CN101292859B - Retina cell microscopic imaging system capable of executing demixing scan - Google Patents
Retina cell microscopic imaging system capable of executing demixing scan Download PDFInfo
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- CN101292859B CN101292859B CN2007100217761A CN200710021776A CN101292859B CN 101292859 B CN101292859 B CN 101292859B CN 2007100217761 A CN2007100217761 A CN 2007100217761A CN 200710021776 A CN200710021776 A CN 200710021776A CN 101292859 B CN101292859 B CN 101292859B
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Abstract
The present invention discloses a retina cell microscopic imaging system which can conduct stratified scanning and comprises an illuminating system and a microscopic imaging optical unit. The inside of an optical path between the illuminating system and a human eye (601) is provided with a stratified scanning optical unit which comprises a first object lens (501) and a second object lens (502). The first object lens (501) and/or the second object lens (502) can move critically along the axial direction. The parallel incident illumination beams of the illuminating system are focused on certain film inside a human eye retina (603) through the second object lens (502) and the first object lens (501) sequentially. During the stratified scanning, a focusing face formed on the retina (603) moves correspondingly at each cell layer inside the retina (603) along with the movement of the first object lens (501) and the second object lens (502). A small depth of focus imaging optical unit is used as the microscopic imaging optical unit. The retina cell microscopic imaging system of the present invention has simple structure and can effectively conduct stratified observation towards each film forming the retina.
Description
Technical field
The present invention relates to a kind of retina cell microscopic imaging system, especially relate to a kind of retina cell microscopic imaging system that carries out demixing scan.
Background technology
In the existing retina cell microscopic imaging system, also do not relate to amphiblestroid demixing scan.For example: the retina cell microscopic imaging system of describing among the patent CN99115051.1 of Photoelectric Technology Inst., Chinese Academy of Sciences, CN99115052.X, CN99115053.8 and the CN99115054.6.
Because retina is a kind of phase-type, transparent organizational structure; Gross thickness is only at the hundreds of micron; Multiple structure is distributing in such thickness range; The every layer of different cells tissue that distributing, the distribution of various cells and situation of change thereof and disease and situation of change thereof are closely related, so people hope and can carry out the layering observation to forming amphiblestroid each rete.In fact, go up the spatial distribution of cell if can know each layer clinically, will be extremely beneficial to the accurate judgement of optical fundus situation.For this reason; If retina cell microscopic imaging system can not separate into picture; Each confluent monolayer cells is with being imaged on simultaneously on the imaging surface; It is quite difficult on this image, how distinguishing each confluent monolayer cells realizingly, so retina cell microscopic imaging system can not separate into as will seriously restricting its effect.For this reason, the present invention proposes a kind of demixing scan formation method, help retina cell microscopic imaging system that retina is carried out the demixing scan imaging.
Summary of the invention
The objective of the invention is: a kind of retina cell microscopic imaging system that carries out demixing scan is provided, and it is simple in structure, can effectively carry out the layering observation to forming amphiblestroid each rete.
Technical scheme of the present invention is: a kind of retina cell microscopic imaging system that carries out demixing scan; It includes illuminator, micro-imaging optical unit; In the light path between the said illuminator the pure man eye pupil hole; Be provided with the demixing scan optical unit, said demixing scan optical unit comprises first object lens and second object lens, and said first object lens and/or second object lens can in axial direction accurately move; The parallel incident illuminating bundle of illuminator is successively through focusing on behind second object lens and first object lens on certain rete in the human eye retina; When demixing scan; Along with moving of first object lens and/or second object lens, make corresponding mobile at the focusing surface that forms on the retina each cellular layer in retina.
Further explain in the face of technique scheme down:
1. said micro-imaging optical unit comprises in order to the eyeglass head that tentatively forms images with in order to the picture with the eyeglass head and projects the imaging lens on the final imaging surface.
2. said imaging lens is little depth field imaging camera lens.
Advantage of the present invention is:
1. the retina cell microscopic imaging system that carries out demixing scan of the present invention can effectively carry out the layering observation to forming amphiblestroid each rete.
2. the retina cell microscopic imaging system that carries out demixing scan of the present invention, simple in structure, effect is obvious.
Description of drawings
Below in conjunction with accompanying drawing and embodiment the present invention is done further description:
Fig. 1 is a structural representation of the present invention.
Wherein: 101 illuminators; 102 light sources; 103 heat shields; 104 neutral density sheets; 110 collecting objectives; 111 graticles; 112 projection objectives; 113 bandpass filters; 201 laser beacons; 202 collimator objectives; 300 total reflective mirrors; 401 first polarization beam splitter prism PBS; 402 second polarization beam splitter prism PBS; 501 first object lens; 502 second object lens; 601 human eyes; 603 retinas; 700 first apertures coupling lens group; 701 apertures coupling camera lens; 702 apertures coupling camera lens; 8001/4 wave plate; 900 wave-front correctors; 1,000 second apertures coupling lens group; 1001 apertures coupling camera lens; 1002 apertures coupling camera lens; 1100 half-reflecting half mirrors; 1200 Wavefront sensors; 1301 half-reflecting half mirrors; 1302 completely reflecting mirrors; 1303 half-reflecting half mirrors; 1304 completely reflecting mirrors; 1305 compensating plates; 1306 wedge groups; 1401 eyeglass heads; 1402 little depth field imaging camera lenses; 1500 imaging surfaces.
The specific embodiment
Embodiment: as shown in Figure 1, a kind of retina cell microscopic imaging system that carries out demixing scan, it includes parts such as illuminator, demixing scan optical unit, micro-imaging optical unit.
Through after the reflection of the first polarization beam splitter prism PBS401, get into the demixing scan optical unit from the parallel incident beam of illuminator (as shown in Figure 1, as to form to bandpass filter 113), focus on through people's refraction of eye body then by reflecting mirror 101.
The demixing scan optical unit comprises first object lens 501 and second object lens 502.Wherein, first object lens 501 and/or second object lens 502 can move as Precise Distance.In the present embodiment, choose that first object lens 501 are arranged to fix, second object lens 502 can in axial direction accurately move.
This demixing scan optical unit not only can carry out diopter to human eye and regulate but also can carry out demixing scan to retina.
The micro-imaging optical unit comprises in order to the eyeglass head 1401 that tentatively forms images with in order to the picture with eyeglass head 1401 and projects the little depth field imaging camera lens 1402 on the final imaging surface 1500.
Above-mentioned, the illuminating bundle that incides the demixing scan optical unit is a directional light, and the light beam that turns back to outgoing behind the demixing scan optical unit also is directional light.The light beam that incides eyeglass head 1401 is a directional light.
When retina 603 is observed; At first the 502 pairs of human eyes of second object lens through the demixing scan optical unit carry out the diopter adjusting; Make people's refraction of eye body to the clear focusing of parallel incident beam, on the micro-imaging optical unit final imaging surface 1500 of (forming), can see the image of retina 603 this moment by eyeglass head 1401 and imaging lens 1402 from light-source system.
When retina 603 being carried out demixing scan observation or imaging; Accurate second object lens 502 that move in the demixing scan optical unit in front and back; The focusing surface that formed by people's refraction of eye body illumination beam this moment also synchronously moves forward and backward in retina 603; After turning back to the demixing scan optical unit, a light beam that is reflected by light beam focal plane place layer forms collimated light beam; Incide eyeglass head 1401 back forms retina layer on its focal plane preliminary image, on its final imaging surface 1500, form the image of retina 603 these layers again through imaging lens 1402 backs.Because the imaging lens 1402 imaging depth of field are little, so other rete of retina can not blur-free imaging.
Certainly, the retina cell microscopic imaging system that carries out demixing scan of the present invention also can have multiple conversion and remodeling, is not limited to the concrete structure of above-mentioned embodiment.In a word, protection scope of the present invention should comprise those conspicuous to those skilled in the art conversion or substitute and remodeling.
Claims (1)
1. retina cell microscopic imaging system that can carry out demixing scan; It includes illuminator, micro-imaging optical unit; It is characterized in that: in the light path between said illuminator to the human eye (601); Be provided with the demixing scan optical unit, said demixing scan optical unit comprises first object lens (501) and second object lens (502), and said first object lens (501) and/or second object lens (502) can in axial direction accurately move; The parallel incident illuminating bundle of illuminator is successively through focusing on behind second object lens (502) and first object lens (501) on certain rete in the human eye retina (603); When demixing scan; Along with moving of first object lens (501) and/or second object lens (502), go up focusing surface each cellular layer in retina (603) that forms at retina (603) and make corresponding mobile; Said micro-imaging optical unit comprises in order to the eyeglass head (1401) that tentatively forms images with in order to the picture with eyeglass head (1401) and projects the imaging lens (1402) on the final imaging surface (1500); Said imaging lens (1402) is little depth field imaging camera lens.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN2007100217761A CN101292859B (en) | 2007-04-25 | 2007-04-25 | Retina cell microscopic imaging system capable of executing demixing scan |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2007100217761A CN101292859B (en) | 2007-04-25 | 2007-04-25 | Retina cell microscopic imaging system capable of executing demixing scan |
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| CN101292859A CN101292859A (en) | 2008-10-29 |
| CN101292859B true CN101292859B (en) | 2012-07-04 |
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| CN102028449B (en) * | 2010-08-16 | 2012-12-12 | 苏州六六视觉科技股份有限公司 | Human eye retina imaging system and method capable of carrying out layered imaging |
| CN107126189B (en) * | 2016-05-31 | 2019-11-22 | 瑞尔明康（杭州）医疗科技有限公司 | Optical module and retina image-forming equipment for retina image-forming |
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