CN101297696A - Pharmaceutical combination for preventing birth-defect and improving memory - Google Patents
Pharmaceutical combination for preventing birth-defect and improving memory Download PDFInfo
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- CN101297696A CN101297696A CNA2008101139092A CN200810113909A CN101297696A CN 101297696 A CN101297696 A CN 101297696A CN A2008101139092 A CNA2008101139092 A CN A2008101139092A CN 200810113909 A CN200810113909 A CN 200810113909A CN 101297696 A CN101297696 A CN 101297696A
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Abstract
The invention relates to a drug combination used for preventing birth defects and promoting memory, which comprises Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati, vitamin B compound, vitamin E and microelements zinc, selenium, iron, chrome, copper, molybdenum, iodine and manganese, is mainly applicable to pre-pregnant women, pregnant women and nursing mothers, has good effect on preventing birth defects and promoting memory, meanwhile, has the efficacies of health care and tonifying, and cannot generate any side effect even being used for a long term.
Description
Technical field:
The present invention relates to the Medicines and Health Product technical field.Pharmaceutical composition in particular for prevention inborn defect and improvement memory.
Background technology:
Inborn defect is meant fetus in parent and in the organ formative process of birth back, by embryo due to the various factors effect and paedomorphosis disorder, comprises that morphosis is unusual, 4 types of physiological metabolism obstacle, congenital feeblemindedness and intrauterine growth retardations etc.Various countries' inborn defect incidence is up to about 5% of the birth sum, and is great to the population quality influence, causes white elephant for family, society, become the common great public health problem of paying close attention in the present whole world.
The pathogenic factors of inborn defect is very complicated, and inherent cause is arranged, and environmental factor also has other multiple uncertain factor.Environmental factor comprises biological factor, physical factor, chemical factor; The embryo is subjected to the injury of environment adverse factor and other multiple uncertain factor, the inborn defect incidence of disease is increased, and eliminate these adverse factors, and the inborn defect incidence of disease is lowered.
Pharmaceutical composition of the present invention is a policy of following prenatal and postnatal care, by eliminating the inborn defect factor that causes to the embryo, the generation of prevention inborn defect reaches the purpose that lowers the inborn defect incidence of disease, simultaneously user there is the memory impairments of improvement, favourable mothers and sons two generations's health; Said composition comprises the bighead atractylodes rhizome, sealwort, vitamin B compound, vitamin E and trace element zinc, selenium, iron, chromium, copper, molybdenum, iodine, manganese.
The bighead atractylodes rhizome is a kind of tonifying Qi class natural traditional Chinese medicine, and strengthening the spleen and replenishing qi is arranged, eliminating dampness Li Shui, hidroschesis show admittedly and in antiabortive effect; Ancient Chinese medicine is classified the bighead atractylodes rhizome as on Chinese medicine product, antiabortive monarch drug in a prescription, the panacea of nourishing the fetus; The modern clinical cirrhotic ascites that are used for more, diarrhoea, Mo Niai syndrome, oedema spontaneous perspiration, fetal irritability etc.; Modern pharmacological research confirms: 1, bighead atractylodes rhizome Wheat Protein, can alleviate peroxidatic reaction of lipid, and reduce the content of peroxide, avoid the destruction of harmful substance pair cell 26S Proteasome Structure and Function; And the active trend of the SOD of raising is arranged, strengthen the ability of body, thereby reduce the damage of radical pair body radicals scavenging.2, the bighead atractylodes rhizome has delaying senility function, bighead atractylodes rhizome decoction can improve the erythrocytic superoxide dismutase of aged mouse (SOD) activity, suppresses the brain activity of monoamine oxidase simultaneously, can also suppress erythrocytic autoxidation haemolysis, directly remove free radical, show anti-aging effects.3, the bighead atractylodes rhizome has the enhancing immunization, and oral lymphocyte transformation rate and the serum IgG content of making of bighead atractylodes rhizome decoction significantly rises, and shows that the bighead atractylodes rhizome has immunostimulation, and can strengthen the vigor of macrophage, strengthens the phagocytic function of reticuloendothelial system.4, anticancer knurl effect, Baizhu volatile oil has inhibitory action to murine sarcoma S180, and external have direct killing action to the ehrlich ascites tumor cell, and external the Eca109 esophageal cancer cell is presented inhibition, can make cell detachment, karyopycnosis, chromatin concentrates, and cell does not divide or seldom division.5, the bighead atractylodes rhizome also has the blood lipid-reducing blood sugar-decreasing effect, antibacterial action, and blood coagulation resisting function promotes the brood body weight to increase, physical humidification raises to can be made leukocyte count by the leukopenia that causes after chemotherapy or the radiotherapy tumour.Traditional Chinese medical science custom in prescription the compatibility bighead atractylodes rhizome with the absorption, particularly compatibility gold that promote the medicine effective ingredient, stone class medicine to promote the absorption and the utilization of mineral matter.The bighead atractylodes rhizome is the article that can be used for health food.
Sealwort be a kind of be food be again the deficiency tonifying kind natural traditional Chinese medicine of medicine, have the moistening lung enriching yin, the effect of invigorating the spleen and benefiting qi.Be mainly used in deficiency syndrome of the lung cough caused by dryness, the labor hemoptysis of coughing, essence and blood loses empty, and interior heat is quenched one's thirst, insufficiency of the spleen burnout, the dry food is few, is hard and dry etc.Doctor trained in Western medicine is examined to chronic bronchitis, bronchiectasis, lung cancer, RRTI, pregnant cough, pertussis belong to Lung-Yin deficiency person, and diabetes spp is in lung-stomach yin deficiency card person.Modern pharmacological research confirms that sealwort has: 1, significantly reduce serum cholesterol and triglyceride content, obviously alleviate aorta wall patch and coronary sclerosis.2, obviously reduce the lipofuscin amount of cardiac muscle, improve the liver SOD activity, protection free-radical induced lipid peroxidation and biomembrane damage.3, strengthen the effect of body's immunity.4, obviously resist the effect that PBC reduces.5, effect such as anti-ageing, hypoglycemic, antifatigue, hemostasis, cohesion cancer cell.
The B family vitamin participates in body internal protein, fat and sugar metabolism, makes the excitement of brain cell and inhibition be in poised state, and it comprises Cobastab
1, Cobastab
2, niacinamide, pantothenic acid, biotin, Cobastab
6, Cobastab
12, folic acid etc., collaborative in vivo performance physiological action.Cobastab
1Have the effect of keeping the nervous system normal function, phenomenon such as it is incomplete to occur glycometabolism during shortage, and heat energy is under-supply, thus cause decrease of memory, influence the normal function of brain, if Cobastab
1Abundance can effectively form the energy of brain cell activity necessity, can improve memory, concentrated force and learning ability, Cobastab in addition
1Suppress CHE in addition, improve the function of cholinergic nerve; Cobastab
2Having another name called riboflavin, is the part of many important coenzyme in the body, and it participates in the metabolism in the body, promotes fetus and growing of baby to play an important role Cobastab to the activity that earns a bare living
2Be to keep skin and the requisite vitamin of eye health, pregnant woman's Cobastab
2Lack or can not cause or inspire pregnant early pregnancy completely and vomit, second trimester angular stomatitis, glossitis, cheilitis and premature's incidence increase; Niacinamide claims niacinamide or nicotinic acid again, and its physiological function is to participate in the body intracellular metabolic, keeps normal neurological function, and bark favus can take place during shortage in synthesizing of assurance sex hormone etc., mainly shows as dermatitis, diarrhoea, dull-witted three big symptoms; Pantothenic acid extensively exists in each organism, participates in metabolic activity widely, and known have 70 plurality of enzymes all to need pantothenic acid to participate in all kinds of biochemical reactions of catalysis body, otherwise just can metabolism disorder; Biotin also is a kind of B family vitamin, coordinates to participate in the metabolism of human body matter and energy with other B family vitamin, and it is synthetic with nucleic acid, and the compositive relation of sex hormone is close, and it also has control white hair, bareheaded effect; Cobastab
6Most important to the maincenter neurodevelopment, if shortage can make the nervous centralis hypoevolutism, intelligence descends, and it has the assistance Cobastab
1Effect, be the vitamin that can improve concentrated force and stimulate desire learn; Cobastab
12Participate in nucleic acid in vivo, choline, amino acid whose synthetic and fat and sugared metabolism, to hemopoietic function of bone marrow, the gastrointestinal epithelial cells function, liver function and nervous system myelin functional integrity have certain effect, it is the necessary vitamin of intelligence of bringing into normal play, not only cause dysnoesia if lack, also alimentary anemia can occur, influence is to blood supply in the brain; Folic acid participates in the synthetic of amino acid and nucleic acid, and and Cobastab
12The common generation that promotes cell is with ripe, and normal cell can not carry out mitosis during shortage, neurologic symptom can occur, as: the loss of memory, depression and dementia etc.; Human body can be at Cobastab in addition
12Under the effect of folic acid as cofactors, by serine of taking in and the synthetic choline of methionine, choline is the chief component of acetylcholine, and acetylcholine is an important neurotransmitter in the human body; Folic acid, Cobastab are arranged again
6And Cobastab
12Can work in coordination with the homotype cysteine of removing in the human body, the homotype cysteine is a kind of neurotoxin, can cause the self-destruction of brain; There are some researches show that homocysteine is a kind of potential teratogenic factor of independently growing, and is related closely with congenital heart disease and NTD; Homocysteine also can cause miscarriage, premature labor in addition, clinical disastrous effect such as pre-eclampsia.
Vitamin E is all general designations with the bioactive chromone derivative of alpha-tocopherol, and wherein the activity of alpha-tocopherol is the highest.Have the free radical of elimination, delay senility, prevent the effect of maxicell hemolytic anemia, medically often adopting vitamin E treatment male and female infertility and threatened abortion; TD or pregnant woman's reproductive system is suffered damage, irreversible variation takes place in germinal epithelium, in addition, phenomenons such as maxicell hemolytic anemia and red blood cell life span shortening can take place also.
Trace element zinc is merged in the large biological molecule ligand---in protein, nucleic acid, the film (being mainly memebrane protein), generate stable metallic large biological molecule complex compound---metalloprotein, metalloproteinase nucleic acid complex compound etc., at present, known these materials participate in the synthetic and degradation process of carbohydrate, lipid, protein and nucleic acid; The existence of zinc enzyme is all arranged in six big fermentoids; Zinc also is the essential element that strengthens immune vigor; Zinc can promote that proinsulin is converted into insulin by activating protaminase; Scarce zinc makes insulin be obstructed in the activity of peripheral tissues, and it is unusual to cause glucose tolerance curve; The pregnant woman lacks zinc, can influence growing of fetus to some extent, so that causes all deformities of fetus; Scarce zinc can cause brain development bad, incomplete development of mind.
Trace elements of selenium has obvious reduction serum total cholesterol, triglycerides and MDA, improves HDL, the effect of superabundant fats metabolism in the acceleration bodies; Selenium also has the strong anti-oxidation function, and the protection embryo is not subjected to the injury of superoxides, prevention of cardiac; Anticancer by strengthening immune recognition system to remove cancer cell; Remove and the drainage heavy metal ion, mercury, methyl mercury, cadmium, lead etc. are had detoxication, and heavy metal pollution is mainly to cause the inborn defect factor; Scarce selenium can make human insulin secrete minimizing, and sugar tolerance lowers, and oxidation resistance descends and quickens human senility and intelligence decline.
The major physiological function of trace elements iron is as hemoglobin, myoglobins, and the part of cytochromes etc. participates in transporting and the tissue respiration process of the interior oxygen of body; In the conveying of oxygen and electronics, play central role; Contain iron in the catalatic structure, and hydrogen peroxide relies on catalatic degraded, hydrogen peroxide is a free radical the most dangerous in the human body; Asiderosis is common in infant, pregnant woman and wet nurse, causes hypoferric anemia, and its cardinal symptom is to have a delicate constitution, and memory weakens, and ability to work descends, and iron deficiency also can exert an influence to other system of human body; As the nervous system iron deficiency, can affect the nerves conduction and make children occur that intelligence reduces and behavior disorder.
Chromium is a kind of essential trace element, has only trivalent chromium can be used for the replenishers of chromium, and it can strengthen and promote the physiological action of insulin, and it can harden by prevention of arterial, strengthens immunologic function, promotes to grow; Scarce chromium can cause the stagnation of growing, and quickens old and feeble.
Copper in human body mainly the form with the copper-containing metal enzyme play a role, participate in utilization, hematopoiesis, phosphatide synthetic of iron, a series of metabolic processes such as collagenic connective tissue formation; The shortage of copper can cause collagen cross-linking obstacle in the connective tissue, and heart disease and anaemia, leucocyte reduce, and arterial wall elasticity weakens, albinism etc.
Molybdenum is one of micro elements needed by human, it is the formation element of plurality of enzymes, participate in the utilization of iron, promote erythrocytic growth and maturation, can prevent anaemia, and can help the metabolism of carbohydrate and fat, it participates in removing the murder by poisoning of poisonous aldehydes in the human body, eliminate human free radical, have anticancerly, anti-ageing, strengthen immunity and anticariogenic function; Scarce molybdenum can bring out angiocardiopathy, cancer and carious tooth.
Iodine is the main synthetic thyroid element that participates in human body, and thyroxinic physiological function is to regulate the organism metabolism level, influences the generation of body heat energy, blood sugar and ketoboidies level, muscle and nervous, many-sided functions such as body weight, intelligence and sexual function; Adult's iodine deficiency can cause the thyroid gland enlargement, and fetus and neonate's iodine deficiency can cause deaf and dumb, dull-witted, of short and small stature, spastic paralysi, feeblemindedness, microcephaly in various degree.Serious illness such as low set ears.
Manganese participates in the formation of some enzymes in human body, it is the metabolism of involved in sugar and lipid not only, and all works in protein, DNA and RVA are synthetic.
Application contains the bighead atractylodes rhizome, sealwort, Cobastab
1, Cobastab
2, Cobastab
6, niacinamide, pantothenic acid, biotin, Cobastab
12, folic acid, vitamin E and trace element zinc, selenium, iron, chromium, copper, molybdenum, iodine, manganese has been known as the composition of active principle, but with the bighead atractylodes rhizome and sealwort, Cobastab
1, Cobastab
2, niacinamide, pantothenic acid, biotin, Cobastab
6, Cobastab
12, folic acid, vitamin E and trace element zinc, selenium, iron, chromium, copper, molybdenum, iodine, the manganese compatibility pharmaceutical composition that is used for prenatal and postnatal care prevention inborn defect and improves memory report as yet.
Current medicine that is used to improve memory or health food kind have multiple, but aim at pregnant before the medicine or the health food that are used to improve memory of women, pregnant woman, wet nurse's development do not see as yet; Do not see the medicine label that is used to prevent inborn defect as yet, rarely seen report that folic acid prevention NTD is arranged; But its target spot is few, and the link shortcoming needs perfect.And will prevent the effect of inborn defect and improvement memory and be used for same medicine person not see as yet.
Summary of the invention:
In order to overcome existing prevention inborn defect and/or to improve the shortcoming and defect of memory medicine, the purpose of this invention is to provide a kind of composition, said composition promotes the absorption and the utilization of vitamin, mineral matter by the bighead atractylodes rhizome, and with the collaborative Cobastab that increases of sealwort
1, Cobastab
2, niacinamide, pantothenic acid, biotin, Cobastab
6, Cobastab
12, folic acid, vitamin E and trace element zinc, selenium, iron, chromium, copper, molybdenum, iodine, manganese improves the effect of memory and prevention inborn defect, simultaneously by trace element zinc, selenium, iron, chromium, copper, molybdenum, iodine, manganese and Cobastab
1, Cobastab
2, niacinamide, pantothenic acid, biotin, Cobastab
6, Cobastab
12, folic acid, vitamin E, replenish and strengthen the antiabortive and bighead atractylodes rhizome of bighead atractylodes rhizome nourishing the fetus with sealwort is anti-oxidant, anti-ageing, strengthen immune effect; Even chronic administration is also without any side effect.Because the result of broad research, the inventor have found the bighead atractylodes rhizome and sealwort, Cobastab
1, Cobastab
2, niacinamide, pantothenic acid, biotin, Cobastab
6, Cobastab
12, folic acid, vitamin E and trace element zinc, selenium, iron, chromium, copper, molybdenum, iodine, manganese novel combination, this novel combination is for the prevention inborn defect and improve memory synergy is arranged; And singly use the bighead atractylodes rhizome and sealwort, vitamin B compound, vitamin E and trace element zinc, selenium, iron, chromium, copper, molybdenum, iodine, manganese, its effect is all not as good as this composition; And the active ingredient of each component has the addition complementation to the health care help of human body, as the bighead atractylodes rhizome of the used dosage of this composition have nourishing the fetus antiabortive, anti-ageing, strengthen immunity and strengthen the effect of muscle power; The effect that sealwort has the moistening lung enriching yin, invigorates the spleen and benefits qi; Trace element zinc is the necessary material of zinc enzyme in the interior six big fermentoids of human body, also is the essential element that strengthens immune vigor; But the metabolism of superabundant fats has the strong anti-oxidation function, prevention of cardiac function, anti-cancer function etc. in the trace elements of selenium acceleration bodies; Trace elements iron participates in transporting and the tissue respiration process of the interior oxygen of body, is the only element that prevents hypoferric anemia; Trace element chromium has the prevention of arterial sclerosis, strengthens immunity, antidotal function; Trace copper participates in utilization, hematopoiesis, phosphatide synthetic of iron; It is anticancer, anti-ageing that trace element molybdenum has, and strengthens immunity and anticariogenic function; Trace iodine can be prevented and treated the goitre that iodine deficiency causes, can prevent fetus and neonate's iodine deficiency to cause serious maldevelopment such as cretinism, feeblemindedness; Trace element manganese participates in the synthetic of protein, DNA and RNA; Cobastab
1Can prevent and treat athlete's foot, keep the normal activity of nerve, digestion, muscle, the circulatory system; Cobastab
2Be to keep skin and the requisite vitamin of eye health; Bark favus can take place in nicotinamide deficiency; The pantothenic acid shortage can cause metabolism disorder; Biotin can be prevented and treated white hair, baldness; Cobastab
6Can eliminate intraepithelial neoplasia cells, strengthen immunologic function, the protection blood vessel; Cobastab
12Be used for various megaloblastic anemias and neural disease; Folic acid is protected heart and antitumaous effect in addition; Vitamin E has the free radical of removing, function in delaying senility; There is not incompatibility in this composition, have no side effect, and cost is low, thereby constitutes the present invention.
The invention provides the composition that is used to prevent inborn defect and improves memory, it comprises as the bighead atractylodes rhizome of active principle and sealwort, Cobastab
1, Cobastab
2, niacinamide, pantothenic acid, biotin, Cobastab
6, Cobastab
12, folic acid, vitamin E and trace element zinc, selenium, iron, chromium, copper, molybdenum, iodine, manganese.
The bighead atractylodes rhizome is the rhizome of the composite family herbaceos perennial bighead atractylodes rhizome (Atractylodes macrocephala koidz).Main product in Zhejiang, ground such as Hubei, Hunan.Gather winter, dries or dry, give birth to or soil is fried, bran is fried and used.The used bighead atractylodes rhizome of the present invention can be with its extract as raw material.
Sealwort is the rhizome of Liliaceae herbaceos perennial sealwort Polygonatum sibiricum Red, Yunnan sealwort P.kingianum Coll.et Hemsl. or David's-harp P.cyrtonema Hua.Mostly be wild., Fei Run big with piece, look yellowish-white, the transparent person of section is good.Ripe sealwort is so that look black, piece is big, the big person of oiliness is good.The used sealwort of the present invention can be with its extract as raw material.
Be used for Cobastab of the present invention
1(VitaminB
1), Cobastab
2(VitaminB
2), niacinamide (Nicotinamide), pantothenic acid (Pantothenic Acid), biotin (Vitamin H), Cobastab
6(VitaminB
6), Cobastab
12(VitaminB
12), folic acid (Folic Acid), all are water soluble vitamins, do not accumulate in vivo; Vitamin E (Vitamin E) is a liposoluble vitamin, and is useful and harmless by the used dosage of the present invention; Zinc (Zn), selenium (Se), iron (Fe), chromium (Cr), copper (Cu), molybdenum (Mo), iodine (I) are micro elements needed by human, and manganese (Mn) is human body possibility essential trace element; Trace element zinc among the present invention can be selected zinc citrate for use, zinc gluconate, single zinc methionine etc., trace elements of selenium can be selected selenomethionine for use, methoxybenzyl cyanic acid selenium, the two cyanic acid selenium of phenylene, sodium selenite, sodium selenate etc., trace elements iron can be selected ferrous gluconate for use, ferrous lactate, ferrous sulfate etc., trace element chromium can be selected chromium trichloride for use, nicotinic acid chromium, chromium picolinate, chromium yeast etc., trace copper can be selected copper carbonate for use, copper citrate, copper gluconate, copper sulphate etc., trace element molybdenum can be selected ammonium molybdate for use, sodium molybdate etc., trace iodine can be selected Potassiumiodate etc. for use, trace element manganese can be selected manganese sulfate for use, manganese chloride, manganese citrates etc. all have professional production factory and supplier.
Composition of the present invention mainly is applicable to women in pregnant early stage, pregnant woman and wet nurse; Be subjected to the influence of factors such as geology, food chain, dietetic life custom, the effective dose that the crowd that benefits from benefits from this composition each component has certain difference; By the present invention, the effective dose of Rhizoma Atractylodis Macrocephalae extract is counted 500-15000mg/ days with whole crude drug, and the effective dose of Rhizoma Polygonati extract is counted 300-12000mg/ days with whole crude drug, Cobastab
1Effective dose be 0.5-20mg/ days, Cobastab
2Effective dose be 0.5-20mg/ days, the effective dose of niacinamide is 5-50mg/ days, the effective dose of pantothenic acid is 2-20mg/ days, the effective dose of biotin is 0.01-0.1mg/ days, Cobastab
6Effective dose be 0.5-10mg/ days, Cobastab
12Effective dose be 0.001-0.025mg/ days, the effective dose of folic acid is 0.1-1mg/ days, the effective dose of vitamin E (in the alpha-tocopherol equivalent) is 5-150mg α-TE/ days, the effective dose of trace element zinc is 5-20mg/ days, the effective dose of selenium is 0.015-0.1mg/ days, and the effective dose of iron is 5-20mg/ days.The effective dose of chromium is 0.015-0.15mg/ days, and the effective dose of copper is 0.5-1.5mg/ days, and the effective dose of molybdenum is 0.02-0.06mg/ days, and the effective dose of iodine is 0.05-0.2mg/ days, and the effective dose of manganese is 1-3mg/ days.
Composition of the present invention can or directly be taken by following pharmaceutical dosage forms dispenser, for example, oral formulations is (as particle, powder, capsule, ball, sheet, dry syrup, liquid formulation), or food such as food (as biscuit), mix and prepare with other known additives, this class additive is for example: carrier, disintegrant, sustained release agent, excipient, filler, covering, binding agent, lubricant, antioxidant, apply agent, colouring agent, flavouring, sweetener, sucrose succedaneum, nutrition fortifier, flavouring agent, surfactant, plasticizer, the PH conditioning agent, freshener, suspending agent, defoamer, anticorrisive agent, thickener, solubilisation aids etc. are prepared or they are added food as functional component or additive by usual way.
By the present invention, the bighead atractylodes rhizome, sealwort, Cobastab
1, Cobastab
2, niacinamide, pantothenic acid, biotin, Cobastab
6, Cobastab
12, folic acid, vitamin E and trace element zinc, selenium, iron, chromium, copper, molybdenum, iodine, manganese each component can distinguish preparation, the preparation of each component can be mixed the back when using and use or do not mix simultaneously and use.
Advantage of the present invention is that this composition is eliminated the multiple factor that causes inborn defect and cause decrease of memory from too many levels, multisystem, many target spots, the effect of collaborative performance effect is arranged between the each component, prevention inborn defect and improvement memory there is significant effect, sufficient raw, cost is low, and each component has no side effect in the composition, no incompatibility, except that prevention inborn defect and improvement memory, human body still there is the health care benefiting action.
Subordinate list 1 is this composition and the bighead atractylodes rhizome and sealwort component and the young rat/mouse labyrinth test effect comparison of vitamin added elements component.
Subordinate list 2 is this composition and the bighead atractylodes rhizome and sealwort component and the comparison of vitamin added elements component Aged Mice maze test effect.
Relatively tabulate below with reference to embodiment and test implementation example effect and to be described in detail the present invention.
Embodiment 1:
Bighead atractylodes rhizome 2000mg,
Sealwort 500mg,
Folic acid 0.3mg,
Cobastab
62mg,
Cobastab
120.003mg,
Cobastab
13mg,
Cobastab
23mg,
Niacinamide 10mg,
Zinc lactate (in trace element zinc) 10mg,
Sodium selenate (in trace elements of selenium) 0.02mg,
Ironic citrate (in trace elements iron) 10mg,
Potassiumiodate (in trace iodine) 0.1mg,
Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propane diols, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 2:
Bighead atractylodes rhizome 2000mg,
Sealwort 500mg,
Folic acid 0.3mg,
Cobastab
62mg,
Cobastab
120.003mg,
Cobastab
13mg,
Cobastab
23mg,
Niacinamide 10mg,
Zinc lactate (in trace element zinc) 8mg,
Sodium selenate (in trace elements of selenium) 0.02mg,
Ironic citrate (in trace elements iron) 10mg,
Potassiumiodate (in trace iodine) 0.1mg,
Chromium yeast (in trace element chromium) 0.02mg,
Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propane diols, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 3:
Bighead atractylodes rhizome 2000mg,
Sealwort 500mg,
Folic acid 0.3mg,
Cobastab
62mg,
Cobastab
120.003mg,
Cobastab
13mg,
Cobastab
23mg,
Niacinamide 10mg,
Zinc lactate (in trace element zinc) 8mg,
Sodium selenate (in trace elements of selenium) 0.02mg,
Ironic citrate (in trace elements iron) 10mg,
Potassiumiodate (in trace iodine) 0.1mg,
Chromium yeast (in trace element chromium) 0.02mg,
Sodium molybdate (in trace element molybdenum) 0.03mg,
Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propane diols, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 4:
Bighead atractylodes rhizome 2000mg,
Sealwort 500mg,
Folic acid 0.3mg,
Cobastab
62mg,
Cobastab
120.003mg,
Cobastab
13mg,
Cobastab
23mg,
Niacinamide 10mg,
Zinc lactate (in trace element zinc) 10mg,
Sodium selenate (in trace elements of selenium) 0.02mg,
Ironic citrate (in trace elements iron) 10mg,
Potassiumiodate (in trace iodine) 0.1mg,
Chromium yeast (in trace element chromium) 0.02mg,
Copper citrate (in trace copper) 0.8mg,
Sodium molybdate (in trace element molybdenum) 0.03mg,
Manganese citrate (in trace element manganese) 1mg,
Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propane diols, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 5:
Bighead atractylodes rhizome 2000mg,
Sealwort 500mg,
Folic acid 0.3mg,
Cobastab
62mg,
Cobastab
120.003mg,
Cobastab
13mg,
Cobastab
23mg,
Niacinamide 10mg,
Biotin 0.05mg,
Zinc lactate (in trace element zinc) 10mg,
Sodium selenate (in trace elements of selenium) 0.02mg,
Ironic citrate (in trace elements iron) 10mg,
Potassiumiodate (in trace iodine) 0.1mg
Chromium yeast (in trace element chromium) 0.02mg,
Copper citrate (in trace copper) 0.8mg,
Sodium molybdate (in trace element molybdenum) 0.03mg,
Manganese citrate (in trace element manganese) 1mg,
Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavor enhancement of appropriate amount, again the gained mixture is made 3 bag shot-like particles.Obey every day 3 times, obey a bag at every turn.
Embodiment 6:
Bighead atractylodes rhizome 2000mg,
Sealwort 500mg,
Folic acid 0.3mg,
Cobastab
62mg,
Cobastab
120.003mg,
Cobastab
13mg,
Cobastab
23mg,
Niacinamide 10mg,
Pantothenic acid 10mg,
Biotin 0.05mg,
Zinc lactate (in trace element zinc) 10mg,
Sodium selenate (in trace elements of selenium) 0.02mg,
Ironic citrate (in trace elements iron) 10mg,
Potassiumiodate (in trace iodine) 0.1mg,
Chromium yeast (in trace element chromium) 0.02mg,
Copper citrate (in trace copper) 0.8mg,
Sodium molybdate (in trace element molybdenum) 0.03mg,
Manganese citrate (in trace element manganese) 1mg,
Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavor enhancement of appropriate amount, again the gained mixture is made 3 bag shot-like particles.Obey every day 3 times, obey a bag at every turn.
Confirm that through animal experiment this composition belongs to nontoxic level; The crowd takes and does not also see toxicity.
Subordinate list 1: be this composition and the bighead atractylodes rhizome and sealwort component and the young rat/mouse labyrinth test effect comparison of vitamin added elements component:
| Group | Medicine | Consumption | Sample number | The mistake percentage |
| The A group | Control group | 0 | 12 | 21.6％ |
| The B group | The bighead atractylodes rhizome and sealwort group | Bighead atractylodes rhizome 100mg+ sealwort 50mg/ days | 12 | 18.8％ |
| The C group | Vitamin+element set | Zinc 0.1mg+ iron 0.1mg+ selenium 0.001mg+ iodine 0.003mg+VB 10.1mg+VB 20.1mg+niacinamide 0.2mg+VB 60.08mg +VB 120.0001mg+ folic acid 0.008mg+VE (in the alpha-tocopherol equivalent) 0.5mg α-TE/ days | 12 | 15.6％ |
| The D group | The bighead atractylodes rhizome and sealwort+vitamin+element set | Bighead atractylodes rhizome 100mg+ sealwort 50mg+ zinc 0.1mg+ iron 0.1mg+ selenium 0.001mg+ iodine 0.003mg+VB 10.1mg+VB 20.1mg+ niacinamide 0.2mg+VB 60.08mg+VB 120.0001mg+folic acid 0.008mg+VE (in the alpha-tocopherol equivalent) 0.5mg α-TE/ days | 12 | 14.8％ |
Subordinate list 2: be this composition and the bighead atractylodes rhizome and sealwort component and the comparison of vitamin added elements component Aged Mice maze test effect:
| Group | Medicine | Consumption | Sample number | The mistake percentage |
| The A group | Control group | 0 | 12 | 53.3％ |
| The B group | The bighead atractylodes rhizome and sealwort group | Bighead atractylodes rhizome 100mg+ sealwort 50mg/ days | 12 | 34.9％ |
| The C group | Vitamin+element set | Zinc 0.1mg+ iron 0.1mg+ selenium 0.001mg+ iodine 0.003mg+VB 10.1mg+VB 20.1mg+niacinamide 0.2mg+VB 60.08mg +VB 120.0001mg+ folic acid 0.008mg+VE (in the alpha-tocopherol equivalent) 0.5mg α-TE/ days | 12 | 31.2％ |
| The D group | The bighead atractylodes rhizome and sealwort+vitamin+element set | Bighead atractylodes rhizome 100mg+ sealwort 50mg+ zinc 0.1mg+ iron 0.1mg+ selenium 0.001mg+ iodine 0.003mg+VB 10.1mg+VB 20.1mg+ niacinamide 0.2mg+VB 60.08mg+VB 120.0001mg+folic acid 0.008mg+VE (in the alpha-tocopherol equivalent) 0.5mg α-TE/ days | 12 | 29.8％ |
Annotate: each group is fed to raise by dosage in the table respectively and was tested in 60 days in subordinate list 1, the subordinate list 2; Consumption converts by per kilogram of body weight in the table; Zinc, selenium, iron, iodine are in trace element.
Select 50 of newly-married healthy womens, 25 years old mean age, take this composition continuously from beginning in pregnant preceding 3 months, followed up a case by regular visits to none routine inborn defect in 6 months to the baby due.With associated materials statistics contrasts, inborn defect youngster accounts for the 4-6% of newborn population sum, and there were significant differences.
Can obviously find out from table 1, table 2, this composition is by bighead atractylodes rhizome component in rat/mouse labyrinth test and the composition and the contrast of vitamin added elements component, mistake percentage statistics, the function of this composition for improved memory is better than bighead atractylodes rhizome component or vitamin added elements component; With the blank group significant difference is arranged relatively.
Claims (6)
1, a kind of pharmaceutical composition that is used to prevent inborn defect and improves memory is characterized in that it is made by weight ratio by following raw materials according:
Bighead atractylodes rhizome 500-15000mg,
Sealwort 300-12000mg,
Folic acid 0.1-1mg,
Cobastab
60.5-10mg,
Cobastab
120.001-0.025mg,
Cobastab
10.5-20mg,
Cobastab
20.5-20mg,
Niacinamide 5-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Zinc 5-20mg,
Selenium 0.015-0.1mg,
Iron 5-20mg,
Chromium 0-0.15mg,
Copper 0-1.5mg,
Molybdenum 0-0.06mg,
Iodine 0.05-0.2mg,
Manganese 0-3mg,
Vitamin E 5-150mg a-TE.
2, the pharmaceutical composition that is used to prevent inborn defect and improves memory according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:
Bighead atractylodes rhizome 500-15000mg,
Sealwort 300-12000mg,
Folic acid 0.1-1mg,
Cobastab
60.5-10mg,
Cobastab
120.001-0.025mg,
Cobastab
10.5-20mg,
Cobastab
20.5-20mg,
Niacinamide 5-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Zinc 5-20mg,
Selenium 0.015-0.1mg,
Iron 5-20mg,
Chromium 0.015-0.15mg,
Copper 0-1.5mg,
Molybdenum 0-0.06mg,
Iodine 0.05-0.2mg,
Manganese 0-3mg,
Vitamin E 5-150mg a-TE.
3, the pharmaceutical composition that is used to prevent inborn defect and improves memory according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:
Bighead atractylodes rhizome 500-15000mg,
Sealwort 300-12000mg,
Folic acid 0.1-1mg,
Cobastab
60.5-10mg,
Cobastab
120.001-0.025mg,
Cobastab
10.5-20mg,
Cobastab
20.5-20mg,
Niacinamide 5-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Zinc 5-20mg,
Selenium 0.015-0.1mg,
Iron 5-20mg,
Chromium 0.015-0.15mg,
Copper 0-1.5mg,
Molybdenum 0.02-0.06mg,
Iodine 0.05-0.2mg,
Manganese 0-3mg,
Vitamin E 5-150mg a-TE.
4, the pharmaceutical composition that is used to prevent inborn defect and improves memory according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:
Bighead atractylodes rhizome 500-15000mg,
Sealwort 300-12000mg,
Folic acid 0.1-1mg,
Cobastab
60.5-10mg,
Cobastab
120.001-0.025mg,
Cobastab
10.5-20mg,
Cobastab
20.5-20mg,
Niacinamide 5-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Zinc 5-20mg,
Selenium 0.015-0.1mg,
Iron 5-20mg,
Chromium 0.015-0.15mg,
Copper 0.5-1.5mg,
Molybdenum 0.02-0.06mg,
Iodine 0.05-0.2mg,
Manganese 1-3mg,
Vitamin E 5-150mg a-TE.
5, the pharmaceutical composition that is used to prevent inborn defect and improves memory according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:
Bighead atractylodes rhizome 500-15000mg,
Sealwort 300-12000mg,
Folic acid 0.1-1mg,
Cobastab
60.5-10mg,
Cobastab
120.001-0.025mg,
Cobastab
10.5-20mg,
Cobastab
20.5-20mg,
Niacinamide 5-50mg,
Pantothenic acid 0-20mg,
Biotin 0.01-0.1mg,
Zinc 5-20mg,
Selenium 0.015-0.1mg,
Iron 5-20mg,
Chromium 0.015-0.15mg,
Copper 0.5-1.5mg,
Molybdenum 0.02-0.06mg,
Iodine 0.05-0.2mg,
Manganese 1-3mg,
Vitamin E 5-150mg a-TE.
6, the pharmaceutical composition that is used to prevent inborn defect and improves memory according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:
Bighead atractylodes rhizome 500-15000mg,
Sealwort 300-12000mg,
Folic acid 0.1-1mg,
Cobastab
60.5-10mg,
Cobastab
120.001-0.025mg,
Cobastab
10.5-20mg,
Cobastab
20.5-20mg,
Niacinamide 5-50mg,
Pantothenic acid 2-20mg,
Biotin 0.01-0.1mg,
Zinc 5-20mg,
Selenium 0.015-0.1mg,
Iron 5-20mg,
Chromium 0.015-0.15mg,
Copper 0.5-1.5mg,
Molybdenum 0.02-0.06mg,
Iodine 0.05-0.2mg,
Manganese 1-3mg,
Vitamin E 5-150mg a-TE.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101139092A CN101297696A (en) | 2008-05-29 | 2008-05-29 | Pharmaceutical combination for preventing birth-defect and improving memory |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101139092A CN101297696A (en) | 2008-05-29 | 2008-05-29 | Pharmaceutical combination for preventing birth-defect and improving memory |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101297696A true CN101297696A (en) | 2008-11-05 |
Family
ID=40077754
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2008101139092A Pending CN101297696A (en) | 2008-05-29 | 2008-05-29 | Pharmaceutical combination for preventing birth-defect and improving memory |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101297696A (en) |
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2008
- 2008-05-29 CN CNA2008101139092A patent/CN101297696A/en active Pending
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