CN101391093A - Smoke-stopping liquor and preparation method thereof - Google Patents
Smoke-stopping liquor and preparation method thereof Download PDFInfo
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Abstract
The invention discloses smoking cessation liquid and a preparation method thereof, which is prepared with the following raw materials in weight portions: 25 to 50 portions of rhubarb, 17 to 35 portions of coptis, 5 to 10 portions of phellodendron, 7.5 to 15 portions of sophora flavescens, 5 to 10 portions of notoginseng, 7.5 to 15 portions of cortex moutan, 18 to 35 portions of herba cissampelotis, 2.5 to 5 portions of stogma croci, 7.5 to 15 portions of tangerine peel, 10 to 20 portions of dried ginger, 5 to 10 portions of plum blossom, 7.5 to 15 portions of curcuma longa, 7.5 to 15 portions of patchouli, 2.5 to 5 portions of common fennel and 7.5 to 15 portions of jasmine. The smoking cessation liquid also comprises multiple vitamin and flavor composition. The smoking cessation liquid has the advantages of favorable smoking cessation effect, safety, innocuity, convenient carry about and use, and the like.
Description
Technical field
The present invention relates to a kind of liquid for giving up smoking and preparation method thereof.
Background technology
According to modern scientific research as can be known, at least kind of harmful components surplus containing 2000 in the smog that is produced during cigarette combustion, wherein as benzopyrene, the benzanthracene of polycyclic aromatic hydrocarbon, nitrosamine, polonium 210, cadmium, arsenic, beta-naphthylamine etc. have carcinogenesis, and the short cancer thing in the smoke from cigarette has cyanide, orthoresol and phenol etc.During smoking, the most of pulmonary that sucks of smoke from cigarette, fraction enters digestive tract with saliva.Harmful substance partly rests on pulmonary in the cigarette, and part enters blood circulation, flows to whole body.Under carcinogen and short cancer thing synergism, injuring normal cell can form cancer.Inhale the people of 15 to 20 medicated cigarettes an every day, it easily suffers from the lethal probability of pulmonary carcinoma, oral cancer or laryngeal carcinoma is 14 times of non-smoking people; The lethal chance of its easy trouble esophageal carcinoma is 4 times of non-smoking people; Die from the probability of bladder cancer and want big twice; Die from cardiopathic probability and also want big twice.The cigarette of enfleuraging in addition is to cause chronic bronchitis and emophysematous main cause, and chronic lung disease itself also increases terrible pneumonia and cardiopathic danger, and smoking has also increased hypertensive danger.
Tar, nicotine and carbon monoxide are the harmful components in the Nicotiana tabacum L..Wherein tar contains multiple carcinogen, and it is exactly carcinogenic initiator, carcinogenic promoting agent and collaborative carcinogen that the amount of suction reaches certain level, and it can quicken carcinogenesis, and damage human organ normal cell forms cancer.Carbon monoxide then can lower erythrocyte oxygen is transported to the whole body power of deenergizing.Nicotine then combines with intravital neurotransmitter, causes the lower unit neuronal excitation, inducing neural conduction impulsion.The a large amount of exogenous nicotine of long-term absorption, the people knows from experience and has produced toleration, in case stop smoking, interrupt in exogenous nicotine source, and nicotine blood concentration is lower than 11NG/ML in ES's body, promptly produces anxiety, agitation, constrains, smoking cessation syndromes such as dyspepsia, absent minded, insomnia, it is lasting to cause smoking cessation to be difficult to, therefore, cause the height of smoking relapse rate once more, usually up to 90%～95%.Even instruct smoking cessation by medicine and behavior intervention under doctor's Assistance And Instruction, Jie Yan success rate also has only 30% first.
The existing in the market product that is used to give up smoking is as: smoking give-up chewing gum, smoking cessation paster, smoking cessation cream and tea for smokers to quit smoking etc., but these products still can not reach ideal smoking cessation effect, and some product can only be kept of short duration smoking cessation, is difficult to permanent smoking cessation; Some product then is mainly chemical constituent, and human body is had secondary harm; Also some product carries inconvenience, and the smoker is unwilling to use; Also have some products as falling the nicotine card, the nicotine content that just reduces in the medicated cigarette can not stop smoker's smoking, and it is more also can to allow the smoker smoke, and does not only have the effect of smoking cessation, may also can cause the more serious dependency to Nicotiana tabacum L.; Also have some to attempt to make the synthetic tobacco who contains a small amount of nicotine and reach the purpose that alternative Nicotiana tabacum L. is progressively given up smoking, but effect is still not satisfactory.
Summary of the invention
First purpose of the present invention is to provide a kind of good effect of giving up smoking, safety non-toxic, carries and liquid for giving up smoking easy to use, that be difficult for reverting to take drugs.
Second purpose of the present invention is to provide the preparation method of above-mentioned liquid for giving up smoking.
First purpose of the present invention is achieved through the following technical solutions: a kind of liquid for giving up smoking, it is mainly made by the raw material of following weight portion: 7.5～15 parts of 25～50 parts of Radix Et Rhizoma Rhei, 17～35 parts of Rhizoma Coptidis, 5～10 parts of Cortex Phellodendris, 7.5～15 parts of Radix Sophorae Flavescentiss, 5～10 parts of Radix Notoginseng, 7.5～15 parts of Cortex Moutans, 18～35 parts of Herba Cissampelotis pareiae, 2.5～5 parts of Stigma Crocis, 7.5～15 parts of Pericarpium Citri Reticulataes, 10～20 parts of Rhizoma Zingiberiss, 5～10 parts in Flos Mume, 7.5～15 parts of Radix Curcumaes, 5～10 parts of Herba Pogostemoniss, 2.5～5 parts of Fructus Foeniculi and Flos Jasmini Sambacs.
It is that main component is effectively extracted and human body smoking cessation test that the present invention selects Radix Et Rhizoma Rhei, Rhizoma Coptidis, Cortex Phellodendri, Radix Sophorae Flavescentis, Radix Notoginseng, Cortex Moutan, Herba Cissampelotis pareiae, Stigma Croci, Pericarpium Citri Reticulatae, Rhizoma Zingiberis, Radix Curcumae, Herba Pogostemonis, Fructus Foeniculi, Flos Jasmini Sambac and Flos Mume for use, and filters out best proportioning.Wherein, Radix Et Rhizoma Rhei, Rhizoma Coptidis, Cortex Phellodendri and Radix Sophorae Flavescentis have the effect of heat clearing and damp drying, eliminating fire and detoxication, to the dry pharynx, the bitter taste that cause because of smoking with get angry effective in curely, and can alleviate the toxic action of smoking to liver; Radix Notoginseng, Cortex Moutan, Herba Cissampelotis pareiae and Stigma Croci have the effect of clearing away heat,cooling blood and removing toxin, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain and granulation promoting, can improve smoker's oral ulcer, rhinitis and remove foul smell in the mouth; Pericarpium Citri Reticulatae, Rhizoma Zingiberis and Flos Mume have regulating qi-flowing for strengthening spleen, antiinflammatory and go dry, expectorant etc. that better effects is arranged, and the problems such as excessive phlegm that inappetence that makes the ES just begin to give up smoking to occur and long-term smoking cause improve; Radix Curcumae, Herba Pogostemonis, Fructus Foeniculi and Flos Jasmini Sambac have the effect of eliminating turbid pathogen with aromatics, pure and fresh resolving depression, regulating qi-flowing for strengthening spleen, sensible refreshment, its adding can give full play to stable spirit, it is nervous to releive, relax the insomnia, effect such as improve brain cell vigor, refresh oneself, have one's ideas straightened out.The comprehensive said medicine of using makes each efficacy of drugs produce synergism, thereby improves the pathological changes symptoms such as nasopharynx larynx that the smoker occurs, and stable spirit, releive nervous, relax when the insomnia has just given up smoking the smoker and can spend the transition period restless.
The weight portion of above-mentioned raw materials is: 9～12.5 parts of 35～45 parts of Radix Et Rhizoma Rhei, 25～30 parts of Rhizoma Coptidis, 7～8.5 parts of Cortex Phellodendris, 9～13 parts of Radix Sophorae Flavescentiss, 7～8.5 parts of Radix Notoginseng, 10～12 parts of Cortex Moutans, 25～30 parts of Herba Cissampelotis pareiae, 3.0～4.5 parts of Stigma Crocis, 9～12 parts of Pericarpium Citri Reticulataes, 12～18 parts of Rhizoma Zingiberiss, 6.5～8 parts in Flos Mume, 9～12 parts of Radix Curcumaes, 6～8 parts of Herba Pogostemoniss, 3.0～4.5 parts of Fructus Foeniculi and Flos Jasmini Sambacs.
Be further to strengthen the smoking cessation effect, the present invention can be further improved: the raw material that also comprises following weight portion: 3.5～5.5 parts in 8.5～11 parts of Herba Dendrobiis, 7.5～8.5 parts of Fructus Gardeniaes, 9.0～10.5 parts of Radix Aristolochiaes, 14.5～16 parts of Radix Paeoniae Rubra, 14～15.5 parts of Flos Chrysanthemi Indicis, 9.5～11.5 parts of Lignum Dalbergiae Odoriferaes, 4.5～6 parts of Radix Gentianaes, 9.5～10.5 parts of Flos Campsiss, 9.5～11 parts of Herba Menthaes and Pericarpium Zanthoxyli.
Be preferably 4.0～5.0 parts in 9～10 parts of Herba Dendrobiis, 7.8～8.2 parts of Fructus Gardeniaes, 9.5～10.2 parts of Radix Aristolochiaes, 15～15.5 parts of Radix Paeoniae Rubra, 14.5～15 parts of Flos Chrysanthemi Indicis, 9.8～11.2 parts of Lignum Dalbergiae Odoriferaes, 4.8～5.5 parts of Radix Gentianae, 9.8～10.2 parts of Flos Campsiss, 10～10.5 parts of Herba Menthaes and Pericarpium Zanthoxyli.
Herba Dendrobii, nourishing YIN and clearing away heat, reinforcing stomach reg fluid; Fructus Gardeniae, clearing away heat,cooling blood and removing toxin, pathogenic fire purging relieving restlessness; Radix Aristolochiae, removing toxic substances and promoting subsidence of swelling; Radix Paeoniae Rubra, clearing away heat and cooling blood, eliminating stasis to stop pain; Flos Chrysanthemi Indici, heat-clearing and toxic substances removing; Lignum Dalbergiae Odoriferae, promoting flow of QI and blood; Radix Gentianae, heat clearing and damp drying, eliminating pathogen in the liver gallbladder fire; Flos Campsis, the promoting the circulation of blood blood stasis dispelling; Herba Menthae, expelling wind and cold, ward off dirty, the detoxifcation; Pericarpium Zanthoxyli, warming spleen and stomach for dispelling cold, dehumidifying, pain relieving.The use of said medicine strengthens effects for removing toxic heat of the present invention, alleviates further that toxic component promotes the Nicotiana tabacum L. toxic component to decompose also and excretes the damage of internal organs in the smog of Nicotiana tabacum L..And improve the physiological function of pulmonary, recover pulmonary's vigor.
Also comprise compound vitamin in the described liquid for giving up smoking, the concentration of described compound vitamin is 0.15～0.2mg/ml.
Described compound vitamin is a kind of or two or more the mixing arbitrarily in vitamin A, vitamin B, vitamin C and the beta-carotene.The vitamin A that wherein contains has anti-respiratory system infection effect, helps function of immune system normal.Vitamin B complex is regulated metabolism, keeps the health of skin and muscle, promotes immune system and neural function, promotes cell growth and division.β one carotene; effectively remove free radical, build up resistance; repair lung tissue; strengthen the defence capability of organ internal organs mucosa system; improve the resistance infection of respiratory system; liver cell is formed layer protecting film, stop chemical substance invasion infringement liver in the tobacco poisoning, alleviate the damage of tobacco poisoning liver.Vitamin C has the effect of antioxidation antidotal; the protection immune system is built up resistance, and prevents allergy; eliminate foreign body toxicity; reduce side effect such as cigarette, wine, medicine, in the part smoking population because of hyperactivity of fire caused by deficiency of YIN, endocrine disturbance, cause being irritable and getting angry easily, vitimin supplement C; it is good neural tranquillizer; after the circulation suction was heard and entered nasal cavity, its improved effect spirit and balance emotion were improved sleep.
Described liquid for giving up smoking comprises that also the percentage by weight that accounts for total solution weight is 1～3% edible essence.
Second purpose of the present invention is achieved through the following technical solutions: a kind of preparation method of above-mentioned liquid for giving up smoking, and it may further comprise the steps:
(1) takes by weighing each raw material by weight ratio, pulverize, sieve;
(2) raw material after pulverizing adds 4～12 times of water boiling and extraction twice, extracts 2～5h at every turn, merges extracted twice liquid, filters, concentrate concentrated solution;
(3) step (2) gained concentrated solution is ground into fine powder after 75 ℃～100 ℃ oven dry, than being to be dissolved in water at 1～3: 500, filters to get filtrate by weight;
(4) add ethanol in the filtrate and carry out precipitate with ethanol, the limit edged stirs, and standing over night is got supernatant then, and precipitate is repeated precipitate with ethanol 2 times, merges supernatant;
(5) supernatant leaves standstill, and filters, and gets settled solution, packing.
Each raw material powder is broken into 60～100 purpose granules in the described step (1); Concentrated solution is ground into 90～100 purpose fine powders in the described step (3) after oven dry.
Raw material after pulverizing in the described step (2) decocts with water when extracting, and adds 8～12 times of amounts of water for the first time; Add for the second time 4～7 times of amounts of water.
The ethanol that is adopted in the described step (4) is 70%～95% ethanol; Alcoholic acid use amount is: be added into that concentration of alcohol is 60%～70% in the filtrate.
When adding compound vitamin and edible essence in liquid for giving up smoking, described step (5) is: supernatant leaves standstill, and filters, and gets settled solution, adds compound vitamin and edible essence mix homogeneously, packing.The addition of described compound vitamin is every ml soln 0.15～0.2mg; The percentage by weight that edible essence accounts for total solution weight is 1～3% edible essence.
Described compound vitamin is a kind of or two or more the mixing arbitrarily in vitamin A, vitamin B, vitamin C and the beta-carotene.
Using method of the present invention: open bottle cap when thinking smoking, inhale news with deep breathing method, the snuffing mouth is exhaled, and hears 5～10 minutes at every turn, once a day or repeatedly, uses continuously three days; For the people who smokes like a chimney, the length of smoking is long, can use a week or the longer time.
Smoking cessation principle of the present invention: liquid for giving up smoking of the present invention contains the effective ingredient of multiple heat-clearing and toxic substances removing and regulating qi-flowing for strengthening spleen, and contain compound vitamin, its effective ingredient is after nose sucks, on be advanced into brain, it is turbid to give full play to its change, pure and fresh resolving depression, the effect of sensible refreshment, can be stable spiritual, it is nervous to releive, relax the insomnia, improve effects such as brain cell vigor, when just having been given up smoking, the smoker can spend the transition period restless, under be advanced into the bottom of heart and each organ, bring into play its heat clearing and damp drying, the effect of eliminating fire and detoxication, the harmful substance of smoker's body inner accumulated is progressively decomposed and excreted, alleviated the infringement of harmful substance each internal organs; Its reinforcing stomach reg fluid, regulating qi-flowing for strengthening spleen composition can effectively be alleviated the inappetence situation that the smoker causes because of smoking cessation; Effects such as compound vitamin can play and regulate human physiological functions, enhance metabolism, enhancing immunity.
The present invention has following advantage:
(1) good effect of giving up smoking
Thousands of routine clinical trial through Guangdong People's Hospital's 3000 routine clinical trials and cardiovascular diseases hospital of the Chinese Academy of Medical Sciences 500 examples and other two tame hospitals shows that using liquid for giving up smoking of the present invention smoker's after 3 days quit smoking rate is 98%.Simultaneously, find seldom not revert to take drugs the person by paying a return visit.
Below bright for instance effect of the present invention:
Xu Honglin, the man has 55 year length of smoking, use this product after, given up craving for tobacco, do not have recurrence so far through paying a return visit.
Li Xingbo, the man has 48 year length of smoking, use this product after, given up craving for tobacco, do not have recurrence so far through paying a return visit.
Wang Shaorong, the woman has 45 year length of smoking, use this product after, given up craving for tobacco, do not have recurrence so far through paying a return visit.
Wang Hui, the man has 37 year length of smoking, use this product after, given up craving for tobacco, do not have recurrence so far through paying a return visit.
Hu Mingwen, the man has 20 year length of smoking, use this product after, given up craving for tobacco, do not have recurrence so far through paying a return visit.
In duckweed, the woman has 20 year length of smoking, use this product after, given up craving for tobacco, do not have recurrence so far through paying a return visit.
Liu Zonghui, the man has 15 year length of smoking, use this product after, given up craving for tobacco, do not have recurrence so far through paying a return visit.
Huang Jianhua, the man has 10 year length of smoking, use this product after, given up craving for tobacco, do not have recurrence so far through paying a return visit.
Jia Qin, the woman has 10 year length of smoking, use this product after, given up craving for tobacco, do not have recurrence so far through paying a return visit.
Tian Wei, the woman has 3 year length of smoking, use this product after, given up craving for tobacco, do not have recurrence so far through paying a return visit.
(2) safety non-toxic
The using method of liquid for giving up smoking according to the present invention is got 3 bottles of liquid for giving up smoking, and wherein internal diameter of the bottleneck is about 1.3cm, 25 ℃, the 30min that volatilizees naturally, 3 bottles average weight loss is 0.0156g as a result, the average weight of supposing the adult is 60kg, and calculating the once complete suction volume of people in view of the above is 0.260 μ g/kg.With liquid for giving up smoking of the present invention by the adult once fully 500 times of suction volume give the disposable subcutaneous injection of mice, observed seven days, the Total Test mice is good for and deposits; By the adult once fully 20 times of suction volume give the injection of mice disposable vein, observed seven days, no abnormality seen as a result, the Total Test mice is good for and deposits, and illustrates that liquid for giving up smoking of the present invention is very safe.And through testing the LD that finds mouse subcutaneous injection
50Dosage be 345 μ g/kg, quite the people is once fully 1327 times of suction volume; The LD of mouse mainline
50Dosage be 10.48 μ g/kg, quite the people is once fully 40 times of suction volume.
Simultaneously, the LD of product of the present invention
50Disposable celiac injection be 0.15ml/kg, get product LD of the present invention
501/2,1/4,1,/10 three dosage group, disposable celiac is expelled to (about 20g) on the Male Kunming strain mice, other establishes normal control and cyclophosphamide positive controls, put to death in 24～30 hours after the experimental animal administration, get the film-making of femur bone marrow cell, methanol is fixed, the Giemsa 10min that dyes, the micronucleus number in the counting polychromatophilia erythrocyte.The result shows that the micronucleus number that brings out in the mouse bone marrow cells polychromatophilia erythrocyte do not find to raise, and micronuclear rates and dosage do not have dependency, and the micronucleus test result is negative, illustrates that this product has no side effect.
(3) carry with easy to use: liquid for giving up smoking of the present invention is a Chinese medicine extraction liquid, and safety non-toxic, easy to carry is when thinking smoking, open bottle cap, the snuffing mouth is exhaled, once a day or repeatedly, the general use can effectively be given up smoking in 3 days, and severe patient uses also can give up craving for tobacco in 3～7 days.
(4) the present invention contains the medicine of multiple heat-clearing and toxic substances removing, also can be used for the treatment of rhinitis.
The specific embodiment
Below in conjunction with embodiment and Comparative Examples the present invention is set forth, yet protection scope of the present invention is not only to be confined to following examples.The person of an ordinary skill in the technical field all can realize purpose of the present invention according to content disclosed by the invention.
Embodiment one:
Raw material:
Radix Et Rhizoma Rhei 250g Rhizoma Coptidis 170g Cortex Phellodendri 50g Radix Sophorae Flavescentis 75g Radix Notoginseng 50g
Cortex Moutan 75g Herba Cissampelotis pareiae 180g Stigma Croci 25g Pericarpium Citri Reticulatae 75g Rhizoma Zingiberis 100g
Flos Mume 50g Radix Curcumae 75g Herba Pogostemonis 50g Fructus Foeniculi 25g Flos Jasmini Sambac 75g
Preparation process:
(1) gets above-mentioned materials of weight proportions and pulverize 100 order granules, sieve;
(2) raw material after gained is pulverized filters with the water boiling and extraction 3h of 8 times of amounts, gets extracting solution A, and is standby; Filtering residue is used the water extraction 3h of 4 times of amounts once more, filters, and gets extracting solution B; Merge extracted twice liquid, filter, be condensed into concentrated solution;
(3) concentrated solution is ground into 100 order fine powders 90 ℃ of oven dry, is dissolved in water by 1: 500 w/v, filters, and gets filtrate;
(4) adding concentration in the gained filtrate is 70% ethanol, and it is about 65% of filtrate that the limit edged is stirred to amount of alcohol, and standing over night is got supernatant 1;
(5) adding concentration in precipitate is 65% ethanol, fully stirs standing over night, get supernatant 2, in lower floor's precipitate, add concentration once more and be 65% ethanol extraction supernatant 3, three supernatant are merged, elimination impurity leaves standstill, and gets the upper strata settled solution and gets brown liquid; Get liquid for giving up smoking, packing.
Embodiment two:
Raw material:
Radix Et Rhizoma Rhei 380g Rhizoma Coptidis 250g Cortex Phellodendri 75g Radix Sophorae Flavescentis 110g Radix Notoginseng 75g
Cortex Moutan 110g Herba Cissampelotis pareiae 270g Stigma Croci 35g Pericarpium Citri Reticulatae 115g Rhizoma Zingiberis 150g
Flos Mume 75g Radix Curcumae 115g Herba Pogostemonis 75g Fructus Foeniculi 37g Flos Jasmini Sambac 115g
Preparation process:
(1) gets above-mentioned materials of weight proportions and pulverize 60 order granules, sieve;
(2) raw material after gained is pulverized filters with the water boiling and extraction 2h of 10 times of amounts, gets extracting solution A, and is standby; Filtering residue is used the water extraction 2h of 5 times of amounts once more, filters, and gets extracting solution B; Merge extracted twice liquid, filter, be condensed into concentrated solution;
(3) concentrated solution is ground into 90 order fine powders 80 ℃ of oven dry, is dissolved in water by 1.5: 500 w/vs, filters, and gets filtrate;
(4) adding concentration in the gained filtrate is 80% ethanol, and it is about 60% of filtrate that the limit edged is stirred to amount of alcohol, and standing over night is got supernatant 1;
(5) adding concentration in precipitate is 60% ethanol, fully stirs standing over night, get supernatant 2, in lower floor's precipitate, add concentration once more and be 60% ethanol extraction supernatant 3, three supernatant are merged, elimination impurity leaves standstill, and gets the upper strata settled solution and gets brown liquid; Add compound vitamin and edible essence mix homogeneously then, get liquid for giving up smoking, packing.The concentration of compound vitamin is 0.17mg/ml in the solution, and the weight percent content of edible essence is 1.5%.
Embodiment three:
Raw material:
Radix Et Rhizoma Rhei 500g Rhizoma Coptidis 350g Cortex Phellodendri 100g Radix Sophorae Flavescentis 150g Radix Notoginseng 100g
Cortex Moutan 150g Herba Cissampelotis pareiae 350g Stigma Croci 50g Pericarpium Citri Reticulatae 150g Rhizoma Zingiberis 200g
Flos Mume 100g Radix Curcumae 150g Herba Pogostemonis 100g Fructus Foeniculi 50g Flos Jasmini Sambac 150g
Preparation process:
(1) gets above-mentioned materials of weight proportions and pulverize 90 order granules, sieve;
(2) raw material after gained is pulverized filters with the water boiling and extraction 4h of 12 times of amounts, gets extracting solution A, and is standby; Filtering residue is used the water extraction 4h of 6 times of amounts once more, filters, and gets extracting solution B; Merge extracted twice liquid, filter, be condensed into concentrated solution;
(3) concentrated solution is ground into 100 order fine powders 100 ℃ of oven dry, is dissolved in water by 2: 500 w/vs, filters, and gets filtrate;
(4) adding concentration in the gained filtrate is 95% ethanol, and it is about 70% of filtrate that the limit edged is stirred to amount of alcohol, and standing over night is got supernatant 1;
(5) adding concentration in precipitate is 70% ethanol, fully stirs standing over night, get supernatant 2, in lower floor's precipitate, add concentration once more and be 70% ethanol extraction supernatant 3, three supernatant are merged, elimination impurity leaves standstill, and gets the upper strata settled solution and gets brown liquid; Add compound vitamin and edible essence mix homogeneously then, get liquid for giving up smoking.The concentration of compound vitamin is 0.2mg/ml in the solution, and the weight percent content of edible essence is 3%.
Embodiment four:
Raw material:
Radix Et Rhizoma Rhei 300g Rhizoma Coptidis 250g Cortex Phellodendri 60g Radix Sophorae Flavescentis 90g Radix Notoginseng 60g
Cortex Moutan 90g Herba Cissampelotis pareiae 200g Stigma Croci 30g Pericarpium Citri Reticulatae 90g Rhizoma Zingiberis 120g
Flos Mume 55g Radix Curcumae 80g Herba Pogostemonis 60g Fructus Foeniculi 30g Flos Jasmini Sambac 100g
Herba Dendrobii 90g Fructus Gardeniae 78g Radix Aristolochiae 95g Radix Paeoniae Rubra 150g Flos Chrysanthemi Indici 145g
Lignum Dalbergiae Odoriferae 100g Radix Gentianae 50g Flos Campsis 95g Herba Menthae 95g Pericarpium Zanthoxyli 40g
Preparation process:
(1) gets above-mentioned materials of weight proportions and pulverize 80 order granules, sieve;
(2) raw material after gained is pulverized filters with the water boiling and extraction 5h of 10 times of amounts, gets extracting solution A, and is standby; Filtering residue is used the water extraction 5h of 5 times of amounts once more, filters, and gets extracting solution B; Merge extracted twice liquid, filter, be condensed into concentrated solution;
(3) concentrated solution is ground into 90 order fine powders 85 ℃ of oven dry, is dissolved in water by 3: 500 w/vs, filters, and gets filtrate;
(4) adding concentration in the gained filtrate is 85% ethanol, and it is about 65% of filtrate that the limit edged is stirred to amount of alcohol, and standing over night is got supernatant 1;
(5) adding concentration in precipitate is 65% ethanol, fully stirs, and standing over night is got supernatant 2, adds concentration once more and be 65% ethanol in lower floor's precipitate, fully stirs, and standing over night is extracted supernatant 3.Three supernatant are merged, and elimination impurity leaves standstill, and gets the upper strata settled solution and gets brown liquid; Add compound vitamin and edible essence mix homogeneously then, get liquid for giving up smoking, packing.The concentration of compound vitamin is 0.19mg/ml in the solution, and the weight percent content of edible essence is 2.5%.
Embodiment five:
Raw material:
Radix Et Rhizoma Rhei 400g Rhizoma Coptidis 300g Cortex Phellodendri 80g Radix Sophorae Flavescentis 125g Radix Notoginseng 80g
Cortex Moutan 120g Herba Cissampelotis pareiae 250g Stigma Croci 35g Pericarpium Citri Reticulatae 120g Rhizoma Zingiberis 150g
Flos Mume 75g Radix Curcumae 120g Herba Pogostemonis 75g Fructus Foeniculi 37g Flos Jasmini Sambac 125g
Herba Dendrobii 100g Fructus Gardeniae 80g Radix Aristolochiae 98g Radix Paeoniae Rubra 152g Flos Chrysanthemi Indici 147g
Lignum Dalbergiae Odoriferae 105g Radix Gentianae 52g Flos Campsis 100g Herba Menthae 102g Pericarpium Zanthoxyli 45g
Preparation process:
(1) gets above-mentioned materials of weight proportions and pulverize 70 order granules, sieve;
(2) raw material after gained is pulverized filters with the water boiling and extraction 2h of 10 times of amounts, gets extracting solution A, and is standby; Filtering residue is used the water extraction 2h of 5 times of amounts once more, filters, and gets extracting solution B; Merge extracted twice liquid, filter, be condensed into concentrated solution;
(3) concentrated solution is ground into 100 order fine powders 90 ℃ of oven dry, is dissolved in water by 1: 500 w/v, filters, and gets filtrate;
(4) adding concentration in the gained filtrate is 70% ethanol, and it is about 65% of filtrate that the limit edged is stirred to amount of alcohol, and standing over night is got supernatant 1;
(5) adding concentration in precipitate is 65% ethanol, fully stirs standing over night, get supernatant 2, in lower floor's precipitate, add concentration once more and be 65% ethanol extraction supernatant 3, three supernatant are merged, elimination impurity leaves standstill, and gets the upper strata settled solution and gets brown liquid; Add compound vitamin and edible essence mix homogeneously then, get liquid for giving up smoking, packing.The concentration of compound vitamin is 0.15mg/ml in the solution, and the weight percent content of edible essence is 1%.
Embodiment six:
Raw material:
Radix Et Rhizoma Rhei 500g Rhizoma Coptidis 350g Cortex Phellodendri 100g Radix Sophorae Flavescentis 150g Radix Notoginseng 100g
Cortex Moutan 150g Herba Cissampelotis pareiae 350g Stigma Croci 50g Pericarpium Citri Reticulatae 150g Rhizoma Zingiberis 200g
Flos Mume 100g Radix Curcumae 150g Herba Pogostemonis 100g Fructus Foeniculi 50g Flos Jasmini Sambac 150g
Herba Dendrobii 110g Fructus Gardeniae 85g Radix Aristolochiae 105g Radix Paeoniae Rubra 160g Flos Chrysanthemi Indici 155g
Lignum Dalbergiae Odoriferae 115g Radix Gentianae 60g Flos Campsis 100g Herba Menthae 102g Pericarpium Zanthoxyli 45g
Preparation process:
(1) gets above-mentioned materials of weight proportions and pulverize 80 order granules, sieve;
(2) crude drug after gained is pulverized filters with the water boiling and extraction 3h of 8 times of amounts, gets extracting solution A, and is standby; Filtering residue is used the water extraction 2h of 5 times of amounts once more, filters, and gets extracting solution B; Merge extracted twice liquid, filter, be condensed into concentrated solution;
(3) concentrated solution is ground into 90 order fine powders 85 ℃ of oven dry, is dissolved in water by 3: 500 w/vs, filters, and gets filtrate;
(4) adding concentration in the gained filtrate is 70% ethanol, and it is about 60% of filtrate that the limit edged is stirred to amount of alcohol, and standing over night is got supernatant 1;
(5) adding concentration in precipitate is 60% ethanol, fully stirs, and standing over night is got supernatant 2, adds concentration once more and be 60% ethanol in lower floor's precipitate, fully stirs, and standing over night is extracted supernatant 3.Three supernatant are merged, and elimination impurity leaves standstill, and gets the upper strata settled solution and gets brown liquid; Add compound vitamin and edible essence mix homogeneously then, get liquid for giving up smoking, packing.The concentration of compound vitamin is 0.16mg/ml in the solution, and the weight percent content of edible essence is 2%.
Claims (10)
1. liquid for giving up smoking, it is characterized in that it is mainly made by the raw material of following weight portion: 7.5～15 parts of 25～50 parts of Radix Et Rhizoma Rhei, 17～35 parts of Rhizoma Coptidis, 5～10 parts of Cortex Phellodendris, 7.5～15 parts of Radix Sophorae Flavescentiss, 5～10 parts of Radix Notoginseng, 7.5～15 parts of Cortex Moutans, 18～35 parts of Herba Cissampelotis pareiae, 2.5～5 parts of Stigma Crocis, 7.5～15 parts of Pericarpium Citri Reticulataes, 10～20 parts of Rhizoma Zingiberiss, 5～10 parts in Flos Mume, 7.5～15 parts of Radix Curcumaes, 5～10 parts of Herba Pogostemoniss, 2.5～5 parts of Fructus Foeniculi and Flos Jasmini Sambacs.
2. according to the described liquid for giving up smoking of claim 1, it is characterized in that the weight portion of described raw material is: 9～12.5 parts of 35～45 parts of Radix Et Rhizoma Rhei, 25～30 parts of Rhizoma Coptidis, 7～8.5 parts of Cortex Phellodendris, 9～13 parts of Radix Sophorae Flavescentiss, 7～8.5 parts of Radix Notoginseng, 10～12 parts of Cortex Moutans, 25～30 parts of Herba Cissampelotis pareiae, 3.0～4.5 parts of Stigma Crocis, 9～12 parts of Pericarpium Citri Reticulataes, 12～18 parts of Rhizoma Zingiberiss, 6.5～8 parts in Flos Mume, 9～12 parts of Radix Curcumaes, 6～8 parts of Herba Pogostemoniss, 3.0～4.5 parts of Fructus Foeniculi and Flos Jasmini Sambacs.
3. according to claim 1 or 2 described liquid for giving up smoking, it is characterized in that it also comprises following weight portion raw material: 3.5～5.5 parts in 8.5～11 parts of Herba Dendrobiis, 7.5～8.5 parts of Fructus Gardeniaes, 9.0～10.5 parts of Radix Aristolochiaes, 14.5～16 parts of Radix Paeoniae Rubra, 14～15.5 parts of Flos Chrysanthemi Indicis, 9.5～11.5 parts of Lignum Dalbergiae Odoriferaes, 4.5～6 parts of Radix Gentianae, 9.5～10.5 parts of Flos Campsiss, 9.5～11 parts of Herba Menthaes and Pericarpium Zanthoxyli.
4. according to the described liquid for giving up smoking of claim 3, it is characterized in that the weight portion of described raw material is: 4.0～5.0 parts in 9～10 parts of Herba Dendrobiis, 7.8～8.2 parts of Fructus Gardeniaes, 9.5～10.2 parts of Radix Aristolochiaes, 15～15.5 parts of Radix Paeoniae Rubra, 14.5～15 parts of Flos Chrysanthemi Indicis, 9.8～11.2 parts of Lignum Dalbergiae Odoriferaes, 4.8～5.5 parts of Radix Gentianae, 9.8～10.2 parts of Flos Campsiss, 10～10.5 parts of Herba Menthaes and Pericarpium Zanthoxyli.
5. according to the described liquid for giving up smoking of claim 3, it is characterized in that it also comprises compound vitamin and edible essence; Wherein said compound vitamin concentration is 0.15～0.2mg/ml; The percentage by weight that described edible essence accounts for total solution weight is 1～3%.
6. the preparation method of claim 1 or 2 or 3 described liquid for giving up smoking is characterized in that it may further comprise the steps:
(1) takes by weighing each raw material by weight ratio, pulverize, sieve;
(2) raw material after pulverizing adds 4～12 times of water boiling and extraction twice, extracts 2～5h at every turn, merges extracted twice liquid, filters, concentrate concentrated solution;
(3) step (2) gained concentrated solution is ground into fine powder after 75 ℃～100 ℃ oven dry, than being to be dissolved in water at 1～3: 500, filters to get filtrate by weight;
(4) add ethanol in the filtrate and carry out precipitate with ethanol, the limit edged stirs, and standing over night is got supernatant then, and precipitate is repeated precipitate with ethanol 2 times, merges supernatant;
(5) supernatant leaves standstill, and filters, and gets settled solution, packing.
7. the preparation method of the described liquid for giving up smoking of claim 5 is characterized in that, it may further comprise the steps:
(1) takes by weighing each raw material by weight ratio, pulverize, sieve;
(2) raw material after pulverizing adds 4～12 times of water boiling and extraction twice, extracts 2～5h at every turn, merges extracted twice liquid, filters, concentrate concentrated solution;
(3) step (2) gained concentrated solution is ground into fine powder after 75 ℃～100 ℃ oven dry, than being to be dissolved in water at 1～3: 500, filters to get filtrate by weight;
(4) add ethanol in the filtrate and carry out precipitate with ethanol, the limit edged stirs, and standing over night is got supernatant then, and precipitate is repeated precipitate with ethanol 2 times, merges supernatant;
(5) supernatant leaves standstill, and filters, and gets settled solution, adds compound vitamin and edible essence mix homogeneously, packing.
8. according to the preparation method of claim 6 or 7 described liquid for giving up smoking, it is characterized in that each raw material powder is broken into 60～100 purpose granules in the described step (1); Concentrated solution is ground into 90～100 purpose fine powders in the described step (3) after oven dry.
9. according to the preparation method of claim 6 or 7 described liquid for giving up smoking, it is characterized in that the raw material after pulverizing in the described step (2) decocts with water when extracting, and adds 8～12 times of amounts of water for the first time; Add for the second time 4～7 times of amounts of water.
10. according to the preparation method of claim 6 or 7 described liquid for giving up smoking, it is characterized in that the ethanol that is adopted in the described step (4) is 70%～95% ethanol; Alcoholic acid use amount is: be added into that concentration of alcohol is 60%～70% in the filtrate.
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