CN101406580B - Anticancer pain-relieving Chinese medicine and preparation method thereof - Google Patents
Anticancer pain-relieving Chinese medicine and preparation method thereof Download PDFInfo
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- CN101406580B CN101406580B CN2008101598888A CN200810159888A CN101406580B CN 101406580 B CN101406580 B CN 101406580B CN 2008101598888 A CN2008101598888 A CN 2008101598888A CN 200810159888 A CN200810159888 A CN 200810159888A CN 101406580 B CN101406580 B CN 101406580B
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Abstract
The invention relates to an anticancer analgesic traditional Chinese medicine, which comprises the following raw materials in weight portion: 850 to 1,100g of oldenlandia diffusa, 900 to 1150g of herba scutellariae barbatae, 400 to 550g of nux vomica, 450 to 600g of pangolin, 400 to 550g of radix aconiti feri, 460 to 580g of frankincense, 430 to 560g of myrrh, 420 to 530g of centipede, 25 to 34g of cantharis, 85 to 120g of borneol, 440 to 560g of Typhonium giganteum, 410 to 520g of subprostrate sophora, 460 to 560g of scorpion, 200 to 290g of asafetida, and 40 to 62g of catechu. The anticancer analgesic traditional Chinese medicine has apparent analgesic functions on cancerous pain at middle and late periods, has good defervescence function on cancerous fever, and contributes to settling the minds of patients, increasing the appetite, improving sleeping, improving the immunity of human bodies, promoting blood circulation, removing blood stasis, relieving pain and reducing swelling.
Description
Technical field
The present invention relates to a kind of anticancer analgetic Chinese medicine and preparation method thereof, belong to tcm field.
Background technology
Cancerous pain be cancer patient in, the outstanding behaviours in late period, its incidence rate accounts for more than 80% of whole cancer patient.Late period, carcinomas pain was typical case's representative of altauna disease.After chronic, intractable pain has taken place in cancer patient, often exist serious discomfort of body and psychic pain simultaneously, violent or/and secular pain without stop can make the function of each each system of organ of human body get muddled again and unusually, the patient suffering unbearably.The pain that cancer patient takes place is not only brought insufferable misery to patient, and is brought immense pressure psychologically, mentally on health, directly influence patient's life and quality of life.
At present, the method of anticancer analgetic and medicine have varied, facts have proved that Drug therapy is to prevent the main means of cancer pain, wherein real desirable and satisfied still by depending on narcotics, as codeine, dolantin and morphine etc., though these medicines can be removed patient's misery, but the use of this quasi drugs is strictly controlled, and be difficult to satisfy patient's actual needs, and patient is easy to generate dependency, the easy addiction of life-time service, its hazardness is bigger.
Summary of the invention
Technical problem to be solved by this invention is the problem at above-mentioned existence, provides a kind of and has significant analgesia role, cancer fever is had anticancer analgetic Chinese medicine of good antipyretic effect and preparation method thereof
For solving the problems of the technologies described above, the technical solution adopted in the present invention is: a kind of anticancer analgetic Chinese medicine is characterized in that: described Chinese medicine comprises the raw material of following weight part ratio: Herba Hedyotidis Diffusae 850-1100g, Herba Scutellariae Barbatae 900-1150g, Semen Strychni 400-550g, Squama Manis 450-600g, Radix Aconiti Kusnezoffii 400-550g, Olibanum 460-580g, Myrrha 430-560g, Scolopendra 420-530g, Mylabris 25-34g, Borneolum Syntheticum 85-120g, Herba Typhonii gigantei 440-560g, Radix Sophorae Tonkinensis 410-520g, Scorpio 460-560g, Resina Ferulae 200-290g and catechu 40-62g.
A kind of technical scheme of optimization, described Chinese medicine comprises the raw material of following weight part ratio: Herba Hedyotidis Diffusae 900-1050g, Herba Scutellariae Barbatae 950-1100g, Semen Strychni 450-530g, Squama Manis 480-550g, Radix Aconiti Kusnezoffii 460-530g, Olibanum 480-550g, Myrrha 460-530g, Scolopendra 460-520g, Mylabris 28-32g, Borneolum Syntheticum 90-110g, Herba Typhonii gigantei 470-540g, Radix Sophorae Tonkinensis 440-510g, Scorpio 470-540g, Resina Ferulae 220-270g and catechu 46-56g.
A kind of concrete prioritization scheme, described Chinese medicine comprises the raw material of following weight part ratio: Herba Hedyotidis Diffusae 990g, Herba Scutellariae Barbatae 985g, Semen Strychni 490g, Squama Manis 510g, Radix Aconiti Kusnezoffii 505g, Olibanum 515g, Myrrha 505g, Scolopendra 495g, Mylabris 29g, Borneolum Syntheticum 98g, Herba Typhonii gigantei 506g, Radix Sophorae Tonkinensis 495g, Scorpio 505g, Resina Ferulae 245g and catechu 48.5g.
Described anticancer analgetic preparation method of Chinese medicine may further comprise the steps:
A, take by weighing each raw material respectively according to weight portion;
B, be soaked in water after Semen Strychni scraped unhaired hide, change water every day once, soak to take out after 2-3 days and dry in the shade, fried with Oleum sesami to crisp, standby;
C, Olibanum, Myrrha and Mylabris is dried, standby with the pot stir-fry;
D, with remaining raw material and fried after Semen Strychni and the Olibanum of fry doing, Myrrha and Mylabris mix, pulverize with pulverizer, crossing 120 mesh sieves becomes smalls;
E, divide bag hermetic package with above smalls.
The using method of anticancer analgetic Chinese medicine may further comprise the steps:
A, the Chinese medicine smalls is reconciled into pasty state with vinegar or Ovum Gallus domesticus album, spread on plastic paper or gauze, thickness is 0.6cm-0.8cm, be applied to patient primary carcinoma corresponding acupuncture point or be placed directly in painful area;
B, use the hot water bag hot compress then.
The pharmacology of above Chinese medicine is:
Wherein, the directly anticancer growth of Herba Hedyotidis Diffusae and Herba Scutellariae Barbatae, enhancing human body immunity function are widely used in various malignant tumor, and do not have obvious toxic and side effects; Semen Strychni, Scolopendra and Radix Aconiti Kusnezoffii three herbal medicines have the effect of removing obstruction in the collateral to relieve pain, mass dissipating and swelling eliminating, Semen Strychni, Scolopendra and Radix Aconiti Kusnezoffii compatibility can be treated the pain that multiple cancer comprises that metastatic carcinoma causes, Scolopendra in this prescription can also be resisted the toxicity of the brucine (strychnine) in the Semen Strychni, and do not influence the effect of strychnine, the two compatibility had both kept the composition of effective anticancer analgetic, had promoted analgesic activity again, simultaneously, Semen Strychni also has the effect that improves patient's appetite; Squama Manis, Olibanum, Myrrha and Mylabris have the effect of blood circulation promoting and blood stasis dispelling, can improve the high viscosity and high coagulant state of malignant tumor patient blood, wherein the metabolism of all right interfere with cancer cells protein of the cantharidin in the Mylabris and nucleic acid; Borneolum Syntheticum has the analgesic effect of having one's ideas straightened out, dispel the heat; Herba Typhonii gigantei, Radix Sophorae Tonkinensis, Scorpio, Resina Ferulae and catechu compatibility use can improve whole immunologic function, and has common anticancer analgetic effect, improves the stress state of human body in slight illness.
The present invention adopts above technical scheme, and centering, late period, cancerous pain had significant analgesia role; Cancer fever there is the good function of bringing down a fever; Help stablizing patient's emotion, stimulating appetite improves sleep, improves the immunity of human body, blood circulation promoting and blood stasis dispelling, and alleviating pain and detumescence, thus improve patient's quality of life and prolong its life.
Below in conjunction with the specific embodiment to technical scheme further instruction of the present invention:
The specific embodiment
Embodiment 1, a kind of anticancer analgetic Chinese medicine comprises the raw material of following weight part ratio: Herba Hedyotidis Diffusae 990g, Herba Scutellariae Barbatae 985g, Semen Strychni 490g, Squama Manis 510g, Radix Aconiti Kusnezoffii 505g, Olibanum 515g, Myrrha 505g, Scolopendra 495g, Mylabris 29g, Borneolum Syntheticum 98g, Herba Typhonii gigantei 506g, Radix Sophorae Tonkinensis 495g, Scorpio 505g, Resina Ferulae 245g and catechu 48.5g.
This Chinese medicine adopts the following steps preparation:
A, take by weighing each raw material respectively according to weight portion;
B, be soaked in water after Semen Strychni scraped unhaired hide, change water every day once, soak to take out after 2 days and dry in the shade, fried with Oleum sesami to crisp, standby;
C, Olibanum, Myrrha and Mylabris is dried, standby with the pot stir-fry;
D, with remaining raw material and fried after Semen Strychni and the Olibanum of fry doing, Myrrha and Mylabris mix, pulverize with pulverizer, crossing 120 mesh sieves becomes smalls;
E, the every 5g sealed packet of above smalls is dressed up one bag.
Choose 126 examples and carry out test of cure because of cancerous pain and fever patient, picked at random 85 examples are organized as treatment, and 41 examples are organized in contrast.
(1) treatment is organized among the 85 routine patients, male's 47 examples, and women's 38 examples, age 30-82 year, 53.7 years old mean age, use the Chinese medicine of above component preparation, adopt following administrated method:
The Chinese medicine smalls is reconciled into pasty state with vinegar, spread on gauze, thickness is 0.8cm, be applied to patient primary carcinoma corresponding acupuncture point or be placed directly in painful area, use the hot water bag hot compress then, treat the moistening back of the reuse vinegar continuation treatment of the dried slightly back of medicated powder, every dose with 2 days, 10 days is a course of treatment, each 2 bags.
The result: pain disappears or/and 42 examples of significant curative effect are arranged, and accounts for 49.41%; Pain relief is or/and 41 examples that alleviate account for 48.24%, and total effective rate is 97.65%; Nonresponder's 2 examples account for and all bring down a fever after 2.35%, 16 routine heating person treats, and effective percentage is 100%.
(2) in matched group 41 examples, male's 26 examples, women's 15 examples in age 26-89 year, 55.51 years old mean age, select for use the phase I medicine aspirin and the second stage common drug bucinnazine of cancer pain control oral.
The result: tangible 18 examples of pain relief curative effect, account for 43.9%, 9 examples that curative effect is general account for 21.95%, and total effective rate is 65.85%, and invalid 14 examples account for 34.15%.
Embodiment 2, a kind of anticancer analgetic Chinese medicine comprises the raw material of following weight part ratio: Herba Hedyotidis Diffusae 850g, Herba Scutellariae Barbatae 900g, Semen Strychni 400g, Squama Manis 450g, Radix Aconiti Kusnezoffii 400g, Olibanum 460g, Myrrha 430g, Scolopendra 420g, Mylabris 25g, Borneolum Syntheticum 85g, Herba Typhonii gigantei 440g, Radix Sophorae Tonkinensis 410g, Scorpio 460g, Resina Ferulae 200g and catechu 40g.
Prepare this Chinese medicine according to the preparation method identical with embodiment 1.
Choose 126 examples in addition and carry out test of cure because of cancerous pain and fever patient, picked at random 80 examples are organized as treatment, and 46 examples are organized in contrast.
(1) treatment is organized among the 80 routine patients, male's 41 examples, and women's 39 examples in age 33-80 year, 52.2 years old mean age, are used this Chinese medicine according to the using method identical with embodiment 1.
The result: pain disappears or/and 38 examples of significant curative effect are arranged, and accounts for 47.5%; Pain relief is or/and 39 examples that alleviate account for 48.75%, and total effective rate is 96.25%; Nonresponder's 3 examples account for and all bring down a fever after 3.75%, 10 routine heating person treats, and effective percentage is 100%.
(2) in matched group 46 examples, male's 28 examples, women's 18 examples, in age 28-84 year, 54.37 years old mean age, the medicine of selecting for use is identical with embodiment 1 used medicine.
The result: tangible 21 examples of pain relief curative effect, account for 45.65%, 11 examples that curative effect is general account for 23.91%, and total effective rate is 69.56%, and invalid 14 examples account for 30.44%.
Embodiment 3, a kind of anticancer analgetic Chinese medicine comprises the raw material of following weight part ratio: Herba Hedyotidis Diffusae 1100g, Herba Scutellariae Barbatae 1150g, Semen Strychni 550g, Squama Manis 600g, Radix Aconiti Kusnezoffii 550g, Olibanum 580g, Myrrha 560g, Scolopendra 530g, Mylabris 34g, Borneolum Syntheticum 120g, Herba Typhonii gigantei 560g, Radix Sophorae Tonkinensis 520g, Scorpio 560g, Resina Ferulae 290g and catechu 62g.
Prepare this Chinese medicine according to the preparation method identical with embodiment 1.
Choose 126 examples in addition and carry out test of cure because of cancerous pain and fever patient, picked at random 88 examples are organized as treatment, and 38 examples are organized in contrast.
(1) treatment is organized among the 88 routine patients, male's 46 examples, and women's 42 examples in age 34-81 year, 54.1 years old mean age, are used this Chinese medicine according to the using method identical with embodiment 1.
The result: pain disappears or/and 42 examples of significant curative effect are arranged, and accounts for 47.73%; Pain relief is or/and 43 examples that alleviate account for 48.86%, and total effective rate is 96.59%; Nonresponder's 3 examples account for and all bring down a fever after 3.41%, 13 routine heating person treats, and effective percentage is 100%.
(2) in matched group 38 examples, male's 22 examples, women's 16 examples, in age 30-82 year, 55.42 years old mean age, the medicine of selecting for use is identical with embodiment 1 used medicine.
The result: tangible 17 examples of pain relief curative effect, account for 44.74%, 9 examples that curative effect is general account for 23.68%, and total effective rate is 68.42%, and invalid 12 examples account for 31.58%.
From above three embodiment as can be seen: the moderate and person that do not have an intense pain in early days of this Chinese medicine centering, patients with advanced cancer has significant analgesia role, no addiction, the consumption that can replace oral analgesics and minimizing injecting narcotic, stronger to cancer its antipyretic effect that generates heat, and minimizing pain, can reduce body temperature rapidly, can make patient's stimulating appetite and improve sleep.
Among the above embodiment, can also the Chinese medicine smalls be reconciled into pasty state with Ovum Gallus domesticus album, through experiment confirm, be in harmonious proportion Chinese medicine smalls viscosity height with Ovum Gallus domesticus album, easily be fixed on the health, but the Chinese medicine smalls that is in harmonious proportion with vinegar, easily absorb, produce effects is fast, effect is lasting, so the better effects if of using vinegar to be in harmonious proportion.
Claims (4)
1. anticancer analgetic Chinese medicine, it is characterized in that: the pharmacodynamic raw materials of described Chinese medicine and weight part ratio are: Herba Hedyotidis Diffusae 850-1100g, Herba Scutellariae Barbatae 900-1150g, Semen Strychni 400-550g, Squama Manis 450-600g, Radix Aconiti Kusnezoffii 400-550g, Olibanum 460-580g, Myrrha 430-560g, Scolopendra 420-530g, Mylabris 25-34g, Borneolum Syntheticum 85-120g, Herba Typhonii gigantei 440-560g, Radix Sophorae Tonkinensis 410-520g, Scorpio 460-560g, Resina Ferulae 200-290g and catechu 40-62g.
2. a kind of anticancer analgetic Chinese medicine as claimed in claim 1, it is characterized in that: the pharmacodynamic raw materials of described Chinese medicine and weight part ratio are: Herba Hedyotidis Diffusae 900-1050g, Herba Scutellariae Barbatae 950-1100g, Semen Strychni 450-530g, Squama Manis 480-550g, Radix Aconiti Kusnezoffii 460-530g, Olibanum 480-550g, Myrrha 460-530g, Scolopendra 460-520g, Mylabris 28-32g, Borneolum Syntheticum 90-110g, Herba Typhonii gigantei 470-540g, Radix Sophorae Tonkinensis 440-510g, Scorpio 470-540g, Resina Ferulae 220-270g and catechu 46-56g.
3. a kind of anticancer analgetic Chinese medicine as claimed in claim 2, it is characterized in that: the pharmacodynamic raw materials of described Chinese medicine and weight part ratio are: Herba Hedyotidis Diffusae 990g, Herba Scutellariae Barbatae 985g, Semen Strychni 490g, Squama Manis 510g, Radix Aconiti Kusnezoffii 505g, Olibanum 515g, Myrrha 505g, Scolopendra 495g, Mylabris 29g, Borneolum Syntheticum 98g, Herba Typhonii gigantei 506g, Radix Sophorae Tonkinensis 495g, Scorpio 505g, Resina Ferulae 245g and catechu 48.5g.
4. anticancer analgetic preparation method of Chinese medicine as claimed in claim 1 is characterized in that: described preparation method may further comprise the steps:
A, take by weighing each pharmacodynamic raw materials respectively according to weight portion;
B, be soaked in water after Semen Strychni scraped unhaired hide, change water every day once, soak to take out after 2-3 days and dry in the shade, fried with Oleum sesami to crisp, standby;
C, Olibanum, Myrrha and Mylabris is dried, standby with the pot stir-fry;
D, with remaining raw material and fried after Semen Strychni and the Olibanum of fry doing, Myrrha and Mylabris mix, pulverize with pulverizer, crossing 120 mesh sieves becomes smalls;
E, divide bag hermetic package with above smalls.
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| CN102579999B (en) * | 2012-03-21 | 2013-09-04 | 山东省千佛山医院 | Medicine for treating carcinous fever and preparation method thereof |
| CN103071025A (en) * | 2013-01-10 | 2013-05-01 | 济南康众医药科技开发有限公司 | Medicine for curing excessive toxic heat type cancerous fever |
| CN104800393A (en) * | 2015-04-22 | 2015-07-29 | 泰山医学院 | Traditional Chinese medicine for treating leukemia cancer pain |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1252301A (en) * | 1999-10-10 | 2000-05-10 | 黄晓维 | Cancer eliminating ointment compounding process |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1252301A (en) * | 1999-10-10 | 2000-05-10 | 黄晓维 | Cancer eliminating ointment compounding process |
Non-Patent Citations (1)
| Title |
|---|
| 何玉梅等.中药外治法在癌痛治疗中的应用.《中日友好医院学报》.2000,第14卷(第2期),114-116. * |
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