CN101356447B - 组织糖原的非侵入式mri测定 - Google Patents

组织糖原的非侵入式mri测定 Download PDF

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Publication number
CN101356447B
CN101356447B CN2006800347307A CN200680034730A CN101356447B CN 101356447 B CN101356447 B CN 101356447B CN 2006800347307 A CN2006800347307 A CN 2006800347307A CN 200680034730 A CN200680034730 A CN 200680034730A CN 101356447 B CN101356447 B CN 101356447B
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China
Prior art keywords
magnetic resonance
vivo
data
glycogen
proton
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English (en)
Chinese (zh)
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CN101356447A (zh
Inventor
彼得·C·M·范西尔
克雷格·K·琼斯
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Johns Hopkins University
Kennedy Krieger Institute Inc
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Johns Hopkins University
Kennedy Krieger Institute Inc
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/483—NMR imaging systems with selection of signals or spectra from particular regions of the volume, e.g. in vivo spectroscopy
    • G01R33/485—NMR imaging systems with selection of signals or spectra from particular regions of the volume, e.g. in vivo spectroscopy based on chemical shift information [CSI] or spectroscopic imaging, e.g. to acquire the spatial distributions of metabolites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance

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  • Physics & Mathematics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • General Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Health & Medical Sciences (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Optics & Photonics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
CN2006800347307A 2005-07-21 2006-07-21 组织糖原的非侵入式mri测定 Expired - Fee Related CN101356447B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US70139005P 2005-07-21 2005-07-21
US60/701,390 2005-07-21
PCT/US2006/028314 WO2007014004A2 (en) 2005-07-21 2006-07-21 Non-invasive mri measurement of tissue glycogen

Publications (2)

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CN101356447A CN101356447A (zh) 2009-01-28
CN101356447B true CN101356447B (zh) 2012-06-27

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US (1) US7683617B2 (enExample)
EP (1) EP1907873B1 (enExample)
JP (1) JP5123180B2 (enExample)
CN (1) CN101356447B (enExample)
WO (1) WO2007014004A2 (enExample)

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DE602005021969D1 (de) * 2004-07-29 2010-08-05 Otsuka Pharma Co Ltd Festproben-kern-magnetresonanzmessverfahren
EP2205986B1 (en) 2007-09-26 2013-07-03 The Johns Hopkins University Frequency referencing for chemical exchange saturation transfer (cest) mri
WO2009089274A2 (en) * 2008-01-07 2009-07-16 New York University Methods, system, and computer-accessible medium for assessment of glycosaminoglycan concentration in vivo by chemical exchange saturantion transfer
US8278925B2 (en) * 2008-03-26 2012-10-02 The General Hospital Corporation Method for relaxation-compensated fast multi-slice chemical exchange saturation transfer MRI
WO2010023132A1 (en) 2008-08-26 2010-03-04 Bracco Imaging S.P.A. Mri-cest diagnostic technique based on non-punctual analysis
WO2011091365A1 (en) * 2010-01-25 2011-07-28 Beth Israel Deaconess Medical Center Method for measuring magnetization transfer between molecules with magnetic resonance imaging
US8562529B2 (en) 2010-06-25 2013-10-22 John C. Hill Method and system for non-invasive determination of glycogen stores
WO2012082874A2 (en) 2010-12-14 2012-06-21 The Johns Hopkins University Use of non-labeled sugars and detection by mri for assessing tissue perfusion and metabolism
US9372245B2 (en) * 2011-11-21 2016-06-21 The Trustees Of The University Of Pennsylvania Endogenous magnetization contrast in MRI
WO2013082137A1 (en) * 2011-11-28 2013-06-06 New York University Apparatus, system, method and computer-readable medium for isolating chemical exchange saturation transfer contrast from magnetization transfer asymmetry under two-frequency rf irradiation
DE102013208475B4 (de) * 2013-05-08 2014-11-27 Siemens Aktiengesellschaft HF-Anregung mit zwei Resonanzfrequenzen zum Nachweis des CEST-Effekts mittels einer Magnetresonanzanlage
US9638781B2 (en) * 2014-02-03 2017-05-02 Toshiba Medical Systems Corporation Enhancement of MT effect and/or CEST effect
US10613180B2 (en) 2014-03-06 2020-04-07 The Johns Hopkins University Methods and systems of assessing tissue vascular permeability using non-labeled dextran
WO2015164452A1 (en) * 2014-04-23 2015-10-29 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Method and system for monitoring glucose transport and metabolism by spin-lock magnetic resonance
US9642593B2 (en) 2014-09-19 2017-05-09 MuscleSound, LLC System and method for non-invasive determination of human body fat
US10267881B2 (en) 2014-12-18 2019-04-23 The Johns Hopkins University Multi-echo parametric variation saturation (MePaVARS CEST imaging and other MR imaging
US10139460B2 (en) * 2015-02-23 2018-11-27 Synaptive Medical (Barbados) Inc. System and method for delta relaxation enhanced magnetic resonance imaging
US11013490B2 (en) 2016-11-15 2021-05-25 Musclesound, Inc. Non-invasive determination of muscle tissue size
US11064971B2 (en) 2016-11-30 2021-07-20 Musclesound, Inc. Non-Invasive determination of muscle tissue quality and intramuscular fat
US11096658B2 (en) 2017-02-02 2021-08-24 Musclesound, Inc. Non-invasive determination of pennation angle and/or fascicle length
US11160493B2 (en) 2017-03-03 2021-11-02 Musclesound, Inc. System and method for determining a subject's muscle fuel level, muscle fuel rating, and muscle energy status
JP6885207B2 (ja) * 2017-06-14 2021-06-09 愛知製鋼株式会社 マーカ検出方法及び車両用システム
US10775462B2 (en) * 2017-07-05 2020-09-15 The General Hospital Corporation System and method for direct saturation-corrected chemical exchange saturation transfer (DISC-CEST)
JP7621937B2 (ja) * 2018-09-14 2025-01-27 １０２５０９２９ カナダ インコーポレーテッド 代謝産物レベルのｉｎ－ｖｉｖｏ非侵襲的測定のための方法及びシステム
WO2021072730A1 (zh) * 2019-10-18 2021-04-22 深圳先进技术研究院 一种灌注成像方法及装置
WO2022115339A1 (en) * 2020-11-24 2022-06-02 The Johns Hopkins University Magnetic resonance imaging of glycogen and other polysaccharides by magnetic coupling with water

Citations (3)

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US5475308A (en) * 1992-11-13 1995-12-12 Sadis Bruker Spectrospin Societe Anonyme De Diffusion De L'instrumentation Scientifique Bruker Spectrospin Process for the excitation and acquistion of nuclear magnetic resonance signals, particularly in light water
US5639906A (en) * 1994-10-11 1997-06-17 The United States Of America As Represented By The Department Of Health And Human Services Fluorescent and NMR sensitive pH indicators
WO1998039664A1 (es) * 1997-03-06 1998-09-11 Universidad Nacional De Educacion A Distancia PROCEDIMIENTOS PARA LA OBTENCION DE IMAGENES Y ESPECTROS DEL pH EXTRACELULAR POR RESONANCIA MAGNETICA CON INDICADORES EXTRINSECOS CONTENIENDO 1H O 19F

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AU4656400A (en) * 1999-04-21 2000-11-17 Government of The United States of America, as represented by The Secretary Department of Health & Human Services, The National Institutes of Health, The Method for enhancing contrast produced by mri
ITMI20011706A1 (it) * 2001-08-03 2003-02-03 Bracco Imaging Spa Agenti di contrasto radiografici ionici e non ionici, utilizzabili per l'indagine diagnostica combinata tramite raggi-x e risonanza magnetic
AU2002364728A1 (en) 2001-12-13 2003-06-23 The Johns Hopkins University School Of Medicine Method for mr/nmr imaging
EP1466629A1 (en) * 2003-04-11 2004-10-13 BRACCO IMAGING S.p.A. Adducts between magnetic resonance shift reagents and substrates containing exchangeable protons for "CEST" applications
US7253620B1 (en) * 2004-03-08 2007-08-07 United States Of America, As Represented By The Secretary, Department Of Health And Human Services Spectrally selective suppression with steady-state free precession

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5475308A (en) * 1992-11-13 1995-12-12 Sadis Bruker Spectrospin Societe Anonyme De Diffusion De L'instrumentation Scientifique Bruker Spectrospin Process for the excitation and acquistion of nuclear magnetic resonance signals, particularly in light water
US5639906A (en) * 1994-10-11 1997-06-17 The United States Of America As Represented By The Department Of Health And Human Services Fluorescent and NMR sensitive pH indicators
WO1998039664A1 (es) * 1997-03-06 1998-09-11 Universidad Nacional De Educacion A Distancia PROCEDIMIENTOS PARA LA OBTENCION DE IMAGENES Y ESPECTROS DEL pH EXTRACELULAR POR RESONANCIA MAGNETICA CON INDICADORES EXTRINSECOS CONTENIENDO 1H O 19F

Also Published As

Publication number Publication date
US7683617B2 (en) 2010-03-23
EP1907873B1 (en) 2015-02-25
JP2009502244A (ja) 2009-01-29
WO2007014004A2 (en) 2007-02-01
JP5123180B2 (ja) 2013-01-16
CN101356447A (zh) 2009-01-28
US20080197840A1 (en) 2008-08-21
EP1907873A2 (en) 2008-04-09
WO2007014004A3 (en) 2008-04-10

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