CN101375810A - Device for causing injury of laboratory animal - Google Patents
Device for causing injury of laboratory animal Download PDFInfo
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- CN101375810A CN101375810A CNA2008102223441A CN200810222344A CN101375810A CN 101375810 A CN101375810 A CN 101375810A CN A2008102223441 A CNA2008102223441 A CN A2008102223441A CN 200810222344 A CN200810222344 A CN 200810222344A CN 101375810 A CN101375810 A CN 101375810A
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Abstract
The invention provides a device for causing damage to an experimental animal, which comprises a platform and an altitude controller arranged on the platform, and further comprises a striking component, a horizontal bracket and a vertical bracket; the striking component comprises a striking bar, a striking head, a guiding pipe, an electromagnet, a power and a switch; the guiding pipe, which is an open-ended through-tube, is fixed on the horizontal bracket; a cover of the striking bar is arranged in clearance fit with the guiding pipe; one end of the striking bar is connected with the striking head, and the other end of the striking bar is made of ferromagnetic materials and arranged in the magnetic field produced by the electromagnet; the electromagnet and the power are electrically connected with the switch; the altitude controller and the vertical bracket are vertically connected with the horizontal bracket; and the electromagnet is fixed on the vertical bracket. The device causes fixed-point and fixed-amount damage to animal tissue such as spinal cord, reduces artificial errors through mechanized operation, and enhances the repeatability of an experiment.
Description
Technical field
The present invention relates to a kind of device that causes injury of laboratory animal.
Background technology
Spinal cord injury is a kind of serious wound, the annual case that a lot of spinal cord injury are all arranged, and the increase year by year of case number, and therefore, spinal cord injury is the problem of a serious threat human health, can not be ignored.But at present people also do not know the genesis mechanism of spinal cord injury and treatment means etc., so that the treatment of spinal cord injury remains a global difficult problem.
For mechanism, the pathological change of excellent research spinal cord injury,, need set up standard, ideal animal experimental model in order to seek effective spinal cord injury treatment means.At present, artificial damage mode is adopted in the animal injury experiment mostly, for example artificially uses cross-section, the half cross-section spinal cord of blade; The manual release counterweight hits spinal cord, but these methods all are difficult to damage location is accurately located and quantified controlling, and mix operator's error easily, make that result reliability is poor, experiment is repeatable poor, thereby also just influenced the progress of spinal cord injury research.
Summary of the invention
The purpose of this invention is to provide a kind of device that can cause injury of laboratory animal with quantitatively locating.
The device that causes injury of laboratory animal provided by the present invention comprises platform and the height adjuster that is positioned on the platform, and it is characterized in that: described device also comprises beat component, horizontal stand and vertical rack;
Described beat component comprises striking bar, attacking head, guide pipe, electric magnet, power supply and switch; Described guide pipe is the hollow pipe of both ends open, is vertically fixed on the described horizontal stand; Described striking bar is sheathed in the guide pipe, and matched in clearance with it; Described striking bar one end links to each other with described attacking head, and the other end is made by ferrimagnet, and is arranged in the magnetic field that described electric magnet produces; Described electric magnet, power supply and switch are electrically connected;
Described height adjuster all is connected with described horizontal stand is vertical with described vertical rack; Described electric magnet is fixed on the described vertical rack.
Described striking bar is selected from the disposable standby striking bar group cover of weight; Described attacking head is selected from the standby attacking head group cover that shape variable changes; Described guide pipe is selected from the disposable standby guide pipe group cover of caliber.
Described ferrimagnet is ferrum or iron-nickel alloy.
Described device also comprises the prompting assembly that highly makes zero, and described height makes zero and reminds assembly to comprise display lamp, power supply and two conductive clamps of electrical connection; Described attacking head is made by conducting metal.
Described device also comprises the digit counter that is electrically connected with described height adjuster.
Described device also comprises the animal fixation kit, and described animal fixation kit comprises vertebra fixation part, stationary member bracket and vertical support column; Described vertical support column is connected on the described platform, and described stationary member bracket is sheathed on the described vertical support column; Described vertebra fixation part is plugged on the described stationary member bracket; The shape and the described shape of damaging animal of waiting with waiting to damage the end that the animal vertebra contacts of described vertebra fixation part are complementary.
Described animal fixation kit comprises the hole that is positioned on the described platform, fixed strip.
Described height adjuster and described platform are slidingly connected.
On the described platform level indicator is installed.
The present invention has utilized the freely falling body principle, adsorbs/discharge striking bar by galvanomagnetic-effect, has realized tissue injury's mechanization, and it is minimum that artificial disturbance is reduced to; The design of Different Weight striking bar, and the setting of highly make zero prompting assembly and height adjuster are regulated striking bar weight and drop height, and then have also just been regulated hitting dynamics, make damage reach quantified controlling; The prompting assembly that highly makes zero makes the location of hitting the position more accurate; The minute movement that animal heart beating when having got rid of strike is set, breathes the tissue that causes of fixation kit, the resting state of tissue when having guaranteed to hit.The present invention is suitable for the damage of the different tissues of all size animals such as monkey Mus, as spinal cord injury, brain tissue impairment etc.
The present invention has overcome the deficiency of animal tissue's damage model in the prior art, has realized fixed point, the amount damage of animal tissue, and practicable mechanized operation, has significantly reduced personal error, makes the repeatability of experiment stronger.The present invention also has advantage simple in structure, easy to operate, with low cost in addition.
Animal spinal cord damage model by the present invention's making, can simulate clinical spinal cord injury situation, can stablely obtain the situation of spinal cord injury, function of nervous system's infringement and the histo pathological change of different stage, help the research of clinical spinal cord injury Mechanism Study and drug test.This device repeatability is high, is the device that can clearly cause various spinal function obstacle threshold values.
Description of drawings
Fig. 1 is the perspective view of apparatus of the present invention.
Fig. 2 is the structural representation of platform among the present invention.
Fig. 3 reminds the circuit diagram of assembly for highly making zero.
Fig. 4 is the structural representation of platform top mounting subassembly.
The specific embodiment
As shown in Figure 1, Figure 2, Figure 3 and Figure 4, the structure of apparatus of the present invention is as follows:
This device comprises platform 1, height adjuster 2, beat component, horizontal stand 3 and vertical rack 4; Height adjuster 2 is vertically connected on the platform 1 by slide rail 18 and can moves freely on platform, and horizontal stand 3 is vertically connected on the height adjuster 2, and vertical rack 4 is vertically fixed on the horizontal stand 3;
Beat component comprises striking bar 5, copper attacking head 6, guide pipe 7, electric magnet 8, power supply and switch 9; Electric magnet 8 is fixed on the vertical rack 4; Electric magnet 8, power supply and switch 9 are electrically connected; Guide pipe 7 is the hollow pipe of both ends open, is vertically fixed on the horizontal stand 3; Striking bar 5 is sheathed in the guide pipe 7, and with it matched in clearance (be the internal diameter of guide pipe and striking bar diameter very near and guarantee that striking bar can pass guide pipe under the effect of gravity); Striking bar 5 one ends link to each other with attacking head 6; After electric magnet 8 was by logical powering on, an end (irony solid) relative with connecting that end of attacking head of striking bar 5 was attracted on the electric magnet under the effect of magnetic field force;
This device also contains highly to make zero to be reminded assembly, digit counter 12, animal fixation kit and is installed in level indicator on the platform 1;
Described height makes zero and reminds assembly to comprise bulb 10, power supply and two conductive clamps 11 of electrical connection;
Described animal fixation kit comprises hole 13, rigid plastics fixed strip 14, vertebra fixation part 15, vertical support column 16 and the stationary member bracket 19 that is positioned on the platform 1; Being complementary of vertebra fixation part 15 with the shape of the shape of waiting to damage the end that the animal vertebra contacts with the vertebra of waiting to damage animal; Vertically support column 16 is by hole 13 and vertical connection of platform 1 spiral, and stationary member bracket 19 is sheathed on outside the vertical support column 16 and its Height Adjustable on vertical support column 16, and vertebra fixation part 15 is plugged on the stationary member bracket 19.
Electric magnet is to be made of iron core and coil of being wound in around it, and described iron core specifically can be soft iron.
Wherein, can be used in different animals in order to make apparatus of the present invention, the modeling of different parts can be prepared several attacking heads that one group of shape variable changes.The shape of attacking head matches with the shape of being hit animal tissue, as concave structure or laminated structure etc.In actual applications, select and treat that the attacking head that laboratory animal is complementary gets final product;
Equally, striking bar also can for weight disposable several, select the striking bar of Different Weight according to the hitting dynamics that will realize, specifically can wait the striking bar of making Different Weight by diameter, length and the material that changes striking bar;
Apparatus of the present invention camber makes zero and reminds the action principle of assembly as follows: a conductive clamp is clipped on the attacking head, with another conductive clamp be clipped in wait to damage animal tissue near, when attacking head has just touched when waiting to damage animal tissue, power supply, bulb 10, be clipped in conductive clamp, attacking head, the animal tissue 20 on the attacking head and the conductive clamp that is clipped on the animal can form a closed circuit, the height RZ system starts, bulb can be bright, showing that attacking head has been aimed at waits to hit the zone, can with this moment attacking head height be designated as 0;
During use, the beat component in this device is a structure as mentioned above, when not using, can be with striking bar 5, attacking head 6, vertebra fixation part 15, vertically support column 16 and stationary member bracket 19 disassemble respectively, and leave in the packing box.
The application mode of apparatus of the present invention is as follows:
Complete disconnected spinal cord injury with realization monkey 600gcm is example.
Before the experiment, the experimental monkey groups of handling is placed on the platform 1, regulate level indicator and make the platform level, live the monkey body and the band two ends are separately fixed on the hole 13 with 14 bindings of fixing band, then according to the size of animal, both sides animal tighten vertical support column 16 in aperture 13, vertebra fixation part 15 is plugged on the stationary member bracket 19, and then stationary member bracket 19 is set in outside the vertical support column 16, according to the altitude mixture control support 19 of the prostrate vertebra of animal on support column 16 the position and screw, make the firm vertebra of vertebra fixation part 15 pincers.
Attacking head is connected on the striking bar, and makes striking bar pass guide pipe 7; Press switch 9, make electric magnet 8 produce magnetic field force, striking bar is adsorbed on the iron core; Conductive clamp 11 of folder on attacking head again, simultaneously monkey be damaged spinal cord near another conductive clamp 11 on the folder; Slip slide rail 18 is adjusted the position of attacking head, make attacking head 6 over against wanting the Spinal Cord zone, regulate the height of attacking head 6 again by turn height adjuster 2, slowly treat damage zone near spinal cord, when attacking head 6 contact damages zone, power supply, bulb 10, be clipped in conductive clamp, the attacking head on the attacking head and the conductive clamp that is clipped on the monkey body can form a closed circuit, the height zero-setting system starts, bulb can be bright, press the button 17 that makes zero on the digit counter 12 this moment, and making its display digit is 0; Then conductive clamp is removed, re-adjustment height adjuster 2, and then drive the height that increases striking bar 5 by horizontal stand 3, and show 30cm up to digit counter 12, stop to regulate height adjuster 2; Close switch 9, magnetic disappears, and striking bar is done the movement of falling object, hits the monkey spinal cord with the hitting dynamics of 600gcm, and striking bar is removed together with attacking head, promptly finishes the damage of quantitative location.
This device also is suitable for the damage of the different tissues of all size animals such as Mus, as spinal cord injury, brain tissue impairment etc.Specifically can be by the position of regulating fixation kit and accurate location and the amount damage that highly waits the fixing and strike that realizes animal.
Claims (9)
1, a kind of device that causes injury of laboratory animal comprises platform and the height adjuster that is positioned on the platform, and it is characterized in that: described device also comprises beat component, horizontal stand and vertical rack;
Described beat component comprises striking bar, attacking head, guide pipe, electric magnet, power supply and switch; Described guide pipe is the hollow pipe of both ends open, is vertically fixed on the described horizontal stand; Described striking bar is sheathed in the guide pipe, and matched in clearance with it; Described striking bar one end links to each other with described attacking head, and the other end is made by ferrimagnet, and is arranged in the magnetic field that described electric magnet produces; Described electric magnet, power supply and switch are electrically connected;
Described height adjuster all is connected with described horizontal stand is vertical with described vertical rack; Described electric magnet is fixed on the described vertical rack.
2, device according to claim 1 is characterized in that: described striking bar is selected from the disposable standby striking bar group cover of weight; Described attacking head is selected from the standby attacking head group cover that shape variable changes; Described guide pipe is selected from the disposable standby guide pipe group cover of caliber.
3, device according to claim 1 and 2 is characterized in that: described ferrimagnet is ferrum or iron-nickel alloy.
4, device according to claim 1 and 2 is characterized in that: described device also comprises the prompting assembly that highly makes zero, and described height makes zero and reminds assembly to comprise display lamp, power supply and two conductive clamps of electrical connection; Described attacking head is made by conducting metal.
5, device according to claim 1 and 2 is characterized in that: described device also comprises the digit counter that is electrically connected with described height adjuster.
6, device according to claim 1 and 2 is characterized in that: described device also comprises the animal fixation kit, and described animal fixation kit comprises vertebra fixation part, stationary member bracket and vertical support column; Described vertical support column is connected on the described platform, and described stationary member bracket is sheathed on the described vertical support column; Described vertebra fixation part is plugged on the described stationary member bracket; The shape and the described shape of damaging animal of waiting with waiting to damage the end that the animal vertebra contacts of described vertebra fixation part are complementary.
7, device according to claim 6 is characterized in that: described animal fixation kit comprises the hole that is positioned on the described platform, fixed strip.
8, device according to claim 1 and 2 is characterized in that: described height adjuster and described platform are slidingly connected.
9, device according to claim 1 and 2 is characterized in that: on the described platform level indicator is installed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008102223441A CN101375810B (en) | 2008-09-17 | 2008-09-17 | Device for causing injury of laboratory animal |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008102223441A CN101375810B (en) | 2008-09-17 | 2008-09-17 | Device for causing injury of laboratory animal |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101375810A true CN101375810A (en) | 2009-03-04 |
| CN101375810B CN101375810B (en) | 2010-07-21 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008102223441A Expired - Fee Related CN101375810B (en) | 2008-09-17 | 2008-09-17 | Device for causing injury of laboratory animal |
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| CN (1) | CN101375810B (en) |
Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101836904A (en) * | 2010-05-10 | 2010-09-22 | 大连医科大学 | Quantitative falling instrument for laboratory mice |
| CN102222441A (en) * | 2011-06-30 | 2011-10-19 | 中国人民解放军第三军医大学第三附属医院 | Blunt force injury causing simulator |
| CN102670324A (en) * | 2012-06-15 | 2012-09-19 | 中国人民解放军第四军医大学 | High-precision injury device for animal experiment |
| CN102688109A (en) * | 2012-06-15 | 2012-09-26 | 中国人民解放军第四军医大学 | Operation platform for laboratory animal |
| CN102772258A (en) * | 2012-07-27 | 2012-11-14 | 朱亚中 | Nerve panting clamp |
| CN103083108A (en) * | 2013-01-29 | 2013-05-08 | 北京大学第三医院 | Spinal cord mechanical compression device |
| CN103142326A (en) * | 2012-12-14 | 2013-06-12 | 中国科学院自动化研究所 | Electrical control system used for zooperal ventral spinal cord injury impactor |
| CN103505300A (en) * | 2013-09-29 | 2014-01-15 | 四川大学华西医院 | Rat acceleration and deceleration brain trauma striking system |
| CN104739537A (en) * | 2015-04-03 | 2015-07-01 | 绍兴文理学院 | Animal spinal cord injury hitting device |
| CN105708579A (en) * | 2016-01-21 | 2016-06-29 | 中南大学湘雅三医院 | Domestic rabbit traumatic osteoarthritis model making device |
| CN105769372A (en) * | 2016-03-16 | 2016-07-20 | 上海中医药大学附属普陀医院 | Wind-cold-dampness arthralgia type knee osteoarthritis model building method and device and use method |
| CN105963042A (en) * | 2016-05-09 | 2016-09-28 | 中国航天员科研训练中心 | Experiment seat used under electromagnetic radiation environment |
| WO2016197562A1 (en) * | 2015-06-12 | 2016-12-15 | 王业杨 | Animal spinal cord injury punching equipment |
| CN106691619A (en) * | 2017-02-22 | 2017-05-24 | 中南大学 | Impactor for animal spinal cord contusion |
| CN108403246A (en) * | 2018-01-18 | 2018-08-17 | 深圳市瑞沃德生命科技有限公司 | A kind of electric resistance partial pressure detection circuit and damage beating device |
| CN110169839A (en) * | 2019-05-29 | 2019-08-27 | 上海塔望智能科技有限公司 | A kind of animal spinal cord injury test macro |
| CN112869905A (en) * | 2020-12-31 | 2021-06-01 | 温州医科大学附属眼视光医院 | Electromagnetic quantitative striking device |
| CN113739683A (en) * | 2021-11-08 | 2021-12-03 | 深圳市瑞沃德生命科技有限公司 | Zero calibration device, striker with zero calibration device, zero calibration method and striking method |
Families Citing this family (1)
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| CN102760371B (en) * | 2011-04-26 | 2014-03-12 | 中国人民解放军沈阳军区总医院 | Big animal organ injury molding device |
-
2008
- 2008-09-17 CN CN2008102223441A patent/CN101375810B/en not_active Expired - Fee Related
Cited By (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101836904B (en) * | 2010-05-10 | 2013-10-30 | 大连医科大学 | Quantitative falling instrument for laboratory mice |
| CN101836904A (en) * | 2010-05-10 | 2010-09-22 | 大连医科大学 | Quantitative falling instrument for laboratory mice |
| CN102222441A (en) * | 2011-06-30 | 2011-10-19 | 中国人民解放军第三军医大学第三附属医院 | Blunt force injury causing simulator |
| CN102670324A (en) * | 2012-06-15 | 2012-09-19 | 中国人民解放军第四军医大学 | High-precision injury device for animal experiment |
| CN102688109A (en) * | 2012-06-15 | 2012-09-26 | 中国人民解放军第四军医大学 | Operation platform for laboratory animal |
| CN102772258A (en) * | 2012-07-27 | 2012-11-14 | 朱亚中 | Nerve panting clamp |
| CN103142326A (en) * | 2012-12-14 | 2013-06-12 | 中国科学院自动化研究所 | Electrical control system used for zooperal ventral spinal cord injury impactor |
| CN103142326B (en) * | 2012-12-14 | 2015-01-07 | 中国科学院自动化研究所 | Electrical control system used for zooperal ventral spinal cord injury impactor |
| CN103083108B (en) * | 2013-01-29 | 2015-05-20 | 北京大学第三医院 | Spinal cord mechanical compression device |
| CN103083108A (en) * | 2013-01-29 | 2013-05-08 | 北京大学第三医院 | Spinal cord mechanical compression device |
| CN103505300A (en) * | 2013-09-29 | 2014-01-15 | 四川大学华西医院 | Rat acceleration and deceleration brain trauma striking system |
| CN104739537A (en) * | 2015-04-03 | 2015-07-01 | 绍兴文理学院 | Animal spinal cord injury hitting device |
| WO2016197562A1 (en) * | 2015-06-12 | 2016-12-15 | 王业杨 | Animal spinal cord injury punching equipment |
| CN105708579A (en) * | 2016-01-21 | 2016-06-29 | 中南大学湘雅三医院 | Domestic rabbit traumatic osteoarthritis model making device |
| CN105708579B (en) * | 2016-01-21 | 2017-07-25 | 中南大学湘雅三医院 | Rabbit osteoarthritis after traumatic modelling device |
| CN105769372A (en) * | 2016-03-16 | 2016-07-20 | 上海中医药大学附属普陀医院 | Wind-cold-dampness arthralgia type knee osteoarthritis model building method and device and use method |
| CN105963042A (en) * | 2016-05-09 | 2016-09-28 | 中国航天员科研训练中心 | Experiment seat used under electromagnetic radiation environment |
| CN106691619A (en) * | 2017-02-22 | 2017-05-24 | 中南大学 | Impactor for animal spinal cord contusion |
| CN106691619B (en) * | 2017-02-22 | 2019-02-19 | 中南大学 | A kind of animal contusion of spinal cord ram |
| CN108403246A (en) * | 2018-01-18 | 2018-08-17 | 深圳市瑞沃德生命科技有限公司 | A kind of electric resistance partial pressure detection circuit and damage beating device |
| CN110169839A (en) * | 2019-05-29 | 2019-08-27 | 上海塔望智能科技有限公司 | A kind of animal spinal cord injury test macro |
| CN112869905A (en) * | 2020-12-31 | 2021-06-01 | 温州医科大学附属眼视光医院 | Electromagnetic quantitative striking device |
| CN113739683A (en) * | 2021-11-08 | 2021-12-03 | 深圳市瑞沃德生命科技有限公司 | Zero calibration device, striker with zero calibration device, zero calibration method and striking method |
| CN113739683B (en) * | 2021-11-08 | 2022-03-15 | 深圳市瑞沃德生命科技有限公司 | Zero calibration device, striker with zero calibration device, zero calibration method and striking method |
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| CN101375810B (en) | 2010-07-21 |
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