CN101385788A - Chinese herbal medicine preparation for treating ascitic type liver cancer - Google Patents
Chinese herbal medicine preparation for treating ascitic type liver cancer Download PDFInfo
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- CN101385788A CN101385788A CNA200810130374XA CN200810130374A CN101385788A CN 101385788 A CN101385788 A CN 101385788A CN A200810130374X A CNA200810130374X A CN A200810130374XA CN 200810130374 A CN200810130374 A CN 200810130374A CN 101385788 A CN101385788 A CN 101385788A
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Abstract
The invention relates to a Chinese herbal preparation for treating ascitic-type liver cancer. The novelty of the Chinese herbal preparation is that hereditary secret formula originally consists of six Chinese herbs by percentages for treating liver cancer, especially the ascetic-type liver cancer: 19-21% of Japanese ginseng, 19-21% of senna, 19-21% of inula herb, 14-16% of thinleaf buckthorn root, 14-16% of manchurian dutchmanspipe, and 9-11% of euphoribia neriifolia (stamen). The practicality of the Chinese herbal preparation is that the Japanese ginseng contains chikusetsu saponin, and aglucone is oleanolic acid; the senna contains aloe emodin and tannin; the inula herb contains britanin and inulicin; the thinleaf buckthorn root contains 1-O-methyl-inositol; the manchurian dutchmanspipe contains aristolochic acid, the oleanolic acid and hederagenin; and the euphoribia neriifolia contains gallic acid. Tests prove that the pharmacology of a drug extracted from the secret formula inhibits the growth of rat ascetic-type liver cancer, mice S-37 and S-AK which have intraperitoneal injection for a plurality of times. The rats are injected with 5mg/kg of the Chinese herbal preparation into abdominal cavities per day or orally administered 10mg/kg of the Chinese herbal preparation for 30 days, but no death case happens. Conclusion is that the secrete formula of the Chinese herbal preparation contains a key anti-cancer component aristolochic acid, and the Chinese herbal preparation is administered after being made into a concentrate according to the percentage of the secrete formula or a decoction form according to the weight gram. Creativity is that 10 cases with the ascetic-type liver cancer are treated clinically, wherein, oral decoction cures 2 cases, oral concentrate cures 6 cases, effective case is one and ineffective case is one, so that the total effective rate is up to 85% and the curative ratio is up to 65%.
Description
Technical field: the present invention relates to a kind of Chinese herbal medicine secret recipe of hepatocarcinoma, particularly a kind of Chinese herbal and crude drugs preparations for the treatment of ascitic type liver cancer.
Background technology: the Chinese invention patent original applying number is 031244963, the applying date is on May 29th, 2003, and open day is on February 18th, 2004, and the application people generally belongs to mid and late liver cancer for the patent documentation record ascitic type liver cancer of Liao Yin Dynasty, its treatment effective percentage is more than 80%, and cure rate is more than 60%.
Summary of the invention: the object of the present invention is to provide a kind of Chinese herbal and crude drugs preparations for the treatment of ascitic type liver cancer, its treatment is than the patent of invention effective percentage and the cure rate height of original application.
The technical scheme that technical solution problem of the present invention is adopted: novelty according to secret prescription handed down in the family from generation to generation and I practise medicine clinical practice experience invention treatment hepatocarcinoma particularly the Chinese herbal medicine secret recipe of middle and advanced stage ascitic type liver cancer apply for that at first following percentage by weight encloses: Rhizoma Panacis Japonici 19-21%, Herba Cassiae Mimosoidis 19-21%, Herba Inulae 19-21%, Mencius's root 14-16%, Caulis Aristolochiae Manshuriensis 14-16%, Caulis Euphorbiae Neriifoliae (pistil) 9-11%.The composition that records secret prescription handed down in the family from generation to generation Six-element Chinese herbal medicine of practicality basis " Chinese medicine voluminous dictionary ": Rhizoma Panacis Japonici contains the ring glycoside, and glycoside unit is an oleanolic acid.Herba Cassiae Mimosoidis contains aloe-emodin, tannin.Herba Inulae contains britanin and inulin.Mencius's root contains the 1-0-methyl-inositol.Caulis Aristolochiae Manshuriensis contains Aristolochic Acid, oleanolic acid, hederagenin.The Caulis Euphorbiae Neriifoliae flower contains not stone acid.The pharmacological action of the medicine that decocting extracts is adopted in experiment from Six-element Chinese herbal medicine secret recipe be repeatedly to do the growth that lumbar injection can suppress rat ascites type hepatocarcinoma, to the growth of mice S-37, S-AK also some inhibition.Give the medicine totally 30 days of 5 milligrams/kilogram of rat lumbar injections every day or oral 10 milligrams of/kilogram extractions, it is dead not see that toxic reaction takes place, and is the effectively nontoxic tumor preparation that presses down.Sum up Six-element Chinese herbal medicine secret recipe of the present invention from the analysis of the experimental effect of above-mentioned record and contain anticancer main component Aristolochic Acid, clinical confirmation is effective to ascitic type liver cancer, percentage ratio according to secret recipe is made concentrate, take according to the explanation of bottle card, perhaps the weight in grams numeral system according to secret recipe becomes soup (frying in shallow oil) agent to take.
Beneficial effect of the present invention: to be that this preparation is clinical treat 10 examples to ascitic type liver cancer to creativeness, oral decoct is cured 2 examples, oral concentrate is cured 6 examples, effective 1 example, invalid 1 example, suiting the medicine to the illness, observing takes medicine promptly shows normal urination, ascites is dwindled thereupon or is disappeared, and by the dirty thing discharge of foul smelling blood stasis down, more the recurrence death is not seen in the back drug withdrawal more than 10 years from stool, total effective rate is more than 85%, and cure rate is more than 65%.
Description of drawings:
Fig. 1 is that novelty secret prescription handed down in the family from generation to generation figure Fig. 2 is that experimental effect figure Fig. 3 of practicality secret recipe is the clinical efficacy figure embodiment of creative secret recipe: Six-element Chinese herbal medicine secret prescription handed down in the family from generation to generation drug weight percentage ratio preparation in description of drawings 1: Rhizoma Panacis Japonici 20%, Herba Cassiae Mimosoidis 20%, Herba Inulae 20%, Mencius's root 15%, Caulis Aristolochiae Manshuriensis 15%, Caulis Euphorbiae Neriifoliae (pistil) 10%.Batching: water, flour.
(1) above-mentioned Six-element Chinese herbal medicine secret prescription handed down in the family from generation to generation is pulverized added water according to percentage by weight and drop into for 1 jin and fry in shallow oil into decoction in steaming jar and concentrate, add batching flour and even again, put into medicament-making device and make granular concentrate oven dry, the bottling sealing is taken according to the explanation of bottle card.
(2) above-mentioned Six-element Chinese herbal medicine secret prescription handed down in the family from generation to generation is pulverized added water with the weight in grams number and go into to fry in shallow oil in the jar bottling of patent medicine decoction for 1 jin and take according to the explanation of bottle card.
Claims (3)
1, a kind of Chinese herbal and crude drugs preparations for the treatment of ascitic type liver cancer, novelty secret prescription handed down in the family from generation to generation of the present invention apply at first by Rhizoma Panacis Japonici, Herba Cassiae Mimosoidis, Herba Inulae, Mencius's root, Caulis Aristolochiae Manshuriensis, Caulis Euphorbiae Neriifoliae (pistil) Six-element hepatocarcinoma particularly the Chinese herbal medicine of ascitic type liver cancer form.Practicality is the composition that records secret prescription handed down in the family from generation to generation Six-element Chinese herbal medicine according to " Chinese medicine voluminous dictionary ": Rhizoma Panacis Japonici contains the ring glycoside, and glycoside unit is an oleanolic acid.Herba Cassiae Mimosoidis contains aloe-emodin, tannin.Herba Inulae contains britanin and inulin.Mencius's root contains the 1-0-methyl-inositol.Caulis Aristolochiae Manshuriensis contains Aristolochic Acid, oleanolic acid, hederagenin.The Caulis Euphorbiae Neriifoliae flower contains not stone acid.The pharmacological action of the medicine that decocting extracts is adopted in experiment from Six-element Chinese herbal medicine secret recipe be repeatedly to do the growth that lumbar injection can suppress rat ascites type hepatocarcinoma, to the growth of mice S-37, S-AK also some inhibition.Give the medicine totally 30 days of 5 milligrams/kilogram of rat lumbar injections every day or oral 10 milligrams of/kilogram extractions, it is dead not see that toxic reaction takes place, and is the effectively nontoxic tumor preparation that presses down.Sum up Six-element Chinese herbal medicine secret recipe of the present invention from the analysis of the experimental effect of above-mentioned record and contain anticancer main component Aristolochic Acid.To be that this preparation is clinical treat 10 examples to ascitic type liver cancer to creativeness, and oral decoct is cured 2 examples, and oral concentrate is cured 6 examples, effective 1 example, and invalid 1 example, total effective rate is more than 85%, and cure rate is more than 65%.
Table 1 is that novelty secret prescription handed down in the family from generation to generation table 2 is that the experimental effect table 3 of practicality secret recipe is the clinical efficacy of creative secret recipe
The percentage by weight that it is characterized in that secret prescription handed down in the family from generation to generation encloses: Rhizoma Panacis Japonici 19-21%, Herba Cassiae Mimosoidis 19-21%, Herba Inulae 19-21%, Mencius's root 14-16%, Caulis Aristolochiae Manshuriensis 14-16%, Caulis Euphorbiae Neriifoliae (pistil) 9-11%.
2, a kind of Chinese herbal and crude drugs preparations for the treatment of ascitic type liver cancer according to claim 1 is characterized in that the percentage by weight of secret prescription handed down in the family from generation to generation: Rhizoma Panacis Japonici 20%, Herba Cassiae Mimosoidis 20%, Herba Inulae 20%, Mencius's root 15%, Caulis Aristolochiae Manshuriensis 15%, Caulis Euphorbiae Neriifoliae (pistil) 10%.
3, a kind of Chinese herbal and crude drugs preparations for the treatment of ascitic type liver cancer according to claim 1 is characterized in that the medicine manufacturing comprises granular concentrate and decoction.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200810130374XA CN101385788A (en) | 2008-07-11 | 2008-07-11 | Chinese herbal medicine preparation for treating ascitic type liver cancer |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200810130374XA CN101385788A (en) | 2008-07-11 | 2008-07-11 | Chinese herbal medicine preparation for treating ascitic type liver cancer |
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| CN101385788A true CN101385788A (en) | 2009-03-18 |
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| CNA200810130374XA Pending CN101385788A (en) | 2008-07-11 | 2008-07-11 | Chinese herbal medicine preparation for treating ascitic type liver cancer |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103610682A (en) * | 2013-12-04 | 2014-03-05 | 中国科学院华南植物园 | Preparation method of 3(alpha)-hydroxyl-30-olive-12,20(29)-diene-28-acid and application in preparing anti-tumor drug |
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2008
- 2008-07-11 CN CNA200810130374XA patent/CN101385788A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103610682A (en) * | 2013-12-04 | 2014-03-05 | 中国科学院华南植物园 | Preparation method of 3(alpha)-hydroxyl-30-olive-12,20(29)-diene-28-acid and application in preparing anti-tumor drug |
| CN103610682B (en) * | 2013-12-04 | 2015-08-19 | 中国科学院华南植物园 | The preparation method of 3 Alpha-hydroxy-30-olive-12,20 (29)-diene-28-acid and preparing the application in antitumor drug |
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| C57 | Notification of unclear or unknown address | ||
| DD01 | Delivery of document by public notice |
Addressee: Liao Yin Document name: Notification of acceptance Addressee: Liao Yin Document name: Approval notice for cost mitigation |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20090318 |