CN101439091B - Agent for nursing eye skin by eliminating and alleviating cell fatigue of eye skin - Google Patents
Agent for nursing eye skin by eliminating and alleviating cell fatigue of eye skin Download PDFInfo
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- CN101439091B CN101439091B CN2008102327667A CN200810232766A CN101439091B CN 101439091 B CN101439091 B CN 101439091B CN 2008102327667 A CN2008102327667 A CN 2008102327667A CN 200810232766 A CN200810232766 A CN 200810232766A CN 101439091 B CN101439091 B CN 101439091B
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Abstract
The invention relates to an eye skin nursing agent for eliminating and relieving fatigue of eye skin cells, and a preparation method thereof. Cucumber and/or white gourd, peppermint leaf, camphor leaf and other natural plants are used as component materials. According to different characteristics of the raw materials, a cell disruption technology is adopted for respectively carrying out crushing, low temperature freezing-centrifuging and sound membrane separation on plant cells so as to obtain a water-soluble preparation. The eye skin nursing agent has a unique formula and a unique preparation method and can relieve and eliminate the states of eye dryness, eye swelling, double image vision, dimness of vision, dark pouches, and the like, which are caused by the fatigue of eye skin as a result of long-time use of the eyes; the eye skin nursing agent can improve the clearness of the vision, prevent and relieve the fatigue of eye skin, promote the metabolization of the eye skin cells and achieve the effects of nursing and moisturizing the eye skin; in addition, the eye skin nursing agent can relieve and amend pouches, false wrinkles of the eyes, and the like, which are caused by the fatigue of the eyes. The eye skin nursing agent has both effectiveness and safety, does not bring accumulated harm to the skin and has a good value in application and generalization.
Description
Technical field
Content of the present invention belongs to field of medicine preparing technology, and relating to a kind of is the eye skin nursing agent that is used to eliminate, alleviate eye skin cell fatigue that raw material is made with the natural fresh medicinal plants, the invention still further relates to the preparation method of this eye skin nursing agent.
Background technology
In recent years, along with modern society's life, work rhythm are accelerated and networked being extensive use of, people significantly increase crowds such as the personnel that especially surf the Net, IT industry practitioner, passenger on long-distance routes's truck man, students with the time of eye.Add up according to interrelated data: China netizen quantity has reached population more than 200,000,000, the netizen for each person every day the surf time on average above 5 hours, administration personnel at different levels surf the Net the office hours every day also above 3 hours, and long-distance transport car driver drives the time average every day especially more than 4 hours, continuous operation sometimes even will be above 6 hours.Because eyes often are absorbed in a place for a long time, people very easily feel the eye visual fatigue, and influence eye healthy and cause one of principal element of all kinds of ocular disease and this fatigue has become so far.
The eye visual fatigue mainly comprises tired two kinds of eyestrain and eye skin cell, and the direct result of the two all is the visual fatigue that causes eye.The most direct performance of eye visual fatigue is that eye is dry and astringent, swelling, ghost image, the dimness of vision, black eye, can occur phenomenons such as eye pouch increases, vision descends, eye wrinkle-removing increases when serious.To solve this class problem mainly be to adopt eye drop in this area in the past, increase the wettability of eyes in view of the above, but it can not solve eye skin cell degree of fatigue at all.In addition, prior art mainly contains eye drop, profit eye dew to the dry and astringent medicine of eyes, though wherein eye drop mainly is that antibiotics class medicine has antiinflammatory, antibacterial action, but it can not play the effect of alleviation eye visual fatigue; It mainly is the medicine of wetting agent one class that profit eye reveals a series products, and all are to the moisture-keeping function of eyes, but can not alleviate visual fatigue.Take a broad view of the ophthalmic medicine of the present list marketing of China, generally only have antiinflammatory, antibiotic, the effect of preserving moisture, still do not have any medicine to consider to alleviate long-time with a visual fatigue problem that causes.
Summary of the invention
The objective of the invention is the problem that prior art exists is solved, and then provide a kind of eye skin nursing agent that can be used for eliminating, alleviating eye skin cell fatigue that utilizes natural plants to make, this eye skin nursing agent has the effect that can effectively alleviate and eliminate because of situations such as dry and astringent, the swelling of eye that the long period causes the eye visual fatigue to cause with eye, ghost image, the dimness of vision, black eye, also has the metabolic capacity that promotes the eye skin cell, the effect that improves salubrious degree, prevention and the sense of elimination visual fatigue of vision; Also has the effect of alleviating and improving because of eye pouch that visual fatigue causes, the false wrinkle of eye etc.
Another object of the present invention provides a kind of preparation method of producing above-mentioned eye skin nursing agent that is exclusively used in.
The technical solution that adopts is to obtain by concentrated the summary on a large amount of scientific experimentss of the designer basis for achieving the above object, it be a kind of based on pharmacology that selected natural plant raw material is carried out health care analytical data and to the eye visual fatigue alleviate, the practical experience of improvement effect and the basis of understanding, adopt the eye skin topical agent of the pure natural that modern biological technology of preparing means are prepared from.The active drug component of this medicament contains the following weight percentages material:
Fructus Cucumidis sativi cell stock solution and/or Fructus Benincasae cell stock solution 85%～90%,
Mentha leave cell stock solution 1%～10%,
Leaf of Camphora cell stock solution 1%～10%,
Borneolum Syntheticum 0.5%～5%.
The main component of eye skin nursing agent of the present invention is Fructus Cucumidis sativi and/or Fructus Benincasae, mentha leave, leaf of Camphora and Borneolum Syntheticum, has been rich in multiple beneficial nutritional labelings such as polysaccharide, polypeptide, Camphora, menthol, trace element in it.In each herbal medicine raw material, effect refrigerant, the aquation cell that Fructus Cucumidis sativi and Fructus Benincasae all have can strengthen eye skin cell hydration capability and metabolic capacity; The effect that mentha leave has is refrigerant, refresh oneself can promote eye skin cell metabolic capacity; Camphora has refreshing effect, and the effect of Borneolum Syntheticum then is refrigerant and is easy to skin to absorb.
The actual dosage form of eye skin nursing agent of the present invention may be made in spray, ointment or the water preparation that is easy to the eye skin and uses, and its preparation method may further comprise the steps:
(1). the preparation of Fructus Cucumidis sativi cell stock solution and/or Fructus Benincasae cell stock solution: will mix with the water of 0.2～0.3 times of weight after fresh Fructus Cucumidis sativi and/or the fresh Fructus Benincasae rough lumber, mixed liquor is put into the ultrasonic cell-break machine, be broken into the cell serosity, after the cell serosity process centrifuge centrifugal treating, get supernatant and separate by the sound film separator again, obtain Fructus Cucumidis sativi cell stock solution and/or the Fructus Benincasae cell stock solution of molecular weight less than 6000D;
(2). the preparation of mentha leave cell stock solution: after new fresh mint leaf smashed with machinery, the water that adds 0.5～0.6 times of weight mixes, mixed liquor is put into the ultrasonic cell-break machine, be broken into the cell serosity, after the cell serosity process centrifuge centrifugal treating, get supernatant and separate by the sound film separator again, obtain the mentha leave cell stock solution of molecular weight less than 6000D;
(3). the preparation of leaf of Camphora cell stock solution: after fresh leaf of Camphora smashed with machinery, the water that adds 0.5～0.6 times of weight mixes, mixed liquor is put into the ultrasonic cell-break machine, be broken into the cell serosity, after the cell serosity process centrifuge centrifugal treating, get supernatant and separate by the sound film separator again, obtain the leaf of Camphora cell stock solution of molecular weight less than 6000D;
(4). after above-mentioned each cell stock solution carried out mixed preparing, in 0～4 ℃ of scope, carry out frozen centrifugation, centrifugal rotational speed 3500rpm, time 15 minutes, remove precipitum, centrifugal liquid is separated through the sound film separator once more, obtains the cell stock solution of molecular weight less than 6000D;
(5). the cell stock solution after the hybrid separation with after Borneolum Syntheticum mixes, is prepared into spray, ointment or water preparation by the preparation method of spray, ointment or the water preparation of the routine of pharmacopeia record with it.
Described eye skin nursing agent of the present invention is the eye skin nursing goods of selecting natural plant material for use and making according to the requirement of biological product technology of preparing, contain vegetable polysaccharides, polypeptide, the cell hydration factor, menthol, Camphora, plurality of active ingredients such as Borneolum Syntheticum, above-mentioned effective ingredient all belongs to low-molecular-weight, be easy to be absorbed by eye part skin, has alleviation, eliminate the effect of eye visual fatigue, it is dry and astringent because of the long eye that causes between using at the moment to have improvement simultaneously, swelling, the dimness of vision, black eye, ghost image, the effect of eye pouch, the eye wrinkle-removing that occurs for middle-aged and elderly people increases, eye pouch forms the effect that also tool has some improvement and prevents to form; In addition, owing to select for use material to be natural plant material in this medicament, do not contain chemical synthetic drug and anaphylactogen material, nontoxic to human body, also without any the eye skin is produced the side effect that sensitization stimulates, collection effectiveness and safety are one, so good use promotional value is arranged.
Alleviate the eye skin is tired for showing eye skin nursing agent of the present invention, the effect of eliminating, the present invention studies by the goods of going through the several years and on probation practice of application repeatedly (comprises that selection eye visual fatigue phenomenon is dry and astringent, swelling, ghost image, the dimness of vision, the test of black eye situation) research process proves, the eye visual fatigue that this eye skin nursing agent has broad spectrum activity improves, alleviate, the effect of eliminating, it is salubrious refreshing to reach the eye vision, visual attention is concentrated, the effect that the moist sense of eye increases promotes the enhancing of eye cellular metabolism ability and blood capillary circulation to strengthen.In the development process, the effectiveness of eye skin nursing agent of the present invention according to because of with longly between at the moment cause that the tired alleviation situation of eye, alleviation eye are dry and astringent, swelling, ghost image, the dimness of vision, black eye degree is standard, produce effects is eliminated according to the eye visual fatigue and the situation elimination is standard, is that the operating position of this eye skin nursing agent of spray is visited to nearly 300 person-times to dosage form, interviewee's using dosage is spray every day one, a using dosage is about 0.5ml, and its statistical result is as follows:
Statistical data is 287 people, and effective percentage is 100%, and obvious effective rate is 96%.
The specific embodiment
Embodiment:
It is as described below that the water miscible solution of eye skin nursing agent spray extracts manufacturing technology steps:
(1). will mix with 0.2 times water after the fresh Fructus Cucumidis sativi rough lumber, mixed liquor is put into the ultrasonic cell-break machine, be broken into the cell serosity, after the cell serosity process centrifuge centrifugal treating (centrifugal rotational speed 3500rpm, time 15 minutes), getting supernatant is that the sound film separator (down with) of ZL03262745.6 separates preparation through the patent No. of designer of the present invention development again, obtain the natural cucumber cell stock solution of molecular weight less than 6000D, color and luster is faint yellow or colourless liquid, includes the vegetable polysaccharides constituents;
(2). will mix with 0.2 times water after the fresh Fructus Benincasae rough lumber, mixed liquor is put into the ultrasonic cell-break machine, be broken into the cell serosity, after the cell serosity process centrifuge centrifugal treating (centrifugal rotational speed 3500rpm, time 15 minutes), get supernatant and separate preparation through the sound film separator again, obtain the natural Fructus Benincasae cell stock solution of molecular weight less than 6000D, color and luster is light green or colourless liquid, includes the vegetable polysaccharides constituents;
(3). after new fresh mint leaf smashed with machinery, the water that adds 0.5 times of weight mixes, mixed liquor is put into the ultrasonic cell-break machine, be broken into the cell serosity, after the cell serosity process centrifuge centrifugal treating (centrifugal rotational speed 3500rpm, time 15 minutes), get supernatant and separate by the sound film separator again, obtain the mentha leave cell stock solution of molecular weight less than 6000D, color and luster is pistac or colourless liquid, contains plant menthol composition;
(4). after fresh leaf of Camphora smashed with machinery, the water that adds 0.5 times of weight mixes, mixed liquor is put into the ultrasonic cell-break machine, be broken into the cell serosity, after the cell serosity process centrifuge centrifugal treating (centrifugal rotational speed 3500rpm, time 15 minutes), get supernatant and separate by the sound film separator again, obtain the leaf of Camphora cell stock solution of molecular weight less than 6000D, color and luster is pistac or colourless liquid, includes plant Camphora constituents;
(5). get above-mentioned each cell stock solution and Borneolum Syntheticum and carry out the raw material configuration by following allocation ratio:
Fructus Cucumidis sativi cell stock solution 4500g,
Fructus Benincasae cell stock solution 4500g,
Mentha leave cell stock solution 500g,
Leaf of Camphora cell stock solution 500g,
Borneolum Syntheticum 100g;
(6). after above-mentioned each cell stock solution by allocation ratio configuration carried out mix, under low temperature (0 ℃～4 ℃) condition, carry out high speed centrifugation (centrifugal rotational speed 3500rpm, time 15 minutes), discard residue, keep supernatant, supernatant adopts the sound film isolation technics to separate, and obtains the separating medium of molecular weight less than 6000D;
(7). with after Borneolum Syntheticum mixes, the preparation method of spray gives packing and packing after it is prepared into spray routinely, gets product with the cell stock solution after the hybrid separation.
Claims (2)
1. eye skin nursing agent that is used to eliminate, alleviate eye skin cell fatigue, it is characterized in that it is is that the dosage form that raw material is made is the eye skin topical agent of spray, ointment or water preparation by Fructus Cucumidis sativi and/or Fructus Benincasae, mentha leave, leaf of Camphora and Borneolum Syntheticum, the active drug component of this medicament contains the following weight percentages material:
Fructus Cucumidis sativi cell stock solution and/or Fructus Benincasae cell stock solution 85%～90%,
Mentha leave cell stock solution 1%～10%,
Leaf of Camphora cell stock solution 1%～10%,
Borneolum Syntheticum 0.5%～5%.
2. method that is used to prepare the described eye skin nursing of claim 1 agent is characterized in that comprising following preparation process:
A. the preparation of Fructus Cucumidis sativi cell stock solution and/or Fructus Benincasae cell stock solution: will mix with the water of 0.2～0.3 times of weight after fresh Fructus Cucumidis sativi and/or the fresh Fructus Benincasae rough lumber, mixed liquor is put into the ultrasonic cell-break machine, be broken into the cell serosity, after the cell serosity process centrifuge centrifugal treating, get supernatant and separate by the sound film separator again, obtain Fructus Cucumidis sativi cell stock solution and/or the Fructus Benincasae cell stock solution of molecular weight less than 6000D;
B. the preparation of mentha leave cell stock solution: after new fresh mint leaf smashed with machinery, the water that adds 0.5～0.6 times of weight mixes, mixed liquor is put into the ultrasonic cell-break machine, be broken into the cell serosity, after the cell serosity process centrifuge centrifugal treating, get supernatant and separate by the sound film separator again, obtain the mentha leave cell stock solution of molecular weight less than 6000D;
C. the preparation of leaf of Camphora cell stock solution: after fresh leaf of Camphora smashed with machinery, the water that adds 0.5～0.6 times of weight mixes, mixed liquor is put into the ultrasonic cell-break machine, be broken into the cell serosity, after the cell serosity process centrifuge centrifugal treating, get supernatant and separate by the sound film separator again, obtain the leaf of Camphora cell stock solution of molecular weight less than 6000D;
D. after above-mentioned each cell stock solution being carried out mixed preparing, in 0～4 ℃ of scope, carry out frozen centrifugation, centrifugal rotational speed 3500rpm, time 15 minutes, remove precipitum, centrifugal liquid is separated through the sound film separator once more, obtains the cell stock solution of molecular weight less than 6000D;
E. with the cell stock solution after the hybrid separation with after Borneolum Syntheticum mixes, by the preparation method of spray, ointment or water preparation it is prepared into spray, ointment or water preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008102327667A CN101439091B (en) | 2008-12-22 | 2008-12-22 | Agent for nursing eye skin by eliminating and alleviating cell fatigue of eye skin |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008102327667A CN101439091B (en) | 2008-12-22 | 2008-12-22 | Agent for nursing eye skin by eliminating and alleviating cell fatigue of eye skin |
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| CN101439091A CN101439091A (en) | 2009-05-27 |
| CN101439091B true CN101439091B (en) | 2011-04-27 |
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| CN2008102327667A Active CN101439091B (en) | 2008-12-22 | 2008-12-22 | Agent for nursing eye skin by eliminating and alleviating cell fatigue of eye skin |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104095927A (en) * | 2013-04-08 | 2014-10-15 | 韦建学 | Eye refreshing agent used for eliminating and alleviating eye fatigue and malaise |
| CN106974876A (en) * | 2017-03-14 | 2017-07-25 | 天津喜诺生物医药有限公司 | A kind of method that eye care solution is prepared by horseshoe crab cell pyrolysis liquid |
| CN108272686A (en) * | 2018-03-30 | 2018-07-13 | 徐文豪 | A kind of sunflower oil massage emulsion |
Citations (4)
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|---|---|---|---|---|
| CN1293557A (en) * | 1998-03-24 | 2001-05-02 | 荷兰联合利华有限公司 | Moistened cosmetic eye treatment pads |
| CN1317334A (en) * | 2000-04-10 | 2001-10-17 | 王振利 | Ointment for treating myopia and its preparing process |
| CN2638833Y (en) * | 2003-09-09 | 2004-09-08 | 韦建学 | Acoustic membrane separator |
| CN101062002A (en) * | 2006-04-24 | 2007-10-31 | 王筑平 | Skin-care combination including plant extracts |
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2008
- 2008-12-22 CN CN2008102327667A patent/CN101439091B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1293557A (en) * | 1998-03-24 | 2001-05-02 | 荷兰联合利华有限公司 | Moistened cosmetic eye treatment pads |
| CN1317334A (en) * | 2000-04-10 | 2001-10-17 | 王振利 | Ointment for treating myopia and its preparing process |
| CN2638833Y (en) * | 2003-09-09 | 2004-09-08 | 韦建学 | Acoustic membrane separator |
| CN101062002A (en) * | 2006-04-24 | 2007-10-31 | 王筑平 | Skin-care combination including plant extracts |
Non-Patent Citations (2)
| Title |
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| 开心鱼.美目的内外玄机.《中国女性》.2006,(第3期),第106-107页. * |
| 邵娟.精心呵护,老眼不昏花.《现代养生》.2004,(第12期),第11-12页. * |
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Effective date of registration: 20190301 Address after: 710304 No. 6 Building 2-4-2, Accelerator Park, No. 2, Caotang Qinling Avenue, Xi'an High-tech Zone, Shaanxi Province Co-patentee after: Wei Jianxue Patentee after: Shaanxi Liang emperor Biotechnology Co., Ltd. Address before: 710004 No. 11 Dawn Second Lane, Xiba Road, Xi'an City, Shaanxi Province Patentee before: Wei Jianxue |
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