevant actuation button part that forms as one.This device also can comprise the spring that is associated with each actuation button, and this spring is used for actuation button is biased to the starting position.
Brief Description Of Drawings
In claims, elaborated the novel characteristics that is considered to of the present invention.By combining with accompanying drawing following explanation is carried out with reference to understanding further feature and the advantage of the present invention together with it best, among several secondary figure in described accompanying drawing, same reference number identifies components identical, and wherein:
Fig. 1 is the perspective view that embodies infusion set of the present invention;
Fig. 2 is the perspective view of Fig. 1 device, and wherein its top cover is removed and is in and prepares to utilize in the state of its reservoir of liquid medicine filling;
Fig. 3 be Fig. 1 infusion set after its reservoir is filled by liquid medicine perspective view, wherein its top cover is removed;
Fig. 4 is Fig. 1 infusion set, the cut perspective view of some parts, illustrates the path of liquid medicine in this device;
Fig. 5 is the top view of Fig. 1 device, and wherein its reservoir is removed, and is used for signal and causes liquid medicine in the mobile mode of this device;
Fig. 6 is the perspective view of Fig. 1 infusion set, and wherein its reservoir is removed, and is used to illustrate its others of pump;
Fig. 7 is the perspective view of the cut Fig. 1 infusion set of some parts, is used for illustrating being in the safety check-valves of its open position;
Fig. 8 is the perspective view that is similar to Fig. 7, illustrates the safety closure of check ring;
Fig. 9 is the perspective view that can be used for the reservoir of Fig. 1 infusion set according to alternate embodiments; And
Figure 10 is the cut perspective view of the some parts of Fig. 9 reservoir, is used to illustrate according to of the present invention, its others.
The specific embodiment
With reference now to Fig. 1,, its signal embodies infusion set 100 of the present invention.For example, for example insulin is when carrying below patient skin in that heavy dose of liquid medicine is provided, and infusion set 100 can be useful.
As can find out ground in Fig. 2, device 100 also comprises a pair of actuation button 120 and is positioned to receive the reservoir 140 of liquid medicine.As seeing hereinafter, depress actuation button 120 simultaneously and cause the liquid medicine in the reservoir 140 to flow and finally flow to below the patient skin along flexible conduit 150.Utilization turns back to button 120 related springs 122 and 124 of their starting position, each button 120 is carried out spring load.
With reference now to Fig. 3,, when anticipating as shown in FIG. 3 like that, when filling reservoir, tappet 162 moves along with the expansion of reservoir 140.For this reason, reservoir 140 preferably by flexible material for example plastics form, and when being filled, will expand.Tappet 162 moves with rising closed block 164 along with the filling of reservoir 140.When reservoir was filled, closed block 164 was raised in so much, thereby made that block 166 can be at it down through causing to patient's pumping liquid medicine to allow button 120 to be depressed.On the other hand, spring 122 and 124 assists button 122 is turned back to the starting position.
With reference now to Fig. 4,, its signal is when to depressing that actuation button 120 responds and when being pumped, the fluid flow path of liquid medicine.With dashed lines in Fig. 4 (dashed line) illustrates fluid flow path.As can be noted, the fluid flow from reservoir 140 starts from outlet 144 along flexible conduit 148.Utilize pump, the linear peristaltic pump 170 that for example will be described below comes the propulsive fluid medicine.It at first flows through valve 180, and valve 180 can be configured to when pump 170 pumping fluid medicines pump 170 be isolated from reservoir 140.Valve 180 is alternatively in some cases, for example when as will be hereinafter fully as described in, when using the linear peristaltic pump of described type here.
Thereby fluid continues along flexible conduit 148 mobile sleeve pipe 200 places that finally arrive.It is fed to the patient below patient skin then.
Fig. 5 and 6 illustrates the peristaltic pump of device 100 in further detail.Here, as can be seen, this peristaltic pump comprises a pair of press member 172 and 174.Press member 172 and 174 is placed on the opposite side of flexible conduit 148.Utilization is along the arrow 149 signal fluid flow directions away from the direction of reservoir (not shown).Press member 172 and 174 separates, thus with respect to fluid flow towards updrift side, they become little by little more close.Therefore, when press member 172 and 174 acted on the flexible conduit 148, they will be used at first clamping flexible conduit made its closure, and then, when applying other pressure, the extrusion conduit is to oppress liquid medicine along downstream direction.
As previously mentioned, valve 180 is alternatively.If the pump that is utilized be not at first closure catheter for closing as here the signal pump, then valve 180 can be coupled to actuation button 120, thereby is utilizing pump before exerting pressure on the flexible conduit 148, valve 180 closure catheter for closing 148.For this reason, valve 180 comprises first valve part 182 and the second fixed valve parts 184.When depressing actuation button 120, valve part 182 pivots around pivotal point 186 and makes its closure to clamp flexible conduit near fixed part 184.
In Fig. 6, can be clear that more that each press member 172 all is integrally formed into a relevant actuation button 120 with 174.More specifically, each press member all can be formed integral piece with its actuation button 120.Because intention device 100 is disposable, actuation button and therefore press member 172 and 174 can form by plastics.
In case actuation button 120 is depressed and peristaltic pump 170 causes liquid medicine to flow downward along flexible conduit 148, actuation button 120 is turned back to their starting position by their springs 122 and 124 separately.At this moment, flexible conduit 148 is fluid-filled to cause fluid medicine to leave sleeve pipe 190, as shown in FIG. 4 meaning.In order to resist the back pressure in sleeve pipe 190 and the flexible conduit, otherwise this will reduce the amount of the liquid medicine that is received by the patient, and check-valves 190 is provided.Check-valves 190 is positioned at the downstream of pump 170 and carries out two kinds of functions at least.At first, check-valves 190 prevents when cutting out that medicine from refluxing and guarantees that from the check-valves to the sleeve pipe medicine in 200 the flexible conduit finally spreads in patient's body.It prevents that also the liquid medicine accident is leaked in patient's body between the actuating of button 120.
Especially with reference to figure 7 and 8, in Fig. 7, can notice, utilize the shut-off block 192 that is coupled to actuation button 120 at tie-point 194 places to form valve 190.When actuation button 120 was side by side depressed, shut-off block 192 slided into the position of illustrating among Fig. 7 and arrives open position, to allow fluid flow by flexible conduit 148.As can in Fig. 8, seeing, when actuation button 120 is released, cause shut-off block 192 to move, and finally between shut-off block 192 and fixation wall 196, clamp flexible conduit 148 and make its closure along direction towards flexible conduit 148.In case valve 190 is closed as shown in Figure 8, will allow liquid medicine unexpectedly to drip, flow through conduit, and be transported to the patient from reservoir.
With reference now to Fig. 9 and 10,, they illustrate the alternative flexible reservoir that can be used to according in the infusion pump of the present invention.Flexible reservoir 240 is formed by flexible sheet material, comprises thin slice 242 and thin slice 244. Sheet material 242 and 244 sealed along peripheral seal line 246.Notice that as can in Fig. 9 and 10, knowing reservoir 240 is shaped as and is forming formation raised portion 250 on raised portion 248 and the opposite side at reservoir on reservoir one side.Raised portion 248 and 250 can be the pointed regions with concave side walls.For example, pointed regions 248 has concave side walls 249 and pointed regions 250 has concave side walls 251.
When reservoir 240 is placed in infusion set for example in the infusion set 100 of Fig. 1 the time, it can so be put, and makes to raise zone 250 and 248 along the limit with basic stay (pane).Put the zone 250 that becomes to make to raise when being positioned at regional 248 tops of rising when reservoir 240, will form air pocket in reservoir 240, for example air pocket 253.Air pocket 253 will be captured in the liquid medicine that just is being transported to the patient without any air with assurance with outlet 256 isolation.
Therefore, as finding out ground from aforementioned, the invention provides a kind of simple, Mechanical Driven infusion set, this infusion set provides for example insulin of heavy dose of liquid medicine, and can directly be attached to patient body.This device also comes administration or drug conveying is programmed without any need for electronic device.As known in the art, can by small casing with liquid medicine for example insulin be transported in patient's the subcutaneous tissue.
Though illustrated and described specific embodiments of the invention, can modify, and therefore in claims expectation contain and fall into as by the true spirit of the present invention that those claim limited and all this change and the modification of scope.
Claims (42)
1. can wear infusion set for one kind, comprise
The base portion of contact patient skin;
Be positioned to receive the reservoir of the liquid medicine that will carry below patient skin, this reservoir has outlet, and medicine flows by this outlet;
The flexible conduit that is communicated with the outlet of reservoir; With
The pump that causes medicine to flow down along conduit.
2. according to the device of claim 1, wherein said pumping action consequently makes drug flow on conduit.
3. according to the device of claim 2, also comprise the valve of the upstream that is positioned at described pump, when described pumping action was on conduit, this valve blocked conduit with respect to reservoir.
4. according to the device of claim 2, wherein said pump is a peristaltic pump.
5. according to the device of claim 4, wherein said peristaltic pump comprises linear peristaltic pump.
6. according to the device of claim 1, also comprise a pair of relative actuation button that is coupled to described pump, when side by side being depressed, actuation button cause pumping action on conduit so that medicine flow down along conduit.
7. according to the device of claim 6, also comprise the spring that is associated with each actuation button, be used for actuation button is biased to the starting position.
8. according to the device of claim 6, wherein said pump comprises at least one press member that conductive pipe is exerted pressure, and this at least one press member and an actuation button are integrally formed into.
9. according to the device of claim 6, wherein said pump comprises a pair of press member that the opposite side of conductive pipe is exerted pressure, and wherein each press member all is integrally formed into an actuation button.
10. according to the device of claim 9, wherein said press member is elongated and is placed in the relative both sides of conduit.
11. according to the device of claim 10, wherein said press member is spaced apart at the relative both sides and the conduit of conduit, and in more close gradually mode at interval along the direction of reservoir.
12. according to the device of claim 11, wherein each press member and relevant actuation button thereof form by plastics.
13., also comprise preventing medicine check-valves that reflux, that be positioned at described pump downstream according to the device of claim 1.
14. according to the device of claim 13, also comprise the actuator that activates described pump, and wherein said check-valves cuts out in response to actuator.
15. according to the device of claim 14, wherein said check-valves is coupled to actuator.
16. according to the device of claim 1, also comprise the check-valves that is positioned at described pump downstream, described check-valves causes the mobile closure catheter for closing afterwards of fluid medicine at described pump, drips from reservoir to prevent medicine.
17. according to the device of claim 16, also comprise the actuator that activates described pump, and wherein said check-valves cuts out in response to actuator turns back to the starting position.
18. according to the device of claim 14, wherein said check-valves is coupled to actuator.
19. can wear infusion set, comprise for one kind:
The base portion of contact patient skin;
Be positioned to receive the reservoir of the liquid medicine that will carry below patient skin, this reservoir has outlet, and medicine flows by this outlet;
The flexible conduit that is communicated with the outlet of reservoir;
Act on the conduit so that the peristaltic pump that medicine flows down along conduit; With
A pair of actuation button, when being depressed simultaneously, described actuation button causes peristaltic pump to act on the conduit.
20., also comprise preventing medicine check-valves that reflux, that be positioned at the peristaltic pump downstream according to the device of claim 19.
21. according to the device of claim 20, wherein said check-valves is coupled at least one actuation button.
22. according to the device of claim 19, wherein said peristaltic pump comprises a pair of press member on the relative both sides that place conduit.
23. according to the device of claim 22, wherein said press member is elongated, and is spaced apart at the relative both sides and the conduit of conduit, and in more close gradually mode at interval along the direction of reservoir.
24. according to the device of claim 22, wherein each press member all be plastics and with the relevant actuation button part that forms as one.
25. according to the device of claim 22, each press member of wherein said pump all is integrally formed into an actuation button.
26. according to the device of claim 19, also comprise the spring that is associated with each actuation button, be used for actuation button is biased to the starting position.
27. can wear infusion set, comprise for one kind:
The base portion of contact patient skin;
Be positioned to receive the reservoir of the liquid medicine that will carry below patient skin, this reservoir has outlet, and medicine flows by this outlet;
The conduit that is communicated with the outlet of reservoir;
The pump that causes medicine to flow down along conduit; With
Be connected to a pair of actuation button of described pump, when being depressed simultaneously, described actuation button causes pump to make medicine flow down along conduit.
28. according to the device of claim 27, wherein said actuation button substantially toward each other.
29. device according to claim 27, also comprise the shell that covers base portion, this shell seal reservoir, conduit and pump, wherein said shell has outer surface, and wherein each actuation button all has from the isolating actuation surfaces of described outer surface of outer cover, so that actuation button can be surveyed with tactile manner.
30. according to the device of claim 29, the actuating table of wherein said actuation button and recessed with respect to outer surface of outer cover.
31. according to the device of claim 27, also comprise the valve that is positioned at described pump upstream, when described pump causes medicine when conduit flows down, described valve blocks conduit with respect to reservoir, wherein said valve response is closed in actuation button.
32. according to the device of claim 31, wherein when actuation button was side by side depressed, described valve was closed.
33. according to the device of claim 27, wherein said pump is a mechanical pump.
34., also comprise the valve that is positioned at described pump downstream according to the device of claim 27.
35. according to the device of claim 34, the valve that wherein is positioned at described pump downstream is a check-valves.
36. according to the device of claim 34, the valve that wherein is positioned at described pump downstream is a relief valve.
37. according to the device of claim 34, the valve that wherein is positioned at described pump downstream is arranged to be pressed and activate in response to an actuation button.
38. according to the device of claim 34, the valve that wherein is positioned at described pump downstream is arranged to be pressed and be actuated to open mode in response to an actuation button.
39. can wear infusion set, comprise for one kind
The base portion of contact patient skin, this base portion comprises the binding agent that can be adhered to patient skin;
Be positioned to receive the reservoir of the liquid medicine that will carry below patient skin, this reservoir has outlet, and medicine flows by this outlet;
The conduit that is communicated with the outlet of reservoir;
The pump that causes medicine to flow down along conduit; With
First and second parts, these second parts are on base binder, and first parts are on second tab member, this second parts the inside has sterilization material, described first parts can remove with the exposure sterilization material from second parts, and second parts can remove to expose binding agent from base portion.
40. according to the device of claim 39, wherein said sterilization material comprises ethanol.
41. can wear infusion set, comprise for one kind
The base portion of contact patient skin;
Be positioned to receive the reservoir of the liquid medicine that will carry below patient skin, this reservoir has outlet, and medicine flows by this outlet;
The conduit that is communicated with the outlet of reservoir;
The pump that causes medicine to flow down along conduit;
Cover the shell of base portion, this shell seal reservoir, conduit and pump, wherein said shell has outer surface, and
Be connected at least one actuation button of described pump, when being depressed, described actuation button causes described pump to make medicine flow down along conduit, and described at least one actuation button has from the isolating actuation surfaces of described outer surface of outer cover, so that actuation button can be surveyed with tactile manner.
42. according to the device of claim 41, wherein said actuation surfaces is recessed with respect to outer surface of outer cover.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80995706P | 2006-05-31 | 2006-05-31 | |
| US60/809,957 | 2006-05-31 | ||
| US11/516,456 | 2006-09-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101478957A true CN101478957A (en) | 2009-07-08 |
Family
ID=40839493
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2007800201386A Pending CN101500624A (en) | 2006-05-31 | 2007-05-25 | Disposable infusion device with medicament level indicator |
| CN2007800201668A Active CN101478999B (en) | 2006-05-31 | 2007-05-25 | Cannula delivery apparatus and method for a disposable infusion device |
| CNA2007800201282A Pending CN101478957A (en) | 2006-05-31 | 2007-05-25 | Disposable infusion device with linear peristaltic pump |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2007800201386A Pending CN101500624A (en) | 2006-05-31 | 2007-05-25 | Disposable infusion device with medicament level indicator |
| CN2007800201668A Active CN101478999B (en) | 2006-05-31 | 2007-05-25 | Cannula delivery apparatus and method for a disposable infusion device |
Country Status (1)
| Country | Link |
|---|---|
| CN (3) | CN101500624A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107073205A (en) * | 2014-09-15 | 2017-08-18 | 赛诺菲 | Medicament delivery device with disinfection pad |
| CN111195380A (en) * | 2018-11-20 | 2020-05-26 | 贝克顿·迪金森公司 | Drug delivery device |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2836261B1 (en) | 2012-04-13 | 2020-01-15 | Becton, Dickinson and Company | Infusion device with safety feature for preventing inadvertent activation |
| CA2891227C (en) * | 2012-11-26 | 2021-01-19 | Kci Licensing, Inc. | Combined solution pump and storage system for use with a reduced-pressure treatment system |
| EP3199190B1 (en) * | 2013-09-30 | 2019-12-04 | Medimop Medical Projects Ltd. | Stabilized pen injector |
| US9795534B2 (en) * | 2015-03-04 | 2017-10-24 | Medimop Medical Projects Ltd. | Compliant coupling assembly for cartridge coupling of a drug delivery device |
| WO2018222521A1 (en) | 2017-05-30 | 2018-12-06 | West Pharma. Services IL, Ltd. | Modular drive train for wearable injector |
| MX2020000667A (en) * | 2017-07-18 | 2020-07-29 | Becton Dickinson Co | Administration system, delivery device, and notification device for communicating status of a medical device. |
| CN113244481B (en) * | 2021-05-25 | 2022-07-05 | 吉林大学 | Split type piezoelectricity driven intelligent insulin pastes |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5257980A (en) * | 1993-04-05 | 1993-11-02 | Minimed Technologies, Ltd. | Subcutaneous injection set with crimp-free soft cannula |
| CN2208417Y (en) * | 1994-09-27 | 1995-09-27 | 陕西省科联新技术开发中心 | Hypodermic embedding type medicine infusion device |
| US5851197A (en) * | 1997-02-05 | 1998-12-22 | Minimed Inc. | Injector for a subcutaneous infusion set |
-
2007
- 2007-05-25 CN CNA2007800201386A patent/CN101500624A/en active Pending
- 2007-05-25 CN CN2007800201668A patent/CN101478999B/en active Active
- 2007-05-25 CN CNA2007800201282A patent/CN101478957A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107073205A (en) * | 2014-09-15 | 2017-08-18 | 赛诺菲 | Medicament delivery device with disinfection pad |
| CN111195380A (en) * | 2018-11-20 | 2020-05-26 | 贝克顿·迪金森公司 | Drug delivery device |
| CN111195380B (en) * | 2018-11-20 | 2023-12-22 | 贝克顿·迪金森公司 | Drug delivery device |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101478999A (en) | 2009-07-08 |
| CN101478999B (en) | 2012-09-05 |
| CN101500624A (en) | 2009-08-05 |
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Open date: 20090708 |