CN101283935B - Blockage capable of reducing the thrombus source - Google Patents
Blockage capable of reducing the thrombus source Download PDFInfo
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- CN101283935B CN101283935B CN2007100738699A CN200710073869A CN101283935B CN 101283935 B CN101283935 B CN 101283935B CN 2007100738699 A CN2007100738699 A CN 2007100738699A CN 200710073869 A CN200710073869 A CN 200710073869A CN 101283935 B CN101283935 B CN 101283935B
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Abstract
The invention relates to an invasive medical device, in particular to a stopper for treating the congenital heart disease. A stopper capable of reducing thrombus source is composed of a net made of a medically implantable material, wherein the net has an open and hollow left disk Compared with prior art, the stopper has reduced weight since the disk is partially or completely open and hollow, thus reducing the burden implanted into the human body. Moreover, the stopper in prior art is mainly made of metal, but the stopper in the invention can greatly reduce the coverage rate of metal and lowers the leakage amount of metal ions, thus effectively suppressing the generation of thrombus. Tests show that the stopper can effectively promote coverage of endothelial cells, so that a natural isolation layer can be formed on the surface in a short time, thus greatly improving the blockage effect.
Description
Technical field
The present invention relates to a kind of interventional medical device, particularly a kind of stopper that is used to treat congenital heart disease.
Background technology
Congenital heart disease (abbreviation congenital heart disease) is a fetal period cardiovascular abnormal development and the congenital malformation that forms is the modal heart disease of children's.The sickness rate of congenital heart disease is about birth life birth baby's 7～8 ‰, and untreated person about 34% can be dead in 1 month, and 50% is dead in 1 years old, gives birth to the early stage dead person in back and is mostly complex deformity or the heavier person of the state of an illness.Maximum in all kinds of congenital heart diseases with ventricular septal defect, secondly be patent ductus arteriosus, fallot's disease and atrial septal defect.
In recent years; Because the application of cardiac catheterization and cardioangiography; And the development of cardiac operation under direct vision under the extracorporeal circulation; Make clinically the situation that congenital heart disease is difficult for diagnosis and lacks the treatment way that very big variation has taken place, popularizing of especially emerging interventional therapeutic technique more makes the diagnosis and treatment of congenital heart disease that very big change has been arranged.Interventional therapeutic technique is to develop a kind of rapidly clinical treatment technology in the last few years, and it has, and wound is little, safety, good effect, easy and simple to handle, advantage such as the hospital stays is short, patients ' recovery is fast.Along with updating of interventional medical device, the indication of its treatment also will constantly enlarge, because this technology has simple and direct safety, effect and reliable curative advantage, believing in this century to have more wide application prospect.
The interventional therapy medical apparatus and instruments of existing congenital heart disease mainly contains following several types: atrial septal defect plugging device, ventricular septal defect, patend ductus arteriosus occluder.This type interventional medical device clinically obtained good application, its danger that massive blood loss brings of can avoiding performing the operation, and the crowd who is suitable for is also increasing.
Although congenital heart disease is got involved medical product and obtained the prominent development that flies to jump suddenly, still exist weak point to await further solution.Existing stopper adopts more titanium-nickel wire braiding to form; Tenor is higher; Prior art stopper shown in figure 11, its tinsel cover fully whole about two cards, in addition; The tinsel intersection of two cards adopts end socket and bolt head to fix, and has increased undoubtedly to contact the back for a long time with blood behind the tenor implant into body and be prone to concurrent inflammation and formation thrombosis.Especially left atrium after implanting atrial septal defect plugging device, causes the coarse of atrial walls, is prone to the hyperamization bolt and forms.In case the bolt head comes off along with blood flows into other internal organs of health, can cause serious consequence, like apoplexy.Application number be 200410053861.2 document announced a kind of patend ductus arteriosus occluder, atrial septal defect plugging device and ventricular septal defect that is used for congenital heart disease former card through the metal wire knitted technology; Form smooth plane; Planar center is that the annular inflection ring of support establishment silk makes its connection in aggregates, does not have riveted joint on the surface of support.Although above-mentioned stopper does not adopt end socket and bolt head to rivet; But since tinsel cover fully whole about two cards; Its tenor is still very high; Influence climbing of endotheliocyte and covered, thereby will form the natural sealing coat of one deck on its surface in a long time, be unfavorable for the stifled effect of closing.
Summary of the invention
Technical problem to be solved by this invention is, overcomes the deficiency of prior art, and a kind of stopper of new structure is provided, and can reduce tenor, reduces thrombosis, but also can improve the stifled effect of closing.
Of the present inventionly realize through following following technical scheme: a kind of stopper that reduces thrombus source, but the net of processing by the medical science embedded material at a distance from forming, the separated left room of said net umbrella cover is open hollow.
The complete open hollow of the whole formation of left umbrella cover that said net is separated, perhaps left umbrella cover partly forms open hollow.
Said net inwardly turns at a distance from the umbrella limit.
Be built-in with the choked flow film at said net at a distance from structure, said choked flow film forms enclosed construction.
Said choked flow film is close to net at a distance from structure.
Said net can be provided with a connecting device that links to each other with carrier on right room umbrella.
Said connecting device is a screw device.
Said right room umbrella cover is that a net connects and composes through seal wire and umbrella room body at a distance from dish, and the said connecting device that links to each other with carrier is loaded on net on dish, when discharging stopper, at first unclamps seal wire one end, and seal wire is removed, and will reclaim at a distance from dish with the net of connecting device then.
The present invention compared with prior art because the room umbrella cover is the open or complete open hollow of part, has reduced the weight of stopper, has alleviated human body and has inserted burden partly; And mostly stopper is that metal processes in the prior art, and the present invention can significantly reduce the coverage rate of metal, has reduced the leakage of metal ion, thereby can effectively avoid the formation of thrombosis.Through experiment showed, that the present invention can effectively promote climbing of endotheliocyte to cover, but thereby form the natural sealing coat of one deck on its surface within a short period of time, improved the stifled effect of closing greatly.
Description of drawings
Fig. 1 looks end view drawing for the structural representation and the right side of a kind of ASD stopper of the present invention;
Fig. 2 looks end view drawing for the another kind of structural representation and the right side of ASD stopper provided by the invention;
Fig. 3 looks end view drawing for the third structural representation and the left side of ASD stopper provided by the invention;
Fig. 4 looks end view drawing for the 4th kind of structural representation and the left side of ASD stopper provided by the invention;
Fig. 5 is the partial enlarged drawing of A part shown in Figure 4;
Fig. 6 is Fig. 4, the separated dish of net shown in 5 sketch map;
Fig. 7 removes the sketch map of net behind dish for Fig. 4;
Fig. 8 looks end view drawing for the 5th kind of structural representation and the left side of the ASD stopper that provides of invention;
Fig. 9 is the structural representation of VSD stopper provided by the invention;
Figure 10 is the structural representation of PDA stopper provided by the invention;
Figure 11 is the structural representation of existing ASD stopper
The specific embodiment
Below in conjunction with specific embodiment the present invention is done further explain: the stopper among the present invention is applicable to atrial septal defect (ASD) stopper, patent ductus arteriosus (PDA) stopper and ventricular septal defect (VSD) stopper etc. of congenital heart disease therapeutic process.
As shown in Figure 1, but the net of stopper constitute at a distance from being compiled into fine and closely woven net by the medical science embedded material, left room umbrella 3 umbrella covers are open hollow.
Like Fig. 2, shown in 3, be that example is explained with atrial septal defect (ASD) stopper.The wire netting that this stopper is mainly formed by NiTi alloy silk braiding at a distance from 1 be arranged on the separated intermediary choked flow film 2 of wire netting and form, choked flow film 2 can be PET, PTFE or degradable collagen-based materials.Whole stopper is divided into left room umbrella 3, right room umbrella 4 and 5 three parts of waist, and nerve of a covering is not separated fully for wherein left room umbrella cover 3.As shown in Figure 2, the present invention partly forms open hollow at net at a distance from 1 left room 3 umbrella covers, and left room 3 umbrella covers form sealing by choked flow film 2; As shown in Figure 3, at a distance from 1 the complete open hollow of the left room whole formation of 3 umbrella covers, left room 3 umbrella covers form sealing by choked flow film 2 at net in the present invention.Can find out from Fig. 2,3, Obstruct membrane 2 and net sewed up at a distance from 1, let tightly card of Obstruct membrane 2 and room umbrella cover, further reduce Obstruct membrane 2 and room umbrella cover net, make this part help climbing of endotheliocyte more and cover at a distance from 1 gap with stitching thread 8.On the right room of the stopper umbrella 4 connecting device that links to each other with carrier 6 is set, this device is screw device.
When implanting Fig. 2, stopper shown in 3, link to each other with carrier through screw device 6, under the X-ray surveillance equipment, stopper is delivered to lesion locations then by carrier, adjust angle after, the release stopper is with the shutoff defect.
Like Fig. 4,5, shown in 6; To be a net at a distance from dish 9 be connected through seal wire 7 the right room of stopper umbrella cover on right umbrella room body, constitutes; The screw connection 6 that links to each other with carrier is loaded on net on dish 9, in the time of should discharging stopper, at first unclamps seal wire 7 one ends; Seal wire 7 is removed, and the net with threaded device 6 reclaims at a distance from dish 9 then.Said screw device 6 can also sleeve threads, and are connected with the outer sticking tube female thread of carrier.It is as shown in Figure 7 at a distance from the stopper of dish 9 to remove net.
When implanting stopper shown in Figure 4, link to each other with carrier through screw device 6, under the X-ray surveillance equipment, stopper is delivered to lesion locations then by carrier, adjust angle after, the release stopper is with the shutoff defect.When confirming to discharge stopper, at first unclamp seal wire 7 one ends, seal wire 7 is removed, the net with threaded device 6 reclaims at a distance from dish 9 then.
As shown in Figure 8, ASD stopper of the present invention can also inwardly turn over 11 at a distance from 1 umbrella limit with net.
Respectively the structural representation of VSD stopper and PDA stopper among the present invention among Fig. 9, Figure 10.
Above-mentioned stopper cross sectional shape can be according to the sick body concrete condition and fixed polygon.
Experiment shows, the stopper among the present invention can effectively promote and the combining of cell, and the speed of covering of climbing of endothelium is wanted far the stopper faster than prior art.Thereby stopper of the present invention can be expected to form the natural sealing coat of one deck on its surface within a short period of time, not only improved stifledly to close effect, and improved the biocompatibility of stopper greatly.
Claims (9)
1. stopper that can reduce thrombus source, but the net of processing by the medical science embedded material at a distance from forming, it is characterized in that: said net is open hollow at a distance from left room umbrella cover, said net is a bilayer at a distance from the edge of left room umbrella cover.
2. the stopper that reduces thrombus source according to claim 1 is characterized in that: said net is at a distance from the complete open hollow of the whole formation of left room umbrella cover, and perhaps left umbrella cover partly forms open hollow.
3. the stopper that reduces thrombus source according to claim 1 is characterized in that: said net inwardly turns at a distance from umbrella cover limit, left room.
4. according to claim 1,2, the 3 described stoppers that reduce thrombus source, it is characterized in that: be built-in with the choked flow film at said net at a distance from structure, said choked flow film forms enclosed construction.
5. the stopper that reduces thrombus source according to claim 4 is characterized in that: said choked flow film is close to net at a distance from structure.
6. the stopper that reduces thrombus source according to claim 5 is characterized in that: said net can be provided with a connecting device that links to each other with carrier on right room umbrella.
7. the stopper that reduces thrombus source according to claim 6 is characterized in that: said connecting device is a screw device.
8. the stopper that reduces thrombus source according to claim 6; It is characterized in that: said right room umbrella cover is that a net connects and composes through seal wire and umbrella room body at a distance from dish; The said connecting device that links to each other with carrier is loaded on net on dish, when discharging stopper, at first unclamps seal wire one end; Seal wire is removed, will reclaim at a distance from dish with the net of connecting device then.
9. the stopper that reduces thrombus source according to claim 7; It is characterized in that: said right room umbrella cover is connected and composed through seal wire and umbrella room at a distance from dish by a net; The said connecting device that links to each other with carrier is loaded on net on dish, when discharging stopper, at first unclamps seal wire one end; Seal wire is removed, will reclaim at a distance from dish with the net of connecting device then.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100738699A CN101283935B (en) | 2007-04-12 | 2007-04-12 | Blockage capable of reducing the thrombus source |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100738699A CN101283935B (en) | 2007-04-12 | 2007-04-12 | Blockage capable of reducing the thrombus source |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101283935A CN101283935A (en) | 2008-10-15 |
| CN101283935B true CN101283935B (en) | 2012-05-23 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007100738699A Active CN101283935B (en) | 2007-04-12 | 2007-04-12 | Blockage capable of reducing the thrombus source |
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| CN (1) | CN101283935B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103110444A (en) * | 2013-01-22 | 2013-05-22 | 陈平根 | Biodegradable fabric body capable of being developed and conveying device |
| US11911258B2 (en) * | 2013-06-26 | 2024-02-27 | W. L. Gore & Associates, Inc. | Space filling devices |
| CN104116574A (en) * | 2014-07-04 | 2014-10-29 | 先健科技(深圳)有限公司 | Plug and plugging device |
| CN104720854B (en) * | 2015-02-25 | 2017-04-26 | 上海形状记忆合金材料有限公司 | Sectioned degradable plugging device |
| CN106510788A (en) * | 2016-12-12 | 2017-03-22 | 上海心玮医疗科技有限公司 | Left atrial appendage occlusion device |
| CN108261214B (en) | 2016-12-31 | 2020-06-12 | 先健科技(深圳)有限公司 | Occluder and method for suturing occluder |
| CN108969033A (en) * | 2018-07-25 | 2018-12-11 | 汪建军 | A kind of preventing thrombosis plugging device |
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2007
- 2007-04-12 CN CN2007100738699A patent/CN101283935B/en active Active
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| CN101283935A (en) | 2008-10-15 |
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