CN101277746B - 一种用于从液体混合物中分离目标分子的单程方法和装置 - Google Patents

一种用于从液体混合物中分离目标分子的单程方法和装置 Download PDF

Info

Publication number
CN101277746B
CN101277746B CN2006800361836A CN200680036183A CN101277746B CN 101277746 B CN101277746 B CN 101277746B CN 2006800361836 A CN2006800361836 A CN 2006800361836A CN 200680036183 A CN200680036183 A CN 200680036183A CN 101277746 B CN101277746 B CN 101277746B
Authority
CN
China
Prior art keywords
filter cylinder
cylinder module
particle size
stationary
phase particle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2006800361836A
Other languages
English (en)
Chinese (zh)
Other versions
CN101277746A (zh
Inventor
凯利·J·吉本斯
中村雅之
凯南·塞沙德里
安德鲁·W·拉宾斯
拉里·J·卡森
小罗伯特·T·菲茨西蒙斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
3M Innovative Properties Co
Original Assignee
3M Innovative Properties Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3M Innovative Properties Co filed Critical 3M Innovative Properties Co
Publication of CN101277746A publication Critical patent/CN101277746A/zh
Application granted granted Critical
Publication of CN101277746B publication Critical patent/CN101277746B/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1814—Recycling of the fraction to be distributed
    • B01D15/1821—Simulated moving beds
    • B01D15/1828—Simulated moving beds characterised by process features
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1814—Recycling of the fraction to be distributed
    • B01D15/1821—Simulated moving beds
    • B01D15/1842—Simulated moving beds characterised by apparatus features

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Sustainable Development (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
CN2006800361836A 2005-09-30 2006-09-18 一种用于从液体混合物中分离目标分子的单程方法和装置 Expired - Fee Related CN101277746B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/241,524 2005-09-30
US11/241,524 US7413660B2 (en) 2005-09-30 2005-09-30 Single pass method and apparatus for separating a target molecule from a liquid mixture
PCT/US2006/036270 WO2007040967A1 (en) 2005-09-30 2006-09-18 A single pass method and apparatus for separating a target molecule from a liquid mixture

Publications (2)

Publication Number Publication Date
CN101277746A CN101277746A (zh) 2008-10-01
CN101277746B true CN101277746B (zh) 2012-01-18

Family

ID=37686033

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2006800361836A Expired - Fee Related CN101277746B (zh) 2005-09-30 2006-09-18 一种用于从液体混合物中分离目标分子的单程方法和装置

Country Status (6)

Country Link
US (2) US7413660B2 (cg-RX-API-DMAC7.html)
EP (1) EP1945327A1 (cg-RX-API-DMAC7.html)
JP (1) JP2009510435A (cg-RX-API-DMAC7.html)
KR (1) KR20080049791A (cg-RX-API-DMAC7.html)
CN (1) CN101277746B (cg-RX-API-DMAC7.html)
WO (1) WO2007040967A1 (cg-RX-API-DMAC7.html)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1807197A1 (en) * 2004-10-01 2007-07-18 3M Innovative Properties Company Composite filtration article
KR20070065896A (ko) * 2004-10-01 2007-06-25 쓰리엠 이노베이티브 프로퍼티즈 컴파니 액체 혼합물로부터 목표 분자를 분리하기 위한 방법 및장치
US7413660B2 (en) * 2005-09-30 2008-08-19 3M Innovative Properties Company Single pass method and apparatus for separating a target molecule from a liquid mixture
US20090321338A1 (en) * 2008-06-25 2009-12-31 Millipore Corporation Chromatography apparatus
PT104496B (pt) * 2009-04-08 2011-03-14 Univ Do Porto Reactor de membranas adsorptivo de leito móvel simulado, novo processo híbrido de saparação e respectivas utilizações
EP2742982A1 (en) * 2012-12-12 2014-06-18 Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO Highly productive simulated moving bed chromatographic separation
CN103961902B (zh) * 2014-03-27 2015-08-19 浙江大学宁波理工学院 从原料液中分离与浓缩目标组分的模拟移动床色谱分离系统及其方法
JP2017129476A (ja) * 2016-01-21 2017-07-27 シグマアルドリッチジャパン合同会社 固相抽出クロマトグラフィー用貫通型マルチウェルプレート
GB201703116D0 (en) * 2017-02-27 2017-04-12 Ge Healthcare Bioprocess R&D Ab A seperation matrix and a method of seperating antibodies

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599115A (en) * 1983-08-12 1986-07-08 Mitsubishi-Kasei Technoengineers Ltd. Method for controlling simulated moving bed system
US5468847A (en) * 1994-03-10 1995-11-21 Minnesota Mining And Manufacturing Company Method of isolating and purifying a biomacromolecule

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2985589A (en) * 1957-05-22 1961-05-23 Universal Oil Prod Co Continuous sorption process employing fixed bed of sorbent and moving inlets and outlets
US4851573A (en) * 1986-12-18 1989-07-25 Uop Separation of citric acid from fermentation broth with a weakly basic anionic exchange resin adsorbent
US4990259A (en) * 1988-12-16 1991-02-05 The Amalgamated Sugar Company Chromatographic separator sorbent bed preparation
US5770088A (en) * 1992-06-30 1998-06-23 Daicel Chemical Industries, Ltd. Simulated moving bed chromatographic separation process
IT1291978B1 (it) 1997-05-22 1999-01-25 Hydro Air Research S R L Procedimento di purificazione di percolato di discarica mediante ultrafiltrazione ed osmosi inversa
JPH1190106A (ja) * 1997-09-26 1999-04-06 Daicel Chem Ind Ltd 擬似移動床式クロマト分離装置
US6280623B1 (en) * 1999-03-23 2001-08-28 Hsien-Chih Ma Differential and continuous separation apparatus with controlled parameters for solids and liquids
FR2794663B1 (fr) * 1999-06-09 2001-07-13 Inst Francais Du Petrole Systeme d'injection d'un fluide devie dans un procede de separation en lit mobile simule
ES2379540T3 (es) * 2000-01-27 2012-04-27 Amalgamated Research, Inc. Aparato de tratamiento de fluido en lecho poco profundo
KR100567942B1 (ko) * 2000-03-10 2006-04-07 닛폰렌스이가부시키가이샤 크로마토그래피 분리공정의 제어방법
JP4879392B2 (ja) * 2000-11-09 2012-02-22 日本錬水株式会社 クロマト分離方法
JP2002153702A (ja) 2000-11-21 2002-05-28 Japan Organo Co Ltd トコトリエノ−ルのクロマト分取法
JP4822382B2 (ja) * 2001-08-23 2011-11-24 月島機械株式会社 砂糖の精製に用いる糖液の脱塩処理装置
US7141172B2 (en) * 2001-09-27 2006-11-28 Purdue Research Foundation Versatile simulated moving bed systems
US6683220B2 (en) * 2001-10-31 2004-01-27 Pfizer, Inc. Process for the preparation of optically pure or enriched racemic tetralone
SI1545574T1 (sl) 2002-09-13 2014-10-30 Biogen Idec Inc. Postopek za čiščenje polipeptidov s simulirano "moving bed" kromatografijo
KR20070065896A (ko) * 2004-10-01 2007-06-25 쓰리엠 이노베이티브 프로퍼티즈 컴파니 액체 혼합물로부터 목표 분자를 분리하기 위한 방법 및장치
US7413660B2 (en) * 2005-09-30 2008-08-19 3M Innovative Properties Company Single pass method and apparatus for separating a target molecule from a liquid mixture

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599115A (en) * 1983-08-12 1986-07-08 Mitsubishi-Kasei Technoengineers Ltd. Method for controlling simulated moving bed system
US4599115B1 (cg-RX-API-DMAC7.html) * 1983-08-12 1988-06-28
US5468847A (en) * 1994-03-10 1995-11-21 Minnesota Mining And Manufacturing Company Method of isolating and purifying a biomacromolecule

Also Published As

Publication number Publication date
EP1945327A1 (en) 2008-07-23
WO2007040967A1 (en) 2007-04-12
KR20080049791A (ko) 2008-06-04
JP2009510435A (ja) 2009-03-12
US8956535B2 (en) 2015-02-17
US20070075022A1 (en) 2007-04-05
US7413660B2 (en) 2008-08-19
US20080264849A1 (en) 2008-10-30
CN101277746A (zh) 2008-10-01

Similar Documents

Publication Publication Date Title
US6214221B1 (en) Method and apparatus for purification of biological substances
US8956535B2 (en) Single pass method and apparatus for separating a target molecule from a liquid mixture
EP0749440B1 (en) Method of isolating and purifying a biomacromolecule
AU756832B2 (en) Purification of biological substances
JP4139333B2 (ja) クロマトグラフィー用の方法及び組成物
CN108404453A (zh) 层析介质和方法
US20080128358A1 (en) Process and apparatus for adsorptive separation of substances
US7488422B2 (en) Method and apparatus for separating a target molecule from a liquid mixture
CN121314243A (zh) 层析系统
KR102828839B1 (ko) 생체분자의 분리 방법
EP4013528B1 (en) Process for purifying target substances
Li et al. Expanded bed adsorption/desorption of proteins with Streamline Direct CST I adsorbent
CN109078505A (zh) 一种含有吸附介质的复合层析过滤膜及其制备方法和应用
WO1991010492A1 (en) Apparatus and method for affinity separation
Yang et al. Protein subunit vaccine purification
WO2001037959A1 (de) Verfahren zur separation von zellen und biomolekülen mittels gegenstromchromatographie

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20120118

Termination date: 20150918

EXPY Termination of patent right or utility model