CN101430337A - Liquid dispensing tip with reservoir - Google Patents

Liquid dispensing tip with reservoir Download PDF

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Publication number
CN101430337A
CN101430337A CNA200810172994XA CN200810172994A CN101430337A CN 101430337 A CN101430337 A CN 101430337A CN A200810172994X A CNA200810172994X A CN A200810172994XA CN 200810172994 A CN200810172994 A CN 200810172994A CN 101430337 A CN101430337 A CN 101430337A
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CN
China
Prior art keywords
container
contrast solution
territory
fluid
liquid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CNA200810172994XA
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Chinese (zh)
Inventor
R·达托
K·梁
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LifeScan Scotland Ltd
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LifeScan Scotland Ltd
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Application filed by LifeScan Scotland Ltd filed Critical LifeScan Scotland Ltd
Publication of CN101430337A publication Critical patent/CN101430337A/en
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0272—Dropper bottles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00—Closures with filling and discharging, or with discharging, devices
    • B65D47/04—Closures with discharging devices other than pumps
    • B65D47/06—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages
    • B65D47/18—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages for discharging drops; Droppers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/08—Ergonomic or safety aspects of handling devices
    • B01L2200/087—Ergonomic aspects
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B01L2300/047—Additional chamber, reservoir

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Closures For Containers (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Devices For Use In Laboratory Experiments (AREA)

Abstract

The present invention includes devices for containing and dispensing liquid solutions. The devices of the invention increase ease of sample volume control and, hence, application thereof while minimizing any sample spillage or fluid migration up the side of the dispensing tip. Furthermore, the devices provide ensure adequate sample volume.

Description

The liquid distribution tip that has hydraulic accumulator
Technical field
The present invention relates to be used to hold device with dispense liquid.
Background technology
In a lot of medical treatment and laboratory applications, the liquid reagent that is necessary to provide or bestow the potion liquid reagent or accurately measures dosage, for example medicine or reactant.Need reactant fluid a kind of such of accurate amount to be applied as the system that patient is used for measuring the body analysis thing of physiological fluid.This type systematic generally includes the test-strips that contains reactant material, and biological samples puts on this reactant material.The analyte concentration that each instrument is configured to receive these test-strips and determines sample.Before using these instrument and test-strips, utilize several different methods that it is checked usually, wherein use the monitoring reagent that often is called contrast solution (control solution) to test the accuracy and the effect of test-strips.
Contrast solution often is packaged in and has in the plastics or glass container that distribute the end, and this distribution end disposes little opening at the tapered end place, can distribute coarse relatively contrast solution drop from this little opening by the extruding bottle.Usually, be difficult to accurately control amount from the contrast solution of this type of container allocation.Although it is rapid to be used for the progress of the system of Measurement and analysis substrate concentration and device, the contrast solution that uses with these ASs and device hold and the distribution field in progress limited.Market container of control solution on sale has the conical distributor tip usually, and this conical distributor tip need to be applied to the diagnostic test strip of a large amount of (for example, 5 to 20 microlitres) contrast solutions reliably.Yet when distributing the required smaller size smaller of current more advanced test-strips (it uses less than 1 microlitre), this type of container is just than out of true.
To reach the sub-micro premium on currency flat along with the volume of sample demand of some market test-strips on sale, and excessive contrast solution may be sent in existing conical distributor tip, thereby make troubles and worry for the user.May be difficult to a big contrast solution that drips is accurately guided to the reaction zone of test-strips and also keeps the bottle of contrast solution to be in pressure simultaneously.For elderly patients or those patients who has one's fingers all thumbs, especially true.Because test-strips can not the too much contrast solution of absorption and distribution, so too much solution can overflow.Because it is red with simulate blood realistically, so this especially is a problem that the color of contrast solution is generally.
Description of drawings
Fig. 1 shows the example of the prior art container be used to hold and distribute contrast solution.
Fig. 2 is the low coverage skeleton view of the container of Fig. 1, shows that wherein cap is removed.
Fig. 3 is the low coverage cut-open view of the container of Fig. 2 A-A ' along the line intercepting.
Fig. 4 is the skeleton view of the container of Fig. 1 to 3, and visible its is in upside down position among the figure.
Fig. 5 is the side plan view of exemplary fluid dispense container according to an embodiment of the invention.
Fig. 6 is the cut-open view along the line B-B ' intercepting of Fig. 5, and it shows the exemplary embodiment according to the inner structure of container of the present invention.
Fig. 7 is the cut-open view that is similar to Fig. 6, and it shows the container that is in upside down position at present that contrast solution is housed in the hydraulic accumulator.
Fig. 8 is the low coverage cut-open view of container according to another embodiment of the present invention.
Fig. 9 is the low coverage cut-open view according to first embodiment of the distribution tip of Fig. 8 of the present invention.
Figure 10 is the low coverage cut-open view according to second embodiment of the distribution tip of Fig. 8 of the present invention.
Figure 11 is the cut-open view of container according to another embodiment of the present invention.
Figure 12 is the low coverage cut-open view that specialized designs becomes the exemplary embodiment of the cap of cooperating mutually with an embodiment of fluid distribution tip of the present invention.
Figure 13 is the low coverage cut-open view that specialized designs becomes another exemplary embodiment of the cap of cooperating mutually with another embodiment of fluid distribution tip of the present invention.
Embodiment
In the following description, will be applied as background with analyte concentration measurement and set forth the present invention, and be to be that background is set forth the present invention specifically with concentration of glucose in the blood.Yet, this is not to be intended to restrictive, it will be understood by those skilled in the art that these devices, system and method can be used for measuring other physical characteristics and chemical characteristic (comprising blood cholesterol levels without limitation) and other relate to the biological substance (it comprises urine, saliva etc. without limitation) that uses reactant.Similarly, the present invention can be used for also needing conveniently to provide other materials or the reagent of exact dose.
Fig. 1 is the simplified perspective view of market fluid-distributing container on sale 2, but it comprises main body 4 and withdraw-type cap 6.Alternatively, cap 6 is screwed when not using alternatively to main body 4 or is buckled on the main body 4, so that distribution tip (invisible among Fig. 1) keeps clean.Cap 6 also helps prevent fluid to overflow from container between storage or delivery period or leaks.The liquid control solution that container 2 keeps a certain amount of (usually in about scope of 3 to 5ml), thus can provide the common sustainable use of user about 3 months about 100 to 200 dosage.
Container body 4 can be made of deformable plastic.Yet other container materials (for example glass) that are fit to can be used for container body 4, and therefore are intended to these container materials are covered by among the present invention.Although will use term " container " in full, also use other terms interchangeably, for example bottle or bottle, and therefore for this application purpose, be intended to make term " container " comprise these terms.What those skilled in the art should also be clear that is that this type of container can be used for distributing other liquid except that contrast solution, although will mainly be set forth in the application that distributes the contrast solution aspect herein.
Fig. 2 is the low coverage skeleton view of the container 2 of Fig. 1, and demonstration cap 6 is removed to represent from container body 4 among the figure at present: outstanding neck 10, and it has the optional screw thread 12 that is designed for reception cap 6; With nozzle shape distribution tip 8, it comprises the small-sized distribution outlet 14 that is positioned at the distribution tip place.Fig. 3 is the low coverage cut-open view of A-A ' along the line intercepting of the prior art container 2 of Fig. 2, and it shows that container body 4 comprises the internal cavities 16 that holds fluid to be allocated, the neck 10 that has optional screw thread 12 and distribution tip 8; Distribution tip 8 has represented inner truncated conical configuration 18 at present, this truncated conical configuration 18 forms the passage that narrows down gradually 20 that leads to small-sized outlet 14, and this passage 20 provides reservoir cavity 16 to be communicated with direct fluid between the external environment condition.
Fig. 4 is another skeleton view of the container 2 among Fig. 1 to Fig. 3, and it shows that at present container 2 is in upside down position, and this upside down position is the exemplary position of distributing a contrast solution liquid between the normal operating period from container 2.Fig. 4 comprises the identical feature of having set forth among a lot of and Fig. 2 and Fig. 3 of feature, and further comprises and be shown as the drop 22 of emerging from the 8 interior outlets 14 of nozzle-like distribution tip.The exemplary test strip 24 that also shows the simplification that has sample receiving area 26 among Fig. 4.
Referring now to Fig. 1 to 4, when patient plans to use contrast solution, use at first usually screw action or for example the optional action of push pull maneuver remove cap 6 from container body 4.Then, tilt container main body 4 is so that remain on several centimeters of 26 tops, sample receiving area of new test-strips 24, position for example shown in Figure 4 with distribution tip 8.Then, may need the user that container body 4 is applied slight squeeze pressure, so that from container 2, distribute contrast solution to drip 22 via the outlet 14 that is communicated with the external environment condition fluid.Drop 22 is at first emerged from exporting 14, owing to liquid the intrinsic capillary attraction on surface is assembled then and be suspended on subsequently distribution tip 8 closely on outlet 14 outer surface region.This suspension or the drop that dangles can throw into question, and can contain relatively large liquid because such dropping liquid drips, and this itself is exactly a problem when wishing to distribute very small amount of liquid.
For implementing control solution test, the user makes the sample receiving area 26 of the close more test-strips 24 of drop 22 then.When forming contact, fluid is brought in the reaction chamber of test-strips 24 because of capillary action.
Container 2 and be imperfect from the step of container 2 distributing fluids (for example contrast solution).At first, container is repeated open for prolonged period of time, repeatedly contrast solution is exposed to the pollutant on airborne pollutant and each surface (for example may carry user's finger of pollutant) thus.Because the user of contrast solution often has one's fingers all thumbs, thus they may search cap 6 and/or cap 6 is got rid of, thereby further pollute contrast solution that stores within it and the test result that makes the mistake potentially.If determine that contrast solution is contaminated, then must abandon whole container of control solution and open new container, thereby increase user's cost.
In addition, the container of control solution 2 of this type of prior art can have problems, and this is because relatively large like this contrast solution is provided, so the effect of contrast solution may be just expired before most of contrast solution uses, this has also increased treatment patient's cost.The storage life that is sealed in the contrast solution in the former container is about 1 year to 2 years usually, in case but the user opens container 2, and then storage life will promptly drop to only some months owing to above-mentioned pollution problem.In addition, the user may not be put back into cap 6 on the container body 4 after the use.No matter be to forget wittingly or by mistake cap 6 is put back on the container body 4, allow distributing nozzle be exposed to atmosphere and all can cause the contrast solution evaporation, thereby change the relative concentration of effective constituent, the numerical value that this may make the mistake.
In addition, be difficult to from then on plant in the prior art container 2 accurately and distribute exactly desired contrast solution volume.The amount of being distributed depends on the user to a great extent, because user's possibility is owing to the excessive compression container has applied too many contrast solution, or may be owing to the not enough solution that applies very little of extruding.The contrast solution fluid also can contain a spot of surfactant that is used to promote that test-strips is filled, and adds surfactant and can reduce surface tension, thereby cause contrast solution to show climbing up the tendency of the sidepiece of distribution tip 8.This can make that the user is difficult to contrast solution is accurately guided on the receiving area 26 of test-strips 24.
Fig. 5 is the side plan view of exemplary fluid dispense container 100 according to an embodiment of the invention.The fluid-distributing container of Fig. 5 comprises container body 102, has the neck 104 of optional screw thread 106, nozzle-like distribution tip 108, sleeve 110.The profile line of the line B-B ' indication section shown in Figure 6 among Fig. 5.Although do not show among the figure, but estimate that container 100 comprises the cap that is similar to cap shown in Figure 16, this cap can utilize screw thread 106 to be threadedly coupled to the neck 104 of container body 102 alternatively, yet for example the optional means of attached this cap of sucking fit it will be apparent to those skilled in the art.
Fig. 6 is the cut-open view along the line B-B ' intercepting of Fig. 5, it shows at present exemplary embodiment of the inner structure of container 100, and this container comprises container body 102, has the neck 104 of optional screw thread 106, nozzle-like or convergent shape distribution tip 108, sleeve 110, cavity area 112, the conical butt inner passage 114 that narrows down gradually, small-sized outlet 116 and hold territory, liquid zone 118 around outlet 116.Hydraulic accumulator 118 is formed by the border of sleeve 110.
Fig. 7 is the cut-open view that is similar to Fig. 6, and it shows that at present container 100 is in upside down position, and this upside down position is in order to distribute the exemplary position of contrast solution drop between the normal operating period of container 100.Fig. 7 comprises much before about Fig. 5 and the described similar elements of Fig. 6, and shows at present in the cavity 112 of container body 102 and have liquid 120.
Referring now to Fig. 5, Fig. 6 and Fig. 7, target provides and fill the required enough fluid volumes of test-strips under the situation of not overflowing.Be attached to distribution tip 108 by for example sleeve 110 of smallclothes cylindrical tube, can improve the user distribute the control of contrast solution from conventional vessel.Sleeve 100 is set the hydraulic accumulator 118 with fixing and predetermined volume is provided, thereby make and be easy to distribute required contrast solution amount more.In addition, sleeve 110 can make applying for the user of contrast solution be more prone to, and is described to hanging the needs of drop because it has been eliminated with reference to Fig. 4.
In fact, the user only needs squeeze receptacle slightly, just can fill to hold territory, liquid zone 118 around the outlet 116 that is centered on by sleeve 110.The user can realize above-mentioned action and simultaneously container 100 is held in vertical position that this is that squeeze receptacle main body 102 just can force contrast solution to pass through passage 114 and flow out via outlet 116 because may only need slightly.Roughly using in the vertical position, will allow the user to see clearly that contrast solution moves into and hold territory, liquid zone 118 and fill and hold territory, liquid zone 118.Alternatively, the user can be inclined to container 100 almost inverted position as shown in Figure 7, so that distributing fluids 120 flows out by the passage 114 that narrows down gradually and via outlet 116, thereby allows fluid to arrive the extreme higher position in holding territory, liquid zone 118.Then, volume required contrast solution fluid 120 will remain in the border of sleeve pipe 110 by capillary action.The required volume of volume by making hydraulic accumulator 118 and test-strips is complementary, and the present invention has eliminated the waste of contrast solution.
Sleeve 110 provides extended area or has held the territory, liquid zone, and contrast solution 120 can be inserted and remain in this zone by capillary action, makes the receiving unit 26 of the end engaged test bar 24 of sleeve 110 up to the user.When forming between the sample receiving unit 26 of test-strips 24 and the edge that holds territory, liquid zone 118 when contacting, contrast solution just can be brought into test-strips 24 because of capillary action.Hold territory, liquid zone 118 and aspect size, be arranged to only keep filling the required contrast solution volume of test-strips.In case test-strips is communicated with the contrast solution fluid, then sample is filled and just can be finished by capillary action, thereby has reduced the possibility that contrast solution overflows.
In being attached to the simple sleeve 110 of distribution tip 108, provide extended area or " holding liquid " zone 118 will allow temporarily to store volume required contrast solution.This has simplified user's the program that applies, and makes desired nimble property minimum.
Fig. 8 is the low coverage cut-open view of container 200 according to another embodiment of the present invention, and it comprises container body 202, has the neck 204 of optional screw thread 206, monoblock type distribution tip 208, the passage that narrows down gradually 214 and the expansion of leading to outlet 216 hold territory, liquid zone 218.Fig. 8 provides the container 200 of another exemplary embodiment according to the present invention, and it is applicable to the liquid of distribution such as contrast solution.According to present embodiment, distribution tip 208 can integrally be made, and has eliminated the described extra or independent ferrule element 110 about Fig. 5 to Fig. 7 thus.The monoblock type manufacturing can have many good qualities, and has for example reduced complicacy, time and cost.Can use suitable technology (for example, injection moulding) to make distribution tip 208.This type of technology also can provide the advantage of extensive manufacturing capacity.
The distribution tip 208 of Fig. 8 comprises utilization outlet 216 inner passages that narrow down gradually 214 that are communicated with the external environment condition fluid (being similar to the passage 114 of Fig. 6 and Fig. 7).In this embodiment, passage 214 can be annular, and with respect to the axis concentric alignment of fluid egress point 216.The outer surface that the user applies pressure to container body 202 will make fluid emerge and fill expansion and hold territory, liquid zone 218 by exporting 216.The size of the comparable narrow inner passage 214 of the expansion cardinal principle size of opening 218 in holding the territory, liquid zone is big 5 to 20 times.According to the present invention, expansion is held territory, liquid zone 218 and is designed for holding the required contrast solution volume in receiving area of filling test-strips, so that the user implements control solution test.
Fig. 8 shows that foursquare expansion holds territory, liquid zone 218, and its further details provide in conjunction with Fig. 9 and Figure 10.Figure 11 shows similarly but is that territory, liquid zone 318 is held in circle or semicircular expansion.The exemplary embodiment that provides among Fig. 8 and Figure 11 is intended to be used to purely show embodiments of the invention, and those skilled in the art should be clear that, the territory, liquid zone is held in the expansion that can envision virtually any size and shape, for example cylindrical, taper shape or semisphere hydraulic accumulator, and therefore intention is contained in these shapes among the present invention.
Fig. 9 is the low coverage cut-open view of the distribution tip 208 of Fig. 8, and it comprises fluid egress point 216 and has diameter d 1With height h 1Expansion hold territory, liquid zone 218.Figure 10 is the low coverage cut-open view of the distribution tip 208 of Fig. 8, and it comprises outlet 216 and has diameter d 2With height h 2Expansion hold territory, liquid zone 218.
Fig. 9 and Figure 10 provide two exemplary embodiments according to the distribution tip 208 of Fig. 8 of the present invention, and the difference of these two exemplary embodiments is to expand relative diameter (d) and height (h) size of holding territory, liquid zone 218.Fig. 9 shows expansion and holds territory, liquid zone 218, and it can have in about scope of 1 to 4mm and more generally near the diameter d of 2mm 1, and in about scope of 1 to 2mm and more generally near the height h of 1.6mm 1These sizes provide the volume capacity that is about 5 μ L in this zone, and can suitably be set to hold still less or bigger volume aspect size.
Second embodiment that holds territory, liquid zone 218 that provides among Figure 10 has in about scope of 1 to 5mm and more generally near the diameter d of 3mm 2, and in about scope of 0.5 to 1.5mm and more generally near the height h of 0.7mm 2The same specialized designs of the size of this second embodiment becomes to be used to keep the contrast solution of about 5 μ L.
The embodiment of the distribution tip that provides among Fig. 9 and Figure 10 can temporarily keep enough contrast solution amounts separately, prepare to test also thereby make the sample receiving unit of the new test-strips of edge contact of holding territory, liquid zone 218 up to the user, thereby make fluid be brought into the reaction chamber of test-strips by capillary action.Hold territory, liquid zone 218 and temporarily keep fluid, thereby allow the user that test-strips is contacted with the container that is in vertical position, perhaps alternatively, the user may like that container is inverted into the user and more cosily contrast solution is assigned to suitable angle on the test-strips.Should be clear that another advantage of the present invention is to use vertical container to distribute contrast solution.
According to the application that contrast solution or other fluid reagents used, but the volume in territory, liquid zone is held in specialized designs expansion of the present invention, and this volume can be in the scope of 100nL to 200 μ L.For the contrast solution that uses on the test strip sensors of detection of analytes that is used for blood-glucose for example and measurement, the volume of hydraulic accumulator is usually in the scope of about 1 to 20 μ L.Therefore, the diameter in territory, liquid zone is held in expansion can be usually in about scope of 1 to 10mm, and more generally in about scope of 2 to 4mm.Similarly, expansion is held the degree of depth in territory, liquid zone (perhaps the height in territory, liquid zone is held in expansion, the h that shows respectively as Fig. 9 and Figure 10 1And h 2) can be usually in about scope of 0.5 to 5mm, and more generally in about scope of 1 to 2mm.Providing under the situation of numerical range, it should be understood that any setting or the intermediate value of the upper limit of this scope and each intermediate value between the lower limit and this specialized range all comprises in the present invention.
Figure 11 is the cut-open view of container 300 according to another embodiment of the present invention, and it comprises container body 302, has the neck 304 of (optionally) screw thread 306, distribution tip part 308, the inner passage that narrows down gradually 314 and the expansion of leading to miniature fluid outlet 316 are held territory, liquid zone 318.The container 300 of Figure 11 is similar to the container 200 of Fig. 8, yet has some difference.First difference is to distribute the respective extension of outlet to hold the shape in territory, liquid zone around fluid.The embodiment that territory, liquid zone 318 is held in expansion among Figure 11 is shown as at vpg connection to crooked or hemispheric, and the expansion in the exemplary embodiment of Fig. 8, Fig. 9 and Figure 10 is held the shape in territory, liquid zone 218 and is shown as roughly foursquare or rectangle.Holding two kinds of shapes in territory, liquid zone and other shapes that those skilled in the art can conceive can both at least temporarily keep volume required contrast solution by capillary action, prepares contrast solution is dripped the sample receiving area that is applied to test-strips accuracy and the effect with the analyte test system of checking the user up to the user.
Be understood that, the shape of the distribution tip that Fig. 9, Figure 10 and Figure 11 provided is the exemplary suitable shape aspect volume and cross section, yet, those skilled in the art should be clear that, this volume can adopt any suitable 3D shape, for example sphere, elliposoidal, the parabolic bodily form, the cylinder bodily form, cone shape or the like, and this cross section can adopt any suitable two-dimensional shapes, for example rectangle, triangle, ellipse, quadrilateral (for example parallelogram), polygon (for example pentagon) or the like.
Second main difference between the container 300 of Figure 11 and the container 200 of Fig. 8 is the manufacturing of container alternatively.The distribution tip 208 of container 200 is shown as can molded separately member, it is made dividually with container body 202 and neck area 204 alternatively, yet distribution tip 308 zones of container 300 can be molded as integral member, promptly for example combine with container body 302 and neck area 304.Integrally molded container 300 has reduced the complicacy of container and has reduced manufacturing and packaging technology.Those skilled in the art should be clear that, can conceive the difference according to the manufacturing course of container of the present invention, and therefore are intended to it is included in herein.
Figure 12 is the low coverage cut-open view 400 that specialized designs becomes the exemplary embodiment of the cap 408 of cooperating mutually with the embodiment of fluid distribution tip 402 of the present invention, and it comprises fluid egress point 404, has diameter d 3With height h 3Expansion hold territory, liquid zone 406 and have corresponding degree of depth p 3The inner teat 410 of cap.
Figure 13 is the low coverage cut-open view 500 that specialized designs becomes another exemplary embodiment of the cap 508 of cooperating mutually with the embodiment of fluid distribution tip 502 of the present invention, and it comprises fluid egress point 504, has base diameter d 4With height h 4Taper shape expansion hold territory, liquid zone 506 and have corresponding degree of depth p 4The inner teat 510 of cap.
Figure 12 and Figure 13 show the exemplary embodiment according to distribution tip design of the present invention, it comprises complementary characteristic (being respectively part 410 and 510) at present in container cap, this complementary characteristic specialized designs becomes to be used for the seal tips opening and guarantees container fluid-tight and reliable storage is provided during transportation.In one embodiment, cap teat 410,510 can have yin-yang structure cooperation relation with distribution tip part 402,502 respectively so that reliable sealing to be provided.
Can find out that in Figure 12 and Figure 13 inner teat 410 and 510 specialized designs become to be used for receiving unit (being respectively that territory, liquid zone 406 and 506 is held in the expansion) interlocking with the distribution tip of cooperating.Expansion is held territory, liquid zone 406 and 506 and correspondingly be configured to receive teat 410,510 aspect size and dimension.The size and dimension that Figure 12 shows extended area 406 not only specialized designs becomes to be used to keep the contrast solution of suitable volumes to prepare it is applied to testing sensor up to the user, and additionally, in fact the device that the size and dimension of extended area 406 and inner teat 410 are cooperated mutually and guaranteed reliable and reliable sealing to provide has eliminated any contrast solution leaks out container when not using possibility thus.The degree of depth p of inner teat 3Hold the height h in territory, liquid zone 406 with expansion 3Cooperation, and hold the diameter d in territory, liquid zone 406 3Cooperate with the corresponding diameter of inner teat 410 equally.Therefore, when the container of contrast solution did not use, cap 408 can be fixed on the container body, contacted thereby mainly form with the distribution tip part 402 of container.Inner teat 410 closely is engaged in and holds in the territory, liquid zone 406, forms sealing reliably thus on fluid egress point 404.
Similarly, Figure 13 show conical inner teat 510 with the height h that holds territory, liquid zone 506 4Corresponding degree of depth p 4Therefore, when the user was attached to cap 508 on the container of contrast solution at distribution tip 502 places, teat 510 received and forms on fluid egress point 504 reliably and seal by holding territory, liquid zone 506.Figure 12 and Figure 13 show the container cap that comprises special seal feature design.
The present invention includes the device that is used to hold with dispense liquid solution.This liquid solution can be reagent, reactant or the contrast solution of any kind.Owing to can use a variety of liquid in various types of application and the environment, can exceed scope of the present invention with all possible liquid that system of the present invention together uses so enumerate.Yet native system can be used for need be frequently or do not use any application of potion liquid continually.In order to describe following this method, this liquid is the contrast solution that is used for the system of measuring physiological fluid sample analyte concentration is carried out Performance Evaluation.The example of this type of contrast solution is disclosed in U.S. Patent No. 5,187, and in 100 and No.5,605,837, these full patent texts are incorporated herein.
The present invention can provide lot of advantages, comprise control more easily volume of sample and thereby control applying of sample more easily, thereby make the user more confident to the control solution test program.In addition, the target of distribution tip of the present invention is to minimize overflowing of any sample or the migration of fluid on the distribution tip sidepiece by only providing near volume required contrast solution volume.In addition, fluid volume at least temporarily remains in the extended area of distribution tip partly, so that assist in ensuring that enough volume of sample when implementing control solution test.
The exemplary embodiment of the fluid distribution tip that provides herein helps the user sample is guided on the sample receiving area of testing sensor.Sample through improving applies and has in fact also eliminated the needs that the cleaning anything unexpected overflows.Fluid distribution tip of the present invention also reduces the requirement to the nimble property of user, makes that the control solution test program is easier.In addition, the cap designs of cooperation guarantees that container keeps fluid-tight when not using and between transportation and storage life.
The container of control solution that comprises distribution tip of the present invention also can reduce the pollution risk of untapped contrast solution, and this provides a kind of more reliable measuring system again, and can be by maximization pot-life and additionally cost is effective more to the user.Contaminated contrast solution can produce inaccurate result, and should be dropped.

Claims (6)

1. fluid dispenser container, it comprises:
Deformable container body, it has distribution tip and is used to hold the hollow inside for the treatment of from the liquid of described distribution tip distribution;
The inner passage of convergent shape, it leads to outlet to allow drop by described outlet;
Around the hydraulic accumulator of described outlet, described hydraulic accumulator is set to keep the liquid volume of being scheduled to aspect size.
2. fluid dispenser container as claimed in claim 1 is characterized in that, the described territory, liquid zone of holding has the diameter and the degree of depth in the scope of about 0.1mm to 5.0mm in the scope of about 1.0mm to 10.0mm.
3. fluid dispenser container as claimed in claim 1 is characterized in that, the described territory, liquid zone of holding has the diameter and the degree of depth in the scope of about 1.0mm to 2.0mm in the scope of about 2.0mm to 4.0mm.
4. fluid dispenser container as claimed in claim 1 is characterized in that, described predetermined liquid volume is in the scope of about 100nL to 200 μ L.
5. fluid dispenser container as claimed in claim 1 is characterized in that, described predetermined liquid volume is in the scope of about 1 μ L to 20 μ L.
6. fluid dispenser container as claimed in claim 1 is characterized in that, described hydraulic accumulator can be removed from described container body.
CNA200810172994XA 2007-10-19 2008-10-20 Liquid dispensing tip with reservoir Pending CN101430337A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98133007P 2007-10-19 2007-10-19
US60/981330 2007-10-19

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CN101430337A true CN101430337A (en) 2009-05-13

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CNA200810172994XA Pending CN101430337A (en) 2007-10-19 2008-10-20 Liquid dispensing tip with reservoir

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US (1) US20090101681A1 (en)
EP (2) EP2214831A1 (en)
JP (2) JP2009102070A (en)
KR (1) KR20100085111A (en)
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EP2050501A1 (en) 2009-04-22
JP2009102070A (en) 2009-05-14
CN101903106A (en) 2010-12-01
US20090101681A1 (en) 2009-04-23
JP2011501722A (en) 2011-01-13
EP2214831A1 (en) 2010-08-11
KR20100085111A (en) 2010-07-28
WO2009052243A1 (en) 2009-04-23

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