CN101317808A - Packaging for sodium bicarbonate injection and preparation thereof - Google Patents
Packaging for sodium bicarbonate injection and preparation thereof Download PDFInfo
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- CN101317808A CN101317808A CNA2008101322613A CN200810132261A CN101317808A CN 101317808 A CN101317808 A CN 101317808A CN A2008101322613 A CNA2008101322613 A CN A2008101322613A CN 200810132261 A CN200810132261 A CN 200810132261A CN 101317808 A CN101317808 A CN 101317808A
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- sodium bicarbonate
- vessel
- packing
- bicarbonate injection
- gas
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Abstract
The invention discloses a package of sodium bicarbonate injection and a manufacturing method thereof. The package comprises a vessel (111, 41) that is made of gas barrier materials. The vessel contains the sodium bicarbonate injection (2) and is filled with carbon dioxide gas (3). The manufacturing method of the package is that the vessel is made of the gas barrier materials; the sodium bicarbonate injection (2) and the carbon dioxide gas (3) are loaded into the vessel; and a combination cover (12, 42) is hermetically connected with an interface or a bottle mouth. As the gas generated by drug liquid is sealed up in enclosed environment by a high gas barrier layer made of the gas barrier materials, and the drug liquid is in a relatively balanced state, thus ensuring the stability of the drug liquid. In addition, the plastic vessel is used for packaging of the liquid substances that can produce gas substances, such as the sodium bicarbonate injection, and the like, thus facilitating manufacturing, processing, transportation and storage.
Description
Technical field
The present invention relates to the medical packaging field, be specifically related to a kind of packing and manufacture method thereof that is used for sodium bicarbonate injection.
Background technology
At present, in the medical packaging field, plastics package has obtained to use widely with its good stable, cheap cost.
But some liquid medicine but can only adopt glass bottle packaging, and this is because vial has high gas barrier properties.With sodium bicarbonate injection commonly used is example, because sodium bicarbonate injection easily resolves into sodium carbonate, carbon dioxide and water in storage process, as this thing happens, then the pH value of sodium bicarbonate injection changes, as is expelled to the pH value disorder that then can cause human body fluid in the human body.The equation that sodium bicarbonate aqueous solution decomposes is:
By following formula as can be known, it is reversible process that sodium bicarbonate aqueous solution decomposes, as long as the carbon dioxide that decomposes does not run off, then the sodium bicarbonate of Fen Xieing can restore again.Because vial has high gas barrier properties, as long as certain carbon dioxide is arranged in bottle, then sodium bicarbonate just can not decompose.
If pack sodium bicarbonate injection with plastic bottle (bag), because the existing used plastic material of plastic bag (being mainly polypropylene) gas barrier properties is not fine (especially when high temperature sterilize), so the carbon dioxide gas that sodium bicarbonate aqueous solution decomposes is out known from experience to the bag exosmosis, after the flow of carbon dioxide gas in the bottle (bag) is lost, then the sodium bicarbonate aqueous solution in the bottle (bag) will decompose, thereby causes the pH value of sodium bicarbonate injection to change.
Therefore, can only use vial at present, and can not be used as packing material with packaged with plastic container such as the such liquid substance of sodium bicarbonate injection.
Summary of the invention
The present invention is devoted to overcome the above-mentioned defective of prior art just and makes.Technical problem to be solved by this invention is to provide a kind of packing and manufacture method thereof that is used for sodium bicarbonate injection.
Another technical problem to be solved by this invention is, a kind of packing that is used for liquid substance is provided, and it is used to hold the liquid substance that can produce gaseous matter.
According to an aspect of the present invention, the invention provides a kind of packing that is used for sodium bicarbonate injection, this packing comprises vessel, and this vessel is made by gas-barrier material, wherein accommodates sodium bicarbonate injection, and is filled with carbon dioxide.
Preferably, this vessel comprises: the internal layer of being made by polypropylene PP or polythene PE plastics; Intermediate layer and skin, wherein, the one deck at least in intermediate layer and the skin is made by gas-barrier material.
Preferably, gas-barrier material is high-barrier EVOH or silicon oxide or titania meterial.
Preferably, this packing that is used for sodium bicarbonate injection further comprises: interface, and this interface and vessel are tightly connected, and communicate with the cavity of vessel inside; And composite cover, it is sealedly connected on the interface.
Preferably, plastic containers are plastic bag packaging or are plastic bottle packing.
According to a further aspect in the invention, also provide a kind of manufacture method that is used for the packing of sodium bicarbonate injection, this method comprises: the vessel that is used for the packing of sodium bicarbonate injection by the gas-barrier material manufacturing; Vessel is connected with sealing joint; Sodium bicarbonate injection and carbon dioxide are packed in the vessel; And composite cover is sealedly attached to interface.
Preferably, this method also comprises described sterilization of plastic containers and/or lamp inspection.
According to another aspect of the invention, provide a kind of packing that is used for liquid substance, this liquid substance can produce gaseous matter, this packing that is used for liquid substance comprises vessel, vessel is made by gas-barrier material, is used to accommodate the aforesaid liquid material, and is filled with the above-mentioned gas material.
The present invention has following beneficial effect:
1. gas-barrier material is made high gas barrier layer the gas that medicinal liquid produces is enclosed in the closed environment, makes medicinal liquid can be in the state of a relative equilibrium, has guaranteed the stability of medicinal liquid.
2. pack the packing of liquid substance that can produce gaseous matter such as sodium bicarbonate injection etc. with plastic containers, be convenient to production, processing and accumulating.
Should be appreciated that above generality is described and the following detailed description is all enumerated and illustrative, purpose is for to the claimed further instruction that the invention provides.
Description of drawings
For understanding the present invention better, show embodiments of the invention by accompanying drawing.These accompanying drawings are used for explaining principle of the present invention with description.Among the figure:
Fig. 1 is embodiment one a plastic bag packaging structural representation;
Fig. 2 is embodiment two plastic bottle packing structural representations;
Fig. 3 is the detailed structure enlarged diagram of plastic containers body.
Each label is represented among the figure:
1, plastic bag packaging 11, plastic bag 111, plastic bag container body
112, interface 12, composite cover
2, sodium bicarbonate injection;
3, carbon dioxide;
4, plastic bottle packing 41, plastic bottle vessel
411, bottleneck 42, composite cover
The specific embodiment
Below in conjunction with accompanying drawing embodiments of the invention are elaborated, but the multitude of different ways that the present invention can be defined by the claims and cover is implemented.
Embodiment one
As shown in Figure 1, it is the plastic bag packaging 1 that is used to pack sodium bicarbonate injection according to an embodiment of the invention, this plastic bag packaging 1 comprises plastic bag 11 and composite cover 12, described plastic bag 11 is made up of the interface 112 of vessel 111 and welding with it, described interface 112 connects with the cavity of described vessel inside, and described composite cover 12 is sealedly connected on the described interface 112.Composite cover is an assembly commonly used in the liquid substance plastics package, for example the applicant's Chinese patent is 03048898.X number, No. 200420036225.4, No. 200520052561.2, composite cover disclosed in No. 200710149802.9, these existing composite covers all can be used among the present invention.Plastic bag packaging 1 accommodates sodium bicarbonate injection 2, and is filled with carbon dioxide 3.As shown in Figure 3, plastic bag container body 111 is that the internal layer of plastic foil is PP (polypropylene) or PE (polyethylene) material, and the intermediate layer is high-barrier EVOH or silicon oxide or titania meterial, and skin is PP or PET materials such as (polyethylene terephthalate).The intermediate layer that high gas-barrier material is made guarantees that carbon dioxide 3 can be to the bag exosmosis.
At first make as shown in Figure 3 plastic bag container body 111 with compound or the arch mode of squeezing, that is, and plastic foil.With 112 welding of plastic bag container body 111 and interface or bondingly become plastic bag 11, sodium bicarbonate injection and carbon dioxide are poured in the plastic bag 11, and interface 112 is welded or adhering and sealing one-tenth plastic bag packaging as shown in Figure 1 with composite cover 12.With it sterilization back and lamp inspection, thereby make spendable sodium bicarbonate injection plastic bag packaging.
Embodiment two
As shown in Figure 2, plastic bottle packing 4 comprises vessel 41 and the composite cover 42 that has bottleneck 411, and described composite cover 42 is sealedly connected on the bottleneck 411 of described vessel.Plastic bottle packing 4 accommodates sodium bicarbonate injection 2, and is filled with carbon dioxide 3.As shown in Figure 3, plastic bottle vessel 41 is that the internal layer of plastic bottle is PP or PE material, and the intermediate layer is high-barrier EVOH or silicon oxide or titania meterial, and skin is materials such as PP or PET.The intermediate layer that high gas-barrier material is made guarantees that carbon dioxide 3 can be to the bottle exosmosis.
At first make structural pipe wall pipe as shown in Figure 3, blow out plastic bottle vessel 41 as shown in Figure 2 again, i.e. plastic bottle with compound or the arch mode of squeezing.Sodium bicarbonate injection and carbon dioxide are poured in the plastic bottle vessel 41, and bottleneck 411 welding or adhering and sealing are become as shown in Figure 2 with composite cover 42.With it sterilization back and lamp inspection, thereby make spendable sodium bicarbonate injection plastic bag packaging.
Although the present invention is illustrated with reference to accompanying drawing and preferred embodiment, obviously, for a person skilled in the art, under the prerequisite that does not deviate from the spirit and scope of the present invention, can make various changes and variation to the present invention.Various change of the present invention, the content that changes by appending claims and equivalent thereof contain.
Claims (10)
1. packing that is used for sodium bicarbonate injection, the described packing that is used for sodium bicarbonate injection comprises vessel (111,41), described vessel (111,41) make by gas-barrier material, wherein accommodate sodium bicarbonate injection (2), and be filled with carbon dioxide (3).
2. the packing that is used for sodium bicarbonate injection according to claim 1 is characterized in that, described vessel (111,41) comprising: the internal layer of being made by polypropylene PP or polythene PE plastics (5); Intermediate layer (6); And outer (7), wherein, described intermediate layer (6) are made by gas-barrier material with the one deck at least in the described skin (7).
3. the packing that is used for sodium bicarbonate injection according to claim 2 is characterized in that, described gas-barrier material is high-barrier EVOH or silicon oxide or titania meterial.
4. the packing that is used for sodium bicarbonate injection according to claim 1, it is characterized in that, described plastic containers are plastic bag packaging (1), described plastic bag packaging comprises: interface (112), described interface (112) is tightly connected with described vessel (111), and communicates with the cavity of described vessel (111) inside; And composite cover (12), it is sealedly connected on the described interface (112).
5. the packing that is used for sodium bicarbonate injection according to claim 1, it is characterized in that, described plastic containers are for being plastic bottle packing (4), described plastic bottle packing comprises vessel (41) and composite cover (42), and described composite cover (42) is sealedly connected on the bottleneck (411) of described vessel.
6. a manufacture method that is used for the packing of sodium bicarbonate injection is characterized in that, described method comprises:
Make the vessel (111,41) of described packing by gas-barrier material;
Sodium bicarbonate injection (2) and carbon dioxide (3) are packed in the described vessel (111,41); And
Composite cover (12,42) is sealedly attached to described interface (112) or bottleneck (411).
7. according to the described method of claim 6, it is characterized in that, also comprise described sterilization of plastic containers and/or lamp inspection.
8. method according to claim 6 is characterized in that, described vessel (111,41) comprising: the internal layer of being made by polypropylene PP or polythene PE plastics (5);
Intermediate layer (6); And outer (7), wherein, described intermediate layer (6) are made by gas-barrier material with the one deck at least in the described skin (7).
9. method according to claim 8 is characterized in that, described gas-barrier material is high-barrier EVOH or silicon oxide or titania meterial.
10. packing that is used for liquid substance, described liquid substance can produce gaseous matter, it is characterized in that, the described packing packing container that is used for liquid substance comprises vessel (111,41), described vessel (111,41) is made by gas-barrier material, be used to accommodate described liquid substance, and be filled with described gaseous matter.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101322613A CN101317808B (en) | 2008-07-22 | 2008-07-22 | Packaging for sodium bicarbonate injection and preparation thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101322613A CN101317808B (en) | 2008-07-22 | 2008-07-22 | Packaging for sodium bicarbonate injection and preparation thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101317808A true CN101317808A (en) | 2008-12-10 |
| CN101317808B CN101317808B (en) | 2011-09-14 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008101322613A Active CN101317808B (en) | 2008-07-22 | 2008-07-22 | Packaging for sodium bicarbonate injection and preparation thereof |
Country Status (1)
| Country | Link |
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| CN (1) | CN101317808B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104107140A (en) * | 2014-06-23 | 2014-10-22 | 武汉药谷生物工程有限公司 | Flexible package for injections including sodium bicarbonate |
| US11925703B1 (en) | 2022-07-29 | 2024-03-12 | Xellia Pharmaceuticals Aps | Liquid composition comprising glucose |
-
2008
- 2008-07-22 CN CN2008101322613A patent/CN101317808B/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104107140A (en) * | 2014-06-23 | 2014-10-22 | 武汉药谷生物工程有限公司 | Flexible package for injections including sodium bicarbonate |
| US11925703B1 (en) | 2022-07-29 | 2024-03-12 | Xellia Pharmaceuticals Aps | Liquid composition comprising glucose |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101317808B (en) | 2011-09-14 |
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