CN101405045A - Inhaler for powdery substances - Google Patents

Abstract

The invention relates to an inhalator (1) for powdery substances (33), especially medical substances. Said inhalator comprises a substance reservoir chamber (27) and a metering chamber (34). Said metering chamber is configured as a crossbore (35) of a rod (36) and can be displaced from a filling position (B) to a discharge position (E), in which discharge position (E) the metering chamber (34) is positioned in an air flow channel (21). The aim of the invention is to improve said inhalator, especially with regard to the filling or emptying of its metering chamber, even when particles of smallest dust-like grain size are used. For this purpose, at least a part of the reservoir chamber wall (28) is displaced in the direction of the rod (36) when the inhalator (1) is actuated.

Description

The inhaler that is used for powdered rubber

Technical field

According to the preamble of independent claims, the present invention relates to a kind of particularly inhaler of the powdered rubber of medicine that is used for.

Background technology

The inhaler of type in question is known.For example can be with reference to US5239992.This patent specification discloses and has described a kind of inhaler with bar, and this bar comprises the dosage chamber and can be displaced to evacuate position from filling position.The emptying of dosage chamber dislocation and dosage chamber is depended on by the patient and is sucked the suction that produces dearly.Realize that by means of air-flow the filling of dosage chamber and its emptying are insecure.

Summary of the invention

According to known systems, the objective of the invention is further to improve common inhaler, particularly about of the filling of dosage chamber at evacuate position, and particularly its emptying.

Above-mentioned purpose at first realizes by the theme of claim 1.Because this structure, one or more dosages chamber of littler cross-sectional area also can be filled and emptying reliably, and for the powder of possible smallest particles size, this in addition also be possible.Scheme according to claim 2 is optimum in this regard.This bar has a plurality of adjoining lands and is positioned at dosage chamber on the bar, these dosage chambers adjoining land between the discharging period of energization moves to evacuate position, and be blown one by one by the positive air pressure in the gas channel, therefore realized being emptied completely effectively of each dosage chamber., particularly can be filled and the powder of fine particle because one or more dosages chamber can be filled accurate part iff being, the distribution of material is similar to the distribution of the inhaler that is provided with aerosol tube (aerosol cartridge) so.The effect that the positive air pressure that applies in the process of actuated inhaler produces is, the material that is assigned with is discharged effectively from the dosage chamber, a plurality of in addition dosages chamber has configuration in a row, and adjoining land is through evacuate position in the longitudinal extent of bar, this bar has the dosage chamber that material is blown effect during being included in its dislocation, and some is as the action of machine gun.In addition, under air pressure the dosage chamber blow out the fabulous distribution that has realized being transmitted material, this makes conversely may use the micronised powder material that is designed for directly entering pulmonary.This makes and the size that also may select the dosage chamber makes each chamber can receive general 0.03 to 0.2mg material.In preferred exploitation, provide for suck with the necessary suction air-flow of the material that is discharged from not directly around or evacuated area by gas channel flow, that is to say that bar is provided with the dosage chamber through this zone and this bar.On the contrary, when take place sucking, the suction air-flow under the negative pressure only is applied in the zone of the mixing portion that is associated with mouth or nose, and the material of cutting apart in mixing portion is promoted energetically by means of positive air pressure.

The theme of other claim makes an explanation below, but also is important in their independent the expression.

For example, in the exploitation of theme, provide rod to become flat rod, and in cross section length measured corresponding to many times of the width of cross measure, for example ten to 20 times.For example, preferably be provided with and have about 0.3 to 0.7mm and the bar of 0.5mm or 0.3mm thickness preferably.This flat rod can be made of plastic material, particularly rigid plastic material.Wherein the scheme made by metal material of flat rod is preferred.The dosage chamber that adjoining land is arranged on the longitudinal length of flat rod is set to the hole of the circular discs form of vertical view in the simplest mode, and the central axis in each hole is aimed at perpendicular to the flat sides of flat rod.

Bar passes the part that comprises the dosage chamber of material locker room, particularly bar, and the dosage chamber is immersed in the powdered rubber that is kept in the locker room thus.Preferably make the material of rubber like for example, thermoplastic elastomer (TPE) for example in addition by elastomeric material at this storage locular wall.When inhaler activated, the storage locular wall that this elasticity is fit to was along the direction of bar and thus along the direction bending of dosage chamber.This takes place by the storage locular wall that stands normal pressure at first, this normal pressure from outer radial act on this storage locular wall, this normal pressure also is used in evacuate position emptying dosage chamber.This normal pressure inhaler activate during produce and the form of positive air pressure preferably.In this regard, further provide the storage locular wall to be bent, at least in the zone in dosage hole, up to this wall near bar and have extruding thus and be kept at the effect that the material in the locker room enters the dosage chamber.Under case of bending, the part of storage locular wall is in abutting connection with the flat sides of bar, in the face of each unlimited cross section of dosage chamber.At this adjoining position, the part of storage locular wall has the effect of wiping in bar enters the dislocation process of evacuate position.This wiping is used for the accurate distribution of the material that will be discharged from, and preferably even before arriving evacuate position, produce this wiping.

In the preferable configuration of theme of the present invention, except standing normal pressure in the above described manner, the storage locular wall is made the direction bending along bar effectively.Be provided with thrust piece (thrust piece) for this purpose, this thrust piece from external action on the storage locular wall, be used for wall part preferably in abutting connection with the flat sides of bar.The effect that this locular wall stands thrust piece in this way effectively also helps to be filled in the dosage chamber that forms in the bar of center maintenance.

During each actuated inhaler, comprise that the bar of dosage chamber enters the dislocation of evacuate position, and pressure puts on the storage locular wall and is used to fill the dosage chamber.In this respect, invalid dislocation is set between inhaler actuation button and bar, the effect that has is: before bar is driven, by means of outer thrust piece with optionally apply air pressure and produce curving inwardly of storage locular wall.Thereby the dosage chamber is filled by means of thrust piece, and the storage locular wall is therebetween, yet preferably bar still is in resting position.Only after this filling and the invalid dislocation that is associated were finished, bar was pushed by the further dislocation of actuation button, so that the dosage chamber is incorporated into evacuate position.

Thrust piece preferably is provided with jaw, and these jaws have the composition surface, and these composition surfaces are parallel to the broad side walls surface of bar in the complete pivot position of thrust piece or extrusion position places, and a consequent result is that the dosage chamber is correctly filled.Another result has realized wiping position.Correspondingly the composition surface on the jaw is flat flat shape.

The actuation button of inhaler forms and makes that its head place at the inhaler shell is outstanding, be positioned at this above-head, and this actuation button can be by dislocation against back-moving spring.This allows inhaler preferably to remain on thumb as a whole and for example between the middle finger, middle finger rests on the actuation button and thumb is supported on shell with the actuation button facing surfaces on.Inhaler activated by pushing actuation button, and thrust piece pivots along the direction of bar by means of the continuous inclined-plane of actuation button.After a bit of invalid dislocation, the actuation button catch bar makes the filling position of dosage chamber from the locker room be displaced to evacuate position simultaneously.For the thrust piece that is provided with pivotable configuration, the continuous inclined-plane of actuation button correspondingly acts on the actuation button in the mode that pivots.Example as an alternative, thrust piece also can be configured such that these thrust pieces can be strictly dislocation point-blank radially, should realize by means of wedge effect towards radial displacement of bar.Particularly under the situation of thrust piece for the structure that pivots, these thrust pieces form in the mode of returning automatically, for example especially by means of the suitable elastic characteristic of the arm that supports thrust piece.Correspondingly, after no longer being applied in the load effect via continuous inclined-plane, these thrust pieces turn back to their home position once more, thereby discharge the storage locular wall, and this storage locular wall turns back to the home position once more owing to elastic characteristic.

Utilize the effective dislocation of actuation button in the inhaler shell, thereby set up positive air pressure, this positive air pressure is advanced and with the dislocation by bar material is blown out, and enters gas channel, enters the part of the contiguous bar of gas channel streamwise particularly.Thereby, being displaced to gas channel by the dosage chamber, normal pressure only reduces, and reduces at least in part, and material is blown simultaneously.Be arranged in the bar with a plurality of dosages chamber adjoining land in addition and mode that each dosage chamber is connected to gas channel thus in a continuous manner is accordingly, reduction with alternate mode generation positive air pressure, and material is discharged from from each dosage chamber, and this has produced and optimizedly that blow out has been discharged into environment with the cloud form material and is discharged into by in the air-flow that suck to produce.

Arrange the generation that has realized the positive air pressure that is used to blow out by piston/shell.This is to realize by the elastic piston ring at the inside stub area place of the cup-shaped wall of actuation button, and the inwall of itself and inhaler shell interacts, and this shell correspondingly forms the compressed air cylinder and is used for piston ring.Actuation button self forms the piston area on the inwall.In preferred configuration, thrust piece and locker room are arranged in the zone of the compressed air cylinder that produces in this way, and this helps following mode, and the locker room is acted on from the outside in this mode, and thrust piece is entered dosage chamber filling position by dislocation.

What comprise the dosage chamber can have the characteristic of valve by allochthonous point-blank bar.Air outlet slit in the zone of the cross section closed gas flow passage of bar can produce positive air pressure thus in the downward dislocation process of actuation button, face away from the waste side of gas channel.Only move in the gas channel, produce the opening action of valve-like, and under compressed air, produce and blow out accordingly when the dosage chamber of bar.If the dosage chamber suitably is spaced away from each other along the direction of motion of bar, open between the stage of blowing out in the valve-like of dosage chamber so, by the solid material of bar between two dosage chambers, the of short duration of flow path always occur and close.

The air intake valve is arranged on air outlet slit pass close point and holds between the outer casing space or compressed air cylinder of locker room, this air outlet slit closes close point and forms by gas channel zone and the interaction that runs transverse through this regional bar, in the big process of the strain mutually of the auxiliary cylinder space that returns dislocation and generation of the spring of actuation button, the air that this air intake valve allows to replenish flows into, but closes in effective actuation process of the discharging that is used for inhaled material.

Of the present invention to be proved that particularly advantageous theme launches be a following theme, and wherein setting device is provided, and is used for determining being introduced in the quantity of the dosage chamber of evacuate position.For example, particularly under the situation of such structure, a plurality of disposed chamber are arranged on the bar, and for example three to ten or more, make that observing disposed chamber's adjoining land from allochthonous direction is set up, and relative to each other equally spaced apart.Selectively measure as required, this has limited the dislocation of bar at longitudinal extent.Depend on the metering that needs really, thereby only a small amount of dosage chamber or more dosage chamber be introduced in evacuate position, that is to say that entering the dosage chamber stands the compressed-air actuated zone that blows out effect.Because each dosage chamber has very small amount of material, thereby can realize very accurate and variable dosage.For example, the come-at-able ring (accessible setting ring) that is provided with that is provided with a plurality of steps is provided, and is used for the dislocation motion of block actuation button.In the dislocation path corresponding mode limited with the block of button, the dosage chamber of specific quantity is through evacuate position.Actuation button is provided with counting assembly, for example preferably has the block projection, is used for interacting with the step that is provided with on the side.

In order to reduce the cross section of gas channel, particularly, can realize the structure of nozzle-like in the face of blowing out the end portion of end.For example, the cross section behind the reducing of gas channel end portion is probably corresponding to 0.5 to 0.9 of original cross section.In the expansion of theme of the present invention, provide by the straight gas channel of guiding with crossing and extended to the end channel part that the quilt with littler cross section is inclined upwardly and guides, this end channel part is stepped back in nasal tube, and ends at the free end of nasal tube.Because this structure, proposed inhaler can also be used for the application of nose.Because effective emptying of dosage chamber, the medicine that be inhaled into is blown, and enters nasal cavity especially.Advantageously help the further distribution of medicine simultaneously by the suction of nose.The effect that the aligning of the aligning that is tilted to guiding of end channel part and the nasal tube that holds this end channel part thus has is that inhaler can cosily be used, and for example also selectively makes in fact perpendicular alignmnet of inhaler axis in suction process.

For a kind of device of the amount that can check fill level or be assigned with is provided to user, in the expansion of theme of the present invention, provide indexing means, this indexing means activated when blowing out air pressure reaching.This indexing means is counted each individually actuating of inhaler, and the discharging of medicine wherein takes place.For example this indexing means has the scale such as calibration loop, the suction result that implemented of indication on this scale, or alternatively count down from the suction volume of maximum, show still and can carry out sucting number.Indexing means depends on to reach and blows out air pressure and activated, and produces before the dosage chamber of filling arrives about the transit area of gas channel with being right after and blows out air pressure.Thereby, indexing means be right after before medicine is transferred to gas channel, and before effectively the blowing out of medicine, be switched with correspondingly being right after.On the other hand, make when the degree of medicine ejection does not take place if trigger only is actuated to, that is to say trigger return dislocation after only alternatively fill the dosage chamber, the switching of indexing means does not take place.In the structure that provides by means of example, this is to begin by the counting finger that acts on the indexing means, the most advanced and sophisticated divided wheel that arrives indexing means greatly when the allochthonous beginning of bar of this finger, the dislocation of this bar makes the dosage chamber of filling enter in the zone of gas channel.The counting finger correspondingly is positioned at apart from divided wheel a distance, and this distance can overcome by the actuating of trigger, and has the dislocation of following of the bar that comprises the dosage chamber, and generation simultaneously blows out air pressure.

In preferred structure, the indicator of indexing means is a calibration loop, and this calibration loop is with respect to inhaler axis concentric alignment, and forms in inside with the form of ring gear, is used for along the circumferencial direction of rotation dislocation step by step, and interacts with divided wheel.In preferred structure, divided wheel forms with the form of the calibration loop of worm gear form rotation dividing apparatus.Thereby transmission in the middle of no longer needing is used for based on rectilinear motion, and the finger by indexing means changes into circus movement with respect to the axis transverse guidance with the actuating of divided wheel.Rely on this structure, particularly indexing means, can progressively reduce or progressively increase to the transmission of limb.

Description of drawings

The present invention is based on accompanying drawing and described in more detail hereinafter, accompanying drawing is only represented a plurality of exemplary embodiments, and wherein:

Fig. 1 shows the inhaler that is used for powdered rubber among first embodiment vertical cross-section at the initial position of unloaded;

Fig. 2 show corresponding with Fig. 1 but after removing protection mouth of pipe medicated cap for the sectional view in first centre position between period of energization at inhaler, wherein the dosage chamber is filled with material;

Fig. 3 shows from the zoomed-in view of the area I II of Fig. 2 intercepting;

Fig. 4 shows along the cross section of the line IV-IV among Fig. 3;

Fig. 5 shows the sketch map after the distribution that further activates dislocation and material that follows Fig. 2 closely;

Fig. 6 shows from the zoomed-in view of the regional VI of Fig. 5 intercepting;

Fig. 7 shows the sketch map for the centre position during returning dislocation that follows Fig. 5 closely;

Fig. 8 shows the perspective view of keeper, has locker room and the thrust piece and the bar that are connected to this locker room on this keeper, and this bar comprises dosage chamber and spiral back-moving spring;

Fig. 9 shows the decomposition view based on Fig. 8;

Figure 10 shows the perspective view of the inhaler among second embodiment;

Figure 11 shows the part decomposition view according to the inhaler of Figure 10;

Figure 12 shows inhaler and the corresponding vertical cross-section diagram of Fig. 1 that is used for another embodiment that snuffing goes into;

Figure 13 shows inhaler among another embodiment with indexing means in the vertical cross-section of initial position;

Figure 14 shows the zoomed-in view of the regional XIV among Figure 13;

But Figure 15 shows the view of general corresponding actuated position at inhaler with Figure 14, and wherein indexing means is counted the pointer actuating;

Figure 16 shows the partial cross section perspective view according to Figure 15;

Figure 17 shows along the sectional view of the line XVII-XVII among Figure 15;

Figure 18 shows the side view of the divided wheel of indexing means; With

Figure 19 shows the perspective view of divided wheel.

The specific embodiment

The inhaler 1 that is shown and described is embodied as a kind of portable ground pocket device, and this inhaler 1 has cylinder blanket 2, extends the outstanding mouth of pipe 3 of approximate radial from this cylinder blanket.The common form of inhaler 1 is generally corresponding to the form of the inhaler that is provided with the aerosol tube.The mode of inhaler 1 operation is also correspondingly adopted, and is obvious for user.

Therefore inhaler 1 has actuation button 4, and this actuation button is held common housing axis x, and laterally aims at respect to this axis x, and this actuation button is outstanding and relative with opposite face (counte-face) 5 at outer casing bottom place above shell 2.The discharging of material realizes along the dislocation of the direction of the opposite face on the bottom surface 5 along axis x by actuation button 4.

Shell 2 forms the cylinder-shaped body of hollow, and in the exemplary embodiment that illustrates, this main body has round-shaped in vertical view.Other form also is possible except this circular form in vertical view, for example also may be ellipse or polygon form.

By inhaler substrate 7 sealings, this substrate is formed for the opposite face 5 of the actuating of inhaler 1 to this circle-columniform inhaler shell 6 in the bottom.Towards a side relative with this substrate 7, this shell 2 is the forms of opening wide.

In the bottom section of shell 2, the mouth of pipe 3 extends from shell 2 along general radial direction, for example in the exemplary embodiment that illustrates, the acute angle that has about 75 to 80 degree more definitely with respect to inhaler axis x, this mouth of pipe roughly forms hollow cylindrical body, and opening is with respect to the outside axially facing in the location of the mouth of pipe 3.Mouth of pipe substrate 8 is arranged on from shell 2 to the mouth of pipe 3 the transitional region, and this mouth of pipe substrate has central opening 9.

Axially spaced-apart place at this center substrate opening 9, air inlet opening 10 forms in mouth of pipe wall along circumference, this air inlet opening 10 is provided with in equally distributed mode, and the inner space that is used for the mouth of pipe that is associated with substrate opening 9 is connected to the air-flow of surrounding.

When not using inhaler 1, be stamped nut 11 above the mouth of pipe 3.For this purpose, the mouth of pipe 3 externally sidewall is provided with external screw thread 12, and the female thread 13 of this external screw thread and medicated cap 11 interacts.The side direction part that comprises female thread 13 of nut 11 on the closed position is engaged in the air inlet opening 10 of the mouth of pipe 3, the annular end face of this side direction part of nut 11 also in the mode of block restriction (stop-limited) against housing parts.

Shell 2 is laterally divided by bearing 14 with respect to housing axis x, and this bearing 14 is in that 3 transition level face is fixed on the inwall of shell from shell to the mouth of pipe.Thereby obtain with respect to the shell upper branch of bearing 14 and the lower part that is associated with opposite face 5, heart is passed through in the supported pipe 15 in described lower part, and this stay pipe in axial direction extends and this bearing 14 is positioned at this above stay pipe.Hygroscopic material 16 is contained in the annular space that produces in the lower casing part thus.In addition, this annular space 17 is communicated with the cylindrical interior space of the mouth of pipe 3 via additional flow openings 18, and is communicated with surrounding via air inlet opening 10, and this additional flow openings forms in the zone of mouth of pipe substrate 8.

The solid bearing 14 of this plate-like has center consent 19, and the sealing member 20 that is made of thermoplastic is installed in this consent.Sealing part 20 is arranged in consent 19 in the mode of connector, and bearing 14 also is supported on by means of sealing part 20 on the pipe 15.

Sealing part 20 is provided with gas channel 21, and this gas channel is roughly aimed at as the crow flies and intersected about axis x, and this gas channel all continue on both sides, passes through bearing 14 respectively.Therefore gas channel 21 extends on a side of sealing member 20, makes this gas channel by the central opening 9 of bearing 14 as far as mouth of pipe substrate 8, to form air outlet slit 22.Along with respect to the relative direction of sealing member 20, gas channel 21 is extended to the top of being blocked by bearing 14 of shell, and has the cross section of widening.Corresponding access portal 23 forms on divide in the face of shell upper wide of bearing 14, and this access portal 23 is also covered by filter cell 24.

Therefore this gas channel 21 is divided into the channel part of mouth of pipe side and the part of shell side.In the part of shell side, form the access portal 23 that is coated with filter.Replenish flow openings 25 and also be arranged in this part, this additional flow openings and access portal 23 are oppositely arranged, and the connection of formation gas channel 21 between the part of shell side and the annular space 17 that forms below bearing 14.Should replenish above the flow openings 25 and covered by air intake valve 26, this air intake valve is provided with in this way, makes that replenishing flow openings 25 only opens under the situation of direction by gas channel 21 that the air-flow from annular space 17 divides along shell upper.Along the rightabout of air-flow, valve 26 cuts out this additional flow openings 25.

To compare gas channel 21 very little with the free cross section of the mouth of pipe 3, particularly in the zone of the part of the regional neutral plane line up 3 of sealing member 20.For example, the free diameter of the inner space of the mouth of pipe 3 approximately corresponding to ten times of the diameter of gas channel 21 to thirtyfold, this gas channel forms in tapered mode in the zone of the downward extension that tilts, the direction of the opening along mouth of pipe side 9 from sealing member 20 particularly is to form the passage of nozzle-like.

Sealing member 20 usefulness same materials are combined into funnelform locker room 27 with the form of single-piece, and this locker room divides in the face of shell upper and has the cross section of upwards widening, and that is to say the direction of opening wide at end face along shell.Storage locular wall 28 correspondingly also is made of the material of thermoplastic elastomer (TPE) or other rubber like.

The free end of the widened diameter of locker room 27 is kept by keeper 29, this locker room is with respect to inhaler axis x lateral alignment, and be fixed to bearing 14 by means of support member 30, the lower end of this bearing sealed storage chamber 27, these support members extend to the sidepiece of locker room 27, and are provided with relative to each other.Axial distance between the end of locker room correspondingly is fixed.

The last free end of locker room 27 remains in the keeper 29 in the mode of sealing, for example is clipped in outwards retaining ring 31 and radially in the connector shape between the retaining part 32 of footpath in the exemplary embodiment that illustrates.

Micronized powdered rubber 33 remains in the locker room 27, and this powdered rubber plans to be inhaled in the mode that is assigned with discharging by means of described device.

The discharging that is assigned with for material 33 is provided with dosage chamber 34, has for example illustrated three in first embodiment.The size of each dosage chamber 34 define separately with the amount of substance that is transferred.

Dosage chamber 34 forms the cross-drilled hole 35 of bar 36, and this bar 36 forms flat bar and extends along axis x center.At this, cross-drilled hole 35 passes the broad side walls surface of flat rod 36, and it is 1: 5 to 1: 20 cross section that this flat rod has the width/height ratio.In the exemplary embodiment that illustrates, the thickness of flat rod is chosen as about 0.5mm, and the length of cross measure is approximately 3 to 3.5mm.The selection of the diameter of cross-drilled hole 35 makes the dosage chamber 34 that forms thus receive separately from the material of 0.05mg to 0.1mg dosage.

Bar 36 with dosage chamber 34 along the ground, bearing of trend center of axis x through locker room 27.27 the bottom in the locker room, bar 36 also passes sealing member 20, intersects with the gas channel 21 that forms in sealing member simultaneously; Because this structure, closing at first of gas channel 21 realizes by means of bar 36.

In opposite direction, bar 36 extends beyond locker room 27, passes the keeper 29 that limits locker room 27 simultaneously.Being arranged in the zone that bar 36 passes keeper 29 is other sealing member 37, and this sealing member 20 that is similar in the bottom section of locker room 27 acts on the surface of bar 36 in the mode of CONTACT WITH FRICTION, seals the zone of being passed simultaneously.

In initial position according to the inhaler shown in Fig. 11, dosage chamber 34 adjoining land settings and relative to each other evenly spaced apart along the longitudinal extent of bar 36, these dosage chambers are positioned in the following three/part by material 33 encirclements of storing of locker room 27.

Interval each other, dosage chamber 34 is roughly corresponding to the diameter of the cross-drilled hole 35 that forms dosage chamber 34.

The free end that projects upwards 27 tops, locker room of bar 36 is provided with the driver 38 of similar mushroom head.This driver is kept by rake arm (drag arm) 39, these rake arm formation below actuation button 4, and the length that has is probably corresponding to the twice of driver 38 along the length of axis x scope direction.In this way, driver 38 in the face of the top of actuation button 4 and drive surface 40 between produce invalid dislocation, this drive surface 40 is corresponding to the top and below actuation button 4.

Actuation button 4 is substantially transversely extended with respect to inhaler axis x, and this actuation button 4 is attached in the cylindrical part that forms with one heart with respect to axis x, and has cup-shaped wall 41, and this cup-shaped wall enters shell 2, and its Open Side Down faces.The external diameter of this wall 41 correspondingly is suitable for the internal diameter of the cylindrical part 6 of shell.Actuation button 4 can be pushed in the shell 2, and its wall 41 is by cylindrical part 6 guiding, and this has the block restriction in end separately.

In order to realize this block restriction, the cylindrical part 6 of shell has two radially relative guide humps of radially inwardly facing 42 in the zone of its free periphery, cooperate in the axially parallel groove 43 of this guide hump in the zone of the outside lateral surface of wall 41.This has also realized preventing the effect of shell 2 with respect to actuation button 4 distortions.

In the free end of the wall 41 of actuation button was projected into zone in the shell 23, annular recess 44 was arranged on the outside lateral sidewall, is used to hold the piston ring 45 that is made of elastomeric material, for the inwall of this piston ring of sealing purpose against the cylindrical part 6 of shell.

Spiral back-moving spring 46 helps the initial position of maintenance according to the actuation button shown in Fig. 1, this action of reset spring is below actuation button 4, center on the rake arm 39 of bar 36 and actuation button 4 simultaneously, this back-moving spring 46 is supported on the other end of keeper 29, and this keeper forms the terminal at the head place of locker room 27.This initial position limits by the lower end that guide hump 42 is resisted against the groove 43 on the actuation button, and the driver 38 on this initial position king-rod also presents the ultimate range from the drive surface 40 of actuation button 4.

Wedge shape breaks away from the dislocation path of wall 41 that ridge 47 extends to actuation button, has the right upward continuous inclined-plane 61 of two radially relative arms 49, these arms in the free end zone in the bottom the inside outstanding thrust piece (thrust piece) 48 of carrying radially.Be provided with support member 30 location of these arms 49 of thrust piece 48, make that their skews 90 are spent in vertical view with respect to carrying holder 29; These arms also are fixed on the support member by means of the bearing on the keeper 2, and this keeper 29 is the form of circular rings in vertical view.Arm 49 and thrust piece 48 be formed on the jaw 60 that extends in the vertical view radially inwardly towards projecting surface 50, or in the cross section that passes inhaler 1, be parallel to the broad side surface and a segment distance with interval of bar 36.Correspondingly, projecting surface 50 is located such that they face the broad side surface of bar 36, and these projecting surfaces 50 also form in planar mode respectively.

Especially, the hinge area 51 on the bearing of these arms 49 and particularly circular rings form is selected with respect to material and/or is selected with respect to material thickness, radially inwardly pivots around the direction of hinge area 51 along axis x with permission.The elastic characteristic of selecteed plastic material is used for arm 49 and automatically returns to the home position.

Arm 49 in axial direction length measured is selected, makes to be arranged on probably 27 following 1/3rd the horizontal plane place extension of locating the end in the locker room of thrust piece 48.

The function of inhaler 1 is as follows:

Give actuation button 4 by exert pressure (representing with arrow P), actuation button drops in the shell 2 in the allochthonous mode of sliding along axis x.Because by means of the sealing of piston ring 45, shell 2 and cup-shaped actuation button 4 form compressed air cylinder D, in this cylinder D,, actuation button 4 produces positive air pressure owing to reducing.At this, the inner downside that is positioned at of actuation button 4 forms piston area.

In addition, during the moving downward of actuation button 4, break away from protrusion 47 in case by means of the edge of the end of wall 41 just working, the end face of this wall 41 is provided with corresponding inclined-plane, when button 4 further descended, this inclined-plane lead arm 49 inwardly pivoted around hinge area 51.The radius that winds with respect to hinge area 51 of thrust piece 48 inwardly pivots thus, and storage locular wall 28 flexes inward into according to the filling position B shown in Fig. 2, projecting surface 50 alignings parallel to each other wherein, and broad side surface parallel alignment with bar 36, in this position, the part separately of storage locular wall is positioned at wherein, and a part of material is pressed in the dosage chamber 34.In the initial position of inhaler 1, the material that occurs on the both sides of dosage chamber opening is forced in the cross-drilled hole 35 by means of storage locular wall 28 and the thrust piece 48 that acts on this storage locular wall, after this material is held consistent with himself in dosage chamber 34, particularly under the situation of micronized powdered rubber.

Curving inwardly of storage locular wall 28 is used for pressurizing medium enters into dosage chamber 34, the help of the positive air pressure among the compressed air cylinder D that this bending is subjected to producing during this process.

Bar 36 remains in its initial position, and by complete filling, this is attributable to the invalid dislocation that is provided with in the zone of rake arm 39 up to dosage chamber 34.Only after this of dosage chamber filled, the drive surface 40 that forms below button is resisted against the driver 38 on the end of bar, with the further dislocation drag strut 36 downwards along with actuation button 4.

Bar after fill the dosage chamber allochthonous downwards during, dosage chamber 34 adjoining lands and the gas channel 21 of filling are in line, and are after this closed this feasible possible build-up pressure by the solid end of the sealing of bar 36 in the mode of similar slip up to this gas channel.When dosage chamber 34 arrives gas channel 21 (evacuate position E), the valve of Chan Shenging is temporarily opened in this way.The cross-drilled hole 35 that forms dosage chamber 34 becomes the part of gas channel 21.The material that the positive air pressure of setting up causes distributing is suddenly blown out from the dosage chamber, and via air outlet slit 22 this part is injected in the mouth of pipe 3, this mouth of pipe is centered on by antelabium in the mode that air inlet opening 10 is uncovered between the period of energization of inhaler 1.By sucking, surrounding air is inhaled into via these air inlet openings 10, and is supplemented with the material that a slice of injection is assigned with.

In the corresponding modes of configuration that are provided with three dosage chamber 34 adjoining lands shown in the exemplary embodiment, material part is discharged very apace, and the downward allochthonous speed that depends on actuation button 4, material part advance a period of time by compressed air respectively.

During downward dislocation, the free end that in axial direction extends downwards of bar 36 enters into the inner space of stay pipe 15.

The terminal position that the downward allochthonous direction in the edge of actuation button 4 is observed is similarly limited by block.This is to work against the last outer regions with their interactional grooves 43 by guide hump 42, and/or the free annular end face of the wall 41 by actuation button works against the surface of bearing 14.

By exerting pressure no longer for actuation button 4, because the spring force that produces, actuation button 4 will automatically turn back to initial position with towed bar 36.This is accompanied by the arm 49 that comprises thrust piece 48 and is released, because the elastic characteristic of selecteed material, these arms also correspondingly are pivoted back to their home position.

Actuation button 4 return during the dislocation and follow the volume of compressed air cylinder D become big during, the air that replenishes is inhaled into.This is via additional flow openings 18 and 25 and produce, and when air intake valve 26 was correspondingly opened, additional air flow through hygroscopic material 16.

Because the funnel shaped structure of locker room 7, when no longer applying the external loading that acts on the storage locular wall 28 by means of thrust piece 48, material is automatically replenished by the raw material to lower slider, this the replenishing of material also helped by bending, and this bending is produced by the 28 aduncate influences of storage locular wall.

Except element and locker room 27 with sealing characteristics, and selectively except the element that comprises thrust piece 48 with elastic characteristic and arm 49, inhaler 1 is by the plastic material manufacturing, the keeper 29 of more particularly using rigid plastic material manufacturing, particularly shell and having the actuation button 4 of wall 41 and have bearing 14.Bar 36 also can be by this rigid plastic material manufacturing.Yet the bar 36 of metal material is preferred in this respect.

In addition, be designed for mouthful also can being expected being used for the embodiment that snuffing goes into the inhaler 1 for the treatment of, for example shown in Figure 12.

According to shown in Figure 12, be used for the embodiment that snuffing is gone into, outflow or discharging area directly are inclined upwardly with respect to vertical axis x, therefore comprise with respect to the angle of longitudinal axis to about 45 degree of x.For this purpose, shell 2 is provided with nasal tube 65, and when when not using inhaler 1 corresponding to the mode of the described embodiment of pro-, the top of this nasal tube covers with nut 11.

This nasal tube 65 is suitable for being introduced in the nostril on its longitudinal extension and its external diameter.On the longitudinal extension of nasal tube 65, heart is passed nasal tube 65 in the discharge-channel 66.The end channel part 67 of gas channel 21 launches to enter into discharge-channel 66, the free end 68 of gas channel 21 is placed with respect to the free end 69 of nasal tube 65, make free end 68 step back setting, correspondingly axially step back setting with respect to the axis of the main body of nasal tube.

With with the corresponding mode of aiming at of nasal tube 65 or its main body axis, promptly acutangulate aligning with respect to longitudinal axis x, end channel part 67 is also extended, make it be directed being inclined upwardly from the straight gas channel 21 of guiding with crossing, while is with respect to the cross section of gas channel 21, it is about 1/3rd that free cross section reduces, and this allows the structure of the nozzle-like of end channel part 67.

Arrange end channel part 67 and nasal tube 65 by the mode that is directed to be inclined upwardly with respect to housing axis x, with and make the shell 2 of inhaler 1 aim at along approximately perpendicular housing axis x on the whole, can realize that being used for snuffing goes into.

Second embodiment has been shown in Figure 10 and 11, has been used to have the inhaler 1 that dosage is provided with.

Ring-type setting device 52 is arranged in the face of centering on shell 2 in the last outer regions of actuation button 4.Described device be provided with the ring 62 can with respect to axis x around this axle coaxially progressively the rotation, for example be used to be provided with five kinds of different dosages through four spin locking stages.

On interior side direction surface, ring-type setting device 52 is provided with stepped main body 53, and these stepped main bodys are provided with in the relative mode in diameter ground, and is formed and makes them with the window 54 of radially inwardly outstanding mode by shell 2.

Each stepped main body 53 is provided with composition surface 55, relative to each other setovers in fractionated mode in these composition surfaces.The quantity of step surface is provided with the quantity of probability corresponding to dosage.These composition surfaces 55 interact with projection 56, and this projection 56 is arranged on the outer lateral surface of wall 41 in relative mode on the diameter correspondingly.Be directed in the corresponding localized groove 57 of these projectioies on the inboard of the wall of the cylindrical part 6 of shell, and be prevented from respect to shell 2 distortions.

In case activate, be directed downwards the composition surface 55 of the crowning 58 the faced stepped main body 53 in the dislocation path that turns to projection 56 along pushing of actuation button 4, thus the motion of the dislocation of block actuation button 4.

This also can realize by the dislocation of bar 36, this bar 36 is provided with the dosage chamber 34 of five arranged in succession in this exemplary embodiment, and limited by block, therefore depending on the setting that engages by classification, the quantity that can be introduced in the dosage chamber 34 of evacuate position E can be selected in advance.

With with the corresponding mode of selection in advance by setting device 52, for example only two dosage chambers 34 or only the first dosage chamber 34 can be connected to gas channel 21, and when inhaler 1 activates, be blown by applying compressed air.In further being provided with, for example all dosage chambers 34 promptly in the illustrated embodiment five dosage chambers 34 can be incorporated into gas channel 21 by adjoining land, and their material part is discharged from as salvo.

Figure 13 to 19 shows the inhaler 1 among the embodiment again, and this inhaler is at first according to forming as first embodiment of mouth with inhaler.Indexing means 70 is set up, and is used to write down and indicate the suction process of finishing.This indexing means 70 is arranged in the actuation button 4 that is projected into shell 2 tops, so this indexing means also is positioned at the tight below at the top of actuation button 4, around with the driver 38 interactional rake arms 39 of bar 36.

This indexing means 70 probably comprises divided wheel 71 and calibration loop 72, and this calibration loop cooperates with divided wheel 71 reliable (positive).

Calibration loop 72 is provided with in the mode that sleeve is positioned at the tight below that activates the top, so this calibration loop is also concentric with respect to housing axis x.The peripheral wall of calibration loop be arranged on actuation button 4 wall 41 radially add alleviating distention in middle-JIAO, and correspondingly guarantee at this of wall 41 radially in the tank 73, rotate around housing axis x allowing.On outer lateral surface, calibration loop 72 is provided with scale 74, and this scale represents that no longer specifically for example this calibration loop has this scale that is printed thereon.This scale 64 can be in sight by window 75, and this window is arranged on from wall 41 to actuation button the wall of transitional region at 4 top.

On the interior side direction surface of calibration loop 72, the center of this ring on vertical length is provided with radially inwardly outstanding driving ridge 76.A plurality of this driving ridges 76 are set up, and for example its quantity is corresponding to the maximum quantity that suck to activate, and this ridge relative to each other keeps the interval that equates when considering on periphery.In the exemplary embodiment that illustrates, quite few quantity is selected on the other hand.At this, calibration loop 72 is driven in the mode that progressively reduces by means of ridge 76.

Divided wheel 71 interacts with the driving ridge 76 that these are in the reliable fit mode, this divided wheel 71 rotatably moves around rotation axis y, this axis y laterally aims at respect to housing axis x, and this axis y extends in the plane that is limited by driving ridge 76.This axis y provides in structural relation by axial main body 77, and this axial main body 77 is maintained on the both sides at the place, end of hold-down arm 78, and this hold-down arm hangs downwards and inwardly gives prominence to from the top of actuation button.

Divided wheel 71 roughly forms single-start worm axle (worm shaft) 79, has spiral type pitch (volute pitch), and it along the circumferential direction is suitable for the interval of two adjacent driven ridges 76.When along its axial direction consideration, the length that this worm-wheel shaft 79 is provided with makes and obtain two to three spiral sections when considering substantially as integral body.The driving ridge 76 that each is associated enters between the spiral side at axial horizontal plane place of divided wheel 71.When worm-wheel shaft 79 during, correspondingly can produce maintained driving ridge 76 along continuous straight runs and also just say the dislocation horizontal with respect to housing axis x around axis y rotary setting.

The peripheral edge that extends around the end face of spiral section forms jagged profile, and each tooth 80 has precipitous side, and is probably directed on radius, and to it behind, shallow side drops to the tooth 80 that the next one follows closely.In the exemplary embodiment that illustrates, 9 teeth 80 are formed on the circumference in the cross section that passes divided wheel 71, described tooth is dimensioned and makes when laterally considering, just aim at axis y, the tooth 80 of a spiral section is in line on floor projection with the tooth 80 of adjacent spiral section.Thereby each flank of adjacent spiral section is also aimed in common plane.

Tooth 80 interacts with counting finger 81, when the rotation axis y that is parallel to divided wheel 71 considers, that is to say with divided wheel 71 interactional actuation ends parts 82 in, the width that this counting finger has in the free end zone is probably corresponding to the width of measuring along the equidirectional of divided wheel 71.

Counting finger 81 is fixed in the bearing of circular rings form, the arm 49 of this bearing carrying thrust piece 48, and the direction to upper edge divided wheel 71 is extended in the mode of bar, with housing axis x parallel alignment, in according to the initial position shown in Figure 13, counting finger 81 vertically be in divided wheel 71 at a distance of a segment distance, the actuation part of formerly describing that tapers off to a point 82 is located to form endways simultaneously.

The vertical dimension with between the steep sides that activated of the tooth of radially inwardly facing 80 of counting actuation part 82 of finger 81 and divided wheel 71 is selected, make this distance corresponding to the initial position of actuation button 4 from Figure 13 to the dislocation that enters into the crossover position of gas channel 21 according to Fig. 5 or medicine shown in Figure 6 from the dosage chamber 34 that is full of.Thereby, indexing means 70 only activated and that is to say the position of advancing, during the downward dislocation of actuation button 4, at first implement the filling of dosage chamber 34 by means of thrust piece 48, after this along with the further downward dislocation of actuation button 4, obtained to be used for the required air pressure that blows out of blowing out suddenly of dosage chamber 34.In the mode of describing, the further downward dislocation of actuation button 4 is incorporated into dosage chamber 34 in the zone of gas channel 21, owing to produce air pressure, material is by the circulation road 21 that puffs away suddenly.The further guiding vertically downward of button 4 activates dislocation and causes toothed portion of divided wheel 71 rotation dislocations.Be arranged on shallow vertical teeth side behind and make that actuation part 82 can landing when actuation button 4 dislocations are got back to initial position.Keep finger 83 outstanding from the top of actuation button 4 downwards, this maintenance finger and actuation part 82 are oppositely arranged, and work on tooth 80, prevent that divided wheel 71 from going back to, and be opposite with the allochthonous predetermined direction of counting.

The bioactive substance that inhaler can hold various medicines and/or be used to suck.

Any desired active treatment or diagnostic substances all can be selected as bioactive substance, for example the group that forms from following material comprises the anti-allergy material, the bronchiectasis material, bronchoconstrictor, the lung surface active substance, analgesic, antibiotic, leukotriene inhibitor or antagonistic, anticholinergic, the mastocyte inhibitor, hydryllin, antiinflammatory, antineoplastic agent, anesthetics (anasthetic), antitubercular agent, contrast agent, active cardiovascular material, enzyme, steroid, hereditary material, viral vector, antisense strand reagent, the combination of protein and peptide and these materials.

The example that can be filled into the concrete medicine in the inhaler according to the description of this patent is especially: mometasone, ipratropium bromide, tiotropium bromide and its esters, salmaterol, fluticasone propionate, beclomethasone, reproterol, Clenbuterol, rofleponide and its esters, nedocromil, sodium cromoglicate, flunisolide, budesonide, formoterol fumarate dihydrate, Symbicort

(budesonide and formoterol), terbutaline, terbutaline sulphate, albuterol and salbutamol sulfate, fenoterol, 3-[2-(4-hydroxyl-2-oxo-3H-1,3-benzothiazole-7-yl) ethylamino]-N-[2-[2-(4-aminomethyl phenyl) ethyoxyl] ethyl] third sulfonamide and hydrochlorate.According to pharmacy practice, all above-claimed cpds can be the form of free alkali (free basic) or the form of medicine salt.

The combination of medicine also can be used, for example formoterol/budesonide; Formoterol/fluticasone; Formoterol/mometasone; Salmaterol/fluticasone; Formoterol/tiotropium bromide salt; Zafirlukast/formoterol; Zafirlukast/budesonide; Montelukast/formoterol; Montelukast/budesonide; Loratadine/montelukast and loratadine/zafirlukast.

Possible in addition combination is particularly: tiotropium bromide and fluticasone; Tiotropium bromide and budesonide; Tiotropium bromide and mometasone; Mometasone and salmaterol; Formoterol and rofleponide; Salmaterol and budesonide; Salmaterol and rofleponide and tiotropium bromide and rofleponide.

All disclosed features all (fully) are related to the present invention.The disclosure of the priority document that is associated/attaches (copy of pro-patent application) is also introduced in the application open fully, comprises in order to merge the purpose of the feature of those files in the application's claim.

Claims (21)

1. one kind is used for the particularly inhaler (1) of the powdered rubber of medicine (33), described inhaler has material locker room (27) and dosage chamber (34), described dosage chamber receives the material of limited amount and forms the cross-drilled hole (35) of bar (36), and can be displaced to evacuate position (E) from filling position (B), in described evacuate position (E), described dosage chamber (34) is arranged in gas channel (21), it is characterized in that, to small part locker room wall (28) at described inhaler (1) direction dislocation along described bar (36) when activateding.

2. inhaler according to claim 1 is characterized in that, when described inhaler (1) when activateding, completely or partially the described storage locular wall (28) that is made of elastomeric material is bent along the direction of described bar (36).

3. according to aforementioned one or more claim or especially according to its described inhaler, it is characterized in that described storage locular wall (28) is bent at least in the zone in dosage hole, up to described storage locular wall (28) against described bar (36).

4. according to aforementioned one or more claim or especially according to its described inhaler, it is characterized in that curving inwardly is achieved or gets help by the air pressure pad that produces when described inhaler activated.

5. according to aforementioned one or more claim or especially according to its described inhaler, it is characterized in that thrust piece (48) is used for curving inwardly of described storage locular wall (28).

6. according to aforementioned one or more claim or especially according to its described inhaler, it is characterized in that, invalid dislocation between actuation button of described inhaler (4) and the described bar (36) makes: described bar (36) driven advance before, make described storage locular wall (28) curve inwardly by means of the thrust piece (48) of outside.

7. according to aforementioned one or more claim or especially according to its described inhaler, it is characterized in that, described thrust piece (48) is provided with jaw (60), described jaw (60) has composition surface (50), and described composition surface is parallel to described bar (36) in the complete pivot position of described thrust piece (48) broad side walls surface is provided with.

8. according to aforementioned one or more claim or especially according to its described inhaler, it is characterized in that, the actuation button (4) outstanding at the head place of the shell (2) of described inhaler can overcome back-moving spring (46) by dislocation, and after a bit of invalid dislocation, described actuation button promotes described bar (36) in the front of described bar, and by means of successive inclined-plane (61) described thrust piece (48) is pivoted along the direction of described bar (36).

9. according to aforementioned one or more claim or especially according to its described inhaler, it is characterized in that, produce positive air pressure by the dislocation of described actuation button (4) in the shell (2) of described inhaler, and then make described material (33) be blown into described gas channel (21) by the dislocation of described bar (36).

10. according to aforementioned one or more claim or especially according to its described inhaler, it is characterized in that, elastic piston ring (45) is in the inside stub area of the cup-shaped wall (41) of described actuation button (4), and the shell of described inhaler (2) and its inwall are formed for the pressure cylinder (D) of described piston ring (45).

11., it is characterized in that the cross section of described bar (36) is closed air outlet slit according to aforementioned one or more claim or especially according to its described inhaler.

12., it is characterized in that air intake valve (26) is positioned at air outlet slit pass close point and holds between the outer casing space of described locker room (27) according to aforementioned one or more claim or especially according to its described inhaler.

13., it is characterized in that setting device (52) is used for definite quantity that can be introduced in the dosage chamber (34) of described evacuate position (E) according to aforementioned one or more claim or especially according to its described inhaler.

14. one kind is used for the particularly inhaler (1) of the powdered rubber of medicine (33), described inhaler has material locker room (27) and dosage chamber (34), described dosage chamber receives the material of limited amount and forms the cross-drilled hole (35) of bar (36), and can be displaced to evacuate position (E) from filling position (B), in described evacuate position (E), described dosage chamber (34) is arranged in gas channel (21), it is characterized in that, described bar (36) has a plurality of adjoining lands and is positioned at dosage chamber (34) on the described bar (36), these dosage chambers adjoining land between the discharging period of energization moves to described evacuate position (E), and can be blown over by the positive air pressure in the described gas channel (21) one by one.

15., it is characterized in that described bar (36) forms flat rod according to claim 14 or especially according to its described inhaler.

16. according to aforementioned one or more claim or especially according to its described inhaler, it is characterized in that, ring (62) is set has a plurality of steps, be used in the dosage chamber (34) of specific quantity by described evacuate position (E) the dislocation motion of the described actuation button of block (4) afterwards.

17., it is characterized in that block projection (56) is positioned on the described actuation button (4) according to aforementioned one or more claim or especially according to its described inhaler.

18. according to aforementioned one or more claim or especially according to its described inhaler, it is characterized in that, the described gas channel (21) that directly crosses extends to the acclivitous end channel part (67) with littler cross section, described end channel partly ends in the nasal tube (65), makes described end channel part step back from the free end (69) of described nasal tube.

19. according to aforementioned one or more claim or especially according to its described inhaler, it is characterized in that,, activate indexing means (70) when reaching when blowing out air pressure.

20. according to aforementioned one or more claim or especially according to its described inhaler, it is characterized in that, counting finger (81) acts on the described indexing means (70), arrives divided wheel (71) when the tip (82) of described counting finger probably enters into the zone of described gas channel (21) in the dosage chamber (34) that is full of of described bar (36) dislocation begins.

21., it is characterized in that described divided wheel (71) rotates the calibration loop (72) of described indexing means (70) with the form of worm gear according to aforementioned one or more claim or especially according to its described inhaler.

Images