CN101355920B - Alcohol-in-oil type emulsion comprising a multivalent metal salt - Google Patents
Alcohol-in-oil type emulsion comprising a multivalent metal salt Download PDFInfo
- Publication number
- CN101355920B CN101355920B CN200680049947.5A CN200680049947A CN101355920B CN 101355920 B CN101355920 B CN 101355920B CN 200680049947 A CN200680049947 A CN 200680049947A CN 101355920 B CN101355920 B CN 101355920B
- Authority
- CN
- China
- Prior art keywords
- type emulsion
- alcohol type
- weight
- oil bag
- oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Cosmetics (AREA)
Abstract
The present invention relates to emulsion science, especially within the area of alcohol-in-oil type emulsion, where the level of ions comprised in the alcohol-in-oil type emulsion is relatively high. In particular, the invention relates to a stable alcohol-in-oil type emulsion comprising a multivalent metal salt that may act as an antiperspirant.
Description
Technical field
The present invention relates to emulsion-type scientific domain, particularly, about stable oil bag alcohol type emulsion is provided, it comprises provides high-level electrolytical material.Conventionally, by adding multivalent metal salt can obtain high-caliber electrolyte in oil bag alcohol type emulsion.
Background technology
Perspire or diaphoresis are the completely naturally physiological process that animal bodies carries out, and it is many that many people perspire and recognize than them.Can be taken aback for most people, on average everyone produces the antiperspirant of 1/2～1 liter every day.
The mankind's antiperspirant self is tasteless to a great extent.The main cause of body odour is that microorganism is bred under hot, moist environment, and for example, in the mankind's oxter, oxter has highdensity sweat gland and relatively inaccessible, and it may cause owing to too much perspiring.On the surface of human body, axillary fossa is the hottest region always, and sweat gland provides dampness.Armpit hair has increased body odour, because improved surface area.
In most of culture, body odour is considered to disadvantageous, and therefore many people expect to eliminate or suppress body odour.A kind of apparent method that reduces abnormal smells from the patient is to remove some or all axil to send out.Reducing body odour and concentrating another kind of method or the extra method of perspiring is temporarily to stop up sweat duct, makes the antiperspirant that flow to skin surface be stopped or reduce.By using antiperspirant that this temporary transient obstruction can be provided.
Antiperspirant is to have the preparation of al-based compound as their " activity " compositions, and it can be the compound of any number in definite concentration and dosage form.By temporary transient obstruction (it stops antiperspirant to flow to skin surface) is provided in sweat duct, active component stops the ability of sweating for antiperspirant provides them.
Therefore, antiperspirant preparation can prevent body odour and reduce the antiperspirant being produced by health.
EP 0386018 has described a kind of effective Antipers pirant compositions, wherein slaine and the buffer salt combination being suspended in alcohol.But this compositions has the shortcoming that produces institute's particle sedimentation in storing process.This sedimentation has caused the spin (roller-ball) of the inhomogeneous administration of antiperspirant and slave unit to leak compositions.
In the production process of product, may be necessary that, by immiscible two kinds or more eurypalynous liquid mixing.In order to overcome this point, can in emulsion, these liquid be mixed, in this emulsion, oil or other hydrophobic materials temporarily or are enduringly dispersed in aqueous solution, or contrary, and this has formed O/w emulsion or water-in-oil emulsion.Conventionally these O/w emulsions or water-in-oil emulsion can provide stable solution.
Therefore, suggestion provides a kind of different system, for example, and oil bag alcohol type emulsion.This oil bag alcohol emulsion is not above-mentioned emulsion, because there is no water.But it is the mixture of immiscible two class I liquid Is, i.e. lower alcohol and oil.But the knowledge of having set up in this area is, contains high-caliber granule and be considered to unsettled as this class water-in-oil emulsion of polyvalent metal ion.
In order to improve the chemical stability that can discharge the particle of hydrochloric acid in the time there is water, need anhydrous composition, for example oil bag alcohol type emulsion.Meanwhile, even if described anhydrous emulsion is also stable under high-level electrolyte, so that being uniformly distributed of described particle to be provided.
Summary of the invention
For a kind of improved emulsion-type mixture is provided, avoid precipitation and the sedimentation of component and a kind of compositions is uniformly provided, wherein said emulsion-type mixture has the stability of raising at memory period, a first aspect of the present invention provides a kind of oil bag alcohol type emulsion, and it contains i) polyvalent metal ion; Ii) lower alcohol phase; And iii) oil phase.
In another aspect of this invention, provide a kind of method for the production of oil bag alcohol type emulsion.The method comprising the steps of:
(i) provide oil phase;
(ii) provide multivalent metal salt at alcohol the suspension in mutually;
(iii) the described oil phase providing in step (i) is mixed with the suspension providing in step (ii), to obtain mixture;
(iv) provide multivalent metal salt at alcohol the another kind of suspension in mutually; And
(v) by the described mixture obtaining in step (iii) and the multivalent metal salt providing in step (iv), at alcohol, the described another kind of suspension in mutually mixes, and wraps alcohol type emulsion to obtain oil.
In another aspect of this invention, provide a kind of antiperspirant.Described antiperspirant contains: (i) aluminum salt; (ii) lower alcohol phase; (iii) oil phase.
The detailed description of invention
The present inventor has been found that oil bag alcohol type emulsion of the present invention provides a kind of stable homogeneous latex emulsion type, even in the time that this emulsion-type contains high-level ion as polyvalent metal ion, wherein limit or avoided precipitation and the sedimentation of for example polyvalent metal ion.
In the present invention, term " precipitation " relates in mixture, for example, in oil bag alcohol type emulsion, form granule.If owing to reacting or forming insoluble matter by the cohesion of particle, can precipitate in solution.In most applications, by forming (" dropping out ") solids in solute phase or suspension, and this solids sinks to the bottom of oil bag alcohol type emulsion.
In the present invention, term " sedimentation " relates to particulate matter and is deposited as at liquid as the solid particle layer on bed base or the bottom of oil bag alcohol type emulsion.Sedimentation is by leaving standstill the caused deposition of suspension material.
oil bag alcohol emulsion
In a first aspect of the present invention, provide a kind of oil bag alcohol type emulsion.This emulsion type contains multivalent metal salt, lower alcohol phase and oil phase.In aspect this, described oil bag alcohol type emulsion has and enough maintains the viscosity that multivalent metal salt suspends equably at memory period.Oil bag alcohol type emulsion has anhydrous or substantially anhydrously knows advantage, and it obtains the good chemical stability of the multivalent metal salt suspending.It will be appreciated that, although high ion concentration, oil bag alcohol type emulsion of the present invention is stable.
prepare the method for oil bag alcohol emulsion
In another aspect of this invention, provide a kind of method for the production of oil bag alcohol type emulsion, wherein said method comprises step:
(i) provide oil phase;
(ii) provide multivalent metal salt at alcohol the suspension in mutually;
(iii) the described oil phase providing in step (i) is mixed with the described suspension providing in step (ii), to obtain mixture;
(iv) provide multivalent metal salt at alcohol the another kind of suspension in mutually; And
(v) by the described mixture obtaining in step (iii) and the polyvalent metal ion providing in step (iv), at alcohol, the described another kind of suspension in mutually mixes, and wraps alcohol type emulsion to obtain oil.
Although oil bag alcohol type emulsion is well known in the art, generally generally acknowledged high-caliber ion and stable oil bag alcohol type emulsion are incompatible.According to the present invention, for stable emulsion is provided, there are several behaviors should be noted that.According to the present invention, provide oil phase at first step in i).At second step ii) in provide polyvalent metal ion at alcohol the suspension in mutually.In order to obtain distributing better more uniformly of polyvalent metal ion, may be preferably, at the 3rd step iii oil phase being joined in suspension) in, by step I) in the described oil phase that provides join carefully in the suspension of the described polyvalent metal ion that step I provides in i), to obtain oil bag alcohol type emulsion.
In an embodiment of the invention, the normally aluminum salt of metallic compound comprising in the described polyvalent metal ion suspension that step I provides in i), for example, comprises the salt of active antiperspirant salts.But, in other embodiment, can use other multivalent metal salt that macroion level is provided, if this based composition will be benefited from being configured to stable oil bag alcohol type emulsion.In this class embodiment, step I ii) in the described mixture that obtains the given object of provided oil bag alcohol type emulsion can be provided, for example, be used as antiperspirant.In this case, step I is v) and v) selectable step, and can from the method, get rid of.
In yet another embodiment of the present invention, can be advantageously, oil phase is joined to the multivalent metal salt mixing mutually with alcohol by 2 times or more times, for example, in 3 times or more times, for example, in 4 times or more times, for example, in 5 times or more times.
Join step I ii by the described another kind of suspension that step I is provided in v)) in the described mixture that obtains to obtain oil bag alcohol type emulsion, can complete the step of this technique v).In addition, in order to obtain the better of multivalent metal salt and to distribute more uniformly, the described another kind of suspension that step I can be provided in v) gradually joins step I ii) in the described mixture that obtains.
In typical embodiment, step I i) and/or the multivalent metal salt existing in the described suspension that provides in v) of step I comprise bivalent metal ion or trivalent metal ion or quadrivalent metallic ion.
In one embodiment, the multivalent metal salt of step I in i) can be organic acid slaine.This class organic acid slaine has the function of buffer salt, and itself and strong acid example hydrochloric acid react, and it may be the product of active metal salt.By the mode of sort buffer salt, limit or even avoided because the caused negative effect of for example free hydrochloric acid is as skin irritation.
In one embodiment, the described multivalent metal salt that step I provides in i) can be organic acid slaine, for example aluctyl. or its hydrate.In this embodiment, organic acid slaine plays the effect of buffer salt.
In an embodiment of the invention, the multivalent metal salt comprising in the another kind of suspension of step I in v) can be the slaine of mineral acid.Conventionally, the multivalent metal salt of mineral acid has the function of active multivalent metal salt.In some embodiments, the active multivalent metal salt of this class can be to provide the multivalent metal salt of antiperspirant effect.By contacting with water, conventionally this class multivalent metal salt react with water or dampness generate strong acid for example hydrochloric acid as product.
In one embodiment, the multivalent metal salt of step I in i) can be the multivalent metal salt of mineral acid.The multivalent metal salt of this class mineral acid has the function of active multivalent metal salt.In some embodiments, the active multivalent metal salt of this class is to provide the multivalent metal salt of antiperspirant effect.By contacting with water, conventionally this class multivalent metal salt react with water or dampness generate strong acid for example hydrochloric acid as product.
In one embodiment, multivalent metal salt is aluminum chloride.
In an embodiment of the invention, the multivalent metal salt comprising in the described another kind of suspension of step I in v) is organic acid multivalent metal salt, itself and strong acid example hydrochloric acid react, and it can be the product of active multivalent metal salt and for example water.By the mode of sort buffer salt, limit or even avoided due to such as skin irritation of the caused negative effect of for example free hydrochloric acid.
In one embodiment, the multivalent metal salt that step I provides in i) can be aluctyl. or its hydrate.In this embodiment, organic acid multivalent metal salt plays the function of buffer salt.
Discharging in the time contacting with water in the embodiment of sour example hydrochloric acid due to multivalent metal salt, the feature of product of the present invention is in the time of pH value determination, to have low pH value.When measuring 50 % by weight oil bag alcohol type emulsion mixture, for example, in the time that step is mixed the pH value of obtained mixture with 50 % by weight water in v), pH value is in 0～5 scope, for example, in 0～4 scope, for example, in 0～3 scope, for example, in 1～5 scope, for example, in 2～3 scope.In the time measuring the pH of the oil bag alcohol type emulsion of 50 % by weight and the mixture of 50 % by weight water, the temperature of mixture must be 20 DEG C.
By contacting with water in the embodiment that discharges sour example hydrochloric acid, the feature of its product is because high-caliber ion has high conductivity.When the electrical conductivity of the 50 % by weight oil bag alcohol type emulsions that obtain in v) when measuring process and the mixture of 50 % by weight water, its electrical conductivity is in the scope of 4-18ms/cm, for example, in the scope of 5～16ms/cm, for example, in the scope of 6～15ms/cm, for example, in the scope of 7～14ms/cm, for example, in the scope of 8～13ms/cm, for example, in the scope of 9～12ms/cm, for example, in the scope of 10～11ms/cm.In the time measuring the electrical conductivity of mixture of 50 % by weight oil bag alcohol type emulsions and 50 % by weight water, the temperature of mixture must be 20 DEG C.
multivalent metal salt/buffer components
The multivalent metal salt comprising in the present invention can be any multivalent metal salt, and it provides the high-level electrolyte in oil bag alcohol type emulsion.Multivalent metal salt can be the salt of organic acid salt and/or mineral acid.
In one embodiment, described slaine comprises the combination of the multivalent metal salt of organic acid multivalent metal salt and mineral acid.
One preferred embodiment in, described multivalent metal salt is the combination of multivalent metal salt that has the multivalent metal salt of antiperspirant effect and have buffering effect.Conventionally, the multivalent metal salt with antiperspirant effect is inorganic salt, and the multivalent metal salt with buffering effect is organic acid multivalent metal salt.
In the prior art, known AlCl
3be effective antiperspirant salts, and most of commercial Antipers pirant compositions that can obtain contain AlCl
3as active component, for example, be dissolved in suitable solvent.AlCl
3form polymeric aluminum chloride antiperspirant active is provided by reacting with the water in antiperspirant, wherein polymeric aluminum chloride is as antiperspirant, and and then reduces the antiperspirant of discharging from sweat gland.But, use AlCl
3shortcoming be it and react to form polymeric aluminum chloride with the water in antiperspirant and also can produce hydrochloric acid as by-product, this may stimulate because peracidity causes local skin.In addition, with apply the cloth that region contacts also may be destroyed, the hydrochloric acid that these negative effects are all attributed on skin and in sweat duct forms.
Because the caused problem of peracidity of hydrochloric acid can be overcome, for example, by making the reactant salt of hydrochloric acid and weak acid, for example pK value is not less than 2.5 organic acid, and then according to known principle, the salt of strength hydrochloric acid discharges weak acid so that free weak acid and chloride to be provided.This class salt of weak acid is known as buffer salt.Can use the fact of the aluminate of weak acid to have advantages of and cause forming more volume polymeric aluminum chloride, and then cause higher antiperspirant effect.On the other hand, because existing free acid in skin environment is not exclusively hydrochloric acid now, but be not less than in pK value under 2.5 the impact of weak acid, acidity is significantly reduced, the aluminum salt formation of wherein said weak acid a part for the present composition.Because weak acid is less to the stimulation of skin, so final result is to have reduced or eliminated skin irritation.
In order to prevent raw too early the reacting of aluminum chloride and waterishlogging in antiperspirant, preferred described compositions is anhydrous.Especially, this is by using carrier system anhydrous or that do not have available water to obtain, becoming polymeric aluminum chloride and hydrochloric acid so that aluminum chloride can not experience hydrolysis.
Term " does not have available water " and " being substantially devoid of water " is that exchange is used mutually, it is in order to represent that in formula, existing water can not dissolved aluminum salt, because the amount of the water occurring very little, or because water other components in compositions are combined too strong.Therefore, for example, the ethanol 95% or AlCl in the sorbitol of liquid
3to can not experience hydrolysis.
Preferred compositions can be that weak acid has the pK value that is not less than 4, has especially the pK value that is not less than 4, is not less than particularly 3.5, is not less than especially 3.Use has the acid of these character will guarantee significantly to reduce skin irritant level.Preferably, described acid is acceptable on physiology.
Because many organic acid have various biological characteristicses, preferably the acid in the present composition has physiological effect such as astringent, antibacterial, antimicrobial, antiseptic, antifungal, antiparasitic, antiperspirant, deodorizer, antiinflammatory, emollient, anesthetis, hemorrhage, pruritus performance etc.The aluminum salt by use with one or more these performances, can expand the performance of the present composition, and expands its scope.Therefore,, if the acid using in the present composition has anti-fungal property, compositions of the present invention can be used for the treatment of or prophylactic treatment tinea pedis (being also known as tinea pedis).This disease right and wrong are usually shown in, and relevant with diaphoresis, and antiperspirant promotes to infect to the dipping of skin and makes it be difficult to treat.Even in the people who perspires in " normally ", desired, reduce the amount of perspire when fungus in treatment.
It is as follows that in aqueous solution, pK value is not less than 2.5 potential available acid: acetic acid, propanoic acid, citric acid, aspirin, benzoic acid, salicylic acid, ascorbic acid, nicotinic acid, tartaric acid, phthalic acid, lactic acid, fatty acid (oleic acid, linoleic acid, undecylenic acid, sad, Palmic acid, castor oil acid, stearic acid etc.), acyl group Cray Si Nike (acetylcretosinic), succinic acid, carbamoylphenoxyacetic acid, diacetyl salicylic acid, ortho-aminobenzoic acid, mefenamic acid, gentisic acid, tolfenamic acid, acetyl tartaric acid, agaric acid, formic acid, hydration acetic acid (subacetic), ellagic acid, fumaric acid, malic acid, the acid of slate cod croaker manini, oxalic acid, para-amino benzoic acid, gallic acid, cinnamic acid, arabo-ascorbic acid, sorbic acid, Aminocaproic Acid, aminomethyl phenyl formic acid, chlorine nitrogen dioctyl phthalate (tranxenamic acid), naturally occurring aminoacid is as glycine, alanine, valine, leucine, isoleucine, serine or threonine etc. and derivant thereof and tar acid, phenol, thymol and cation exchange resin.The meaning of term " its derivant " refers to that cited various acid also can further be replaced by various groups, wherein derivatively substituently exists for discussed acid one or more above-mentioned biological properties are provided.The substituent group that forms these derivants can be selected from wide region; such as phenyl, phenylamino, naphthyl, benzoyl, indenyl or various heterocyclic group be indyl, benzoxazolyl, pyridine radicals, benzindole base (benzindolyl) etc. such as, selectively these substituent groups itself also can be substituted base as halogen, alkyl, alkoxyl, can select amino being replaced by alkyl etc. replace.
Therefore, the multiple derivant of propanoic acid, acetic acid, phenylacetic acid, salicylic acid and ortho-aminobenzoic acid etc. can both suppress the synthetic of prostaglandin, therefore can play a role as local anti-inflammatory medicine.The example of propanoic derivatives is naproxen, ibuprofen, Benoxaprofen and bucloxic acid; The example of phenylacetic acid and acetogenin is indomethacin, bufexamac, diclofenac, sulindac and alclofenac (aclofenac); The example of salicyclic acid derivatives is aspirin, acetaminosalol, diflunisal, dipyrocetyl and fendosal; The example of ortho-aminobenzoic acid is flufenamic acid (etofenamic acid), flufenamic acid, meclofenamic acid and tolfenamic acid; The example of butanoic acid derivative is fenbufen.
In the above in cited acid, known some there is above-mentioned some biological property.Therefore, known salicylic acid, acetyl group tartaric acid, agaric acid, hydration acetic acid and ellagic acid have the performance of convergence, and known undecylenic acid, sad, propanoic acid, tolfenamic acid, arabo-ascorbic acid and sorbic acid have anti-fungal property.
It is acetylsalicylic acid, salicylic acid, benzoic acid, propanoic acid, sad, undecylenic acid, sorbic acid, ascorbic acid, lactic acid, malic acid, stearic acid, citric acid, phthalic acid, tartaric acid and naturally occurring aminoacid that pK value is not less than 2.5 sour preferred example.
In order to ensure to AlCl
3carry out gratifying neutralization with the whole hydrochloric acid that react produced of the water in antiperspirant, aluminum salt and the AlCl of acid
3between mole Billy preferably between 1: 1～1: 2, particularly about 2: 3.
In order to provide the compositions that is effective to hidroschesis object, the AlCl that preferably can exist in compositions of the present invention
33 grams of aluminum atom/kilogram of composition are up to, particularly 1.0～2.0 grams of aluminum atom/kilogram of composition with the amount of sour aluminum salt corresponding to total aluminum content.
Dissolve and/or dispersion AlCl
3with the carrier of the aluminum salt of weak acid can be any carrier that is generally used for joining Antipers pirant compositions.Therefore, carrier can be liquid, gel, semisolid or powder.Liquid-carrier can be alcohol, glycol, fat, fatty acid ester, fatty acid, paraffin, liquid polymers (as silicone oil), such as ethanol, isopropyl myristate, glycerol, propylene glycol etc. and composition thereof.Gel carrier can be that alcohol or other above-mentioned liquid-carriers for example contain cellulose derivative as the ethanol of hydroxy propyl cellulose.Semi-solid carrier can be polyglycols, paraffin (for example vaseline), fat or above-mentioned any liquid of containing polymer, for example, contain the poly liquid paraffin (its commodity are called Plastibase) of dissolving.Solid carrier can be Pulvis Talci, starch, Kaolin etc.
Compositions of the present invention can be prepared with preparing normally used method in the field of Antipers pirant compositions, and common described preparation comprises constituent is mixed simply.Therefore, fluid composition can be by dissolving aluminum chloride and weak acid or be dispersed in liquid-carrier; Selectively, aluminum chloride and weak acid can be dissolved respectively or is dispersed in two parts carrier or in two kinds of different carrier component, then this mixture be mixed.Can be by starting from fluid composition and adding gellant example cellulose derivative described above to obtain gel combination.
One preferred embodiment in, in oil bag alcohol type emulsion, comprise antiperspirant multivalent metal salt and/or buffer components.In this class oil bag alcohol type emulsion, the amount of the combination multivalent metal salt comprising accounts within the scope of 5 % by weight～50 % by weight of described oil bag alcohol type emulsion, for example, within the scope of 8 % by weight～40 % by weight, for example, in the scope of 10 % by weight～40 % by weight, for example, in the scope of 15 % by weight～35 % by weight.
Described multivalent metal salt can comprise metal ion.
Therefore, in some embodiments, the group that the metal ion comprising in oil bag alcohol type emulsion can select free aluminum (Al), ferrum (Fe), zirconium (Zr), calcium (Ca), copper (Cu), magnesium (Mg), titanium (Ti), plumbous (Pb), stannum (Sb) and hydrate thereof to form.
One preferred embodiment in, described oil bag alcohol type emulsion comprises aluminum salt.Preferably, this eka-aluminum salt is the aluminum salt with antiperspirant effect.
In this area, the known aluminum salt with antiperspirant effect comprises activated aluminum compound, and the choosing of described activated aluminum compound is following composition group freely: aluminum chloride, aluminium chlorohydrate, chlorination hydroxyl aluminum PEG coordination compound (chlorination hydroxyl aluminum Polyethylene Glycol coordination compound), chlorination hydroxyl aluminum PG coordination compound (chlorination hydroxyl aluminum propylene glycol coordination compound), aluminium chlorohydrate, dichloride hydroxyl aluminum, dichloride hydroxyl aluminum PEG coordination compound (dichloride hydroxyl aluminum Polyethylene Glycol coordination compound), dichloride hydroxyl aluminum PG coordination compound (dichloride hydroxyl aluminum propylene glycol coordination compound), sesquialter chlorination hydroxyl aluminum, sesquialter chlorination hydroxyl aluminum PEG coordination compound (sesquialter chlorination hydroxyl aluminum Polyethylene Glycol coordination compound), sesquialter chlorination hydroxyl aluminum PG coordination compound (sesquialter chlorination hydroxyl aluminum propylene glycol coordination compound), aluminum sulfate (aluminum sulfate buffer), eight chlorine hydroxyl aluminum zirconiums, eight chlorine hydroxyl aluminum zirconium GLY coordination compounies, pentachloro-hydroxyl aluminum zirconium, pentachloro-hydroxyl aluminum zirconium GLY coordination compound, aluminum zirconium tetrachlorohydrate, aluminum-zirconium tetrachlorohydrex GLY coordination compound, trichlorine hydroxyl aluminum zirconium, the antiperspirant medicament of trichlorine hydroxyl aluminum zirconium GLY coordination compound and combination thereof or any other FDA approval, or the combination of described medicament, the list meeting of wherein said medicine is often upgraded.
In one embodiment, described oil bag alcohol type emulsion contains the aluminum salt with buffering effect.One preferred embodiment in, described aluminum buffer agent can be aluctyl..
In a preferred embodiment of the present invention, oil bag alcohol type emulsion contains aluminum salt, and wherein said aluminum salt is the combination of activated aluminum salt and aluminum buffer agent, the combination of for example aluminum chloride and aluctyl..
In an embodiment of the invention, described multivalent metal salt can be to exist as hydrate.For example aluminum salt hydrate, particularly with the form of aluminum chloride hexahydrate.
In one embodiment, described aluminum salt can exist with the amount within the scope of 5 % by weight～50 % by weight, for example, within the scope of 10 % by weight～40 % by weight, for example, in the scope of 15 % by weight～35 % by weight, wherein the content of aluminum salt is the total amount with respect to oil bag alcohol type emulsion.
In yet another embodiment of the present invention, described oil bag alcohol type emulsion contains polyvalent metal ion, and wherein said multivalent metal salt comprises any combination of iron chloride or zirconium powder or its.
In other embodiments, described oil bag alcohol type emulsion contains the metal ion that selects the group that free aluminum (Al), ferrum (Fe), zirconium (Zr), calcium (Ca), copper (Cu), magnesium (Mg), titanium (Ti), plumbous (Pb), stannum (Sb) or its hydrate form.In these embodiments, described multivalent metal salt can have the effect that is different from antiperspirant effect.In some these embodiment, oil bag alcohol type emulsion can be used to for example antifungal coating of coating or the object for other.
One preferred embodiment in, the multivalent metal salt that described oil bag alcohol type emulsion contains mineral acid, can be particularly in aluminum chloride or its hydrate at multivalent metal salt.
lower alcohol
Described oil bag alcohol type emulsion contains the lower alcohol existing in discontinuous phase conventionally, and wherein oil phase exists with continuous phase conventionally.In a preferred embodiment, the alcohol existing mutually with discontinuous alcohol is the lower alcohol that contains 1～10 carbon atom, for example, contain the alcohol of 2～8 carbon atoms, for example, contain the alcohol of 2～6 carbon atoms, for example, contain the alcohol of 2～4 carbon atoms.
In the present invention, term " discontinuous phase " relates to alcohol phase, because alcohol phase partial suspended is in oil phase.Therefore, these parts of alcohol phase do not connect.
In the present invention, term " continuous phase " relates to oil phase, because this phase is to be centered around an alcohol phase coherent phase around substantially.
In one embodiment, alcohol comprises lower alcohol phase mutually, and the described lower alcohol that comprised here can be monohydric alcohol or dihydroxylic alcohols.
In one embodiment, alcohol comprises lower alcohol phase mutually, and the described lower alcohol that comprised here can be the alcohol with unbranched carbochain.
In one embodiment, alcohol comprises lower alcohol phase mutually, the group that the described lower alcohol that comprised here can select free ethanol, 1-propanol, 2-propanol, ethylene glycol, n-butyl alcohol, 2-butanols or its any combination to form.
In one embodiment, alcohol comprises such as lower alcohol of alcohol composition mutually, its amount make lower alcohol with respect to the total amount of oil bag alcohol type emulsion between 45 % by weight～95 % by weight, 55 % by weight～85 % by weight, for example 65 % by weight～75 % by weight.
oil phase
Preferably, oil bag alcohol type emulsion comprises continuous oil phase, and wherein said oil phase contains one or more oil and/or fat products, and it is selected from the hydrogenated oil and fat that obtains from plant origin or the similar products of its any derivant or any synthetic production.In an embodiment of the invention, oil phase comprises the hydrogenated oil and fat and its any derivant and any similarly synthetic two kinds or the combination of more kinds of products of producing product that are selected from plant origin, for example, be selected from hydrogenated oil and fat and its any derivant and any similarly synthetic three kinds or combination of more kinds of products of producing product of plant origin
And, can in oil phase, add one or more additives.Described additive can be selected from group that siloxanes, silane, wax, fatty acid ester, glyceride form and any derivant of this group.In an embodiment of the invention, oil phase comprises the hydrogenated oil and fat obtaining from plant origin derivant any with it or similarly synthetic two kinds or the combination of more kinds of components of producing product selection, for example three kinds or more kinds of component, for example four kinds or more kinds of component, for example five kinds or more kinds of component, for example six kinds or more kinds of component, for example seven kinds or more kinds of component.
In the preferred embodiment of the present invention, the hydrogenated oil and fat obtaining from plant origin can be castor oil hydrogenated or its any derivant or any similarly synthetic product of producing.
In one embodiment, oil bag alcohol type emulsion comprises oil phase, its amount make oil phase with respect to the content of the total amount of oil bag alcohol type emulsion in the scope of 0 % by weight～20 % by weight, for example, in the scope of 0.05 % by weight～20 % by weight, for example, in the scope of 0.1 % by weight～20 % by weight, for example, in the scope of 0.5 % by weight～20 % by weight, for example, in the scope of 1 % by weight～20 % by weight, for example, in the scope of 3 % by weight～15 % by weight, for example, in the scope of 5 % by weight～10 % by weight, for example, in the scope of 1 % by weight～5 % by weight, for example, in the scope of 1 % by weight～20 % by weight, for example, in the scope of 1 % by weight～15 % by weight, for example, in the scope of 2 % by weight～10 % by weight, for example 3 % by weight～5 % by weight.
product
The feature of product of the present invention is that oil bag alcohol type product emulsion has high emulsifying agent stability, and it provides the high homogeneity of multivalent metal salt in oil bag alcohol type emulsion.After the storage of product and storage, while detecting being separated of the type emulsion (phase separation), prove this high-caliber stability.
Therefore, oil bag alcohol type emulsion according to the present invention has being separated of maximum 10mm, for example maximum 5mm, for example maximum 3mm, for example maximum 1mm, for example maximum 0.7mm, for example maximum 0.5mm, for example maximum 0.4mm, for example maximum 0.3mm, for example maximum 0.2mm, for example maximum 0.1mm, wherein being separated is to store after one and a half months, and the result of the 0.5 liter of gauging bag alcohol type emulsion measurement comprising in the container that is 6.8mm to internal diameter.
Alternatively, in the time of longer time storage oil bag alcohol type emulsion, oil bag alcohol type emulsion has being separated of maximum 5mm, for example maximum 1mm, wherein this to be separated be after storage two weeks, for example, after 1 month, for example, after one and a half months, for example, after 2 months, for example, after 3 months, for example, after 4 months, for example, after 5 months, for example, after 6 months, the 0.5 liter of result that gauging bag alcohol type emulsion is measured for example, comprising after 12 months, and in the container that is 6.8mm to internal diameter.
During may there is this less important main cause being separated and be by day the evaporation of alcohol phase and during night the follow-up contraction of alcohol phase cause.Therefore,, if storage oil wraps alcohol type emulsion under the condition that there is no temperature and illumination effect or limited impact, can obtain the remarkable improvement being separated.
In the time mentioning " uniformly " oil bag alcohol type emulsion or " uniformly " mixture or mention " uniformly " in any other place of the present invention, it is to be understood as being distributed equably of comprising in compositions and/or granule is distributed by homogeneous in whole compositions.Here the term " uniformly " that used is also understood to that the granule suspending can not deposit, and the phase of emulsion can not separate substantially.
In an embodiment of the invention, oil bag alcohol type emulsion, antiperspirant or at step I ii of the present invention) or v) in the product that obtains can be substantially devoid of water.
In addition, the feature of oil bag alcohol type emulsion is that density is in the scope of 1.02g/ml～0.82g/ml, for example, in the scope of 0.87g/ml～0.97g/ml, for example, in the scope of 0.90g/ml～0.95g/ml.
Here the term " density " that used is appreciated that the weight (in grams) of every milliliter of detected oil bag alcohol type emulsion.This detection is carried out at 20 DEG C.
In one of the present invention preferred embodiment, when at 20 DEG C, measure 50 % by weight oil bag alcohol type emulsions (or antiperspirant or at step I ii) or v) in the product that obtains) during with the mixture of 50 % by weight water, oil bag alcohol type emulsion, antiperspirant or at step I ii) or v) in the product that obtains there is the pH value in 0～5 scope, for example, in 0～4 scope, for example, in 0～3 scope, for example, in 1～5 scope, for example, in 2～3 scope.
In other embodiment of the present invention, when at 20 DEG C, measure 50 % by weight oil bag alcohol type emulsions (or antiperspirant or at step I ii) or v) in the product that obtains) during with the mixture of 50 % by weight water, oil bag alcohol type emulsion, antiperspirant or at step I ii) or v) in the product that obtains there is the electrical conductivity within the scope of 4ms/cm～18ms/cm, for example, within the scope of 5ms/cm～16ms/cm, for example, in the scope of 6ms/cm～15ms/cm, for example, in the scope of 7ms/cm～14ms/cm, for example, in the scope of 8ms/cm～13ms/cm, for example, in the scope of 9ms/cm～12ms/cm, for example, in the scope of 10ms/cm～11ms/cm.
In one embodiment according to the present invention, provide a kind of oil bag alcohol type emulsion, it contains at least 3 kinds, for example at least 4 kinds, for example at least 5 kinds, for example at least 6 kinds, for example at least 7 kinds, for example freely component of following formed group of at least 8 kinds of choosings: alcohol is as ethanol; Organic acid salt is as aluctyl.; The salt of mineral acid is as aluminum chloride; Silicone derivative is as cyclopentasiloxane; Glyceride is as tristerin; Cetyl ester is as cetyl palmitate; Wax is as microwax; And oil is as castor oil hydrogenated.
If the ratio between alcohol phase and oil phase, in the scope clearly limiting, can obtain stable oil bag alcohol type emulsion.The alcohol of excessive level can cause the mutually transformation of oil bag alcohol type emulsion to alcohol oil-in emulsion.This is because the alcohol level improving in oil bag alcohol type emulsion can be released emulsifying agent outside the interface between alcohol phase and oil phase, causes forming flocculation, and oil bag alcohol type emulsion may be subsided.Therefore, oil bag alcohol type emulsion can contain alcohol, and it is measured in the scope of 45 % by weight～95 % by weight, for example, in the scope of 55 % by weight～85 % by weight, for example, in the scope of 65 % by weight～75 % by weight.
In one embodiment, oil bag alcohol type emulsion comprises multivalent metal salt as buffer salt; If described buffer salt exists with aluctyl., the amount of this aluctyl. within the scope of 4 % by weight～17 % by weight, for example 5 % by weight～16 % by weight, for example 6 % by weight～15 % by weight, for example 7 % by weight～14 % by weight, for example 8 % by weight～13 % by weight, for example 7 % by weight～12 % by weight.
In one embodiment, oil bag alcohol type emulsion contains activated aluminum compound; If described activated aluminum compound is aluminum salt, the amount of this aluminum salt within the scope of 4 % by weight～17 % by weight, for example 5 % by weight～16 % by weight, for example 6 % by weight～15 % by weight, for example 7 % by weight～14 % by weight, for example 8 % by weight～13 % by weight, for example 7 % by weight～12 % by weight.
Oil bag alcohol type emulsion can contain emollient.In one embodiment, described emollient comprises that silane derivative for example encircles penta silane, and it is measured in the scope of 1 % by weight～9 % by weight, for example 2 % by weight～8 % by weight, for example 3 % by weight～7 % by weight, for example 4 % by weight～6 % by weight.
Oil bag alcohol type emulsion can comprise emulsifying agent.In one embodiment, described emulsifying agent comprises such as tristerin of glyceride, and its amount is less than 5 % by weight, for example, be less than 4 % by weight, for example, be less than 3 % by weight, for example, be less than 2 % by weight, for example, be less than 1 % by weight.
Oil bag alcohol type emulsion can also contain other emollient.In one embodiment, described emollient contains cetyl ester, for example cetyl palmitate, and its amount is less than 5 % by weight, for example, be less than 4 % by weight, for example, be less than 3 % by weight, for example, be less than 2 % by weight, for example, be less than 1 % by weight.
Oil bag alcohol type emulsion can contain viscosity-control additive.In one embodiment, described viscosity-control additive contains wax as microwax, and its amount is less than 5 % by weight, for example, be less than 4 % by weight, for example, be less than 3 % by weight, for example, be less than 2 % by weight, for example, be less than 1 % by weight.
Oil bag alcohol type emulsion can also contain oil, and as castor oil hydrogenated, its amount is less than 5 % by weight, for example, be less than 4 % by weight, for example, be less than 3 % by weight, for example, be less than 2 % by weight, for example, be less than 1 % by weight.
Oil can be wrapped to alcohol type emulsion and be mixed with antiperspirant.One preferred embodiment in, this antiperspirant contains aluminum salt, lower alcohol phase and oil phase.
other embodiment
Oil bag alcohol type emulsion of the present invention is unique, although because contain high-caliber ion and/or electrolyte, this emulsion is still stable.Therefore, oil bag alcohol type emulsion of the present invention has practicality, as long as expect the stable emulsion that contains high-level ion.Therefore the oil bag alcohol type emulsion that, contains high-level ion can find application, for example antiperspirant, shampoo or health skin lotion in coating or cosmetic product.
Conventionally the description above is understandable, and oil bag alcohol type emulsion can be used as antiperspirant.
In one embodiment, oil bag alcohol type emulsion can be used as antiperspirant for reducing perspire.
Can be under people's arm, in hands, on foot or foot, obtain the reduction of this perspire.
As the result as antiperspirant, oil bag alcohol type emulsion can be for reducing less desirable body odour.
Especially, oil bag alcohol type emulsion can treat or alleviate the symptom of hyperhidrosis as antiperspirant.
In an embodiment of the invention, the oil bag alcohol type emulsion providing and/or the temperature of production process can not exceed 40 DEG C, because oil bag alcohol type emulsion may change alcohol oil-in emulsion into.
Embodiment
embodiment 1
The oil bag alcohol type emulsion that preparation contains activated aluminum salt and aluminum buffer salt.
| Amount, % by weight | ||
| 1 | Cyclopentasiloxane | 5～10 |
| 2 | Microwax | ＜1 |
| 3 | Cetyl palmitate | ＜1 |
| 4 | Tristerin | ＜1 |
| 5 | Castor oil hydrogenated | ＜1 |
| 6 | Aluctyl. | 8～20 |
| 7 | Alcohol (ethanol) | 30～40 |
| 8 | AlCl in alcohol (ethanol) 3, 18 (w/v) %/16.4 % by weight | 40～50 |
| Amount to | 100.00 |
By the excipient of weighing 1) be placed in container.At 23 DEG C, the short time stirs and within 40 seconds, adds excipient 2).At 27 DEG C, the short time stirs and within 40 seconds, adds excipient 3).At 28 DEG C, the short time stirs and within 30 seconds, adds excipient 4).Add excipient 5 stirring under 3 minutes 40 seconds), temperature is brought up to 39 DEG C simultaneously, in the time reaching the temperature of expectation, stop stirring.Mixture is kept to the short time, excipient 1)～5) mixture there is the continuity between cream and lotion.At 20 DEG C, by slaine 6) and solvent 7) mix 3 minutes, to obtain the suspension of slaine in solvent.At 22 DEG C, stir 3 minutes, carefully by excipient 1)～5) mixture join 6) and 7) suspension in, so that excipient 1 to be provided)～7) final mixture.At 23 DEG C, stir 3 minutes, carefully by alcohol 8) in slaine suspension join excipient 1)～7) mixture in.Stirring can and change according to used batch volumes, and the oil bag alcohol type that contains activated aluminum salt and aluminum buffer salt emulsion is provided.
embodiment 2
PH value and the electrical conductivity of the oil bag alcohol type Emulsion that contains activated aluminum salt and aluminum buffer salt provide the mixture of oily bag alcohol type Emulsion and water, and detect pH value and the electrical conductivity of gained mixture.
In following table, enumerate the result obtaining:
| The water adding | 40 % by weight | 50 % by weight | 80 % by weight |
| PH value | 2.20 | 2.37 | 2.96 |
| Electrical conductivity (ms/cm) | 8.74 | 10.52 | 11.63 |
embodiment 3
The stability of the present composition
To carrying out stability test with the oil bag alcohol type emulsion providing with embodiment 1 same way
By the oil bag alcohol type emulsion to provide with embodiment 1 same way at 25 DEG C with hatch in 25ml bottle.After one week, bottle is taken out from incubator, and assess stability.After analysis, bottle is put back to and in incubator, hatched 1 week (two weeks altogether) again.After two weeks, then from incubator, take out bottle, and in this assessment stability.Retest 4 times.
| Test No. | The test of 1 week at 25 DEG C of temperature | The test of 2 weeks at 25 DEG C of temperature |
| 1 | Liquid, is not separated uniformly | Liquid, is not separated uniformly |
| 2 | Liquid, is not separated uniformly | Liquid, is not separated uniformly |
| 3 | Liquid, is not separated uniformly | Liquid, is not separated uniformly |
| 4 | Liquid, is not separated uniformly | Liquid, is not separated uniformly |
Conclusion
The above results explanation, oil bag alcohol type dairy industry provided by the present invention is stable with uniformly, even if there is the multivalent salts of high-load (aluctyl. and AlCl
3) time, be not wherein still separated after 2 weeks in maintenance.
embodiment 4
At 30 DEG C, to the stability test accelerating with the oil bag alcohol type emulsion providing with embodiment 1 same way, after 24,48,72 and 96 hours, oil bag alcohol type emulsion is analyzed.
By the oil bag alcohol type emulsion to provide with embodiment 1 same way at 30 DEG C with hatch in 25ml bottle.After 24,48,72 and 96 hours, bottle is taken out to cool to room temperature and analysis from couveuse.
Aluctyl. and the AlCl of (0 hour) while determining hatching
3content and density.
| Time | Aluctyl. | AlCl 3 | Density |
| 0 hour | 10.34 % by weight | 10.27 % by weight | 0.9191 |
Its result is as following table:
| Analyze | 24 hours | 48 hours | 72 hours | 96 hours |
| Weight before hatching | 44.20g | 46.09g | 44.92g | 44.56g |
| Weight after hatching | 44.20g | 46.07g | 44.91g | 44.55g |
| Reach the weight after room temperature | 44.22g | 46.07g | 44.91g | 44.55g |
| Product profile | Uniform liquid | Uniform liquid | Uniform liquid | Liquid uniformly |
| Be separated | Without being separated | Without being separated | Without being separated | Without being separated |
| Precipitation | Without precipitation | Without precipitation | Without precipitation | Without precipitation |
| Color | White | White | White | White |
| AlCl 3(active component) % by weight | 10.35％ | 10.23％ | 10.25％ | 10.30％ |
| Aluctyl. % by weight | 10.55％ | 10.59％ | 10.73％ | 10.67％ |
| Density | 0.9204g/ml | 0.9172g/ml | 0.9176g/ml | 0.9183g/ml |
Conclusion
Before hatching, after hatching, (before cooling) and bottle reach the compliance check of weight after room temperature does not have the loss of product, and the fine difference of weight may be due to some variation in test mode process.
Accelerated test also demonstrates a kind of liquid phase of stable and uniform, and it is not separated, and precipitation, does not have stable density, and this has proved to have high-load multivalent salts (aluctyl. and AlCl
3) stable oil bag alcohol type emulsion.
Also prove in the time being included in oil bag alcohol type emulsion aluctyl. and AlCl
3do not experience any degraded or chemical reaction, because aluctyl. and AlCl
3amount keep constant.
embodiment 5
The stability of the present invention's oil bag alcohol type emulsion (called after product 2 in the back) and the described Antipers pirant compositions of embodiment (called after product 1 below) of EP0386018 can be compared.
At room temperature product 1 and 2 is placed in to the bottle of 500ml, and by day be exposed to night under light, have the small temperature of about 5 DEG C to reduce at night, without any rocking and moving.
| brooding time | product 1 | product 2 |
| time=0 | acutely rock-color: yellow and emulsus outward appearance.From the bottom of product 1 to end face be 11cm, be then the 5cm free space to bottle cap at product 1.On the inner surface of bottle, on product 1, there is little flocculation to be distributed between some larger flocculation. | acutely rock-color: the outer property of white and emulsus.From the bottom of product 2 to end face be 11cm, be then the 5cm free space to bottle cap at product 2.On the inner surface of bottle, on product 2, form " buttermilk shape " layer of product 2. |
| 10 minutes | the limpid structural change of product 1.Float a little not the larger flocculation in clear liquid assemble. | color: white and emulsus outward appearance.On the inner surface of bottle, on product 2, form " buttermilk shape " layer of product 2.Do not observe and be separated. |
| 2 hours 10 minutes | flocculation becomes more and more intensive, but still " fluey ", and start to move towards bottom.Flocculation has occupied about 2/3 liquid. | with identical after 10 minutes above. |
| 3 hours 10 minutes | flocculation still becomes more and more intensive, but still " fluey ", and start to assemble in bottom.Flocculation has occupied about 1/2 liquid. | with identical after 2 hours 10 minutes above.. |
| 1 day 2 hours 10 minutes | the precipitation that flocculation formed that in 11cm, approximately 2cm is moved to bottom occupies.The liquid at precipitation top keeps a little unlimpid, due to some little flocculation. | with identical after 3 hours 10 minutes above. |
| 2 days 2 hours 10 minutes | as above, but liquid on precipitation is limpider, and has some flocculation for precipitation. | with identical after 1 day 2 hours 10 minutes above. |
| 3 days 2 hours 10 minutes | precipitation as above, but liquid even limpider (may be able to understand thoroughly) on precipitation, and have some flocculation. | with identical after 2 days 2 hours 10 minutes above. |
| 6 days 2 hours 10 minutes | precipitation as above, but precipitation on liquid be almost limpid (it can be understood thoroughly), and only precipitation on have little flocculation. | with identical after 3 days 2 hours 10 minutes above. |
| 7 days 2 hours 10 minutes | with identical after 6 days 2 hours 10 minutes above. | with identical after 6 days 2 hours 10 minutes above. |
| 8 days 2 hours 10 minutes | with identical after 7 days 2 hours 10 minutes above. | with identical after 7 days 2 hours 10 minutes above. |
| 9 days 2 hours 10 minutes | with identical after 8 days 2 hours 10 minutes above.But only there is very little flocculation to remain on only on precipitation. | with identical after 8 days 2 hours 10 minutes above.But the clear liquid forming is brought up to about 2mm. |
| precipitation can be shaken into the profile of homogeneous, after 10 minutes, starts to form all the other flocculations by clear liquid did not surround a little. | product 2 (for example 2 days 2 hours 10 points in after) can easily be mixed, and it is by slight wobble, or the bottle once or 2 times of only reversing is with to form evenly very stable product. |
Conclusion
Product 1 has formed unsettled preparation, and it flocculates/precipitate and be separated into different phases only starting after 10 minutes to form.
In the whole Ninth Heaven of testing, product 2 has formed stable preparation.Only observe small 2mm be separated (started as 1mm at the 6th day, reached 2mm by the 9th day).This small being separated is that described concentrating is the small temperature contrast due to day and night, but the stability of product 2 is not affected because the concentrated of " carrier mass " alcohol forms.Can be by slight rocking, or only suppress once or twice and easily this small being separated by upset bottle, and again form all even stable products.
Claims (21)
1. an oil bag alcohol type emulsion, it contains:
I) AlCl
3, wherein AlCl
3the content that wraps alcohol type emulsion total amount with respect to described oil is within the scope of 7～12 % by weight;
Ii) ethanol, the content that wherein ethanol wraps alcohol type emulsion total amount with respect to described oil is within the scope of 55～85 % by weight;
Iii) oil phase, the cyclopentasiloxane that wherein said oil phase contains 5 % by weight～10 % by weight and the castor oil hydrogenated that is less than 1 % by weight,
Wherein, described oil bag alcohol type emulsion further comprise 8-20 % by weight aluctyl., be less than 1 % by weight microwax, be less than the cetyl palmitate of 1 % by weight and be less than the tristerin of 1 % by weight.
2. oil bag alcohol type emulsion according to claim 1, wherein, aluminum salt is aluminum salt hydrate.
3. oil bag alcohol type emulsion according to claim 1, wherein, described oil bag alcohol type emulsion has being separated of maximum 10mm, and wherein said being separated is after storage one and a half months, the 0.5 liter of result that oil bag alcohol type emulsion is measured comprising in the container that is 6.8mm to internal diameter.
4. oil bag alcohol type emulsion according to claim 1, wherein, described oil bag alcohol type emulsion has being separated of maximum 5mm, and wherein said being separated is after storage two weeks, the 0.5 liter of result that oil bag alcohol type emulsion is measured comprising in the container that is 6.8mm to internal diameter.
5. oil bag alcohol type emulsion according to claim 1, wherein, described oil bag alcohol type emulsion has the density within the scope of 0.82g/ml～1.02g/ml.
6. oil bag alcohol type emulsion according to claim 1, wherein, in the time that measure 50 % by weight at 20 DEG C described in, oil wraps the mixture of alcohol type emulsion and 50 % by weight water, described oil bag alcohol type emulsion has the pH value in 0～5 scope.
7. according to aforementioned oil bag alcohol type emulsion claimed in claim 1, wherein, in the time that measure 50 % by weight at 20 DEG C described in, oil wraps the mixture of alcohol type emulsion and 50 % by weight water, described oil bag alcohol type emulsion has the electrical conductivity within the scope of 4mS/cm～18mS/cm.
8. according to oil bag alcohol type emulsion in any one of the preceding claims wherein, wherein, described oil bag alcohol type emulsion is used in coating or cosmetic product.
9. according to the oil bag alcohol type emulsion described in any one in aforementioned claim 1-7, wherein, described oil bag alcohol type emulsion is used to antiperspirant, shampoo or health skin cream.
10. oil bag alcohol type emulsion according to claim 8, wherein, described oil bag alcohol type emulsion is used to antiperspirant, shampoo or health skin cream.
11. 1 kinds of methods for the production of oil bag alcohol type emulsion claimed in claim 1, described method comprises step:
(i) provide oil phase, the cyclopentasiloxane that wherein said oil phase contains 5 % by weight～10 % by weight and be less than the castor oil hydrogenated of 1 % by weight, further add be less than 1 % by weight microwax, be less than the cetyl palmitate of 1 % by weight and be less than the tristerin of 1 % by weight;
(ii) provide the suspension of aluctyl. in ethanol;
(iii) the described oil phase providing in step (i) is mixed with the described suspension providing in step (ii), to obtain mixture;
(iv) provide AlCl
3another kind of suspension in ethanol; And
(v) by the AlCl providing in the described mixture obtaining in step (iii) and step (iv)
3described another kind of suspension in ethanol mixes, to obtain described oil bag alcohol type emulsion, wherein aluminum salt is 7～12 % by weight with respect to the content of described oil bag alcohol type emulsion total amount, and ethanol is 55～85 % by weight with respect to the content of described oil bag alcohol type emulsion total amount.
12. methods according to claim 11, wherein, step I ii) be by by step I) in the described oil phase that the provides described suspension that gradually joins step I and provide in i) carry out.
13. methods according to claim 11, wherein, step is v) that described another kind of suspension by step I is provided in v) gradually joins step I ii) in the described mixture that obtains carry out to obtain described oil bag alcohol type emulsion.
14. methods according to claim 11, wherein, in the time of the mixture of oil bag alcohol type emulsion measure 50 % by weight at 20 DEG C described in and 50 % by weight water, in the scope of the pH value when mixture that wraps alcohol type emulsions at the 50 % by weight oil that step is obtained in v) is measured 0～5.
15. methods according to claim 11, wherein, in the time of the mixture of oil bag alcohol type emulsion measure 50 % by weight at 20 DEG C described in and 50 % by weight water, the electrical conductivity when mixture that wraps alcohol type emulsions at the 50 % by weight oil that step is obtained in v) is measured is within the scope of 4ms/cm～18ms/cm.
16. 1 kinds of antiperspirant that comprise oil bag alcohol type emulsion claimed in claim 1.
Oil bag alcohol type emulsion in 17. claim 1～8 described in any one is for the application of antiperspirant.
The application of antiperspirant described in oil bag alcohol type emulsion or claim 16 in 18. claim 1～8 described in any one in the medicine for the preparation of reduction perspire.
Application described in 19. claim 18, wherein, under people's arm, in hands or obtain the reduction of described perspire on people's foot or foot.
The application of antiperspirant described in oil bag alcohol type emulsion or claim 16 in 20. claim 1～8 described in any one in the medicine for the preparation of the undesired abnormal smells from the patient of minimizing.
The application of antiperspirant described in oil bag alcohol type emulsion or claim 16 in 21. claim 1～8 described in any one in the medicine of the symptom for the preparation for the treatment of or alleviation hyperhidrosis.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75431305P | 2005-12-29 | 2005-12-29 | |
| US60/754,313 | 2005-12-29 | ||
| DKPA200501849 | 2005-12-29 | ||
| DKPA200501849 | 2005-12-29 | ||
| PCT/DK2006/050085 WO2007073740A1 (en) | 2005-12-29 | 2006-12-27 | Alcohol-in-oil type emulsion comprising a multivalent metal salt |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101355920A CN101355920A (en) | 2009-01-28 |
| CN101355920B true CN101355920B (en) | 2014-10-01 |
Family
ID=36587271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200680049947.5A Expired - Fee Related CN101355920B (en) | 2005-12-29 | 2006-12-27 | Alcohol-in-oil type emulsion comprising a multivalent metal salt |
Country Status (4)
| Country | Link |
|---|---|
| CN (1) | CN101355920B (en) |
| BR (1) | BRPI0620810B1 (en) |
| MY (1) | MY148926A (en) |
| NZ (1) | NZ569550A (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2925834A1 (en) * | 2013-10-09 | 2015-04-16 | Riemann Trading Aps | Improved antiperspirant composition |
| CN104606372A (en) * | 2014-12-30 | 2015-05-13 | 唯美度科技（北京）有限公司 | Tea polyphenol polyol-in-oil preparation and preparation method thereof |
| DE102016204685A1 (en) * | 2016-03-22 | 2017-09-28 | Beiersdorf Ag | Antiperspirant stick in the form of an O / W emulsion |
| CN110477493B (en) * | 2019-09-29 | 2021-07-20 | 东华大学 | Long-acting deodorization jacket and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5143718A (en) * | 1987-09-15 | 1992-09-01 | Riemann Trading Aps | Antiperspirant composition |
| US5198416A (en) * | 1988-09-30 | 1993-03-30 | Shell Oil Company | Alcohol-in-oil drilling fluid system comprising polycyclic polyetherpolyol |
| US6139851A (en) * | 1997-03-24 | 2000-10-31 | Shiseido Company, Ltd. | Hair cosmetics |
| CN1299270A (en) * | 1998-05-01 | 2001-06-13 | 宝洁公司 | Antiperspirant compositions contg. 1,2-hexanediol |
| CN1506039A (en) * | 2002-12-13 | 2004-06-23 | Cosmetic method and composition for enhancing attraction |
-
2006
- 2006-12-27 MY MYPI20082339A patent/MY148926A/en unknown
- 2006-12-27 BR BRPI0620810A patent/BRPI0620810B1/en not_active IP Right Cessation
- 2006-12-27 CN CN200680049947.5A patent/CN101355920B/en not_active Expired - Fee Related
- 2006-12-27 NZ NZ569550A patent/NZ569550A/en not_active IP Right Cessation
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5143718A (en) * | 1987-09-15 | 1992-09-01 | Riemann Trading Aps | Antiperspirant composition |
| US5198416A (en) * | 1988-09-30 | 1993-03-30 | Shell Oil Company | Alcohol-in-oil drilling fluid system comprising polycyclic polyetherpolyol |
| US6139851A (en) * | 1997-03-24 | 2000-10-31 | Shiseido Company, Ltd. | Hair cosmetics |
| CN1299270A (en) * | 1998-05-01 | 2001-06-13 | 宝洁公司 | Antiperspirant compositions contg. 1,2-hexanediol |
| CN1506039A (en) * | 2002-12-13 | 2004-06-23 | Cosmetic method and composition for enhancing attraction |
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0620810A2 (en) | 2011-11-22 |
| MY148926A (en) | 2013-06-14 |
| CN101355920A (en) | 2009-01-28 |
| BRPI0620810B1 (en) | 2018-09-18 |
| NZ569550A (en) | 2010-11-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US9827177B2 (en) | Antiperspirant products with protein and antiperspirant salts | |
| JP6549670B2 (en) | Use of isosorbide caprylate / caprate in anti-odor and antiperspirant agents | |
| RU2615131C2 (en) | Zinc-lysine complex | |
| RU2621130C2 (en) | Zinc amino acid/trimethyl halide | |
| RU2638791C2 (en) | Composition with halide precursors of amino acid / zinc trimethylglycine | |
| ES2442252T3 (en) | Antiperspirant compositions | |
| CN101355920B (en) | Alcohol-in-oil type emulsion comprising a multivalent metal salt | |
| CN103167868B (en) | Hydrogel particle being coated with lipid and preparation method thereof | |
| JPS6130567A (en) | Method of stabilizing urea | |
| JP5512974B2 (en) | Alcohol-in-oil emulsion containing polyvalent metal salt | |
| BR112018015257B1 (en) | COMPOSITION FOR ALPHA-GEL FORMATION, ALPHA-GEL COMPOSITION AND EXTERNAL SKIN PREPARATION COMPOSITION | |
| JP5138299B2 (en) | Dermal preparation | |
| JP2010285411A (en) | Humectant, and hair cosmetic, skin cosmetic and bathing agent containing the same | |
| JP4277239B2 (en) | Antibacterial composition | |
| JP6130646B2 (en) | O / W emulsion | |
| BR112018003209B1 (en) | COMPOSITION INCLUDING A LACTAM AND AN ALKYL OR ALKENYL LACTATE | |
| JPH0967231A (en) | Antimicrobial agent composition containing fatty acid silver salt and cosmetic containing the fatty acid silver salt | |
| JPS6039716B2 (en) | Cationic surfactant composition | |
| JP2005008580A (en) | Composition containing ceramides |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20141001 Termination date: 20181227 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |