CN101342212A - Medicament composition for preventing birth defection and improving memory - Google Patents
Medicament composition for preventing birth defection and improving memory Download PDFInfo
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- CN101342212A CN101342212A CNA2008101198870A CN200810119887A CN101342212A CN 101342212 A CN101342212 A CN 101342212A CN A2008101198870 A CNA2008101198870 A CN A2008101198870A CN 200810119887 A CN200810119887 A CN 200810119887A CN 101342212 A CN101342212 A CN 101342212A
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Abstract
The present invention provides a medicine composition for preventing birth defects and improving memory. The composition comprises largehead atractylode, white fungus, vitamin A, Beta- carotene, compound vitamin B, vitamin C, vitamin D, vitamin E and major elements of Ca and Mn, which is mainly suitable for pre-pregnant women, pregnant women and nannies. The present invention can effectively prevent birth defects and improve memory and at the same time has the efficacy of health care and invigoration without producing any side effect even for long-term use.
Description
Technical field:
The present invention relates to the Medicines and Health Product technical field; Pharmaceutical composition in particular for prevention birth defect and improvement memory.
Background technology:
Birth defect is meant fetus in parent and in the organ formative process of birth back, by embryo due to the various factors effect and paedomorphosis disorder, comprises that morphosis is unusual, 4 types of physiological metabolism obstacle, congenital mental retardation and intrauterine growth retardations etc.; Various countries' birth defect incidence rate is up to about 5% of the birth sum, and is great to the population quality influence, causes white elephant for family, society, become the common great public health problem of paying close attention in the present whole world.
The pathogenic factors of birth defect is very complicated, and inherited genetic factors is arranged, and environmental factors also has other multiple uncertain factor.Environmental factors comprises biological factor, physical factor, chemical factor; The embryo is subjected to the injury of environment harmful factor and other multiple uncertain factor, the birth defect sickness rate is increased, and eliminate these harmful factors, and the birth defect sickness rate is lowered.
Pharmaceutical composition of the present invention is a policy of following prenatal and postnatal care, by eliminating the birth defect factor that causes to the embryo, the generation of prevention birth defect reaches the purpose that lowers the birth defect sickness rate, simultaneously user there is the memory impairments of improvement, favourable mothers and sons two generations's health; Said composition comprises the Rhizoma Atractylodis Macrocephalae, Tremella, vitamin A, beta-carotene, compound vitamin B, vitamin C, vitamin D, vitamin E and macroelement calcium, magnesium.
The Rhizoma Atractylodis Macrocephalae is a kind of QI invigorating class natural Chinese medicine, and invigorating the spleen and benefiting QI is arranged, the dampness diuretic, the hidroschesis consolidating superficial resistance and in antiabortive effect; Ancient Chinese medicine is classified the Rhizoma Atractylodis Macrocephalae as on Chinese medicine product, antiabortive monarch drug, the panacea of fetus nourishing; The modern clinical cirrhotic ascites that are used for more, diarrhoea, Mo Niai syndrome, edema spontaneous perspiration, frequent fetal movement etc.; Modern pharmacological research confirms: 1, Rhizoma Atractylodis Macrocephalae Wheat Protein, can alleviate lipid peroxidation, reduce the content of peroxide, avoid the destruction of harmful substance pair cell 26S Proteasome Structure and Function, and SOD activity improving trend arranged, enhancing body is to the ability of free radical scavenging, thus the damage of minimizing radical pair body; 2, the Rhizoma Atractylodis Macrocephalae has delaying senility function, Rhizoma Atractylodis Macrocephalae decoct can improve the erythrocytic superoxide dismutase of aged mouse (SOD) activity, suppresses the brain activity of monoamine oxidase simultaneously, can also suppress erythrocytic autoxidation haemolysis, directly remove free radical, show anti-aging effects; 3, the Rhizoma Atractylodis Macrocephalae has the enhance immunity effect, and oral lymhocyte transformation rate and the serum IgG content of making of Rhizoma Atractylodis Macrocephalae decoct significantly rises, and shows that the Rhizoma Atractylodis Macrocephalae has immunostimulation, and can strengthen the vigor of macrophage, strengthens the phagocytic function of reticuloendothelial system; 4, anticancer tumor effect, Rhizoma Atractylodis Macrocephalae volatile oil has inhibitory action to murine sarcoma S180, and external have direct killing action to the ehrlich ascites tumor cell, and external the Eca109 esophageal cancer cell is presented inhibition, can make cell detachment, karyopycnosis, chromatin concentrates, and cell does not divide or seldom division; 5, the Rhizoma Atractylodis Macrocephalae also has the blood lipid-reducing blood sugar-decreasing effect, antibacterial action, and blood coagulation resisting function promotes the brood weight increase, physical potentiation raises to can be made leukocyte count by the leukopenia that causes after chemotherapy or the radiotherapy tumor; Traditional Chinese medical science custom in prescription the compatibility Rhizoma Atractylodis Macrocephalae with the absorption, particularly compatibility gold that promote the medicine active ingredient, stone class medicine to promote the absorption and the utilization of mineral; The Rhizoma Atractylodis Macrocephalae is the article that can be used for health food.
Tremella be a kind of be food also be the nourishing YIN class natural Chinese medicine of medicine, nourishing YIN and moistening the lung is arranged, the effect of supplementing QI for promoting the production of body fluid; The clinical chronic tracheitis that is used for the treatment of, pulmonary heart disease, leukopenia etc.; Modern pharmacological research confirms that Tremella has: 1, raise immunity, and Tremella pair cell and humoral immunization and non-specific immunity all have potentiation; 2, antitumor action, tremella polysaccharide is by the human body immunity improving function, strengthen the reticuloendothelial system phagocytic function, promote the generation of IFN, TNF etc., the effect of indirect anticancer is arranged, tremella polysaccharide can alleviate the toxicity of chemotherapy and radiation again, heightens the effect of a treatment, and improves cancer patient's life quality and prolongs life cycle; 3, anti-aging effects, tremella polysaccharide can reduce lipofuscin content in the fruit bat body and obviously prolong the average life of fruit bat, can obviously reduce mouse cardiac muscle again and organize lipofuscin content, strengthen superoxide dismutase activity in mouse brain and the hepatic tissue, suppress MAOB activity in the brain, prolong mice life cycle under anaerobic conditions; 4, antimutagenic effect, tremella polysaccharide can resist the mouse bone marrow cells micronuclear rates increase that cyclophosphamide causes, prevent that the lymphocyte chromosome of exposure animal from distorting; 5, blood fat reducing, hypoglycemic activity; 6, promote protein and biological nucleic acid anabolic effect, 7, also have effects such as anticoagulation, antithrombotic, antiulcer, antiinflammatory, protection erythrocyte membrane, protection cardiovascular system in addition.
Vitamin A also claims retinol, and the effect that improves vision, prevents nyctalopia is arranged, and the anemia of pregnant woman of enhancing Abwehrkraft des Koepers function is arranged, and can promote mucopolysaccharide synthetic, influences renewal, the growth of osseous tissue, and long bone is grown to both-end; If vitamin A deficiency is prone to premature labor or fetal congenital deformity; Beta-carotene can change vitamin A under the effect of enzyme in vivo, the effect of performance vitamin A.
Vitamin B group participates in body internal protein, fat and sugar metabolism, makes the excitement of brain cell and inhibition be in poised state, and it comprises vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid etc., collaborative in vivo performance physiological action.Vitamin B
1Have the effect of keeping the nervous system normal function, phenomenon such as it is incomplete to occur carbohydrate metabolism during shortage, and heat energy is under-supply, thus cause hypomnesis, influence the normal function of brain, if vitamin B
1Abundance can effectively form the energy of brain cell activity necessity, but improving memory, concentration power and learning capacity, vitamin B in addition
1Suppress cholinesterase in addition, improve the function of cholinergic nerve; Vitamin B
2Having another name called riboflavin, is the ingredient of many important coenzyme in the body, and it participates in intravital substance metabolism, promotes fetus and baby's growth promoter to play an important role vitamin B to the activity that earns a bare living
2Be to keep skin and the requisite vitamin of eye health, anemia of pregnant woman's vitamin B
2Lack or can not cause or inspire pregnant early pregnancy completely and vomit, second trimester angular cheilitis, glossitis, cheilitis and premature infant's incidence rate increase; Nicotiamide claims niacin amide or vitamin PP again, and its physiological function is to participate in the body intracellular metabolic, keeps normal neurological function, and pellagra can take place during shortage in synthesizing of assurance gonadal hormone etc., mainly shows as dermatitis, diarrhoea, dull-witted three big symptoms; Pantothenic acid extensively exists in each organism, participates in metabolic activity widely, and known have 70 plurality of enzymes all to need pantothenic acid to participate in all kinds of biochemical reaction of catalysis body, otherwise just can Metabolic disorder; Biotin also is a kind of vitamin B group, coordinates to participate in the metabolism of human body matter and energy with other vitamin B group, and it is synthetic with nucleic acid, and the compositive relation of gonadal hormone is close, and it also has control poliosis, bareheaded effect; Vitamin B
6Most important to the maincenter neurodevelopment, if shortage can make the nervus centralis hypoevolutism, intelligence descends, and it has the assistance vitamin B
1Effect, be the vitamin that can improve concentration power and stimulate desire learn; Vitamin B
12Participate in nucleic acid in vivo, choline, amino acid whose synthetic and fat and sugared metabolism, to hemopoietic function of bone marrow, the gastrointestinal epithelial cells function, liver function and nervous system myelin functional integrity have certain effect, it is the necessary vitamin of intelligence of bringing into normal play, not only cause dysnoesia if lack, also nutritional anemia can occur, influence is to blood supply in the brain; Folic acid participates in the synthetic of aminoacid and nucleic acid, and and vitamin B
12The common generation that promotes cell is with ripe, and normal cell can not carry out mitosis during shortage, the neurological symptom can occur, as: the loss of memory, depression and dementia etc.; Human body can be at vitamin B in addition
12Under the effect of folic acid as cofactors, by serine of taking in and the synthetic choline of methionine, choline is the key component of acetylcholine, and acetylcholine is an important neurotransmitter in the human body; Folic acid, vitamin B are arranged again
6And vitamin B
12Can work in coordination with and remove the intravital homotype cysteine of people, the homotype cysteine is a kind of neurotoxin, can cause the self murder of brain; There are some researches show that homocysteine is a kind of potential teratogen of independently growing, and is related closely with congenital heart disease and neural tube defects; Homocysteine also can cause miscarriage, premature labor in addition, clinical disastrous effect such as preeclampsia.
Vitamin C claims ascorbic acid again, vitamin C and collagen in close relations, the vessel softening effect is not only arranged, the effect that purifies the blood in addition, prevent arteriosclerosis, can also promote the absorption of human body, for hemopoietic provides essential raw material ferrum in the food, simultaneously, vitamin C regain one's strength, aspect effect such as allaying tiredness, keeping tensions down emotion is obvious; Pregnancy duration, subcutaneous hemorrhage can appear in anemia of pregnant woman's hypovitaminosis C or deficiency, swelling and aching of gum, symptom such as bleed, fester, the long-term lacking vitamin C easily has virus flu, and increases the danger of fetus teratogenesis, and famine can cause miscarriage.
Vitamin D is the sterols derivant, and the subcutaneous dehydrocholesterol of human body produces vitamin D through ultraviolet radiation
3, ergosterol produces vitamin D behind ultraviolet radiation
2, the two originates different, the function unanimity, and the importance of vitamin D is to regulate the metabolism of calcium and phosphorus in human nutrition; Vitamin D promotes calcium in little intestinal absorption, the then a large amount of calcium of the D that is deficient in vitamin are discharged by feces, thereby cause the human body calcium deficiency, and rickets can take place the child, become the calcium phosphorus of storing in the human body to exhaust and can cause osteomalacia, modal osteomalacia crowd is anemia of pregnant woman, wet nurse and old people.
Vitamin E is all general designations with the bioactive chromone derivative of alpha-tocopherol, wherein the activity of alpha-tocopherol is the highest, have the effect of eliminating free radical, slow down aging, prevention maxicell hemolytic anemia, medically often adopting vitamin E treatment male and female infertility and threatened abortion; Vitamin E deficiency or anemia of pregnant woman's reproductive system is suffered damage, irreversible variation takes place in germinal epithelium, in addition, phenomenons such as maxicell hemolytic anemia and red blood cell life span shortening can take place also.
Calcium is the macroelement that body weight for humans is wanted, and mainly plays two aspects, the one, constitute sclerous tissueses such as bone tooth; The 2nd, constitute the material of specific function with protein bound or with the form of calcium ion, form in so-called miscible calcium pool and the bone tooth calcium and keep dynamic equilibrium, all cells all need its normal function of calcium competence exertion in the body; Anemia of pregnant woman and wet nurse's calcium deficiency can influence the growth of its body constitution and fetus or infant, and calcium deficiency can cause that also endocrine dysfunction and cell cycle regulation are malfunctioning, and anemia of pregnant woman and wet nurse are owing to physiological characteristics, the Deficiency of Intake of ubiquity calcium.
Magnesium topmost function in human body is the generation of containment free radical, and free radical is short old and feeble factor, also is the factor that mainly causes birth defect; Another function of magnesium is to bring into play the effect of protection skeleton with calcium and vitamin D, and osteoporosis takes place magnesium deficiency easily, fractures easily; Magnesium is protected heart in addition and is prevented and treated the function etc. of diabetes in addition.
Application contains the Rhizoma Atractylodis Macrocephalae, Tremella, vitamin A, beta-carotene, vitamin B
1, vitamin B
2, vitamin B
6, nicotiamide, pantothenic acid, biotin, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E and macroelement calcium, magnesium has been known as the compositions of active component, but with the Rhizoma Atractylodis Macrocephalae, Tremella, vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E and macroelement calcium, the magnesium compatibility pharmaceutical composition that is used for prenatal and postnatal care prevention birth defect and improves memory report as yet.
Current medicine that is used to improve memory or health food kind have multiple, but aim at pregnant before the medicine or the health food that are used to improve memory of women, anemia of pregnant woman, wet nurse's development do not see as yet; Do not see the medicine label that is used to prevent birth defect as yet, rarely seen report that folic acid prevention neural tube defects is arranged; But its target spot is few, and the link shortcoming needs perfect.And will prevent the effect of birth defect and improvement memory and be used for same medicine person not see as yet.
Summary of the invention:
In order to overcome existing prevention birth defect and/or to improve the shortcoming and defect of remembering medicine, the purpose of this invention is to provide a kind of compositions, said composition promotes the absorption and the utilization of vitamin, mineral by the Rhizoma Atractylodis Macrocephalae, and with collaborative vitamin A, beta-carotene, the vitamin B of increasing of Tremella
1, vitamin B
2, vitamin B
6, nicotiamide, pantothenic acid, biotin, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E and macroelement calcium, magnesium improves the effect of memory and prevention birth defect, simultaneously by macroelement calcium, magnesium and vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E, replenish and strengthen the effect of the antiabortive and Rhizoma Atractylodis Macrocephalae of Rhizoma Atractylodis Macrocephalae fetus nourishing and Tremella antioxidation, defying age, antitumor, blood lipid-reducing blood sugar-decreasing, mutation, enhance immunity; Even chronic administration is also without any side effect.Because the result of broad research, the inventor have found the Rhizoma Atractylodis Macrocephalae and Tremella, vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E and macroelement calcium, magnesium novel combination, this novel combination is for the prevention birth defect and improve memory synergy is arranged; And singly use the Rhizoma Atractylodis Macrocephalae and Tremella, vitamin A, beta-carotene, compound vitamin B, vitamin C, vitamin D, vitamin E and macroelement calcium, magnesium, its effect is all not as good as this compositions; And the effective ingredient of each component has the addition complementary action to the health care tonification of human body, as the Rhizoma Atractylodis Macrocephalae of the used dosage of this compositions have that fetus nourishing is antiabortive, the effect of defying age, enhance immunity, physical strength reinforcing; Tremella has the effect of nourishing YIN and moistening the lung, supplementing QI for promoting the production of body fluid; Vitamin A has the raising vision, prevents the effect of nyctalopia; Vitamin B
1Can prevent and treat vitamin B1 deficiency, keep the normal activity of nerve, digestion, muscle, blood circulation; Vitamin B
2Be to keep skin and the requisite vitamin of eye health; Pellagra can take place in nicotinamide deficiency; The pantothenic acid shortage can cause Metabolic disorder; Biotin can be prevented and treated poliosis, alopecia; Vitamin B
6Can eliminate intraepithelial neoplasia cells, raise immunity, the protection blood vessel; Vitamin B
12Be used for various megaloblastic anemias and neural disease; Folic acid is protected heart and antitumaous effect in addition; Vitamin C has vessel softening, purifies the blood, prevents arteriosclerotic effect; Vitamin E has the free radical of removing, function in delaying senility; Macroelement calcium, magnesium and vitamin D are brought into play the effect of protection skeleton jointly; There is not incompatibility in this compositions, have no side effect, and cost is low, thereby constitutes the present invention.
The invention provides the compositions that is used to prevent birth defect and improves memory, it comprises as the Rhizoma Atractylodis Macrocephalae of active component and Tremella, vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E and macroelement calcium, magnesium.
The Rhizoma Atractylodis Macrocephalae is the Compositae herbaceos perennial Rhizoma Atractylodis Macrocephalae (Atractylodes macrocephala koidz) rhizome.Main product in Zhejiang, ground such as Hubei, Hunan.Gather winter, dries or dry, and life usefulness or parching with earth, parched with bran are used.The used Rhizoma Atractylodis Macrocephalae of the present invention can be with its extract as raw material.
Tremella is the sporophore of Basidiomycetes Tremellaceae Tremella Tremella fuciformis Berk; Wild less, now mostly be artificial culture, auricle is opened when stopping growing together and is gathered, and dries or dries after the clear water rinsing; Main product in Sichuan, ground such as Yunnan, Fujian, Hubei, Anhui, Zhejiang, Guangxi, Shaanxi, Taiwan, the most famous with Tongjiang, Sichuan Tremella, ZhangZhou, Fujian Tremella; The used Tremella of the present invention can be with its extract as raw material.
Be used for vitamin B of the present invention
1(VitaminB
1), vitamin B
2(VitaminB
2), nicotiamide (Nicotinamide), pantothenic acid (Pantothenic Acid), biotin (Vitamin H), vitamin B
6(VitaminB
6), vitamin B
12(VitaminB
12), folic acid (Folic Acid), vitamin C (VitaminC), all are water soluble vitamins, do not accumulate in vivo; Vitamin A (Vitamin A), vitamin D (Vitamin D), vitamin E (Vitamin E) are fatsoluble vitamiies, and beta-carotene (Beta Carotene) is the precursor substance of vitamin A, and be useful and harmless by the used dosage of the present invention; Calcium (Ca), magnesium (Mg) are the macroelements of needed by human; Macroelement calcium among the present invention can be selected calcium gluconate, calcium acetate, calcium caseinate, calcium chloride, calcium citrate, calcium malate, calcium cirate malate, calcium hydrogen phosphate, dalcium biphosphate, calcium phosphate, calcium sulfate, calcium ascorbate, calcium glycerophosphate, calcium lactate, calcium carbonate etc. for use, macroelement magnesium can be selected magnesium chloride, magnesium gluconate, magnesium citrate, magnesium hydrogen phosphate, magnesium phosphate, magnesium glycerophosphate, magnesium lactate, magnesium carbonate etc. for use, and professional production factory and supplier are all arranged.
Compositions of the present invention mainly is applicable to women in pregnant early stage, anemia of pregnant woman and wet nurse; Be subjected to the influence of factors such as geology, food chain, dietetic life custom and Time of Administration length, the effective dose that the crowd that benefits from benefits from this compositions each component has certain difference; By the present invention, the effective dose of Rhizoma Atractylodis Macrocephalae extract is counted 300-15000mg/ days with whole crude drug, and the effective dose of Tremella extract is counted 300-10000mg/ days with whole crude drug, vitamin B
1Effective dose be 0.5-20mg/ days, vitamin B
2Effective dose be 0.5-20mg/ days, the effective dose of nicotiamide is 5-50mg/ days, the effective dose of pantothenic acid is 2-20mg/ days, the effective dose of biotin is 0.01-0.1mg/ days, vitamin B
6Effective dose be 0.5-10mg/ days, vitamin B
12Effective dose be 0.001-0.025mg/ days, the effective dose of folic acid is 0.1-1mg/ days, ascorbic effective dose is 30-500mg/ days, the effective dose of vitamin A and/or beta-carotene (in retinol equivalent) is 250-800 μ gRE/ days; The effective dose of vitamin D is 0.0015-0.01mg/ days, the effective dose of vitamin E (in the alpha-tocopherol equivalent) is 5-150mg α-TE/ days, the effective dose of macroelement calcium is counted 250-1000mg/ days with element calcium, and the effective dose of magnesium is counted 100-300mg/ days with element magnesium.
Compositions of the present invention can or directly be taken by following pharmaceutical dosage forms dispenser, for example, oral formulations is (as granule, powder, capsule, ball, sheet, dry syrup, liquid formulation), or food such as food (as cookies), mix and prepare with other known additives, this class additive is for example: carrier, disintegrating agent, slow releasing agent, excipient, filler, covering, binding agent, lubricant, antioxidant, apply agent, coloring agent, correctives, sweeting agent, sucrose succedaneum, nutrition enhancer, flavouring agent, surfactant, plasticizer, the PH regulator, freshener, suspending agent, defoamer, antiseptic, thickening agent, solubilisation aids etc. are prepared or they are added food as functional component or additive by usual way.
By the present invention, the Rhizoma Atractylodis Macrocephalae, Tremella, vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E and macroelement calcium, magnesium each component can distinguish preparation, the preparation of each component can be mixed the back when using and use or do not mix simultaneously and use.
Advantage of the present invention is that this compositions is eliminated the multiple factor that causes birth defect and cause hypomnesis from too many levels, multisystem, many target spots, the effect of collaborative performance effect is arranged between the each component, prevention birth defect and improvement memory there is significant effect, sufficient raw, cost is low, and each component has no side effect in the compositions, no incompatibility, except that prevention birth defect and improvement memory, human body still there is the health care benefiting action.
Subordinate list 1 is this compositions and the Rhizoma Atractylodis Macrocephalae and Tremella component and the young rat/mouse labyrinth test effect comparison of vitamin added elements component.
Subordinate list 2 is this compositions and the Rhizoma Atractylodis Macrocephalae and Tremella component and the comparison of vitamin added elements component Aged Mice maze test effect.
Relatively tabulate below with reference to embodiment and test implementation example effect and to be described in detail the present invention.
Embodiment 1:
Rhizoma Atractylodis Macrocephalae 2000mg,
Tremella 500mg,
Folic acid 0.3mg,
Vitamin B
62mg,
Vitamin B
120.003mg,
Calcium lactate (in element calcium) 600mg,
Magnesium lactate (in element magnesium) 200mg.
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 2:
Rhizoma Atractylodis Macrocephalae 2000mg,
Tremella 500mg,
Folic acid 0.3mg,
Vitamin B
62mg,
Vitamin B
120.003mg,
Vitamin B
13mg,
Vitamin B
23mg,
Nicotiamide 10mg,
Calcium lactate (in element calcium) 600mg,
Magnesium lactate (in element magnesium) 200mg.
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 3:
Rhizoma Atractylodis Macrocephalae 2000mg,
Tremella 500mg,
Folic acid 0.3mg,
Vitamin B
62mg,
Vitamin B
120.003mg,
Vitamin B
13mg,
Vitamin B
23mg,
Nicotiamide 10mg,
Vitamin C 30mg,
Calcium lactate (in element calcium) 600mg,
Magnesium lactate (in element magnesium) 200mg,
Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules
Embodiment 4:
Rhizoma Atractylodis Macrocephalae 2000mg,
Tremella 500mg,
Folic acid 0.3mg,
Vitamin B
62mg,
Vitamin B
120.003mg,
Vitamin B
13mg,
Vitamin B
23mg,
Nicotiamide 10mg,
Vitamin C 30mg,
Calcium lactate (in element calcium) 600mg,
Magnesium lactate (in element magnesium) 200mg,
Retinol equivalent (vitamin A and/or beta-carotene) 300 μ g RE,
Vitamin D 0.002mg,
Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, again the gained mixture is made 3 bag shot-like particles.Obey every day 3 times, obey a bag at every turn.
Embodiment 5:
Rhizoma Atractylodis Macrocephalae 300mg,
Tremella 300mg,
Folic acid 0.1mg,
Vitamin B
60.5mg,
Vitamin B
120.001mg,
Vitamin B
10.5mg,
Vitamin B
20.5mg,
Nicotiamide 5mg,
Pantothenic acid 2mg,
Biotin 0.01mg,
Vitamin C 30mg,
Calcium lactate (in element calcium) 250mg,
Magnesium lactate (in element magnesium) 100mg,
Retinol equivalent (vitamin A and/or beta-carotene) 250 μ g RE,
Vitamin D 0.0015mg,
Vitamin E (in the alpha-tocopherol equivalent) 5mg α-TE.
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, again the gained mixture is made 3 bag shot-like particles.Obey every day 3 times, obey a bag at every turn.
Embodiment 6:
Rhizoma Atractylodis Macrocephalae 15000mg,
Tremella 10000mg,
Folic acid 1mg,
Vitamin B
610mg,
Vitamin B
120.025mg,
Vitamin B
120mg,
Vitamin B
220mg,
Nicotiamide 50mg,
Pantothenic acid 20mg,
Biotin 0.1mg,
Vitamin C 500mg,
Calcium lactate (in element calcium) 1000mg,
Magnesium lactate (in element magnesium) 300mg,
Retinol equivalent (vitamin A and/or beta-carotene) 800 μ g RE,
Vitamin D 0.01mg,
Vitamin E (in the alpha-tocopherol equivalent) 150mg α-TE.
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, again the gained mixture is made 3 bag shot-like particles.Obey every day 3 times, obey a bag at every turn, serve on 10, at interval 30 taking medicine twice a days.
Confirm that through animal experiment this compositions belongs to nontoxic level; The crowd takes and does not also see toxicity.
Subordinate list 1: the young rat/mouse labyrinth test effect of this compositions and the Rhizoma Atractylodis Macrocephalae and Tremella component and vitamin added elements component compares:
| Group | Medicine | Consumption | Sample number | The mistake percentage rate |
| The A group | Matched group | 0 | 12 | 21.6％ |
| The B group | The Rhizoma Atractylodis Macrocephalae and Tremella group | Rhizoma Atractylodis Macrocephalae 100mg+ Tremella 50mg/ days | 12 | 18.9％ |
| The C group | Vitamin+element set | Calcium 10mg+ magnesium 5mg+VB 60.08mg +VB 120.0001mg+ folic acid 0.008mg/ days | 12 | 16.1％ |
| The D group | The Rhizoma Atractylodis Macrocephalae and Tremella+vitamin+element set | Rhizoma Atractylodis Macrocephalae 100mg+ Tremella 50mg+ calcium 10mg+ magnesium 5mg+VB 60.08mg +VB 120.0001mg+ folic acid 0.008mg/ days | 12 | 15.6％ |
Subordinate list 2: this compositions and the Rhizoma Atractylodis Macrocephalae and Tremella component and vitamin added elements component Aged Mice maze test effect compare:
| Group | Medicine | Consumption | Sample number | The mistake percentage rate |
| The A group | Matched group | 0 | 12 | 53.3％ |
| The B group | The Rhizoma Atractylodis Macrocephalae and Tremella group | Rhizoma Atractylodis Macrocephalae 100mg+ Tremella 50mg/ days | 12 | 35％ |
| The C group | Vitamin+element set | Calcium 10mg+ magnesium 5mg+VB 60.08mg +VB 120.0001mg+ folic acid 0.008mg/ days | 12 | 32.3％ |
| The D group | The Rhizoma Atractylodis Macrocephalae and Tremella+vitamin+element set | Rhizoma Atractylodis Macrocephalae 100mg+ Tremella 50mg+ calcium 10mg+ magnesium 5mg+VB 60.08mg +VB 120.0001mg+ folic acid 0.008mg/ days | 12 | 30.3％ |
Annotate: each group was tested by dosage feed in the table respectively in 60 days in subordinate list 1, the subordinate list 2; Consumption converts by per kilogram of body weight in the table; Calcium, magnesium are in element.
Select 50 of newly-married healthy womens, 25 years old mean age, take this compositions continuously from beginning in pregnant preceding 3 months, followed up a case by regular visits to none routine birth defect in 6 months to the baby due.With associated materials statistics contrasts, birth defect youngster accounts for the 4-6% of newborn population sum, and there were significant differences.
Can obviously find out from table 1, table 2, this compositions is by Chinese medicine component in rat/mouse labyrinth test and the compositions and the contrast of vitamin added elements component, the statistical result of mistake percentage rate, the function of this composition for improved memory is better than Chinese medicine component or vitamin added elements component; With the blank group significant difference is arranged relatively.
Claims (5)
1, a kind of pharmaceutical composition that is used to prevent birth defect and improves memory is characterized in that it is made by weight ratio by following raw materials according:
Rhizoma Atractylodis Macrocephalae 300-15000mg,
Tremella 300-10000mg,
Folic acid 0.1-1mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10-20mg,
Vitamin B
20-20mg,
Nicotiamide 0-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Vitamin C 0-500mg,
Calcium 250-1000mg,
Magnesium 100-300mg,
Retinol equivalent [vitamin A and/or beta-carotene] 0-800 μ gRE,
Vitamin D 0-0.01mg,
Vitamin E 0-150mg a-TE.
2, the pharmaceutical composition that is used to prevent birth defect and improves memory according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:
Rhizoma Atractylodis Macrocephalae 300-15000mg,
Tremella 300-10000mg,
Folic acid 0.1-1mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10.5-20mg,
Vitamin B
20.5-20mg,
Nicotiamide 5-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Vitamin C 0-500mg,
Calcium 250-1000mg,
Magnesium 100-300mg,
Retinol equivalent [vitamin A and/or beta-carotene] 0-800 μ gRE,
Vitamin D 0-0.01mg,
Vitamin E 0-150mg a-TE.
3, the pharmaceutical composition that is used to prevent birth defect and improves memory according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:
Rhizoma Atractylodis Macrocephalae 300-15000mg,
Tremella 300-10000mg,
Folic acid 0.1-1mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10.5-20mg,
Vitamin B
20.5-20mg,
Nicotinoyl 5-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Vitamin C 30-500mg,
Calcium 250-1000mg,
Magnesium 100-300mg,
Retinol equivalent [vitamin A and/or beta-carotene] 0-800 μ gRE,
Vitamin D 0-0.01mg,
Vitamin E 5-150mg a-TE.
4, the pharmaceutical composition that is used to prevent birth defect and improves memory according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:
Rhizoma Atractylodis Macrocephalae 300-15000mg,
Tremella 300-10000mg,
Folic acid 0.1-1mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10.5-20mg,
Vitamin B
20.5-20mg,
Nicotiamide 5-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Vitamin C 30-500mg,
Calcium 250-1000mg,
Magnesium 100-300mg,
Retinol equivalent [vitamin A and/or beta-carotene] 250-800 μ gRE,
Vitamin D 0.0015-0.01mg,
Vitamin E 5-150mg a-TE.
5, the pharmaceutical composition that is used to prevent birth defect and improves memory according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:
Rhizoma Atractylodis Macrocephalae 300-15000mg,
Tremella 300-10000mg,
Folic acid 0.1-1mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10.5-20mg,
Vitamin B
20.5-20mg,
Nicotiamide 5-50mg,
Pantothenic acid 2-20mg,
Biotin 0.01-0.1mg,
Vitamin C 30-500mg,
Calcium 250-1000mg,
Magnesium 100-300mg,
Retinol equivalent [vitamin A and/or beta-carotene] 250-800 μ gRE,
Vitamin D 0.0015-0.01mg,
Vitamin E 5-150mg a-TE.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101198870A CN101342212A (en) | 2008-09-16 | 2008-09-16 | Medicament composition for preventing birth defection and improving memory |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101198870A CN101342212A (en) | 2008-09-16 | 2008-09-16 | Medicament composition for preventing birth defection and improving memory |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101342212A true CN101342212A (en) | 2009-01-14 |
Family
ID=40244403
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2008101198870A Pending CN101342212A (en) | 2008-09-16 | 2008-09-16 | Medicament composition for preventing birth defection and improving memory |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101342212A (en) |
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2008
- 2008-09-16 CN CNA2008101198870A patent/CN101342212A/en active Pending
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Open date: 20090114 |