CN101361766A - Use of ilexlutifolia thumb total glycosides and preparation method thereof - Google Patents
Use of ilexlutifolia thumb total glycosides and preparation method thereof Download PDFInfo
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- CN101361766A CN101361766A CNA2007100755872A CN200710075587A CN101361766A CN 101361766 A CN101361766 A CN 101361766A CN A2007100755872 A CNA2007100755872 A CN A2007100755872A CN 200710075587 A CN200710075587 A CN 200710075587A CN 101361766 A CN101361766 A CN 101361766A
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Abstract
The invention relates to an application of broadleaf holly leaf glycosides and a preparation method thereof. Researches show that the broadleaf holly leaf glycosides can lower level of malondialdehyde (MDA) and triglyceride (TG) in liver tissues, increase level of reduced glutathione(GSH) of each dosage group in liver tissues, lower level of Alanine Aminotransferase (ALT) and Aspertate Aminotransferase (AST) in liver tissues; the broadleaf holly leaf glycosides has the activity of anti-alcoholic hepatitis and anti-adiposis hepatica. Compared with the prior art, the invention has the advantages of: 1. providing a new application of broadleaf holly leaf glycosides, in particular to an application on preparing medicines for curing adiposis hepatica and alcoholic hepatitis; 2. providing a preparation method for broadleaf holly leaf glycosides, and the preparation method is safe in production technics, economic in cost, high in efficacy, easy for quality control and more simple in preparation; and 3. providing a preparation of broadleaf holly leaf glycosides.
Description
[technical field]
The present invention relates to lectuce tea total glycosides, particularly its new application in pharmacy and preparation method thereof belongs to pharmaceutical field.
[background technology]
Folium Ilicis is Chinese distinctive resource species, up to now, as the history of folk tradition tea-drinking with existing more than 2000 year, is the large resource species of the peculiar class of China.As show listedly, the former plant of Folium Ilicis belongs to 5 sections 5 and belongs to 10 kinds of [Yunnan plant researchs 1992; 14 (3): 328 336].
The former plant of China's various places Folium Ilicis
| Chinese name | The Latin formal name used at school | Section's name | |
| 1 | Preface stalk Fructus Ligustri Lucidi | Ligustrum?pedunculare?Rehd. | Oleaceae |
| 2 | Purplestem privet leaf | L.purpurascens?Y.C.Yang | Oleaceae |
| 3 | Japan's Ligustrum groffiae Merr. | L.japonicum?Thunb?var.pubescens Koidz. | Oleaceae |
| 4 | Ligustrum robustum | L.robustum(Roxb.)B1. | Oleaceae |
| 5 | Ilex cornuta Lindl. | Ilex?cornuta?Lindl.ex?Paxt. | Aquifoliaceae |
| 6 | Ilex kudincha C. J. Tseng | I.kudincha?C.J.Tseng | Aquifoliaceae |
| 7 | Cortex Ilicis Rotundae | I.latifolia?Thunb. | Aquifoliaceae |
| 8 | Hair leaf cattle wood | Cratoxylum?prunifolium(Kurz)Dyer | Guttiferae |
| 9 | Ehretia cauminata R. Br Var. obovata (lindl.) johnst. | Ehretia?thyrsiflora(S.et?Z.)Nakai. | Ehretia cauminata R. Br Var. obovata (lindl.) johnst. section |
| 10 | Chinese photinia | Photinia?serruiata?Lindl. | Rosaceae |
So far Folium Ilicis has been carried out various pharmacological evaluation, found that Folium Ilicis has very high medical value: 1) to the effect of cardiovascular and cerebrovascular vessel; 2) suppress thrombosis, arteriosclerotic effect; 3) suppress platelet aggregation; 4) hypotensive activity; 5) inhibition of experimental thrombosis; 6) effect of blood fat reducing; 7) antioxidation; 8) hypoglycemic activity; 9) antiinflammatory action; 10) effect of raise immunity; 11) contraction of antagonism bronchial smooth muscle.
Show according to present data, do not retrieve the anti-fatty liver and the active report of alcoholic liver of relevant Folium Ilicis as yet.
The preparation method of lectuce tea total glycosides generally adopts macroreticular resin absorbing method.But oils and fats, lipotropic component or low polarity component in Folium Ilicis combine with macroporous resin, and resin surface will be coated with one deck oil layer; Moreover the solvent elution of macroporous resin is water or hydrophilic solvent, therefore when resin combines with oils and fats, will reduce the macroporous resin absorption carrying capacity greatly.When using the purification by macroporous resin total glycosides, generally can carry out the pretreatment grease removal for this reason.The grease removal link can be given and be brought problems in big the production: 1) organic solvent residual; 2) petroleum ether is a flammable liquid, can bring serious safety problem; 3) cause production cost to rise; 4) prolong the production time etc.; But, can have a strong impact on separating effect again as not grease removal.
[summary of the invention]
The objective of the invention is to propose new application, the particularly lectuce tea total glycosides application in preparation treatment fatty liver and alcoholic liver medicine of lectuce tea total glycosides.The applicant discovers that lectuce tea total glycosides can reduce hepatic tissue malonaldehyde (MDA), triglyceride (TG) content, increases each dosage group hepatic tissue reduced glutathion (GSH) content; Reduce hepatic tissue paddy third transaminase (ALT), millet straw transaminase (AST) content, anti-alcoholic liver that has and fatty liver activity.Lectuce tea total glycosides can former plant: preface stalk Fructus Ligustri Lucidi Ligustrum pedunculare Rehd., purplestem privet leaf L.purpurascens Y.C.Yang, Japan Ligustrum groffiae Merr. L.japonicum Thunb var.pubescens Koidz., Ligustrum robustum L.robustum (Roxb.) B1., Ilex cornuta Lindl. Ilex cornuta Lindl.ex Paxt., Ilex kudincha C. J. Tseng I.kudincha C .J.Tseng, Cortex Ilicis Rotundae I.latifolia Thunb., hair leaf cattle wood Cratoxylum prunifolium (Kurz) Dyer, Ehretia cauminata R. Br Var. obovata (lindl.) johnst. Ehretiathyrsiflora (S.et Z.) Nakai., among the Chinese photinia Photinia serrulata Lindl. one or more extract as raw material.
Another object of the present invention is to provide a kind of preparation method of lectuce tea total glycosides, comprise the steps:
A, get Folium Ilicis and pulverize, cross 20 mesh sieves, raw material;
B, add alcohol reflux 1-4 time that Folium Ilicis raw material weight 2-10 doubly measures 70-99%, merge extractive liquid, respectively;
C, with described extracting liquid filtering, being evaporated to relative density is 1.1～1.4, obtains ethanol extraction extractum;
D, the water of doubly measuring at described extractum adding 2-10 fully stir extraction, leave standstill, and get supernatant, carry out centrifugal filtration, get centrifugal liquid;
E, described centrifugal liquid is evaporated to relative density is 1.05～1.2;
F, described concentrated solution is carried out spray drying, exsiccant lectuce tea total glycosides powder.
Wherein, step B: ethanol weight is 3-8 times of described Broadleaf Holly Leaf, and concentration is 80%; The temperature of reflux, extract, is 60 ℃; Extraction time is 2 times, and extraction time is 1-5 hour for the first time, extraction time is 1-4 hour for the second time.
Step C: being concentrated into relative density is 1.1～1.2.
Step D: the weight of water is 3-8 times of described extractum, and extraction time is 1-4 time.
Step e: being concentrated into relative density is 1.05～1.10.
Step F: exsiccant inlet temperature is that 175 ± 5 ℃, leaving air temp are 85 ± 5 ℃.
In the preparation method of lectuce tea total glycosides, the present invention replaces with macroporous resin adsorption purification link of the prior art and adds water purification link.Because of lectuce tea total glycosides is a high polarity, hydrophilic composition adds in the extract extractum with water, and the glycoside material is easy to be gone out by water-soluble, and low polar water-insoluble fraction just forms precipitation or oil layer, thereby the aqueous solution part is separated with non-water-soluble part; The aqueous solution part can obtain the higher lectuce tea total glycosides powder of purity again through concentrate drying.Avoid organic solvent grease removal link like this, saved macroporous resin adsorption purification link, greatly reduced cost, shortened the time, improved power.Particularly in pharmacy procedure, this preparation method is safer, easy and be easy to quality control.
The present invention also provides a kind of ilexlutifolia thumb total glycosides formulation, and it is to be active component by containing lectuce tea total glycosides, adds that acceptable accessories or complementary composition are prepared from; Described preparation is meant capsule, tablet, pill, granule, injection, oral solutions.
The present invention is in terms of existing technologies: 1, proposed the new application of lectuce tea total glycosides, particularly the application when preparation treatment anti-fatty liver and alcoholic liver medicine; 2, proposed a kind of preparation method of lectuce tea total glycosides, its production technology safety, saving cost, effect height and more easy are easy to quality control; 3, propose a kind of ilexlutifolia thumb total glycosides formulation, specifically referred to capsule, tablet, pill, granule, injection, oral solutions.
[description of drawings]
Fig. 1 lectuce tea total glycosides production technology sketch
[specific embodiment]
Below in conjunction with testing the effect of lectuce tea total glycosides that illustrate to fatty liver and alcoholic liver.
With carbon tetrachloride and alcoholic liver is model, and the research lectuce tea total glycosides is to the effect of murine liver tissue malonaldehyde (MDA), reduced glutathion (GSH), triglyceride (TG), paddy third transaminase (ALT) and millet straw transaminase (AST).
Embodiment 1 lectuce tea total glycosides is to the influence of MDA, GSH, TG level in the alcohol-induced Kunming mouse alcoholic liver
Given the test agent: sample is a lectuce tea total glycosides.
Dosage: establishing 0.22,0.44, three dosage groups of 1.32g/kg BW, is 5,10,30 times that human body is recommended day dosing, and other establishes blank group, ethanol matched group.Dosage is respectively: 1) blank group 0.00g/kg BW; 2) ethanol matched group 0.00g/kg BW; 3) low dose group 0.22g/kg BW; 4) dosage group 0.44g/kg BW in; 5) high dose group 1.32g/kg BW.
Being tried thing prepares: make high dose group with pure water dilution 2.64g given the test agent to 40.0ml and tried thing every day, then with pure water dilute 5.0 respectively, the 10.0ml high dose group tried thing and makes low, middle dosage group to 30.0ml and tried thing.
Give the thing approach that tried: each dosage group is by once a day, and each 0.20ml/10g BW irritates stomach and tried thing, and blank group and ethanol matched group are irritated stomach by equal capacity and given pure water.
Experimental animal: white mice in the SPF level Kunming, female, in age in 6-8 week, body weight 18-22g is provided by Nanfang Medical Univ's Experimental Animal Center.
Test method: after experimental animal was quarantined three days, be divided into blank group, ethanol matched group and basic, normal, high three dosage groups at random, every group of 12 mices under laboratory condition.Three dosage groups are tried thing by various dose filling stomach respectively every day, and blank group and ethanol matched group are irritated stomach by equal capacity and given pure water.Animal is weighed weekly, to adjust given the test agent dosage, totally 30 days.Each dosage group and ethanol matched group are once irritated stomach with 0.12ml/10g BW dosage and are given 50% ethanol during off-test, the blank group is irritated stomach and is given the same dose pure water, each treated animal fasting was put to death after 16 hours, get hepatic tissue and make liver homogenate, measure malonaldehyde (MDA), reduced glutathion (GSH), triglyceride (TG), and get liver lobus sinister frozen section, and soudan III dyeing, light microscopic is observed pathological change down.
Conclusion: 1) given the test agent reduces each dosage group hepatic tissue MDA, TG content, the experimental result positive; 2) given the test agent increases each dosage group hepatic tissue GSH content, the experimental result positive; 3) be put to the test each dosage group hepatic cell fattydegeneration of product and ethanol matched group relatively alleviates, and the zoopery hepatic pathology is the positive as a result.
Experimental result shows that Folium Ilicis has the activity of anti-alcoholic liver.
Embodiment 2 lectuce tea total glycosides bring out the influence of ALT in the Kunming mouse fatty liver, AST level to carbon tetrachloride
Given the test agent: sample is a lectuce tea total glycosides.
Dosage: establishing 0.22,0.44, three dosage groups of 1.32g/kg BW, is 5,10,30 times that human body is recommended day dosing, and other establishes blank group, ethanol matched group.Dosage is respectively: 1) blank group 0.00g/kg BW; 2) ethanol matched group 0.00g/kg BW; 3) low dose group 0.22g/kg BW; 4) dosage group 0.44g/kg BW in; 5) high dose group 1.32g/kg BW.
Being tried thing prepares: make high dose group with pure water dilution 2.64g given the test agent to 40.0ml and tried thing every day, then with pure water dilute 5.0 respectively, the 10.0ml high dose group tried thing and makes low, middle dosage group to 30.0ml and tried thing.
Give the thing approach that tried: each dosage group is by once a day, and each 0.20ml/10g BW irritates stomach and tried thing, blank group and CCl
4Matched group is irritated stomach by equal capacity and is given pure water.
Experimental animal: white mice in the SPF level Kunming, female, in age in 6-8 week, body weight 18-22g is provided by Nanfang Medical Univ's Experimental Animal Center.
Test method: experimental animal is divided into blank group, CCl after quarantining three days at random under laboratory condition
4Matched group and basic, normal, high three dosage groups, every group of 11 mices.Three dosage groups are tried thing, blank group and CCl by various dose filling stomach respectively every day
4Matched group is irritated stomach by equal capacity and is given pure water.Animal is weighed weekly, to adjust given the test agent dosage, totally 30 days.Off-test is preceding with each treated animal fasting overnight 16 hours, each dosage group and CCl
4Matched group gives 0.125% CCl with 0.1ml/10g BW dosage lumbar injection
4, the injection of blank group gives the same dose Semen Maydis oil, is respectively tried agent amount group and continues to give given the test agent to testing end (with CCl
4Lumbar injection is at interval more than 4 hours).Pluck eyeball after 24 hours and get blood, separation of serum is measured paddy third transaminase (ALT), millet straw transaminase (AST), and gets liver and fix with 10% neutral formalin, the conventional pathological section of making, and HE dyeing, light microscopic is observed pathological change down.
Conclusion: 1) dosage group ALT, AST content and CCl
4Matched group is low weight, and difference has the highly significant meaning, and ALT and AST be the positive as a result; 2) dosage group pathology of livers and CCl
4Matched group is low weight, and difference has the highly significant meaning, and the zoopery hepatic pathology is the positive as a result.
Experimental result shows that Folium Ilicis has lipotropic activity.
Preparation method below in conjunction with the description of drawings lectuce tea total glycosides.
The preparation method of embodiment 3 lectuce tea total glycosides of the present invention comprises the steps:
A, will buy the Folium Ilicis that quality standard requires that meets that comes and weigh, pulverize, cross 20 mesh sieves, raw material;
B, respectively with 5 times of amount 80% edible ethanols reflux, extract, twice under 60 ℃ of conditions, extract for the first time 2 hours, extraction time is 1.5 hours for the second time, merges extracted twice liquid;
C, said extracted liquid is filtered, carry out concentrating under reduced pressure, the control thickening temperature is 60 ℃, concentrates pressure to be-0.085mPa, is concentrated into relative density and is 1.1～1.2 ethanol extraction extractum;
The concentrated extract of D, gained, the pure water that adds 5 times of amounts fully stirred 15 minutes, leave standstill 45 minutes after, inclining supernatant, so carries out twice, merges aqueous solution twice, and carries out centrifugal filtration, the centrifugal liquid that obtains is carried out next one and is concentrated.
E, the centrifugal liquid of above-mentioned gained is carried out concentrating under reduced pressure, 60 ℃ of temperature of control, to concentrate pressure be-0.085mPa that being concentrated into relative density is 1.05～1.10.
F, the concentrated solution of gained is carried out spray drying, the control inlet temperature is that 175 ± 5 ℃, leaving air temp are 85 ± 5 ℃.Get exsiccant lectuce tea total glycosides powder.
Wherein, extraction equipment is in the B step: multi-function extractor, volume are 4 cubic metres; Use haplo-effect concentrator in the C step; In the D step is tube centrifuge, rotary drum rotating speed: 16000r/min, and power: 3000W, flow speed control was at 300～400KG/ hour; Equipment in the F step is centrifugal spray drying tower,
Easy and be easy to quality control in the above-mentioned production technology, wherein: feed intake, extract, be concentrated in general production area and carry out; Extract, concentrate, avoided the pollution of artificial and environment by the channelization operation; Drying is carried out at 300,000 grades of dust proof workshops.
Preparation method below in conjunction with embodiment explanation ilexlutifolia thumb total glycosides formulation.
The preparation of embodiment 4 capsules
Take by weighing lectuce tea total glycosides 14～67g, edible cellulose 33～86g mixed 30 minutes with arbitrary proportion, up to mix homogeneously; Filled capsules, capsule are the 0# capsule, and filling specification is 0.44 gram/grain; Populated capsule is packed in the vial into 60 every bottle.
Wherein, mix in the G step and use EYH two dimensional motion mixer, the automatic capsule filling machine of the use in the H step (model: NJP-800) fill, carry out at 300,000 grades of dust proof workshops by filled capsules and capsule bottling.
Embodiment 5: tablet
Take by weighing 9～59 gram lectuce tea total glycosides, 30～80 gram microcrystalline Cellulose, 10～20 gram lactose, 1 gram magnesium stearate.Lectuce tea total glycosides, edible cellulose, lactose with the arbitrary proportion mix homogeneously, are made tablet by known tablet manufacturing technology and equipment.Product specification is: 0.5 gram/sheet, take each two every day three times.
Embodiment 6: pill
Lectuce tea total glycosides and microcrystalline Cellulose are crossed 100 mesh sieves respectively, and take by weighing Folium Ilicis 14～67 gram, microcrystalline Cellulose 33～86 grams, with the arbitrary proportion mix homogeneously, in the material that mixes, add a certain proportion of refining Mel, make pill by known pill manufacturing technology and equipment.Product specification is 0.25 gram/grain.
Embodiment 7: granule
Take by weighing lectuce tea total glycosides 14～67 grams respectively, microcrystalline Cellulose 33～86 grams.The part lectuce tea total glycosides dissolves with aqueous solution, and remaining lectuce tea total glycosides and microcrystalline Cellulose use drying process with atomizing to granulate with the arbitrary proportion mix homogeneously, and spray-drying process technology is consistent with the drying process with atomizing of the above-mentioned lectuce tea total glycosides of mentioning.
Embodiment 8: injection
Lectuce tea total glycosides 15～80 grams add the injection water and make 1000ml, are mixed with the solution that every ml contains 15～80mg, are filtered to clear and bright, potting, and high-temperature short-time sterilization promptly.
The solution preparation of injection, filtration, potting are all finished in the workshop more than 100,000 grades.
Embodiment 9: oral liquid formulations
Take by weighing lectuce tea total glycosides 5～15 gram, Mel 10 grams, be mixed with the solution of 100ml with purified water, filter, canned, high-temperature short-time sterilization promptly.
The present invention can summarize with other the concrete form without prejudice to spirit of the present invention or principal character.Therefore, no matter from which point, above-mentioned embodiment of the present invention all can only be thought can not limit the present invention to explanation of the present invention, claims have been pointed out scope of the present invention, and scope of the present invention is not pointed out in above-mentioned explanation, therefore, in implication suitable and any change in the scope, all should think to be included in the scope of claims with claims of the present invention.
Claims (9)
1. the application of lectuce tea total glycosides in preparation treatment fatty liver medicine.
2. the application of lectuce tea total glycosides in preparation treatment alcoholic liver medicine.
3. lectuce tea total glycosides according to claim 1 and 2 is characterized in that:
Extracting raw material is preface stalk Fructus Ligustri Lucidi Ligustrum pedunculare Rehd., purplestem privet leaf L.purpurascens Y.C.Yang, Japan Ligustrum groffiae Merr. L.japonicum Thunb var.pubescens Koidz., Ligustrum robustum L.robustum (Roxb.) Bl., Ilex cornuta Lindl. Ilex cornuta Lindl.ex Paxt., Ilex kudincha C. J. Tseng I.kudincha C.J.Tseng, Cortex Ilicis Rotundae I.latifolia Thunb., hair leaf cattle wood Cratoxylum prunifolium (Kurz) Dyer, Ehretia cauminata R. Br Var. obovata (lindl.) johnst. Ehretia thyrsiflora (S.et Z.) Nakai., at least a among the Chinese photinia Photinia serrulata Lindl..
4. the preparation method of lectuce tea total glycosides according to claim 1 and 2 is characterized in that:
A, get Folium Ilicis and pulverize, cross 20 mesh sieves, raw material;
B, add alcohol reflux 1-4 time that Folium Ilicis raw material weight 2-10 doubly measures 70-99%, merge extractive liquid, respectively;
C, with described extracting liquid filtering, being evaporated to relative density is 1.1～1.4, obtains ethanol extraction extractum;
D, the water of doubly measuring at described extractum adding 2-10 fully stir extraction, leave standstill, and get supernatant, carry out centrifugal filtration, get centrifugal liquid;
E, described centrifugal liquid is evaporated to relative density is 1.05～1.2;
F, described concentrated solution is carried out spray drying, exsiccant lectuce tea total glycosides powder.
5. the preparation method of lectuce tea total glycosides according to claim 4 is characterized in that:
Described step B: ethanol weight is 3-8 times of described Broadleaf Holly Leaf, and concentration is 80%; The temperature of reflux, extract, is 60 ℃; Extraction time is 2 times, and extraction time is 1-5 hour for the first time, extraction time is 1-4 hour for the second time.6, the preparation method of lectuce tea total glycosides according to claim 4 is characterized in that:
Described step C: being concentrated into relative density is 1.1～1.2.
7. the preparation method of lectuce tea total glycosides according to claim 4 is characterized in that:
Described step D: the weight of water is 3-8 times of described extractum, and extraction time is 1-4 time.
8. the preparation method of lectuce tea total glycosides according to claim 4 is characterized in that:
Described step e: being concentrated into relative density is 1.05～1.10.
9. the preparation method of lectuce tea total glycosides according to claim 4 is characterized in that:
Described step F: exsiccant inlet temperature is that 175 ± 5 ℃, leaving air temp are 85 ± 5 ℃.
10. ilexlutifolia thumb total glycosides formulation according to claim 1 and 2 is characterized in that:
Described preparation is: capsule, tablet, pill, granule, injection, oral solutions.
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| CNA2007100755872A CN101361766A (en) | 2007-08-10 | 2007-08-10 | Use of ilexlutifolia thumb total glycosides and preparation method thereof |
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| CNA2007100755872A CN101361766A (en) | 2007-08-10 | 2007-08-10 | Use of ilexlutifolia thumb total glycosides and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101966210A (en) * | 2010-08-09 | 2011-02-09 | 深圳市华熙生物科技有限公司 | Folium llicis latifoliae total glycoside and preparation method thereof |
| WO2012100612A1 (en) * | 2011-01-24 | 2012-08-02 | 北京大学 | Extraction method, total saponin and use of ilex kudingcha c.j.tseng leaves |
| CN102670672A (en) * | 2011-03-11 | 2012-09-19 | 中国医学科学院药用植物研究所 | Application of broadleaf holly leaf extract in preparation of medicine for reducing content of triglyceride in liver |
| CN102846720A (en) * | 2012-09-29 | 2013-01-02 | 广西梧州制药（集团）股份有限公司 | Composite for lowering blood fat and improving anoxia endurance |
| CN115067409A (en) * | 2022-05-25 | 2022-09-20 | 贵州泰和现代生态农业科技有限公司 | Application of lobular broadleaf holly leaf instant powder in preparation of lipid-lowering health-care food |
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2007
- 2007-08-10 CN CNA2007100755872A patent/CN101361766A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101966210A (en) * | 2010-08-09 | 2011-02-09 | 深圳市华熙生物科技有限公司 | Folium llicis latifoliae total glycoside and preparation method thereof |
| CN101966210B (en) * | 2010-08-09 | 2012-09-05 | 深圳市华熙生物科技有限公司 | Folium llicis latifoliae total glycoside and preparation method thereof |
| WO2012100612A1 (en) * | 2011-01-24 | 2012-08-02 | 北京大学 | Extraction method, total saponin and use of ilex kudingcha c.j.tseng leaves |
| JP2014504607A (en) * | 2011-01-24 | 2014-02-24 | 北京大学 | Extract method of bitter tea winter blue leaves, total saponin and use thereof |
| CN102670672A (en) * | 2011-03-11 | 2012-09-19 | 中国医学科学院药用植物研究所 | Application of broadleaf holly leaf extract in preparation of medicine for reducing content of triglyceride in liver |
| CN102846720A (en) * | 2012-09-29 | 2013-01-02 | 广西梧州制药（集团）股份有限公司 | Composite for lowering blood fat and improving anoxia endurance |
| CN102846720B (en) * | 2012-09-29 | 2013-11-13 | 广西梧州制药（集团）股份有限公司 | Composite for lowering blood fat and improving anoxia endurance |
| CN115067409A (en) * | 2022-05-25 | 2022-09-20 | 贵州泰和现代生态农业科技有限公司 | Application of lobular broadleaf holly leaf instant powder in preparation of lipid-lowering health-care food |
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