CN101431979A - A mild leave-on composition - Google Patents

Abstract

The present invention relates to a leave on companion animal composition having a composition having a Total Lather Volume of from about 300ml to about 700ml, ILlalpha of from about 0 pg/ml to about 7000 pg/ml, and Friction Coefficient of from about 1.2 to about 2.0. The composition may contain polyoxyethylene 20 isohexadecyl ether.

Description

Gentle leave compositions

Invention field

The present invention relates to a kind of leave companion animals compositions, it is that about 0pg/mL is about 1.2 to about 2.0 compositions to about 7000pg/mL and coefficient of friction for about 300mL to about 700mL, IL-1 α that described compositions comprises total foam volume.

Background of invention

In order to keep the health of companion animals, the combing companion animals is necessary.Usually, the product that is used to clean, nurse one's health or handle companion animals must satisfy certain standard.These standards comprise cleaning effectiveness, dermal sensation, to skin, hair and oculomucous mildness, please people's taste and foam volume.The cleaning agent of ideal companion animal is cleaning skin or hair leniently, only causes very little stimulation or can not cause any stimulation, and can not make skin or hair too dry after using.

In cleaning, processing and conditioning process, companion animals is tending towards wriggling and attempts to escape, and this causes cleaning/and the poor efficiency of conditioning products uses and/or contacts with the poor efficiency of companion animals.In addition, for companion animals, the shower process is normally very offending, and causes companion animals anxiety aggravation, nervous, and brings sour experience therefore for the owner of companion animals.

Most of companion animals Cleasing compositions need the water source to remove Cleasing compositions.If compositions is not removed fully, then companion animals can demonstrate irritated and pruritus symptom, and this can cause eczema occurring on the companion animals skin.In addition, in some travelling situation, in limited time under the condition and/or, search suitable water source and be inconvenient or impossible only in view of the size of companion animals.

Therefore, still need a kind of like this compositions, described compositions is easy to use, being suitable for consumer uses, can clean effectively, handle and nurse one's health,, and provide the taste and the ideal foam volume of pleasing the people skin, hair and the eye mucosa gentleness of companion animals.In addition, also need a kind of like this compositions, described compositions can be applied to companion animals and need not water removes, so that consumer can concentrate on task at hand, promptly wash, clean, handle and nurse one's health, and the contact of the consoling property between user and the companion animals is provided simultaneously, and needn't considers with the water source described compositions flush away on one's body the companion animals.

Summary of the invention

The present invention relates to a kind of like this leave companion animals compositions, described compositions comprises total foam volume and is the compositions of about 300mL to about 700mL.

The invention still further relates to a kind of like this leave companion animals compositions, described compositions comprises IL-1 α and is the compositions of about 0pg/mL to about 7000pg/mL.

The invention still further relates to a kind of like this leave companion animals compositions, described compositions comprises total foam volume and is the compositions of about 300mL to about 700mL; Described compositions has the IL-1 α of about 0pg/mL to about 7000pg/mL; And described compositions has about 1.2 to about 2.0 coefficient of friction.

The invention still further relates to a kind of like this article of commerce, described article of commerce comprises container, and described container comprises leave companion animals compositions.Described compositions can provide conditioning, cleaning and handles beneficial effect and comprise when being applied to companion animals: (a) total foam volume is about 300mL compositions of about 700mL extremely; (b) IL-1 α is the described compositions of about 0pg/mL to about 7000pg/mL; Wherein said vessel is useful on conditioning, cleaning and handles the operation instruction of companion animals, and described operation instruction comprises the routine washing, gives described companion animals massage and the optional explanation that pats dry with towel.

The invention still further relates to and use leave compositions as herein described to clean, nurse one's health and handle companion animals skin or hair and the similar method that contains keratin surface (mainly being skin and hair).

The invention still further relates to the cover box that is used for companion animals, described cover box comprises: (a) compositions; (b) container.

Detailed Description Of The Invention

Leave compositions of the present invention and the inventive method are fit to be used for cleaning, be handled and the conditioning companion animals by user.Because using method is convenient and simple, user can utilize the present invention to clean, handle or nurse one's health their companion animals.

As used herein, term " companion animals " is meant the animal that comprises (for example) Canis familiaris L., cat, horse, rabbit, Cavia porcellus, hamster, gerbil jird, ferret, zoo mammal etc.Canis familiaris L., rabbit, horse and cat are especially preferred.

As used herein, " leave " is meant that the requirement according to user can or be retained in companion animals compositions on one's body from flush away on one's body the companion animals after using.Preferably, described compositions is a leave.

Term used herein " fluid " is meant " fluid " that is selected from by the following group of forming: water, monobasic and polyhydric alcohol (glycerol, propylene glycol, ethanol, isopropyl alcohol etc.), hydrocarbon ils such as mineral oil, organosilicon liquid, also has triglyceride oil, also have fluid resin such as silicone MQ resin, the ester of hydrocarbon and ether, alcohol, spice, fragrance oil, natural oil such as terpenes, various trees and vegetable oil, and above-mentioned mixture, and can comprise dissolving or be dispersed in wherein or join wherein other component.

As used herein, phrase " is substantially free of " and is meant that described compositions comprises less than about 3% by the weight of described compositions, preferably less than about 1%, be more preferably less than about 0.5%, even be more preferably less than about 0.25%, also be more preferably less than approximately 0.1%, even also be more preferably less than 0.01% described composition.

Form

The present invention relates to the leave compositions used by the individual, described compositions be preferably used for cleaning, nursing one's health and/or handle companion animals skin, hair, refer to/toenail, ear, palm or other similarly contain the keratin surface.Described leave compositions can be used for the All Ranges of companion animals.Leave compositions of the present invention can be liquid or semiliquid, cream or mouse compositions.For limiting the compositions and methods of the invention, contemplated product form is generally the leave compositions, this is meant compositions is locally applied on the companion animals that (being in a few minutes) keeps thereon and/or the water flush away subsequently, and/or uses substrate or other suitable mode that removes to wipe.In addition, described compositions can with utensil for example mitten, (thumb separates) mitten and/or glove combine, be locally applied to companion animals then.

Preferably, described leave compositions is gentle, and this is meant that these compositionss provide enough cleaning or decontamination beneficial effects, but can not make companion animals over-drying, and still meets the foaming standard, so that described reagent can not produce a large amount of foams.

According to foam volume measurements determination hereinafter described, leave compositions of the present invention has about 300mL to about 700mL, and about 310mL is to about 600mL, and about 315mL is about 500mL extremely, and about 320mL is about 400mL and about 325mL total foam volume of about 380mL extremely extremely.

According to foam volume measurements determination hereinafter described, leave compositions of the present invention has about 100mL to about 230mL, and about 105mL is to about 200mL, and about 110mL is about 180mL extremely, and about 120mL is about 170mL and the about 125mL instantaneous foam volume of about 160mL extremely extremely.

Skin activity and inflammatory cytokine discharge be accepted for everybody with for example irritated relevant the measuring of unfavorable skin effect.According to allergy evaluation measurements determination hereinafter described, leave compositions of the present invention has about 0 pg/ml (pg/mL) to about 7000pg/mL, about 70pg/mL is to about 6000pg/mL, about 90pg/mL is to about 5000pg/mL, about 100pg/mL is to about 4000pg/mL, and about 110pg/mL is to the IL1 α of about 3000pg/mL.

According to allergy evaluation measurements determination hereinafter described, leave compositions of the present invention has about 20% to about 100%, about 25% to about 90%, about 30% to about 85%, about 35% to about 80% and about 40% to about 75% activity.

According to allergy evaluation measurements determination hereinafter described, leave compositions of the present invention has about 0 to about 8 pg/ml (pg/mL) to about 800pg/mL, about 50pg/mL is to about 700pg/mL, about 90pg/mL is to about 600pg/mL, about 100pg/mL is to about 500pg/mL, about 150pg/mL is to about 400pg/mL and the about 200pg/mL IL8 of about 300pg/mL extremely.

After leave compositions-treated of the present invention, hair preferably shows about 1.2 to about 2, about 1.3 to about 1.9, about 1.4 to about coefficient of friction of 1.8, about 1.5 to about 1.8.According to friction testing hereinafter described, measure coefficient of friction.

Surface active agent composition

Compositions of the present invention can comprise surface active agent composition.Described surface active agent composition comprises and is suitable for surfactant that companion animals is used that described surfactant is selected from the group of being made up of following: anion surfactant, non-ionic surface active agent, zwitterionic surfactant, cationic surfactant, soap and their mixture.

When existing, the surface active agent composition concentration that described leave compositions comprises by the weight of described compositions at about .1% to about 95%, about .5% extremely about 95%, about 1% to about 90%, about 5% to about 80%, about 10% to about 70% and about 15% to about 60% scope.The surfactant concentration that described surface active agent composition comprises by the weight of described surface active agent composition at about .1% to about 50%, about 1% to about 35%, about 5% to about 30%, about 8% to about 25% and about 10% to about 24% scope.The preferred pH scope of described leave compositions is about 4 to about 9, more preferably from about 7.

Anion surfactant

The anionic surfactant concentration that described leave compositions can comprise by the weight of described surface active agent composition at about .1% to about 50%, about .4% is to about 30%, about .5% is extremely about 25%, about 1% to about 20%, about 2% to about 10% scope.

The limiting examples that can be used for the anion surfactant in the present composition is disclosed in " Detergentsand Emulsifiers " the North America version (1986) of the McCutcheon that is published by allured Publishing Corporation; " FunctionalMaterials " North America version (1992) of McCutcheon; And in the United States Patent (USP) 3,929,678 of authorizing people such as Laughlin announced in 30th of December in 1975.

There is multiple anion surfactant to can be used for herein.The limiting examples of anion surfactant comprises and being selected from by those of the following group of forming: alkyl and alkyl ether sulfate; sulphated monoglycerides; sulfonation alkene; alkylaryl sulfonates; uncle or secondary paraffin sulfonate; alkyl sulfosuccinate; acyl taurine salt; acyl-hydroxyethyl sulfonate; alkyl glycerol ether sulfonate; sulfonated formate; alpha-sulfonated fatty acid; alkylphosphonic; acyl glutamate; acyl sarcosinates; alkyl acetate sulfonate; acylated peptide; the alkyl ether carboxy acid salt; acyl-lactate; anionic fluorosurfactants; and their combination.

The limiting examples of anion surfactant comprises and being selected from by those of the following group of forming: sarcosinate, sulfate, ethoxylated sulfate, sulfonate, glyceryl sulfonate, isethionate, phosphate, taurate, lactate, glutamate, Glu, soap, sulfosuccinate, ethoxylation sulfosuccinate and their mixture.

Other anionic species that can be used for this paper comprises fatty acid soaps (being alkali metal salt, as sodium or potassium salt), and fatty acid soaps has usually and has about 8 to about 24 carbon atoms, preferred about 10 fatty acids to about 20 carbon atoms.These fatty acids that are used to prepare soap can derive from natural origin, for example derived from the glyceride (as Petiolus Trachycarpi oil, Oleum Cocois, soybean oil, Oleum Ricini, Adeps Bovis seu Bubali, Adeps Sus domestica etc.) of plant or animal.In addition, anionic species comprises that the example of described plant and/or tallow and oil comprises sodium laurate, Sodium myristate, palmitate, stearate, Adeps Bovis seu Bubali hydrochlorate, cocos nucifera oil hydrochlorate derived from the natural soap of the saponification of plant and/or tallow and oil.Described fatty acid also can synthesize and makes.The preparation of soap and they is described in detail in United States Patent (USP) 4,557, in 853.

The anion surfactant that is used for described compositions comprises alkyl and alkyl ether sulfate.These materials have chemical formula R10-SO3M and R1 (CH2H4O) x-O-SO3M separately, wherein R1 be saturated or undersaturated, have side chain or a unbranched alkyl, have about 8 to about 24 carbon atoms, x is 1 to 10, and M is a water-soluble cationic, for example ammonium, sodium, potassium, magnesium, triethanolamine, diethanolamine and monoethanolamine.Usually by using sulfur trioxide or other known sulfation technology, make described alkyl sulfate via the sulfation of monohydric alcohol (having about 8) to about 24 carbon atoms.Usually the mode with the condensation product of oxirane and monohydric alcohol (having about 8 to about 24 carbon atoms) makes alkyl ether sulfate, then sulphation.These alcohol can be derived from fat, and for example Oleum Cocois or Adeps Bovis seu Bubali maybe can be synthesized.The instantiation that can be used for the alkyl sulfate in the described compositions is the vitriolic sodium salt of lauryl or myristyl, ammonium salt, potassium salt, magnesium salt or TEA salt.The example of available alkyl ether sulfate comprises the vitriolic ammonium salt of laureth-3, sodium salt, magnesium salt or TEA salt.

Another kind of suitable anion surfactant is that formula is the sulphated monoglycerides of R1CO-O-CH2-C (OH) H-CH2-O-SO3M, wherein R1 be saturated or undersaturated, have side chain or a unbranched alkyl, have about 8 to about 24 carbon atoms, and M is a water-soluble cationic, for example ammonium, sodium, potassium, magnesium, triethanolamine, diethanolamine and monoethanolamine.These make by the follow-up sulfation of glycerol and fatty acid (having about 8 to about 24 carbon atoms) reaction generation monoglyceride and this monoglyceride and sulfur trioxide usually.The example of sulphated monoglycerides is a cocoyl monoglyceride sodium sulfate.

Other suitable anion surfactant comprises that formula is the alkene sulfonate of R1SO3M, wherein R1 has about 12 monoolefines to about 24 carbon atoms, and M is a water-soluble cationic, for example ammonium, sodium, potassium, magnesium, triethanolamine, diethanolamine and monoethanolamine.Be prepared as follows these chemical compounds: use the sulfur trioxide that does not cooperate to come the sulfonation alpha-olefin, then under certain condition in and acidic reaction mixture so that all sultoness that generate in the reaction all are hydrolyzed to obtain corresponding hydroxyl paraffin sulfonate.The example of sulfonation alkene is a C14/C16 alpha-olefin sodium sulfonate.

Other suitable anion surfactant is that formula is the linear alkylbenzene sulfonate (LAS) of R1-C6H4-SO3M, wherein R1 be saturated or undersaturated, have side chain or a unbranched alkyl, have about 8 to about 24 carbon atoms, and M is a water-soluble cationic, for example ammonium, sodium, potassium, magnesium, triethanolamine, diethanolamine and monoethanolamine.These can generate by the sulfonating reaction of linear alkylbenzene (LAB) and sulfur trioxide.The example of this anion surfactant is a dodecyl base benzene sulfonic acid sodium salt.

Other anion surfactants that are applicable to this compositions comprise that also formula is uncle or the secondary paraffin sulfonate of R1SO3M, wherein R1 be saturated or undersaturated, have side chain or a unbranched alkyl chain, have about 8 to about 24 carbon atoms, and M is a water-soluble cationic, for example ammonium, sodium, potassium, magnesium, triethanolamine, diethanolamine and monoethanolamine.These pass through to use sulfur dioxide sulfonation paraffin usually in the presence of chlorine and ultraviolet light, or make by the known method of sulfonating of another kind.Described sulfonating reaction can occur in the secondary position or the uncle position of alkyl chain.The example that can be used for the paraffin sulfonate of this paper is the alkali metal salts or ammonium salt of C13-C17 alkanesulfonic acid.

Other suitable anion surfactant is an alkyl sulfosuccinate, and described alkyl sulfosuccinate comprises the N-disodium octadecyl sulfosuccinate; Lauryl 2-Sulfosuccinic acid diammonium; N-(1,2-dicarboxyl ethyl)-N-octadecyl 2-Sulfosuccinic acid four sodium; The diamyl ester of sodium sulfosuccinate; The dihexyl ester of sodium sulfosuccinate; Dioctyl ester with sodium sulfosuccinate.

The also spendable taurate that is based on taurine, described taurine also is called as 2-aminoethyl sulfonic acid.The example of taurate comprises the N-alkyl taurine, for example according to United States Patent (USP) 2,658, describe in detail in 072, by lauryl amine and sodium isethionate reaction make those, described document is incorporated herein with way of reference in full.Other example based on taurine comprises the acyl group taurine that generates by N methyl taurine and fatty acid (having about 8 to about 24 carbon atoms) reaction.

Another kind ofly be applicable to that the anion surfactant in the described compositions is an acyl-hydroxyethyl sulfonate.Described acyl-hydroxyethyl sulfonate has formula R1CO-O-CH2CH2SO3M structure usually, wherein R1 be saturated or undersaturated, have side chain or unbranched alkyl, have about 10 to about 30 carbon atoms, and M is a cation.These normally generate by the reaction of fatty acid (having about 8 to about 30 carbon atoms) with the hydroxyethylsulfonic acid. alkali metal salt.The limiting examples of these acyl-hydroxyethyl sulfonates comprises Ammonium cocoyl isethionate, cocoyl sodium isethionate, lauroyl sodium isethionate and their mixture.

Other suitable anion surfactant is that formula is the alkyl glycerol ether sulfonate of R1-OCH2-C (OH) H-CH2-SO3M, wherein R1 be saturated or undersaturated, have side chain or a unbranched alkyl, have about 8 to about 24 carbon atoms, and M is a water-soluble cationic, for example ammonium, sodium, potassium, magnesium, triethanolamine, diethanolamine and monoethanolamine.These can generate by reaction or other known method of epoxychloropropane and sodium sulfite and aliphatic alcohol (having about 8 to about 24 carbon atoms).An example is a cocoyl glyceryl ether sulfonic acid sodium.

Other suitable anion surfactant comprises that formula is that alpha-sulfonated fatty acid and the formula of R1-CH (SO4)-COOH is the sulfonation methyl ester of R1-CH (SO4)-CO-O-CH3, wherein R1 be saturated or undersaturated, have side chain or unbranched alkyl, have about 8 to about 24 carbon atoms.These can generate by the sulfonating reaction of fatty acid or alkyl methacrylate ester (having about 8 to about 24 carbon atoms) and sulfur trioxide, or generate by the known sulfonation technology of another kind.Example comprises α-sulfonated fatty acid distribution of coconut oil and lauryl methyl ester.

Other anionic species comprises phosphate, for example by five phosphorous oxide with have side chain or unbranched and have about 8 monoalkyl, dialkyl group and trialkyl phosphate that generate to the reaction of the monohydric alcohols of about 24 carbon atoms.These also can be made by other known phosphate method.The example of this type of surfactant is a lauryl sodium phosphate or dilauryl sodium phosphate.

Other anionic species comprises the acyl glutamate that meets formula R1CO-N (COOH)-CH2CH2-CO2M structure; wherein R1 be saturated or undersaturated, have side chain or unbranched alkyl or an alkenyl; have about 8 to about 24 carbon atoms, and M is a water-soluble cationic.The limiting examples of described acyl glutamate comprises sodium lauroyl glutamate and cocoyl sodium glutamate.

Other anionic species comprises the alkane acylsarcosine salt that meets formula R1CON (CH3)-CH2CH2-CO2M structure, wherein R1 be saturated or undersaturated, have side chain or unbranched alkyl or an alkenyl, have about 10 to about 20 carbon atoms, and M is a water-soluble cationic.The limiting examples of described alkane acylsarcosine salt comprises sodium lauroyl sarcosine, cocoyl sodium sarcosinate and Hamposyl L ammonium.

Other anionic species comprises the alkyl ether carboxy acid salt who meets formula R1-(OCH2CH2) x-OCH2-CO2M structure, wherein R1 be saturated or undersaturated, have side chain or unbranched alkyl or an alkenyl, have about 8 to about 24 carbon atoms, x is 1 to 10, and M is a water-soluble cationic.Described alkyl ether carboxy acid salt's limiting examples comprises the laureth carboxylic acid sodium.

Other anionic species comprise meet formula R1CO-[O-CH (CH3)-CO] acyl-lactate of x-CO2M structure; wherein R1 be saturated or undersaturated, have side chain or unbranched alkyl or an alkenyl; have about 8 to about 24 carbon atoms, x is 3, and M is a water-soluble cationic.The limiting examples of described acyl-lactate comprises the cocoyl sodium lactate.

Other anionic species comprises carboxylate, and its limiting examples comprises lauroyl carboxylic acid sodium, cocoyl carboxylic acid sodium and lauroyl carboxylic acid ammonium.Also can use anionic fluorosurfactants.

Other anionic species comprises phosphate, for example monoalkyl, dialkyl group and trialkyl phosphate.The limiting examples that preferably can be used for the anion surfactant of this paper comprises and being selected from by those of the following group of forming: sodium lauryl sulfate; ammonium lauryl sulfate; lauryl polyethenoxy ether sodium sulfate; sodium laureth sulfate; the tridecyl polyethenoxy ether sodium sulfate; cetyl ammonium sulfate; cetyl sodium sulfate; Ammonium cocoyl isethionate; the lauroyl sodium isethionate; 2-Lauroyloxypropionic acid sodium; the 2-Lauroyloxypropionic acid triethanolamine; Caproyllactic acid sodium; sodium lauroyl sarcosine; Hamposyl M sodium; the cocoyl sodium sarcosinate; sodium lauroylmethyl taurate; cocoyl N-methyltaurine sodium; sodium lauroyl glutamate; nutmeg acyl sodium glutamate and cocoyl sodium glutamate; and their mixture.

Non-ionic surface active agent

The non-ionic surface active agent concentration that described leave compositions can comprise by the weight of described surface active agent composition about 0.1% to about 50%, about 0.25% to about 30%, about 0.5% to about 25%, about 1.0% to about 20% and about 1.5% to about 10% scope.

The limiting examples that can be used for the non-ionic surface active agent in the present composition is disclosed in " Detergentsand Emulsifiers " the North America version (1986) of the McCutcheon that is published by allured Publishing Corporation; In " FunctionalMaterials " North America version (1992) of McCutcheon.

The ionic surfactant pack that can be used for this paper is drawn together and is selected from by those of the following group of forming: alkyl androstanediol, poly glucoside, polyhydroxy fatty acid amide, alkoxy fatty acid ester, sugar ester, ethoxylation ester, glyceride, ethoxylate, propoxylate, PEG/PPG copolymer, glyceride, sorbitan and their mixture.More particularly, Polyethylene Glycol 20 sorbitans, one lauric acid esters (polysorbate 20), Polyethylene Glycol 5 soyasterols, stearyl polyoxyethylene ether-20, cetearyl polyoxyethylene ether-20, PPG-2 methyl glucose ether distearate, ceteth-10, polysorbate 80, polysorbate 60, the glyceryl stearate, the PEG-100 stearate, polyoxyethylene 20 sorbitan trioleate (polysorbate 85), sorbitan one lauric acid ester, polyoxyethylene 4 lauryl ether sodium stearates, polyglyceryl-4 isostearate, and their mixture.

Alkyl androstanediol and alkyl polyglucoside can be used for herein, and can be defined as long-chain alcohol such as C8-30 alcohol and sugar or starch or sugar or starch polymer widely be the condensation product of glycoside or poly glucoside.These chemical compounds can be by formula (S) _n-O-R represents that wherein S is a sugar moieties, for example glucose, fructose, mannose and galactose; N is about 1 to about 1000 integer, and R is the C8-30 alkyl.The example that can derive the long-chain alcohol of alkyl comprises decanol, spermol, stearyl alcohol, lauryl alcohol, tetradecanol, oleyl alcohol etc.The preferred embodiment of these surfactants comprises that S wherein is that glucose moiety, R are that C8-20 alkyl and n are those of about 1 to about 9 integer.The commercial examples of these surfactants comprises decyl poly glucoside (deriving from Henkel with trade name APG 325 CS) and lauryl poly glucoside (deriving from Henkel with trade name APG 600CS and 625 CS).Also spendable is the sucrose ester surfactant, for example sucrose cocos nucifera oil acid esters and Surfhope SE Cosme C 1216.

Other spendable ionic surfactant pack is drawn together polyhydroxy fatty acid amide surfactant, its more specifically example comprise the glucamide that meets following structural formula:

Wherein: R ¹Be H, C ₁-C ₄Alkyl, 2-hydroxyethyl, 2-hydroxyl-propyl group, preferred C ₁-C ₄Alkyl, more preferably methyl or ethyl, most preferable; R ²Be C ₅-C ₃₁Alkyl or alkenyl, preferred C ₇-C ₁₉Alkyl or alkenyl, more preferably C ₉-C ₁₇Alkyl or alkenyl, most preferably C ₁₁-C ₁₅Alkyl or alkenyl; And Z is the polyhydroxy alkyl part with straight-chain alkyl chain, or its alkoxy derivative (preferred ethoxylation or propenoxylated), and described hydrocarbyl chain has at least 3 hydroxyls that directly link to each other with chain.Z is preferably sugar moieties, and this sugar moieties is selected from the group of being made up of following: glucose, fructose, maltose, lactose, galactose, mannose, xylose and their mixture.The especially preferred surfactant that meets said structure is cocos nucifera oil alkyl N-methyl glucosamine amide (i.e. R wherein ²The CO-part is derived from fatty acid distribution of coconut oil).The preparation method of composition that comprises polyhydroxy fatty acid amide for example is disclosed in February 18 nineteen fifty-nine by Thomas Hedley; Co., Great Britain's patent specification 809,060 of Ltd. announcement; The United States Patent (USP) of authorizing E.R.Wilson 2,965,576 of nineteen sixty December announcement on the 20th; The United States Patent (USP) of authorizing A.M.Schwartz 2,703,798 that announce March 8 nineteen fifty-five; In the United States Patent (USP) of announcing in 25th with December in 1934 of authorizing Piggott 1,985,424; Every piece of document all is incorporated herein with way of reference in full.

Other example of non-ionic surface active agent comprises amine oxide.Amine oxide general molecular formula R ₁R ₂R ₃N → O structure, wherein R ₁Comprise have about 8 to about 18 carbon atoms, 0 to about 10 ethylene oxide moieties and 0 alkyl, alkenyl or monohydroxy alkyl to about 1 glyceryl part, and R ₂And R ₃Comprise about 1 to about 3 carbon atoms and 0 to about 1 hydroxyl, as methyl, ethyl, propyl group, ethoxy or hydroxypropyl.Arrow in the formula is that the routine of semi-polar bond is represented.The example that is applicable to the amine oxide among the present invention comprises dimethyl-dodecyl amine oxide, oil base two (2-ethoxy) amine oxide, dimethyloctylamine oxide, dimethyl-decyl amine oxide, dimethyl-myristyl amine oxide, 3,6,9-trioxa heptadecyl diethyl amine oxide, two (2-ethoxy)-myristyl amine oxides, 2-dodecyloxy ethyl dimethyl oxidation amine, 3-dodecyloxy-2-hydroxypropyl (3-hydroxypropyl) amine oxide, dimethyl cetyl amine oxide.

The limiting examples that can be used for the non-ionic surface active agent of this paper is selected from by the following group that those are formed: C8-C14 glucose amide, C8-C14 alkyl polyglucoside, sucrose cocos nucifera oil acid esters, Surfhope SE Cosme C 1216, lauryl amine oxide, cocoyl amine oxide and their mixture.

Amphoteric surfactant

The concentration of the amphoteric surfactant that described leave compositions comprises by the weight of described surface active agent composition at about .1% to about 50%, about .4% is to about 30%, about .5% is extremely about 25%, about 1% to about 20%, about 2% to about 10% scope.

As used herein, term " amphoteric surfactant " also is intended to comprise zwitterionic surfactant, and it is the subclass of the known amphoteric surfactant of the skilled formulator in this area.

There is multiple amphoteric surfactant to can be used in the compositions of the present invention.Especially available those of aliphatic secondary amine and tertiary amines derived thing of extensively being described as, preferably wherein said nitrogen is cation state, wherein aliphatic group can be straight chain or have side chain, and one of them group comprises ionogenic water solubilization radical, as carboxyl, sulfonate radical, sulfate radical, phosphate radical or phosphonate ester.

The limiting examples that can be used for the amphoteric surfactant in the present composition is disclosed in " Detergentsand Emulsifiers " the North America version (1986) of the McCutcheon that is published by allured Publishing Corporation; In " FunctionalMaterials " North America version (1992) of McCutcheon; These two pieces of documents all are incorporated herein with way of reference in full.

The limiting examples of both sexes or zwitterionic surfactant is selected from by the following group that those are formed: amine oxide, betanin, sulfobetaines, hydroxyl sulfo betaine, alkyl imino acetate, iminodiacetic alkanoate, amino-alkane hydrochlorate and their mixture.

The example of betanin comprises the senior alkyl betanin, for example cocoyl dimethyl carboxymethyl betaine, the lauryl dimethyl carboxymethyl betaine, lauryl dimethyl α-carboxyethyl betanin, cetyl dimethyl carboxymethyl betaine, cetyl dimethyl betaine (deriving from Lonza Corp.) with trade name Lonzaine 16SP, lauryl two-(2-ethoxy) carboxymethyl betaine, oil base dimethyl γ-carboxylic CAB, lauryl two-(2-hydroxypropyl) α-carboxyethyl betanin, the cocoyl dimethyl sulfopropyl betaine, lauryl dimethyl sulfoethyl betanin, lauryl two-(2-ethoxy) sulfopropyl betaine, amido betaine and amino sulfobetaines (RCONH (CH wherein ₂) ₃Group is connected on the nitrogen-atoms of betanin), oil-based betaine (deriving from Henkel) and cocamido propyl betaine (deriving from Henkel) with trade name Velvetex BK-35 and BA-35 with trade name both sexes Velvetex OLB-50.

The example of sulfobetaines and hydroxyl sulfo betaine comprises for example material of cocos nucifera oil acylamino-propyl hydroxy sulfobetaines (deriving from Rhone-Poulenc with trade name Mirataine CBS).

What preferably can be used for this paper is the amphoteric surfactant with following structure:

R wherein ¹For unsubstituted, saturated or undersaturated, have about 9 straight or branched alkyl to about 22 carbon atoms.Preferred R ¹Have about 11 to about 18 carbon atoms; More preferably from about 12 to about 18 carbon atoms; Also more preferably from about 14 to about 18 carbon atoms; M is 1 to about 3, and more preferably from about 2 to about 3, and more preferably about 3 integer; N is 0 or 1, preferred 1; R ²And R ³Be independently selected from the group of forming by following: have 1 to the unsubstituted of about 3 carbon atoms or by the mono-substituted alkyl of hydroxyl.Preferably, R ²And R ³Be CH ₃X is selected from the group of being made up of following: CO ₂, SO ₃And SO ₄R ⁴Be selected from the group of forming by following: saturated or undersaturated, do not replace or mono-substituted by hydroxyl, have 1 a straight or branched alkyl to about 5 carbon atoms.When X is CO ₂The time, R ⁴Preferably has 1 or 3 carbon atom, more preferably 1 carbon atom.When X is SO ₃Or SO ₄The time, R ⁴Preferably have about 2 to about 4 carbon atoms, more preferably 3 carbon atoms.

Examples of amphoteric surfactants of the present invention comprises following chemical compound:

(this material also has the CTFA name to the cetyl dimethyl betaine: cetyl betaine)

Cocamido propyl betaine

Wherein R has about 9 to about 13 carbon atoms

Cocos nucifera oil acylamino-propyl hydroxy sulfobetaines

Wherein R has about 9 to about 13 carbon atoms,

Other spendable examples of amphoteric surfactants is that formula is RN[CH ₂) _mCO ₂M] ₂And RNH (CH ₂) _mCO ₂The alkyl imino acetate of M and iminodiacetic alkanoate and amino-alkane hydrochlorate, wherein m is 1 to 4, R is C ₈-C ₂₂Alkyl or alkenyl, and M is H, alkali metal, alkaline-earth metal, ammonium or alkanol ammonium.Also comprise imidazoline and ammonium derivative.The instantiation of suitable amphoteric surfactant comprises 3-dodecyl-alanine sodium, 3-dodecyl amino propane sulfonic acid sodium, N-senior alkyl aspartic acid, for example according to United States Patent (USP) 2,438, those of instruction preparation in 091, described document is incorporated herein with way of reference in full; And sell and be described in United States Patent (USP) 2,528 with trade name " Miranol ", and the product in 378, described document is incorporated herein with way of reference in full.Other example of available amphoteric surfactant comprises two acid phosphates, for example cocamidopropyl propyl amide pg dimonium chloride phosphate ester (with trade name Monaquat PTC available from MonaCorp.).Also spendable is the both sexes acetates, for example lauroyl both sexes base oxalic acid disodium, lauroyl both sexes guanidine-acetic acid sodium and their mixture.

Also can use both sexes guanidine-acetic acid salt and two both sexes guanidine-acetic acid salt.

Both sexes guanidine-acetic acid salt

Two both sexes guanidine-acetic acid salt

Both sexes guanidine-acetic acid salt and two both sexes guanidine-acetic acid salt meet described chemical formula structure (above), and wherein R is the aliphatic group with 8 to 18 carbon atoms.M is a cation, for example the ammonium of sodium, potassium, ammonium or replacement.In some embodiments, preferred lauroyl both sexes guanidine-acetic acid sodium, cocos nucifera oil acyl both sexes guanidine-acetic acid sodium, lauroyl both sexes guanidine-acetic acid disodium and cocos nucifera oil acyl two both sexes guanidine-acetic acid disodiums.

Described compositions also can comprise at least a zwitterionic surfactant.The concentration of the zwitterionic surfactant that described compositions comprises by the weight of described surface active agent composition at about .1% to about 50%, about .4% is to about 30%, about .5% is extremely about 25%, about 1% to about 20%, about 2% to about 10% scope.

Be applicable to that the zwitterionic surfactant in the described compositions comprises those that extensively are described as aliphatic quaternary ammonium, Phosphonium and sulfonium compound derivant, wherein aliphatic group can be a straight or branched, and one of them aliphatic substituent group comprises about 8 to about 18 carbon atoms, and one comprises anionic group, for example carboxyl, sulfonate radical, sulfate radical, phosphate radical or phosphonate radical.This type of suitable zwitterionic surfactant can be expressed from the next:

R wherein ²Comprise have about 8 to about 18 carbon atoms, 0 to about 10 ethylene oxide moieties and 0 alkyl, alkenyl or hydroxyalkyl to about 1 glyceryl part; Y is selected from the group of being made up of following: nitrogen, p and s atom; R ³For comprising about 1 alkyl or monohydroxy alkyl to about 3 carbon atoms; When Y was sulphur atom, X was 1, and when Y was nitrogen or phosphorus atoms, X was 2; R ⁴For having about 1 alkylidene or hydroxy alkylidene to about 4 carbon atoms, and Z is group, and is selected from the group of being made up of following: carboxylate radical, sulfonate radical, sulfate radical, phosphonate radical and phosphate groups.

Other is applicable to that the zwitterionic surfactant in the described compositions comprises betanin, described betanin comprises the senior alkyl betanin, for example cocoyl dimethyl carboxymethyl betaine, cocoamidopropyl, coco betaine, lauramido propyl betaine, oil-based betaine, the lauryl dimethyl carboxymethyl betaine, lauryl dimethyl α-carboxyethyl betanin, cetyl dimethyl carboxymethyl betaine, lauryl two-(2-ethoxy) carboxymethyl betaine, stearyl two-(2-hydroxypropyl) carboxymethyl betaine, oil base dimethyl γ-carboxylic CAB, with lauryl two-(2-hydroxypropyl) α-carboxyethyl betanin.Sulfobetaines can be representative by following material: cocoyl dimethyl sulfopropyl betaine, stearyl dimethyl sulfopropyl betaine, lauryl dimethyl sulfoethyl betanin, lauryl two-(2-ethoxy) sulfopropyl betaine etc.; Also can use amido betaine and amino sulfobetaines, wherein RCONH (CH among the present invention ₂) ₃Group is connected on the nitrogen-atoms of betanin.

Cationic surfactant also can be used in the described compositions, but generally be less preferred, and content by the weight of described compositions preferably less than about 5%.

Conditioner

Compositions of the present invention can comprise conditioner, and described conditioner can be used for providing the conditioning beneficial effect to other position of skin, hair and companion animals body.Described conditioner can be independent conditioner, perhaps with surface active agent composition and/or inorganic agent combination.The conditioner concentration that described leave compositions comprises by the weight of described compositions at about .1% to about 95%, about .5% is to about 90%, about 1% to about 85%, about 5% to about 70%, about 10% to about 60%, with about 15% to about 50%, about 18% to about 30%, about 20% to about 25% scope.

The conditioner that can be used among the present invention can comprise: the water solublity conditioner; The oil-soluble conditioner; Conditioning property emulsion; Or this three's any combination or arrangement.Described oil-soluble conditioner is selected from one or more oil-soluble conditioners, so that the weighted arithmetic mean solubility parameter of described oil-soluble conditioner is less than or equal to 10.5.Described water solublity conditioner is selected from one or more water solublity conditioners, so that the weighted arithmetic mean solubility parameter of described water solublity conditioner is greater than 10.5.Will be appreciated that, mathematical definition according to this solubility parameter, for example for the oil-soluble conditioner that comprises two or more chemical compounds, if wherein a kind of chemical compound has the independent solubility parameter greater than 10.5, might obtain required weighted arithmetic mean solubility parameter, promptly be less than or equal to 10.5.On the contrary, for the water solublity conditioner that comprises two or more chemical compounds, be less than or equal to 10.5 independent solubility parameter if wherein a kind of chemical compound has, the weighted arithmetic mean solubility parameter that might obtain to suit is promptly greater than 10.5.

Solubility parameter is that the preparation chemist of ordinary skill is known, and usually as in process for preparation, determining substances compatible and deliquescent guidance.Referring to " SolubilityEffects in Product, Package, Penetration, and Preservation ", Cosmetics and Toiletries, the 103rd volume, the 47th to 69 page (in October, 1988).

The limiting examples of available conditioner comprises and being selected from by the following group that those are formed: siloxanes, the functionality siloxane polymer, the functionality siloxane polymer, fatty acid, fatty acid ester, aliphatic alcohol, ethoxylate, polyol polyester, glycerol, monoglyceride, the glycerol polyester, epidermis hydrocarbon and sebum hydrocarbon, lanoline, straight chain and branched-chain hydrocarbons, silicone oil, silicone gum, vegetable oil, the vegetable oil adduct, hydrogenated vegetable oil, non-ionic polymers, native paraffin, vaseline, the vaseline derivant, synthetic wax, polyenoid belongs to dihydroxylic alcohols, polyenoid belongs to monoesters, polyenoid belongs to polyester, cholesterol, cholesteryl ester, triglyceride, and their mixture.

More particularly, the group of the following composition of the optional freedom of described conditioner: siloxane polymer, the functionality siloxane polymer, paraffin, mineral oil, vaseline, stearyl alcohol, spermol, 16/octadecanol, docosanol, the C10-30 polyester of sucrose, stearic acid, Palmic acid, behenic acid, oleic acid, linoleic acid, myristic acid, lauric acid, ricinoleic acid, stearyl polyoxyethylene (1-100) ether, 16/octodecyl alcohol polyoxyethylene (1-100) ether, cholesterol, cholesteryl ester, glyceryl San behenic acid ester, the glyceryl dipalmitate, the glyceryl monostearate, the trihydroxy tristerin, ceresine, Jojoba wax, lanolin wax, glycol distearate, candelilla wax, Carlow crust wax, Cera Flava and siloxane wax.

Mineral oil (being also referred to as Albolene) is the liquid hydrocarbon mixture that derives from oil.Referring to " Merck Index ", the tenth edition, clauses and subclauses 7048 (the 1033rd page (1983)) and " International Cosmetic Ingredient Dictionary ", the 5th edition, the 415th to 417 page (1993) of the 1st volume.

Vaseline (being also referred to as mineral jelly) is the colloidal state system that comprises non-straight chain solid hydrocarbons and high boiling point liquid hydrocarbon.Referring to " Merck Index ", the tenth edition, clauses and subclauses 7047 (the 1033rd page (1983)); " Drug.Cosmet.Ind. " of Schindler, the 89th, 36 to 37,76,78 to 80,82 pages (1961); " International Cosmetic IngredientDictionary ", the 5th edition, the 537th page (1993) of the 1st volume.

Non-volatile siloxane, for example polydialkysiloxane, poly-diaromatic siloxane and poly-alkaryl siloxanes also are spendable skin conditioning agents.These siloxanes are disclosed in the United States Patent (USP) of authorizing Orr 5,069,897 of December in 1991 announcement on the 3rd.

The conditioner that preferably can be used among the present invention also can comprise conditioning emulsion.Between the leave compositions operating period, described conditioning emulsion can be used for to skin, hair, palm and refer to/and toenail provides the conditioning beneficial effect.As used herein, term " conditioning emulsion " can refer to comprise the inner phase and the combination that comprises the foreign minister of oil-soluble reagent of water solublity conditioner, described inner phase is wrapped quilt by described foreign minister, perhaps as used herein, term " conditioning emulsion " is meant inner phase that comprises oil-soluble reagent and the combination that comprises the foreign minister of water-soluble reagent, and described inner phase is wrapped quilt by described foreign minister.In preferred embodiments, conditioning emulsion also will comprise emulsifying agent.The content of described conditioning emulsion is counted about .01% to about 100% by the weight of described leave compositions, and about .1% extremely about 95%, about 1% to about 90%, 1.5% to about 85%, about 2% to about 80%, about 5% to about 70% and about 10% to about 50%.In a preferred embodiment, described conditioning emulsion comprises (i) and comprises the inner phase of water solublity conditioner as mentioned above and (ii) as mentioned in oil-soluble conditioner part or hereinafter the foreign minister who comprises oil-soluble reagent described in " being used to increase the material of lipoid hardness number " part.In other embodiments, described conditioning emulsion also comprises emulsifying agent, and described emulsifying agent can form the emulsion with described inner phase and foreign minister.Though preferably can form the emulsifying agent of emulsion among the present invention, will be appreciated that in the skin care formulation field, the water solublity conditioner can be by oil-soluble reagent place bag quilt under the emulsifier-free situation with inner phase and foreign minister.

Inorganic agent

Compositions of the present invention can comprise inorganic agent.Between the leave compositions operating period, described inorganic agent can be used for to companion animals skin, hair, palm, ear, refer to/toenail and similarly contain the keratin surface provide the treatment beneficial effect and/or the beauty treatment beneficial effect.Described inorganic agent is suitable for being administered to and contains keratic tissue, and promptly they are applicable to the contact companion animals, and do not have unsuitable toxicity, incompatibility, unstability, atopic reaction etc.

The inorganic agent that can be used among the present invention comprises compositions, described compositions comprises following limiting examples: vitamin, cyclodextrin, zeolite, peptide, sunscreen actives, terpenol, the desquamation active substance (comprise that sulfhydryl compound and zwitterionic surfactant divide combination, and the combination of salicylic acid and zwitterionic surfactant), anti-atrophy active substance, antioxidant/free radical scavenger, flavonoid, antiinflammatory, local anesthetic, chelating agen, antimicrobial and antifungus active substance, skin is consoled and the skin healing active substance, anti-flea class active substance, the active substance of preserving moisture, anti-louse class active substance, other anti-insecticidal active substance, and their mixture.

The inorganic agent concentration that described leave compositions comprises by the weight of described compositions at about .1% to about 95%, about .5% is to about 90%, about 1% to about 85%, about 5% to about 70%, about 10% to about 60%, with about 15% to about 50%, about 18% to about 30%, about 20% to about 25% scope.

Foaming agent

Leave compositions of the present invention can comprise foam.Can use foam to help control the foam volume that produces by the present composition.The concentration of the foam that the leave compositions comprises by the weight of described compositions about 0.01% to about 2%, about 0.05% to about 1.5%, about 0.1% to about 1%, about 0.15% to about 0.7%, about 0.2% to about 0.5% and about 0.25% to about 0.4% scope.

Limiting examples comprises siloxanes, fatty acid, alcohol, hydrophobe and their mixture.

Other limiting examples comprise following these: alcohol, two phenyl gather the hexamethyl siloxanes, poly-cetyl diformazan siloxanes, polydimethylsiloxane, the silylanizing polydimethylsiloxane, dimethiconol, poly-diphenyl dimethyl siloxane, poly-cetyl methylsiloxane, the hexamethyl disiloxane, hexanol, isopropyl alcohol, the oil gold-plating goes out thing, the phenyl disiloxane, the polyphenylene dimethyl siloxane, the polyphenylene trimethicone, polydimethylsiloxane, propanol, silylanizing silicon dioxide, dimethicone, the trimethylsiloxy esters of silicon acis, poly-triphenyl trimethicone, and their mixture.

Other composition

Compositions of the present invention can comprise numerous other optional components, and these annexing ingredients should be pharmaceutically useful." CTFA Cosmetic Ingredient Handbook " second edition (1992) has been described numerous nonlimiting cosmetic compositions and the ingredient that is generally used in the skin protection industry, and described composition is applicable in the present composition.The limiting examples of function class composition is described in the 537th page of this list of references.The example of these and other function class comprises: grinding agent, absorbent, antioxidant, binding agent, bio-additive, buffer agent, extender, chemical addition agent, coloring agent, cosmetics insecticide, denaturant, medicine astringent, external-use analgesic, film former, fragrance components, wetting agent, opacifying agent, pH regulator agent, antiseptic, propellant, Reducing agent and Porcelana Skin Bleaching Agent Porcelana.

What also can be used for this paper is the sense organ component, and for example aromatic, pigment, coloring agent, quintessence oil, skin sensitizer, astringent, skin are consoled agent and skin healing agent.

The compositions that can be used among the present invention also can comprise " fluid ", for example mineral oil, silicone oil of water, monohydric alcohol and polyhydric alcohol (glycerol, propylene glycol, ethanol, isopropyl alcohol etc.), hydrocarbon ils for example with viscosity, and can comprise be dissolved or dispersed in them or except that other component them.

The invention still further relates to the cover box, described cover box comprises leave compositions and container.In addition, the cover box that is used for the companion animals compositions comprises: (a) leave compositions, described compositions comprise total foam volume and are the compositions of about 300mL to about 700mL; (b) wherein comprise the container of described compositions.

Using method

Leave compositions of the present invention preferably locally apply to desired companion animals skin, hair, palm, ear, refer to/toenail and similarly contain the keratin surf zone, present in an amount at least sufficient to provide effectively sending of described leave compositions.Described compositions can be applied directly on the skin, or by using disposable nonwoven implement, cleaning powder puff, bath towel, sponge or other utensil to be administered on the skin indirectly.

Therefore, the invention still further relates to use and clean, nurse one's health and/or handle companion animals skin, hair, palm, ear, refer to/toenail and the similar method that contains the keratin surface by the present composition above-mentioned.

The present invention relates to the using method of leave compositions of the present invention, said method comprising the steps of: (A) the total foam volume of preparation is the leave compositions of about 300mL to about 700mL; (B) product in the step (A) is administered on the companion animals; (C) clean companion animals; (D) randomly wash described companion animals; (E) randomly pat dry with towel.

Not bound by theory, thus the effect that it is believed that product is understood the ability of operation instruction and is used the ability of described product relevant with consumer.Included a whole set of operation instruction comprises the product picture or the diagram of being used, and written explanation.Therefore, the invention still further relates to article of commerce, described article of commerce comprises the container that comprises the leave compositions, when using described leave compositions, it can provide conditioning, cleaning and/or handle beneficial effect to companion animals, and described leave compositions comprises: (a) total foam volume is the compositions of about 300mL to about 700mL; (b) IL-1 α is the described compositions of about 0pg/mL to about 7000pg/mL; Wherein said vessel is useful on conditioning, cleaning and handles the operation instruction of companion animals, and described operation instruction comprises the explanation that routine is used described leave compositions, given described companion animals massage, randomly washes and randomly pat dry with towel.

Preparation method

Leave compositions of the present invention can by be suitable for preparing and prepare any known of required product form or in other words otherwise effective technique prepare.

Method

The foam volume test:

The foam volume of compositions is measured in use with graduated graduated cylinder and slewing.Use 1,000mL is with graduated graduated cylinder, and it increases progressively with 10mL and comes labelling, and from its pedestal inboard to 1, the 000mL mark has 14.5 inches height (for example Pyrex # 2982).Distilled water (100 grams, 25 ℃) is joined and is with in the graduated graduated cylinder.Graduated cylinder is clipped on the rotary apparatus, clamps described graduated cylinder with the center of rotating shaft crosscut band graduated cylinder.The graduated cylinder sidewall that 0.50 gram compositions (feed that the weight sufficient to guarantee is suitable) is higher than certainly waterline from syringe is injected into to be with in the graduated graduated cylinder, and graduated cylinder is covered.When the evaluation and test sample, only use 0.25cc, keep other all situations identical.Change per 18 seconds speed with about 10 and make 20 complete rotations of graduated cylinder rotation, and stop, to finish first rotatable sequence at vertical position.Set intervalometer, the foam that allows to be produced effluxed 15 seconds.Above-mentioned efflux 15 seconds after, by being the foam height of unit record more than pedestal (any water that has been discharged to the bottom that comprises buoyant foam above it) with mL, measure first foam volume, be accurate to the 10mL labelling.

If foam top surface unevenness can see that then the minimum altitude with half plane of structure place of graduated graduated cylinder is first foam volume (mL).Extend to whole graduated cylinder if foam is crossed thick so that comprised one of foam (bubble) or only several foam cell, then needing at least 10 foam cell to come the height at packing space place is first foam volume, is that unit upwards calculates from pedestal equally with mL.Greater than one inch foam cell, no matter where they appear at, and all are designated as the air rather than the foam of not filling on any dimension.If foam top in the pantostrat of himself, by using scale measuring layer thickness, is added to the foam mL number that focuses on herein in the foam mL number that pedestal upwards measures, will accumulates in the foam of being with the graduated cylinder top but not effluxing and be also included within the measurement.The maximum foam height is 1,000mL (even Zong foam height surpasses 1 on the band graduated cylinder, 000mL labelling).After for the first time rotation is finished 30 seconds, begin second rotatable sequence, its speed is identical with first rotatable sequence with the persistent period.After effluxing the time in same 15 seconds, write down second foam volume in the mode identical with the first time.Finish the 3rd sequence in an identical manner and measure the 3rd foam volume, efflux between each identical with the intermittence of measuring.

Foam result after each sequence is added together, and total foam volume of being measured is to measure sums three times that (" mL ") is unit with milliliter.Instantaneous foam volume only is the result behind first rotatable sequence, is unit with mL, i.e. first foam volume.In this test, to compare with the analogous composition of conventional emulsions form, compositions as described herein significantly performance is better.

Friction testing

Described method is measured the change in friction force of untreated hair bunch and the hair of using compositions-treated bunch.Weigh " sled " (～47mm Lx 36mm H x 35mm W) that heavy 510g+/-5% and bottom are coated with froth bed is connected to device for measuring force for example on the Instron, and at one end pressed from both sides and the other end is gone up pulling by the fixed 10g hair of adhesive tape bunch (being about 6 inches) with constant speed.

Used hair for be made into～10 grams send out bunch brown white people hairs for long six inches, it has been cleaned to remove any external dirt.Make then hair bunch in thermostatic chamber in 75 ℃/50% relative humidity (RH) equilibrate overnight down.

Following processing hair bunch: then the 1.0cc compositions is administered on the hair bunch surface, and in sending out bunch friction～30-40 second.Dry then bunch, and be suspended on the frame again, and be positioned over (75 ℃/50% RH) in the thermostatic chamber, with equilibrate overnight.

On the horizontal checkout platform, and combing 2 to 3 times is with directed with hair and remove and tangle with to be measured bunch locating clip.Then " sled " connected and be placed on the hair bunch.By with the speed of about 1cm/s pulling " sled ", measure pulling force (being that unit measures usually with the gram) simultaneously, measure forward (towards the sending out a tip direction) frictional force on sending out bunch.Each strength degree is that " sled " arrives after the constant rate of speed average at least ten numerical value of the interior record of 5cm distance at least.Each bunch carried out minimum five times to be measured.Coefficient of friction is defined as being untreated hair bunch frictional force divided by the average ratio of handling hair bunch frictional force.

Irritated evaluation test

The epiderm skin equivalent is the horn cell multilamellar differentiation culture thing in the growth of liquid-vapor interface place.Behind the top surface ingress of air, form horny layer naturally, with can the whole compositions of local application.

Step:

1. The cultivation of EpiDerm200 culture and processing: obtain EpiDerm200 culture (MatTek), and unpack and be positioned in the 6 hole tissue culturing plates that comprise 1mL/ hole check and analysis medium (Mattek, EPI-100 maintenance/check and analysis medium, free state hydrocortisone).Make tissue culture under the humidity of 37 ℃, 5% CO2 and 90% to 95%, equilibrate overnight in Forma tissue culture device.Sucking-off medium at the bottom of the hole of each culture, and replenish the above-mentioned fresh pre-thermal medium of 900 μ L/ cultures.With the local feed of six cultures, to be identified for the relatively optimum time of contact of all compositionss.After finishing preliminary study,, and replenish the check and analysis medium of the fresh preheating of 900 μ L with medium sucking-off from remaining tissue culture.Then to every kind of compositions of tissue culture partial accession 40 μ L, and be re-injected in tissue culture's device, cultivated 26 hours.After the cultivation, collect the check and analysis medium, measure to carry out IL1 α and IL8.Tissue culture is placed the MTT activity detection analysis.

2. The MTT activity detection analysis: by in 50mL sterilization centrifuge tube, dilute the 5mg/mL MTT concentrated solution (MatTek) of two 2mL test tubes with the MTT diluent (MatTek) of two 8mL test tubes, and the speed with 1000RPM is rotated in the Brinkman centrifuge, prepare the MTT working solution that contains 1mg/mL MTT (Diethylaminoethyl thiazole base diphenyl tetrazolium), to be placed in the tissue culturing plate.Gained supernatant decantation in the new test tube of paper tinsel parcel, and is stored down at 4 ℃ at interval the time in check and analysis.Before specified collection period, be drawn onto in each holes of 24 hole tissue culturing plates by MTT working solution and make itself and equilibrium at room temperature prepare to be used for 24 hole tissue culturing plates of MTT check and analysis 300 μ L.During preparation and check and analysis, make the 24 hole tissue culturing plate lucifuges that comprise the MTT working solution.After specified time of contact, use sterilization spray bottle, (DPBS MatTek) washs each 6 hole tissue culturing plate with the PBS of Dulbecco, and make liquid stream point to 6 hole tissue culturing plate built-in edges and sentence generation vortex in embedding, thereby remove remaining composition.With the upset of each tissue culture and on napkin, pat to remove unnecessary DPBS, to place then each hole of the 24 hole tissue culturing plates that comprise the MTT working solution.After the tissue culture contact back cultivation that only contacts 15 minutes is finished, they are placed MTT solution.After placing MTT, in tissue culture's device, described tissue culture was cultivated three hours.Between culture period, prepare to extract plate, by the MTT extractant (acidifying isopropyl alcohol) of 2mL (MatTek) is drawn into to extract MTT in each hole from tissue culture.After the cultivation, from MTT solution, remove each tissue culture, on napkin, blot, and put in the hole of containing extractant solution.After all tissue cultures are gathered, wrap up tissue culture, extract plate with Parafilm and aluminium foil, place zip shape bag, and put in the refrigerator, until reading.In reading, take out each tissue culture's insert in the slave plate, and its content decantation is returned in the hole of extracting plate.Sucking-off extractant from each hole (200 μ L, twice), and transfer in the flat check and analysis plate in 96 clean holes.Read to use on the plate device MTT extractant as blank at Molecular Devices VMax, read the flat check and analysis plate in 96 clean holes at λ=570nm place.By MTT absorbance reading as follows, to each compositions calculated activity percentage ratio (%).

3. IL1 α ELISA: check and analysis medium freezing preservations under-20 ℃ of collecting from each tissue culture during with collection period and MTT activity detection analysis, until quantitative in IL1 α ELISA.Adopt the scheme of manufacturer, use ELISA cover box (R﹠amp; D system, catalog number (Cat.No.) SLA50) comes check and analysis.Under 1:20 dilution and undiluted situation, evaluation check and analysis medium.Described scheme below is provided.Check and analysis cover box provides all material.

A. reagent preparation:

I. make all reagent and material reach room temperature before use.

Ii. washing buffer: with 480mL MilliQ water, the washing buffer concentrate of dilution 20mL.

Iii.IL1 α reference material: the standard diluent RD5 with 5mL resets IL1 α reference material.In the standard diluent, prepare the reference material diluent of a series of 1:2.

Iv. matrix solution: in 15 minute service time, mix 10mL coloring agent A and coloring agent B.

B. 50 μ L check and analysis diluent RD1C are joined in each hole of culture plate.In each hole, add 200 μ L master samples or sample diluent.At room temperature cultivated 2 hours.

C. the content in the decantation plate, and with the washing buffer washing in 200 μ L/ holes 3 times.Plate is blotted on napkin.

D. in each hole, add 200 μ L conjugates.At room temperature cultivated 1 hour.

E. the content in the decantation plate, and with the washing buffer washing in 200 μ L/ holes 3 times.Plate is blotted on napkin.

F. in each hole, add 200 μ L matrix solutions.At room temperature cultivated 20 minutes.Lucifuge.

G. in each hole, add 50 μ L stop buffers.In 30 minutes, read on the plate device (Molecular Devices), at 450nm place reading at VMax.

H. read plate software (SoftMax, Molecular Devices) by employing, make standard curve coupling 4-parameter logarithmic curve-fitting, and from the parameter that is generated, calculate unknown quantity, determine to derive from the IL1 α concentration of each sample.

I. adopt following formula, IL1 α normalization is become the active percentage ratio (%) that is drawn by the MTT check and analysis, so that loss of activity to be described:

4.IL8 ELISA: check and analysis medium freezing preservations under-20 ℃ of collecting from each tissue culture during with collection period and MTT activity detection analysis, until quantitative in IL8 ELISA.Adopt the scheme of manufacturer, use ELISA cover box (R﹠amp; D system, catalog number (Cat.No.) D8000C) comes check and analysis.Under 1:20 dilution and undiluted situation, evaluation check and analysis medium.Described scheme below is provided.Check and analysis cover box provides all material.

A. reagent preparation:

I. make all reagent and material reach room temperature before use.

Ii. washing buffer: with 480mL MilliQ water, the washing buffer concentrate of dilution 20mL

The iii.IL8 reference material: the standard diluent RD5 with 5mL resets the IL8 reference material.In the standard diluent, prepare the reference material diluent of a series of 1:2.

Iv. matrix solution: in 15 minute service time, mix 10mL coloring agent A and coloring agent B.

B. 100 μ L check and analysis diluent RD1-85 are joined in each hole of culture plate.In each hole, add 50 μ L master samples or sample diluent.At room temperature cultivated 2 hours.

C. the content in the decantation plate, and with the washing buffer washing in 200 μ L/ holes 4 times.Plate is blotted on napkin.

D. in each hole, add 100 μ L conjugates.At room temperature cultivated 1 hour.

E. the content in the decantation plate, and with the washing buffer washing in 200 μ L/ holes 3 times.Plate is blotted on napkin.

F. in each hole, add 200 μ L matrix solutions.At room temperature cultivated 20 minutes.Lucifuge.

G. in each hole, add 50 μ L stop buffers.In 30 minutes, read on the plate device (Molecular Devices), at 450nm place reading at VMax.

H. read plate software (SoftMax, Molecular Devices) by employing, make standard curve coupling 4-parameter logarithmic curve-fitting, and from the parameter that is generated, calculate unknown quantity, determine to derive from the IL8 concentration of each sample.

I. adopt following formula, the IL8 normalization is become the active percentage ratio (%) that is drawn by the MTT check and analysis, so that loss of activity to be described:

Embodiment

Following examples have further described with illustration the embodiment in the protection domain of the present invention.These embodiment that given only are illustrative, and are unintelligible for being limitation of the present invention, because can carry out many changes in the case of without departing from the spirit and scope of protection of the present invention.Except as otherwise noted, all exemplary amount are the concentration by described leave composition weight meter.

Raw material	Embodiment 1 weight %	Embodiment 2 weight %	Embodiment 3 weight %	Embodiment 4 weight %	Embodiment 5 weight %	Embodiment 6 weight %
							Polyoxyethylene (20) isocetyl ether	0.347	0.347	0.347	0.347	0.347	0.347
Polyacrylic acid	0.1	X	0.1	0.10	0.10	0.1
							Propylene glycol	0.15	0.15	0.15	0.15	0.15	0.15
Aromatic	0.015	0.015	0.015	0.015	0.015	0.015
							DMDM Hydantoin	0.2	0.2	0.2	0.2	0.2	0.2
Sodium benzoate	0.2	0.2	0.2	0.2	0.2	0.2
							Poloxamer 184	1.0	1.0	1.0	1.0	1.0	X
Polyoxyethelene 4 sorbitan monostearate sugar alcohol one lauric acid ester	0.5	0.5	0.5	0.5	0.5	1.0
							Poly-divinyl dimethyl siloxane/polydimethylsiloxanecopolymer copolymer	0.3	X	X	X	X	X
Amino-terminated polydimethylsiloxane	X	0.3	X	X	X	X
							Polydimethylsiloxane	X	X	0.3	X	X	X
Dimethiconol	X	X	X	X	X	X
							Siloxanes quaternary ammonium-16	X	X	X	0.3	X	X
The alkyl methyl silicone copolyol	X	X	X	X	0.3	X
							Polydimethylsiloxane	0.1	0.1	0.1	0.1	0.1	0.1
Aloe gel	0.2	0.2	0.2	0.2	0.2	0.2
							Beta-schardinger dextrin-	0.1	0.1	0.1	0.1	0.1	0.1
Triethanolamine	0.1	0.1	0.1	0.1	0.1	0.1
							Polysorbate 20	X	X	X	X	X	X
Oil base polyoxyethylene ether-10	X	X	X	X	X	X
							Laureth succinate disodium sulfonate	X	X	X	X	X	0.5
4-chloro-3, the 5-xylenol	X	X	X	X	X	X
							Laureth-23	X	X	X	X	X	X
Ajidew?NL-50	X	X	X	X	X	X
							Hydroxypropyl	X	X	X	X	X	X
Alkyl glycerol base sodium sulfonate	X	X	X	X	X	X
							C12-C18 alkanoic acid methyl ester-2 sodium sulfonate	X	X	X	X	X	X
Salicylic acid	X	X	X	X	X	X
							Citric acid	X	X	X	X	X	X
The polyalkylene oxide polydimethylsiloxane	X	X	X	X	X	X

Potassium sorbate	X	X	X	X	X	X
							Poloxamer 333	X	X	X	X	X	X
PEG-6 caprylic/capric glyceride	X	X	X	X	X	X
							PPG-12 PEG-50 lanoline	X	X	X	X	X	X
Water	In right amount to 100%	In right amount to 100%	In right amount to 100%	In right amount to 100%	In right amount to 100%	In right amount to 100%

Raw material	Embodiment 7 weight %	Embodiment 8 weight %	Embodiment 9 weight %	Embodiment 10 weight %	Embodiment 11 weight %	Embodiment 12 weight %
							Polyoxyethylene (20) isocetyl ether	0.347	0.347	0.347	0.347	0.347	0.347
Polyacrylic acid	0.1	0.1	0.1	X	0.1	X
							Propylene glycol	0.15	0.15	0.1	0.15	0.15	0.15
Aromatic	0.015	0.015	0.1	0.075	0.015	0.015
							DMDM Hydantoin	0.2	0.2	0.2	X	0.2	0.2
Sodium benzoate	0.2	0.2	X	0.25	0.2	0.2
							Poloxamer 184	1.0	1.0	X	X	1.0	X
Polyoxyethelene 4 sorbitan monostearate sugar alcohol one lauric acid ester	X	X	X	X	0.5	X
							Poly-divinyl dimethyl siloxane/polydimethylsiloxanecopolymer copolymer	X	0.3	X	X	X	0.5
Amino-terminated polydimethylsiloxane	X	X	X	X	X	X
							Polydimethylsiloxane	0.3	X	X	X	X	X
Dimethiconol	X	X	X	X	0.3	X
							Siloxanes quaternary ammonium-16	X	X	X	X	X	X
The alkyl methyl silicone copolyol	X	X	X	X	X	X
							Polydimethylsiloxane	0.1	X	X	X	0.1	X
Aloe gel	0.2	X	0.2	0.2	0.2	0.2
							Beta-schardinger dextrin-	0.1	0.05	0.3	0.05	0.1	0.1
Triethanolamine	0.1	0.2	0.2	0.2	0.1	0.1
							Polysorbate 20	X	X	X	X	X	1.0
Oil base polyoxyethylene ether-10	X	X	X	X	X	0.5
							Laureth succinate disodium sulfonate	X	X	X	X	X	X
4-chloro-3, the 5-xylenol	X	X	0.1	0.1	X	X
							Laureth-23	X	0.25	X	0.25	X	X
Ajidew?NL-50	X	X	0.2	0.4	X	X
							Hydroxypropyl	X	X	3.0	3.0	X	X

Alkyl glycerol base sodium sulfonate	X	X	0.86	0.172	X	X
							C12-C18 alkanoic acid methyl ester-2 sodium sulfonate	X	X	0.25	0.272	X	X
Salicylic acid	X	X	X	0.2	X	X
							Citric acid	X	X	X	0.1	X	X
The polyalkylene oxide polydimethylsiloxane	X	X	0.25	X	X	X
							Potassium sorbate	X	X	0.2	X	X	X
Poloxamer 333	0.5	0.5	X	X	X	X
							PEG-6 caprylic/capric glyceride	X	0.5	X	X	X	X
PPG-12 PEG-50 lanoline	X	0.5	X	X	X	X
							Water	In right amount to 100%	In right amount to 100%	In right amount to 100%	In right amount to 100%	In right amount to 100%	In right amount to 100%

Raw material	Embodiment 13 weight %	Embodiment 14 weight %	Embodiment 15 weight %	Embodiment 16 weight %	Embodiment 17 weight %	Embodiment 18 weight %
							Polyoxyethylene (20) isocetyl ether	0.347	0.347	0.347	0.347	0.347	0.347
Polyacrylic acid	0.1	0.1	0.10	0.1	0.1	0.1
							Propylene glycol	0.15	0.15	0.15	0.15	0.15	0.15
Aromatic	0.015	0.015	0.015	0.015	0.015	0.015
							DMDM Hydantoin	0.2	0.2	0.2	0.2	0.20	0.2
Sodium benzoate	0.2	0.2	0.2	0.2	0.20	0.2
							Poloxamer 184	15.0	25.0	40.0	50.0	60.0	1.0
Polyoxyethelene 4 sorbitan monostearate sugar alcohol one lauric acid ester	5.0	15.0	20.0	25.0	30.0	0.5
							Poly-divinyl dimethyl siloxane/polydimethylsiloxanecopolymer copolymer	0.3	0.3	0.3	0.3	0.3	5.0
Amino-terminated polydimethylsiloxane	X	X	X	X	X	X
							Polydimethylsiloxane	X	X	X	X	X	X
Dimethiconol	X	X	X	X	X	X
							Siloxanes quaternary ammonium-16	X	X	X	X	X	X
The alkyl methyl silicone copolyol	X	X	X	X	X	X
							Polydimethylsiloxane	2.0	2.0	2.0	2.0	2.0	0.1
Aloe gel	0.2	0.2	0.2	0.2	0.2	0.2
							Beta-schardinger dextrin-	0.1	0.1	0.1	0.1	0.1	0.1
Triethanolamine	0.1	0.1	0.1	0.1	0.1	0.1
							Polysorbate 20	X	X	X	X	X	X

Oil base polyoxyethylene ether-10	X	X	X	X	X	X
							Laureth succinate disodium sulfonate	X	X	X	X	X	X
4-chloro-3, the 5-xylenol	X	X	X	X	X	X
							Laureth-23	X	X	X	X	X	X
Ajidew?NL-50	X	X	X	X	X	X
							Hydroxypropyl	X	X	X	X	X	X
Alkyl glycerol base sodium sulfonate	X	X	X	X	X	X
							C12-C18 alkanoic acid methyl ester-2 sodium sulfonate	X	X	X	X	X	X
Salicylic acid	X	X	X	X	X	X
							Citric acid	X	X	X	X	X	X
The polyalkylene oxide polydimethylsiloxane	X	X	X	X	X	X
							Potassium sorbate	X	X	X	X	X	X
Poloxamer 333	X	X	X	X	X	X
							PEG-6 caprylic/capric glyceride	X	X	X	X	X	X
PPG-12 PEG-50 lanoline	X	X	X	X	X	X
							Water	In right amount to 100%	In right amount to 100%	In right amount to 100%	In right amount to 100%	In right amount to 100%	In right amount to 100%

Raw material	Embodiment 19 weight %	Embodiment 20 weight %	Embodiment 21 weight %	Embodiment 22 weight %	Embodiment 23 weight %	Embodiment 24 weight %
							Polyoxyethylene (20) isocetyl ether	0.347	0.347	0.347	0.347	0.347	0.347
Polyacrylic acid	0.1	0.1	0.1	0.1	0.1	0.1
							Propylene glycol	0.15	0.15	0.15	0.15	0.15	0.15
Aromatic	0.015	0.015	0.015	0.015	0.015	0.015
							DMDM Hydantoin	0.2	0.2	0.2	0.2	0.2	0.2
Sodium benzoate	0.2	0.2	0.2	0.2	0.2	0.2
							Poloxamer 184	1.0	1.0	1.0	1.0	1.0	1.0
Polyoxyethelene 4 sorbitan monostearate sugar alcohol one lauric acid ester	0.5	0.5	0.5	0.5	0.5	0.5
							Poly-divinyl dimethyl siloxane/polydimethylsiloxanecopolymer copolymer	20.0	50.0	75.0	0.3	0.3	0.3
Amino-terminated polydimethylsiloxane	X	X	X	X	X	X
							Polydimethylsiloxane	X	X	X	X	X	X
Dimethiconol	X	X	X	X	X	X
							Siloxanes quaternary ammonium-16	X	X	X	X	X	X

The alkyl methyl silicone copolyol	X	X	X	X	X	X
							Polydimethylsiloxane	0.1	0.1	0.1	0.1	0.1	0.1
Aloe gel	0.2	0.2	0.2	5.0	20.0	50.0
							Beta-schardinger dextrin-	0.1	0.1	0.1	0.1	0.1	0.1
Triethanolamine	0.1	0.1	0.1	0.1	0.1	0.1
							Polysorbate 20	X	X	X	X	X	X
Oil base polyoxyethylene ether-10	X	X	X	X	X	X
							Laureth succinate disodium sulfonate	X	X	X	X	X	X
4-chloro-3, the 5-xylenol	X	X	X	X	X	X
							Laureth-23	X	X	X	X	X	X
Ajidew?NL-50	X	X	X	X	X	X
							Hydroxypropyl	X	X	X	X	X	X
Alkyl glycerol base sodium sulfonate	X	X	X	X	X	X
							C12-C18 alkanoic acid methyl ester-2 sodium sulfonate	X	X	X	X	X	X
Salicylic acid	X	X	X	X	X	X
							Citric acid	X	X	X	X	X	X
The polyalkylene oxide polydimethylsiloxane	X	X	X	X	X	X
							Potassium sorbate	X	X	X	X	X	X
Poloxamer 333	X	X	X	X	X	X
							PEG-6 caprylic/capric glyceride	X	X	X	X	X	X
PPG-12 PEG-50 lanoline	X	X	X	X	X	X
							Water	In right amount to 100%	In right amount to 100%	In right amount to 100%	In right amount to 100%	In right amount to 100%	In right amount to 100%

Raw material	Embodiment 25 weight %
		Polyoxyethylene (20) isocetyl ether	0.347
Polyacrylic acid	0.1
		Propylene glycol	0.15
Aromatic	0.015
		DMDM Hydantoin	0.2
Sodium benzoate	0.2
		Poloxamer 184	1.0
Polyoxyethelene 4 sorbitan monostearate sugar alcohol one lauric acid ester	0.5
		Poly-divinyl dimethyl siloxane/polydimethylsiloxanecopolymer copolymer	0.3
Amino-terminated polydimethylsiloxane	X
		Polydimethylsiloxane	X
Dimethiconol	X

Siloxanes quaternary ammonium-16	X
		The alkyl methyl silicone copolyol	X
Polydimethylsiloxane	0.1
		Aloe gel	75.0
Beta-schardinger dextrin-	0.1
		Triethanolamine	0.1
Polysorbate 20	X
		Oil base polyoxyethylene ether-10	X
Laureth succinate disodium sulfonate	X
		4-chloro-3, the 5-xylenol	X
Laureth-23	X
		Ajidew?NL-50	X
Hydroxypropyl	X
		Alkyl glycerol base sodium sulfonate	X
C12-C18 alkanoic acid methyl ester-2 sodium sulfonate	X
		Salicylic acid	X
Citric acid	X
		The polyalkylene oxide polydimethylsiloxane	X
Potassium sorbate	X
		Poloxamer 333	X
PEG-6 caprylic/capric glyceride	X
		PPG-12 PEG-50 lanoline	X
Water	In right amount to 100%

Embodiment 1 to 25

Can use conventional preparation and hybrid technology to prepare embodiment 1 to 25.

Should be appreciated that each the greatest measure limit that provides in whole description comprises the numerical value limit that each is lower, just low numerical value limit like this is to write out clearly equally in this article.Each the minimum value limit that provides in whole description comprises each high value limit, and just high value limit like this is to write out clearly equally in this article.Each numerical range that provides in whole description comprises each the narrower numerical range that drops in this broader numerical, and just narrower numerical range like this is to write out clearly equally in this article.

Except as otherwise noted, all umbers in the description of this paper, embodiment and claims, ratio and percentage number average by weight, and all numerical rangies conventional degree of accuracy of all using this area to provide.

The relevant portion of the document that all are quoted in detailed Description Of The Invention all is incorporated herein with way of reference.Quoting of any document is all unintelligible for admitting that it is a prior art of the present invention.When any implication of term in any implication of term among the present invention or definition and the file of introducing for your guidance or when defining contradiction, should obey the implication or the definition of giving this term in the present invention.

Though illustrated and described specific embodiments of the present invention, it will be apparent to one skilled in the art that and under the situation that does not deviate from spirit and scope of the invention, can make various other changes and modification.Therefore, claims all such changes and modification of being intended to be included in the scope of the present invention.

Claims (16)

1. leave companion animals compositions, described compositions is characterised in that and comprises: have 300mL to 700mL, 310mL to 600mL, 315mL to 500mL, 320mL to 400mL, the compositions of the total foam volume of 325mL to 380mL.

2. leave companion animals compositions as claimed in claim 1, described compositions also comprises surfactant component.

3. leave companion animals compositions as claimed in claim 2, described compositions comprises the described surface active agent composition by the weight .5% to 95% of described compositions.

4. as each described leave companion animals compositions in the claim 1,2 and 3, wherein said surface active agent composition is selected from the group of being made up of following: anion surfactant, non-ionic surface active agent, amphoteric surfactant, cationic surfactant, soap and their mixture; Wherein said anion surfactant is selected from the group of being made up of following: sarcosinate, sulfate, ethoxylated sulfate, sulfonate, glyceryl sulfonate, isethionate, phosphate, taurate, lactate, glutamate, Glu, soap, sulfosuccinate, ethoxylation sulfosuccinate and their mixture; Wherein said non-ionic surface active agent is selected from the group of being made up of following: alkyl androstanediol, poly glucoside, polyhydroxy fatty acid amide, alkoxy fatty acid ester, sugar ester, ethoxylation ester, glycerine ester, ethoxylate, propoxylate, PEG/PPG copolymer, glyceride, sorbitan and their mixture; Wherein said amphoteric surfactant is selected from the group of being made up of following: amine oxide, betanin, sulfobetaines, hydroxyl sulfo betaine, alkyl imino acetate, iminodiacetic alkanoate, amino-alkane hydrochlorate and their mixture.

5. the described leave companion animals of each claim compositions as described above, described compositions also comprises conditioner, and described conditioner is selected from the group of being made up of following: siloxane polymer, the functionality siloxane polymer, fatty acid, fatty acid ester, aliphatic alcohol, ethoxylate, polyol polyester, glycerol, monoglyceride, the glycerol polyester, epidermis hydrocarbon and sebum hydrocarbon, lanoline, straight chain and branched-chain hydrocarbons, vegetable oil, the vegetable oil adduct, hydrogenated vegetable oil, non-ionic polymers, native paraffin, vaseline, the vaseline derivant, synthetic wax, polyenoid belongs to dihydroxylic alcohols, polyenoid belongs to monoesters, polyenoid belongs to polyester, cholesterol, cholesteryl ester, triglyceride, and their mixture.

6. the described leave companion animals of each claim compositions as described above, described compositions also comprises inorganic agent, and described inorganic agent is selected from the group of being made up of following: vitamin, cyclodextrin, zeolite, peptide, terpenol, the desquamation active substance, anti-atrophy active substance, antioxidant, the class flavane, antiinflammatory, local anesthetic, chelating agen, anti-microbial active matter, antifungus active substance, console active substance, the healing active substance, the active substance of preserving moisture, anti-flea class active substance, anti-louse class active substance, other anti-insecticidal active substance, and their mixture.

7. the described leave companion animals of each claim compositions as described above, described compositions also comprises foam.

8. leave companion animals compositions, described compositions comprises: have 0pg/mL to 7000pg/mL, 70pg/mL to 6000pg/mL, 90pg/mL to 5000pg/mL, the compositions of the IL1 α of 100pg/mL to 4000pg/mL.

9. leave companion animals compositions as claimed in claim 8, described compositions also comprises surfactant component.

10. leave companion animals compositions as claimed in claim 9, described compositions comprises the described surface active agent composition by the weight .5% to 95% of described compositions.

11. as each described leave companion animals compositions in claim 9 and 10, wherein said surface active agent composition is selected from the group of being made up of following: anion surfactant, non-ionic surface active agent, amphoteric surfactant, cationic surfactant, soap and their mixture; Wherein said anion surfactant is selected from the group of being made up of following: sarcosinate, sulfate, ethoxylated sulfate, sulfonate, glyceryl sulfonate, isethionate, phosphate, taurate, lactate, glutamate, Glu, soap, sulfosuccinate, ethoxylation sulfosuccinate and their mixture; Wherein said non-ionic surface active agent is selected from the group of being made up of following: alkyl androstanediol, poly glucoside, polyhydroxy fatty acid amide, alkoxy fatty acid ester, sugar ester, ethoxylation ester, glycerine ester, ethoxylate, propoxylate, PEG/PPG copolymer, glyceride, sorbitan and their mixture; Wherein said amphoteric surfactant is selected from the group of being made up of following: amine oxide, betanin, sulfobetaines, hydroxyl sulfo betaine, alkyl imino acetate, iminodiacetic alkanoate, amino-alkane hydrochlorate and their mixture.

12. the described leave companion animals of each claim compositions as described above, described compositions also comprises conditioner, and described conditioner is selected from the group of being made up of following: siloxane polymer, the functionality siloxane polymer, fatty acid, fatty acid ester, aliphatic alcohol, ethoxylate, polyol polyester, glycerol, monoglyceride, the glycerol polyester, epidermis hydrocarbon and sebum hydrocarbon, lanoline, straight chain and branched-chain hydrocarbons, vegetable oil, the vegetable oil adduct, hydrogenated vegetable oil, non-ionic polymers, native paraffin, vaseline, the vaseline derivant, synthetic wax, polyenoid belongs to dihydroxylic alcohols, polyenoid belongs to monoesters, polyenoid belongs to polyester, cholesterol, cholesteryl ester, triglyceride, and their mixture.

13. the described leave companion animals of each claim compositions as described above, described compositions also comprises inorganic agent, and described inorganic agent is selected from the group of being made up of following: vitamin, cyclodextrin, zeolite, peptide, terpenol, the desquamation active substance, anti-atrophy active substance, antioxidant, the class flavane, antiinflammatory, local anesthetic, chelating agen, anti-microbial active matter, antifungus active substance, console active substance, the healing active substance, the active substance of preserving moisture, anti-flea class active substance, anti-louse class active substance, other anti-insecticidal active substance, and their mixture.

14. the described leave companion animals of each claim compositions as described above, described compositions also comprises foam.

15. a leave companion animals compositions, described compositions comprises: the compositions with the total foam volume of 300mL to 700mL;

Described compositions has the IL1 α of 0pg/mL to 7000pg/mL; And

Described compositions has 1.2 to 2 coefficient of friction.

16. an article of commerce, described article of commerce comprises container, and described container comprises leave companion animals compositions, and described compositions can provide conditioning, cleaning and handles beneficial effect and comprise when being applied to companion animals:

(a) has the compositions of the total foam volume of 300mL to 700mL;

(b) described compositions has the IL1 α of 0pg/mL to 7000pg/mL;

Wherein said vessel is useful on conditioning, cleans and handles the operation instruction of described companion animals, and described operation instruction comprises the explanation to washing, give described companion animals massage routinely and randomly patting dry with towel.