CN101368942A - Dry sheet type fast detecting instrument - Google Patents
Dry sheet type fast detecting instrument Download PDFInfo
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- CN101368942A CN101368942A CNA2008101961867A CN200810196186A CN101368942A CN 101368942 A CN101368942 A CN 101368942A CN A2008101961867 A CNA2008101961867 A CN A2008101961867A CN 200810196186 A CN200810196186 A CN 200810196186A CN 101368942 A CN101368942 A CN 101368942A
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Abstract
The invention relates to a dry-plate rapid detector, belonging to the field of medical devices. The dry-plate rapid detector comprises optical detection components (a light source and a photosensor), an integrated circuit board (which integrates a light source drive circuit and a signal acquisition/amplifying circuit) micro-converter chip, a display device, a temperature control device, an IC card reader, a micro-printer, a communication device, a detection plate charging and discharging bin, and a shell. The dry-plate rapid detector can achieve quantitative or qualitative rapid detection of various biochemical indexes of human blood samples (whole blood, plasma, serum) and make a timely diagnosis on the related diseases; the dry-plate rapid detector is characterized by high degree of automation, rapid and accurate detection, stable performance, easy and simple operation, compact machine structure, smart appearance and easy carrying.
Description
Technical field
The present invention relates to a kind of dry sheet type fast detecting instrument.A kind ofly specifically can use supporting dry plate test board fast quantification or qualitatively finish the dry sheet type fast detecting instrument that multinomial biochemical indicator detects simultaneously.Belong to technical field of medical instruments.
Background technology
Medical test always is medical diagnosis on disease one of means the most accurately and effectively.In today that the medical test technical development is maked rapid progress, people can utilize current each subject advanced technology to serve clinical examination, timely and effectively disease are diagnosed.From last century end, the full automatic biochemical apparatus that people will integrate advanced technologies such as life science technology, electronic technology, computer technology is applied to the clinical biochemical check, has started the robotization road of biochemical project check.Yet, bulky because full automatic biochemical apparatus exists price high, once require specimen amount big, to the reagent requirement height, operate problems such as loaded down with trivial details relatively, cause it to popularize comprehensively.
Doing (biology) chemical detection technique is the novel biochemical inspection technology that development in recent years is got up.Do (biology) chemical detection technique and accepted, become the new force of clinical biochemical check routine and emergency treatment testing by clinical labororatory with its particular performances.Compare with classic method, have simple to operate, speed fast, pollute less, the result stablizes plurality of advantages such as accurate.Do the mode of (biology) chemical detection, normally will participate in each chemical reagent of reacting wiring solution-forming in proportion, add with the solid phase reaction carrier on, can be used for clinical detection after drying.In the testing process, dried (biology) chemical agent dissolves speed is fast, local concentration is high, reaction velocity is fast, simultaneously, can guarantee that some reagent maintain a long-term stability under solid dry material state.The reaction principle of dry chemical check mostly is chromogenic reaction, can be by based on optical sensor class detecting instrument, and gather change color and the light signal that produces, and be translated into electric signal, again through signal Processing, thereby realize the detection by quantitative of measured object.
At present, do (biology) chemical Fast Detection Technique and still belong to emerging technology in the clinical detection field, application at home and abroad is still very not extensive, is in the stage in the ascendant.
Summary of the invention
The purpose of this invention is to provide a kind of dry sheet type fast detecting instrument, the multifunctional dry plate test board of our invention of the supporting use of this detector, can realize that one-time detection finishes the detection of 1～4 (also can more expansions) biochemical indicator simultaneously, be less than 5 minutes detection time, required sample size is few, has improved detection efficiency greatly.
The said dry sheet type fast detecting instrument of the present invention is formed by being fixed in light source 1 in the casing 13, light activated element 2, integrated light source driving circuit 4 and surface-mounted integrated circuit 3, little converter chip 6, temperature control device 7, IC-card card reader 8, mini-printer 9, communication device 10, check-out console turnover storehouse 11, the variable-voltage power supply 14 of signals collecting/amplifying circuit 5 and the display device 12 that is embedded on the casing 13; Wherein mini-printer 9 exit slots are positioned at the casing surface, IC-card card reader 8 and check-out console turnover storehouse 11 have corresponding draw-in groove respectively on casing, light source 1 is fixed by rigidly fixing support with light activated element 2, become 15-45 degree angle, face the direction of its matching used dry plate test board (lie in during reaction check-out console turnover storehouse in) solid phase reaction carrier film, can accurately reflex on the light activated element after making illumination that light source sends on the carrier film.Light source driving circuit 4 and signals collecting/amplifying circuit 5 all are integrated on the surface-mounted integrated circuit 3, and are connected with light activated element 2 with light source 1 respectively, are embedded in little converter chip 6 connections on the surface-mounted integrated circuit 3 and are controlling each functional circuit.In addition, temperature control device 7, IC-card card reader 8, mini-printer 9, communication device 10, check-out console turnover storehouse 11 and display device 12 all link to each other with surface-mounted integrated circuit 3.Variable-voltage power supply 14 directly connects surface-mounted integrated circuit 3, temperature control device 7, IC-card card reader 8, mini-printer 9, is each parts power supply.
Above-mentioned said light source is the monochromatic source luminescent device, can be light emitting diode (LED), laser diode (LD) etc., its purpose is to produce the light with the specific wavelength that to react shown color suitable, shines the solid phase reaction carrier film of dry plate test board.
Light activated element can be light activated elements such as photoresistance, photodiode, its role is to receive the reflected light of light after the reflection of dry plate test board solid phase reaction carrier film that light source sends, and light signal is converted into electric signal.Light source and light activated element are fixed by rigidly fixing support, become 15-45 degree angle, face the direction of its matching used dry plate test board solid phase reaction carrier film, can accurately reflex on the light activated element after making illumination that light source sends on the carrier film.
The temperature control device comprises parts such as temperature-sensing element, electric heating sheets, lagging casing.Its effect is to guarantee that the chemical reaction on the solid phase reaction film carries out under constant temperature.As required, check-out console can be passed in and out that temperature in the storehouse is accurately constant to be controlled at 30～55 ℃.
Display device can be common light emitting diode or liquid crystal digital display etc.
Communication device comprises data line, communication interface (can be RS232 interface, USB interface etc.) etc., can connect the built-in miniature printer or external outer computer carries out data synchronization processing.
Casing can be hard materials such as plastics, metal.
IC-card card reader that dry sheet type fast detecting instrument of the present invention is built-in before detection is carried out, can read IC-card information automatically according to program design.By to write the mode of IC-card information, realized the transfer process between the different test items of same instrument, realized target multi-functional, robotization flexibly cleverly.IC-card has write down the offset information of corresponding batch dry plate test board simultaneously, has guaranteed the accuracy of testing result.
Cooperate dry sheet type fast detecting instrument of the present invention to use multifunctional dry plate test board, a plurality of solid phase reactions district is arranged, be preferably four, promptly install 1～4 relatively independent solid phase reaction carrier film on each multifunctional dry plate test board additional.Because the chemical reagent difference of being solidified in the solid phase reaction district, therefore, only need the liquid sample of bleeding to finish the detection of disparity items index simultaneously during clinical detection.More specifically, said multifunctional dry plate test board comprise the solid phase reaction carrier film of adsorbing biochemical reagents, carbon-fibre strips frame, upper strata with the supporting pad of thin glass paper, installed the rigid stent and the cushion of whole blood filter paper additional; The solid phase reaction carrier film is fixed on each window of carbon-fibre strips frame; The carbon-fibre strips frame is connected with rigid stent by the cushion that is fixed on the rigid stent two ends; Embedded loading slot in the middle of the rigid stent, the loading slot front end has the whole blood filter paper; Rigid stent is pasted with supporting pad near a side of solid phase reaction carrier film, and thin glass paper is arranged on the supporting pad.The whole blood filter paper can contact with thin glass paper when cushion is compressed, and thin simultaneously glass paper can contact with the solid phase reaction carrier film; Whole blood sample promptly is to realize separating of haemocyte and serum by the whole blood filter paper, and serum is transferred to thin glass paper and finally reaches on the solid phase reaction carrier film and biochemical reagents generation Indicator Reaction thereafter.
Its detection principle of dry sheet type fast detecting instrument is: by the change color on light source and the light activated element detection dry plate test board solid phase reaction carrier film, and light signal is converted into electric signal, through signals collecting/amplifying circuit, after the signal amplification, handle by logical operation by little converter chip, and testing result shown by display device, can report as a result be printed by the built-in miniature printer simultaneously.Wherein, signals such as color variance on the solid phase reaction film or change color speed, there is proportional relation in common and measured object concentration.So when little converter chip carries out the logical operation processing to photosignal, also can detect the difference of principle according to measured object, take Different Logic algorithms such as end-point method or rate method, calculate measured object concentration.
The application of dry sheet type fast detecting instrument comprises being used for fast quantification or qualitative detection blood sugar, blood fat (high-density lipoprotein (HDL), low-density lipoprotein, T-CHOL, triglyceride etc.), glutamic-pyruvic transaminase, glutamic-oxalacetic transaminease, hepatitis B surface antigen etc., renal function index (creatinine, urea nitrogen, total CO 2 and blood potassium) and part routine blood test index etc. clinically.Since product of the present invention have be swift in response, characteristics such as accuracy, precision height, many-sided requirements such as routine diagnosis, emergency treatment, the examination of blood source can be satisfied in using in the historical facts or anecdotes border.
The present invention relates to the detector product, it is designed and developed and the technology path science, rationally, high, the stable performance of automaticity, multiple functional, convenience is easy-to-use, outward appearance is small and exquisite, be easy to carry.Testing result accuracy height, good reproducibility, detection speed is fast, can satisfy the needs of extensive quick test on hospitals at different levels and the mobile blood-collecting carriage fully.
Description of drawings
Fig. 1 is an external structure synoptic diagram of the present invention.
Fig. 2 is an inner structure synoptic diagram of the present invention.
Fig. 3 is a principle of work synoptic diagram of the present invention.
The 1-light source; The 2-light activated element; The 3-surface-mounted integrated circuit; The 4-light source driving circuit; 5-signals collecting/amplifying circuit; The little converter chip of 6-; 7-temperature control device; The 8-IC card reader; The 9-mini-printer; The 10-communication device; 11-check-out console turnover storehouse; The 12-display device; The 13-casing; 14 variable-voltage power supplies.
Embodiment
As shown in Figure 1 to Figure 3, dry sheet type fast detecting instrument is formed by being fixed in light source 1 in the casing 13, light activated element 2, integrated light source driving circuit 4 and surface-mounted integrated circuit 3, little converter chip 6, temperature control device 7, IC-card card reader 8, mini-printer 9, communication device 10, check-out console turnover storehouse 11, the variable-voltage power supply 14 of signals collecting/amplifying circuit 5 and the display device 12 that is embedded on the casing 13; Wherein mini-printer 9 exit slots are positioned at the casing surface, IC-card card reader 8 and check-out console turnover storehouse 11 have corresponding draw-in groove respectively on casing, light source 1 is fixed by rigidly fixing support with light activated element 2, become 15-45 degree angle, face the direction of its matching used dry plate test board (lie in during reaction check-out console turnover storehouse in) solid phase reaction carrier film, can accurately reflex on the light activated element after making illumination that light source sends on the carrier film.Light source driving circuit 4 and signals collecting/amplifying circuit 5 all are integrated on the surface-mounted integrated circuit 3, and are connected with light activated element 2 with light source 1 respectively, are embedded in little converter chip 6 connections on the surface-mounted integrated circuit 3 and are controlling each functional circuit.In addition, temperature control device 7, IC-card card reader 8, mini-printer 9, communication device 10, check-out console turnover storehouse 11 and display device 12 all link to each other with surface-mounted integrated circuit 3.Variable-voltage power supply 14 directly connects surface-mounted integrated circuit 3, temperature control device 7, IC-card card reader 8, mini-printer 9, is each parts power supply.
Embodiment 1: the mensuration of alanine aminotransferase (ALT) vigor
Dry sheet type fast detecting instrument, light source 1 adopt light emitting diode, light activated element 2 to adopt common photodiode.Light source becomes 15 degree fixing with the photodiode angle.Detected temperatures is by chip controls, and constant temperature is at 30-45 ℃ ± 1 ℃.The built-in miniature printer installs liquid crystal digital display additional and fixes cabinet.IC-card writes ALT logical operation mode and corresponding batch ALT dry plate test board offset in advance.
Detect step:
1, start: instrument carries out self check, and carries out warming-up.
2, application of sample: get finger tip tip blood 35 μ l, in the loading slot of application of sample and ALT dry plate test board, be put in the dry sheet type fast detecting instrument check-out console turnover storehouse 11, press "start" button, begin to detect with being about to check-out console.
3, detect: the illumination of the specific wavelength that reflective diode sends is mapped on the solid phase reaction carrier film of ALT dry plate test board, and back reflection is to photodiode, the change color on the continuous monitoring film.Photodiode is converted into electric signal with light signal, and through signals collecting/amplifying circuit signal is amplified.Little converter chip calculates the ALT enzyme according to ALT logical operation mode and lives, and the result is presented on the liquid crystal digital display.
4, print: press " printing " key on the casing, it is single to print test results report automatically.
Embodiment 2: the mensuration of blood sugar, blood fat
Dry sheet type fast detecting instrument, light source 1 adopt light emitting diode, light activated element 2 to adopt common photodiode.Light source becomes 30 degree fixing with the photodiode angle.Detected temperatures is by chip controls, and constant temperature is at 30-45 ℃ ± 1 ℃.The built-in miniature printer installs liquid crystal digital display additional and fixes cabinet.IC-card writes blood sugar, blood fat logical operation mode and corresponding batch blood sugar, blood fat dry plate test board offset in advance.
Detect step:
1, start: instrument carries out self check, and carries out warming-up.
2, application of sample: get finger tip tip blood 35 μ l, in the loading slot of application of sample and blood sugar, blood fat dry plate test board, be put in the dry sheet type fast detecting instrument check-out console turnover storehouse 11, press "start" button, begin to detect with being about to check-out console.
3, detect: the illumination of the specific wavelength that reflective diode sends is mapped on the solid phase reaction carrier film of blood sugar, blood fat dry plate test board, and back reflection is to photodiode, the change color on the continuous monitoring film.Photodiode is converted into electric signal with light signal, and through signals collecting/amplifying circuit signal is amplified.Little converter chip calculates blood sugar, blood fat value according to blood sugar, blood fat logical operation mode, and the result is presented on the liquid crystal digital display.
4, print: press " printing " key on the casing, it is single to print test results report automatically.
Embodiment 3: the mensuration of renal function index (creatinine, urea nitrogen, total CO 2 and blood potassium)
Dry sheet type fast detecting instrument, light source 1 adopt light emitting diode, light activated element 2 to adopt common photodiode.Light source becomes 45 degree fixing with the photodiode angle.Detected temperatures is by chip controls, and constant temperature is at 30-45 ℃ ± 1 ℃.The built-in miniature printer installs liquid crystal digital display additional and fixes cabinet.IC-card writes renal function index (creatinine, urea nitrogen, total CO 2 and blood potassium) logical operation mode and corresponding batch renal function index (creatinine, urea nitrogen, total CO 2 and blood potassium) dry plate test board offset in advance.
Detect step:
5, start: instrument carries out self check, and carries out warming-up.
6, application of sample: get finger tip tip blood 35 μ l, in the loading slot of application of sample and renal function index (creatinine, urea nitrogen, total CO 2 and blood potassium) dry plate test board, be put in the dry sheet type fast detecting instrument check-out console turnover storehouse 11 with being about to check-out console, press "start" button, begin to detect.
7, detect: the illumination of the specific wavelength that reflective diode sends is mapped on the solid phase reaction carrier film of renal function index (creatinine, urea nitrogen, total CO 2 and blood potassium) dry plate test board, and back reflection is to photodiode, the change color on the continuous monitoring film.Photodiode is converted into electric signal with light signal, and through signals collecting/amplifying circuit signal is amplified.Little converter chip calculates renal function index (creatinine, urea nitrogen, total CO 2 and blood potassium) according to renal function index (creatinine, urea nitrogen, total CO 2 and blood potassium) logical operation mode, and the result is presented on the liquid crystal digital display.
8, print: press " printing " key on the casing, it is single to print test results report automatically.
The invention is not restricted to these disclosed embodiments, the present invention will cover the scope described in the patent book, and the various modification of claim scope and equivalence variation.
Claims (6)
1. dry sheet type fast detecting instrument, it is characterized in that light source (1) in the casing (13), light activated element (2), integrated light source driving circuit (4) and the surface-mounted integrated circuit (3) of signals collecting/amplifying circuit (5), little converter chip (6), temperature control device (7), IC-card card reader (8), mini-printer (9), communication device (10), check-out console pass in and out storehouse (11), variable-voltage power supply (14) and the display device (12) that is embedded on the casing (13) is formed by being fixed in; Wherein mini-printer (9) exit slot is positioned at the casing side surface, and IC-card card reader (8) and check-out console turnover storehouse (11) have corresponding draw-in groove respectively on casing, and light source (1) is fixed by rigidly fixing support with light activated element (2), becomes 15-45 degree angle; Light source driving circuit (4) and signals collecting/amplifying circuit (5) all are integrated on the surface-mounted integrated circuit (3), and are connected with light activated element (2) with light source (1) respectively; Being embedded in little converter chip (6) on the surface-mounted integrated circuit (3) connects and is controlling each functional circuit; Temperature control device (7), IC-card card reader (8), mini-printer (9), communication device (10), check-out console turnover storehouse (11) and display device (12) all link to each other with surface-mounted integrated circuit (3); Variable-voltage power supply (14) directly connects surface-mounted integrated circuit (3), temperature control device (7), IC-card card reader (8), mini-printer (9).
2. dry sheet type fast detecting instrument as claimed in claim 1 is characterized in that: wherein said light source (1) is ordinary monochromatic light source luminescent devices such as light emitting diode, laser diode.
3. dry sheet type fast detecting instrument as claimed in claim 1 is characterized in that: wherein said light source (1) is made up of a plurality of luminescent devices.
4. dry sheet type fast detecting instrument as claimed in claim 1 is characterized in that: wherein said light activated element (2) is light activated elements such as photoresistance or photodiode, in order to the induction reflected light, and light signal is converted into electric signal.
5. dry sheet type fast detecting instrument as claimed in claim 1 is characterized in that: wherein said temperature control device (7) comprises temperature-sensing element, heating plate, lagging casing; Be used for check-out console passed in and out that temperature in the storehouse is accurately constant to be controlled at 30～40 ℃.
6. dry sheet type fast detecting instrument as claimed in claim 1 is characterized in that: wherein said communication device (10) comprises data line, communication interface, is used to connect built-in miniature printer (9) or external outer computer and carries out data synchronization processing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101961867A CN101368942A (en) | 2008-09-17 | 2008-09-17 | Dry sheet type fast detecting instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101961867A CN101368942A (en) | 2008-09-17 | 2008-09-17 | Dry sheet type fast detecting instrument |
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| CN101368942A true CN101368942A (en) | 2009-02-18 |
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| CNA2008101961867A Pending CN101368942A (en) | 2008-09-17 | 2008-09-17 | Dry sheet type fast detecting instrument |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102384906A (en) * | 2011-08-01 | 2012-03-21 | 无锡蓝德生物医药有限责任公司 | Hemoglobin test board and preparation method and application thereof |
| CN104407127A (en) * | 2014-12-02 | 2015-03-11 | 深圳中科卉尔立生物科技有限公司 | Dry-type body fluid analyzer and analysis method thereof |
| WO2019024665A1 (en) * | 2017-08-02 | 2019-02-07 | 深圳市瀚海基因生物科技有限公司 | Circuit board for biological detection device and biological detection device |
| CN111458493A (en) * | 2019-01-22 | 2020-07-28 | 北京中生金域诊断技术股份有限公司 | Multifunctional biochemical analyzer |
-
2008
- 2008-09-17 CN CNA2008101961867A patent/CN101368942A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102384906A (en) * | 2011-08-01 | 2012-03-21 | 无锡蓝德生物医药有限责任公司 | Hemoglobin test board and preparation method and application thereof |
| CN102384906B (en) * | 2011-08-01 | 2016-01-20 | 无锡蓝德生物医药有限责任公司 | Hemoglobin detection plate and its preparation method and application |
| CN104407127A (en) * | 2014-12-02 | 2015-03-11 | 深圳中科卉尔立生物科技有限公司 | Dry-type body fluid analyzer and analysis method thereof |
| WO2019024665A1 (en) * | 2017-08-02 | 2019-02-07 | 深圳市瀚海基因生物科技有限公司 | Circuit board for biological detection device and biological detection device |
| CN111458493A (en) * | 2019-01-22 | 2020-07-28 | 北京中生金域诊断技术股份有限公司 | Multifunctional biochemical analyzer |
| CN111458493B (en) * | 2019-01-22 | 2024-04-12 | 北京中生金域诊断技术股份有限公司 | Multifunctional biochemical analyzer |
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Application publication date: 20090218 |