CN101422549B - Traditional Chinese medicine external preparation capable of improving ascites due to cirrhosis and preparation method thereof - Google Patents
Traditional Chinese medicine external preparation capable of improving ascites due to cirrhosis and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the field of traditional Chinese medicine preparation, in particular to a traditional Chinese medicine external preparation used for improving ascites due to cirrhosis and the preparation method. Based on the former experience and combined with the new related progress in the technique, the invention adopts the Chinese bulk drugs including fresh milk veteh, accessory piece, cinnamon, rhizoma cyperi, clove, borneol and muskiness, or adopts fresh rhubarb, radish seed, euphorbia kansui, tambac, clove, borneol and muskiness, thus preparing asthenia distension external used preparation for treating ascites due to cirrhosis (extracting cataplasm). The traditional Chinese medicine preparation carries out clinical experimental therapy according to clinical deficiency syndrome and demonstration syndrome; as result showing, the preparation has functions of improving abdominal distension, whetting the appetite and promoting ascites to fade, thereby being capable of treating ascites due to cirrhosis.
Description
The application is a denomination of invention: improve the Chinese medicine for external application and the preparation method of cirrhotic ascites,
Application number: 200510028971.8, the applying date: the division on August 19th, 2005.
Technical field:
The invention belongs to field of traditional Chinese.Be specifically related to improve the Chinese medicine for external application and the preparation method of cirrhotic ascites.
Background technology:
Liver cirrhosis is the pathological changes in whole latter stage of chronic hepatic diseases, is to cause human dead important diseases, serious harm human health.Its cause of disease has multiple, comprises hepatitis virus, schistosomicide, medicine, ethanol and chemical poisoning etc.Ascites is the common complication of liver cirrhosis, loses the compensatory stage in liver function, often causes patient's ascites because of portal venous pressure rising, plasma albumin reduction, infection and endotoxemia etc., has a strong impact on patient's health and daily life quality.Therefore, actively prevent and treat ascites, alleviate symptoms such as abdominal distention, improving liver cirrhosis patient quality of life, promoting that patient's rehabilitation is significant.
At present, cirrhotic ascites Therapeutic Method commonly used clinically has Drug therapy and non-medication Therapeutic Method.Drug treatment commonly used comprises: use diuretic, albumin or antibiotic etc., but there are problems such as electrolyte disturbance or expense costliness in these methods in treatment, and relatively poor to the difficultly curing ascites effect; The non-medication method is put ascites, ascites as puncture and is concentrated vein feedback etc., and difficultly curing ascites is had very fast and effect preferably, but causes that easily infection, electrolyte disturbance or circulatory function are unusual etc., and needs certain facility, and it is very not convenient to use.Therefore, cirrhotic ascites is still clinical refractory disease at present.
Cirrhotic ascites belongs to Chinese medicine " tympanites " category, and Chinese medicine has abundant theory and practice experience in its treatment, and compound decoction is oral to be common method.But cirrhotic ascites patient is because of abdominal distension, stomach volume reducing often, and feed (comprising the oral Chinese medicine decoction) is difficulty comparatively.External treatment rules such as medicament plaster can overcome these drawbacks, and avoid part patient hemorrhage etc. the danger of breaking because of esophageal varix, tablet stimulate.
It is one of external treatment of showing unique characteristics of Chinese medicine that medicine applies umbilicus, the record of promptly pasting medicine as far back as period in Spring and Autumn and Warring States's " 52 Bingfang " relevant for umbilicus; To the Ming Dynasty, Li Shizhen (1518-1593 A.D.) Compendium of Material Medica record: " (Radix Phytolaccae) controls generalized edema with distention of the chest and abdomen, dysuria person, mashes with red, goes into Moschus three minutes, is affixed on the acromphalus, restraints it with silks, normal urination is promptly swollen disappear ".To the Qing Dynasty, external treatment expert Wu Shiji upright " ten distensions water intaking cream " etc. relieve oedema or abdominal distension through diuresis or purgation with external application, still are used for the intractable cirrhotic ascites so far, and this shows that cirrhotic ascites applying Chinese medicine to the umbilicus therapy is of long standing and well established, and have " letter, just, test, honest and clean " characteristics.
The theoretical basis of applying Chinese medicine to the umbilicus is theory of channels and collaterals, the Pathophysiology characteristics of dermovascular tissue characteristic of umbilical part and liver cirrhosis.Umbilicus is a SHENJUE acupoint, has another name called " gas meeting ", belongs to conception vessel, and inside and outside linking up by meridians, the network whole body plays an important role in meridian qi and blood operation and function are regulated.The horny layer of epidermis of umbilical part skin is poor, subcutaneous fat-free mass, and abundant vessel branch is arranged on every side, and these characteristics are beneficial to the Transdermal absorption of medicine.And during liver cirrhosis, the portal vein increased pressure is arranged more, and collateral circulation forms with open, and one of them is to form passage between vena epigastrica and liver postcava.This pathophysiological change more helps cover-navel medicine and enters blood by this collateral circulation and play a role.Therefore medicine applies umbilicus on the one hand by the stimulation of medicine to local teleneuron, promotes enterokinesia, promotes exhaust defecation and diuresis.On the other hand, medicine passes through to influence SHENQUE acupoint, and dredging the meridian promotes QI-blood circulation, regulates function; And, enter body blood by Transdermal absorption, and reach disease institute, thus the effect of performance wholistic therapy.
Applying Chinese medicine to the umbilicus treatment cirrhotic ascites has more report in recent years, though medicament composing prescription differs, all obtains certain curative effect.As Jiang Chunhua Radix Kansui, Natrii Sulfas; Xia Dexin Radix Kansui, Cortex Cinnamomi, Herba Plantaginis; Lei Ling has certain curative effect with deposited umbilicuss such as Radix Kansui, Semen Pharbitidis, Radix Stephaniae Tetrandrae, Lignum Aquilariae Resinatum.Confirm that this method has important value and bright prospects in the Comprehensive Treatment of cirrhotic ascites.
But practice finds to remain the problem that need solve or further inquire at some.One, above-mentioned compound recipe are to it " disease " in disease or the disease mostly, rather than to " card ".And dialectical opinion to control be the marrow of Chinese medicine, Chinese medicine compound is the treatment by oral administration of medicines external treatment no matter, all should determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs.Its two, standard is owed in clinical design, own control before and after mostly being lacks at random the research with the double blind control method, the clinical research of strictly regulating has to be strengthened.Its three, preparation is extensive, is that Chinese medicine is rough for powder mostly, is adjusted to pasty state with water or vinegar.It is very not convenient to make this Chinese medicine preparation use, and deficient in stability is in less considerations in aspect such as drug transdermal absorption and external application moisture retention performances.Its four, Moschus is widely used in deposited Qizhong, acts on importantly, but mostly is natural product, this animal Moschus moschiferous and natural Moschus's resource scarcity thereof at present, thereby need to consider that using artificial Moschus (first class national new drug) replace.Though applying Chinese medicine to the umbilicus treatment cirrhotic ascites is with a long history, be widely used, the characteristic distinctness does not still have the new Chinese medicine of exterior-applied formulation so far.
Summary of the invention:
The objective of the invention is deficiency and defective, a kind of Chinese medicine for outer use that improves cirrhotic ascites is provided for overcoming prior art.Another object of the present invention provides the preparation method of described preparation.
The present invention is according to the past experience, and in conjunction with related developments recently, preparation is used for excess distension side's external preparation of cirrhotic ascites excess syndrome and is used for deficiency-distension side's external preparation of cirrhotic ascites excess syndrome.Adopt the Chinese medicine Radix Astragali, RADIX ACONITI LATERALIS PREPARATA, Cortex Cinnamomi, Rhizoma Cyperi, Flos Caryophylli, Borneolum Syntheticum and Moschus prepare Chinese medicine for external application (extraction cataplasma), or adopt Chinese medicine Radix Et Rhizoma Rhei, Semen Raphani, Radix Kansui, Lignum Aquilariae Resinatum, Flos Caryophylli, Borneolum Syntheticum and Moschus are made above-mentioned Chinese medicine for external application (extraction cataplasma).The present invention is directed to patient's clinical symptoms, district's component layers is deficiency syndrome and excess syndrome, is divided into treatment group and matched group at random, carries out the clinical experiment treatment.The result shows, this preparation has and improves the effect that patient's abdominal distention, appetite strengthening and promotion ascites disappear, and can be used for the treatment of cirrhotic ascites.
The specific embodiment
Embodiment 1 preparation Chinese medicine for external application of the present invention
One, the deficiency-distension side that is used for the cirrhotic ascites deficiency syndrome
1. adopt the Chinese medicine Radix Astragali, RADIX ACONITI LATERALIS PREPARATA, Cortex Cinnamomi, Rhizoma Cyperi, Flos Caryophylli, Borneolum Syntheticum and Moschus, the preparation deficiency syndrome are with extracting cataplasma.Described medicine activity component weight proportion such as following:
Radix Astragali 20-500g RADIX ACONITI LATERALIS PREPARATA 20-500g
Cortex Cinnamomi 20-500g Rhizoma Cyperi 20-500g
Flos Caryophylli 20-500g Borneolum Syntheticum 4-100g Moschus 200-500mg (natural or artificial Moschus)
Above-mentioned prescription medical material amounts to 104.2-2600.5g, and average out to 580g makes cataplasma 20 and pastes.
Get Radix Astragali, RADIX ACONITI LATERALIS PREPARATA, Cortex Cinnamomi, Rhizoma Cyperi 4 flavor medicines altogether 400g decoct with water 2 times, 8 times of water gagings decocted 2 hours for the first time; 6 times of water gagings decocted 1 hour for the second time, merged filtrate twice, were condensed into extractum, relative density 1.35-1.45.The Borneolum Syntheticum porphyrize is crossed 60 mesh sieves, adds extractum and mixes thoroughly.Flos Caryophylli is extracted Flos Caryophylli volatile oil with steam distillation, volatile oil 5-8ml is added in the extractum mix thoroughly.Moschus grinds well porphyrize with low amounts of water, adds extractum and mixes thoroughly.
Flos Caryophylli adopts steam distillation to extract Flos Caryophylli volatile oil in the above-mentioned prescription, just adds 5 times of water gagings surely, soaks 30min, and straight fire extracts 5-6h.All the other medical materials extract with traditional decocting method.Borneolum Syntheticum is volatile, so porphyrize adds extractum after crossing 60 mesh sieves.
Wherein the Cortex Cinnamomi medical material directly adds decocting and boils water yield 6-8 times of water gaging.
2. substrate preparation
Glycerol 20-40g NP-700 or NP600 2-5g tartaric acid 0.1-0.3g
Distilled water 50-70ml aluminium hydroxide 0.2-0.5g
Above-mentioned prescription is the 100g scale.
Wherein, NP-700 or NP600: the polyacrylic acid that part is neutralized is the straight key copolymer of acrylic acid and sodium acrylate; Glycerol: wetting agent; Aluminium hydroxide: cross-linking agent, crosslinked with NP-700; Tartaric acid: dissolving Al
3+Chemical compound
1. the aluminium hydroxide adding is filled in the 200ml beaker of glycerol, fully mix, add NP-700 and continue again to mix.
2. tartaric acid is placed the 100ml beaker, add the 60ml dissolved in distilled water.
3. get equal portions 5ml tartaric acid solution respectively, add in the above-mentioned 200ml beaker, add abundant mixing at every turn.
4. after all equal portions add, continue to stir 20 minutes.
3. medicine mixes with substrate
Substrate is added in the extractum, fully coat behind the mixing on the non-woven fabrics promptly.
Above-mentioned cataplasma can be used for treating the deficiency-distension that hepatic ascites causes, has following tangible advantage: 1. compare with oral formulations, no liver first-pass effect is not subjected to factor affecting such as gastric emptying rate, the bioavailability height; 2. no pain easy to use; 3. compare with ointment, dosage is accurate, and absorption area is fixed, and it is stable to learn concentration.
Two, the excess distension side that is used for the cirrhotic ascites excess syndrome
1, adopt Radix Et Rhizoma Rhei, Semen Raphani, Radix Kansui, Lignum Aquilariae Resinatum, Flos Caryophylli, Borneolum Syntheticum and Moschus to prepare excess syndrome with extracting cataplasma.Described medicine activity component weight proportion such as following:
Radix Et Rhizoma Rhei 20-500g Semen Raphani 20-500g
Radix Kansui 20-500g Lignum Aquilariae Resinatum 20-500g
Flos Caryophylli 20-500g Borneolum Syntheticum 4-100g Moschus 20-500mg (natural or artificial)
Above-mentioned prescription medical material amounts to 500g, makes cataplasma 20 and pastes.
Get Radix Et Rhizoma Rhei, Semen Raphani, Radix Kansui, Lignum Aquilariae Resinatum 4 flavor medicines 320g altogether, decoct with water 2 times, 8 times of water gagings decocted 2 hours for the first time; 6 times of water gagings decocted 1 hour for the second time, merged filtrate twice, were condensed into extractum.The Borneolum Syntheticum porphyrize is crossed 60 mesh sieves, adds extractum and mixes thoroughly.Flos Caryophylli is extracted Flos Caryophylli volatile oil with steam distillation, volatile oil is added in the extractum mix thoroughly.Moschus grinds well porphyrize with low amounts of water, adds extractum and mixes thoroughly.Wherein, Flos Caryophylli adopts steam distillation to extract Flos Caryophylli volatile oil, just adds 5 times of water gagings surely, soaks 30min, and straight fire extracts 5-6h.All the other medical materials extract with traditional decocting method.Borneolum Syntheticum is volatile, so porphyrize adds extractum after crossing 60 mesh sieves.
According to prescription preparation sample, Semen Raphani wherein, Lignum Aquilariae Resinatum all are ground into powder, and Semen Raphani adds decoction, and Lignum Aquilariae Resinatum then back adds in the extractum; Or directly Semen Raphani, Lignum Aquilariae Resinatum are added decoction.Amount of water is 6 times of water gagings, or the head fry in shallow oil 8 times of water gagings, two fry in shallow oil 6 times of water gagings.
Other technological processes, substrate and preparations shaping are the same.
The clinical efficacy of embodiment 2 excess distension sides and deficiency-distension side's cataplasma auxiliary treatment cirrhotic ascites excess syndrome and deficiency syndrome
Preparation of the present invention is through Study on clinical pharmacodynamics, and the result shows to have the new purposes that can improve cirrhotic ascites.
Diagnostic criteria
Doctor trained in Western medicine standard: meet the diagnostic criteria [1] of the whole nation, Xi'an in 2000 hepatitis hepatopathy association view: a) lose compensatory liver cirrhosis (Child-Pugh classification B/C level).B) obvious abnormal liver function and lose compensatory sign is arranged, as serum albumin＜35g/L, A/G＜1.0; Or obvious jaundice, bilirubin〉35 μ mol/L; Or ALT and AST rising; Or thrombinogen mobility＜60%.Ascites appears in the patient.C) imaging diagnosis, B ultrasonic see that liver dwindles, and the liver surface is obviously uneven, zigzag or wavy, liver edge rust, liver parenchyma echo inequality, enhancing are nodositas, portal vein and the broadening of hilus lienis vein internal diameter, hepatic vein attenuates, distortion, thickness inequality, the visible opaque dark area of fluid of intraperitoneal.
Traditional Chinese medical science standard: with reference to Shanghai City Chinese traditional medical diagnose routine, meet the traditional Chinese medical science " tympanites " diagnostic criteria, promptly vexed, the abdomen of gastral cavity abdominal distention expands; Indigestion and loss of appetite, weak; Oliguria, or blue veins exposes.And according to empty, the real two kinds of pattern of syndrome of following standard branch.
[excess syndrome] primary symptom: distention and fullness in the abdomen, collapse tight or by pain; Constipation with dry stool or viscous not well (being no more than every day 2 times); Yellow fur or thick greasy.Deep and forceful pulse.Inferior disease: xerostomia hardship; Hypochondriac pain.
[deficiency syndrome] primary symptom: gastral cavity abdomen feeling of fullness does not relax, or likes warm pain relieved by pressing; Thin or the increased frequency (every day is above 3 times) in big loose stool; White and slippery fur or few tongue, deep-thready pulse or stringy and thready pulse number.Inferior disease: fear of cold is afraid of cold, and face is impractical; Vertigo and tinnitus, dysphoria with feverish sensation in the chest palms and soles; Indigestion and loss of appetite lazy speech, fatigue and weak.
Primary symptom more than 1, inferior disease are more than 2; Or primary symptom gets final product more than 2.
Include standard in: 18-65 years old ages sex; Western medicine diagnose is a cirrhotic ascites, and tcm diagnosis is a tympanites.The signature Informed Consent Form.
Exclusion standard: allly do not meet any person of the standard of including in; The cirrhotic ascites person that non-hepatitis virus, schistosomicide, medicine, ethanol and chemical poisoning cause; Merge cardiovascular, lung, kidney, nervous system serious disease and the serious primary disease person of blood system and psychosis, tumor patient; Gestation and women breast-feeding their children.
Standard comes off: withdraw from test voluntarily, ascites exists and does not finish the omnidistance observation of clinical trial as yet, is the case that comes off.Though finish navel-applying therapeutic the course of treatment in advance less than, ascites disappears, be not considered as the case that comes off.
The rejecting standard: though finish entire test, data is imperfect.
Grouping and medication: clinical diagnosis cirrhotic ascites patient 77 examples, district's component layers random packet is excess syndrome observation group and matched group, deficiency syndrome observation group and matched group (table 1).On the basis of general treatment (diuretic is defined as " spironolactone ", and every day, consumption was no more than 80mg), excess syndrome observation group adopts above excess distension side cataplasma cataplasma, deficiency syndrome group observation group to adopt deficiency-distension side's cataplasma to apply umbilicus, and matched group not umbilicus applies 30 days courses of treatment.Actual case 62 examples of finishing, 10 examples that come off are rejected 5 examples.
Observed content:
Cardinal symptom: abdominal distention, diet, aerofluxus and stool etc.
Abdominal circumference: measure every day 1 time.
Urine amount: record 24h urine amount.
Body weight: weighing every day 1 time.
Serum liver function: treatment front and back each 1 time.
B ultrasonic: treatment front and back each 1 time.
Curative effect judging standard:
Effective I level: ascites disappears fully, the ultrasound diagnosis feminine gender, and cardinal symptom disappears, level before the weight recovery ascites.
Effective II level: the ascites major part disappears, B ultrasonic lie on one's side spy and ascites, flatly crouch negatively, symptom is obviously improved, and lose weight more than the 2kg, or abdominal circumference dwindles〉5cm.
Effective III level: ascites disappears to some extent, B ultrasonic is flat lie on one's side spy and ascites and ascites feminine gender before the liver, and symptom is slightly improved, body weight alleviates＜2kg to some extent, or abdominal circumference dwindles〉3cm.
Invalid: ascites reduces not obvious, and doing well,improving is invalid, and body weight and abdominal circumference do not have significant change before and after the treatment.The result shows: 1) obviously improve disease.Cirrhotic ascites patient is deficiency syndrome or excess syndrome no matter, applies that final vacuum in 3-7 days significantly increases behind the umbilicus, abdominal distention alleviates, appetite is significantly promoted etc.2) promote that ascites disappears.Show as: compare with matched group respectively, this preparation shortens the ascites regression time after applying umbilicus; Reduce abdominal circumference; Promote the urine amount to drain.3) sb.'s illness took a favorable turn to promote cirrhotic ascites.According to comprehensive therapeutic effect criterions such as B ultrasonic, symptom and signs, apply umbilicus group effective percentage apparently higher than corresponding matched group.4) to the influence of liver function.Applying the umbilicus group has certain reduction serum total bilirubin and ALT horizontal force, but compares no significant difference with matched group.5) toxicity.Skin erythema and blister appear in totally 2 routine patients, and after temporarily stopping using 2 days or being coated with outside iodized oil, symptom disappears.Table 1 is the clinical trial physical data.Table 2 is that the curative effect and the actual course of treatment of umbilicus to cirrhotic ascites excess syndrome and deficiency syndrome applied with excess distension side's cataplasma by deficiency-distension side.To be deficiency-distension sides apply umbilicus with excess distension side's cataplasma to table 3 that the influence of body weight, abdominal circumference and the urine amount of cirrhotic ascites excess syndrome and deficiency syndrome (is treated the front and back difference, x ± s).
Table 1.
Test group and matched group comparison in test group and matched group, the excess syndrome in the deficiency syndrome, the equal no significant difference of age and sex is through Fisher ' s Exact check, P=1.000.
Table 2
Annotate: deficiency syndrome matched group and test group curative effect compare, and Mann-Whitney U checks Z=-2.252, P=0.028.Excess syndrome matched group and test group curative effect compare, Z=-2.579, P=0.010.Come off and reject case and carry out statistical analysis by engineering noise.The actual course of treatment, relatively t checked,
*Compare with corresponding matched group P＜0.05.
Table 3
*Compare with corresponding matched group P＜0.05.
Embodiment 3
The typical case implements medical record for example:
Example 1 cirrhotic ascites (deficiency syndrome)
Patient male 60 years old, accepts for medical treatment in May, 2004 because of " abdominal distention, stomachache 4 days " and to be admitted to hospital.Surplus patient's hepatitis B medical history 20 year, surplus the liver cirrhosis medical history 5 year.Found liver cirrhosis, splenomegaly, ascites before 5 years, once take in certain hospital protect the liver, the diuretic Chinese and western drugs, sb.'s illness took a favorable turn, has repeatedly in the time of then.Abdominal distention when this shows effect, stomachache obviously, epigastric distension and distress, the decreased food intake of receiving is few, hypourocrinia does not have hemorrhage performance, and is not obvious through the past medication effect, comes my institute's diagnosis and treatment.Admission examination: the skin yellow sclera, liver palm is obvious, the throat see have spider angioma several, abdominal tympanites, umbilicus week mild tenderness and rebound tenderness, shifting dullness (+), two lower limb pitting edemas.Light red, the greasy and thin fur of body of the tongue, stringy and thready pulse.Ultrasound diagnosis: liver cirrhosis changes, the flat 20cm of liquid before the liver, the flat flat 138cm of liquid that crouches.Liver function test: total protein 71g/L, albumin 22.4g/L, A/G0.46, Tbil74.9 μ mol/L, ALT157.Western medicine diagnose is " liver cirrhosis behind the chronic hepatitis B, liver function lose the compensatory phase ", and tcm diagnosis is " tympanites, a deficiency-distension ".
Be admitted to hospital the back with the soothing liver and strengthening spleen extract oral, and oral spironolactone 60mg/d, intravenous drip hepatocyte growth-promoting factors and albumin etc., the urine amount is increased to 1600ml/d by 900ml/d after 4 days, and body weight and abdominal circumference do not have significant change; Then increase with the present invention " deficiency-distension side " cataplasma and apply umbilicus, changed 1 time in per 3 days, the urine amount is increased to 2400-3000ml/d, and the aerofluxus increase, and abdominal distention obviously alleviates, and stomachache disappears, and diet increases, and body of the tongue is light red, yellow and thin fur, stringy and thready pulse.After 1 month, body weight is reduced to 64kg by 72kg, and abdominal circumference is reduced to 94cm by 105cm, and the urine amount remains on about 2000ml/d, lower limb do not have pitting edema, and B ultrasonic shows no obvious ascites, liver function test: total protein 76g/L, albumin 29.4g/L, A/G0.63, T.BiL 60.4 μ mol/L, ALT 61.Then leave hospital to be almost recovered.
Example 2 cirrhotic ascites (excess syndrome)
Patient male, 32 years old, because of " abdominal distention, right side of body dull pain, weak, companion's cough 1 day increased the weight of 3 days " is admitted to hospital.Previously the chronic hepatitis b disease history is 6 years, the hepatitis b virus marker positive (great three positive), and liver function is unusual repeatedly, and once with treatments such as the liver protecting and ALT lowering, interferon, effect is very unobvious.Feel right side of body portion pain in the time of in the recent period, weak, and abdominal distention is obvious, the food of receiving is relatively poor, cough, heating etc.Admission examination: the slight xanthochromia of skin sclera, there are not obvious liver palm and spider angioma, the abdominal part protuberance, abdomen is soft, does not have obvious tenderness and percussion pain, shifting dullness (+), two lower limb do not have the significant depressions edema.Red tongue, yellow and greasy fur, wiry and frequent pulse.Ultrasound diagnosis: liver cirrhosis changes, the flat 19cm of liquid before the liver, the flat flat 67cm of liquid that crouches.Liver function test: total protein 46.2g/L, albumin 22.8g/L, A/G 0.97, T.BiL47.7 μ mol/L, ALT 42.Western medicine diagnose is " liver cirrhosis behind the chronic hepatitis B, liver function lose the compensatory phase ", and tcm diagnosis is " tympanites, an excess distension (retention of damp-heat in the interior) ".
Be admitted to hospital the back with the clearing away heat-damp and promoting diuresis extract oral, and oral spironolactone 20mg/d, and umbilicus week external application was changed 1 time with the present invention " excess distension side " cataplasma in per 3 days.The urine amount is increased to 2300ml/d by 1500ml/d after 4 days, and body weight and abdominal circumference reduce gradually, and aerofluxus obviously increases, and abdominal distention alleviates, and diet is promoted.After 1 month, body weight is reduced to 57kg by 61.5kg, and abdominal circumference is reduced to 67cm by 75cm, and the urine amount remains on about 2000ml/d.B ultrasonic shows no obvious ascites; Liver function test: total protein 63.8g/L, albumin 31g/L, A/G 0.95, T.BiL48 μ mol/L, ALT 35.Body of the tongue is light red, yellow and thin fur, stringy and thready pulse.Then leave hospital to be almost recovered.
Claims (2)
1. improve the Chinese medicine for external application of cirrhotic ascites, it is characterized in that being used for the external preparation of cirrhotic ascites deficiency syndrome, by the Chinese crude drug Radix Astragali, RADIX ACONITI LATERALIS PREPARATA, Cortex Cinnamomi, Rhizoma Cyperi, Flos Caryophylli, Borneolum Syntheticum and Moschus extractum and substrate are made, and described crude drug weight proportion is:
Radix Astragali 20-500g RADIX ACONITI LATERALIS PREPARATA 20-500g
Cortex Cinnamomi 20-500g Rhizoma Cyperi 20-500g
Natural or the artificial Moschus 200-500mg of Flos Caryophylli 20-500g Borneolum Syntheticum 4-100g
Described matrix components is:
Glycerol 20-40g NP-700 or NP600 2-5g tartaric acid 0.1-0.3g
Distilled water 50-70ml aluminium hydroxide 0.2-0.5g.
2. by the described preparation method of improving the Chinese medicine for external application of cirrhotic ascites of claim 1, it is characterized in that comprising the steps:
1) drug treating: get Radix Astragali, RADIX ACONITI LATERALIS PREPARATA, Cortex Cinnamomi, Rhizoma Cyperi 4 flavors and decoct with water 2 times, merge filtrate twice, be condensed into extractum; The Borneolum Syntheticum porphyrize is crossed 60 orders with top sieve, adds extractum and mixes thoroughly; Flos Caryophylli is extracted Flos Caryophylli volatile oil with steam distillation, and volatile oil adds in the extractum to be mixed thoroughly; Moschus grinds well porphyrize with low amounts of water, adds extractum and mixes thoroughly;
2) substrate preparation: aluminium hydroxide added fill in the container of glycerol, fully mix, add NP-700 or NP-600 continue again to mix solution 1.; Tartaric acid is placed container, add dissolved in distilled water; Get the equal portions tartaric acid solution respectively, add above-mentioned 1. in, add abundant mixing at every turn; After all equal portions tartaric acid solutions add, fully stir;
3) formulation preparation: behind substrate and the abundant mixing of medicine, coat on the non-woven fabrics, cover isolating membrane and make cataplasma 20 subsides.
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| CN105833159B (en) * | 2015-11-26 | 2020-03-24 | 上海中医药大学附属曙光医院 | Medicine for treating ascites due to cirrhosis and production method thereof |
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| Title |
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| 潘传芳等.肝硬化腹水的敷脐疗法.中西医结合肝病杂志.2004, * |
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| CN101422549A (en) | 2009-05-06 |
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