CN101373695B - Method and apparatus for observing and controlling digital ion trap - Google Patents
Method and apparatus for observing and controlling digital ion trap Download PDFInfo
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- CN101373695B CN101373695B CN200710045190A CN200710045190A CN101373695B CN 101373695 B CN101373695 B CN 101373695B CN 200710045190 A CN200710045190 A CN 200710045190A CN 200710045190 A CN200710045190 A CN 200710045190A CN 101373695 B CN101373695 B CN 101373695B
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Abstract
The invention discloses a method and a device for measuring and controlling a digital ion trap to generate and provide at least one phase high voltage rectangular wave driving voltage. The method comprises the following steps: generating a digital signal; and controlling a high voltage switch circuit by using the digital signal. The high voltage switch circuit comprises two switch blocks which are in series connection between a high voltage source and a low voltage source; the two switch blocks are controlled by the digital signal to be alternatively conducted or cut off, so as to enable the high voltage switch circuit to switch between the high voltage and the low voltage to generate a high voltage rectangular wave; each switch block comprises a plurality of switches in series connection; the plurality of switches of each switch block are controlled by the digital signal to be simultaneously conducted or cut off. The method and the device can be used for a two-dimensional linear ion trap and a three-dimensional rotation ion trap, so as to improve the resolution thereof and reduce the interference of high voltage.
Description
Technical field
The present invention relates to the technology of coming ion is carried out mass spectral analysis with ion trap, relate in particular to the investigating method and the device of digital ion trap.
Background technology
Traditional quadrupole field ion trap technology has had very great development since the fifties, be used in the mass spectrometer widely.The document of this respect and patent have and much are incorporated in " Practical Aspects of Ion Trap Mass Spectrometry " book that R.E.March and J.F.J.Todd writes.The basic utilization characteristics of ion trap mass spectrometry are: form an analysis space with the three-dimensional rotation ion trap, on ring electrode, add the radio frequency sine voltage and produce quadrupole field confinement ion, and between two end caps, add one two utmost point alternating voltage excited ion, discharge ion selectively.
1999, application population power proposed with one group of switch drive quadrupole field and then realization mass spectral analysis method (WO 0129875A, PCT/GB00/03964).In the method, pair of switches is connected between high level and the low level, alternately deciliter, producing a square-wave voltage outputs on the ring electrode of three-dimensional rotation ion trap, and further between two end caps, add one two utmost point alternating voltage, make ion selectively realize resonant excitation, reach the purpose of mass scanning by the quality size.
Two dimension straight line ion trap because of its big capacity, highly sensitive advantage, has been accepted by users since its commercialization, and is sinusoidal wave as driving voltage but present two-dimentional straight line ion trap adopts at large.If digital ion trap technology and two-dimentional straight line ion trap that Switching Power Supply is driven combine and will analytical performance further be improved.Though patent documentation WO 0129875A has also mentioned the method that applies digital voltage on two-dimentional linear ion trap,, do not disclose how from the straight line ion trap, to draw ion and detect effectively.
Though digital ion trap can be realized the ion analysis of quality greatly by enough less voltage magnitudes by scanning frequency (cycle), that is to say under limited fixed voltage, upwards the scan period can scan out the ion of high m/z, but low driving voltage means low effective potential well degree of depth, thereby reduction resolution, also can influence the collision energy when being MS-MS, and then reduce dissociation efficiency.So the high-voltage digital ripple is the key that realizes the high-efficiency digital ion trap.And single transistor (or other switching tubes) is withstand voltage limited, switches as switch with pair of transistor to be not enough to provide high drive voltage.
As everyone knows, the high-frequency and high-voltage that drives quadrupole field is harassed the sensitivity that influences instrument through regular meeting to the signal of detector.Under the situation of two-dimentional straight line ion trap, generally on x and y axial electrode, apply anti-phase each other driving voltage.If ion is outgoing in the slit from the x electrode, detector must be installed in x electrode one side.High frequency voltage in the x electrode will be scurried in the signal of detector at an easy rate, and making in the ion flow signal of output has very big noise.Though, at (Anal.Chem.2004 such as Ou Yangzheng " Rectilinear Ion Trap:Concepts; Calculations; and Analytical Performance of a New Mass Analyzer ", 76,4595-4605) in the literary composition, radio-frequency driven voltage only is added on the Y-axis electrode, and on the x electrode, only add two a very little utmost point excitation voltages, ion trap also can be worked, but this trap has a very big high frequency shaft potential, and the efficient of introducing ion vertically can be very low, only is suitable for the ionogenic working method of inner EI.If on the x of ion trap electrode, also apply switching voltage, radio-frequency component wherein will more easily be scurried in the detector circuit, making in the ion flow signal of output has very big digital noise, so the straight line digital ion trap also will solve a problem that reduces digital noise.
Summary of the invention
Technical problem to be solved by this invention provides a kind of investigating method and device of digital ion trap, to produce high pressure square drive voltage.
The present invention solves the problems of the technologies described above the investigating method that the technical scheme that adopts is a kind of digital ion trap of proposition, comprising: produce digital signal; Utilize this Digital Signals high voltage switch circuit, this high voltage switch circuit comprises two groups of switches set of connecting mutually that are connected between the high and low voltage source, this two switches set is subjected to this Digital Signals and alternate conduction and disconnection, and this high voltage switch circuit is switched between a high voltage and a low-voltage to produce the high pressure square wave; Wherein each switches set comprises the switch of a plurality of series connection, and a plurality of switches in each switches set are subjected to this Digital Signals and conducting simultaneously and disconnection.
In said method, the switches set that the switch of a plurality of series connection is formed can provide the output of high pressure square wave.In addition, the present invention has designed the mode that the ion flow signal of above-mentioned ion trap is sampled of being suitable for, promptly when the ion outgoing, obtain the ion flow signal, generation one and this digital signal have the sampled signal of fixed phase difference, with the moment of this sampled signal control ion flow signal sampling, make it synchronous, and avoid high voltage switch circuit and disturb the spike position that causes with the setting phase point of this high pressure square wave.
On the other hand, the invention provides a kind of measure and control device of digital ion trap, comprising: digital signal generator, in order to produce digital signal; High voltage switch circuit, it comprises two groups of switches set of connecting mutually that are connected between the high and low voltage source, wherein each switches set comprises the switch of a plurality of series connection, these a plurality of switches are subjected to described Digital Signals and conducting simultaneously and disconnection, make this two switches set alternate conduction and disconnection, and then this high voltage switch circuit is switched between a high voltage and a low-voltage to produce the high pressure square wave.
The digital ion trap that the present invention relates to can be a three-dimensional ion trap, also can be the linear pattern two-dimensional ion trap.
In sum, the investigating method of digital ion trap of the present invention and device, the implementation of the digital ion trap of one cover is provided, on the one hand, high-voltage switch gear by Digital Signals produces high pressure square drive voltage, improves resolution, on the other hand, in testing circuit, limit sampling phase, disturb to reduce high-voltage switch gear with pulse signal.Therefore, can make digital ion trap, the analytical performance of especially two-dimentional straight line ion trap gets a promotion.
Description of drawings
For above-mentioned purpose of the present invention, feature and advantage can be become apparent, below in conjunction with accompanying drawing the specific embodiment of the present invention is elaborated, wherein:
Fig. 1 is a digital ion trap spectrometer system schematic diagram according to an embodiment of the invention.
Fig. 2 is an embodiment who is used to produce the switches set of digital ion trap high voltage pulse.
Fig. 3 is another embodiment that is used to produce the switches set of digital ion trap high voltage pulse.
Fig. 4 is high pressure square wave output of the present invention and phase-locked sample circuit schematic diagram.
Fig. 5 is a kind of sampling instant schematic diagram of phase-locked sample circuit shown in Figure 4.
Fig. 6 is the another kind of sampling instant schematic diagram of phase-locked sample circuit shown in Figure 4.
Embodiment
Referring now to above-mentioned schematic view illustrating embodiment of the present invention.
Fig. 1 is a digital ion trap spectrometer system schematic diagram according to an embodiment of the invention.Please refer to shown in Figure 1ly, the digital ion trap mass spectrometer comprises electric spray ion source 1, heated capillary ion introducer 2, vacuum chamber 3,15, ion lens system 4, linear ion trap 8～10 and detector 11 and switching circuit 12, sample circuit 13 and the digital signal generator 14 that places atmospheric environment.Ion is transmitted by ion lens system 4 after capillary 2 is introduced first order low vacuum chamber 3.The ion lens system comprises two parts: the one, and the quadrupole field array 5, two in first order vacuum chamber 3, the quadrupole lens 6 in second level vacuum chamber 15.Two vacuum chambers 3,15 are separated by taper hole 7.Ion passes quadrupole field array 5, taper hole 7, lens 6 successively, enters analysis room 16 at last.In analysis room 16, the straight line ion trap is divided into three sections, and three sections cross sections are identical, and leading portion 8, back segment 9 are different with the DC potential of interlude 10.Ion trap shown in Figure 1 adopts four electrodes (being divided into 2 pairs, x, each 1 pair in the y direction) structure of hyperbolic cylinder, and the z axle is the bearing of trend (promptly axial) of straight line ion trap in addition.High-frequency alternating voltage on leading portion 8, the back segment 9 draws from interlude 10 by capacitive coupling.The effect of leading portion 8 and back segment 9 is to run out of from two ends at axial (being the z direction) restriction ion.In another embodiment, leading portion 8, back segment 9 also can be reduced to the end cap with two fixed potentials.In yet another embodiment, leading portion 8, stage casing 10 and back segment 9 all are made of insulation or the on-chip printed circuit of semi-conducting material.When introducing cation, the current potential on the leading portion 8 reduces earlier, and the direct voltage on the back segment 9 is gone up the current potential height than 10 in stage casing, wears the field and mistake with blocks ions.After ion entered the straight line ion trap, current potential on the leading portion 8 recovered high potential, and the ion interlude 10 that just is trapped in the straight line ion trap has suffered like this.Certainly a period of time after ion is introduced and introduced, ion will (≈ 10 with gas molecule in the trap
-1Pa) run foul of each other, its kinetic energy is descended, and then cool off, be focused into one section wire ion cloud near axis.
The following describes in order to control and to measure the measure and control device of above-mentioned ion trap.
The measure and control device of a kind of digital ion trap of the present invention comprises digital signal generator 14 and high voltage switch circuit 12.Digital signal generator 14 is in order to produce digital signal, and in one aspect, digital signal is as the control signal of high voltage switch circuit.Each high voltage switch circuit 12 that is used to export a phase driving voltage comprises two groups of switches set of connecting mutually that are connected between the high and low voltage source, wherein each switches set comprises the switch of a plurality of series connection, these a plurality of switches are subjected to described Digital Signals and conducting simultaneously and disconnection, make this two switches set alternate conduction and disconnection, and then this high voltage switch circuit is switched between-a high voltage and a low-voltage to produce the high pressure square wave.The switches set that these are in series by a plurality of switches can be born bigger voltage, and the driving voltage amplitude of high voltage switch circuit output is significantly promoted.
In Fig. 1, at the x of straight line ion trap, the driving voltage on two pairs of electrodes of y direction is produced by two high voltage switch circuits 121,122.See also shown in Figure 2ly, above-mentioned two pairs of electrodes are respectively electrode 21～24, and wherein electrode 21,22 is represented x direction electrode (being the first direction electrode) respectively, has ion lead-out groove 25 on it, are stimulated and outgoing for ion.Excitation voltage is provided by alternating source 211, and alternating source 211 is to be coupled between two x direction electrodes 21,22 through transformer 29.
Each switch element among Fig. 2 all can be made of a MOS switching tube, and wherein the type of drive of metal-oxide-semiconductor can realize with circuit shown in Figure 4.For simplicity's sake, only shown a high voltage switch circuit 121 among Fig. 4.Digital controlled signal generator 14, time sequential pulse digital signal Ck1, the Ck2 of generation two-way out-phase deliver to drive circuit 42 and 43 respectively.The high frequency low voltage pulse of drive circuit 42 outputs is delivered to each MOS transistor 46 by each isolating transformer 441.Certainly the output at isolating transformer 441 keeps device 45 to waveform shaping or level can be set respectively between the metal-oxide-semiconductor grid, so that opening and closing level and can both stablize in range of scanned frequencies necessarily on the transistor gate.As shown in Figure 4, last switches set and following switches set have respectively been used two MOS switching tubes 46 or 47, so that the voltage ratio that switch chain can bear is wanted height when using single metal-oxide-semiconductor.Certainly in order to bear higher voltage, also can use more metal-oxide-semiconductor, form longer switch chain.In addition, the resistance 48,49 of some low resistance of on switch chain, also can connecting, they play the effect of restriction metal-oxide-semiconductor firing current, have also born the power consumption of part metal-oxide-semiconductor.In an embodiment of the present invention, these resistance 48,49 adopt the good resistor of heat dispersion, such as the high-power planar ceramic resistor.
The two ways of digital signals Ck1 that digital signal generator 14 is sent, Ck2 send to the transistor 46 that will guarantee after the metal-oxide-semiconductor in the switches set and transistor 47 in the following switches set and replace deciliter.For instance, each MOS transistor (as transistor 46) all is subjected to digital signal Ck1 control and conducting simultaneously and disconnection in each group high-voltage switch gear, and each MOS transistor (as transistor 47) in another group high-voltage switch gear must just be subjected to digital signal Ck2 control and all conductings when the transistor in the last group of high-voltage switch gear (as transistor 46) disconnects, and is subjected to digital signal Ck2 control before the transistor in last group of high-voltage switch gear (as the transistor 46) closure and whole the disconnection.This can easily realize by adjusting digital signal Ck1, the rising edge of Ck2 and the time-delay between the trailing edge.Switching circuit 121 shown in Figure 4 provides to the driving voltage of x direction electrode, and provides control signal Ck3, the Ck4 of switching circuit 122 of the driving voltage of y direction electrode also will be provided by digital signal generator 14.Control signal Ck3 is the signal of switches set on the control second switch circuit 122, it and the control signal Ck2 same-phase of the following switches set switch of first switching circuit 121, so can share.Equally, control signal Ck4 is the signal of control second switch circuit 122 times switches set, and the control signal Ck1 same-phase of the last switches set switch of it and first switching circuit 121 can be shared.Control switch group like this, then the voltage on the x electrode will be just in time opposite with the polarity of voltage on the y electrode.
In one embodiment, digital signal Ck1～Ck4 is handled and produces through frequency division, time-delay etc. by a basic clock signal CLK in digital signal generator 14.
Get back to shown in Figure 2, if the absolute value of voltage of two high voltage source HV in first, second switching circuit 121,122 is just in time identical, then the ac potential of the field axle point O of straight line ion trap is zero, therefore the ion trap that has very big high frequency shaft potential in compared to existing technology, adopt measure and control device of the present invention, will efficient that introduce ion vertically be improved.
From simplifying the angle of power supply, one among the high voltage source HV at first, second switching circuit 121,122 two ends can change ground connection into, and this method of attachment as shown in Figure 3.Because the output of switching circuit alternately is connected between zero potential and the positive high voltage, the square wave of output has been Duoed a positive bias than the embodiment of Fig. 2, and size is HV/2.Correspondingly, a shaft potential positive bias too so coupled introducing lens 6 and detector 11 (Fig. 1) are also wanted positively biased, can be introduced and be drawn effectively to guarantee ion.
Describe below and reduce the method that high pressure disturbs in this device.
On the x-y of straight line ion trap electrode pair, add square-wave voltage, certainly will produce bigger interference detector circuit 11.Usually detector 11 is placed in (as shown in Figure 1) outside the x electrode, is subjected to the driving voltage of x electrode to disturb bigger.Fig. 5 has provided from rectangular pulse driving voltage 51 and has scurried interference signal waveform on the detector lead-in wire, and this waveform generally is rendered as the quick spike 52 at the rising/falling edge of driving voltage, and the shake of a period of time thereafter.When mass scanning, if adopt fixed sample rate to the analog-to-digital conversion of sampling of the output signal of detector, the frequency of spike signal 52 constantly changes with scanning so, the top and bottom of spike always has an opportunity to be adopted, in mass spectrum, present very big " noise ", if but the synchronous phase-locked sampling configuration (frequency-change sampling) in specific phase site of employing and rectangular wave drive voltage, just might find a more smooth phase place, as 59 indications of arrow among Fig. 5, as long as control sampling time-delay d, the rising edge and the trailing edge of phase point and rectangular wave drive voltage are staggered, just can guarantee not adopt the period of jumping in the signal, avoided " numeric type " to harass noise.
Please get back to shown in Figure 4, sample circuit 13 one side are through the continuous ion flow signal of amplifier 410 pick-up probes 11, receive sampled signal Syn on the other hand from digital signal generator 14, this sampled signal Syn can be produced by basic clock signal CLK, therefore will there be fixed phase difference in sampled signal Syn and digital signal Ck1～Ck4, and the ratio of their frequencies is integer, and in addition, this fixed skew can be adjusted.
In one embodiment, sampled signal Syn is configured to equate and constant phase difference with digital signal Ck1～Ck4 frequency.Because rectangular wave drive voltage is equally by Digital Signals, therefore sampled signal Syn can keep having constant time-delay d synchronously and with its trailing edge 53 with rectangular wave drive voltage, therefore be able to the ion flow signal be sampled, avoid spike 52,54 in sampling instant shown in Figure 5.
In conjunction with reference to figure 4 and Fig. 6, in actual applications, we may carry out filtering earlier with low pass filter (figure does not show) before 13 pairs of ion flow signal samplings of sample circuit, harass spike and might become slick and sly in filtered signal 63, just like the waveform of Fig. 6 middle and lower part.In this case, can produce sampled signal Syn 61 by digital signal generator 14, the frequency of sampled signal Syn 61 is set to twice and the constant phase difference of digital signal Ck1～Ck4, therefore in the cycle of each driving voltage 62, two trigger impulses that differ from 180 ° on phase place can be provided, make sampling occur on the specific time-delay point behind driving voltage rising edge and the trailing edge, that is to say, on two anti-phase points 64,65 of the fundamental frequency of disturbing wave 63, as shown in Figure 6.After analog-to-digital conversion, with average calculation unit 411 that above-mentioned double sampling value is average in addition, can farthest eliminate noise.Need to prove that low pass filter does not limit by independent device and realizes that some has the device of certain bandwidth, has promptly realized the function of low-pass filtering as amplifier 410.
Certainly, if sample rate is enough fast, also can be at each driving voltage more equally distributed phase point up-sampling in the cycle, be the frequency of sampled signal Syn be set to digital signal Ck1～Ck4 N doubly, control ion flow signal sampling is N time in each high pressure square wave cycle, phase intervals is the 360/N degree, gets its mean value then, and wherein N is the integer greater than 2.
It is worthy of note, though top be that example is described the method that this reduction high pressure disturbs with two-dimentional straight line ion trap, yet this method can be used in three-dimensional quadrupole ion equally.
In addition, the investigating method of a kind of digital ion trap proposed by the invention offers at least one phase high pressure rectangular wave drive voltage of ion trap in order to generation, may further comprise the steps:
Produce digital signal Ck, for example produce time sequential pulse with digital signal generator shown in Figure 4 14;
Utilize digital signal Ck control high voltage switch circuit, wherein this high voltage switch circuit comprises two groups of switches set of connecting mutually that are connected between the high and low voltage source, this two switches set alternate conduction and disconnection are switched to produce the high pressure square wave this high voltage switch circuit between a high voltage and a low-voltage; Wherein each switches set comprises the switch of a plurality of series connection, and a plurality of switches in each switches set are subjected to digital signal Ck control and conducting simultaneously and disconnection.
For instance, digital signal generator 14 produces digital signal Ck1, Ck2, behind drive circuit 42,43, isolating transformer 441,442, keep through level again, drive the switching circuit that each transistor 46,47 is formed then, make it alternately between positive voltage+HV and negative voltage-HV, to switch, thereby produce a high frequency square wave.
In one embodiment, said method can be used for driving straight line ion trap as shown in Figure 2, wherein, offer the x electrode pair of ion trap and the two-phase high pressure square wave of y electrode pair to produce respectively, and this two-phase high pressure square wave is anti-phase by two high voltage switch circuits of Digital Signals.These other details that drive process have been described in preamble, do not repeat them here.In addition, after having understood spirit of the present invention, those skilled in the art can be used to said method to drive three-dimensional four utmost points rotation ion trap easily, wherein by high voltage switch circuit of Digital Signals, offer the high pressure square wave of the ring electrode of ion trap with generation.
The investigating method of above-mentioned digital ion trap, also be included in ion scan when drawing with detector 11 sample ions stream signal, wherein produce a sampled signal Syn, with the moment of control ion flow signal sampling according to digital signal Ck.Because rectangular wave drive voltage is equally by digital signal Ck control, so sampled signal Syn can keep synchronously with rectangular wave drive voltage.And the determined sampling instant of sampled signal Syn meeting is synchronous with the setting phase point of high pressure square wave.The setting phase point of this high pressure square wave staggers with rising edge and trailing edge, so that spike shown in Figure 5 52,54 is avoided in sampling instant.
In addition, if comprising, the method for ion flow signal sampling earlier the ion flow signal is carried out low-pass filtering, so in sampling process, can in each high pressure square wave cycle, control ion flow signal sampling N time by sampled signal, phase intervals is the 360/N degree, wherein N is the positive integer greater than 1, gets its mean value then.For instance, as shown in Figure 6, can control ion flow signal sampling 2 times in each high pressure square wave cycle by sampled signal, wherein the phase difference of 2 sampling generations is 180 degree.Because the signal of 2 sampling gained is opposite, can offset the interference that each sampling may cause after therefore averaging.
In sum, the investigating method of digital ion trap of the present invention and device, the implementation of the digital ion trap of one cover is provided, on the one hand, high-voltage switch gear by Digital Signals produces high pressure square drive voltage, improves resolution, on the other hand, in testing circuit, limit sampling phase, disturb to reduce high-voltage switch gear with synchronization pulse.Therefore, can make digital ion trap, the analytical performance of especially two-dimentional straight line ion trap gets a promotion.
Though the present invention discloses as above with preferred embodiment; right its is not in order to qualification the present invention, any those skilled in the art, without departing from the spirit and scope of the present invention; when can doing a little modification and perfect, so protection scope of the present invention is when with being as the criterion that claims were defined.
Claims (18)
1. the investigating method of a digital ion trap offers the high pressure rectangular wave drive voltage of two pairs of electrodes of linear ion trap in order to generation, it is characterized in that described method comprises:
Produce digital signal;
Utilize two high voltage switch circuits of this Digital Signals, wherein each high voltage switch circuit comprises two groups of switches set of connecting mutually that are connected between the high and low voltage source, wherein each switches set comprises the switch of a plurality of series connection, a plurality of switches in each switches set are subjected to this Digital Signals and conducting simultaneously and disconnection, and this two switches set is subjected to this Digital Signals and alternate conduction and disconnection, and each high voltage switch circuit is switched between a high voltage and a low-voltage to produce a high pressure square wave mutually; Two high voltage switch circuits produce first electrode pair that offers ion trap and the two-phase high pressure square wave of second electrode pair respectively, and it is anti-phase with the second high pressure square wave that drives second electrode pair to drive the first high pressure square wave of first electrode pair.
2. the investigating method of digital ion trap according to claim 1 is characterized in that, each switch of each switches set is to be made of the MOS field-effect transistor.
3. the investigating method of digital ion trap according to claim 1 and 2 is characterized in that, this digital signal is to be coupled to each switch in the high voltage switch circuit via isolating transformer.
4. the investigating method of digital ion trap according to claim 1 is characterized in that, one of high and low voltage source that this high voltage switch circuit connected is a no-voltage.
5. the investigating method of digital ion trap according to claim 1 is characterized in that, the high and low voltage source that this high voltage switch circuit connected is respectively positive voltage source and negative voltage source, and the absolute value of voltage of the two is identical.
6. the investigating method of digital ion trap according to claim 1, it is characterized in that, first electrode pair of linear ion trap is vertical with the second electrode pair direction, have at least in first electrode pair on the electrode ion lead-out groove is arranged, and this method also comprises provides an excitation voltage between the described first direction electrode pair, makes the ion in this ion trap be stimulated the back by this ion lead-out groove outgoing.
7. the investigating method of digital ion trap according to claim 1 is characterized in that, also comprises:
When the ion outgoing, obtain the ion flow signal;
Generation one and this digital signal have the sampled signal of fixed phase difference, in the moment with this sampled signal control ion flow signal sampling, make it synchronous with the setting phase point of this high pressure square wave.
8. the investigating method of digital ion trap according to claim 7, it is characterized in that, this sampled signal is controlled ion flow signal sampling 1 time in each high pressure square wave cycle, and the setting phase point of this high pressure square wave staggers with this high pressure square wave rising edge and trailing edge.
9. the investigating method of digital ion trap according to claim 1 is characterized in that, also comprises:
When the ion outgoing, obtain the ion flow signal;
Generation one and this digital signal have the sampled signal of fixed phase difference, and this sampled signal is controlled ion flow signal sampling N time in each high pressure square wave cycle, and phase intervals is the 360/N degree, and N is the positive integer greater than 1;
Calculate the mean value of this N time sampling.
10. the measure and control device of a digital ion trap offers the high pressure rectangular wave drive voltage of two pairs of electrodes of ion trap in order to generation, it is characterized in that described device comprises:
Digital signal generator is in order to produce digital signal;
High voltage switch circuit, wherein each high voltage switch circuit comprises two groups of switches set of connecting mutually that are connected between the high and low voltage source, wherein each switches set comprises the switch of a plurality of series connection, a plurality of switches in each switches set are subjected to described Digital Signals and conducting simultaneously and disconnection, make this two switches set alternate conduction and disconnection, and then each high voltage switch circuit is switched between a high voltage and a low-voltage to produce a high pressure square wave mutually; Two high voltage switch circuits produce first electrode pair that offers ion trap and the two-phase high pressure square wave of second electrode pair respectively, and it is anti-phase with the second high pressure square wave that drives second electrode pair to drive the first high pressure square wave of first electrode pair.
11. the measure and control device of digital ion trap according to claim 10 is characterized in that, each switch of this each switches set is to be made of the MOS field-effect transistor.
12. the measure and control device according to claim 10 or 11 described digital ion traps is characterized in that, also comprises isolating transformer, in order to couple this digital signal each switch to the high-voltage switch gear circuit.
13. the measure and control device of digital ion trap according to claim 10, it is characterized in that, wherein first electrode pair of linear ion trap is vertical with the second electrode pair direction, have at least in first electrode pair on the electrode ion lead-out groove is arranged, and comprise a transformer, it couples an excitation voltage between this first direction electrode pair, makes the ion in the ion trap be stimulated the back by this ion lead-out groove outgoing.
14. the measure and control device of digital ion trap according to claim 10 is characterized in that, one of high and low voltage source that this high voltage switch circuit connected is a no-voltage.
15. the measure and control device of digital ion trap according to claim 10 is characterized in that, the high and low voltage source that this high voltage switch circuit connected is respectively positive voltage source and negative voltage source, and the absolute value of voltage of the two is identical.
16. the measure and control device of digital ion trap according to claim 10 is characterized in that, also comprises:
One detector is in order to obtain the ion flow signal when the ion outgoing;
One sample circuit, be connected to this detector and this digital signal generator, this sample circuit receives this ion flow signal from this detector, and this digital signal generator receives the sampled signal that fixed phase difference is arranged with described digital signal certainly, and, make it synchronous with the setting phase point of described high pressure square wave with the moment of this sampled signal control to this ion flow signal sampling.
17. the measure and control device of digital ion trap according to claim 16 is characterized in that, this sampled signal is controlled ion flow signal sampling 1 time in each high pressure square wave cycle, and the setting phase point of this high pressure square wave staggers with rising edge and trailing edge.
18. the measure and control device of digital ion trap according to claim 10 is characterized in that, also comprises:
One detector is in order to obtain the ion flow signal when the ion outgoing;
One sample circuit, be connected to this detector and this digital signal generator, this sample circuit receives this ion flow signal from this detector, and this digital signal generator receives the sampled signal that fixed phase difference is arranged with described digital signal certainly, this sampled signal is controlled ion flow signal sampling N time in each high pressure square wave cycle, phase intervals is the 360/N degree, and N is the positive integer greater than 1;
One average calculation unit is calculated the mean value of this N time sampling.
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| DE102011015595B8 (en) * | 2011-03-30 | 2015-01-29 | Krohne Messtechnik Gmbh | Method for controlling a synchronous ion shield mass separator |
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| CN104916520B (en) * | 2014-03-10 | 2018-06-22 | 芜湖谱实源仪器有限公司 | A kind of method for improving ion trap mass spectrometer low mass cut-off value |
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| US20230335388A1 (en) * | 2022-04-13 | 2023-10-19 | Shimadzu Corporation | Linear ion trap and method for operating the same |
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| CN1836308A (en) * | 2003-06-05 | 2006-09-20 | 岛津研究所（欧洲）有限公司 | A method for obtaining high accuracy mass spectra using an ion trap mass analyser and a method for determining and/or reducing chemical shift in mass analysis using an ion trap mass analyser |
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| CN1836308A (en) * | 2003-06-05 | 2006-09-20 | 岛津研究所（欧洲）有限公司 | A method for obtaining high accuracy mass spectra using an ion trap mass analyser and a method for determining and/or reducing chemical shift in mass analysis using an ion trap mass analyser |
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