CN101380634A - Cleaning technique of rubber piston of disposable sterile syringe - Google Patents
Cleaning technique of rubber piston of disposable sterile syringe Download PDFInfo
- Publication number
- CN101380634A CN101380634A CNA2008102249600A CN200810224960A CN101380634A CN 101380634 A CN101380634 A CN 101380634A CN A2008102249600 A CNA2008102249600 A CN A2008102249600A CN 200810224960 A CN200810224960 A CN 200810224960A CN 101380634 A CN101380634 A CN 101380634A
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- rubber piston
- rinsing
- rubber
- hydrogen peroxide
- sterile syringe
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- Apparatus For Disinfection Or Sterilisation (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention provides a washing technology for a rubber piston of a disposable sterilized syringe which is produced by taking a natural rubber as material. The washing technology is characterized in that peroxide is used as a washing agent; the rubber piston to be washed is dipped by a peroxide liquid; then tap water and de-ionized water are used for rinsing; finally, double-distilled water is used for rinsing and airing. The physicochemical property indexes and the biochemical property indexes of the rubber piston washed by the invention completely meet the regulation of GB/T 15810 Disposable Sterilized Syringe; the easy oxide content is 0.5 which is lower than the lowest limit of 1.5 regulated in the GB/T 15810 and can not affect the existing production technique for the rubber piston of the disposable sterilized syringe.
Description
[invention field]
The present invention relates to adopt the cleaning technique of the disposable sterilized injector of natural rubber production with rubber piston.
[background technology]
Disposable syringe is the most frequently used medicine equipment of medium being introduced human body of medical department.Known disposable sterilized syringe is made up of syringe jacket, core bar and the rubber piston that is contained in the core bar termination, as 00129166.1,02122937.6,01116424.7,02266406.6,92266406.8,99201489.1,99227320.x 03264656.9,200420064447.7 all has description in various degree.Rubber piston is as the disposable syringe auxiliary products, belong to national medicine equipment three series products, relevant standard GB/T 15810 " disposable sterilized injector " has strict demand to physical property, chemical property and the biological property etc. of rubber piston, especially in the chemical property index, the readily oxidizable substance value is a most important index, and whether its whether qualified biological property that directly has influence on rubber piston meets standard-required.
The cleaning method of traditional natural rubber piston is, adopt hydrochloric acid as cleaning agent, concrete technology is as follows: with rubber piston with abluent slightly wash, running water rinsing, hydrochloric acid solution immersions, running water rinsing, deionized water and two distilled water fine purifiations that steam, carry out the surface siliconization processing at last.This method mainly is to utilize the osmosis of hydrochloric acid, and readily oxidizable substance is extracted from rubber piston, removes by rinsing again.The weak point of this method is: the readily oxidizable substance value fluctuation of the rubber piston after (1) is cleaned is bigger, the quality instability; (2) remaining in acid solution in the rubber piston slit, to be difficult for thorough rinsing clean, causes the pH value in the chemical property index of rubber piston easily to exceed standard; (3) hydrochloric acid solution corrodes the healthy of production equipment, contaminated environment, harm workman easily.
Therefore, be necessary to provide a kind of more effective, safer, equipment, environment and operator are influenced the cleaning technique of less disposable sterilized injector with rubber piston.
[summary of the invention]
The object of the present invention is to provide a kind of cleaning technique of rubber piston for disposable sterile syringe, reduce the readily oxidizable substance content of this rubber piston effectively, guarantee the safety of product, and influence less equipment, environment and operator.
Specifically, the present invention adopts hydrogen peroxide as cleaning agent, to remove with the natural rubber by redox reaction be raw material, adopt the readily oxidizable substance of the rubber piston for disposable sterile syringe (hereinafter to be referred as rubber piston) that general formulation and production technology and equipment makes, thus the safety in utilization of raising disposable sterilized injector.
Specific embodiments of the present invention is as follows:
Adopt hydrogen peroxide as cleaning agent, rubber piston to be cleaned with hydrogenperoxide steam generator immersions, running water rinsing, again with deionized water and twoly steam the distilled water rinsings, after drying, is carried out the surface siliconization processing.
Cleaning agent of the present invention, optional hydrogenperoxide steam generator, preferred content of hydrogen peroxide are the aqueous hydrogen peroxide solution of 5%～10% commercial grade.
Therefore, the cleaning technique of rubber piston for disposable sterile syringe of the present invention, preferably adopt following embodiment:
To be raw material with the natural rubber, adopting the rubber piston of the different size of general formulation and conventional production process production be that 5%～10% aqueous hydrogen peroxide solution soaked 10～14 hours at normal temperatures with the content of hydrogen peroxide that is equivalent to 2 times of rubber piston weight to be cleaned; Then, adopt running water and deionized water difference rinsing 2～4 times, each 20～40 minutes, again with two steaming distilled water rinsings 2～4 times, each 20～40 minutes, after drying, carry out surface siliconization and handle at last.
After adopting the technology of the present invention that rubber piston is cleaned, the readily oxidizable substance content of rubber piston is about 0.5, be lower than the minimum of GB/T 15810 " disposable sterilized injector " regulation and limit the quantity of 1.5, all the other physics and chemistry and biochemical property index meet the regulation of GB/T 15810 " disposable sterilized injector " fully.
The hydrogen peroxide that the present invention adopts has: (1) nontoxic, odorless; (2) do not contain heavy metal; (3) environmentally safe, to the production equipment non-corrosiveness, have no irritating odor, less to the healthy harm of workman.
The present invention can not influence the production technology of existing disposable syringe rubber piston.
[embodiment]
The present invention will be described hereinafter to adopt non-limiting embodiment.
Embodiment 1
Get 5 kilograms with the natural rubber be raw material routinely the production technology specification of producing be the rubber piston of 2.5ml, with 10 kilograms of content of hydrogen peroxide is that 5% aqueous hydrogen peroxide solution soaked 12 hours, adopt 10 kilograms of running water and deionized water difference rinsing 2 times then, each 30 minutes, adopt 10 kilograms of two distilled water rinsing 3 times, each 30 minutes of steaming at last.After drying, carry out surface siliconization and handle.Randomly draw three batches of rubber pistons after the cleaning, press GB/T14233.2 " medical infusion, blood transfusion, the instrument used for injection method of inspection " and measure physics, chemistry and biochemical property, wherein readily oxidizable substance content is respectively 0.46,0.42 with 0.32, remaining pH value, content of beary metal and thermal source, haemolysis, the check of whole body acute toxicity all meet the requirement of GB/T 15810 " disposable sterilized injector ".
Embodiment 2
Get 5 kilograms with the natural rubber be raw material routinely the production technology specification of producing be the rubber piston of 5ml, with 10 kilograms of content of hydrogen peroxide is that 7% aqueous hydrogen peroxide solution soaked 13 hours, adopt 10 kilograms of running water and deionized water difference rinsing 2 times then, each 30 minutes, adopt 10 kilograms of two distilled water rinsing 3 times, each 30 minutes of steaming at last.After drying, carry out surface siliconization and handle.Randomly draw three batches of rubber pistons after the cleaning, press GB/T14233.2 " medical infusion, blood transfusion, the instrument used for injection method of inspection " and measure physics, chemistry and biochemical property, wherein readily oxidizable substance content is respectively 0.53,0.52 with 0.56, remaining pH value, content of beary metal and thermal source, haemolysis, the check of whole body acute toxicity all meet the requirement of GB/T 15810 " disposable sterilized injector ".
Embodiment 3
Get 5 kilograms with the natural rubber be raw material routinely the production technology specification of producing be the rubber piston of 10ml, with 10 kilograms of content of hydrogen peroxide is that 10% aqueous hydrogen peroxide solution soaked 12 hours, adopt 10 kilograms of running water and deionized water difference rinsing 2 times then, each 30 minutes, adopt 10 kilograms of two distilled water rinsing 3 times, each 30 minutes of steaming at last.After drying, carry out surface siliconization and handle.Randomly draw three batches of rubber pistons after the cleaning, press GB/T14233.2 " medical infusion, blood transfusion, the instrument used for injection method of inspection " and measure physics, chemistry and biochemical property, wherein readily oxidizable substance content is respectively 0.58,0.53 with 0.59, remaining pH value, content of beary metal and thermal source, haemolysis, the check of whole body acute toxicity all meet the requirement of GB/T15810 " disposable sterilized injector ".
Embodiment 4
Get 5 kilograms with the natural rubber be raw material routinely the production technology specification of producing be the rubber piston of 20ml, with 10 kilograms of content of hydrogen peroxide is that 10% aqueous hydrogen peroxide solution soaked 12 hours, adopt 10 kilograms of running water and deionized water difference rinsing 2 times then, each 30 minutes, adopt 10 kilograms of two distilled water rinsing 3 times, each 30 minutes of steaming at last.After drying, carry out surface siliconization and handle.Randomly draw three batches of rubber pistons after the cleaning and measure physics, chemistry and biochemical property by GB/T14233.2 " medical infusion, blood transfusion, the instrument used for injection method of inspection ", wherein readily oxidizable substance content is respectively 0.58,0.59 and 0.72, and remaining pH value, content of beary metal and thermal source, haemolysis, the check of whole body acute toxicity all meet the requirement of GB/T15810 " disposable sterilized injector ".
Claims (3)
1. the cleaning technique of a rubber piston for disposable sterile syringe is characterized in that adopting hydrogen peroxide as cleaning agent, and rubber piston is soaked with hydrogenperoxide steam generator, use running water and rinsed with deionized water again, with the rinsing of two steaming distilled water, dry at last, carry out surface siliconization and handle.
2. the cleaning technique of rubber piston for disposable sterile syringe according to claim 1, it is characterized in that rubber piston to be cleaned was soaked 10～14 hours at normal temperatures with hydrogenperoxide steam generator, adopt running water and deionized water difference rinsing 2～4 times then, each 20～40 minutes, adopt two distilled water rinsing 2～4 times, each 20～40 minutes of steaming at last.
3. according to the described rubber piston for disposable sterile syringe cleaning technique of claim 1～2, it is characterized in that described hydrogenperoxide steam generator is that content of hydrogen peroxide is 5%～10% aqueous hydrogen peroxide solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008102249600A CN101380634B (en) | 2008-10-28 | 2008-10-28 | Cleaning technique of rubber piston of disposable sterile syringe |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008102249600A CN101380634B (en) | 2008-10-28 | 2008-10-28 | Cleaning technique of rubber piston of disposable sterile syringe |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101380634A true CN101380634A (en) | 2009-03-11 |
| CN101380634B CN101380634B (en) | 2011-01-26 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008102249600A Expired - Fee Related CN101380634B (en) | 2008-10-28 | 2008-10-28 | Cleaning technique of rubber piston of disposable sterile syringe |
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| Country | Link |
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| CN (1) | CN101380634B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104629084A (en) * | 2015-02-09 | 2015-05-20 | 浙江理工大学 | Cleaning method of waste polytetrafluoroethylene filter bag |
-
2008
- 2008-10-28 CN CN2008102249600A patent/CN101380634B/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104629084A (en) * | 2015-02-09 | 2015-05-20 | 浙江理工大学 | Cleaning method of waste polytetrafluoroethylene filter bag |
| CN104629084B (en) * | 2015-02-09 | 2018-02-06 | 浙江理工大学 | A kind of cleaning method of waste and old polytetrafluoroethylene (PTFE) filter bag |
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| Publication number | Publication date |
|---|---|
| CN101380634B (en) | 2011-01-26 |
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Granted publication date: 20110126 Termination date: 20131028 |