CN101337089A - Muscle regeneration factor - Google Patents
Muscle regeneration factor Download PDFInfo
- Publication number
- CN101337089A CN101337089A CNA200710122922XA CN200710122922A CN101337089A CN 101337089 A CN101337089 A CN 101337089A CN A200710122922X A CNA200710122922X A CN A200710122922XA CN 200710122922 A CN200710122922 A CN 200710122922A CN 101337089 A CN101337089 A CN 101337089A
- Authority
- CN
- China
- Prior art keywords
- muscle regeneration
- injection
- regeneration factor
- garment
- folds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The invention relates to a muscle regeneration agent, which belongs to the field of the plastic surgery. The muscle regeneration agent is an injection-type muscle regeneration agent which is prepared by the following steps: under the protection of the cell wall-degraded fusion agent, newt cells with regeneration ability in the animal kingdom are fused with the wall-degraded cells of tested mice to realize the growth of bulgy histiocytes, the histiocytes growing after the fusion of degraded cell walls of newt cells are further accepted, and are prepared into the injection-type muscle regeneration agent with the cell wall-degraded fusion agent and the injection solvent after in vitro expansion. The muscle regeneration agent can be used for nose augmentation, chin augmentation and breast augmentation by the injection method (in one or more steps) in the plastic surgery. Muscle tissues can grow and bulge at the injection positions to the designed effect after injection. The injection method can also be applied to eliminating wrinkles and avoiding wrinkles from appearing in a long term.
Description
Technical field
Muscle regeneration factor of the present invention belongs to field of orthopedic surgery.
The present invention relates in the plastic surgery, muscle regeneration factor is injected into the position that needs protuberance.Allow its growth protuberance reach the complete position of beauty treatment design effect.As: augmentation rhinoplasty, grand chin, enlarge the bosom etc.Muscle regeneration factor of the present invention is orthopedic new material.
Background technology
Liking to be beautiful is human nature, and human pursuit to U.S. is the symbol of social progress.Late period in 19th century, sexually transmitted disease (STD) was popular in generation, severe complications.Make that a lot " truly great person " the nasus incurvus deformity has taken place.Make original appearance become ugly especially, the patient of some saddle nose deformities, also the same with the syphilis nose, be subjected to the discrimination of society, they treat in an urgent demand. to extricate oneself from a predicament.
Since 20th century, begun with augmentation rhinoplasty, augmentation rhinoplasty, the plastic surgery of swelling chin, enlarging the bosom arise at the historic moment, and what the plastic surgery at first ran into is the difficult problem what increases the position that need increase with.The plastic surgery adopted omnifarious material as vaseline, paraffin, plastics, Dens Elephatis, lucite, gutta-percha, platinum, gold, silver, animal bone, artificial bone, allograph bone, from body bone, liquid silica gel or the like at the very start.Start from once boffo injection paraffin oil in 1904, just problem occurred soon.Paraffin oil not only zest is too big, and tissue is had strong complaints, and winter is inflammable roasting, summer, fearness was exposed to the sun, and moulding ability is because tissue reaction, grow paraffinoma, must operate on and to take out, behind the injection paraffin oil, what have flows to abdominal part, thigh even ankle downwards with gravity, form multiple paraffinoma on the way, stay serious sequela, cause repent forever, cause many operation receiveing persons to be marred by a scar, etc. and disfeature, the injection paraffin oil has been eliminated soon.After this someone thinks: augmentation rhinoplasty, grand chin, use from the body bone preferably, absorptions of can not being ostracised has no side effect, and safety is relieved, can and tissue grow together, maintenance is lifelong.But in practice, from the body bone many shortcomings are arranged also, the mankind are operational mainly to be hipbone, rib and costicartilage.Will have an operation from human body and take out a bone and come, operation is painful relatively big, and the time is long, and hipbone, rib, and sclerotin is hard, and is bad moulding, costicartilage thickness low LCL, moulding difficulty.Can not reach surgical effect.A lot of materials all are unable to undergo the practice use and are eliminated.
Along with the development of chemical industry, 1963, the high-tech organic compound silicone rubber of synthetic occurred, through zoopery, clinical trial, silica gel can be made (as solid block, shaping prosthese) silica gel goods of various trait, the beauty treatment position that implant into body need swell according to different needs.Macromolecule silica gel physicochemical property is stable, good biocompatibility.To human body nontoxicly, harmless do not absorb, indeformable, the source is abundant, can produce in batches.
Since 1963, augmentation rhinoplasty, grand chin, the material of enlarging the bosom have just had only silica gel.Use the silica gel prosthese to carry out shaping and beauty.Must just can carry out by operation: augmentation rhinoplasty is from a side nose Xiao Gui edge; Grand chin in mouth or mouthful outside under the chin; Mamaplasty has five positions to select, areola edge, breast lateral border, crowfoot cracks place before the crowfoot cracks invagination under the breast, axil, axillary fossa top (all there are pluses and minuses in each one); Make little otch, go deep into nose, bridge of the nose, the nasion (augmentation rhinoplasty) along otch by vascular forceps; Chin portion (grand chin) is behind the mammary gland of breast center or under the pectoralis major (mamaplasty); Move under water and isolate the lacuna that holds prosthese, by otch prosthese is implanted, ajust, sew up the incision, operation just can be finished like this.
Operation must be the process of bleeding, and is painful, and is risky.Moreover what implant is prosthese after all, is that foreign body, time are long more, and easy more generation prostheses migration wears out, breaks, needs turnover rate just big more.
In order to seek nonoperative plastic surgery's means, people also did all trials.Such as: injection autologous fat granule, this was the good method of killing two birds with one stone originally, and the position of piling up from local fat pumps out lipochondrion, and one side reaches reducing weight and beautifying features, the one side twice laid, simple, safety, no foreign body reaction, wound is little, recovery is fast, non-incision, does not stay the operation vestige.But the granule of implanting is nonviable, can absorb gradually after the liquefaction and necrosis to excrete, and that absorbance is good is 30-60%, and that bad is 70-80%.And for example inject creotoxin, effect duration has only 4-8 month; The injection hyaluronic acid, effect duration also has only 6-12 month.Want to keep effect, just must intermittence execute notes, bear risk again and again.
Be located in " the national organizational project " center " of black bamboo high-tech park, Minhang, Shanghai; Chief scientist professor Cao Yilin says, here will set up special biomedical factory an of family, people can purchase own needed any histoorgan in advance in this factory, and the expert gets a fritter histiocyte from the normal human, allow it in external a large amount of amplifications, Hui Zhi is to the position that needs to repair again.Promptly " seed cell " is expelled to the beauty treatment position that nose, chin etc. need protuberance, allows it grow the tissue that needs.
In the plastic surgery, people are pursuing the beauty treatment position that a kind of material is injected into needs protuberance always, allow it grow the tissue that needs, and have no resolution all the time so far unfortunately.
Muscle regeneration factor of the present invention is the optimal material earnestly sought over more than hundred year of people just.
Summary of the invention
The invention reside in the newt cell that has regeneration capacity with regnum animale, secondary and experimental mouse cell take off folds in a garment and merge the protuberance histiocyte grow, behind amplification in vitro, and take off folds in a garment fusion agent, injection solution, make the muscle regeneration factor of injection type.Then it is injected into the position that human body need swell, allows it grow the tissue that reaches design effect, muscle regeneration factor of the present invention in the plastic surgery, can reach cosmetic results such as augmentation rhinoplasty, grand chin, mamaplasty with injection.
Muscle regeneration factor of the present invention is injected into the wrinkle position, and the rift grain road is floating, has removed wrinkle, and original wrinkle can not reproduced for a long time, accomplish that the operation receiveing person resides permanently in the youth, appearance does not wane.
Use muscle regeneration factor of the present invention, lack (recessed) that can remedy or repair any position of human body falls into.Mould beautiful body again.
Muscle regeneration factor of the present invention is characterised in that the muscle regeneration factor of the present invention that injects human body, can merge with the muscle cell of receptor, be that the folds in a garment of cell outside dissolves away and just makes the cell merging, the merging of having taken off the cell of folds in a garment promptly is the merging of protoplast, the merging of protoplast has produced new cell, thereby the cell that makes muscle regeneration factor of the present invention and receptor carries out a series of folds in a garment that takes off to be merged, and merges to grow new muscular tissue.Thereby making the position of receptor protuberance is the muscular tissue of receptor autophosphorylation.Be different from the material of shaping protuberance in the past, the overwhelming majority is the foreign body prosthese.
Feature of the present invention also is, the newt cell secondary and the experimental mouse cell that have regeneration capacity with regnum animale take off the cell that the folds in a garment fusion grows protuberance, behind the amplification in vitro, with take off the folds in a garment fusion agent, injection solvent, make the injection type muscle regeneration factor, wherein be furnished with remove the rejection effect take off folds in a garment fusion agent (not being to have ciclosporin commonly used in the present organ transplantation of peculiar immunologic rejection ability).Merge thereby make the present invention can take off folds in a garment, be merged into new cell with any race's human body cell.Without any rejection property, the present invention is suitable for any race's human body and the carcass cell fusion of any animal merges the new tissue of generation.
The specific embodiment
The object of the present invention is achieved like this: the present invention is subjected to world technology achievement (in December, 1999, U.S. scientist finds that the adult stem cell of mouse muscle tissue can " laterally differentiation " be blood cell, this discovery discovers further that at once by after scientist's confirmation all over the world the human adult stem cell has the function of " laterally differentiation " equally; In JIUYUE, 2000, Italian scientist successfully cultivates muscle cell with the neural stem cell of adults; In February calendar year 2001, Chinese science man Cao Yi woods is cultivated people's ear on the rabbit ear; In JIUYUE, 2005, in the symposium on academic subjects that Cambridge University holds, expert from U.S. Wei Sita institute discloses: first has being called as of superpower regeneration capacity in the world: " the miracle mouse " of " MRL " Mus kind, can grow " the nearly all organ " that comprise heart on one's body again, after the fetal liver cells that " miracle mouse " extracted is expelled in the common mouse body, also can obtain regeneration capacity miraculously on one's body) inspire.The newt cell that under the protection of taking off the folds in a garment fusion agent, regnum animale is had limb regeneration; merge the tissue that grows protuberance with the experimental mouse muscle cell; accept the newt cell once more; take off the folds in a garment fusion and grow the protuberance histiocyte; behind the amplification in vitro, cooperate the muscle regeneration factor that takes off folds in a garment fusion agent, injection solvent, makes injection type of the present invention.
With muscle regeneration factor of the present invention, be coated in the about 2cm that is tried Mus
2Wound surface on, the wound decrustation of in 42h, healing fully, but stay muscular tissue on the wound surface after the healing with wound surface bright and clean projection of a size.
Muscle regeneration factor of the present invention is expelled to tried on one's body the Mus, injection point has grown bright and clean cedductor in 3 days, and the cedductor that grows is dissected, and the muscular tissue at other position is just the same on one's body to be tried Mus.
On probation on human body as vulnerary, muscle regeneration factor is coated on the wound healing of energy accelerated in wounds, the position around the wound surface after the healing decrustation all protrudes.
With muscle regeneration factor, be injected into people's shank position, the result has also been swelled expected effect.When repeated trials, get rid of (or using separately) and take off the folds in a garment fusion agent, then all tests have no effect.Illustrate that taking off the fused agent of folds in a garment has superpower elimination rejection effect and promote two kinds of cells to take off the function that folds in a garment merges merging.
The present invention will be through behind the strict animal experiment and clinical trial, and available injection (one or many) is carried out augmentation rhinoplasty, grand chin, enlarged the bosom.It will become the optimal material of shaping and beauty surely, also will become the like to be beautiful brand of nature of the mankind, leave the face of human beautiful perpetual youth for.
Claims (4)
1, muscle regeneration factor of the present invention; be with animal newt cell; under the protection of taking off the folds in a garment fusion agent; take off folds in a garment with the experimental mouse cell and merge the histiocyte that merges protuberance; accept the newt cell once more and take off the histiocyte that the folds in a garment fusion grows protuberance; behind the amplification in vitro with take off the folds in a garment fusion agent, injection solvent, the muscle regeneration factor of the injection type of making.
2, muscle regeneration factor according to claim 1, in the plastic surgery, be used for augmentation rhinoplasty, grand chin, enlarge the bosom etc., the muscle regeneration factor one or many is injected into nose, chin, Ruzhong, just can grow and reach the protuberance tissue that beauty treatment designs.
3, muscle regeneration factor according to claim 1, in cosmetic surgery, with muscle regeneration factor, be injected in the tuck weave and the rift grain road floating, just can remove wrinkle, wrinkle originally will can not reproduce for a long time.
4, muscle regeneration factor according to claim 1, lack (recessed) that can be used for filling up any position of human body falls into, and repairs the position that needs protuberance (putting down).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200710122922XA CN101337089A (en) | 2007-07-04 | 2007-07-04 | Muscle regeneration factor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200710122922XA CN101337089A (en) | 2007-07-04 | 2007-07-04 | Muscle regeneration factor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101337089A true CN101337089A (en) | 2009-01-07 |
Family
ID=40211352
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA200710122922XA Pending CN101337089A (en) | 2007-07-04 | 2007-07-04 | Muscle regeneration factor |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101337089A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105246495A (en) * | 2013-01-09 | 2016-01-13 | Ise专业检测与咨询服务有限公司 | Decellularized biomaterial form non-mammalian tissue |
-
2007
- 2007-07-04 CN CNA200710122922XA patent/CN101337089A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105246495A (en) * | 2013-01-09 | 2016-01-13 | Ise专业检测与咨询服务有限公司 | Decellularized biomaterial form non-mammalian tissue |
| US10617790B2 (en) | 2013-01-09 | 2020-04-14 | Ise Professional Testing & Consulting Services, Inc. | Decellularized biomaterial from non-mammalian tissue |
| US11660376B2 (en) | 2013-01-09 | 2023-05-30 | NeXtGen Biologies, Inc. | Decellularized biomaterial from non-mammalian tissue |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Papel et al. | Facial plastic and reconstructive surgery | |
| Maas et al. | Implants in rhinoplasty | |
| US7799325B2 (en) | Removal of hypertrophic scars | |
| JP2003517858A (en) | Augmentation and repair of age-related soft tissue defects | |
| US20080152721A1 (en) | Augmentation and repair of spincter defects with cells including adipocytic cells | |
| CN106190967A (en) | A kind of autologous fat derived stem cell is for the preparation method of beautifying and antisenility | |
| JP2007521114A5 (en) | ||
| CN105435308A (en) | Breast implant three-dimensional structure and rapid forming method thereof | |
| Erdogan et al. | Augmentation rhinoplasty with dermal graft and review of the literature | |
| CN110787319A (en) | Implant for facial cosmetic lifting and application thereof | |
| Sajjad | Ocular prosthesis-a simulation of human anatomy: a literature review | |
| Jordan et al. | Evaluation and management of the anophthalmic socket and socket reconstruction | |
| Taub et al. | Prefabricated alloplastic implants for cranial defects | |
| CN101347638A (en) | Tissue-patching material for injection and preparation method thereof | |
| CN101337089A (en) | Muscle regeneration factor | |
| US20090074729A2 (en) | Augmentation and repair of spincter defects with cells including fibroblasts | |
| Li et al. | 3D printed gelatin-alginate bioactive scaffolds combined with mice bone marrow mesenchymal stem cells: A biocompatibility study | |
| CN107899074A (en) | Skin Cell spraying and preparation method thereof | |
| Owen et al. | Alloplastic reconstruction of the microtic ear | |
| Jiaman et al. | Modern Composite Materials and Technical Strategies in Posttraumatic Augmentation Rhinoplasty | |
| US20080118478A1 (en) | Hair undifferentiated cells | |
| EP3566726B1 (en) | Biomaterial inner condom, manufacturing method therefor, and application thereof | |
| Maillard et al. | Correction of depressed supratarsal sulcus by an arterial subcutaneous composite flap | |
| RU2373941C2 (en) | Method for correction of age-specific and pathological human skin changes | |
| Nikparto et al. | The current techniques in dorsal augmentation rhinoplasty: a comprehensive review |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20090107 |