CN101439119B - External-use medicament for treating urticaria, eczema and skin pruritus - Google Patents
External-use medicament for treating urticaria, eczema and skin pruritus Download PDFInfo
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- CN101439119B CN101439119B CN2008101438075A CN200810143807A CN101439119B CN 101439119 B CN101439119 B CN 101439119B CN 2008101438075 A CN2008101438075 A CN 2008101438075A CN 200810143807 A CN200810143807 A CN 200810143807A CN 101439119 B CN101439119 B CN 101439119B
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Abstract
An external used medicine for curing urticaria, eczema and cutaneous pruritus comprises the following raw materials according to the parts by weight: 2.5-3.5 parts of pepper, 1.5-2.5 parts of cynanchum paniculatum, 2.5-3.5 parts of broad cocklebur, and 1.5-2.5 parts of macleaya cordata, which can be made into tincture, emulsion, lotion, liniment, pressurized spray, a curd paste or towelette. The medicine has low cost, rapid effect, and has obvious effect on treatment of urticaria, eczema, and cutaneous pruritus.
Description
Background technology
Urticaria is commonly called as " rubella wheal ", is owing to mucocutaneous little vasodilation and permeability increase a kind of localized edema reaction that causes, the people of the 15-20% urticaria of showing effect at least in life a time is arranged.The urticaria characteristics are that red or white welt appear in skin, and that presses fades, break out, and skin lesion appearing without definite location, in time, show when latent, and pruritus is immoderate, leaves no trace after disappearing.Modern medicine is thought urticaria cause of disease complexity, and about 3/4 patient can not find reason.This medicine of the common cause of disease, food, inhalation (inhalatio), infection, physical factor, mosquito bite, Nervous and Mental Factors etc.Urticarial pathogeny is unclear fully as yet, main at present immunity and non-immunity two classes of dividing.Western medical treatment should disease mainly be antiallergic and symptomatic treatment at present.For acute urticaria, antihistaminic commonly used, vitamin C, calcium preparation etc. reduce vascular permeability, and companion stomachache person gives spasmolytic; Pyemia or septicemia causer use the antibiotic control infection.All give symptomatic treatments such as sympathomimetic drug and hormone with shock, laryngeal edema and dyspnea.For chronic urticaria based on the antihistaminic treatment, also useful antifibrinolysin medicine, histaglobin, aprotinin, chloroquine, carbazochrome salicylate, reserpine etc.But the Western medicine curative effect does not significantly exist untoward reaction more, and is easy to recurrence after the drug withdrawal.Much more the traditional Chinese medical science is studied for urticarial treatment, adopt benefiting QI and nourishing blood, dispelling wind for relieving itching and the consolidating superficial resistance that dispels the wind, harmonizing yingfen and weifen method of treatment person to see at present.More doctor family thinks that chronic urticaria hindered by disease QI and blood consumption of a specified duration, or due to weak usually, the insufficiency of vital energy and blood, because of wind syndrome due to blood-deficiency, deficiency of vital energy weakened defensive QI, and disharmony of nutrient QI with defensive QI, the ailment said due to cold or exposure invasion and attack of taking advantage of a weak point in opponent's defence, wind and vital-QI fighting each other is between skin and dermexanthesis.So in treatment, except that dispeling the wind, pay attention to nourishing blood, QI invigorating, consolidating superficial resistance.
Eczema is a kind of allergic skin section disease of obviously oozing out phenomenon that has, and its cause of disease complexity easily repeatedly, is one of difficult and complicated illness of department of dermatologry.It is caused to have the pleomorphism erythra and reach the inflammatory skin reaction of obviously oozing out tendency by multiple internal and external factor, be characterized in violent pruritus, easily shows effect repeatedly and chronicity, generally it is divided into acute, subacute and chronic eczema.The sickness rate of eczema has the trend of rising in recent years, this is not good at abuse, environmental pollution, the disposal of three wastes of chemicals, factors such as rhythm of life is accelerated, stress increasing are relevant, and the pathogeneticing characteristic of eczema is the visible erythema of part or whole body, pimple, blister, erosion, ooze out, incrustation, desquamation, pigmentation etc.
Skin pruritus is a kind of conscious pruritus and do not have the dermatosis of primary lesion clinically.The cause of disease of skin pruritus is not still understood, is thought relevant with some disease, as diabetes, hepatopathy, nephropathy etc. more; Simultaneously also with some extraneous factors stimulate relevant, as cold, warm, chemical ﹠ blended fabric etc.Skin pruritus has the branch of general property and limitation, general the initial skin pruritus of property skin pruritus patient only is confined to a place, and then extend to big of health or whole body gradually, skin pruritus often is that paroxysmal is especially to attach most importance to night, owing to constantly scratch, secondary lesions such as scratch, blood crusts, pigmentation and lichenificationization appear.The limitation skin pruritus betides a certain position of health, and common have pruritus ani, scrotal pruritus, vulval pruritus, a capital pruritus disease etc.Constantly scratching not only can make pachyderma, and has increased the weight of skin pruritus conversely again behind the cortex thickening, therefore can form and more grab more the vicious cycle of itching, more itching and more grabbing.In addition, the patient should not scald the affected part, because the method for scalding can only play temporary transient effect, and not only readily good therapeutic effect, and can aggravate disease.Prescription commonly used for oral administration has Radix Angelicae Sinensis to pick up pain soup, stomach Siberian cocklebur soup, removing dampness pain relieving soup, LONGDAN XIEGAN WAN, coptos bolus for clearing the upper heat, manna disinfecting pills, GUIPI WAN, LIUWEI DIHUANG WAN etc.External the yellow lotion that looses, Cortex Phellodendri LIUYI SAN, Rhizoma Coptidis dermatitis plaster or Radix Sophorae Flavescentis cream arranged.
Above Chinese medicine or Western medicine different curative effects all occurs to the treatment of urticaria, eczema, skin pruritus, have alleviated patient's misery greatly.Weak point is that administration time is long, easily recurrence.
Summary of the invention
The objective of the invention is, at the deficiencies in the prior art part, provide a kind of external used medicine for the treatment of the urticaria, eczema skin pruritus, it is cheap, effect rapidly, treatment urticaria, eczema, skin pruritus effect are remarkable.
Technical scheme of the present invention is that the weight portion raw material composition of the external used medicine of described treatment urticaria, eczema and skin pruritus is:
2.5 parts-3.5 parts in Pericarpium Zanthoxyli,
1.5 parts-2.5 parts of Radix Cynanchi Paniculatis,
2.5 parts-3.5 parts of Herba Xanthiis,
1.5 parts-2.5 parts of Herba Macleayae Cordatae.
The nature,taste and action of Pericarpium Zanthoxyli: suffering, temperature.Warming spleen and stomach for dispelling cold, removing dampness and killing parasites, promoting the circulation of QI to relieve pain.
The nature,taste and action of Herba Xanthii: hardship, suffering, sweet, temperature, slightly poisonous.Diaphoresis is sensible, the wind damp eliminating of loosing, anti-inflammatory analgesic.
The nature,taste and action of Radix Cynanchi Paniculati: suffering, temperature.Removing toxic substances and promoting subsidence of swelling, dredge the meridian passage, pain relieving.
The nature,taste and action of Herba Macleayae Cordatae: hardship, cold, poisonous.Parasite killing, the detoxifcation of dispeling the wind, dissipating blood stasis for subsidence of swelling.
Prescription analysis: be mainly used in diseases such as urticaria, eczema, skin pruritus, energy heat-clearing and toxic substances removing, expelling wind and removing dampness, killing parasites for relieving itching, reducing swelling and alleviating pain.
The preparation of medicine of the present invention is, gets above-mentioned each raw material by described weight portion, adds 4 times of-16 times of water gagings of raw material weight in described raw material, boils and extracts 1 hour-4 hours; Extracting liquid filtering, medicinal residues add 6 times of-12 times of water in addition, boil and extract 1 hour-2 hours, extracting liquid filtering; 2 extracting solution are merged, and centrifugal treating gets supernatant; With gained supernatant concentrating under reduced pressure, obtain that relative density is the extractum of 1.08-1.25 in the time of 45 ℃-60 ℃, preparation process is made pharmaceutical preparation routinely then.
Pharmaceutical preparation of the present invention can be tincture or Emulsion, lotion, liniment, spray etc., can also be wet tissue or curd paste.
The weight ratio of medicine material of the present invention is best the composition: 3 parts in Pericarpium Zanthoxyli, 2 parts of Radix Cynanchi Paniculatis, 3 parts of Herba Xanthiis, 2 parts of Herba Macleayae Cordatae.
Each raw material can be used in root, stem, the leaf any one, preferred stem and leaf.
The clinical efficacy of medicine of the present invention is as follows:
A. case is originated: from the department of dermatologry outpatient service, collect case 72 examples altogether, comprise urticaria, eczema, skin pruritus.Be divided into test group and matched group at random by patient's sequence number of going to a doctor.Wherein Pericarpium Zanthoxyli and Herba Xanthii are organized 38 examples, FUJIENING group 34 examples.Two groups have comparability aspect the integration before sex, age, the course of disease and medication.
B. Therapeutic Method:
Matched group: give FUJIENING complete living or local bathing, every day three times.
Test group: give Pericarpium Zanthoxyli, Herba Xanthii, Radix Cynanchi Paniculati, Herba Macleayae Cordatae lotion whole body or local bathing, every day three times.The drug withdrawal after 7 days of two groups of equal continuous uses, the evaluation curative effect.
C. curative effect observation: press actual methods of marking record:
(1) erythra: no erythra is 0 minute, slight pimple, desquamation or tongue aquatic foodsization, and limitation is 1 minute; Moderate erythema, edema, pimple or tongue aquatic foodsization, being confined to 1 position is 2 minutes; Significantly the tongue aquatic foodsization are distributed in 2 more than the region of anatomy.
(2) pruritus and skin lesion: pruritus and skin secondary lesion scratch, blood crusts, pachylosis disappearance (0 minute); there is not obvious pruritus; patient can stand; do not influence daily life or sleep; the Secondary cases skin lesion disappears more than 80% and does not have irritated 1 minute; the moderate pruritus still can be stood; be intermittence; the time and influence daily routines or sleep; the Secondary cases skin lesion disappears between 30%-80% (2 minutes), and serious pruritus is impatient at, and often influences daily life and sleep; the secondary skin lesion less than 30% that disappears still has during the treatment and increases the weight of (3 minutes).
(3) welt quantity: no welt 0 minute, 1-6 welt 1 minute, 7-12 welt 2 minutes, more than 12 3 minutes.
(4) welt size (maximum gauge): no welt 0 minute, diameter be less than the 0.5cml branch, diameter between 0.5-2.0cm 2 minutes, and diameter was greater than 2.0cm person 3 minutes.
(5) scratch test: feminine gender is 0 minute ,+be 1 minute, 2+ is 2 minutes, 3+ is 3 minutes.
D. curative effect of disease criterion:
The comprehensive therapeutic effect evaluation is that the total mark with pruritus, welt, erythema, General Symptoms and dermatograph test calculates the curative effect rate and judges by level Four.
Curative effect is divided into produce effects, the good effect, and it is invalid effectively to reach.
Symptom integral decline index=[integration before (integration before the treatment-treatment back integration)/treatment] * 100%.
Produce effects: symptom integral decline index 〉=80%
The good effect: symptom integral decline index≤15%
Effectively: symptom integral decline index≤5%
Invalid: symptom integral decline index=0 (no change or increase the weight of is when treatment back integration is decided to be 0 greater than treating foreset timesharing symptom integral decline index)
Total effective rate=obvious effective rate+good the effect
The results are shown in following table:
Pericarpium Zanthoxyli, Herba Xanthii, Radix Cynanchi Paniculati, Herba Macleayae Cordatae group obvious effective rate are 4.37%, and total effective rate is that 92.11% FUJIENING matched group is respectively 58.82% and 82.35%.Analyze with Ridit, two groups of there was no significant differences (P〉0.05).
The raw material of the used medicine of above-mentioned clinic observation is formed, 3 parts in Pericarpium Zanthoxyli, 2 parts of Radix Cynanchi Paniculatis, 3 parts of Herba Xanthiis, 2 parts of Herba Macleayae Cordatae, and press the preceding method preparation.
Adopt the raw material of embodiment 2, embodiment 3 to form, also obtain essentially identical clinical efficacy.
As known from the above, the present invention is a kind of external used medicine for the treatment of urticaria, eczema and skin pruritus, and it is cheap, effect rapidly, treatment urticaria, eczema, skin pruritus effect are remarkable.
The specific embodiment
Embodiment 1: get 3 parts in Pericarpium Zanthoxyli, 2 parts of Radix Cynanchi Paniculatis, 3 parts of Herba Xanthiis, 2 parts of Herba Macleayae Cordatae by weight; Each raw material is dropped into reactor, add 10 times of water gagings of raw material weight, boil and extracted 2 hours-3 hours; Extracting liquid filtering, medicinal residues add 8 times of-10 times of water in addition, boil and extract 1 hour-2 hours, extracting liquid filtering; 2 extracting solution are merged, and centrifugal treating gets supernatant; With gained supernatant concentrating under reduced pressure, obtain that relative density is the extractum of 1.08-1.25 in the time of 45 ℃-60 ℃, preparation process is made liniment routinely then.
Embodiment 2: get 5 parts in Pericarpium Zanthoxyli, 1 part of Radix Cynanchi Paniculati, 5 parts of Herba Xanthiis, 1 part of Herba Macleayae Cordatae by weight; Make tincture by example 1 method.
Example 3: get 2 parts in Pericarpium Zanthoxyli, 3 parts of Radix Cynanchi Paniculatis, 2 parts of Herba Xanthiis, 3 parts of Herba Macleayae Cordatae by weight; Make Emulsion by example 1 method.
Claims (2)
1. an external used medicine for the treatment of urticaria, eczema and skin pruritus is characterized in that, its weight portion raw material composition is:
2.5 parts-3.5 parts in Pericarpium Zanthoxyli,
1.5 parts-2.5 parts of Radix Cynanchi Paniculatis,
2.5 parts-3.5 parts of Herba Xanthiis,
1.5 parts-2.5 parts of Herba Macleayae Cordatae.
2. according to the external used medicine of described treatment urticaria, eczema of claim 1 and skin pruritus, it is characterized in that its weight portion raw material composition is: 3 parts in Pericarpium Zanthoxyli, 2 parts of Radix Cynanchi Paniculatis, 3 parts of Herba Xanthiis, 2 parts of Herba Macleayae Cordatae.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101438075A CN101439119B (en) | 2008-12-03 | 2008-12-03 | External-use medicament for treating urticaria, eczema and skin pruritus |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101438075A CN101439119B (en) | 2008-12-03 | 2008-12-03 | External-use medicament for treating urticaria, eczema and skin pruritus |
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| Publication Number | Publication Date |
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| CN101439119A CN101439119A (en) | 2009-05-27 |
| CN101439119B true CN101439119B (en) | 2011-07-20 |
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| CN2008101438075A Expired - Fee Related CN101439119B (en) | 2008-12-03 | 2008-12-03 | External-use medicament for treating urticaria, eczema and skin pruritus |
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| CN104873654A (en) * | 2015-06-05 | 2015-09-02 | 徐艳 | Pharmaceutic preparation for treating urticaria |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1081818A (en) * | 1993-06-13 | 1994-02-16 | 龚高烈 | Insecticide for plant and production method |
| CN1304660A (en) * | 2000-11-16 | 2001-07-25 | 田国祥 | Liquid insecticide as agricultural chemical prepared from natural plant and its preparing process |
| CN1425460A (en) * | 2003-01-06 | 2003-06-25 | 贵州奥秘药业有限公司 | External use macleaya cordata tincture for curing skin pruritus |
| CN1740175A (en) * | 2005-08-29 | 2006-03-01 | 长沙世唯科技有限公司 | Plumepoppy total alkaloid salt and its prepn and application |
-
2008
- 2008-12-03 CN CN2008101438075A patent/CN101439119B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1081818A (en) * | 1993-06-13 | 1994-02-16 | 龚高烈 | Insecticide for plant and production method |
| CN1304660A (en) * | 2000-11-16 | 2001-07-25 | 田国祥 | Liquid insecticide as agricultural chemical prepared from natural plant and its preparing process |
| CN1425460A (en) * | 2003-01-06 | 2003-06-25 | 贵州奥秘药业有限公司 | External use macleaya cordata tincture for curing skin pruritus |
| CN1740175A (en) * | 2005-08-29 | 2006-03-01 | 长沙世唯科技有限公司 | Plumepoppy total alkaloid salt and its prepn and application |
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