CN101401926B - Umbilicus-applied medicament for treating emesis of chemotherapy - Google Patents
Umbilicus-applied medicament for treating emesis of chemotherapy Download PDFInfo
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- CN101401926B CN101401926B CN2008101596793A CN200810159679A CN101401926B CN 101401926 B CN101401926 B CN 101401926B CN 2008101596793 A CN2008101596793 A CN 2008101596793A CN 200810159679 A CN200810159679 A CN 200810159679A CN 101401926 B CN101401926 B CN 101401926B
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Abstract
The invention discloses a cover-navel medicine for treating chemotherapy-induced nausea. The medicine comprises the following pharmacodynamic raw materials in portion by weight: 10 to 40 portions of Pinellia ternate, 10 to 20 portions of flos caryophylli, 10 to 30 portions of Evodia rutaecarpa and 10 to 30 portions of adequate ginger juice or dried ginger. The cover-navel medicine can be used for preventing and treating acute nausea, delayed nausea and predicted nausea due to chemotherapy, can also be used for treating nausea due to various other factors, and simultaneously can effectively treat abdominal distension, diarrhea and inappetence due to chemotherapy, and abdominal distension, constipation and diarrhea due to an antiemetic Western medicine.
Description
One, technical field
The invention belongs to the field of Chinese medicines, particularly a kind of cover-navel medicine of vomitting due to the chemotherapy that is applicable to.
Two, background technology
Chemotherapy is one of tumor three big Therapeutic Method, but the caused untoward reaction of chemotherapy has caused great misery to the patient, and nausea and vomiting is one of its topmost untoward reaction.This reaction has greatly influenced patient's quality of life, has increased the difficulty of its follow-up chemotherapy, is the major obstacle that the patient tolerates chemotherapy.How to control the vomiting reaction that chemotherapy causes, become the focus of attention of clinical research gradually.The 5-HT3 antagonist becomes the important adjuvant drug of chemotherapy, but the 5-HT3 antagonist can produce side reactions such as headache, dizziness, weak, constipation, diarrhoea, and invalid to tardive vomiting; NK1 receptor antagonist (aprepitant) is though share the vomiting of tardy property effectively with corticosteroid hormone, and the former costs an arm and a leg, and many poor patients are difficult to accept; Oral preparation of Chinese traditional medicinal can't be taken because of patient's vomiting.
Three, summary of the invention
The objective of the invention is deficiency at above-mentioned existing chemotherapy antiemetic, a kind of instant effect, evident in efficacy, simple for production, cheap, the umbilical external application medicine that is used for the treatment of emesis of chemotherapy that has no side effect are provided, the vomiting reaction that causes because of other reasons is also had certain curative effect.
Technical scheme of the present invention is as follows:
Cover-navel medicine of the present invention is mainly made by the pharmacodynamic raw materials of following weight proportion:
10～30 parts of 10～40 parts of the Rhizoma Pinelliaes, 10～20 parts of Flos Caryophyllis, 10～30 parts of Fructus Evodiaes, an amount of extracting juice of Rhizoma Zingiberis Recens or Rhizoma Zingiberiss.
Each component preferred weight part ratio of the present invention is:
30 parts of 40 parts of the Rhizoma Pinelliaes, 20 parts of Flos Caryophyllis, 30 parts of Fructus Evodiaes, an amount of extracting juice of Rhizoma Zingiberis Recens or Rhizoma Zingiberiss.
Above-mentioned each component pharmacological action is analyzed
1. the Rhizoma Pinelliae
Is the Rhizoma Pinelliae in the said cover-navel medicine of the present invention preferably selected Rhizoma Pinelliae (reason for use?), also can select Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) or Rhizoma Pinelliae Preparatum for use.The hot temperature of the Rhizoma Pinelliae is gone into spleen, stomach, lung meridian." the spleen being the source of producing phlegm ", go into the spleen drying dampness to eliminate phlegm radically reform with remove vomiting because of; Go into the stomach stopping nausea and vomiting by lowering the adverse flow of QI,, tell key medicine for stopping vomiting since ancient times to treat the disease of vomiting.The Zhang Zhongjing stopping vomiting is told all sides, as Small Pinelliae Decoction, the little Rhizoma Pinelliae add Poria soup, big Rhizoma Pinelliae soup etc. all be monarch drug." property of medicine opinion " carries its energy " appetite promoting and the spleen strengthening, preventing or arresting vomiting is told ", and " Bencao Congxin " carries its " stomach function regulating spleen invigorating, dehumidifying is reduced phlegm ... subinverse gas, ends tired vomitting ".According to modern pharmacological research, this product contains cupreol and glycoside, several amino acids and volatile oil, and Saponin, the acidity alcohols, choline, alkaloid such as sanedrine and little fat, starch etc. can suppress vomiting center and preventing or arresting vomiting.
2. Flos Caryophylli
The hot temperature of Flos Caryophylli is returned spleen, stomach, lung, kidney channel, effect warming middle-JIAO to send down the adverse QI, dispersing cold for relieving pain, warming the kidney to activate YANG, the stomachache that treatment causes because of Deficiency and coldness of spleen and stomach, diarrhoea, vomiting etc.According to modern pharmacological research, this product contains volatile oil, and main component is eugenol, acetyleugenol, β-caryophyllene etc. in the oil, can promote gastric secretion, strengthen eupepsy, alleviate nausea and vomiting, alleviate abdominal bloating, be aromatic stomachic, and eugenol has the local anesthesia analgesic effect.
3. Fructus Evodiae
Fructus Evodiae suffering, hardship, heat is returned liver, spleen, stomach, kidney channel, has dispersing cold for relieving pain, warming middle-JIAO to arrest vomiting, the effect of supporing yang antidiarrheal,, be used for the vomiting and diarrhoea of Deficiency and coldness of spleen and stomach; This product contains volatile oil, and main component is evodene, ocimene, obaculactone, evodol etc. in the oil, still contains multiple alkaloids such as xanthoxylic acid, evodine and rutaecarpin, rutaecarpine in addition, have the town tell, analgesic activity.
4. Rhizoma Zingiberis Recens
The Rhizoma Zingiberis Recens suffering, temperature.Return lung, spleen, stomach warp, relieving the exterior syndrome by diaphoresis is arranged, warming middle-JIAO to arrest vomiting, the effect of warming the lung to relieve cough is apt to control the cough due to wind and cold, goes into stomach through being apt to warming middle-JIAO to arrest vomiting again, and vomiting is planted by Zhiduo County.Pharmacological research this product contains volatile oil, be mainly zingiberol, zingiberene, phellandrene, citral, aromatic alcohol, methyl heptenone, aldehyde C-9, α-Borneolum Syntheticum etc. in the oil, still contain the pungency component gingerol, can secrete by facilitating digestion liquid, the effect of the diet of enhancement is arranged, and have that tell in the town, analgesia, resist inflammation on repercussive function, and the easier absorption of Rhizoma Zingiberis Recens extracting juice umbilical part.
4 herbal medicines of the present invention all have the effect of warming middle-JIAO to send down the adverse QI preventing or arresting vomiting, the wherein Rhizoma Pinelliae and Rhizoma Zingiberis Recens compatibility, i.e. Small Pinelliae Decoction, Rhizoma Zingiberis Recens except that assisting Rhizoma Pinelliae warming middle-JIAO to send down the adverse QI preventing or arresting vomiting, the effect of separating Rhizoma Pinelliae poison in addition; Fructus Evodiae, the hot perfume of Flos Caryophylli contain volatile oil, except that the antiemetic effect that strengthens Small Pinelliae Decoction, can promote that again medicine absorbs by umbilical part.Umbilicus is a SHENQUE acupoint, has another name called Qishe, can rise to fall, reinforce insufficiency and reduce excessiveness, the logical Yuanyang of temperature, Soviet Union faints and takes off admittedly, fortune gastrointestinal mechanism of qi, change functions such as cold-damp stagnates, medicine applies umbilicus, except that medicine effect itself, also can pass through " medicine gas " and the medicine stimulation inducing function to the acupuncture point, transfer the function of acupuncture point passages through which vital energy circulates, reached the purpose of curing the disease.Angle from modern medicine: umbilicus is that stomach wall is last closed in embryo development procedure, and skin is the thinnest, and the epidermis cutin is also the thinnest, and barrier function is the most weak, the easiest the penetrating of drug volatilization sexual element; Umbilicus is subcutaneous not to have fatty tissue, and peritoneum has abundant venous rete under the umbilicus, and the tremulous pulse subbranch is arranged, and neural blood vessel is abundant, and external used medicine more easily absorbs, and can enter blood circulation rapidly; Umbilical part is recessed to form crypts, forms the closure state of nature behind the medicament plaster, and medicine is able to the long period and deposits.According to clinical observation, the present invention except that having better antiemetic effect, regulate the flow of vital energy in addition remove to expand, relieving constipation, antidiarrheal etc. are to the dual regulation of gastrointestinal function, eliminate effectively or alleviated the gastrointestinal symptom that chemotherapy causes.Use medicine of the present invention to apply umbilicus, can adopt preceding 3 kinds of medicines to grind to the powder, an amount of accent of Rhizoma Zingiberis Recens extracting juice applied medical waterproof paster of adhesive plaster or 3M or SHANGSHI ZHITONG GAO external application; Also Rhizoma Zingiberis Recens can be changed into Rhizoma Zingiberis and make vaseline or Semen Ricini ointment, traditional black plaster or other patches (as the analgesic ointment agent), all belong within protection scope of the present invention.
The present invention is the inventor through prolonged and repeated test, grope, sum up and form, except that being used to prevent and treat acute vomiting, delayed vomiting and the prospective vomiting that chemotherapy causes, also can be used for the vomiting due to other a variety of causes, can also effectively treat abdominal distention, constipation, diarrhoea that abdominal distention, diarrhoea, inappetence and Western medicine antiemetic that chemotherapy causes cause simultaneously.Instant effect of the present invention (1～2 hour can take effect), curative effect height (total effective rate 97.3%) have no side effect, and be cheap, and preparation is simple, is convenient to clinical practice and popularization.
From year June in October, 2006 to 2008, the inventor applies the present invention to various chemotherapy of tumors vomiting sickness human therapies in Tai tumour hospital and tests 163 examples, divide 3 groups to carry out clinical observation: A group (acute vomiting group) and B group (delayed vomiting group), use the antiemetic prevention of emesis according to " American Society of Clinical Oncology's tumor patient Bendectin application guide in 2006 " routine before the chemotherapy, still occur the vomiter behind the treatment with chemotherapy medicine in 24 hours, give " subsides of emesis umbilicus " and apply 2 hours observe the curative effect behind umbilicus; C organizes (prospective vomiting group): promptly the vomiter still occurs according to " American Society of Clinical Oncology's tumor patient Bendectin application guide in 2006 " conventional patient who uses the antiemetic prevention of emesis, gave " subsides of emesis umbilicus " prevention of emesis in preceding 1 hour in the next cycle chemotherapy, 24 hours observe the curative effect behind the end of chemotherapy, the result sees table 1 for details:
Each group of table 1 is observed case load and effective percentage example (%)
More than observe and to have illustrated that the present invention is to the obstinate vomit determined curative effect due to the chemotherapy, also find to strengthen after using emesis umbilicus of the present invention pastes patient's appetite simultaneously, alleviate or eliminate the symptoms such as abdominal distention, constipation or diarrhoea that Bendectins such as granisetron cause, make patient accept chemotherapy smoothly.The abdominal distention that some other reasonses are caused, vomiting, constipation or diarrhoea are used the present invention's treatment simultaneously, have all obtained better curative effect, and this excludes range of observation.In the process of clinical application of the present invention, do not finish the treatment except that the slight abnormal smells from the patient irritated, that 1 example is disliked medicine of 2 routine local skins, all the other do not see any untoward reaction.
(3) preparation and using method
Take by weighing high-quality raw material according to above-mentioned each amounts of components, mix homogeneously after first three kind medicine is dried pulverizing respectively and crossed 80～100 mesh sieves, it is standby to bottle; The Rhizoma Zingiberis Recens chopping strand juice aseptic bottle of packing into is standby.Time spent earlier disinfects umbilical part in alcohol, and 3～5 parts in the powder of getting it filled spreads on umbilical part with the unguentum of an amount of furnishing soft or hard of Sucus Zingberis appropriateness, covers with the medical waterproof paster of 3M.
Four, the specific embodiment
Embodiment 1
Take by weighing raw material according to the following weight proportioning:
40 parts of the Rhizoma Pinelliaes, 20 parts of Flos Caryophyllis, 30 parts of Fructus Evodiaes, an amount of extracting juice of Rhizoma Zingiberis Recens.
Preparation method: first three is planted medicine dry respectively and pulverize and cross mix homogeneously behind 80～100 mesh sieves, it is standby bottle, and it is standby that the aseptic bottle of packing into behind the juice is twisted in the chopping of high-quality Rhizoma Zingiberis Recens.Time spent earlier disinfects umbilical part in alcohol, and the powder 3-5 part of getting it filled spreads on umbilical part with the unguentum of an amount of furnishing soft or hard of Sucus Zingberis appropriateness, covers with the medical waterproof paster of 3M.
Embodiment 2
Take by weighing raw material according to the following weight proportioning:
10 parts of the Rhizoma Pinelliaes, 15 parts of Flos Caryophyllis, 10 parts of Fructus Evodiaes, 30 parts of Rhizoma Zingiberiss.
Preparation method: above-mentioned each component oven dry is pulverized, and mix homogeneously is standby behind 80～100 mesh sieves excessively.Earlier Oleum Ricini or vaseline are put into canister in right amount, be heated to after the crack or vaseline of Oleum Ricini dissolves, slowly put into medicated powder, and constantly stir, treat to continue to boil after medicine is all put into after 3～5 minutes to take out, cool off standby.During application with 5～8 parts of deposited umbilicuss of ointment, the medical waterproof paster external application of adhesive plaster or 3M.
Embodiment 3
30 parts of the Rhizoma Pinelliaes, 10 parts of Flos Caryophyllis, 15 parts of Fructus Evodiaes, 20 parts of Rhizoma Zingiberiss.
Take by weighing raw material by weight ratio with embodiment 2, make the analgesic ointment agent, easy to use, do not affect the treatment, be convenient to store and produce in batches.
Embodiment 4
20 parts of the Rhizoma Pinelliaes, 18 parts of Flos Caryophyllis, 20 parts of Fructus Evodiaes, 10 parts of Rhizoma Zingiberiss.
Preparation method is with embodiment 2.
Embodiment 5
20 parts of the Rhizoma Pinelliaes, 18 parts of Flos Caryophyllis, 20 parts of Fructus Evodiaes.
Preparation method is with embodiment 1.
Claims (2)
1. cover-navel medicine that is used for the treatment of emesis of chemotherapy, it is characterized in that: described medicine is made by the pharmacodynamic raw materials of following weight proportion:
10～30 parts of 10～40 parts of the Rhizoma Pinelliaes, 10～20 parts of Flos Caryophyllis, 10～30 parts of Fructus Evodiaes, an amount of extracting juice of Rhizoma Zingiberis Recens or Rhizoma Zingiberiss.
2. the cover-navel medicine that is used for the treatment of emesis of chemotherapy according to claim 1 is characterized in that: described medicine is made by the pharmacodynamic raw materials of following weight proportion:
30 parts of 40 parts of the Rhizoma Pinelliaes, 20 parts of Flos Caryophyllis, 30 parts of Fructus Evodiaes, an amount of extracting juice of Rhizoma Zingiberis Recens or Rhizoma Zingiberiss.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2008101596793A CN101401926B (en) | 2008-11-11 | 2008-11-11 | Umbilicus-applied medicament for treating emesis of chemotherapy |
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| CN2008101596793A CN101401926B (en) | 2008-11-11 | 2008-11-11 | Umbilicus-applied medicament for treating emesis of chemotherapy |
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| CN101401926A CN101401926A (en) | 2009-04-08 |
| CN101401926B true CN101401926B (en) | 2011-11-02 |
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Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102091314B (en) * | 2011-03-02 | 2012-05-23 | 青岛大学 | Composition of dried ginger and evodia rutaecarpa, preparation method thereof and application thereof in preparing attenuating synergistic medicament in radiotherapy and chemotherapy of cancer |
| CN106421709A (en) * | 2016-11-10 | 2017-02-22 | 马玉珍 | Medicine for treating nausea and vomiting in pregnancy |
| CN109316540A (en) * | 2017-07-31 | 2019-02-12 | 吴冰 | A kind of strengthening the spleen and stomach acupoint plaster and preparation method thereof |
| CN107496863A (en) * | 2017-08-29 | 2017-12-22 | 四川省肿瘤医院 | Antiemetic pastes |
| CN108355029A (en) * | 2018-05-19 | 2018-08-03 | 华佑众生(北京)医疗科技有限公司 | It is a kind of to treat the drug and preparation method thereof vomitted after chemicotherapy |
| CN110354242A (en) * | 2019-08-16 | 2019-10-22 | 上海中医药大学附属岳阳中西医结合医院 | A kind of traditional Chinese medicine acupoint application, preparation method and applications for treating breast cancer |
| CN110368440A (en) * | 2019-09-03 | 2019-10-25 | 德州联合医院 | Alleviate the Chinese medicine composition and preparation method thereof of side effect of digestive tract |
| CN111467461A (en) * | 2020-04-17 | 2020-07-31 | 南京市中西医结合医院 | Acupoint application medicine for treating postoperative nausea and vomiting and using method thereof |
| CN111494595A (en) * | 2020-04-30 | 2020-08-07 | 江苏省肿瘤医院 | Externally applied adhesive plaster for lowering adverse qi and stopping vomiting and preparation method thereof |
| CN114984172B (en) * | 2021-03-01 | 2023-04-28 | 中国人民解放军海军军医大学第一附属医院 | Anti-emetic traditional Chinese medicine composition for external application, preparation method and anti-emetic binding belt |
| CN113827695A (en) * | 2021-11-08 | 2021-12-24 | 孟永斌 | Traditional Chinese medicine for warming middle energizer and stopping vomiting and treating nausea and vomiting caused by chemotherapy and preparation method thereof |
Citations (1)
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| CN1876163A (en) * | 2006-04-21 | 2006-12-13 | 张士舜 | Navel-adhibitting medicine for vomit-stopping in chemotherapy |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1876163A (en) * | 2006-04-21 | 2006-12-13 | 张士舜 | Navel-adhibitting medicine for vomit-stopping in chemotherapy |
Non-Patent Citations (1)
| Title |
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| 谢文英,等.吴茱萸.《异病同治临证经验集萃-162味中药的奇方妙用》.第二军医大学出版社,2007,(第1版),360-361. * |
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