CN101358910B

CN101358910B - Multichannel syringe pump

Info

Publication number: CN101358910B
Application number: CN2008101517310A
Authority: CN
Inventors: 李朝阳; 王琸; 王珊; 崔立生
Original assignee: TIANDA TIANFA TECHNOLOGY Co Ltd
Current assignee: TIANDA TIANFA TECHNOLOGY Co Ltd
Priority date: 2008-09-24
Filing date: 2008-09-24
Publication date: 2011-03-30
Anticipated expiration: 2028-09-24
Also published as: CN101358910A

Abstract

The invention discloses a multi-channel injector pump for automatic sampling during drug dissolution rate testing. The structure comprises an upper plate and a lower plate fixed by a standing plate to form an integrated body, and the lower plate and the bottom plate are fixed by four supporting posts to form an integrated body. Ball-bearing screw rods are arranged in the corresponding holes of the upper plate and the lower plate. A moving plate is fixed by a screw nut and a backing post arranged in the middle of each ball-bearing screw rod. Two optical shafts are put through the moving plate, and both ends of either optical axis are fixed on the upper plate and the lower plate respectively. The ball-bearing screw rod is connected with a stepping motor by a shaft coupler. 8 injectors arranged in a front row and a rear row are fixed on the lower plate by an upper sleeve and a lower sleeve. An inching switch is arranged on the upper plate and the lower plate respectively, the contact of the inching switch and the upper and the lower locating bolts are arranged on the same axes, and higher safety is ensured besides the measurement accuracy of sampling. Because the inner cavity of the injector and the push rod head adopt polytetrafluoroethylene, corrosion resistance is ensured, and in addition, the inner cavity of the injector is free of liquid residue, therefore, cross contamination is avoided during drug test.

Description

Multichannel syringe pump

Technical field

The invention belongs to instrument, be specifically related to the multichannel syringe pump of taking a sample automatically when a kind of drug dissolution detects.

Technical background

Along with pharmaceuticals industry constantly develops, international and domestic all have strict vertification regulation to drug development and production.The suitable formulation of medicine stripping determination method is wider at present.Comprise tablet, capsule, granule, sustained release preparation, controlled release preparation, enteric coated preparations and the agent of transdermal card.The difference of drug dissolution experimental evidence formulation and difference, especially sustained release preparation and controlled release preparation dissolution test may reach several days, and sampling is often, now adopt the hand sampling complex operation, cycle is long, introduces personal error easily, makes the credibility that testing result is inaccurate and reduce measurement result.Adopt multichannel syringe pump can satisfy the needs of taking a sample automatically when drug dissolution detects, improve the testing efficient of medicine and the accuracy of testing result.

Summary of the invention

Automatically the required multichannel syringe pump of sampling when the purpose of this invention is to provide a kind of drug dissolution and detecting.

Followingly structural principle of the present invention is illustrated with reference to accompanying drawing.Multichannel syringe pump has: upper plate 1, lower plate 2, riser 3, pillar 4, base plate 5, ball screw 6, screw rod screw 7, pad post 8, movable plate 9, linear bearing 10, optical axis 11, stepper motor 12, pump support 13, shaft coupling 14, syringe 15, trap 16, on overlap 17, photoelectrical coupler 18, down microswitch 19, go up microswitch 20, lower limit screw 21, upper limit screw 22, anti-dazzling screen 23 etc.Concrete syndeton is: upper plate 1 is fixed as one by riser 3 with lower plate 2, and lower plate 2 is fixed as one by 4 pillars 4 with base plate 5, and framework forms a whole.Ball screw 6 is packed in upper plate 1 and the lower plate 2 corresponding holes, and screw rod screw 7, pad post 8 are equipped with in ball screw 6 middle parts, and screw is fixed movable plate 9 with the pad post.Two optical axises 11 pass two linear bearings 10 that are contained on the movable plate 9, and the optical axis two ends are individually fixed in upper plate 1 and lower plate 2.Ball screw 6 is connected by shaft coupling 14 with stepper motor 12.8 syringe 15 usefulness that two rows distribute before and after being trap 16 and last cover 17 fix with lower plate 2.Movable plate 9 top and bottom are equipped with lower limit screw 21 and upper limit screw 22 respectively.Anti-dazzling screen 23 is equipped with in the outside of movable plate 9, and photoelectrical coupler 18 is loaded on lower plate 2 and anti-dazzling screen 23 corresponding positions.Lower plate 2 is respectively equipped with down microswitch 19 and last microswitch 20 with upper plate 1, and the contact of following microswitch 19 and lower limit screw 21 are positioned at same axis, and the contact of last microswitch 20 and upper limit screw 22 are positioned at same axis.

Description of drawings

Fig. 1 is each parts connection diagram of the present invention.

Fig. 2 is the left view of Fig. 1.

Embodiment

Below the present invention is described further by specific embodiment.Each parts is assembled by accompanying drawing.Syringe adopts the precise injection device.The syringe outer tube material is a quartz glass, and the head of syringe intracavity bottom and injector push-rod adopts teflon, can play corrosion resistant effect for the medicine that has the pharmaceutical chemistry composition.Stepper motor 12 energising forward rotation drive ball screw 6 by shaft coupling 14 and rotate, and ball screw 6 rotates by screw rod screw 7 drive movable plates 9 and moves up along optical axis 11.Move the push rod that to drive 8 precise injection devices 15 on the movable plate 9 and move up, thus the syringe 15 inner negative pressure that produce.Because syringe 15 bottom openings directly contact with liquid, so liquid will be by the negative pressure inspiration of syringe inside.When stepper motor 12 energising backward rotation, drive ball screw 6 by shaft coupling 14 and rotate, ball screw 6 drives movable plate 9 by screw rod screw 7 and moves down along optical axis 11.The push rod that will drive 8 syringes that moves down of movable plate 9 moves down, and at this moment by the push rod of syringe 15 liquid of syringe inside is released from bottom opening.8 syringe 15 usefulness that two rows distribute before and after being trap 16 and last cover 17 fix with lower plate 2.Be push rod such as the piston in the syringe, piston moves and outer wall must be fixed, therefore need with trap 16 with syringe on cover 17 syringe is fixed in lower plate.

Its precision of the amount of liquid of syringe inspiration and discharge moves up or down distance by movable plate and guarantees, the distance that movable plate 9 moves is by step motor 12 control of spouting.For handling safety; the scope that movable plate 9 moves up and down is equipped with protective device, and promptly when stepper motor 12 control fails, movable plate 9 moves up and surpasses the predetermined upper limit; to touch by upper limit screw 22 and go up microswitch 20, and the whole pump housing will not be damaged thereby cut off the electricity supply.In like manner, the anti-dazzling screen 23 when movable plate 9 moves down on it is shading light electric coupler 18, and stepper motor 12 stalls have guaranteed the lower limit of injector push-rod.Movable plate 9 moves down above predetermined lower bound, will touch microswitch 19 down by lower limit screw 21, goes on foot motor 12 stalls of spouting thereby cut off the electricity supply to make.If the control of following microswitch 19 was lost efficacy again, the pad post 8 on the movable plate 9 will be run into lower plate 2, and stepper motor 12 generation idle running made movable plate 9 can not continue to move down, thereby guaranteed that 8 precise injection devices are not damaged this moment.

Characteristics of the present invention are, have higher security on the basis that guarantees the sampling accurate measurement, and the needs of automatic sampling in the time of can satisfying drug dissolution and detect have improved the accuracy of testing efficient and testing result. Because the head of syringe inner chamber and push rod adopts polytetrafluoroethylene (PTFE), can be corrosion-resistant, the cross pollution that brings when not having simultaneously residual liquid to avoid medicine to detect in the syringe inner chamber. Fixed quantity sampling employing multichannel syringe pump is optimal selection when detecting for medicine.

Claims

1. multichannel syringe pump, has upper plate (1), lower plate (2), riser (3), pillar (4), base plate (5), ball screw (6), screw rod screw (7), pad post (8), movable plate (9), linear bearing (10), optical axis (11), stepper motor (12), pump support (13), shaft coupling (14), syringe (15), trap (16), last cover (17), photoelectrical coupler (18), following microswitch (19), last microswitch (20), lower limit screw (21), upper limit screw (22), anti-dazzling screen (23), it is characterized in that upper plate (1) and lower plate (2) are fixed as one by riser (3), lower plate (2) is fixed as one by 4 pillars (4) with base plate (5), ball screw (6) is packed in upper plate (1) and the corresponding hole of lower plate (2), screw rod screw (7) is equipped with at ball screw (6) middle part, pad post (8), screw is fixing with movable plate (9) with the pad post, two optical axises (11) pass two linear bearings (10) that are contained on the movable plate (9), the optical axis two ends are individually fixed in upper plate (1) and lower plate (2), ball screw (6) is connected by shaft coupling (14) with stepper motor (12), 8 syringes (15) that two rows distribute before and after being are with trapping (16) and last cover (17) and lower plate (2) are fixed, movable plate (9) top and bottom are equipped with upper limit screw (22) and lower limit screw (21) respectively, anti-dazzling screen (23) is equipped with in the outside of movable plate (9), photoelectrical coupler (18) is loaded on lower plate (2) and the corresponding position of anti-dazzling screen (23), lower plate (2) is respectively equipped with down microswitch (19) and last microswitch (20) with upper plate (1), the contact of following microswitch (19) and lower limit screw (21) are positioned at same axis, and the contact of last microswitch (20) and upper limit screw (22) are positioned at same axis.