CN101401644A - Medicament composition for preventing birth-defect and improving memory - Google Patents
Medicament composition for preventing birth-defect and improving memory Download PDFInfo
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- CN101401644A CN101401644A CNA200810223831XA CN200810223831A CN101401644A CN 101401644 A CN101401644 A CN 101401644A CN A200810223831X A CNA200810223831X A CN A200810223831XA CN 200810223831 A CN200810223831 A CN 200810223831A CN 101401644 A CN101401644 A CN 101401644A
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Abstract
The invention relates to a medical composition for preventing birth defects and improving memory, which comprises Langehead Atractylodes Rhizome, dogwood, vitamin B complex, and trace elements of zinc, selenium, ferrum, chromium, copper, molybdenum and manganese. The medical composition is mainly suitable for pregestational women, pregnant women and women who are breastfeeding, is very effective in preventing the birth defects and improving the memory, has both health care and tonic efficacies, and does not generate any side effects even after long-term application.
Description
Technical field:
The present invention relates to the Medicines and Health Product technical field; Pharmaceutical composition in particular for prevention inborn defect and improvement memory.
Background technology:
Inborn defect is meant fetus in parent and in the organ formative process of birth back, by embryo due to the various factors effect and paedomorphosis disorder, comprises that morphosis is unusual, 4 types of physiological metabolism obstacle, congenital feeblemindedness and intrauterine growth retardations etc.; Various countries' inborn defect incidence is up to about 5% of the birth sum, and is great to the population quality influence, causes white elephant for family, society, become the common great public health problem of paying close attention in the present whole world.
The pathogenic factors of inborn defect is very complicated, and inherent cause is arranged, and environmental factor also has other multiple uncertain factor.Environmental factor comprises biological factor, physical factor, chemical factor; The embryo is subjected to the injury of environment adverse factor and other multiple uncertain factor, the inborn defect incidence of disease is increased, and eliminate these adverse factors, and the inborn defect incidence of disease is lowered.
Pharmaceutical composition of the present invention is a policy of following prenatal and postnatal care, by eliminating the inborn defect factor that causes to the embryo, the generation of prevention inborn defect reaches the purpose that lowers the inborn defect incidence of disease, simultaneously user there is the memory impairments of improvement, favourable mothers and sons two generations's health; Said composition comprises the bighead atractylodes rhizome and Fructus Corni, vitamin B compound and trace element zinc, selenium, iron, chromium, copper, molybdenum, manganese.
The bighead atractylodes rhizome is a kind of tonifying Qi class natural traditional Chinese medicine, and strengthening the spleen and replenishing qi is arranged, eliminating dampness Li Shui, hidroschesis show admittedly and in antiabortive effect; Ancient Chinese medicine is classified the bighead atractylodes rhizome as on Chinese medicine product, antiabortive monarch drug in a prescription, the panacea of nourishing the fetus; The modern clinical cirrhotic ascites that are used for more, diarrhoea, Mo Niai syndrome, oedema spontaneous perspiration, fetal irritability etc.; Modern pharmacological research confirms: 1, bighead atractylodes rhizome Wheat Protein, can alleviate peroxidatic reaction of lipid, reduce the content of peroxide, avoid the destruction of harmful substance pair cell 26S Proteasome Structure and Function, and have and improve the active trend of SOD, strengthen the ability of body, thereby reduce the damage of radical pair body radicals scavenging; 2, the bighead atractylodes rhizome has delaying senility function, bighead atractylodes rhizome decoction can improve the erythrocytic superoxide dismutase of aged mouse (SOD) activity, suppresses the brain activity of monoamine oxidase simultaneously, can also suppress erythrocytic autoxidation haemolysis, directly remove free radical, show anti-aging effects; 3, the bighead atractylodes rhizome has the enhancing immunization, and oral lymphocyte transformation rate and the serum IgG content of making of bighead atractylodes rhizome decoction significantly rises, and shows that the bighead atractylodes rhizome has immunostimulation, and can strengthen the vigor of macrophage, strengthens the phagocytic function of reticuloendothelial system; 4, anticancer knurl effect, Baizhu volatile oil has inhibitory action to murine sarcoma S180, and external have direct killing action to the ehrlich ascites tumor cell, and external the Eca109 esophageal cancer cell is presented inhibition, can make cell detachment, karyopycnosis, chromatin concentrates, and cell does not divide or seldom division; 5, the bighead atractylodes rhizome also has the blood lipid-reducing blood sugar-decreasing effect, antibacterial action, and blood coagulation resisting function promotes the brood body weight to increase, physical humidification raises to can be made leukocyte count by the leukopenia that causes after chemotherapy or the radiotherapy tumour; Traditional Chinese medical science custom in prescription the compatibility bighead atractylodes rhizome with the absorption, particularly compatibility gold that promote the medicine effective ingredient, stone class medicine to promote the absorption and the utilization of mineral matter; The bighead atractylodes rhizome is the article that can be used for health food.
Fructus Corni is a kind of can tonifying the liver and kidney as the astringents natural traditional Chinese medicine of health food, restrains astringent or styptic treatment for spontaneous sweating effect; The clinical liver-kidney deficiency that is used for the treatment of, dizzy, impotence, the involuntary emission enuresis, abnormal sweating, illnesss such as metrostaxis; Modern pharmacological research confirms that Fructus Corni has: 1, strengthen immunologic function; 2, activity of fighting against senium; 3, antioxidation; 4, hypoglycemic, effect for reducing blood fat; 5, anti-hemorrhagic shock effect; 6, anti-stress, antifatigue effect; 7, platelet aggregation-against, anti-thrombosis function; 8, strengthen the effect of memory; 9, also have anti-inflammatory in addition, antibiotic, protect the liver, can kill effect such as ascites cells external.
The B family vitamin participates in body internal protein, fat and sugar metabolism, makes the excitement of brain cell and inhibition be in poised state, and it comprises Cobastab
1, Cobastab
2, niacinamide, pantothenic acid, biotin, Cobastab
6, Cobastab
12, folic acid etc., collaborative in vivo performance physiological action.Cobastab
1Have the effect of keeping the nervous system normal function, phenomenon such as it is incomplete to occur glycometabolism during shortage, and heat energy is under-supply, thus cause decrease of memory, influence the normal function of brain, if Cobastab
1Abundance can effectively form the energy of brain cell activity necessity, can improve memory, concentrated force and learning ability, Cobastab in addition
1Suppress CHE in addition, improve the function of cholinergic nerve; Cobastab
2Having another name called riboflavin, is the part of many important coenzyme in the body, and it participates in the metabolism in the body, promotes fetus and growing of baby to play an important role Cobastab to the activity that earns a bare living
2Be to keep skin and the requisite vitamin of eye health, pregnant woman's Cobastab
2Lack or can not cause or inspire pregnant early pregnancy completely and vomit, second trimester angular stomatitis, glossitis, cheilitis and premature's incidence increase; Niacinamide claims niacinamide or nicotinic acid again, and its physiological function is to participate in the body intracellular metabolic, keeps normal neurological function, and bark favus can take place during shortage in synthesizing of assurance sex hormone etc., mainly shows as dermatitis, diarrhoea, dull-witted three big symptoms; Pantothenic acid extensively exists in each organism, participates in metabolic activity widely, and known have 70 plurality of enzymes all to need pantothenic acid to participate in all kinds of biochemical reactions of catalysis body, otherwise just can metabolism disorder; Biotin also is a kind of B family vitamin, coordinates to participate in the metabolism of human body matter and energy with other B family vitamin, and it is synthetic with nucleic acid, and the compositive relation of sex hormone is close, and it also has control white hair, bareheaded effect; Cobastab
6Most important to the maincenter neurodevelopment, if shortage can make the nervous centralis hypoevolutism, intelligence descends, and it has the assistance Cobastab
1Effect, be the vitamin that can improve concentrated force and stimulate desire learn; Cobastab
12Participate in nucleic acid in vivo, choline, amino acid whose synthetic and fat and sugared metabolism, to hemopoietic function of bone marrow, the gastrointestinal epithelial cells function, liver function and nervous system myelin functional integrity have certain effect, it is the necessary vitamin of intelligence of bringing into normal play, not only cause dysnoesia if lack, also alimentary anemia can occur, influence is to blood supply in the brain; Folic acid participates in the synthetic of amino acid and nucleic acid, and and Cobastab
12The common generation that promotes cell is with ripe, and normal cell can not carry out mitosis during shortage, neurologic symptom can occur, as: the loss of memory, depression and dementia etc.; Human body can be at Cobastab in addition
12Under the effect of folic acid as cofactors, by serine of taking in and the synthetic choline of methionine, choline is the chief component of acetylcholine, and acetylcholine is an important neurotransmitter in the human body; Folic acid, Cobastab are arranged again
6And Cobastab
12Can work in coordination with the homotype cysteine of removing in the human body, the homotype cysteine is a kind of neurotoxin, can cause the self-destruction of brain; There are some researches show that homocysteine is a kind of potential teratogenic factor of independently growing, and is related closely with congenital heart disease and NTD; Homocysteine also can cause miscarriage, premature labor in addition, clinical disastrous effect such as pre-eclampsia.
Trace element zinc is merged in the large biological molecule ligand---in protein, nucleic acid, the film (being mainly memebrane protein), generate stable metallic large biological molecule complex compound---metalloprotein, metalloproteinase nucleic acid complex compound etc., at present, known these materials participate in the synthetic and degradation process of carbohydrate, lipid, protein and nucleic acid, and the existence of zinc enzyme is all arranged in six big fermentoids; Zinc also is the essential element that strengthens immune vigor; Zinc can promote that proinsulin is converted into insulin by activating protaminase, and scarce zinc makes insulin be obstructed in the activity of peripheral tissues, and it is unusual to cause glucose tolerance curve; The pregnant woman lacks zinc, can influence growing of fetus to some extent, so that causes all deformities of fetus; Scarce zinc can cause brain development bad, incomplete development of mind.
Trace elements of selenium has obvious reduction serum total cholesterol, triglycerides and MDA, improves HDL, the effect of superabundant fats metabolism in the acceleration bodies; Selenium also has the strong anti-oxidation function, and the protection embryo is not subjected to the injury of superoxides, prevention of cardiac; Anticancer by strengthening immune recognition system to remove cancer cell; Remove and the drainage heavy metal ion, mercury, methyl mercury, cadmium, lead etc. are had detoxication, and heavy metal pollution is mainly to cause the inborn defect factor; Scarce selenium can make human insulin secrete minimizing, and sugar tolerance lowers, and oxidation resistance descends and quickens human senility and intelligence decline.
The major physiological function of trace elements iron is as hemoglobin, myoglobins, and the part of cytochromes etc. participates in transporting and the tissue respiration process of the interior oxygen of body; In the conveying of oxygen and electronics, play central role; Contain iron in the catalatic structure, and hydrogen peroxide relies on catalatic degraded, hydrogen peroxide is a free radical the most dangerous in the human body; Asiderosis is common in infant, pregnant woman and wet nurse, causes hypoferric anemia, and its cardinal symptom is to have a delicate constitution, and memory weakens, and ability to work descends, and iron deficiency also can exert an influence to other system of human body; As the nervous system iron deficiency, can affect the nerves conduction and make children occur that intelligence reduces and behavior disorder.
Chromium is a kind of essential trace element, has only trivalent chromium can be used for the replenishers of chromium, and it can strengthen and promote the physiological action of insulin, and it can harden by prevention of arterial, strengthens immunologic function, promotes to grow; Scarce chromium can cause the stagnation of growing, and quickens old and feeble.
Copper in human body mainly the form with the copper-containing metal enzyme play a role, participate in utilization, hematopoiesis, phosphatide synthetic of iron, a series of metabolic processes such as collagenic connective tissue formation; The shortage of copper can cause collagen cross-linking obstacle in the connective tissue, and heart disease and anaemia, leucocyte reduce, and arterial wall elasticity weakens, albinism etc.
Molybdenum is one of micro elements needed by human, it is the formation element of plurality of enzymes, participate in the utilization of iron, promote erythrocytic growth and maturation, can prevent anaemia, and can help the metabolism of carbohydrate and fat, it participates in removing the murder by poisoning of poisonous aldehydes in the human body, eliminate human free radical, have anticancerly, anti-ageing, strengthen immunity and anticariogenic function; Scarce molybdenum can bring out angiocardiopathy, cancer and carious tooth.
Manganese participates in the formation of some enzymes in human body, it is the metabolism of involved in sugar and lipid not only, and all works in protein, DNA and RVA are synthetic.
Application contains the bighead atractylodes rhizome, Fructus Corni, Cobastab
1, Cobastab
2, Cobastab
6, niacinamide, pantothenic acid, biotin, Cobastab
12, folic acid and trace element zinc, selenium, iron, chromium, copper, molybdenum, manganese has been known as the composition of active principle, but with the bighead atractylodes rhizome and Fructus Corni, Cobastab
1, Cobastab
2, niacinamide, pantothenic acid, biotin, Cobastab
6, Cobastab
12, folic acid and trace element zinc, selenium, iron, chromium, copper, molybdenum, the manganese compatibility pharmaceutical composition that is used for prenatal and postnatal care prevention inborn defect and improves memory report as yet.
Current medicine that is used to improve memory or health food kind have multiple, but aim at pregnant before the medicine or the health food that are used to improve memory of women, pregnant woman, wet nurse's development do not see as yet; Do not see the medicine label that is used to prevent inborn defect as yet, rarely seen report that folic acid prevention NTD is arranged; But its target spot is few, and the link shortcoming needs perfect; And will prevent the effect of inborn defect and improvement memory and be used for same medicine person not see as yet.
Summary of the invention:
In order to overcome existing prevention inborn defect and/or to improve the shortcoming and defect of memory medicine, the purpose of this invention is to provide a kind of composition, said composition promotes the absorption and the utilization of vitamin, mineral matter by the bighead atractylodes rhizome, and with the collaborative Cobastab that increases of Fructus Corni
1, Cobastab
2, Cobastab
6, niacinamide, pantothenic acid, biotin, Cobastab
12, folic acid and trace element zinc, selenium, iron, chromium, copper, molybdenum, manganese improves the effect of memory and prevention inborn defect, simultaneously by trace element zinc, selenium, iron, chromium, copper, molybdenum, manganese and Cobastab
1, Cobastab
2, niacinamide, pantothenic acid, biotin, Cobastab
6, Cobastab
12, folic acid, replenish and strengthen the antiabortive and bighead atractylodes rhizome of bighead atractylodes rhizome nourishing the fetus and Fructus Corni is anti-oxidant, anti-ageing, the enhancing is immune, hypoglycemic, the effect of reducing blood lipid, enhancing memory; Even chronic administration is also without any side effect; Because the result of broad research, the inventor have found the bighead atractylodes rhizome and Fructus Corni, Cobastab
1, Cobastab
2, niacinamide, pantothenic acid, biotin, Cobastab
6, Cobastab
12, folic acid and trace element zinc, selenium, iron, chromium, copper, molybdenum, manganese novel combination, this novel combination is for the prevention inborn defect and improve memory synergy is arranged; And singly use the bighead atractylodes rhizome and Fructus Corni, vitamin B compound and trace element zinc, selenium, iron, chromium, copper, molybdenum, manganese, its effect is all not as good as this composition; And the active ingredient of each component has the addition complementation to the health care help of human body, as the bighead atractylodes rhizome of the used dosage of this composition have nourishing the fetus antiabortive, anti-ageing, strengthen immunity, strengthen the effect of muscle power; Fructus Corni has tonifying the liver and kidney, restrains astringent or styptic treatment for spontaneous sweating effect; Trace element zinc is the necessary material of zinc enzyme in the interior six big fermentoids of human body, also is the essential element that strengthens immune vigor; But the metabolism of superabundant fats has the strong anti-oxidation function, prevention of cardiac function, anti-cancer function etc. in the trace elements of selenium acceleration bodies; Trace elements iron participates in transporting and the tissue respiration process of the interior oxygen of body, is the only element that prevents hypoferric anemia; Trace element chromium has the prevention of arterial sclerosis, strengthens immunity, antidotal function; Trace copper participates in utilization, hematopoiesis, phosphatide synthetic of iron; It is anticancer, anti-ageing that trace element molybdenum has, and strengthens immunity and anticariogenic function; Trace element manganese participates in the synthetic of protein, DNA and RNA; Cobastab
1Can prevent and treat athlete's foot, keep the normal activity of nerve, digestion, muscle, the circulatory system; Cobastab
2Be to keep skin and the requisite vitamin of eye health; Bark favus can take place in nicotinamide deficiency; The pantothenic acid shortage can cause metabolism disorder; Biotin can be prevented and treated white hair, baldness; Cobastab
6Can eliminate intraepithelial neoplasia cells, strengthen immunologic function, the protection blood vessel; Cobastab
12Be used for various megaloblastic anemias and neural disease; Folic acid is protected heart and antitumaous effect in addition; There is not incompatibility in this composition, have no side effect, and cost is low, thereby constitutes the present invention.
The invention provides the pharmaceutical composition that is used to prevent inborn defect and improves memory, it comprises as the bighead atractylodes rhizome of active principle and Fructus Corni, Cobastab
1, Cobastab
2, niacinamide, pantothenic acid, biotin, Cobastab
6, Cobastab
12, folic acid and trace element zinc, selenium, iron, chromium, copper, molybdenum, manganese.
The bighead atractylodes rhizome is the rhizome of the composite family herbaceos perennial bighead atractylodes rhizome (Atractylodes macrocephala koidz).Main product in Zhejiang, ground such as Hubei, Hunan.Gather winter, dries or dry, give birth to or soil is fried, bran is fried and used.The used bighead atractylodes rhizome of the present invention can be with its extract as raw material.
Fructus Corni is that the ripe dry pulp of Cornaceae machaka or arbor Fructus Corni Cornus officinalis Sieb.et Zucc. supplies usefulness, ground such as main product Henan, Shaanxi, Zhejiang, Anhui, Shanxi; The used Fructus Corni of the present invention can be with its extract as raw material.
Be used for Cobastab of the present invention
1(VitaminB
1), Cobastab
2(VitaminB
2), niacinamide (Nicotinamide), pantothenic acid (Pantothenic Acid), biotin (Vitamin H), Cobastab
6(VitaminB
6), Cobastab
12(VitaminB
12), folic acid (Folic Acid), vitamin C (VitaminC), all are water soluble vitamins, do not accumulate in vivo; Zinc (Zn), selenium (Se), iron (Fe), chromium (Cr), copper (Cu), molybdenum (Mo) are micro elements needed by human, and manganese (Mn) is human body possibility essential trace element; Trace element zinc among the present invention can be selected zinc citrate for use, zinc acetate, zinc carbonate, zinc oxide, zinc chloride, zinc lactate, zinc sulfate, zinc gluconate, single zinc methionine etc., trace elements of selenium can be selected selenomethionine for use, methoxybenzyl cyanic acid selenium, the two cyanic acid selenium of phenylene, sodium selenite, selenide of carragheen, selenocysteine, the selenizing methionine, sodium selenate etc., trace elements iron can be selected ferrous gluconate for use, ferrous lactate, ferric citrate, iron chloride, ironic citrate, ferrous carbonate, ferrous citrate, ferrous fumarate, heme iron, ferric pyrophosphate, X-factor, ferrous succinate, ferrous sulfate etc., trace element chromium can be selected chromium trichloride for use, nicotinic acid chromium, chromium picolinate, chromium yeast etc., trace copper can be selected copper carbonate for use, copper citrate, copper gluconate, copper sulphate etc., trace element molybdenum can be selected ammonium molybdate for use, sodium molybdate etc., trace element manganese can be selected manganese sulfate for use, manganese chloride, manganese gluconate, manganese glycerophosphate, manganese citrates etc. all have professional production factory and supplier.
Composition of the present invention mainly is applicable to women in pregnant early stage, pregnant woman and wet nurse; Be subjected to the influence of factors such as geology, food chain, dietetic life custom and Time of Administration length, the effective dose that the crowd that benefits from benefits from this composition each component has certain difference; By the present invention, the effective dose of Rhizoma Atractylodis Macrocephalae extract is counted 300-15000mg/ days with whole crude drug, and the effective dose of cornel extractive is counted 300-10000mg/ days with whole crude drug, Cobastab
1Effective dose be 0.5-20mg/ days, Cobastab
2Effective dose be 0.5-20mg/ days, the effective dose of niacinamide is 5-50mg/ days, the effective dose of pantothenic acid is 2-20mg/ days, the effective dose of biotin is 0.01-0.1mg/ days, Cobastab
6Effective dose be 0.5-10mg/ days, Cobastab
12Effective dose be 0.001-0.025mg/ days, the effective dose of folic acid is 0.1-1mg/ days, the effective dose of trace element zinc is counted 5-20mg/ days with element zinc, and the effective dose of selenium is counted 0.015-0.1mg/ days with elemental selenium, and the effective dose of iron is counted 5-20mg/ days with elemental iron.The effective dose of chromium is counted 0.015-0.15mg/ days with elemental chromium, and the effective dose of copper is counted 0.5-1.5mg/ days with elemental copper, and the effective dose of molybdenum is counted 0.02-0.06mg/ days with molybdenum, and the effective dose of manganese is counted 1-3mg/ days with element manganese.
Composition of the present invention can or directly be taken by following pharmaceutical dosage forms dispenser, for example, oral formulations is (as particle, powder, capsule, ball, sheet, dry syrup, liquid formulation), or food such as food (as biscuit), mix and prepare with other known additives, this class additive is for example: carrier, disintegrant, sustained release agent, excipient, filler, covering, binding agent, lubricant, antioxidant, apply agent, colouring agent, flavouring, sweetener, sucrose succedaneum, nutrition fortifier, flavouring agent, surfactant, plasticizer, the PH conditioning agent, freshener, suspending agent, defoamer, anticorrisive agent, thickener, solubilisation aids etc. are prepared or they are added food as functional component or additive by usual way.
By the present invention, the bighead atractylodes rhizome, Fructus Corni, Cobastab
1, Cobastab
2, niacinamide, pantothenic acid, biotin, Cobastab
6, Cobastab
12, folic acid and trace element zinc, selenium, iron, chromium, copper, molybdenum, manganese each component can distinguish preparation, the preparation of each component can be mixed the back when using and use or do not mix simultaneously and use.
Advantage of the present invention is that this composition is eliminated the multiple factor that causes inborn defect and cause decrease of memory from too many levels, multisystem, many target spots, the effect of collaborative performance effect is arranged between the each component, prevention inborn defect and improvement memory there is significant effect, sufficient raw, cost is low, and each component has no side effect in the composition, no incompatibility, except that prevention inborn defect and improvement memory, human body still there is the health care benefiting action.
Subordinate list 1 is this composition and the bighead atractylodes rhizome and Fructus Corni component and the young rat/mouse labyrinth test effect comparison of vitamin added elements component.
Subordinate list 2 is this composition and the bighead atractylodes rhizome and Fructus Corni component and the comparison of vitamin added elements component Aged Mice maze test effect.
Relatively tabulate below with reference to embodiment and test implementation example effect and to be described in detail the present invention.
Embodiment 1:
Bighead atractylodes rhizome 2000mg,
Fructus Corni 500mg,
Folic acid 0.3mg,
Cobastab
62mg,
Cobastab
120.003mg,
Cobastab
13mg,
Cobastab
23mg,
Niacinamide 10mg,
Zinc lactate (in trace element zinc) 10mg,
Sodium selenate (in trace elements of selenium) 0.02mg,
Ironic citrate (in trace elements iron) 10mg.
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propane diols, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 2:
Bighead atractylodes rhizome 2000mg,
Fructus Corni 500mg,
Folic acid 0.3mg,
Cobastab
62mg,
Cobastab
120.003mg,
Cobastab
13mg,
Cobastab
23mg,
Niacinamide 10mg,
Zinc lactate (in trace element zinc) 8mg,
Sodium selenate (in trace elements of selenium) 0.02mg,
Ironic citrate (in trace elements iron) 10mg,
Chromium yeast (in trace element chromium) 0.02mg,
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propane diols, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 3:
Bighead atractylodes rhizome 2000mg,
Fructus Corni 500mg,
Folic acid 0.3mg,
Cobastab
62mg,
Cobastab
120.003mg,
Cobastab
113mg,
Cobastab
223mg,
Niacinamide 10mg,
Zinc lactate (in trace element zinc) 8mg,
Sodium selenate (in trace elements of selenium) 0.02mg,
Ironic citrate (in trace elements iron) 10mg,
Chromium yeast (in trace element chromium) 0.02mg,
Sodium molybdate (in trace element molybdenum) 0.03mg.
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propane diols, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 4:
Bighead atractylodes rhizome 2000mg,
Fructus Corni 500mg,
Folic acid 0.3mg,
Cobastab
62mg,
Cobastab
120.003mg,
Cobastab
13mg,
Cobastab
23mg,
Niacinamide 10mg,
Zinc lactate (in trace element zinc) 10mg,
Sodium selenate (in trace elements of selenium) 0.02mg,
Ironic citrate (in trace elements iron) 10mg,
Chromium yeast (in trace element chromium) 0.02mg,
Copper citrate (in trace copper) 0.8mg,
Sodium molybdate (in trace element molybdenum) 0.03mg.
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propane diols, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 5:
Bighead atractylodes rhizome 2000mg,
Fructus Corni 500mg,
Folic acid 0.3mg,
Cobastab
62mg,
Cobastab
120.003mg,
Cobastab
13mg,
Cobastab
23mg,
Niacinamide 10mg,
Zinc lactate (in trace element zinc) 10mg,
Sodium selenate (in trace elements of selenium) 0.02mg,
Ironic citrate (in trace elements iron) 10mg,
Chromium yeast (in trace element chromium) 0.02mg,
Copper citrate (in trace copper) 0.8mg,
Sodium molybdate (in trace element molybdenum) 0.03mg,
Manganese citrate (in trace element manganese) 1mg.
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavor enhancement of appropriate amount, again the gained mixture is made 3 bag shot-like particles.Obey every day 3 times, obey a bag at every turn.
Embodiment 6:
Bighead atractylodes rhizome 300mg,
Fructus Corni 300mg,
Folic acid 0.1mg,
Cobastab
60.5mg,
Cobastab
120.001mg,
Cobastab
10.5mg,
Cobastab
20.5mg,
Niacinamide 5mg,
Pantothenic acid 2mg,
Biotin 0.01mg,
Zinc lactate (in trace element zinc) 5mg,
Sodium selenate (in trace elements of selenium) 0.015mg,
Ironic citrate (in trace elements iron) 5mg,
Chromium yeast (in trace element chromium) 0.015mg,
Copper citrate (in trace copper) 0.5mg,
Sodium molybdate (in trace element molybdenum) 0.02mg,
Manganese citrate (in trace element manganese) 1mg.
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavor enhancement of appropriate amount, again the gained mixture is made 3 bag shot-like particles.Obey every day 3 times, obey a bag at every turn.
Embodiment 7:
Bighead atractylodes rhizome 15000mg,
Fructus Corni 10000mg,
Folic acid 1mg,
Cobastab
610mg,
Cobastab
120.025mg,
Cobastab
120mg,
Cobastab
220mg,
Niacinamide 50mg,
Pantothenic acid 20mg,
Biotin 0.1mg,
Zinc lactate (in trace element zinc) 20mg,
Sodium selenate (in trace elements of selenium) 0.1mg,
Ironic citrate (in trace elements iron) 20mg,
Chromium yeast (in trace element chromium) 0.15mg,
Copper citrate (in trace copper) 1.5mg,
Sodium molybdate (in trace element molybdenum) 0.06mg,
Manganese citrate (in trace element manganese) 3mg.
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavor enhancement of appropriate amount, again the gained mixture is made 3 bag shot-like particles.Obey every day 3 times, obey a bag at every turn, serve on 3, withdrew 2, obeyed again 3.
Confirm that through animal experiment this composition belongs to nontoxic level; The crowd takes and does not also see toxicity.
Subordinate list 1: be this composition and the bighead atractylodes rhizome and Fructus Corni component and the young rat/mouse labyrinth test effect comparison of vitamin added elements component:
| Group | Medicine | Consumption | Sample number | The mistake percentage |
| The A group | Control group | 0 | 12 | 21.6％ |
| The B group | The bighead atractylodes rhizome and Fructus Corni group | Bighead atractylodes rhizome 100mg+ Fructus Corni 50mg/ days | 12 | 18.7％ |
| The C group | Vitamin+element set | Zinc 0.1mg+ iron 0.1mg+ selenium 0.001mg+ VB 10.1mg+VB 20.1mg+ niacinamide 0.2mg+VB 60.08mg+VB 120.0001mg+ folic acid 0.008mg/ days | 12 | 15.8％ |
| The D group | The bighead atractylodes rhizome and Fructus Corni+vitamin+element set | Bighead atractylodes rhizome 100mg+ Fructus Corni 50mg+ zinc 0.1mg+ iron 0.1mg+ selenium 0.001mg+VB 10.1mg+ VB 20.1mg+ niacinamide 0.2mg+VB 60.08mg +VB 120.0001mg+ folic acid 0.008mg/ days | 12 | 15％ |
Subordinate list 2: be this composition and the bighead atractylodes rhizome and Fructus Corni component and the comparison of vitamin added elements component Aged Mice maze test effect:
| Group | Medicine | Consumption | Sample number | The mistake percentage |
| The A group | Control group | 0 | 12 | 53.3％ |
| The B group | The bighead atractylodes rhizome and Fructus Corni group | Bighead atractylodes rhizome 100mg+ Fructus Corni 50mg/ days | 12 | 34.6％ |
| The C group | Vitamin+element set | Zinc 0.1mg+ iron 0.1mg+ selenium 0.001mg+ VB 10.1mg+VB 20.1mg+ niacinamide 0.2mg+VB 60.08mg +VB 120.0001mg+ folic acid 0.008mg/ days | 12 | 31.4％ |
| The D group | The bighead atractylodes rhizome and Fructus Corni+vitamin+element set | Bighead atractylodes rhizome 100mg+ Fructus Corni 50mg+ zinc 0.1mg+ iron 0.1mg+ selenium 0.001mg+VB 10.1mg+ VB 20.1mg+ niacinamide 0.2mg+VB 60.08mg +VB 120.0001mg+ folic acid 0.008mg/ days | 12 | 29.9％ |
Annotate: each group is fed to raise by dosage in the table respectively and was tested in 60 days in subordinate list 1, the subordinate list 2; Consumption converts by per kilogram of body weight in the table.
Select 50 of newly-married healthy womens, 25 years old mean age, take this composition continuously from beginning in pregnant preceding 3 months, followed up a case by regular visits to none routine inborn defect in 6 months to the baby due.With associated materials statistics contrasts, inborn defect youngster accounts for the 4-6% of newborn population sum, and there were significant differences.
Can obviously find out from table 1, table 2, this composition is by Chinese medicine component in rat/mouse labyrinth test and the composition and the contrast of vitamin added elements component, mistake percentage statistics, the function of this composition for improved memory is better than Chinese medicine component or vitamin added elements component; With the blank group significant difference is arranged relatively.
Claims (6)
1, a kind of pharmaceutical composition that is used to prevent inborn defect and improves memory is characterized in that it is made by weight ratio by following raw materials according:
Bighead atractylodes rhizome 300-15000mg,
Fructus Corni 300-10000mg,
Folic acid 0.1-1mg,
Cobastab
60.5-10mg,
Cobastab
120.001-0.025mg,
Cobastab
10.5-20mg,
Cobastab
20.5-20mg,
Niacinamide 5-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Zinc 5-20mg,
Selenium 0.015-0.1mg,
Iron 5-20mg,
Chromium 0-0.15mg,
Copper 0-1.5mg,
Molybdenum 0-0.06mg,
Manganese 0-3mg.
2, the pharmaceutical composition that is used to prevent inborn defect and improves memory according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:
Bighead atractylodes rhizome 300-15000mg,
Fructus Corni 300-10000mg,
Folic acid 0.1-1mg,
Cobastab
60.5-10mg,
Cobastab
120.001-0.025mg,
Cobastab
10.5-20mg,
Cobastab
20.5-20mg,
Niacinamide 5-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Zinc 5-20mg,
Selenium 0.015-0.1mg,
Iron 5-20mg,
Chromium 0.015-0.15mg,
Copper 0-1.5mg,
Molybdenum 0-0.06mg,
Manganese 0-3mg.
3, the pharmaceutical composition that is used to prevent inborn defect and improves memory according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:
Bighead atractylodes rhizome 300-15000mg,
Fructus Corni 300-10000mg,
Folic acid 0.1-1mg,
Cobastab
60.5-10mg,
Cobastab
120.001-0.025mg,
Cobastab
10.5-20mg,
Cobastab
20.5-20mg,
Niacinamide 5-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Zinc 5-20mg,
Selenium 0.015-0.1mg,
Iron 5-20mg,
Chromium 0.015-0.15mg,
Copper 0-1.5mg,
Molybdenum 0.02-0.06mg,
Manganese 0-3mg.
4, the pharmaceutical composition that is used to prevent inborn defect and improves memory according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:
Bighead atractylodes rhizome 300-15000mg,
Fructus Corni 300-10000mg,
Folic acid 0.1-1mg,
Cobastab
60.5-10mg,
Cobastab
120.001-0.025mg,
Cobastab
10.5-20mg,
Cobastab
20.5-20mg,
Niacinamide 5-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Zinc 5-20mg,
Selenium 0.015-0.1mg,
Iron 5-20mg,
Chromium 0.015-0.15mg,
Copper 0.5-1.5mg,
Molybdenum 0.02-0.06mg,
Manganese 0-3mg.
5, the pharmaceutical composition that is used to prevent inborn defect and improves memory according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:
Bighead atractylodes rhizome 300-15000mg,
Fructus Corni 300-10000mg,
Folic acid 0.1-1mg,
Cobastab
60.5-10mg,
Cobastab
120.001-0.025mg,
Cobastab
10.520mg,
Cobastab
20.520mg,
Niacinamide 5-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Zinc 5-20mg,
Selenium 0.015-0.1mg,
Iron 5-20mg,
Chromium 0.015-0.15mg,
Copper 0.5-1.5mg,
Molybdenum 0.02-0.06mg,
Manganese 1-3mg.
6, the pharmaceutical composition that is used to prevent inborn defect and improves memory according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:
Bighead atractylodes rhizome 300-15000mg,
Fructus Corni 300-10000mg,
Folic acid 0.1-1mg,
Cobastab
60.5-10mg,
Cobastab
120.001-0.025mg,
Cobastab
10.5-20mg,
Cobastab
20.5-20mg,
Niacinamide 5-50mg,
Pantothenic acid 2-20mg,
Biotin 0.01-0.1mg,
Zinc 5-20mg,
Selenium 0.015-0.1mg,
Iron 5-20mg,
Chromium 0.015-0.15mg,
Copper 0.5-1.5mg,
Molybdenum 0.02-0.06mg,
Manganese 1-3mg.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200810223831XA CN101401644A (en) | 2008-10-08 | 2008-10-08 | Medicament composition for preventing birth-defect and improving memory |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200810223831XA CN101401644A (en) | 2008-10-08 | 2008-10-08 | Medicament composition for preventing birth-defect and improving memory |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101401644A true CN101401644A (en) | 2009-04-08 |
Family
ID=40535918
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA200810223831XA Pending CN101401644A (en) | 2008-10-08 | 2008-10-08 | Medicament composition for preventing birth-defect and improving memory |
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| Country | Link |
|---|---|
| CN (1) | CN101401644A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107106601A (en) * | 2014-10-17 | 2017-08-29 | 菲特弗密私人有限公司 | For treating or preventing the pharmaceutical composition that the vitamin and mineral for the patient for receiving gastric bypass operation lacks |
-
2008
- 2008-10-08 CN CNA200810223831XA patent/CN101401644A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107106601A (en) * | 2014-10-17 | 2017-08-29 | 菲特弗密私人有限公司 | For treating or preventing the pharmaceutical composition that the vitamin and mineral for the patient for receiving gastric bypass operation lacks |
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