CN101422589A - Compound preparation capable of invigorating the brain and promoting intelligenc - Google Patents
Compound preparation capable of invigorating the brain and promoting intelligenc Download PDFInfo
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- CN101422589A CN101422589A CNA200810176646XA CN200810176646A CN101422589A CN 101422589 A CN101422589 A CN 101422589A CN A200810176646X A CNA200810176646X A CN A200810176646XA CN 200810176646 A CN200810176646 A CN 200810176646A CN 101422589 A CN101422589 A CN 101422589A
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- fructus alpiniae
- alpiniae oxyphyllae
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Abstract
The invention discloses a traditional Chinese medicine compound preparation used for nourishing the brain and improving intelligence, which is characterized in that the preparation is prepared by radix astragali and fructus alpiniae oxyphyllae. The invention selects the composed prescription of two medicaments, uses fructus alpiniae oxyphyllae for reinforcing kidney and strengthening brain and sustaining congenital essential substance and radix astragali for nourishing spleen-qi and activating acquired constitution. The combination of the two medicaments can reinforce spleen and kidney together and give attention to both innateness and postnatal, thereby achieving the purposes of reinforcing spleen and kidney, increasing wisdom and improving hearing and vision. The Chinese herbal medicine compound preparation is simple in composition and significant in effect, and the quality is easy to control.
Description
Technical field
The invention belongs to the field of Chinese medicines, relate to a kind of Chinese medicine composition and process for producing thereof that is used for the treatment of brain disorder, relate in particular to a kind of nourishing the brain and improving intelligence Chinese medicine compound combination, medicine is made of according to a certain percentage Fructus Alpiniae Oxyphyllae and the Radix Astragali two flavor Chinese medicines, is used for the treatment of brain disorders such as neurasthenia, hypomnesis, alzheimer disease and apoplexy sequela.
Background technology
The epizootic disease research, whole world brain diseases patient, along with the aging day by day of the age structure of population, its sick M ﹠ M has and significantly increases trend, and all with sequela; In recent years because factors such as weather, environment and life stresss, the sickness rate of encephalopathy is also constantly increasing, its age of onset also tends to rejuvenation day by day, some are also in rising trend day by day as brain disorders such as neurasthenia, hypomnesis, alzheimer disease and apoplexy sequela, have become to threaten human life and the great illness of quality of life.
Nourishing the brain and improving intelligence class Chinese medicine occupies the market share of considerable part in the market, and great majority are the big compound preparation of Chinese medicine, and essential drugs is formed many between 10～18 flavors, these class prescription flavour of a drug are numerous, complicated component is so difficult quality control easily causes untoward reaction.
The zingiberaceous plant Fructus Alpiniae Oxyphyllae is one of Hainan Si Danan medicine, mainly is distributed in the various places counties and districts in Hainan, in addition, also there are a large amount of cultivations on ground such as Guangxi, Guangdong, especially occupy first of the output of four Da Nan medicines in its Fructus Alpiniae Oxyphyllae resource of Hainan, reserves are very abundant, possess the medicine resource of a large amount of exploitations.It is puckery through taking the photograph the effect of saliva, warming and recuperating the kidney-YANG, warming the lung, Fructus Alpiniae Oxyphyllae replenishing essence that it has a controlling nocturnal emission with astringent drugs, can be rated as the kidney invigorating health care good medicine.
The leguminous plant Radix Astragali also is large northern medical material, and its cultivation technique is relatively low, is fit to plantation in all parts of the country, market at home at present, and the area of its plantation is quite extensive.Have tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, the effect of holder skin ulcer granulation promoting has from its functional component, mainly is polysaccharide and saponin component, and human body immunity improving is arranged, and strengthens the effect of neuroprotective, is the good merchantable brand of invigorating the spleen and replenishing QI.
But, yet there are no the report and the application that the compound preparation of the Radix Astragali and Fructus Alpiniae Oxyphyllae composition are used for the treatment of brain disorders such as neurasthenia, hypomnesis, alzheimer disease and apoplexy sequela.
Summary of the invention
The object of the present invention is to provide a kind of nourishing the brain and improving intelligence compound Chinese medicinal preparation, to be used for the treatment of brain disorders such as neurasthenia, hypomnesis, alzheimer disease and apoplexy sequela.
Nourishing the brain and improving intelligence compound Chinese medicinal preparation of the present invention is to be made by the Radix Astragali and two kinds of raw material of Chinese medicine of Fructus Alpiniae Oxyphyllae.
The weight proportion of the described Radix Astragali and Fructus Alpiniae Oxyphyllae is 1:0.5～2, is preferably 1:2.
The oral effective daily dose of the present invention is 10～100g raw medicinal herbs, 2～3 times on the one.
The present invention also provides the preparation method of above-mentioned nourishing the brain and improving intelligence compound Chinese medicinal preparation: take by weighing the raw material of Chinese medicine medicine Fructus Alpiniae Oxyphyllae and the Radix Astragali, pulverize, adding 4～20 times of amounts of water soaked 0.5～2.0 hour, decocted 0.5～10 hour, and decocted number of times 1～3 time, then decoction liquor is filtered, be concentrated into relative density 0.5～2.0, spray drying gets dry extract, makes the dosage form of accepting on the pharmaceutics to wherein adding adjuvant again.
Also can adopt following method to extract preparation: to take by weighing the raw material of Chinese medicine medicine Fructus Alpiniae Oxyphyllae and the Radix Astragali, pulverize, extract 1～10 time through adding 4～20 times of amounts of 5%～95% (v/v) ethanol, with extracting liquid filtering, reclaim ethanol, filtrate is concentrated into relative density 0.5～2.0, spray drying, get dry extract, make the dosage form of accepting on the pharmaceutics to wherein adding adjuvant again.
Can also prepare with following method: take by weighing the raw material of Chinese medicine medicine Fructus Alpiniae Oxyphyllae and the Radix Astragali, pulverize, water or soak with ethanol, adopt ultrasonic extraction then, extract 1～10 time, extracting liquid filtering, be concentrated into relative density 0.5～2.0, spray drying gets dry extract, makes the dosage form of accepting on the pharmaceutics to wherein adding adjuvant again.
Ultrasonic extraction can adopt following condition: 0.5～10 hour time, frequency 10Hz～1000kHz, power 10w～5000kw.
The present invention selects the two medicine sides of being combined into for use, with the Fructus Alpiniae Oxyphyllae kidney-tonifying and brain tonic, takes a tonic or nourishing food to build up one's health the congenital foundation; With Radix Astragali invigorating the spleen and replenishing QI, the foundation of acquired constitution is mended in training, and two medicines share, reinforce spleen and kidney together, and elder generation will take into account the day after tomorrow altogether, thereby reach the spleen reinforcing kidney, increase wisdom, the effect of audition improvement tomorrow.Prescription of the present invention is simple, and drug effect is remarkable, and quality is easy to control.Effect with tonic spleen kidney, nourishing the brain and improving intelligence, can effectively treat diseases such as neurasthenia, hypomnesis, alzheimer disease and apoplexy sequela, it has treatment and health care double effects, not only is adapted to the old man but also be adapted to young student, the crowd of being suitable for is extensive, and safety coefficient is quite high.
Description of drawings
Fig. 1 is that the experimental mouse brain hippocampus of experimental example 1 empty group tectology changes, HE dyeing * 100.
Fig. 2 is that the experimental mouse brain hippocampus of model group tectology changes in the experimental example 1, HE dyeing * 100.
The specific embodiment
The invention will be further described below in conjunction with specific embodiment, to help understanding content of the present invention.
Embodiment 1
Take by weighing 2 parts of raw material of Chinese medicine medicine Fructus Alpiniae Oxyphyllae, 1 part of the Radix Astragali, pulverize, add 4～20 times of amounts of water and soaked 0.5～2.0 hour, decocted 0.5～10 hour, decoct number of times 1～3 time, merge decoction liquor then, filter, be concentrated into relative density 0.5～2.0, spray drying gets dry extract.Again to wherein adding an amount of supplementary product starch, lactose, sodium carboxymethyl cellulose, and an amount of crospolyvinylpyrrolidone, magnesium stearate etc., by suitable preparation means, as mixing, granulation, granulate, tabletting, finished product.
Embodiment 2
Take by weighing 2 parts of raw material of Chinese medicine medicine Fructus Alpiniae Oxyphyllae, 1 part of the Radix Astragali, suitably pulverize, through adding 4～20 times of amounts of 5%～95% ethanol (v/v), extraction time 1～10 time, merge extractive liquid, filters then, reclaims ethanol, filtrate is concentrated into relative density 0.5～2.0, and spray drying gets dry extract.Again to wherein adding an amount of supplementary product starch, lactose, sodium carboxymethyl cellulose, and an amount of crospolyvinylpyrrolidone, magnesium stearate etc., by suitable preparation means, as mixing, granulation, granulate, tabletting, finished product.
Embodiment 3
Take by weighing 1 part of raw material of Chinese medicine medicine Fructus Alpiniae Oxyphyllae, 1 part of the Radix Astragali, suitably pulverize, soak in order to water (or ethanol), adopt ultrasonic extraction, 0.5～10 hour time, frequency 10Hz～1000kHz, power 10w～5000kw, extraction time 1～10 time, merge extractive liquid, filters then, is concentrated into relative density 0.5～2.0, spray drying gets dry extract.Again to wherein adding an amount of supplementary product starch, lactose, sodium carboxymethyl cellulose, and an amount of crospolyvinylpyrrolidone, magnesium stearate etc., by suitable preparation means, as mixing, granulation, granulate, tabletting, finished product.
The beneficial stilbene extractum of experimental example 1 different proportionings is to the influence of experimental senile dementia model mice memory ability and cerebral hippocampus district SOD content
1 laboratory animal
Select 80 of health Kunming mouses in 4～6 age in week for use, male and female half and half, body weight 24～26g purchases the Experimental Animal Center in Chengdu University of Traditional Chinese Medicine.The free diet drinking-water of whole experiment mice, in 24 ± 2 ℃ of room temperatures, 12h illumination, the 12h dark condition is raised down.
2 experimental apparatus and reagent
Ultraviolet spectrophotometer (production of Shanghai the 3rd analytical tool factory), Y labyrinth-case (the neural biological center of Xiangya Medical College, Zhongnan Univ provides); Benefit stilbene extractum I (Fructus Alpiniae Oxyphyllae: the Radix Astragali=1:1), beneficial stilbene extractum II (Fructus Alpiniae Oxyphyllae: the Radix Astragali=2:1) (Hainan full star Pharmaceutical academy preparation); D-galactose (Shanghai permanent letter chemical reagent company limited, lot number: 20060221); Piracetam (Anhui Ji Ren pharmaceutcal corporation, Ltd, lot number: 071002); SOD testing cassete and Coomassie brilliant blue protein determination kit (bio-engineering research institute product is built up in Nanjing).4% formaldehyde fixed liquid.
3 methods
3.1 animal grouping and administration
Mice conforms two days later, and the table of random number method is divided into 5 groups: matched group (10), model group (10), piracetam group (10), beneficial stilbene increase intelligence sheet low dose group (10) and beneficial stilbene increases intelligence sheet high dose group (10), every group of male and female half and half.The matched group subcutaneous injection is also irritated stomach normal saline (0.3ml/d); Model group subcutaneous injection D-galactose (50mg/kg.d) is also irritated stomach normal saline (0.3ml/d); Positive controls subcutaneous injection D-galactose (50mg/kg.d) is also irritated stomach piracetam (180mg/kg.d); The benefit stilbene increase intelligence sheet low dose group and beneficial stilbene increase intelligence sheet high dose group subcutaneous injection D-galactose (50mg/kg.d) and irritate stomach benefit stilbene increase the intelligence sheet (120mg/kg, 240mg/kg).D-galactose subcutaneous injection continued for 6 weeks, and meanwhile beneficial stilbene increases the intelligence sheet and irritates the also lasting identical all numbers of stomach.
3.2 Y labyrinth-case learning and memory performance testing
Behavioral experiment carries out in 3 equal portions radiant type labyrinths.The display lamp of a 15W all is equipped with on the top of each wall of labyrinth, is parallel alternate copper rod at the bottom of the wall.The bright wall of lamp is the place of safety, energising at the bottom of all the other two dark walls.Directly run to the place of safety as animal by initial wall, be correct response.Every animal is trained 20 times every day, trains 7d continuously, reaches 90% standard as association with the correct response rate, to reach the index of the required frequency of training of association's standard as school grade, carries out statistical procedures.
3.3 cerebral hippocampus district SOD and brain determining the protein quantity
Assay method is undertaken by description separately respectively.
4 statistical procedures
Use SPSS 10.0 softwares and carry out statistical procedures.Data are represented with ± S, relatively adopt the t check between group, and P＜0.05 expression has significant difference.
5 results
5.1 beneficial stilbene increases the intelligence sheet is induced the senile dementia ability of learning and memory in mice to the D-galactose influence
Behavioral experiment shows (as table 1), model group mice required frequency of training up to standard is apparently higher than matched group (p＜0.01), the benefit stilbene increases that the intelligence sheet is low, high dose group required frequency of training up to standard significantly is lower than model group (p＜0.01), but more not remarkable than difference with matched group and positive controls.Illustrate that beneficial stilbene increases the intelligence sheet and can significantly improve the senile dementia learning and memory abilities in aging mice.
The beneficial stilbene of table 1 increase the intelligence sheet to the influence of senile dementia ability of learning and memory in mice, Hippocampus SOD vigor and hippocampal protein content (± S)
Annotate: with matched group ratio, ☆ P＜0.05, ☆ ☆ P＜0.01; With the model group ratio,
*P＜0.05,
*P＜0.01.
5.2 beneficial stilbene increases the influence of intelligence sheet water extract to senile dementia mice Hippocampus SOD vigor and hippocampal protein content
Table 1 shows that model group Hippocampus SOD vigor significantly is lower than matched group (p＜0.05); Benefit stilbene extractum I, II group Hippocampus SOD vigor are significantly higher than model group (p＜0.05), but with matched group and positive controls than no significant difference.Model group mice hippocampal protein content significantly is lower than matched group (p＜0.01); Benefit stilbene extractum I, II group mice hippocampal protein content are significantly higher than model group (p＜0.01), and more not remarkable than difference with matched group, and the effect of the raising Hippocampus SOD vigor of beneficial stilbene extractum I and protein content is obvious not as good as beneficial stilbene extractum II.
5.3 pathological study
Get a little cerebral tissue and fix with 4% formaldehyde fixed liquid, conventional dehydration, transparent, paraffin embedding is got the conventional 4 μ m continuous coronal section of dorsal part Hippocampus.Carry out HE dyeing, light microscopic is observed the hippocampus tectology down and is changed.
As shown in Figure 1, the HE demonstration of dyeing, blank group hippocampus pyramidal cell nuclear is big and justify, and kernel is obvious, the projection of visible understain, cell is arranged closely neatly, visible 2～3 layers of pyramidal cell; As shown in Figure 2, model group hippocampus pyramidal cell is sparse, loose, lacks unity and coherence, the other free district of dying of the cell that has, and visible karyopycnosis, kytoplasm is dense to be dyed, the cell that cell space diminishes; The cell level is unclear.
6. experiment conclusion:
Observed of the influence of the beneficial stilbene extractum of different pharmaceutical proportioning by experiment to the inductive hypomnesis model mice of D-galactose ability of learning and memory, reach influence to mice Hippocampus SOD vigor and hippocampal protein content, the result shows that beneficial stilbene extractum can significantly improve the inductive ability of learning and memory in mice of D-galactose and go down, and the raising Hippocampus SOD vigor of beneficial stilbene extractum I and the effect of protein content are obvious not as good as beneficial stilbene extractum II, promptly with 2 parts of Fructus Alpiniae Oxyphyllae, the beneficial stilbene extractum of 1 part of composition of the Radix Astragali can improve Hippocampus SOD vigor and Hippocampus brain protein content effectively.This explanation is with 2 parts of Fructus Alpiniae Oxyphyllae, and the beneficial stilbene extractum of 1 part of composition of the Radix Astragali has memory reinforcing, improves brain SOD contents level, the effect of auxiliary alzheimer disease.
Claims (7)
1, a kind of nourishing the brain and improving intelligence compound Chinese medicinal preparation is characterized in that it being to be made by the Radix Astragali and two kinds of raw material of Chinese medicine of Fructus Alpiniae Oxyphyllae.
2, nourishing the brain and improving intelligence compound Chinese medicinal preparation as claimed in claim 1, the weight proportion that it is characterized in that the described Radix Astragali and Fructus Alpiniae Oxyphyllae is 1:0.5～2.
3, nourishing the brain and improving intelligence compound Chinese medicinal preparation as claimed in claim 1, the weight proportion that it is characterized in that the described Radix Astragali and Fructus Alpiniae Oxyphyllae is 1:2.
4, the preparation method of described nourishing the brain and improving intelligence compound Chinese medicinal preparation one of in a kind of claim 1 to 3, it is characterized in that this method is: take by weighing the raw material of Chinese medicine medicine Fructus Alpiniae Oxyphyllae and the Radix Astragali, pulverize, add 4～20 times of amounts of water and soaked 0.5～2.0 hour, decocted 0.5～10 hour, decoct number of times 1～3 time, then decoction liquor is filtered, be concentrated into relative density 0.5～2.0, spray drying, get dry extract, make the dosage form of accepting on the pharmaceutics to wherein adding adjuvant again.
5, the preparation method of described nourishing the brain and improving intelligence compound Chinese medicinal preparation one of in a kind of claim 1 to 3, it is characterized in that this method is: take by weighing the raw material of Chinese medicine medicine Fructus Alpiniae Oxyphyllae and the Radix Astragali, pulverize, extract 1～10 time through adding 4～20 times of amounts of volumn concentration 5%～95% ethanol,, reclaim ethanol extracting liquid filtering, filtrate is concentrated into relative density 0.5～2.0, spray drying gets dry extract, makes the dosage form of accepting on the pharmaceutics to wherein adding adjuvant again.
6, the preparation method of described nourishing the brain and improving intelligence compound Chinese medicinal preparation one of in a kind of claim 1 to 3, it is characterized in that this method is: take by weighing the raw material of Chinese medicine medicine Fructus Alpiniae Oxyphyllae and the Radix Astragali, pulverize, water or soak with ethanol adopt ultrasonic extraction then, extract 1～10 time, with extracting liquid filtering, be concentrated into relative density 0.5～2.0, spray drying, get dry extract, make the dosage form of accepting on the pharmaceutics to wherein adding adjuvant again.
7, preparation method as claimed in claim 6 is characterized in that: described ultrasonic extraction adopts following condition: 0.5～10 hour time, frequency 10Hz～1000kHz, power 10w～5000kw.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106266898A (en) * | 2016-09-27 | 2017-01-04 | 杭州本草养正堂生物科技有限公司 | A kind of vital energy benefiting and the kidney invigorating, the compound preparation and preparation method thereof of defying age |
| CN106581400A (en) * | 2017-01-12 | 2017-04-26 | 喻鸿章 | Traditional Chinese medicine capable of tonifying kidney, benefiting qi, tonifying brain and developing intelligence and preparation method for capsule of same |
| CN108882744A (en) * | 2016-04-08 | 2018-11-23 | 韩国韩医学研究院 | Contain intelligence development extract as effective component for preventing, improving or treating the composition of hyperuricemia or dysbolism relevant to hyperuricemia |
-
2008
- 2008-11-13 CN CNA200810176646XA patent/CN101422589A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108882744A (en) * | 2016-04-08 | 2018-11-23 | 韩国韩医学研究院 | Contain intelligence development extract as effective component for preventing, improving or treating the composition of hyperuricemia or dysbolism relevant to hyperuricemia |
| CN106266898A (en) * | 2016-09-27 | 2017-01-04 | 杭州本草养正堂生物科技有限公司 | A kind of vital energy benefiting and the kidney invigorating, the compound preparation and preparation method thereof of defying age |
| CN106581400A (en) * | 2017-01-12 | 2017-04-26 | 喻鸿章 | Traditional Chinese medicine capable of tonifying kidney, benefiting qi, tonifying brain and developing intelligence and preparation method for capsule of same |
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Open date: 20090506 |