CN101439057A - Chinese medicine granule containing gingko extract and preparation method thereof - Google Patents
Chinese medicine granule containing gingko extract and preparation method thereof Download PDFInfo
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- CN101439057A CN101439057A CNA2007101503027A CN200710150302A CN101439057A CN 101439057 A CN101439057 A CN 101439057A CN A2007101503027 A CNA2007101503027 A CN A2007101503027A CN 200710150302 A CN200710150302 A CN 200710150302A CN 101439057 A CN101439057 A CN 101439057A
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- semen ginkgo
- ginkgo extrac
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Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides a traditional Chinese medicine granular preparation with ginkgo biloba extract and a preparation method thereof. Traditional Chinese medicine spheroidized particles are prepared by using the ginkgo biloba extract and a pharmaceutically acceptable carrier. The shapes of the traditional Chinese medicine spheroidized particles are spherical or similar to spheres, and the density of the traditional Chinese medicine spheroidized particles ranges from 0.6 g/ml to 1.3 g/ml. A single dose of the spheroidized particles is small, the medicine taking is convenient, and the granular preparation can be used as a semifinished product of capsules and can also be used for developing sustained and controlled release preparations of traditional Chinese medicine.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, be specifically related to a kind of Chinese medicinal granule that contains Semen Ginkgo extrac and preparation method thereof.
Background technology
Folium Ginkgo is the leaf of Ginkgoaceae Ginkgo plant Ginkgo biloba (Ginkgobiloba L.).Contain flavonoid (kind surplus in the of about 20), terpenoid, phenols, effective ingredient such as healthy trace elements with household and 17 seed amino acids have and reduce serum cholesterol, coronary blood flow increasing, improve cerebral blood circulation, remove smooth muscle spasm, lax bronchus and pharmacological action such as antibacterial.Not only be applied to treat cardiovascular and cerebrovascular disease clinically, and nervous system, respiratory system etc. is also had good effect.Scientist such as France and Germany is verified, and Folium Ginkgo extract is all having significant curative effect aspect treatment cerebral ischemia, brain injury sequela and the defying age.In recent years, be the health food and the fashionable world of cosmetics that raw material is made with the Folium Ginkgo, only European annual value of production exceedes 5,000,000,000 dollars.Ginkgo is the special product plant of China, and aboundresources accounts for about 70% of world's total amount, and deeply exploitation has vast market prospect.
In recent years, along with people to the going deep into of Folium Ginkgo research, now developed oral liquid, tablet, capsule and electuary at interior a series of preparations.Because dosage form itself, they exist problem: 1. solid orally ingestible (as tablet, capsule etc.) disintegration rate is slow, and the effective ingredient rate of release is low.The disintegrate of solid orally ingestible is the prerequisite of its stripping, and disintegration time is long more, and then the dissolution rate of its effective ingredient is slow more." Chinese Pharmacopoeia 2000 editions " stipulated tablet, the capsule disintegration time should be within an hour.So Chang time for the rapid release of effective ingredient beyond doubt without any helping.2. first pass effect problem.First pass effect (First-pass Effect) claim the first pass effect again, is meant oral drugs after gastrointestinal absorption, at first arrives liver through portal vein, enters the body circulation again.By metabolism, this phenomenon becomes first pass effect to some medicine by liver the time.Oral formulations is because itself, and major part absorbs in gastrointestinal tract, is easy to generate first pass effect, and its effective ingredient is reduced.At the problem of above existence, we need a kind of quick-acting, gingko leaf preparation satisfies the needs of clinical practice efficiently.
The traditional preparation process method of Chinese medicinal granule is to adopt dry method or wet method to make the particulate material of certain particle size Chinese medicine or its extract, when using for the patient with mixing in water for oral taking or swallow.The at present common several granule preparation technologies and the defective of existence thereof: 1. conventional particles preparation technology, because Chinese medical concrete viscosity is higher, there are problems such as particulate drug loading is low, outward appearance is not attractive in appearance, mouthfeel is poor, the easy moisture absorption mostly in the preparation method of conventional particles.2. comparatively popular at present fluidized bed granulation technology, be that drug powder and various adjuvant are packed in the container, be blown into the air-flow of preference temperature by sieve plate from the bed bottom, make material mix homogeneously under fluidized state, begin evenly to spray into binder liq then, powder begins coalescent granulating, through spraying and drying repeatedly, when granular size meets the requirements, stop spraying, continue dry.This technology can be reduced to the adjuvant amount more than 50% by traditional 80%, the single dose of the grain products of preparation generally can be reduced to 3g to 5g by traditional 10g, but this technology can not thoroughly solve the problem of viscosity of Semen Ginkgo extrac, used adjuvant can not further reduce, single agent dose is bigger, and patient's compliance is relatively poor; And use this kind method to be not suitable for making solid preparations such as capsule; Adopting the granule of fluidized bed granulation technology preparation at present commonly used in addition is cellular, irregular shape; Moisture absorption is more common, and inconvenience is preserved; Particulate specific surface area is bigger, is not suitable for coating.3. also having Chinese medicine or plant amedica extract is the research of the micropill technology of 700～1500 μ m with fluidized-bed process manufacturing particle diameter, but this technology all is that medicine is made dry powder, water or other mixing material are as binding agent, add medicine dry powder while spraying into liquid adhesive, make micropill.At present the micropill dissolve scattered time limit that adopts this explained hereafter is generally all at 40 minutes, and defective such as production process is comparatively complicated, cost is high, the influence factor is more (for example can not make when air humidity is big), loss is bigger.4. also have to adopt in formulation art and extrude round or extrude the technology that spheronization is made micropill or spheroidal particle, this technology makes the goods support large usage quantity, and drug loading is general below 25%, and dissolve scattered time limit is more than 30 minutes.5. in formulation art, spray or side pressure spray process at the bottom of the fluid bed of employing are also arranged, make Western medicine micropill or spheroidal particle, be used for the exploitation of slow releasing preparation more, so development product generally has slow controlled release characteristics, do not possess the rapid release characteristic.
The rapid release of Chinese medicine and quick acting are importances of the modernization of Chinese medicine, adopt the Chinese medicine of manufacturing of the present invention or plant amedica granule to have fast instant diffusing characteristic.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicinal granule that contains Semen Ginkgo extrac.
Another object of the present invention is to provide a kind of preparation method that contains the Chinese medicinal granule of Semen Ginkgo extrac.
The Chinese medicinal granule that the present invention contains Semen Ginkgo extrac is achieved through the following technical solutions:
Made by Semen Ginkgo extrac and pharmaceutically acceptable carrier, wherein Semen Ginkgo extrac accounts for 40～90% of percentage by weight, and pharmaceutically acceptable vehicle weight percentage composition is 10～60%.
The present invention contains the Chinese medicinal granule of Semen Ginkgo extrac, preferably is achieved through the following technical solutions:
Weight percentage by Semen Ginkgo extrac is 70～80%, and pharmaceutically acceptable vehicle weight percentage composition is 20～30%.
The present invention contains the Chinese medicinal granule of Semen Ginkgo extrac, and the best is achieved through the following technical solutions:
Weight percentage by Semen Ginkgo extrac is 70～80%, and pharmaceutically acceptable vehicle weight percentage composition is 20～30%.
Semen Ginkgo extrac described in the present invention can get as the preparation of methods such as decocting method, infusion process, percolation, circumfluence method, water extract-alcohol precipitation, alcohol extracting-water precipitating according to present technique field routine or commonly used method; Can be extractum, also can be the effective site of further extraction separation acquisition or the compositions of effective site.
Semen Ginkgo extrac described in the present invention prepares according to following conventional method:
1, water or organic solvent extraction method
The method is domestic and international the most widely used method.Widely used solvent system has ethanol-water (60～70%) or acetone-aqueous solution (50～60%) to carry out lixiviate.Now concrete operation method is summarized as follows:
Ethanol extraction method: dry Folium Ginkgo is pulverized, be immersed in the ethanol,, concentrate and reclaim ethanol, get Folium Ginkgo extract 60 ℃ of reflux; The acetone extraction method: Folium Ginkgo is pulverized, handled about 5h at about 55 ℃ with 60% aqueous acetone solution, cold filtration, filtrate is used CCl
4Extract 3 times, reclaim under reduced pressure acetone gets Folium Ginkgo extract; Water extraction method: dry Folium Ginkgo is pulverized, used water extraction 3h, filter, precipitate with ethanol concentrates and reclaims ethanol, gets Folium Ginkgo extract.
2, water or organic solvent extraction add macropore resin purification method
Because flavone compound and lactone compound less (being respectively about 1.7% and 0.6%) during employing above-mentioned " water or organic solvent extraction method " is extract obtained, therefore must be by the further separation and purification of the extractum that this kind method obtains, the method of purification is a lot, and wherein commonly used is exactly to adopt macroporous adsorbent resin to make with extra care.Hu Min etc. [Wuhan University's journal (natural science edition), 1998,44 (2): 255] have inquired into the principle that solvent extraction and resin adsorption method are made with extra care Folium Ginkgo flavone, and the result shows that the resin absorption process for purification is better than the solvent extraction method for refining.In recent years, mainly the resin that uses is non-polar macroporous resin, as resins such as HP-20, XAD-4, D101.Adopting the main feature of resin adsorption method is that cost is low, the response rate is high, and organic solvent residual is few.
3, supercritical extraction method (SFE method)
The SFE method is the novel method of active component in the separating plant of rising in recent years.It mainly can realize optionally extract and separate, purification by the adding etc. of control temperature, pressure and this property agent.Deng Qizhang etc. [Chinese herbal medicine, 1999,30 (6): 419] have set up a cover supercritical fluid lab scale, pilot-plant and test method, and resulting Folium Ginkgo extract flavones content is 28%, and bilobalide content is 7.2%, all is higher than internationally recognized standard.Compare with organic solvent, have extraction ratio height, no solvent residue, active component and thermally labile component and be difficult for advantages such as destroyed.
4, the high speed adverse current chromatogram extraction method (High Speed Counter CurrentChromatography, HSCCC)
The high speed adverse current chromatogram extraction method is a kind of liquid-liquid partition chromatography technology that need not any immobilization carrier.Cai Dingguo etc. [new Chinese medicine and clinical pharmacology, 1999,10 (1): 44] report adopts the HSCCC technology, separates to have obtained 3 kinds of main glycoside units from Folium Ginkgo.The method has separation rate height to sample, products obtained therefrom concentration height, advantage such as pollution-free, is the preferable means of preparation ginkgo flavonoid glycoside and each bilobalide and bilobalide reference substance.
5, enzyme process
At the contained liposoluble constituent of Folium Ginkgo or be insoluble in the effective ingredient of water, by adding the starch partial hydrolysate glucosyl group residue there are the glucosidase or the transglycosylase of transferance, make fat-soluble or slightly solubility composition or water-fast effective ingredient are transferred in the water-soluble sugar.[Chinese patent medicine such as Li Zhaolong, 1994,16 (10): 52] reported that Japanese height reaches the Gluconase that glucose residue there be transferance with the method by the adding dextrin with the virtue spring, regulated PH2.0, temperature is changeed the sugar reaction for 50 ℃, the effective ingredient that makes the oil-soluble composition and be insoluble in water is transformed into glucoside soluble in water and extracts, heat up then, make enzyme deactivation, supernatant is crossed the HP-20 macroporous adsorbent resin, collect filtrate, be drying to obtain.The active constituent content height that inferior method is extracted, and very easily absorb after changing into glucoside in vivo.
At present, " Chinese pharmacopoeia (2000 editions enlarged editions) has been stipulated the quality standard of Folium Ginkgo extract (GBE), and promptly total flavonoid of ginkgo must not be less than 24%, and bilobalide must not be less than 6%.
Pharmaceutically acceptable carrier of the present invention can be any preparation Chinese medicinal granule pharmaceutically acceptable carrier commonly used or conventional, and for example: diluent (filler) includes but not limited to sucrose, dextrin, starch, lactose, mannitol, xylitol, chitosan, SHUANGQITANG, soluble starch, Pulvis Talci or water solublity dextrin etc.; Disintegrating agent includes but not limited to starch, sodium carboxymethyl cellulose (CMS-Na), microcrystalline Cellulose (MCC), micropowder silica gel, hydroxypropyl starch, soluble starch, water solublity dextrin; Inclusion agents includes but not limited to alpha-cyclodextrin (α-CD), beta-schardinger dextrin-(β-CD) and N-LOK modified starch etc.; Wetting agent (binding agent) includes but not limited to water, ethanol, polyvinylpyrrolidone (polyvidone), hydroxypropyl cellulose, Polyethylene Glycol above-mentioned adjuvant function such as diluent such as (PEG), disintegrating agent, wetting agent is called by function in this patent, be viscosity modifier, preferably microcrystalline cellulose (MCC), micropowder silica gel, Polyethylene Glycol, Pulvis Talci, chitosan, Pulvis Talci, the above-mentioned pharmaceutically acceptable carrier of polyvidone can use separately, also can unite use.Persons of ordinary skill in the art may appreciate that the following emerging pharmaceutically acceptable carrier that can be used for preparing Chinese medicinal granule,, also should be included in protection scope of the present invention if can realize purpose of the present invention.
The present invention contains the Chinese medicinal granule of Semen Ginkgo extrac, and described pharmaceutically acceptable carrier preferably one or more in sucrose, dextrin, starch, lactose, mannitol, xylitol, chitosan, SHUANGQITANG, soluble starch, Pulvis Talci, water solublity dextrin sodium carboxymethyl cellulose (CMS-Na), microcrystalline Cellulose (MCC), micropowder silica gel, hydroxypropyl starch, ethanol, hydroxypropyl cellulose, Polyethylene Glycol, chitosan, polyvidone is united use.
The present invention contains the Chinese medicinal granule of Semen Ginkgo extrac, and described pharmaceutically acceptable carrier is preferably: crystalline cellulose element, micropowder silica gel, Polyethylene Glycol, Pulvis Talci, chitosan, Pulvis Talci, polyvidone.
The present invention contains the Chinese medicinal granule of Semen Ginkgo extrac, described granule comprises master batch and the shell that is positioned on the master batch, and profile is sphere or class sphere, and bulk density is 0.6～1.3g/m, dissolve scattered time limit is 0.4～5 minute, and active constituents of medicine is included among master batch and/or the shell.
The present invention contains the Chinese medicinal granule of Semen Ginkgo extrac, and its particle diameter is 700～1500 μ m.
The present invention contains the Chinese medicinal granule of Semen Ginkgo extrac, and described granule also contains coating, and the weight of coating materials accounts for 2～5wt% of granule gross weight.
The Chinese medicinal granule that the present invention contains Semen Ginkgo extrac adopts the fluidized bed granulation technology to granulate, common fluidized bed granulation technology is directly packed into powdered substance and is granulated as bed material in the container of fluid bed, and the present invention forms with pharmaceutically acceptable preparing carriers, perhaps is prepared from by pharmaceutically acceptable carrier and corresponding Semen Ginkgo extrac dry powder.
The present invention contains the preparation method of the Chinese medicinal granule of Semen Ginkgo extrac, and step is as follows:
(1) it is an amount of to get Semen Ginkgo extrac;
(2) preparation of master batch: i. gets an amount of pharmaceutically acceptable carrier, the perhaps mixture of itself and Semen Ginkgo extrac dry powder, and crushing screening obtains the satisfactory material of granularity; Ii. get the material of a part of step I, drop in spray of fluid bed side or the end spray pot, other gets it filled and learns acceptable carrier and/or Semen Ginkgo extrac and add water and be mixed with slurry, adopt spray of fluid bed side or end pressure spray process to spray into, and sift out granule, again parent nucleus is dropped in the pot as parent nucleus, continue to spray and state slurry, the material of remaining step I is sprinkled into fine powder in the dusting rifle simultaneously, the particle diameter of parent nucleus is grown up, filter out the satisfactory master batch of particle diameter;
(3) preparation of product: it is an amount of to get master batch, and acceptable carrier is an amount of, and Semen Ginkgo extrac is an amount of; Above-mentioned acceptable carrier is added in the above-mentioned Semen Ginkgo extrac, and it is standby as slurry to mix into suspension; Above-mentioned master batch is dropped in the fluid bed side spray pot, and above-mentioned slurry slowly sprays into, and all sprays into to slurry, makes spheroidal particle.
The present invention contains the preparation method of the Chinese medicinal granule of Semen Ginkgo extrac, and preferred steps is as follows:
(1) it is an amount of to get Semen Ginkgo extrac;
(2) preparation of master batch: the mixture of getting dextrin and starch weight ratio and be 1:1 is crossed 200 mesh sieves, and wherein 60-65wt% drops in the fluid bed side spray pot as bed material; 10-15wt% dextrin and starch mixture, amount to the Semen Ginkgo extrac that accounts for the 15wt% of master batch weight after the dry weight, adding water is mixed with slurry and sprays into, and to sift out particle diameter be that 180～250 μ m granules are as parent nucleus, again parent nucleus is dropped in the pot, continue to spray and state slurry, in the dusting rifle dextrin of surplus and the fine powder of starch mixture are sprinkled into simultaneously, the particle diameter of parent nucleus is grown up, the master batch that filters out particle diameter and be 450～600 μ m is standby;
(3) preparation of product: get master batch 450g, the Semen Ginkgo extrac of 300g, with the Semen Ginkgo extrac weight ratio be the polyethylene glycol 6000 of 18:25, be HPMC and the PVP-K30 mixture of 7:25 perhaps with the Semen Ginkgo extrac weight ratio, wherein the HPMC:PVP-K30 weight ratio is 2:5; With dehydrated alcohol above-mentioned viscosity is adjusted and a kind ofly in agent polyethylene glycol 6000 or HPMC and the PVP-K30 mixture to be formulated as the solution that concentration is 15wt%, add in the Semen Ginkgo extrac, after the mixing, adding 60% (ml/ml) ethanol, to transfer to solids content be 19wt%, as slurry; Master batch is dropped in the fluid bed side spray pot, above-mentioned slurry is slowly sprayed into, constantly be dried to slurry simultaneously and all spray into and make spheroidal particle.
The present invention contains in the preparation method of Chinese medicinal granule of Semen Ginkgo extrac, and the temperature of charge of the spheroidal particle that said method can be obtained is controlled at 37～45 ℃; Transparent coating material water is made into the coating solution of 7.5% (g/ml) again, according to the amount of theory weightening finish 3wt% coating solution is sprayed into coating, make spheroidal particle, its bulk density is 0.76g/ml, and dissolve scattered time limit is 25～180 seconds.
The present invention contains in the preparation method of Chinese medicinal granule of Semen Ginkgo extrac, No. 2 capsules of spheroidal particle fill that said method can be obtained, and the 250mg/ grain is made capsule.
" setting of dosage form in the Chinese pharmacopoeia, and in order to distinguish different with technology such as micropill, microcapsules in conjunction with the characteristic of present technique preparing product, was named above-mentioned granule and is spheroidized particle according to version in 2005.
The present invention contains the Chinese medicinal granule of Semen Ginkgo extrac, outside it coating can also be arranged, and the weight of coating materials accounts for the 2-5% of granule gross weight.During the spheroidized particle coating, obviously low (plain particles coating, coating materials consumption are 20-30% to the more common granule coating of the consumption of coating materials, and spheroidized particle coating materials consumption then can be reduced to 2-5% with the adjuvant amount.As required, coating can be common film coating, also can be enteric film coating, slow controlled release coat etc., and coating materials can be the commonly used or conventional coating materials in any this area, select according to different needs, the coating process can be carried out according to the method for this area routine.
The present invention contains the Chinese medicinal granule of Semen Ginkgo extrac, directly uses except can be used as common granule, can also be as intermediate, be prepared into dosage forms such as capsule, as granule use etc., can be prepared into sustained-release preparation in addition, positioning release medicine preparation etc.
The present invention contains the Chinese medicinal granule of Semen Ginkgo extrac, and preferred described granule is made conventional capsule agent or sustained-release preparation.
Spheroidized particle of the present invention has the following advantages:
1. the consumption of adjuvant is few, therefore causes single dose little, and the general each dose of patient is that 0.1～4g gets final product, and can reduce the fear that the patient takes medicine and produced heavy dose.
2. outward appearance is good, and granule of the present invention is spherical in shape or class is spherical, the smooth surface rounding, the control of suitable product design quality.
3. physical characteristic is good, and in the spheroidal particle preparation process, mobility of particle is good, causes that particle size distribution is regular, the fine and close anti-extruding of quality, and wear-resistant, density is big, and (bulk density is 0.6～1.3g/ml), specific surface area is little (has only 0.01～0.03m
2/ g).
4. dissolve scattered time limit is short, and the spheroidal particle dissolve scattered time limit of the present invention that adopts this type of prescription to make is short, is generally 0.4～5 minute.
5. granularity test: according to 2000 editions pharmacopeia regulations, get granule 5 bags of (bottle) or multiple dose packing granule 1 bags (bottle) of single dose packing, claim to decide weight, put in the medicine sieve and sieve.When sieving, will sieve and keep level, about come and go and sieved gently 3 minutes.Can not and can must not cross 8.0% by a sieve by the granule and the powder summation of No. four sieves.Granule of the present invention can not and can meet the pharmacopeia regulation by the granule and the powder summation of No. four sieves by a sieve, and its numerical value is no more than 5.5%.
6. melting test: according to 2000 editions pharmacopeia regulations, get medicinal granule test sample 10g of the present invention, add 20 times of hot water, stirred 5 minutes, observe immediately.Soluble granule is answered off-bottom.
These characteristics can improve patient's the row of complying with, and makes the application of packaging technique become possibility, thereby has solved the moisture absorption (critical wettability is promoted to 85% by 60% of plain particles) of Chinese medicine, problem such as stable; In addition, spheroidized particle of the present invention uses except can be used as common granule, can also be as intermediate or granule, and fill becomes dosage forms such as capsule, can be prepared into sustained-release preparation in addition, positioning release medicine preparation etc.
The specific embodiment
The present invention is further illustrated below in conjunction with specific embodiment, and following this embodiment only is used to the present invention is described and to the present invention without limits.
Embodiment 1
The preparation of Folium Ginkgo extract: get the 10000g Folium Ginkgo and pulverize, measure acetone with 5 times: water (70:30) mixed liquor heating extraction 2 times, each 2 hours, temperature was 50～60 ℃, and merge extractive liquid, filters, and concentrating under reduced pressure becomes Folium Ginkgo extract;
The preparation of master batch: the weight ratio of getting dextrin and starch is crossed 200 mesh sieves for the 1:1 mixture, wherein 65% as in the bed material input fluid bed side spray pot, other gets starch and adds water and be mixed with starch slurry (15%) and spray into as slurry, and sift out granule (particle diameter is 180-250 μ) as parent nucleus, again parent nucleus is dropped in the pot, continue the spray starch slurry, 35% the dextrin of remainder and the fine powder of starch are sprinkled in the dusting rifle simultaneously, the particle diameter of parent nucleus is grown up, and it is standby at the master batch of 450 μ-600 μ to filter out particle diameter.
The preparation of product: get master batch 450g, microcrystalline Cellulose (200 order) 50g, polyethylene glycol 6000 (heating and melting)
500G, Semen Ginkgo extrac 320g; Microcrystalline Cellulose and micropowder silica gel are added in the Semen Ginkgo extrac, and adding water, to mix into solid content be 30% binding agent; Master batch is dropped in the fluid bed side spray pot, slurry is slowly sprayed into, constantly being dried to simultaneously slurry all sprays into and makes spheroidal particle, temperature of charge is controlled at 55 degrees centigrade, coating material OPAGLOS 2 waters that reuse is transparent are made into 7.5% coating solution, amount according to theory weightening finish 3% sprays into coating with coating solution, makes spheroidal particle.
Embodiment 2
The preparation of Folium Ginkgo extract: get the 10000g Folium Ginkgo and pulverize, add 5 times of amount 65% alcohol reflux 2 times, each 2 hours, temperature was 60 ℃, and merge extractive liquid, filters, and concentrating under reduced pressure reclaims ethanol and gets Folium Ginkgo extract;
The preparation of master batch: the mixture of getting micropowder silica gel and chitosan weight ratio and be 1:1 is crossed 200 mesh sieves, wherein 65% as in the bed material input fluid bed side spray pot, other gets PVP K30 and adds water, extract, is mixed with bonding agent-spray into as slurry, and to sift out particle diameter be that 120-180 μ granule is as parent nucleus, again parent nucleus is dropped in the pot, continue the spray starch slurry, 35% the micropowder silica gel of remainder and the fine powder of chitosan are sprinkled in the dusting rifle simultaneously, the particle diameter of parent nucleus is grown up, and it is standby at the master batch of 200 μ-300 μ to filter out particle diameter.
The preparation of product: get master batch 300g, microcrystalline Cellulose (200 order) 250g, micropowder silica gel 14g, Semen Ginkgo extrac 200g; Microcrystalline Cellulose and micropowder silica gel are added in the Semen Ginkgo extrac, and it is standby as slurry to mix into uniform suspension; Master batch is dropped in the fluid bed side spray pot, slurry is slowly sprayed into, constantly be dried to simultaneously slurry and all spray into and make spheroidal particle, coating material OPAGLOS 2 waters that reuse is transparent are made into 7.5% coating solution, amount according to theory weightening finish 3% sprays into coating with coating solution, makes spheroidal particle.
Embodiment 3
The preparation of Folium Ginkgo extract: get the 1000g Folium Ginkgo, add the water of 5 times of amounts, decoct each 2 hours 2 times, temperature is 50～60 ℃, and merge extractive liquid, concentrates, and it is refining to cross macroporous adsorbent resin (AB-8), use 80% ethanol elution, eluent concentrates and reclaims ethanol, gets Folium Ginkgo extract;
The preparation of master batch: the mixture of getting dextrin and starch weight ratio and be 1:1 is crossed 200 mesh sieves, wherein 65% as in the bed material input fluid bed side spray pot, other gets starch, extract (account for after giving money as a gift master batch weight 15%) and adds water and be mixed with slurry and spray into, and sift out granule (particle diameter is 180～250 μ) as parent nucleus, again parent nucleus is dropped in the pot, continue the spray starch slurry, 35% the dextrin of remainder and the fine powder of starch are sprinkled in the dusting rifle simultaneously, the particle diameter of parent nucleus is grown up, and it is standby at the master batch of 300 μ～400 μ to filter out particle diameter.
The preparation of product: get master batch 450g, microcrystalline Cellulose (200 order) 50g, polyethylene glycol 6000 (heating and melting)
500G, Semen Ginkgo extrac 1000g; Microcrystalline Cellulose and micropowder silica gel are added in the Semen Ginkgo extrac, and adding water, to mix into solid content be 30% binding agent; Master batch is dropped in the fluid bed side spray pot, slurry is slowly sprayed into, constantly being dried to simultaneously slurry all sprays into and makes spheroidal particle, temperature of charge is controlled at 55 degrees centigrade, coating material OPAGLOS 2 waters that reuse is transparent are made into 7.5% coating solution, amount according to theory weightening finish 3% sprays into coating with coating solution, makes spheroidal particle, and bulk density is 0.76g/m1; With No. 2 capsules of spheroidal particle fill that obtain, every dress 0.125g makes 10000 of capsules.
Embodiment 4
The preparation of Folium Ginkgo extract: get the 10000g Folium Ginkgo, add 5 times of amount 65% ethanol, heating and refluxing extraction 2 times, each 1 hour, 60 ℃ of temperature, merge extractive liquid, concentrates, and it is refining to cross macroporous adsorbent resin (D101), use 85% ethanol elution, eluent concentrates and reclaims ethanol, gets Folium Ginkgo extract;
The preparation of master batch: the mixture of getting dextrin and microcrystalline Cellulose weight ratio and be 1:1 is crossed 200 mesh sieves, wherein 65% as in the bed material input fluid bed side spray pot, other gets PVP K30 and adds water and be mixed with bonding agent (5%) and spray into as slurry, and to sift out particle diameter be that 180～250 μ granules are as parent nucleus, again parent nucleus is dropped in the pot, continue the spray starch slurry, 35% the dextrin of remainder and the fine powder of microcrystalline Cellulose are sprinkled in the dusting rifle simultaneously, the particle diameter of parent nucleus is grown up, and it is standby at the master batch of 300 μ～400 μ to filter out particle diameter.
The preparation of product: get master batch 1000g, add Semen Ginkgo extrac 750g, 5% polyvidone solution, adding water, to mix into solid content be that 30% suspension is standby as slurry; Master batch is dropped in the fluid bed side spray pot, slurry is slowly sprayed into, constantly be dried to simultaneously slurry and all spray into and make spheroidal particle, coating material OPAGLOS 2 waters that reuse is transparent are made into 7.5% coating solution, amount according to theory weightening finish 3% sprays into coating with coating solution, makes spheroidal particle.
Embodiment 5
The preparation of Folium Ginkgo extract: get and pulverize Folium Ginkgo 10000g, adopt CO
2Supercritical extraction gets Folium Ginkgo extract, and process conditions are that temperature is 45 ℃, and extracting pressure is 25Mpa, flow 0.8ml/min, 2 hours time.Ginkgo total flavones 〉=24% wherein, terpene lactones 〉=6%;
The preparation of master batch: the mixture of getting dextrin and microcrystalline Cellulose weight ratio and be 2:1 is crossed 100 mesh sieves, wherein 75% as in the bed material input fluid bed side spray pot, other gets PVP K30 and adds water, extract, is mixed with bonding agent-spray into as slurry, and to sift out particle diameter be that 100-200 μ granule is as parent nucleus, again parent nucleus is dropped in the pot, continue the spray starch slurry, 35% the dextrin of remainder and the fine powder of microcrystalline Cellulose are sprinkled in the dusting rifle simultaneously, the particle diameter of parent nucleus is grown up, and it is standby at the master batch of 200 μ-300 μ to filter out particle diameter.
The preparation of product: get master batch 800g, microcrystalline Cellulose 190g, micropowder silica gel 35g, Semen Ginkgo extrac 450g; Microcrystalline Cellulose and micropowder silica gel are added in the Semen Ginkgo extrac, and it is standby as slurry to mix into uniform suspension; Master batch is dropped in the fluid bed side spray pot, slurry is slowly sprayed into, constantly be dried to slurry simultaneously and all spray into and make spheroidal particle.
Embodiment 6
The preparation of Folium Ginkgo extract: getting ginkgo biloba crude extract is raw material, adopts high-speed countercurrent chromatography (HSCCC) preparation Folium Ginkgo extract, adopts the solvent system of chloroform methanol water (4:3:2), after treating that two-phase solvent fully mixes, face with preceding it is separated, at room temperature, make down mobile phase mutually, on the phase that fixes mutually, with the flow velocity of 2.0ml/min, by head end eluting caudad, main frame just changes, and rotating speed is 800r/min, the immobile phase retention is 78%, sample introduction 2.0ml regularly collects fraction, promptly;
The preparation of master batch: the mixture of getting micropowder silica gel and Pulvis Talci weight ratio and be 1:1 is crossed 200 mesh sieves, wherein 50% as in the bed material input fluid bed side spray pot, other gets PVP K30 and adds water, extract, is mixed with bonding agent-spray into as slurry, and to sift out particle diameter be that 120-180 μ granule is as parent nucleus, again parent nucleus is dropped in the pot, continue the spray starch slurry, 35% micropowder silica gel and talcous fine powder of remainder is sprinkled in the dusting rifle simultaneously, the particle diameter of parent nucleus is grown up, and it is standby at the master batch of 200 μ-300 μ to filter out particle diameter.
The preparation of product: get master batch 300g, microcrystalline Cellulose (200 order) 250g, micropowder silica gel 14g, Semen Ginkgo extrac 300g; Microcrystalline Cellulose and micropowder silica gel are added in the Semen Ginkgo extrac, and it is standby as slurry to mix into uniform suspension; Master batch is dropped in the fluid bed side spray pot, slurry is slowly sprayed into, constantly be dried to slurry simultaneously and all spray into and make spheroidal particle.
Embodiment 7
The preparation of Folium Ginkgo extract: adopt enzyme process to make Folium Ginkgo extract;
The preparation of master batch: taking polyethylene glycol and chitosan weight ratio are that the mixture of 1:1 is crossed 200 mesh sieves, wherein 65% as in the bed material input fluid bed side spray pot, other gets PVP K30 and adds water, extract, is mixed with bonding agent-spray into as slurry, and to sift out particle diameter be that 120-180 μ granule is as parent nucleus, again parent nucleus is dropped in the pot, continue the spray starch slurry, 35% the Polyethylene Glycol of remainder and the fine powder of chitosan are sprinkled in the dusting rifle simultaneously, the particle diameter of parent nucleus is grown up, and it is standby at the master batch of 200 μ-300 μ to filter out particle diameter.
The preparation of product: get master batch 700g, microcrystalline Cellulose (200 order) 300g, micropowder silica gel 20g, Semen Ginkgo extrac 430g; Microcrystalline Cellulose and micropowder silica gel are added in the Semen Ginkgo extrac, and it is standby as slurry to mix into uniform suspension; Master batch is dropped in the fluid bed side spray pot, slurry is slowly sprayed into, constantly be dried to slurry simultaneously and all spray into and make spheroidal particle.
Embodiment 8:
1, the preparation of Folium Ginkgo extract: it is an amount of to get the Semen Ginkgo extrac that obtains according to embodiment 1 method;
2, the preparation of master batch: get dextrin and starch (1:1) mixture and cross 200 mesh sieves, wherein 65wt% drops in the fluid bed side spray pot, other gets starch and adds water and be mixed with starch slurry (15%, g/ml) spray into as slurry, and sift out granule (particle diameter is 180～250 μ m) as parent nucleus, again parent nucleus is dropped in the pot, continue to spray and state starch slurry, remaining 35% the dextrin and the fine powder of starch (1: 1) mixture are sprinkled in the dusting rifle simultaneously, the particle diameter of parent nucleus is grown up, and it is standby at the master batch of 450～600 μ m to filter out particle diameter.
3, viscosity is adjusted the selection of agent
A. get above-mentioned Semen Ginkgo extrac, be diluted to the diluent that viscosity is 6.0～9.8MpaS with the alcoholic solution of 60% (ml/ml).
B. get 1 above-mentioned diluent, drop on the microscope slide, hang, solid cicatrix surface, liquid evaporation back does not have complete film, and viscosity is less, easily scrapes with powdery, and it is serious to play powder.
C. the viscosity according to cicatrix among the b is little, film property is poor, intensity is little, easily play characteristics such as powder, select viscosity to adjust agent, experiment shows can select HPMC:PVP-K30 (2:5) mixture to adjust agent as viscosity, and also can select polyethylene glycol 6000 is that viscosity is adjusted agent.
D. selection and Semen Ginkgo extrac weight ratio are that HPMC:PVP-K30 (2:5) mixture of 7:25 is that viscosity is adjusted agent, perhaps selection and Semen Ginkgo extrac weight ratio are that the polyethylene glycol 6000 of 18:25 is that viscosity is adjusted agent, and material viscosity is increased to 16MPaS by 9.0MPaS.
4, the preparation of spheroidal particle of the present invention
A. get master batch 450g, with the Semen Ginkgo extrac weight ratio be the polyethylene glycol 6000 of 18:25, perhaps be HPMC:PVP-K30 (2:5) mixture of 7:25 with the Semen Ginkgo extrac weight ratio, the Semen Ginkgo extrac of 340g;
B. with dehydrated alcohol above-mentioned viscosity is adjusted and a kind ofly in the agent be formulated as the solution that concentration is 5wt%, add in the Semen Ginkgo extrac, after the mixing, adding 60% (ml/ml) ethanol, to transfer to solids content be 19wt%, as slurry;
C. master batch is dropped in the fluid bed side spray pot, above-mentioned slurry is slowly sprayed into, constantly being dried to simultaneously slurry all sprays into and makes spheroidal particle, temperature of charge is controlled at 37～45 ℃, again transparent coating material water is made into the coating solution of 7.5% (g/ml), coating solution is sprayed into coating, make spheroidal particle according to the amount of theory weightening finish 3wt%, its bulk density is 0.76g/ml, and dissolve scattered time limit is 30 seconds.
With No. 2 capsules of spheroidal particle fill that obtain among the step c, the 250mg/ grain is made capsule.
Embodiment 9
1, the preparation of Folium Ginkgo extract: it is an amount of to get the Semen Ginkgo extrac that obtains according to embodiment 2 methods;
2, the preparation of master batch: get xylitol and carboxymethyl starch sodium (1:1) mixture and cross 200 mesh sieves, wherein 60wt% drops in the fluid bed side spray pot, other gets 10wt% xylitol and carboxymethyl starch sodium (1:1) mixture and Semen Ginkgo extrac (after amounting to dry weight, account for the 15wt% of master batch weight) add water and be mixed with slurry and spray into, and sift out granule (particle diameter is 180～250 μ m) as parent nucleus, again parent nucleus is dropped in the pot, continue to spray and state slurry, in the dusting rifle, the xylitol of remaining 30wt% and the fine powder of carboxymethyl starch sodium (1:1) mixture are sprinkled into simultaneously, the particle diameter of parent nucleus is grown up, and the master batch that filters out particle diameter and be 280～450 μ m is standby.
3, the preparation of product: get master batch 450g, the Semen Ginkgo extrac of 440g, with the Semen Ginkgo extrac weight ratio be the polyethylene glycol 6000 of 18:25, with dehydrated alcohol above-mentioned viscosity is adjusted the agent polyethylene glycol 6000 and be formulated as the solution that concentration is 15wt%, add in the Semen Ginkgo extrac, after the mixing, adding 60% (ml/ml) ethanol, to transfer to solids content be 19wt%, as slurry; Master batch is dropped in the fluid bed side spray pot, above-mentioned slurry is slowly sprayed into, constantly be dried to slurry simultaneously and all spray into and make spheroidal particle.
Embodiment 10
1, the preparation of Folium Ginkgo extract: it is an amount of to get the Semen Ginkgo extrac that obtains according to embodiment 3 methods;
2, the preparation of master batch: get lactose and hydroxypropyl starch (1:1) mixture and cross 200 mesh sieves, wherein 60wt% drops in the fluid bed side spray pot, other gets 10wt% lactose and hydroxypropyl starch (1:1) mixture and Semen Ginkgo extrac (after amounting to dry weight, account for the 15wt% of master batch weight) add water and be mixed with slurry and spray into, and sift out granule (particle diameter is 180～250 μ m) as parent nucleus, again parent nucleus is dropped in the pot, continue to spray and state slurry, in the dusting rifle, the lactose of remaining 30wt% and the fine powder of hydroxypropyl starch (1:1) mixture are sprinkled into simultaneously, the particle diameter of parent nucleus is grown up, and the master batch that filters out particle diameter and be 180～250 μ m is standby.
3, the preparation of product: get master batch 850g, the Semen Ginkgo extrac of 500g, with the Semen Ginkgo extrac weight ratio be HPMC and the PVP-K30 mixture of 7:25, wherein the HPMC:PVP-K30 weight ratio is 2:5; Above-mentioned viscosity is adjusted agent HPMC and the PVP-K30 mixture is formulated as the solution that concentration is 15wt% with dehydrated alcohol, add in the Semen Ginkgo extrac, after the mixing, adding 60% (ml/ml) ethanol, to transfer to solids content be 20wt%, as slurry; Master batch is dropped in the fluid bed side spray pot, above-mentioned slurry is slowly sprayed into, constantly be dried to slurry simultaneously and all spray into and make spheroidal particle.
Embodiment 11
1, the preparation of Folium Ginkgo extract: it is an amount of to get the Semen Ginkgo extrac that obtains according to embodiment 4 methods;
2, the preparation of master batch: get dextrin and mannitol (3:1) mixture and cross 200 mesh sieves, wherein 64wt% drops in the fluid bed side spray pot, other gets 16wt% dextrin and mannitol mixture and Semen Ginkgo extrac (after amounting to dry weight, account for the 10wt% of master batch weight) add water and be mixed with slurry and spray into, and sift out granule (particle diameter is 180～250 μ m) as parent nucleus, again parent nucleus is dropped in the pot, continue to spray and state slurry, in the dusting rifle, the dextrin of remaining 20wt% and the fine powder of mannitol mixture are sprinkled into simultaneously, the particle diameter of parent nucleus is grown up, and the master batch that filters out particle diameter and be 450～600 μ m is standby.
3, the preparation of product: get master batch 500g, the Semen Ginkgo extrac of 500g, with the Semen Ginkgo extrac weight ratio be HPMC and the PVP-K30 mixture of 7:25, wherein the HPMC:PVP-K30 weight ratio is 2:5; Above-mentioned viscosity is adjusted agent HPMC and the PVP-K30 mixture is formulated as the solution that concentration is 15wt% with dehydrated alcohol, add in the Semen Ginkgo extrac, after the mixing, adding 60% (ml/ml) ethanol, to transfer to solids content be 20wt%, as slurry; Master batch is dropped in the fluid bed side spray pot, above-mentioned slurry is slowly sprayed into, constantly be dried to slurry simultaneously and all spray into and make spheroidal particle.
Embodiment 12
1, the preparation of Folium Ginkgo extract: it is an amount of to get the Semen Ginkgo extrac that obtains according to embodiment 1 method;
2, the preparation of master batch: get dextrin and mannitol (2:1) mixture and cross 200 mesh sieves, wherein 65wt% drops in the fluid bed side spray pot, other gets 25wt% dextrin and mannitol mixture and Semen Ginkgo extrac (after amounting to dry weight, account for the 10wt% of master batch weight) add water and be mixed with slurry and spray into, and sift out granule (particle diameter is 180～250 μ m) as parent nucleus, again parent nucleus is dropped in the pot, continue to spray and state slurry, in the dusting rifle, the dextrin of remaining 10wt% and the fine powder of mannitol mixture are sprinkled into simultaneously, the particle diameter of parent nucleus is grown up, and the master batch that filters out particle diameter and be 450～600 μ m is standby.
3, the preparation of product: get master batch 450g, the Semen Ginkgo extrac of 800g, with the Semen Ginkgo extrac weight ratio be the polyethylene glycol 6000 of 18:25, with dehydrated alcohol above-mentioned viscosity is adjusted the agent polyethylene glycol 6000 and be formulated as the solution that concentration is 15wt%, add in the Semen Ginkgo extrac, after the mixing, adding 60% (ml/ml) ethanol, to transfer to solids content be 19wt%, as slurry; Master batch is dropped in the fluid bed side spray pot, above-mentioned slurry is slowly sprayed into, constantly be dried to slurry simultaneously and all spray into and make spheroidal particle.
Claims (10)
1. a Chinese medicinal granule that contains Semen Ginkgo extrac is made by Semen Ginkgo extrac and pharmaceutically acceptable carrier, it is characterized in that Semen Ginkgo extrac accounts for 40～90% of percentage by weight, and pharmaceutically acceptable vehicle weight percentage composition is 10～60%.
2. the Chinese medicinal granule that contains Semen Ginkgo extrac according to claim 1, the weight percentage that it is characterized in that Semen Ginkgo extrac is 70～80%, pharmaceutically acceptable vehicle weight percentage composition is 20～30%.
3. as containing the Chinese medicinal granule of Semen Ginkgo extrac as described in the claim 2, the weight percentage that it is characterized in that Semen Ginkgo extrac is 70～80%, and pharmaceutically acceptable vehicle weight percentage composition is 20～30%.
4. the Chinese medicinal granule that contains Semen Ginkgo extrac according to claim 1 is characterized in that described pharmaceutically acceptable carrier comprises that in sucrose, dextrin, starch, lactose, mannitol, xylitol, chitosan, SHUANGQITANG, soluble starch, Pulvis Talci, water solublity dextrin sodium carboxymethyl cellulose (CMS-Na), microcrystalline Cellulose (MCC), micropowder silica gel, hydroxypropyl starch, ethanol, hydroxypropyl cellulose, Polyethylene Glycol, chitosan, the polyvidone one or more unite use.
5. as containing the Chinese medicinal granule of Semen Ginkgo extrac as described in the claim 4, it is characterized in that described pharmaceutically acceptable carrier is preferably: microcrystalline Cellulose (MCC), micropowder silica gel, Polyethylene Glycol, Pulvis Talci, chitosan, Pulvis Talci, polyvidone.
6. the Chinese medicinal granule that contains Semen Ginkgo extrac according to claim 1, it is characterized in that described granule comprises master batch and the shell that is positioned on the master batch, profile is sphere or class sphere, bulk density is 0.6～1.3g/m, dissolve scattered time limit is 0.4～5 minute, and active constituents of medicine is included among master batch and/or the shell.
7. the Chinese medicinal granule that contains Semen Ginkgo extrac according to claim 1 is characterized in that its particle diameter is 700～1500 μ m.
8. the Chinese medicinal granule that contains Semen Ginkgo extrac according to claim 1 is characterized in that described granule also contains coating, and the weight of coating materials accounts for 2～5wt% of granule gross weight.
9, each described preparation method that contains the Chinese medicinal granule of Semen Ginkgo extrac of claim 1～7 is characterized in that step is as follows:
(1) preparation of Folium Ginkgo extract: get the 1000g Folium Ginkgo and pulverize, measure acetone with 5 times: water (70:30) mixed liquor heating extraction 2 times, each 2 hours, temperature was 50～60 ℃, and merge extractive liquid, filters, and concentrating under reduced pressure becomes Folium Ginkgo extract;
(2) preparation of master batch: i. gets an amount of pharmaceutically acceptable carrier, the perhaps mixture of itself and Semen Ginkgo extrac dry powder, and crushing screening obtains the satisfactory material of granularity; Ii. get the material of a part of step I, drop in spray of fluid bed side or the end spray pot, other gets it filled and learns acceptable carrier and/or Semen Ginkgo extrac and add water and be mixed with slurry, adopt spray of fluid bed side or end pressure spray process to spray into, and sift out granule, again parent nucleus is dropped in the pot as parent nucleus, continue to spray and state slurry, the material of remaining step I is sprinkled into fine powder in the dusting rifle simultaneously, the particle diameter of parent nucleus is grown up, filter out the satisfactory master batch of particle diameter;
(3) preparation of product: it is an amount of to get master batch, and acceptable carrier is an amount of, and Semen Ginkgo extrac is an amount of; Above-mentioned acceptable carrier is added in the above-mentioned Semen Ginkgo extrac, and it is standby as slurry to mix into suspension; Above-mentioned master batch is dropped in the fluid bed side spray pot, and above-mentioned slurry slowly sprays into, and all sprays into to slurry, makes spheroidal particle.
10, as containing the preparation method of the Chinese medicinal granule of Semen Ginkgo extrac as described in as described in the claim 9, it is characterized in that step is as follows:
(1) it is an amount of to get Semen Ginkgo extrac;
(2) preparation of master batch: the mixture of getting dextrin and starch weight ratio and be 1:1 is crossed 200 mesh sieves, and wherein 60-65wt% drops in the fluid bed side spray pot as bed material; 10-15wt% dextrin and starch mixture, amount to the Semen Ginkgo extrac that accounts for the 15wt% of master batch weight after the dry weight, adding water is mixed with slurry and sprays into, and to sift out particle diameter be that 180～250 μ m granules are as parent nucleus, again parent nucleus is dropped in the pot, continue to spray and state slurry, in the dusting rifle dextrin of surplus and the fine powder of starch mixture are sprinkled into simultaneously, the particle diameter of parent nucleus is grown up, the master batch that filters out particle diameter and be 450～600 μ m is standby;
(3) preparation of product: get master batch 450g, the Semen Ginkgo extrac of 300g, with the Semen Ginkgo extrac weight ratio be 18: 25 polyethylene glycol 6000, be HPMC and the PVP-K30 mixture of 7:25 perhaps with the Semen Ginkgo extrac weight ratio, wherein the HPMC:PVP-K30 weight ratio is 2:5; With dehydrated alcohol above-mentioned viscosity is adjusted and a kind ofly in agent polyethylene glycol 6000 or HPMC and the PVP-K30 mixture to be formulated as the solution that concentration is 15wt%, add in the Semen Ginkgo extrac, after the mixing, adding 60% (ml/ml) ethanol, to transfer to solids content be 19wt%, as slurry; Master batch is dropped in the fluid bed side spray pot, above-mentioned slurry is slowly sprayed into, constantly be dried to slurry simultaneously and all spray into and make spheroidal particle.
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| CN2007101503027A CN101439057B (en) | 2007-11-22 | 2007-11-22 | Chinese medicine granule containing gingko extract and preparation method thereof |
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| CN2007101503027A CN101439057B (en) | 2007-11-22 | 2007-11-22 | Chinese medicine granule containing gingko extract and preparation method thereof |
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| CN101439057A true CN101439057A (en) | 2009-05-27 |
| CN101439057B CN101439057B (en) | 2012-07-18 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103768245A (en) * | 2012-10-26 | 2014-05-07 | 苏州市洋海电子有限公司 | Chinese herbal preparation |
| CN103800392A (en) * | 2012-11-07 | 2014-05-21 | 苏州市洋海电子有限公司 | Compound Poria cocos preparation |
| CN105901649A (en) * | 2016-05-03 | 2016-08-31 | 王胜 | Plant salt containing ginkgo extracts and preparation method thereof |
| CN110192588A (en) * | 2019-06-13 | 2019-09-03 | 四川顺翔银杏生物科技开发有限公司 | A kind of ginkgo leaf granular tea and preparation method thereof |
| CN112999192A (en) * | 2021-03-04 | 2021-06-22 | 中国中医科学院望京医院(中国中医科学院骨伤科研究所) | Quick-release solid preparation and preparation method thereof |
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| CN1273116C (en) * | 2004-06-22 | 2006-09-06 | 张晴龙 | Orally disintegrating tablet of gingko leaf and its preparation process |
| CN1650972A (en) * | 2004-11-26 | 2005-08-10 | 复旦大学 | Glow release micro pill containing gingko leaf extract and its preparation method |
| CN1872098A (en) * | 2005-06-01 | 2006-12-06 | 天津天士力制药股份有限公司 | Application of preparation of gingkgo extractive in resistant medication anti aspirin |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103768245A (en) * | 2012-10-26 | 2014-05-07 | 苏州市洋海电子有限公司 | Chinese herbal preparation |
| CN103800392A (en) * | 2012-11-07 | 2014-05-21 | 苏州市洋海电子有限公司 | Compound Poria cocos preparation |
| CN105901649A (en) * | 2016-05-03 | 2016-08-31 | 王胜 | Plant salt containing ginkgo extracts and preparation method thereof |
| CN110192588A (en) * | 2019-06-13 | 2019-09-03 | 四川顺翔银杏生物科技开发有限公司 | A kind of ginkgo leaf granular tea and preparation method thereof |
| CN112999192A (en) * | 2021-03-04 | 2021-06-22 | 中国中医科学院望京医院(中国中医科学院骨伤科研究所) | Quick-release solid preparation and preparation method thereof |
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|---|---|
| CN101439057B (en) | 2012-07-18 |
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