CN101347464A - Health products capable of reducing blood sugar and method of preparing the same - Google Patents
Health products capable of reducing blood sugar and method of preparing the same Download PDFInfo
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Abstract
The invention provides a health care product for decreasing blood sugar and a preparation method thereof. The product produces genetic characteristics variation of monascus strains in the space environment and cultivates the bacteria with stable genetic characteristics by sifting on the earth. The bacteria stores in the ordinary microorganism center of China Committee for Culture Collection of Microorganisms and the serial number is CGMCC No.2614. The bacteria is manufactured to red yeast rice through seed culture, solid fermentation, baking and grinding and then the red yeast rice is mixed with propolis, chromium picolinate, pearl shell powder and western ginseng powder for preparation. The health care product prepared by the invention can effectively decrease blood sugar with small toxicity and side effect and has obvious effect on prevention and adjuvant therapy of diabetes.
Description
Technical field
The present invention relates to a kind of biological product and preparation method thereof, be meant a kind of health product that can blood sugar lowering and preparation method thereof especially.
Background technology
Diabetes are one of modal chronic diseases.Along with the raising of people's living standard, the increase of aged tendency of population and fat incidence rate, the sickness rate of diabetes is ascendant trend year by year.Diabetes are outstanding feature clinically with the hyperglycemia, and common sympton has polydipsia, polyuria, polyphagia and becomes thin etc.Diabetes can cause the infringement of health multisystem if can not get effective treatment.Up to the present, diabetes are a kind of can not radical cures, but the disease that can well control.And studies show that diabetes can be prevented and treat, and the dietetic therapy rule is a kind of preferable prevention and therapeutic scheme.At present, common health food has the dietary fiber class and contains microelement kind, as China Patent No. be 200410030746.3,200410012279.1 and application number be disclosed health-care product for curing diabetes in the inventions such as 200510033148.6; And the Chinese medicine ingredients class, as China Patent No. be 200510043221.8 and application number be disclosed health-care product for curing diabetes in the inventions such as 200510033583.9.
The important Chinese medicine that Monas cuspurpureus Went has both as a kind of tradition food, treatment is widely applied to food and pharmaceutical field.Because of its bacterial strain can produce the statin substance that is used for the treatment of cardiovascular and cerebrovascular disease, and studied widely.In recent years, Monas cuspurpureus Went also is applied in the middle of the medicine of treatment diabetes, a kind of natural drug composition that is used to prepare Remedies for diabetes that has been 200510134207.9 disclosure of the Invention as the patent No., (1-10: 10-1) compatibility forms said composition, comes blood sugar regulation and blood fat with the synergism of Ganoderma and Monas cuspurpureus Went according to a certain percentage by Ganoderma and Monas cuspurpureus Went; Application number a kind of medicine for the treatment of diabetes that has been 200710179322.7 disclosure of the Invention, raw material is Fructus Momordicae charantiae slice, Radix Sophorae Flavescentis, the Rhizoma Anemarrhenae, Semen Ziziphi Spinosae, Rhizoma Zingiberis Preparatum, Monas cuspurpureus Went, Pericarpium Citri Reticulatae, Radix Et Rhizoma Rhei and Semen Persicae, and this medicine is treated with the heat clearing away the turbid descending can be by the obvious abnormal carbohydrate metabolism that improves the type ii diabetes rat model of insulin resistant and islet cell function.Yet the natural lovastatin class content of material that produces in the common monascus is lower, and takes medicine for a long time human body is still had certain toxic and side effects.
Just at present for the present situation of diabetes mellitus prevention and treatment, blood sugar lowering is complication prevention and little health product and the still further research and development of medicine of toxic and side effects simultaneously.
Summary of the invention
In view of this, main purpose of the present invention is to provide a kind of blood sugar lowering, health product that toxic and side effects is little and preparation method thereof, and the health product that make by the inventive method are prevent diabetes effectively, and treatment of diabetes is played assosting effect.
The invention provides a kind of preparation method of health product that can blood sugar lowering, comprise the steps:
Will be in China Committee for Culture Collection of Microorganisms's common micro-organisms center preservation, the strain that is numbered CGMCC No.2614 is as producing strain, behind seed culture, solid fermentation, oven dry and crushing screening, make Hongqu powder (red colouring agent), add propolis, chromium picolinate again, to make preparation after each component mixing, each set of dispense ratio is:
Hongqu powder (red colouring agent) 18.5-55.5 part, propolis 8.4-25.2 part, chromium picolinate 0.015-0.045 part.
Wherein, the strain of described CGMCC No.2614 is spaceship-carried purplish red aspergillosis kind, makes it that inherited character variation take place under the spatial environments of space, returns ground after the stable strain of inherited character is cultivated in screening.
Wherein, the condition of described spaceship-carried purplish red aspergillosis kind is controlled to be the three-axis stabilization attitude for the breeding attitude of satellite, track is oval inclined plane, the satellite transit perigee altitude is 180km, altitude of the apogee is on the track of 460km, track tilts 63 °, carried 15 days, during the average daily dose of space radiation dosage be 0.401-0.169mGy.
Preferable, the preparation process of described Hongqu powder (red colouring agent) comprises:
The streak inoculation of spaceship-carried purplish red aspergillosis kind on the inclined-plane seed culture medium, was cultivated 8-20 days under 20-35 ℃ of temperature;
Be inoculated into afterwards in the liquid seed culture medium, shaking table was cultivated 4-10 days under 20-37 ℃ of temperature;
Be inoculated into then in the solid fermentation culture medium, under 20-35 ℃ of temperature, cultivated 12-24 days;
With the back 60 ℃ of oven dry down of the purplish red bent sterilization that ferments, then pulverize, cross the 80-100 mesh sieve.
Preferable, the preparation method of described health product that can blood sugar lowering also comprises having added Concha Margaritifera powder 16.3-48.9 part, Radix Panacis Quinquefolii powder 5.2-15.6 part.
Wherein, the preparation method of described health product that can blood sugar lowering also comprises having added adjuvant sodium carboxymethyl cellulose 0.54-0.66 part and magnesium stearate 0.9-1.1 part.
The present invention also provides a kind of health product according to method for preparing, and described health product comprise: Hongqu powder (red colouring agent) 18.5-55.5 part, propolis 8.4-25.2 part, chromium picolinate 0.015-0.045 part.
Preferable, the health product according to method for preparing also comprise: Concha Margaritifera powder 16.3-48.9 part, Radix Panacis Quinquefolii powder 5.2-15.6 part.
Optionally, described health product are capsule, tablet or granule.
The preparation method of health product that can blood sugar lowering provided by the invention is to be main component with Monas cuspurpureus Went, propolis and chromium picolinate, is aided with Concha Margaritifera and Radix Panacis Quinquefolii, mixes by preferred proportion.Wherein, preparation method provided by the invention is utilized the comprehensive function of factors such as the microgravity, irradiation space, fine vacuum of spatial environments, bacterial strain is morphed, filter out constantly in the incubation on ground again that useful variation is many, luffing is big, stability is strong, high-yield early-maturing, purplish red aspergillosis strain that character is good, the lovastatin amount that this bacterial strain produces can reach 1.5 times of common Monas cuspurpureus Went.
Propolis has the effect of prevention and treatment diabetes, can physical strength reinforcing, and enhancing immunity can resist that the wound that causes because of diabetes is difficult to heal and the ulcer symptom; Wherein contained flavonoid, terpene compound have the synthetic liver raw sugar of the external source of promotion glucose, and islet cells is shielded; Materials such as contained catalpol, pterostibene have tangible blood sugar lowering effect; Trace element such as chromium, calcium, magnesium, potassium have the activation insulin in the propolis, improve carbohydrate tolerance, participate in effects such as pancreas cells adjusting.
Chromium picolinate can directly act on histiocyte by cell membrane smoothly, can strengthen insulin active, improves the human body carbohydrate metabolism.
Concha Margaritifera, it forms through calcine for the shell that several produce the fresh water bivalves of Margarita, chemical constituent is mainly calcium carbonate, has tonifying YIN, suppressing the hyperactive liver and subsiding YANG, arresting convulsion hemostatic effect, can be used for treating diseases such as demented infantile convulsion, the vertigo, tinnitus cardiopalmus, hematemesis and epistaxis, metrorrhagia.
Radix Panacis Quinquefolii has the function of boosting qi and nourishing yin, pathogenic fire purging relieving restlessness, nourishing the stomach to promote the production of body fluid, should be used for the treatment of diseases such as hypertension, dizzy, pharyngalgia xerostomia.
By preparation method provided by the invention with above-mentioned these compositions by the combined health product that make of suitable proportion, can blood sugar lowering, and toxic and side effects is little, have positive effect aspect the prevention of diabetes and the auxiliary treatment.
Description of drawings
Fig. 1 is the process chart of the inventive method.
The specific embodiment
Below in conjunction with specific embodiment the present invention is further set forth.
Shown the technological process of the specific embodiment of the invention among Fig. 1.The preparation method of a kind of health product that can blood sugar lowering provided by the invention comprises the steps:
(1) preparation of Hongqu powder (red colouring agent):
A. prepare strain: spaceship-carried growth period is suitable, the purplish red song that growth conditions is good (Monascus purpureus) strain, the breeding attitude of satellite is controlled to be the three-axis stabilization attitude, the I quadrant directed towards ground of satellite wherein, satellite recovery capsule microcephaly is a heading, track is oval inclined plane, the satellite transit perigee altitude is 180km, altitude of the apogee is on the track of 460km, track tilts 63 °, the position, perigee near 35 ° of north latitude, satellite flight 15 days, fly altogether 236 the circle, 236 circles are by the center, recovery area, space radiation dosage is 5.893mGy to the maximum during this time, and minimum is 2.484mGy, and average daily dose is between the 0.401-0.169mGy, the maximum temperature of satellite seed point for measuring temperature during track is 20.72 ℃ (TH2 points), and minimum temperature is 7.21 ℃ (TH34 points); The inherited character variation takes place in this strain under the special space environment of space, return ground after the stable strain of inherited character is cultivated in screening, this strain (is positioned at the Datun Road, Chaoyang District, Beijing City on July 31st, 2008 at China Committee for Culture Collection of Microorganisms common micro-organisms center, Institute of Microorganism, Academia Sinica) preservation is numbered CGMCC No.2614;
Experimental result shows that the spaceship-carried purplish red aspergillosis kind after steric requirements mutation is stable on inherited character, and stronger production adaptability is arranged, fermentation period shortens, and detects through institute of microbiology of the Chinese Academy of Sciences, and qualification result is: spaceship-carried purplish red aspergillosis kind is cultivated on wort agar, the initial stage bacterium colony forms limitation, and smooth, the mycelium quality is tight, the velvet shape, neat in edge, the bright pink color of Punica granatum L., the substrate mycelium maroon, aging back bacterium colony is orange, radial wrinkle is arranged, back side brown purple; In the initial stage of that bacterium colony is more smooth on the MEA culture medium, mycelium velvet shape, back side darkorange, the high about 1.5-2mm of aging back aerial hyphae; On the CYA culture medium, the colony growth limitation, smooth, rule is owed at the edge, and mycelia is white in color, and is thin; In above culture medium, all there are not secretions and pigment to generate.Observe the irregular branch of mycelium under the micro-condition, have every, be multi-cellular structure, include a large amount of apricot oil droplets, the about 4-6.5 μ of diameter m, the many Dan Sheng of conidium, the bunchiness growth is also arranged, resemble a pear in shape 12-18 * 9-14 μ m, aging quilt device is orange red, subsphaeroidal, diameter 28-40 μ m, the thicker about 2-2.5 μ m of wall, ascospore in the most quilt device forms bad, is empty nest, includes orange red pigment; The ascospore ellipse, smooth, faint yellow, 6-7 * 4.5-5.2 μ m;
B. spawn culture, fermentation: the streak inoculation of spaceship-carried purplish red aspergillosis kind on the inclined-plane seed culture medium, was cultivated 8-20 days under 20-35 ℃ of temperature; Be inoculated into afterwards in the liquid seed culture medium, shaking table was cultivated 4-10 days under 20-37 ℃ of temperature; Be inoculated into then in the solid fermentation culture medium, under 20-35 ℃ of temperature, cultivated 12-24 days;
C. baking is bent: the Monas cuspurpureus Went that ferments is sterilized back 60 ℃ dry down;
D. crushing screening: the Monas cuspurpureus Went of oven dry is pulverized, crossed the 80-100 mesh sieve.
(3) proportioning is mixed: the Hongqu powder (red colouring agent) for preparing and propolis, chromium picolinate, Concha Margaritifera powder, the Radix Panacis Quinquefolii powder of making powder, cross the 80-100 mesh sieve respectively are mixed in proportion, stir.
(4) make preparation: add sodium carboxymethyl cellulose and magnesium stearate mixing in the compositions of preparation in step (3), make preparation, packing detects, and preserves.
In addition, the goods of the inventive method preparation also can be used for preparing can blood sugar lowering medicine.
Embodiment 1:
The Hongqu powder (red colouring agent) 35.8g of spaceship-carried purplish red aspergillosis strain fermenting and producing
Propolis 16.8g
Chromium picolinate 0.02g
Concha Margaritifera powder 34.8g
Radix Panacis Quinquefolii powder 10.63g
Sodium carboxymethyl cellulose 0.65g
Magnesium stearate 1.3g
Each component is made tablet according to above-mentioned preparation method, every 0.65g.
Embodiment 2:
The Hongqu powder (red colouring agent) 35.5g of spaceship-carried purplish red aspergillosis strain fermenting and producing
Propolis 17g
Chromium picolinate 0.02g
Concha Margaritifera powder 35g
Radix Panacis Quinquefolii powder 10.38g
Sodium carboxymethyl cellulose 0.6g
Magnesium stearate 1.5g
Each component is made tablet according to above-mentioned preparation method, every 0.65g.
Embodiment 3:
The Hongqu powder (red colouring agent) 36g of spaceship-carried purplish red aspergillosis strain fermenting and producing
Propolis 16.3g
Chromium picolinate 0.02g
Concha Margaritifera powder 34.8g
Radix Panacis Quinquefolii powder 10.86g
Sodium carboxymethyl cellulose 0.62g
Magnesium stearate 1.4g
Each component is made tablet according to above-mentioned preparation method, every 0.65g.
Obtain the toxicological test research of preparation according to the method described above
(1) acute toxicity test: horn method is tested Wistar kind rat (body weight 180-200g) and Kunming mouse (body weight 18-20g) respectively, goods per os of the present invention is irritated stomach to be given, stopped eating 16 hours before irritating stomach, dosage is greater than 10g/kgBW, observe a week continuously, animal activity is normal, does not find any symptom, true border innocuous substance.
(2) micronucleus test: goods per os of the present invention is irritated stomach be applied to Kunming mouse (body weight 24-28g), irritate the stomach amount by 100 of crowd's recommended amounts 0.065g/kgBW, establish 3 dosage groups for 50 and 10 times, be 6.5g/kg, 3.25g/kg and 0.65g/kg, other establishes positive controls and negative control group, continuous administration 2 days, 6 hours execution mices after the last administration, get the bone marrow of sternum film-making, dyeing, microscopy, record contains micronucleus PCE number, calculate micronuclear rates, each dosage group is compared with negative control group, all finds no significant difference, positive controls is compared the difference that highly significant is arranged with negative control group, the result shows that goods of the present invention do not bring out micronuclear rates and increase.
(3) spermatic aberration test: goods per os of the present invention is irritated stomach be applied to the male level of Kunming kind mice (body weight 24-28g), irritate the stomach amount by 100 of crowd's recommended amounts 0.065g/kgBW, establish 3 dosage groups for 50 and 10 times, be 6.5g/kg, 3.25g/kg and 0.65g/kg, other establishes positive controls and negative control group, continuous administration 5 days, put to death in the 35th day after using for the first time, get both sides epididymis film-making, dyeing, microscopy, record distortion sperm count, calculate aberration rate, detecting each dosage group through sum of ranks compares with negative control group, all find no significant difference, positive controls is compared the difference that highly significant is arranged with negative control group, the result shows that goods of the present invention do not produce mutagenesis to sexual cell.
(4) Salmonella reversion test: use frame shift type mutant TA97a, TA98, with base substitution type mutant TA100, four bacterial strains of TA102, five inherited characters of bacterial strain all reach required standard after measured, adopt the flat board pre-method of temperature in advance, laboratory sample dosage is chosen to be 5mg/ ware, 2.5mg/ ware, 1.0mg/ ware, 0.5mg/ ware, five dosage of 0.1mg/ ware, positive control 2-AF (10 μ g/ ware), MMS (2 μ l/ ware), Fluorenone (0.2 μ g/ ware), 2-AA (12 μ g/ ware), experimental result is that goods of the present invention do not have tangible inducing action to four kinds of mutants.
Fed experiment in (5) 30 days: select the Wistar kind for use, 40 of the ablactation rats of body weight 70-90g, be divided into 4 groups at random, one group of negative matched group (powdery normal feedstuff), three groups is experimental group in addition, give goods of the present invention respectively with 100 of crowd's recommended amounts (0.065g/kgBW), 50,10 times, be 6.5g/kgBW, 3.25g/kgBW, 0.65g/kgBW, mix feedstuff, freely take in, observe the active situation of a. animal every day, hair color, ingest and drainage situation etc. b. growth promoter and food utilization, c. hematological indices, d. biochemical indicator, e. organ coefficient, f. pathologic finding, experimental result shows that each treated animal is movable normal at experimental session, the hair color glossiness is better, ingests and drains normally, finds no symptom and occurs.
The above only is preferred embodiment of the present invention, and is in order to restriction the present invention, within the spirit and principles in the present invention not all, any modification of being done, is equal to replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (9)
- One kind can blood sugar lowering the preparation method of health product, it is characterized in that, comprise the steps:Will be in China Committee for Culture Collection of Microorganisms's common micro-organisms center preservation, the strain that is numbered CGMCC No.2614 is as producing strain, behind seed culture, solid fermentation, oven dry and crushing screening, make Hongqu powder (red colouring agent), add propolis, chromium picolinate again, to make preparation after each component mixing, each set of dispense ratio is:Hongqu powder (red colouring agent) 18.5-55.5 part, propolis 8.4-25.2 part, chromium picolinate 0.015-0.045 part.
- 2. the preparation method of health product that can blood sugar lowering according to claim 1, it is characterized in that, the strain of described CGMCC No.2614 is spaceship-carried purplish red aspergillosis kind, make it that inherited character variation take place under the spatial environments of space, return ground after the stable strain of inherited character is cultivated in screening.
- 3. the preparation method of health product that can blood sugar lowering according to claim 2, it is characterized in that, the condition of described spaceship-carried purplish red aspergillosis kind is controlled to be the three-axis stabilization attitude for the breeding attitude of satellite, track is oval inclined plane, the satellite transit perigee altitude is 180km, and altitude of the apogee is on the track of 460km, and track tilts 63 °, carried 15 days, during the average daily dose of space radiation dosage be 0.401-0.169mGy.
- 4. the preparation method of health product that can blood sugar lowering according to claim 1 is characterized in that the preparation process of described Hongqu powder (red colouring agent) comprises:The streak inoculation of spaceship-carried purplish red aspergillosis kind on the inclined-plane seed culture medium, was cultivated 8-20 days under 20-35 ℃ of temperature;Be inoculated into afterwards in the liquid seed culture medium, shaking table was cultivated 4-10 days under 20-37 ℃ of temperature;Be inoculated into then in the solid fermentation culture medium, under 20-35 ℃ of temperature, cultivated 12-24 days;With the back 60 ℃ of oven dry down of the purplish red bent sterilization that ferments, then pulverize, cross the 80-100 mesh sieve.
- 5. the preparation method of health product that can blood sugar lowering according to claim 1 is characterized in that described health product also add Concha Margaritifera powder 16.3-48.9 part, Radix Panacis Quinquefolii powder 5.2-15.6 part.
- 6. the preparation method of health product that can blood sugar lowering according to claim 1 is characterized in that described health product also add adjuvant sodium carboxymethyl cellulose 0.54-0.66 part and magnesium stearate 0.9-1.1 part.
- 7. the health product of a method preparation according to claim 1 is characterized in that described health product comprise: Hongqu powder (red colouring agent) 18.5-55.5 part, propolis 8.4-25.2 part, chromium picolinate 0.015-0.045 part.
- 8. health product according to claim 7 is characterized in that, described health product comprise: Concha Margaritifera powder 16.3-48.9 part, Radix Panacis Quinquefolii powder 5.2-15.6 part.
- 9. according to claim 7 or 8 described health product, it is characterized in that described health product are capsule, tablet or granule.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178760A (en) * | 2011-04-11 | 2011-09-14 | 海南京润珍珠生物技术股份有限公司 | Lipid regulating pearl capsule |
| CN102428832A (en) * | 2011-09-14 | 2012-05-02 | 大连百祥聚生物科技有限公司 | Fungal pharmaceutical mycoplasm with blood sugar lowering efficacy and preparation method thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1272368A (en) * | 2000-04-28 | 2000-11-08 | 谢申猛 | Selenium-enriched anka for reducing blood-fat and blood sugar |
| CN1173730C (en) * | 2002-08-13 | 2004-11-03 | 黄谷 | Blood fat-regulating medicine composition |
| CN100484539C (en) * | 2005-12-13 | 2009-05-06 | 文镜 | Functional food with blood sugar reducing action and its preparing method |
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2008
- 2008-09-09 CN CN200810215543XA patent/CN101347464B/en active Active
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178760A (en) * | 2011-04-11 | 2011-09-14 | 海南京润珍珠生物技术股份有限公司 | Lipid regulating pearl capsule |
| CN102178760B (en) * | 2011-04-11 | 2012-07-04 | 海南京润珍珠生物技术股份有限公司 | Lipid regulating pearl capsule |
| CN102428832A (en) * | 2011-09-14 | 2012-05-02 | 大连百祥聚生物科技有限公司 | Fungal pharmaceutical mycoplasm with blood sugar lowering efficacy and preparation method thereof |
| CN102428832B (en) * | 2011-09-14 | 2013-04-03 | 大连百祥聚生物科技有限公司 | Fungal pharmaceutical mycoplasm with blood sugar lowering efficacy and preparation method thereof |
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