CN101279083B - Chinese medicine preparation for curing acute or chronic cholecystitis and method of preparing the same - Google Patents
Chinese medicine preparation for curing acute or chronic cholecystitis and method of preparing the same Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine preparation for curing acute and chronic cholecystitis and is characterized in that the traditional Chinese medicine preparation comprises pure traditional Chinese medicines, such as bupleurum chinense, fruit of immature citron, gardenia, oriental wormwood, white peony root, angelica, hemlock parsley, pawpaw, dried ginger, Chinese goldthread, fleshfingered citron, cassia twig, licorice, etc., and the prescription is formed by scientific compatibility. The formula is unique and reasonable, having the function of removing heat from the liver and benefitting the gallbladder, dissipating stagnant qi, regulating the flow of qi and relieving pain and giving special attention to detoxication and anti-inflammatory effect and more to the synergistic action of the formation of the prescription. The invention overcomes the technical bias that gives priority to gallbladder benefitting and takes detoxication and anti-inflammatory effect as auxiliary, and provides a traditional Chinese medicine preparation for curing acute and chronic cholecystitis which combines gallbladder benefitting and detoxication and anti-inflammatory effect, while attaches more importance to detoxication and anti-inflammatory effect, thereby treating both the symptoms and root causes, combining health nursing and diseases curing and having the advantages of short course of treatment, prominent and fast curative effect, good pain relieving effect and exemption from toxicity and side effect, etc. The preparation method of the invention is scientific and reasonable, with short process, and the effective constituents of the traditional Chinese medicine preparation are all retained without any loss during the preparation process.
Description
Technical field
The present invention relates to the field of Chinese medicines, is a kind of Chinese medicine preparation for the treatment of acute and chronic cholecystitis and preparation method thereof.
Background technology
Acute and chronic cholecystitis system is by biliary tract, gallbladder disorder, the hydrocholecystis due to the bacteria attack, and cell is invaded profit, can cause the blood supply obstacle of gallbladder wall again, and end form becomes cholecystitis.Acute cholecystitis is failed thoroughly to be cured and is formed chronic cholecystitis.Theory of Chinese medical science think acute and chronic cholecystitis be dampness-heat in the liver and gallbladder, qi stagnation blood stasis, transverse invasion of hyperactive liver-QI etc. because of due to.Be frequently-occurring disease, commonly encountered diseases.Existing treatment acute and chronic cholecystitis adopts antibiotic, anti-inflammatory and choleretic expectant treatment more, and medicine can be divided into two big classes, and the one, bile is discharged promoter; The 2nd, promote the biliary function of gallbladder promoting medicine of hepatic secretion.For example: armillarisin A, armillarisin A can promote bile secretion, makes bile thinning, output, increase, and loose oddi's sphincter promotes gall bladder bile to discharge, remarkable cholagogue and eliminating inflammation, spasmolysis and analgesia effect are arranged, but clinical practice causes serious harm to patient's hepatic and renal function; Dehydrocholic acid, dehydrocholic acid have the effect of obvious increase bile secretion, but take easy generation liver fatigue for a long time, and choleresis reduces; Anethol trithione, anethol trithione has choleretic effect, can cause hyperthyroidism and symptom of digestive tract but take for a long time; Phenylpropanol-yichang, phenylpropanol-yichang have function of gallbladder promoting, spasmolytic and oddi's sphincter relaxation effect, but the liver function impairer avoids usefulness.It is long that the medicine of existing treatment acute and chronic cholecystitis all exists the course of treatment, weak curative effect, the big deficiency that waits of side effect, when taking the medicine of existing treatment acute and chronic cholecystitis usually, often to share antibiotic and can obtain the corresponding treatment effect, when gallbladder pain, still needing adds analgesic drug product ability alleviating pain, and analgesic drug product all has side effect usually.
Summary of the invention
Technical problem to be solved by this invention is, a kind of short treating period, evident in efficacy, instant effect are provided, the Chinese medicine preparation of the treatment acute and chronic cholecystitis that analgesic effect is good, have no side effect, and its preparation method is provided.
Solving the technical scheme that its technical problem adopts is: a kind of Chinese medicine preparation for the treatment of acute and chronic cholecystitis, be characterized in that the composition by weight that it comprises is: 20～25 parts of Radix Bupleuri, 15～20 parts of Fructus Aurantii Immaturuss, 20～25 parts of Fructus Gardeniaes, 20～30 parts of Herba Artemisiae Scopariae, 20～30 parts of the Radix Paeoniae Albas, 20～25 parts of Radix Angelicae Sinensis, 15～20 parts of Rhizoma Chuanxiongs, 20～25 parts of Fructus Chaenomeliss, 15～25 parts of Rhizoma Zingiberiss, 25～40 parts of Rhizoma Coptidis, 20～30 parts of Fructus Citri Sarcodactylis, 15～20 parts of Ramulus Cinnamomi, 10～30 parts in Radix Glycyrrhizae.The preferred weight component is: 22～24 parts of Radix Bupleuri, 17～19 parts of Fructus Aurantii Immaturuss, 22～24 parts of Fructus Gardeniaes, 23～28 parts of Herba Artemisiae Scopariae, 23～28 parts of the Radix Paeoniae Albas, 22～24 parts of Radix Angelicae Sinensis, 17～19 parts of Rhizoma Chuanxiongs, 22～24 parts of Fructus Chaenomeliss, 18～23 parts of Rhizoma Zingiberiss, 28～36 parts of Rhizoma Coptidis, 23～28 parts of Fructus Citri Sarcodactylis, 17～19 parts of Ramulus Cinnamomi, 15～25 parts in Radix Glycyrrhizae.
The preparation method of Chinese medicine preparation of the present invention comprises the steps:
1. take by weighing each crude drug by described weight proportion, use the Chinese crude drug dry cleaner and carry out washing;
2. each crude drug after the dry cleaner washing is placed in the hothouse, handle through being lower than 75 ℃ of freeze-day with constant temperature;
3. be ground into 80～120 order fine powders with pulverizer;
4. adding water soluble excipient in described fine powder, is that 60% ethanol is made soft material with the right amount alcohol degree;
5. described soft material is made granule through one-step method fluidization granulation machine, be packaged into every pouch 8g after the drying.
A kind of Chinese medicine preparation for the treatment of acute and chronic cholecystitis of the present invention is to adopt pure raw material of Chinese medicine, crude drug all derives from " Chinese pharmacopoeia, through the science composition of prescription, prescription is unique, reasonable, both considered the merit of liver heat removing function of gallbladder promoting, the capable stagnation pain of dispelling the stagnated QI, consider the detoxifcation antiinflammatory action again emphatically, more consider the synergism of composition of prescription.Radix Bupleuri has tangible hepatic cholagogic effect in the prescription; Compatibility Rhizoma Chuanxiong blood circulation promoting regulates qi, depressed liver-energy dispersing and function of gallbladder promoting; The compatibility Fructus Aurantii Immaturus can reach the merit of the capable stagnation pain of dispelling the stagnated QI; QI stagnated by cold can be joined Ramulus Cinnamomi again, and it plays the effect of clearing away heat and cooling blood, detoxifcation catharsis, function of gallbladder promoting pain relieving; The compatibility Radix Glycyrrhizae still has the Detoxication of adrenal cortex sample except that spasmolysis is arranged; Rhizoma Coptidis has the smooth muscle of inhibition choleretic effect and also has the trivial solution toxic action, experiment and clinical practice confirm still to have antibiotic, antivirus action, and antibiotic general wide, antiinflammatory action is obvious, can also strengthen the phagocytic activity of leukocyte and liver reticuloendothelial system, animal is recovered to some extent because of infection produces dysbolismus.It is the technology prejudice of assisting that the present invention has overcome based on function of gallbladder promoting, detoxifcation antiinflammatory, the Chinese medicine preparation of the treatment acute and chronic cholecystitis that provides is with function of gallbladder promoting and detoxifcation antiinflammatory and deposit, also more pay attention to the detoxifcation antiinflammatory, can accomplish treating both the principal and secondary aspects of a disease, conditioning is combined with treatment, and have that short treating period, evident in efficacy, instant effect, analgesic effect are good, advantage such as have no side effect.
Preparation method of the present invention is scientific and reasonable, and flow process is short, and the effective ingredient of Chinese medicine preparation all keeps, do not have any loss in the manufacturing process.
The specific embodiment
Below in conjunction with embodiment the present invention is further described.
The weight proportion of each crude drug of embodiment 1-5 that preparation the present invention treats the Chinese medicine preparation of acute and chronic cholecystitis sees the following form.Unit of weight: kg
| Routine number | Radix Bupleuri | Fructus Aurantii | Fructus Gardeniae | Herba Artemisiae Scopariae | The Radix Paeoniae Alba | Radix Angelicae Sinensis | Rhizoma Chuanxiong | Fructus Chaenomelis |
| 1 | 20 | 15 | 20 | 20 | 20 | 20 | 15 | 20 |
| 2 | 22 | 17 | 22 | 23 | 23 | 22 | 17 | 22 |
| 3 | 23 | 18 | 23 | 25 | 25 | 23 | 18 | 23 |
| 4 | 24 | 19 | 24 | 28 | 28 | 24 | 19 | 24 |
| 5 | 25 | 20 | 25 | 30 | 30 | 25 | 20 | 25 |
| Routine number | Rhizoma Zingiberis | Rhizoma Coptidis | Fructus Citri Sarcodactylis | Ramulus Cinnamomi | Radix Glycyrrhizae | |||
| 1 | 15 | 25 | 20 | 15 | 10 | |||
| 2 | 18 | 28 | 23 | 17 | 15 | |||
| 3 | 20 | 33 | 25 | 18 | 20 | |||
| 4 | 23 | 36 | 28 | 19 | 25 | |||
| 5 | 25 | 40 | 30 | 20 | 30 |
Each crude drug should meet version " Chinese pharmacopoeia prescription in 2000 among the embodiment.
With embodiment 3 is example, and a kind of preparation method for the treatment of the Chinese medicine preparation of acute and chronic cholecystitis of the present invention comprises the steps that other embodiment is identical with embodiment 3:
1. take by weighing each crude drug by described weight proportion, use the Chinese crude drug dry cleaner to carry out washing, Chinese crude drug dry cleaner washing crude drug can be avoided conventional washing and cause the effective elements of the medicine to run off and the waste and the sewage discharge of water;
2. each crude drug after the dry cleaner washing is placed in the hothouse, handle through being lower than 75 ℃ of freeze-day with constant temperature;
3. be ground into 80～120 order fine powders with pulverizer;
4. adding water soluble excipient in described fine powder, is that the ethanol of 60% (V/V) is made soft material with the right amount alcohol degree, makes granule as long as the soft or hard degree of soft material is suitable for selected comminutor;
5. described soft material is made granule through one-step method fluidization granulation machine, be packaged into every pouch 8g after the drying.
The present invention also can be made into any dosage forms such as powder, capsule except that making the granule by the preparation method of present embodiment.
Described Chinese crude drug dry cleaner is that commercially available XG series Chinese crude drug dry cleaner all can; Pulverizer is that commercially available hammer or Universalpulverizer all can; Comminutor is the commercially available prod; Water soluble excipient and ethanol are commercially available pharmaceutical field adjuvant commonly used.
A kind of Chinese medicine preparation for the treatment of acute and chronic cholecystitis of the present invention during year February in June, 2003 to 2008, to 156 routine acute and chronic cholecystitis patient clinical treatment observations, has been obtained significant curative effect, and its total effective rate is 93.99%.
1. clinical data: amount to case 156 examples, wherein male 74 examples, women 82 examples; The oldest 67 years old, minimum 17 years old, average 42 years old; Acute patient's 66 examples, chronic patients 90; Symptom is looked in clinical sight: heating, right rib flank pain, feel sick, vomiting, abdominal distention; Clinical body is looked into: touch gallbladder enlargement person under upper right abdominal pressure pain, rebound tenderness, tension of abdominal muscle, the right rib and account for 1/3; Lab index: total white blood cells and leaflet increase; Ultrasound diagnosis: can detect out the gallbladder enlargement, cyst wall thickens and gallbladder wall is crude.
2. Therapeutic Method and consumption: the oral pouch content of acute and chronic cholecystitis patient is 8g, and three times on the one, 4～6 weeks were a course of treatment, during treating clinical body look into, lab index check and ultrasound diagnosis.
3. therapeutic evaluation: symptom is looked in clinical sight in 2 weeks, clinical body is looked into and lab index normally is produce effects; Symptom is looked in clinical sight in 6 weeks, clinical body is looked into and lab index normally is effectively.It is fewer that ultrasound diagnosis recovers normal person in a short time, and gallbladder size and the normal person of the crude recovery of gallbladder wall for seeing more.
4. therapeutic effect: in acute patient's 66 examples, produce effects 40 examples, effective 21 examples, invalid 5 examples, effective percentage 92.42%; In chronic patients 90 examples, produce effects 58 examples, effective 28 examples are invalid: 4 examples, effective percentage 95.56%.
Claims (3)
1. Chinese medicine preparation for the treatment of acute and chronic cholecystitis is characterized in that it is made by following medicaments in part by weight: 20～25 parts of Radix Bupleuri, 15～20 parts of Fructus Aurantii Immaturuss, 20～25 parts of Fructus Gardeniaes, 20～30 parts of Herba Artemisiae Scopariae, 20～30 parts of the Radix Paeoniae Albas, 20～25 parts of Radix Angelicae Sinensis, 15～20 parts of Rhizoma Chuanxiongs, 20～25 parts of Fructus Chaenomeliss, 15～25 parts of Rhizoma Zingiberiss, 25～40 parts of Rhizoma Coptidis, 20～30 parts of Fructus Citri Sarcodactylis, 15～20 parts of Ramulus Cinnamomi, 10～30 parts in Radix Glycyrrhizae.
2. a kind of Chinese medicine preparation for the treatment of acute and chronic cholecystitis according to claim 1 is characterized in that it is made by following medicaments in part by weight: 22～24 parts of Radix Bupleuri, 17～19 parts of Fructus Aurantii Immaturuss, 22～24 parts of Fructus Gardeniaes, 23～28 parts of Herba Artemisiae Scopariae, 23～28 parts of the Radix Paeoniae Albas, 22～24 parts of Radix Angelicae Sinensis, 17～19 parts of Rhizoma Chuanxiongs, 22～24 parts of Fructus Chaenomeliss, 18～23 parts of Rhizoma Zingiberiss, 28～36 parts of Rhizoma Coptidis, 23～28 parts of Fructus Citri Sarcodactylis, 17～19 parts of Ramulus Cinnamomi, 15～25 parts in Radix Glycyrrhizae.
3. a kind of preparation method for the treatment of the Chinese medicine preparation of acute and chronic cholecystitis according to claim 1 and 2 is characterized in that comprising the steps:
(1) takes by weighing each crude drug by described weight proportion, use the Chinese crude drug dry cleaner and carry out washing;
(2) each crude drug after the dry cleaner washing is placed in the hothouse, handle through being lower than 75 ℃ of freeze-day with constant temperature;
(3) be ground into 80～120 order fine powders with pulverizer;
(4) adding water soluble excipient in described fine powder, is that 60% ethanol is made soft material with the right amount alcohol degree;
(5) described soft material is made granule through one-step method fluidization granulation machine, be packaged into every pouch 8g after the drying.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2008100507398A CN101279083B (en) | 2008-05-15 | 2008-05-15 | Chinese medicine preparation for curing acute or chronic cholecystitis and method of preparing the same |
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| CN2008100507398A CN101279083B (en) | 2008-05-15 | 2008-05-15 | Chinese medicine preparation for curing acute or chronic cholecystitis and method of preparing the same |
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| CN101279083B true CN101279083B (en) | 2010-07-28 |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102406896B (en) * | 2011-11-28 | 2013-07-10 | 孔繁化 | Medicinal composition for treating chronic cholecystitis |
| CN103768570B (en) * | 2014-02-11 | 2016-01-06 | 杨献美 | A kind of Chinese medicine composition for the treatment of acute cholecystitis and preparation method thereof |
| CN104027751A (en) * | 2014-06-30 | 2014-09-10 | 曹健 | Traditional Chinese medicine preparation for treating chronic cholecystitis |
| CN104721455A (en) * | 2015-04-10 | 2015-06-24 | 王红垒 | Traditional Chinese medicine for treating acute cholecystitis |
| CN104984309A (en) * | 2015-08-06 | 2015-10-21 | 青岛华仁技术孵化器有限公司 | Traditional Chinese medicine composition for treating cholecystitis and preparation method thereof |
| CN106362118A (en) * | 2016-10-25 | 2017-02-01 | 张中彦 | Traditional Chinese medicine preparation for treating acute and chronic cholecystitis |
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| CN1068039A (en) * | 1991-06-21 | 1993-01-20 | 沈亚俊 | Preparation of medicine powder for cholecystitis and cholelithiasis |
| CN1615916A (en) * | 2003-11-12 | 2005-05-18 | 郎伟君 | Medicine for treating cholecystitis |
| CN1772086A (en) * | 2005-10-30 | 2006-05-17 | 李源 | Cholecystitis treating Chinese medicine |
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2008
- 2008-05-15 CN CN2008100507398A patent/CN101279083B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1068039A (en) * | 1991-06-21 | 1993-01-20 | 沈亚俊 | Preparation of medicine powder for cholecystitis and cholelithiasis |
| CN1615916A (en) * | 2003-11-12 | 2005-05-18 | 郎伟君 | Medicine for treating cholecystitis |
| CN1772086A (en) * | 2005-10-30 | 2006-05-17 | 李源 | Cholecystitis treating Chinese medicine |
Non-Patent Citations (3)
| Title |
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| 姜在旸.胆囊炎中医辨证论治七法.中国中医基础医学杂志.2001,7(11),45-47. * |
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| 黄孝全等.急性结石性胆囊炎治疗进展.山东中医杂志.1999,18(1),44-46. * |
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